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Aliases for CRMP1 Gene

Aliases for CRMP1 Gene

  • Collapsin Response Mediator Protein 1 2 3 4
  • DPYSL1 3 4 6
  • Unc-33-Like Phosphoprotein 3 3 4
  • CRMP-1 3 4
  • ULIP-3 3 4
  • DRP-1 3 4
  • DRP1 3 6
  • Dihydropyrimidinase-Related Protein 1 3
  • Dihydropyrimidinase-Like 1 3
  • ULIP3 4

External Ids for CRMP1 Gene

Previous GeneCards Identifiers for CRMP1 Gene

  • GC04M005704
  • GC04P005871
  • GC04M005887
  • GC04M005940

Summaries for CRMP1 Gene

Entrez Gene Summary for CRMP1 Gene

  • This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRMP1 Gene

CRMP1 (Collapsin Response Mediator Protein 1) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot for CRMP1 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.

Gene Wiki entry for CRMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRMP1 Gene

Genomics for CRMP1 Gene

Regulatory Elements for CRMP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRMP1 Gene

Start:
5,748,084 bp from pter
End:
5,893,083 bp from pter
Size:
145,000 bases
Orientation:
Minus strand

Genomic View for CRMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRMP1 Gene

Proteins for CRMP1 Gene

  • Protein details for CRMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14194-DPYL1_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 1
    Protein Accession:
    Q14194
    Secondary Accessions:
    • A0EJG6
    • Q13024
    • Q4W5F1
    • Q96TC8

    Protein attributes for CRMP1 Gene

    Size:
    572 amino acids
    Molecular mass:
    62184 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CRMP1 Gene

    Alternative splice isoforms for CRMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRMP1 Gene

Proteomics data for CRMP1 Gene at MOPED

Post-translational modifications for CRMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRMP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRMP1 Gene

Domains for CRMP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14194

UniProtKB/Swiss-Prot:

DPYL1_HUMAN :
  • Q14194
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with CRMP1: view

No data available for Gene Families for CRMP1 Gene

Function for CRMP1 Gene

Molecular function for CRMP1 Gene

UniProtKB/Swiss-Prot Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.

Gene Ontology (GO) - Molecular Function for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383276
GO:0016787 hydrolase activity --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides --
genes like me logo Genes that share ontologies with CRMP1: view

Phenotypes for CRMP1 Gene

genes like me logo Genes that share phenotypes with CRMP1: view

Animal Models for CRMP1 Gene

MGI Knock Outs for CRMP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRMP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CRMP1 Gene

Localization for CRMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRMP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRMP1 Gene COMPARTMENTS Subcellular localization image for CRMP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with CRMP1: view

Pathways for CRMP1 Gene

genes like me logo Genes that share pathways with CRMP1: view

Pathways by source for CRMP1 Gene

Gene Ontology (GO) - Biological Process for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 8973361
GO:0006208 pyrimidine nucleobase catabolic process --
GO:0007399 nervous system development TAS 8973361
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with CRMP1: view

Transcripts for CRMP1 Gene

Unigene Clusters for CRMP1 Gene

Collapsin response mediator protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRMP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CRMP1 Gene

GeneLoc Exon Structure for
CRMP1
ECgene alternative splicing isoforms for
CRMP1

Expression for CRMP1 Gene

mRNA expression in normal human tissues for CRMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRMP1 Gene

SOURCE GeneReport for Unigene cluster for CRMP1 Gene Hs.135270

mRNA Expression by UniProt/SwissProt for CRMP1 Gene

Q14194-DPYL1_HUMAN
Tissue specificity: Brain
genes like me logo Genes that share expressions with CRMP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CRMP1 Gene

Orthologs for CRMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRMP1 35
  • 99.51 (n)
  • 99.42 (a)
CRMP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRMP1 35
  • 91.59 (n)
  • 97.5 (a)
CRMP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRMP1 35
  • 91.16 (n)
  • 97.23 (a)
CRMP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crmp1 35
  • 89.26 (n)
  • 96.5 (a)
Crmp1 16
Crmp1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRMP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRMP1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crmp1 35
  • 88.13 (n)
  • 96.78 (a)
chicken
(Gallus gallus)
Aves CRMP1 35
  • 81.75 (n)
  • 93.74 (a)
CRMP1B 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRMP1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crmp1 35
  • 75.11 (n)
  • 84.83 (a)
zebrafish
(Danio rerio)
Actinopterygii crmp1 35
  • 72.87 (n)
  • 79.61 (a)
crmp1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-33 37
  • 32 (a)
dhp-2 37
  • 48 (a)
dhp-1 37
  • 46 (a)
Species with no ortholog for CRMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRMP1 Gene

ENSEMBL:
Gene Tree for CRMP1 (if available)
TreeFam:
Gene Tree for CRMP1 (if available)

Paralogs for CRMP1 Gene

Paralogs for CRMP1 Gene

Selected SIMAP similar genes for CRMP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRMP1: view

Variants for CRMP1 Gene

Sequence variations from dbSNP and Humsavar for CRMP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12331 -- 5,836,786(-) ATGAC(A/C/G)GTCGT synonymous-codon, reference
rs984576 -- 5,850,411(+) TTTGA(A/G)TGTCT intron-variant
rs984577 -- 5,850,632(+) TTCAA(C/G)TGCCT intron-variant
rs1383181 -- 5,838,483(-) cttCC(G/T)ACCAA intron-variant
rs1383182 -- 5,838,344(-) GTCCC(C/T)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRMP1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv829844 CNV Gain 17160897
esv7115 CNV Loss 19470904
esv2678074 CNV Deletion 23128226
esv2726978 CNV Deletion 23290073
esv2726979 CNV Deletion 23290073
esv2279377 CNV Deletion 18987734
nsv293630 CNV Loss 16902084
nsv829845 CNV Loss 17160897
nsv822449 CNV Gain 20364138
esv29375 CNV Gain+Loss 19812545

Relevant External Links for CRMP1 Gene

HapMap Linkage Disequilibrium report
CRMP1
Human Gene Mutation Database (HGMD)
CRMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRMP1 Gene

Disorders for CRMP1 Gene

(3) Novoseek inferred disease relationships for CRMP1 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 33.9 3
metastasis 16.9 4
cancer 7.58 4

Relevant External Links for CRMP1

Genetic Association Database (GAD)
CRMP1
Human Genome Epidemiology (HuGE) Navigator
CRMP1
genes like me logo Genes that share disorders with CRMP1: view

No data available for UniProtKB/Swiss-Prot for CRMP1 Gene

Publications for CRMP1 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N. … Nonaka M. (Gene 1996) 2 3 4 23
  2. Genomic organization and localization of the human CRMP-1 gene. (PMID: 10048489) Torres R. … Polymeropoulos M.H. (DNA Res. 1998) 3 4 23
  3. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PMID: 11562390) Shih J.-Y. … Yang P.-C. (J. Natl. Cancer Inst. 2001) 3 4 23
  4. Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non- small cell lung cancer patients. (PMID: 19362386) Pan S.-H. … Yang P.-C. (Lung Cancer 2010) 3 4 23
  5. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PMID: 15492864) Sivakumaran T.A. … Lesperance M.M. (Int. J. Mol. Med. 2004) 3 23

Products for CRMP1 Gene

Sources for CRMP1 Gene

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