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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRMP1 Gene

protein-coding   GIFtS: 64
GCID: GC04M005815

Collapsin Response Mediator Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Collapsin Response Mediator Protein 11 2 3     DRP12 5
DPYSL12 3 5     Dihydropyrimidinase Related Protein-12
Unc-33-Like Phosphoprotein 32 3     Dihydropyrimidinase-Like 12
CRMP-12 3     Dihydropyrimidinase-Related Protein 12
DRP-12 3     ULIP33
ULIP-32 3     

External Ids:    HGNC: 23651   Entrez Gene: 14002   Ensembl: ENSG000000728327   OMIM: 6024625   UniProtKB: Q141943   

Export aliases for CRMP1 gene to outside databases

Previous GC identifers: GC04M005704 GC04P005871 GC04M005887 GC04M005940


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRMP1 Gene:
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system.
The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in
semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRMP1 Gene: 
CRMP1 (collapsin response mediator protein 1) is a protein-coding gene. Diseases associated with CRMP1 include ellis-van creveld syndrome, and lung adenocarcinoma, and among its related super-pathways are Axon guidance and Sema4D in semaphorin signaling. GO annotations related to this gene include protein binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
role in axon guidance, invasive growth and cell migration

Gene Wiki entry for CRMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRMP1 gene promoter:
         NRSF form 1   MyoD   NRSF form 2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.2   HGNC cytogenetic band: 4p16.1

CRMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M005815:  view genomic region     (about GC identifiers)

Start:
5,749,811 bp from pter      End:
5,894,785 bp from pter
Size:
144,975 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 1  
Size: 572 amino acids; 62184 Da
Subunit: Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By
similarity)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
Secondary accessions: A0EJG6 Q13024 Q4W5F1 Q96TC8
Alternative splicing: 2 isoforms:  Q14194-1   Q14194-2   

Explore the universe of human proteins at neXtProt for CRMP1: NX_Q14194

Explore proteomics data for CRMP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14194

  • CRMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRMP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001014809.1  NP_001304.1  

    ENSEMBL proteins: 
     ENSP00000321606   ENSP00000380987   ENSP00000425742  
    Reactome Protein details: Q14194
    Human Recombinant Protein Products for CRMP1: 
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    Novus Biologicals CRMP1 Proteins
    Novus Biologicals CRMP1 Lysate
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CRMP1
    Cloud-Clone Corp. Proteins for CRMP1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--

    CRMP1 for ontologies           About GeneDecksing



    CRMP1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CRMP1 

    Assay Products for CRMP1: 
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    Cloud-Clone Corp. ELISAs for CRMP1 
    Cloud-Clone Corp. CLIAs for CRMP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR011059 Metal-dep_hydrolase_composite
     IPR006680 Amidohydro_1

    Graphical View of Domain Structure for InterPro Entry Q14194

    ProtoNet protein and cluster: Q14194

    2 Blocks protein domains:
    IPB005847 Dihydroorotase region
    IPB011550 Amidohydrolase-like


    UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    CRMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPYL1_HUMAN, Q14194
    Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
    role in axon guidance, invasive growth and cell migration

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--
         
    CRMP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRMP1:
     Increased cell number in G1, s 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crmp1):
     behavior/neurological  cellular  nervous system 

    CRMP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crmp1tm1.1Swl for CRMP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRMP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRMP1 
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    miRNA
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    hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidCRMP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRMP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Sema4D in semaphorin signaling
    Semaphorin interactions0.41
    3SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    CRMPs in Sema3A signaling0.36
    4Semaphorin Signaling
    Semaphorin Signaling
    5Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRMP1
        Guidance Cues and Growth Cone Motility
    Semaphorin Signaling


    4        Reactome Pathways for CRMP1
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance



    CRMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for CRMP1 (Q141941, 2, 3 ENSP000003216064) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151691, 2, 3EBI-473101,EBI-710484 MINT-64312 I2D: score=4 
    ENSG00000172850Q9Y3332, 3MINT-65810 I2D: score=4 
    ENSG00000224979Q9Y3332, 3MINT-65810 I2D: score=4 
    ENSG00000225998Q9Y3332, 3MINT-65810 I2D: score=4 
    ENSG00000231502Q9Y3332, 3MINT-65810 I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS8973361
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007399nervous system development TAS8973361
    GO:0007411axon guidance TAS--
    GO:0048666neuron development ----

    CRMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRMP1 (DPYL1)

    Search CenterWatch for drugs/clinical trials and news about CRMP1 / DPYL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRMP1 gene (2 alternative transcripts): 
    NM_001014809.1  NM_001313.3  

    Unigene Cluster for CRMP1:

    Collapsin response mediator protein 1
    Hs.135270  [show with all ESTs]
    Unigene Representative Sequence: NM_001014809
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506216 ENST00000324989(uc003gis.3) ENST00000397890(uc003giq.3)
    ENST00000513911 ENST00000511535 ENST00000512574(uc003gir.3)
    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CRMP1 (see all 26):
    hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidCRMP1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRMP1
    Sirion Biotech Customized lentivirus for stable overexpression of CRMP1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRMP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRMP1

    Additional mRNA sequence: 

    AK091696.1 AK094725.1 AK122754.1 AK127754.1 AK309379.1 BC000252.1 BC007613.1 BC007898.2 
    BT006806.1 D78012.1 DQ206871.1 U17278.1 

    20 DOTS entries:

    DT.100762743  DT.100821208  DT.101983853  DT.100821182  DT.219724  DT.95087464  DT.100802877  DT.121270089 
    DT.100821181  DT.100821207  DT.121270099  DT.100821189  DT.100821214  DT.95087523  DT.100652789  DT.121270015 
    DT.121270062  DT.92448235  DT.102835332  DT.219725 

    24/379 AceView cDNA sequences (see all 379):

    AA449627 BX441447 AW162899 AA333470 AK094725 Z42153 BM697311 BM893586 
    BC007613 AI357768 BM698495 AW583553 BM984316 AA873063 BE019357 BU687205 
    CR622220 T32217 BG055997 T31787 AI268591 AA948277 NM_001313 AA450245 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:              -     -     -                             -                                                           -           -                           
    SP2:                                                        -                                                           -           -                           
    SP3:                                      -     -     -     -                                                                                                   
    SP4:                                      -                 -                                                                                                   
    SP5:              -     -     -                                                                                                                                 


    ECgene alternative splicing isoforms for CRMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRMP1 expression in normal human tissues (normalized intensities)      CRMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRMP1 Expression
    About this image


    CRMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Endothelial Cells Blood Brain Barrier
             Human Cerebellar Astrocytes   
             ganglion/cranial/facial VII   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             ESI-049   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             Human Perineurial Cells (HPC)   
             autonomic/sympathetic/ganglion   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human Lens Epithelial Cells (HLEpiC)   

    See CRMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRMP1

    SOURCE GeneReport for Unigene cluster: Hs.135270

    UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Tissue specificity: Brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CRMP1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crmp11 , 5 collapsin response mediator protein 11, 5 89.26(n)1
    96.5(a)1
      5 (19.96 cM)5
    129331  NM_001136058.11  NP_001129530.11 
     372420805 
    chicken
    (Gallus gallus)
    Aves CRMP11 collapsin response mediator protein 1 81.75(n)
    93.74(a)
      395156  NM_204495.1  NP_989826.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRMP16
    --
    --
    85(a)
    21(a)
    1 ↔ 1
    possible ortholog
    5(80502695-80553498)
    3(35153312-35184148)
    zebrafish
    (Danio rerio)
    Actinopterygii crmp11 collapsin response mediator protein 1 72.87(n)
    79.61(a)
      553756  NM_001020725.1  NP_001018561.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CRMP3 dihydropyrimidinase 45(a)   83B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea dhp-23 Ulip like protein 48(a)
    (best of 3)
      IV(9978361-9980884)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAL16
    Allantoinase, converts allantoin to allantoate in ...
    20(a)
    1 → many
    IX(406260-407642)


    ENSEMBL Gene Tree for CRMP1 (if available)
    TreeFam Gene Tree for CRMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRMP1 gene
    DPYSL32  DPYSL42  DPYSL52  DPYS2  DPYSL22  
    5 SIMAP similar genes for CRMP1 using alignment to 4 protein entries:     DPYL1_HUMAN (see all proteins):
    DPYSL2    DPYSL3    DPYSL4    DPYSL5    DPYS

    CRMP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1992 SNPs in CRMP1 are shown (see all 1992)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106081221,2
    C--5812050(+) AAAAA-/A/A   
       A
    /AAA
    GAGAT
    2 -- int11NA 2
    rs1833140501,2
    --5822022(+) ATCATA/CACCAT 2 -- ds50010--------
    rs1481650341,2
    C--5822074(+) TTACT-/AACAACAG 2 -- ds50010--------
    rs38365521,2
    C--5822075(+) TAACA-/ACAGCTAA 2 -- ds50010--------
    rs1465932091,2
    C--5822119(+) TTATCC/TGTCCT 2 -- ds50010--------
    rs1892167121,2
    --5822169(+) GTGAAC/GTTTAG 2 -- ds50010--------
    rs1151455161,2
    C--5822257(+) AATCAA/GTGCAA 2 -- ds50010--------
    rs1498499811,2
    --5822274(+) AGCCTA/GTTTTG 2 -- ds50010--------
    rs1145703481,2
    F--5822443(+) CACGCG/AGGGGG 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1488186311,2
    C--5822460(+) AAGCAG/TTCGTA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRMP1 (5749811 - 5894785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for CRMP1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678074CNV Deletion23128226
    esv2726979CNV Deletion23290073
    esv2726978CNV Deletion23290073
    esv2279377CNV Deletion18987734
    nsv293630CNV Loss16902084
    nsv829845CNV Loss17160897
    esv7115CNV Loss19470904
    nsv822449CNV Gain20364138
    nsv829844CNV Gain17160897
    esv29375CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602462    OMIM disorders: --

    10 diseases for CRMP1:    About MalaCards
    ellis-van creveld syndrome    lung adenocarcinoma    macular degeneration    down syndrome
    ataxia    adenocarcinoma    tuberculosis    lung cancer
    leukemia    neuronitis


    CRMP1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CRMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 33.9 3 11562390 (3)
    metastasis 16.9 4 11562390 (2), 12650609 (1), 14996858 (1)
    cancer 7.58 4 12650609 (2), 18524846 (1), 11562390 (1)

    Genetic Association Database (GAD): CRMP1
    Human Genome Epidemiology (HuGE) Navigator: CRMP1 (2 documents)

    Export disorders for CRMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRMP1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with CRMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (1996)
    2. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PubMed id 11562390)1, 2, 9 Shih J.-Y.... Yang P.-C. (2001)
    3. Genomic organization and localization of the human CRMP-1 gene. (PubMed id 10048489)1, 2, 9 Torres R. and Polymeropoulos M.H. (1998)
    4. Long form collapsin response mediator protein-1 (LCRM P-1) expression is associated with clinical outcome and lymph node metastasis i n non-small cell lung cancer patients. (PubMed id 19362386)1, 2, 9 Pan S.H....Yang P.C. (2010)
    5. Association between genes on chromosome 4p16 and non- syndromic oral clefts in four populations. (PubMed id 20087401)1, 4 Ingersoll R.G....Beaty T.H. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha. (PubMed id 18524846)1, 9 Wu C.C....Yang P.C. (2008)
    9. Loss of collapsin response mediator Protein1, as dete cted by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EG FRvIII. (PubMed id 19903856)1, 9 Mukherjee J....Guha A. (2009)
    10. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PubMed id 15492864)1, 9 Sivakumaran T.A. and Lesperance M.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1400 HGNC: 2365 AceView: CRMP1 Ensembl:ENSG00000072832 euGenes: HUgn1400
    ECgene: CRMP1 H-InvDB: CRMP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRMP1 gene:
    Search GeneIP for patents involving CRMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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