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Aliases for CDC16 Gene

Aliases for CDC16 Gene

  • Cell Division Cycle 16 2 3
  • APC6 3 4 6
  • Anaphase-Promoting Complex Subunit 6 3 4
  • Cyclosome Subunit 6 3 4
  • CDC16Hs 3 4
  • ANAPC6 3 4
  • CDC16 (Cell Division Cycle 16, S. Cerevisiae, Homolog) 2
  • CDC16 Cell Division Cycle 16 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 16 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 16 Homolog 3
  • Anaphase-Promoting Complex, Subunit 6 3
  • Cell Division Cycle 16 Homolog 3
  • Anaphase-Promoting Complex 2
  • CDC16 Homolog 4
  • Subunit 6 2
  • CUT9 3

External Ids for CDC16 Gene

Previous GeneCards Identifiers for CDC16 Gene

  • GC13P113361
  • GC13P111188
  • GC13P114022
  • GC13P112918
  • GC13P114018
  • GC13P115000
  • GC13P095262

Summaries for CDC16 Gene

Entrez Gene Summary for CDC16 Gene

  • This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC16 Gene

CDC16 (Cell Division Cycle 16) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and PAK Pathway.

UniProtKB/Swiss-Prot for CDC16 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC16 Gene

Genomics for CDC16 Gene

Regulatory Elements for CDC16 Gene

Genomic Location for CDC16 Gene

Start:
114,234,845 bp from pter
End:
114,272,723 bp from pter
Size:
37,879 bases
Orientation:
Plus strand

Genomic View for CDC16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC16 Gene

Proteins for CDC16 Gene

  • Protein details for CDC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13042-CDC16_HUMAN
    Recommended name:
    Cell division cycle protein 16 homolog
    Protein Accession:
    Q13042
    Secondary Accessions:
    • A2A365
    • Q5T8C8
    • Q7Z651
    • Q96AE6
    • Q9Y564

    Protein attributes for CDC16 Gene

    Size:
    620 amino acids
    Molecular mass:
    71656 Da
    Quaternary structure:
    • V-shaped homodimer. Interacts with CDC26. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with PPP5C and CDC20.

    Three dimensional structures from OCA and Proteopedia for CDC16 Gene

    Alternative splice isoforms for CDC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC16 Gene

Proteomics data for CDC16 Gene at MOPED

Post-translational modifications for CDC16 Gene

  • Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • Ubiquitination at Lys106, Lys154, and Lys423
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC16 Gene

No data available for DME Specific Peptides for CDC16 Gene

Domains for CDC16 Gene

Gene Families for CDC16 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for CDC16 Gene

Suggested Antigen Peptide Sequences for CDC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q13042

UniProtKB/Swiss-Prot:

CDC16_HUMAN :
  • Q13042
Domain:
  • TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.
Family:
  • Belongs to the APC6/CDC16 family.
Similarity:
  • Contains 14 TPR repeats.
genes like me logo Genes that share domains with CDC16: view

Function for CDC16 Gene

Molecular function for CDC16 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with CDC16: view

Phenotypes for CDC16 Gene

genes like me logo Genes that share phenotypes with CDC16: view

miRNA for CDC16 Gene

miRTarBase miRNAs that target CDC16

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC16 Gene

Localization for CDC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC16 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC16 Gene COMPARTMENTS Subcellular localization image for CDC16 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
endosome 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 7736578
genes like me logo Genes that share ontologies with CDC16: view

Pathways for CDC16 Gene

SuperPathways for CDC16 Gene

genes like me logo Genes that share pathways with CDC16: view

UniProtKB/Swiss-Prot Q13042-CDC16_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007088 regulation of mitotic nuclear division TAS 7736578
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0008283 cell proliferation TAS 7736578
genes like me logo Genes that share ontologies with CDC16: view

Transcripts for CDC16 Gene

Unigene Clusters for CDC16 Gene

Cell division cycle 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: -
SP9: -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b · 19c · 19d ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -
SP7: - - -
SP8:
SP9: - -
SP10: - -
SP11: - -
SP12: -
SP13: - -
SP14:

Relevant External Links for CDC16 Gene

GeneLoc Exon Structure for
CDC16
ECgene alternative splicing isoforms for
CDC16

Expression for CDC16 Gene

mRNA expression in normal human tissues for CDC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC16 Gene

SOURCE GeneReport for Unigene cluster for CDC16 Gene Hs.374127

genes like me logo Genes that share expressions with CDC16: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC16 Gene

Orthologs for CDC16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC16 35
  • 99.3 (n)
  • 100 (a)
CDC16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC16 35
  • 90.75 (n)
  • 97.58 (a)
CDC16 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC16 35
  • 91.34 (n)
  • 97.9 (a)
CDC16 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc16 35
  • 88.23 (n)
  • 95.48 (a)
Cdc16 16
Cdc16 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC16 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cdc16 35
  • 87.1 (n)
  • 95.97 (a)
chicken
(Gallus gallus)
Aves CDC16 35
  • 83.23 (n)
  • 92.1 (a)
CDC16 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC16 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23806 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc16 35
  • 79.61 (n)
  • 88.83 (a)
Str.17391 35
zebrafish
(Danio rerio)
Actinopterygii cdc16 35
  • 72.29 (n)
  • 81.34 (a)
cdc16 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004623 35
  • 54.95 (n)
  • 50.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdc16 35
  • 51.54 (n)
  • 46.67 (a)
cdc16 36
  • 36 (a)
OneToOne
cdc16 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea emb-27 36
  • 21 (a)
OneToOne
emb-27 37
  • 24 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR168W 35
  • 46.11 (n)
  • 37.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC16 35
  • 46.27 (n)
  • 33.98 (a)
CDC16 36
  • 22 (a)
OneToOne
CDC16 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08009g 35
  • 45.35 (n)
  • 35.05 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC6 35
  • 52.01 (n)
  • 44.36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01377 35
  • 44.96 (n)
  • 36.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut9 35
  • 48.75 (n)
  • 37.73 (a)
Species with no ortholog for CDC16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC16 Gene

ENSEMBL:
Gene Tree for CDC16 (if available)
TreeFam:
Gene Tree for CDC16 (if available)

Paralogs for CDC16 Gene

No data available for Paralogs for CDC16 Gene

Variants for CDC16 Gene

Sequence variations from dbSNP and Humsavar for CDC16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs8809 -- 114,265,239(+) TATAT(C/T)GGTAA synonymous-codon, reference, intron-variant, nc-transcript-variant
rs13159 -- 114,265,173(+) GATGA(C/T)ACATT synonymous-codon, reference, intron-variant, nc-transcript-variant
rs723395 -- 114,256,539(+) TCTGA(C/G)TCTGC intron-variant
rs995232 -- 114,254,844(-) gaggg(C/T)gtaaa intron-variant
rs995233 -- 114,254,834(-) agagg(A/C)gtgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC16 Gene

Variant ID Type Subtype PubMed ID
nsv901106 CNV Gain 21882294
nsv832728 CNV Gain 17160897
nsv901114 CNV Gain 21882294
nsv901115 CNV Gain 21882294
esv25715 CNV Gain+Loss 19812545
nsv521609 CNV Gain 19592680
nsv901116 CNV Gain 21882294
nsv456143 CNV Gain 19166990

Relevant External Links for CDC16 Gene

HapMap Linkage Disequilibrium report
CDC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC16 Gene

Disorders for CDC16 Gene

Relevant External Links for CDC16

Genetic Association Database (GAD)
CDC16
Human Genome Epidemiology (HuGE) Navigator
CDC16
genes like me logo Genes that share disorders with CDC16: view

No data available for UniProtKB/Swiss-Prot for CDC16 Gene

Publications for CDC16 Gene

  1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. (PMID: 7736578) Tugendreich S. … Hieter P. (Cell 1995) 2 3 4 23
  2. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PMID: 9405394) Ollendorff V. … Donoghue D.J. (J. Biol. Chem. 1997) 3 4 23
  3. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C. … Peters J.-M. (EMBO J. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4

Products for CDC16 Gene

Sources for CDC16 Gene

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