Aliases for CRMP1 Gene
External Ids for CRMP1 Gene
Previous GeneCards Identifiers for CRMP1 Gene
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRMP1 Gene
CRMP1 (Collapsin Response Mediator Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL5.
UniProtKB/Swiss-Prot for CRMP1 Gene
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.