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CRMP1 Gene

protein-coding   GIFtS: 64
GCID: GC04M005815

Collapsin Response Mediator Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collapsin Response Mediator Protein 11 2 3     ULIP-32 3
DPYSL12 3 5     DRP12 5
Unc-33-Like Phosphoprotein 32 3     Dihydropyrimidinase-Like 12
CRMP-12 3     Dihydropyrimidinase-Related Protein 12
DRP-12 3     ULIP33

External Ids:    HGNC: 23651   Entrez Gene: 14002   Ensembl: ENSG000000728327   OMIM: 6024625   UniProtKB: Q141943   

Export aliases for CRMP1 gene to outside databases

Previous GC identifers: GC04M005704 GC04P005871 GC04M005887 GC04M005940


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRMP1 Gene:
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system.
The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in
semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRMP1 Gene:
CRMP1 (collapsin response mediator protein 1) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
role in axon guidance, invasive growth and cell migration. May participate in cytokinesis

Gene Wiki entry for CRMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRMP1 gene promoter:
         NRSF form 1   MyoD   NRSF form 2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRMP1 promoter sequence
   Search Chromatin IP Primers for CRMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.2   HGNC cytogenetic band: 4p16.1

CRMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M005815:  view genomic region     (about GC identifiers)

Start:
5,749,811 bp from pter      End:
5,894,785 bp from pter
Size:
144,975 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 1  
Size: 572 amino acids; 62184 Da
Subunit: Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By
similarity)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
1 PDB 3D structure from and Proteopedia for CRMP1:
4B3Z (3D)    
Secondary accessions: A0EJG6 Q13024 Q4W5F1 Q96TC8
Alternative splicing: 2 isoforms:  Q14194-1   Q14194-2   

Explore the universe of human proteins at neXtProt for CRMP1: NX_Q14194

Explore proteomics data for CRMP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001014809.1  NP_001275590.1  NP_001275591.1  NP_001304.1  

    ENSEMBL proteins: 
     ENSP00000321606   ENSP00000380987   ENSP00000425742  
    Reactome Protein details: Q14194

    CRMP1 Human Recombinant Protein Products:

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    Novus Biologicals CRMP1 Proteins
    Novus Biologicals CRMP1 Lysate
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    Cloud-Clone Corp. Proteins for CRMP1

     
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    CRMP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for CRMP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR011059 Metal-dep_hydrolase_composite
     IPR006680 Amidohydro_1

    Graphical View of Domain Structure for InterPro Entry Q14194

    ProtoNet protein and cluster: Q14194

    2 Blocks protein domains:
    IPB005847 Dihydroorotase region
    IPB011550 Amidohydrolase-like


    UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    Find genes that share domains with CRMP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPYL1_HUMAN, Q14194
    Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
    role in axon guidance, invasive growth and cell migration. May participate in cytokinesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--
         
    Find genes that share ontologies with CRMP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CRMP1:
     Increased cell number in G1, s 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crmp1):
     behavior/neurological  cellular  nervous system 

    Find genes that share phenotypes with CRMP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crmp1tm1.1Swl for CRMP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRMP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRMP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRMP1

    miRNA
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    Block miRNA regulation of human, mouse, rat CRMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRMP1 (see all 26):
    hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidCRMP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CRMP1
    Predesigned siRNA for gene silencing in human, mouse, rat CRMP1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CRMP1 (NM_001313)
    Sino Biological Human cDNA Clone for CRMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRMP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPYL1_HUMAN, Q14194: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--

    Find genes that share ontologies with CRMP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRMP1 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Semaphorin interactions
    Semaphorin interactions0.43
    CRMPs in Sema3A signaling0.00
    3Semaphorin Signaling
    Semaphorin Signaling
    4Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility


    Find genes that share SuperPaths with CRMP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRMP1
        Guidance Cues and Growth Cone Motility
    Semaphorin Signaling


    1 Reactome Pathway for CRMP1
        CRMPs in Sema3A signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRMP1
    Interactions:

        GeneGlobe Interaction Network for CRMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRMP1 (Q141941, 2, 3 ENSP000003216064) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151691, 2, 3EBI-473101,EBI-710484 MINT-64312 I2D: score=4 
    ENSG00000172850Q9Y3332, 3MINT-65810 I2D: score=4 
    ENSG00000224979Q9Y3332, 3MINT-65810 I2D: score=4 
    ENSG00000225998Q9Y3332, 3MINT-65810 I2D: score=4 
    ENSG00000231502Q9Y3332, 3MINT-65810 I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS8973361
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007399nervous system development TAS8973361
    GO:0007411axon guidance TAS--
    GO:0048666neuron development ----

    Find genes that share ontologies with CRMP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRMP1 (DPYL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRMP1 gene (4 alternative transcripts): 
    NM_001014809.2  NM_001288661.1  NM_001288662.1  NM_001313.4  

    Unigene Cluster for CRMP1:

    Collapsin response mediator protein 1
    Hs.135270  [show with all ESTs]
    Unigene Representative Sequence: NM_001014809
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506216 ENST00000324989(uc003gis.3) ENST00000397890(uc003giq.3)
    ENST00000513911 ENST00000511535 ENST00000512574(uc003gir.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CRMP1 (see all 26):
    hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidCRMP1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRMP1
      QuantiTect SYBR Green Assays in human, mouse, rat CRMP1
      QuantiFast Probe-based Assays in human, mouse, rat CRMP1

    Additional mRNA sequence: 

    AK091696.1 AK094725.1 AK122754.1 AK127754.1 AK309379.1 BC000252.1 BC007613.1 BC007898.2 
    BT006806.1 D78012.1 DQ206871.1 U17278.1 

    20 DOTS entries:

    DT.100762743  DT.100821208  DT.101983853  DT.100821182  DT.219724  DT.95087464  DT.100802877  DT.121270089 
    DT.100821181  DT.100821207  DT.121270099  DT.100821189  DT.100821214  DT.95087523  DT.100652789  DT.121270015 
    DT.121270062  DT.92448235  DT.102835332  DT.219725 

    Selected AceView cDNA sequences (see all 379):

    AW732221 AW162899 AA333470 AK094725 Z42153 BM697311 BM893586 BC007613 
    AI357768 BM698495 AW583553 BM984316 AA873063 BE019357 BU687205 CR622220 
    AI299048 T32217 BG055997 T31787 AI268591 AA948277 NM_001313 AA450245 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:              -     -     -                             -                                                           -           -                           
    SP2:                                                        -                                                           -           -                           
    SP3:                                      -     -     -     -                                                                                                   
    SP4:                                      -                 -                                                                                                   
    SP5:              -     -     -                                                                                                                                 


    ECgene alternative splicing isoforms for CRMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRMP1 Expression
    About this image


    CRMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
    CRMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRMP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135270

    UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Tissue specificity: Brain

        Custom PCR Arrays for CRMP1
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    QuantiFast Probe-based Assays in human, mouse, rat CRMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRMP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crmp11 , 5 collapsin response mediator protein 11, 5 89.26(n)1
    96.5(a)1
      5 (19.96 cM)5
    129331  NM_001136058.21  NP_001129530.11 
     372420805 
    chicken
    (Gallus gallus)
    Aves CRMP11 collapsin response mediator protein 1 81.75(n)
    93.74(a)
      395156  NM_204495.1  NP_989826.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRMP16
    collapsin response mediator protein 1
    85(a)
    1 ↔ 1
    5(80502695-80553498)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crmp11 collapsin response mediator protein 1 75.11(n)
    84.83(a)
      779767  NM_001078846.1  NP_001072314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crmp11 collapsin response mediator protein 1 72.87(n)
    79.61(a)
      553756  NM_001020725.1  NP_001018561.1 


    ENSEMBL Gene Tree for CRMP1 (if available)
    TreeFam Gene Tree for CRMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRMP1 gene
    DPYSL32  DPYSL42  DPYSL52  DPYS2  DPYSL22  
    5 SIMAP similar genes for CRMP1 using alignment to 4 protein entries:     DPYL1_HUMAN (see all proteins):
    DPYSL2    DPYSL3    DPYSL4    DPYSL5    DPYS

    Find genes that share paralogs with CRMP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRMP1 (see all 1992)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106081221,2
    C--5812050(+) AAAAA-/A/A   
       A
    /AAA
    GAGAT
    2 -- int11NA 2
    rs1833140501,2
    --5822022(+) ATCATA/CACCAT 2 -- ds50010--------
    rs1481650341,2
    C--5822074(+) TTACT-/AACAACAG 2 -- ds50010--------
    rs38365521,2
    C--5822075(+) TAACA-/ACAGCTAA 2 -- ds50010--------
    rs1465932091,2
    C--5822119(+) TTATCC/TGTCCT 2 -- ds50010--------
    rs1892167121,2
    --5822169(+) GTGAAC/GTTTAG 2 -- ds50010--------
    rs1151455161,2
    C--5822257(+) AATCAA/GTGCAA 2 -- ds50010--------
    rs1498499811,2
    --5822274(+) AGCCTA/GTTTTG 2 -- ds50010--------
    rs1145703481,2
    F--5822443(+) CACGCG/AGGGGG 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1488186311,2
    C--5822460(+) AAGCAG/TTCGTA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRMP1 (5749811 - 5894785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CRMP1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678074CNV Deletion23128226
    esv2726979CNV Deletion23290073
    esv2726978CNV Deletion23290073
    esv2279377CNV Deletion18987734
    nsv293630CNV Loss16902084
    nsv829845CNV Loss17160897
    esv7115CNV Loss19470904
    nsv822449CNV Gain20364138
    nsv829844CNV Gain17160897
    esv29375CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): CRMP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602462    OMIM disorders: --


    Find genes that share disorders with CRMP1           About GenesLikeMe

    3 Novoseek inferred disease relationships for CRMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 33.9 3 11562390 (3)
    metastasis 16.9 4 11562390 (2), 12650609 (1), 14996858 (1)
    cancer 7.58 4 12650609 (2), 18524846 (1), 11562390 (1)

    Genetic Association Database (GAD): CRMP1
    Human Genome Epidemiology (HuGE) Navigator: CRMP1 (2 documents)

    Export disorders for CRMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRMP1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with CRMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (Gene 1996)
    2. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PubMed id 11562390)1, 2, 9 Shih J.-Y.... Yang P.-C. (J. Natl. Cancer Inst. 2001)
    3. Genomic organization and localization of the human CRMP-1 gene. (PubMed id 10048489)1, 2, 9 Torres R. and Polymeropoulos M.H. (DNA Res. 1998)
    4. Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non- small cell lung cancer patients. (PubMed id 19362386)1, 2, 9 Pan S.-H.... Yang P.-C. (Lung Cancer 2010)
    5. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PubMed id 20087401)1, 4 Ingersoll R.G....Beaty T.H. (Eur. J. Hum. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha. (PubMed id 18524846)1, 9 Wu C.C....Yang P.C. (Mol. Cancer Ther. 2008)
    9. Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIII. (PubMed id 19903856)1, 9 Mukherjee J....Guha A. (Cancer Res. 2009)
    10. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PubMed id 15492864)1, 9 Sivakumaran T.A. and Lesperance M.M. (Int. J. Mol. Med. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1400 HGNC: 2365 AceView: CRMP1 Ensembl:ENSG00000072832 euGenes: HUgn1400
    ECgene: CRMP1 H-InvDB: CRMP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRMP1 gene:
    Search GeneIP for patents involving CRMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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