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Aliases for CDC16 Gene

Aliases for CDC16 Gene

  • Cell Division Cycle 16 2 3 5
  • Anaphase-Promoting Complex, Subunit 6 2 3
  • Cyclosome Subunit 6 3 4
  • CDC16Hs 3 4
  • ANAPC6 3 4
  • APC6 3 4
  • CDC16 (Cell Division Cycle 16, S. Cerevisiae, Homolog) 2
  • CDC16 Cell Division Cycle 16 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 16 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 16 Homolog 3
  • Anaphase-Promoting Complex Subunit 6 4
  • Cell Division Cycle 16 Homolog 3
  • CDC16 Homolog 4
  • CUT9 3

External Ids for CDC16 Gene

Previous GeneCards Identifiers for CDC16 Gene

  • GC13P113361
  • GC13P111188
  • GC13P114022
  • GC13P112918
  • GC13P114018
  • GC13P115000
  • GC13P095262

Summaries for CDC16 Gene

Entrez Gene Summary for CDC16 Gene

  • The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

GeneCards Summary for CDC16 Gene

CDC16 (Cell Division Cycle 16) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and DNA Damage.

UniProtKB/Swiss-Prot for CDC16 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC16 Gene

Additional gene information for CDC16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC16 Gene

Genomics for CDC16 Gene

Regulatory Elements for CDC16 Gene

Enhancers for CDC16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H114126 2 FANTOM5 Ensembl ENCODE dbSUPER 71.5 -105.1 -105137 7 HDGF ARNT SIN3A ZNF2 FOS REST SMARCB1 ZNF592 SMARCA4 GLIS1 CDC16 PCID2 GAS6 CHAMP1 RASA3 GAS6-AS1 LDHBP1 LINC00454 UPF3A LINC00565
GH13H114279 1.7 FANTOM5 ENCODE dbSUPER 75.1 +46.4 46369 4.3 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CDC16 CHAMP1 DCUN1D2-AS UPF3A RASA3 LOC105370384 GC13P114279
GH13H113296 1.2 ENCODE 77 -937.1 -937123 2.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 CDC16 PCID2 TUBGCP3 GAS6-AS2 GAS6 LINC01043 CUL4A SPACA7 LDHBP1 GAS6-AS1
GH13H114234 1.1 ENCODE 75.7 +0.6 593 1.9 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 CDC16 CHAMP1 UPF3A MIR548AR
GH13H114155 1.3 Ensembl ENCODE dbSUPER 54.2 -80.5 -80483 1 BCOR HDGF ZNF146 YBX1 EBF1 GLI4 ZNF48 ZNF514 BCL11B CTBP1 CDC16 PCID2 CHAMP1 PIR45361 RASA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC16 on UCSC Golden Path with GeneCards custom track

Promoters for CDC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066290 456 1800 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 SP3

Genomic Locations for CDC16 Gene

Genomic Locations for CDC16 Gene
chr13:114,234,845-114,272,723
(GRCh38/hg38)
Size:
37,879 bases
Orientation:
Plus strand
chr13:115,000,362-115,038,198
(GRCh37/hg19)

Genomic View for CDC16 Gene

Genes around CDC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC16 Gene

Proteins for CDC16 Gene

  • Protein details for CDC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13042-CDC16_HUMAN
    Recommended name:
    Cell division cycle protein 16 homolog
    Protein Accession:
    Q13042
    Secondary Accessions:
    • A2A365
    • Q5T8C8
    • Q7Z651
    • Q96AE6
    • Q9Y564

    Protein attributes for CDC16 Gene

    Size:
    620 amino acids
    Molecular mass:
    71656 Da
    Quaternary structure:
    • V-shaped homodimer. Interacts with CDC26. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with PPP5C and CDC20.

    Three dimensional structures from OCA and Proteopedia for CDC16 Gene

    Alternative splice isoforms for CDC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC16 Gene

Post-translational modifications for CDC16 Gene

  • Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • Ubiquitination at posLast=106106, posLast=154154, and posLast=423423
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDC16 Gene

Domains & Families for CDC16 Gene

Gene Families for CDC16 Gene

Protein Domains for CDC16 Gene

Suggested Antigen Peptide Sequences for CDC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q13042

UniProtKB/Swiss-Prot:

CDC16_HUMAN :
  • TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.
  • Belongs to the APC6/CDC16 family.
Domain:
  • TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.
Family:
  • Belongs to the APC6/CDC16 family.
genes like me logo Genes that share domains with CDC16: view

Function for CDC16 Gene

Molecular function for CDC16 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for CDC16 Gene

Gene Ontology (GO) - Molecular Function for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16648845
genes like me logo Genes that share ontologies with CDC16: view
genes like me logo Genes that share phenotypes with CDC16: view

Animal Model Products

CRISPR Products

miRNA for CDC16 Gene

miRTarBase miRNAs that target CDC16

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC16 Gene

Localization for CDC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC16 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC16 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endosome 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome TAS,IDA 7736578
genes like me logo Genes that share ontologies with CDC16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDC16 Gene

Pathways & Interactions for CDC16 Gene

SuperPathways for CDC16 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC16: view

UniProtKB/Swiss-Prot Q13042-CDC16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC16 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 7736578
GO:0007049 cell cycle IEA --
GO:0007088 regulation of mitotic nuclear division TAS 7736578
GO:0008283 cell proliferation TAS 7736578
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with CDC16: view

Drugs & Compounds for CDC16 Gene

No Compound Related Data Available

Transcripts for CDC16 Gene

Unigene Clusters for CDC16 Gene

Cell division cycle 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: -
SP9: -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b · 19c · 19d ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -
SP7: - - -
SP8:
SP9: - -
SP10: - -
SP11: - -
SP12: -
SP13: - -
SP14:

Relevant External Links for CDC16 Gene

GeneLoc Exon Structure for
CDC16
ECgene alternative splicing isoforms for
CDC16

Expression for CDC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC16 Gene

Protein differential expression in normal tissues from HIPED for CDC16 Gene

This gene is overexpressed in Breast (14.9), NK cells (8.2), and Lung (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC16 Gene



Protein tissue co-expression partners for CDC16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC16 Gene:

CDC16

SOURCE GeneReport for Unigene cluster for CDC16 Gene:

Hs.374127

Evidence on tissue expression from TISSUES for CDC16 Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with CDC16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC16 Gene

Orthologs for CDC16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC16 33 34
  • 99.3 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC16 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDC16 33 34
  • 91.34 (n)
cow
(Bos Taurus)
Mammalia CDC16 33 34
  • 90.75 (n)
mouse
(Mus musculus)
Mammalia Cdc16 33 16 34
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Cdc16 33
  • 87.1 (n)
chicken
(Gallus gallus)
Aves CDC16 33 34
  • 83.23 (n)
lizard
(Anolis carolinensis)
Reptilia CDC16 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc16 33
  • 79.61 (n)
Str.17391 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23806 33
zebrafish
(Danio rerio)
Actinopterygii cdc16 33 34
  • 72.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004623 33
  • 54.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta cdc16 35 33 34
  • 51.54 (n)
worm
(Caenorhabditis elegans)
Secernentea emb-27 35 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC16 33 34 36
  • 46.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR168W 33
  • 46.11 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08009g 33
  • 45.35 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC6 33
  • 52.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut9 33
  • 48.75 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01377 33
  • 44.96 (n)
Species where no ortholog for CDC16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC16 Gene

ENSEMBL:
Gene Tree for CDC16 (if available)
TreeFam:
Gene Tree for CDC16 (if available)

Paralogs for CDC16 Gene

No data available for Paralogs for CDC16 Gene

Variants for CDC16 Gene

Sequence variations from dbSNP and Humsavar for CDC16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000204352 -- 114,256,817(+) TGCTT(C/T)AGAGA intron-variant
rs1000252636 -- 114,249,199(+) GCGCC(A/G)CCTAG intron-variant
rs1000568434 -- 114,238,476(+) CCAGC(A/G)GTTAT intron-variant
rs1000671314 -- 114,234,101(+) ACCAC(A/G)GGTCA upstream-variant-2KB
rs1000709586 -- 114,234,135(+) AATCC(A/G)TGGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDC16 Gene

Variant ID Type Subtype PubMed ID
nsv832728 CNV gain 17160897
nsv563534 CNV gain 21841781
nsv563533 CNV loss 21841781
nsv563532 CNV gain 21841781
nsv521609 CNV gain 19592680
nsv456143 CNV gain 19166990
nsv1120434 CNV deletion 24896259
nsv1050622 CNV gain 25217958
nsv1043111 CNV gain 25217958
esv3633644 CNV gain 21293372
esv3633643 CNV gain 21293372
esv3633642 CNV gain 21293372
esv3582871 CNV gain 25503493
esv25715 CNV gain+loss 19812545
dgv1748n100 CNV gain 25217958
dgv1747n100 CNV gain 25217958
dgv1746n100 CNV gain 25217958
dgv1745n100 CNV gain 25217958

Variation tolerance for CDC16 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC16 Gene

Disorders for CDC16 Gene

Relevant External Links for CDC16

Genetic Association Database (GAD)
CDC16
Human Genome Epidemiology (HuGE) Navigator
CDC16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC16

No disorders were found for CDC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC16 Gene

Publications for CDC16 Gene

  1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. (PMID: 7736578) Tugendreich S … Hieter P (Cell 1995) 2 3 4 22 60
  2. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. (PMID: 9405394) Ollendorff V … Donoghue DJ (The Journal of biological chemistry 1997) 3 4 22 60
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L … Barford D (Nature 2014) 3 4 60
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60
  5. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. (PMID: 19668213) Wang J … Schulman BA (Nature structural & molecular biology 2009) 3 4 60

Products for CDC16 Gene

Sources for CDC16 Gene

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