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CCR6 Gene

protein-coding GIFtS: 60

GC06P167383

chemokine (C-C motif) receptor 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: STRL22)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BN-1 ^¹, ²
CC-CKR-6 ^³
CCR-6 ^³
CD196 ^¹, ²
CKR-L3 ^¹, ², ³
CKR6 ^²
CKRL3 ^², ³, ⁵
CMKBR6 ^¹, ², ³, ⁵
DCR2 ^¹, ²
DRY-6 ^¹, ²
DRY6 ^³
GPR-CY4 ^¹, ², ³
GPR29 ^¹, ², ³, ⁵
GPRCY4 ^², ³, ⁵
OTTHUMP00000017618 ^²
OTTHUMP00000017619 ^²
STRL22 ^², ³

Descriptions
C-C CKR-6 ^³
CD196 antigen ^³
Chemokine receptor-like 3 ^², ³
G protein-coupled receptor 29 ^²
G-protein coupled receptor 29 ^³
LARC receptor ^³
chemokine (C-C motif) receptor 6 ^²
chemokine (C-C) receptor 6 ^²
seven-transmembrane receptor, lymphocyte, 22 ^²

External Ids
HGNC: 1607¹
Entrez Gene: 1235²
UniProtKB: P51684³
Ensembl: ENSG00000112486⁷

Search outside databases for aliases for CCR6 gene

Previous GC identifers: GC06P166889 GC06P167409 GC06P167445

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCR6:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven

transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed

by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage

inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for

B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration

and recruitment of dentritic and T cells during inflammatory and immunological responses.

Alternatively spliced transcript variants that encode the same protein have been described for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684

Function: Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces

a signal by increasing the intracellular calcium ions level

Gene Wiki entry for CCR6 (C-C_chemokine_receptor_type_6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCR6 gene

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

CCR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P167383: (about GC identifiers)

Start:	167,332,883 bp from pter
End:	167,472,619 bp from pter
Size:	139,737 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007422.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684 (See protein sequence)

Recommended Name: C-C chemokine receptor type 6

Size: 374 amino acids; 42494 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Caution: It is uncertain whether Met-1 or Met-6 is the initiator

Secondary accessions: P78553 Q92846

REFSEQ proteins (2 alternative transcripts):

NP_004358.2 NP_113597.2

ENSEMBL proteins:

ENSP00000283506 ENSP00000383715 ENSP00000343952 ENSP00000339393

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CCR6 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CCR6)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9186513
GO:0005887	integral to plasma membrane	TAS	9186513

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Antibodies for CCR6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CCR6
	Sigma-Aldrich Antibodies for CCR6
	R&D Systems Antibodies for CCR6
	Antibodies from Abcam (CCR6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CCR6)
	Novus Biologicals Antibodies for CCR6

Assays for CCR6:

	Invitrogen Assays for CCR6
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51684

ProtoNet protein and cluster: P51684

2 Blocks protein families:

IPB000355 Chemokine receptor signature

IPB004067 C-C chemokine receptor type 6 signature

UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCR6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCR6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004367

Applied Biosystems Silencer® siRNAs for CCR6

Sigma-Aldrich siRNA and siRNA Panels for CCR6

Sigma-Aldrich shRNA Panels and shRNA for CCR6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CCR6
		Millipore Clones for the Expression of CCR6

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004367
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004367
untagged cDNA clones in CMV expression vector (see all 2): NM_004367

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004367

UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684

Function: Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces

a signal by increasing the intracellular calcium ions level

Induction: By interleukin-2

Genatlas biochemistry entry for CCR6:

chemokine CC beta receptor,expressed in lymphocyte and monocyte,highly homolog to

EBI1,IL8RA,IL8RB,G protein coupled receptor superfamily

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ccr6):

hematopoietic system

immune system

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9186513
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0016493	C-C chemokine receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CCR6

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cell motion	TAS	9186513
GO:0006935	chemotaxis	TAS	11001880
GO:0006959	humoral immune response	TAS	11001880
GO:0006968	cellular defense response	TAS	10521347
GO:0007165	signal transduction	TAS	9186513

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CCR6 available from Tocris Bioscience
6 Novoseek chemical compound relationships for CCR6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
larc	90.90	20	9169459 (4), 11120783 (3), 11035086 (1), 9365118 (1) (see all 11)
mip-3alpha	89.26	4	18490742 (1), 17617631 (1)
rantes	66.22	6	10679062 (2), 17133532 (1), 11994442 (1), 9169459 (1)
tarc	45.98	2	9365118 (1), 9169459 (1)
ccl4	29.46	1	17133532 (1)
calcium	13.19	4	9886385 (2), 10577517 (1), 16365449 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCR6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCR6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004367

Sigma-Aldrich siRNA and siRNA Panels for CCR6

Sigma-Aldrich shRNA Panels and shRNA for CCR6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004367 NM_031409

REFSEQ mRNAs for CCR6 gene (2 alternative transcripts):

NM_004367.5 NM_031409.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004367 NM_031409

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004367
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004367
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004367

Additional cDNA sequence:

AK223494.1 AK293015.1 AY242126.1 BC037960.1 U60000.1 U68030.1 U68031.1

5 DOTS entries:

DT.121386105 DT.100749397 DT.95359744 DT.121386128 DT.432235

24/78 AceView cDNA sequences (see all 78 ):

AI566733 BM874378 AY242126 NM_031409 BU193028 BC037960 AA720658 AA292126

BG289619 NM_004367 BE550052 U68031 BU625682 BP337163 AA865712 BQ427775

AW575605 CD558603 CB306621 AW404691 AW160364 BQ082444 BF942057 U60000

highest scoring ESTs for CCR6:

U68030 AW404691 AW575605 BC037960 BX279700 N57964 U60000 AI808029 AK223494 AU098961

Unigene Cluster for CCR6:

Chemokine (C-C motif) receptor 6

Hs.46468 [show with all ESTs]

Unigene Representative Sequence: NM_031409

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000283506 ENST00000400926 ENST00000341935 ENST00000349984

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CCR6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCR6

¹ / ² / ³

4 probe-sets matching CCR6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33553_r_at²^{, 3}	U95-A	1	1.00	1.00	0.86	1.35	U45984	0.20	1.00	0.72	1
458_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.98	U68030	1.00	1.00	1.00	1
206983_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004367	0.60	1.00	0.82	1
206983_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAAATGTGG

SOURCE GeneReport for Unigene cluster: Hs.46468
Expression variation in blood from EXPOLDB for CCR6
UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684
Tissue specificity: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes,
T-cells and B-cells but not in natural killer cells, monocytes or granulocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCR6 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCR6¹	--	chemokine (C-C motif) receptor 6	78.16(n) 80.75(a)	484080 XM_541197.2 XP_541197.2
cow (Bos taurus)	CCR6¹	--	chemokine (C-C motif) receptor 6	77.15(n) 79.67(a)	519716 XM_597941.2 XP_597941.2
rat (Rattus norvegicus)	Ccr6¹	--	chemokine (C-C motif) receptor 6	76.07(n) 76.44(a)	308163 NM_001013145.1 NP_001013163.1
mouse (Mus musculus)	Ccr6^{1, 5}	17⁵	chemokine (C-C motif) receptor 6^{1, 5}	75.32(n)¹ 75.41(a)¹	12458¹ NM_009835.3¹ NP_033965.1¹ AB009369⁵ AB016031⁵ (see all 12)
chicken (Gallus gallus)	CCR6¹	--	chemokine (C-C motif) receptor 6	63.7(n) 60.06(a)	769278 XM_001232062.1 XP_001232063.1

About this table Species with no ortholog for CCR6

ENSEMBL Gene Tree for CCR6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCR6 gene

CCR7² CCR9² CCR10² CXCR6² CCRL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/297 NCBI SNPs in CCR6 are shown (see all 297 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 117)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2021033^1,2	A,C,F,H,O	167444229(-)	`GGATAC/TGGCAG`	1	--	ng5¹		16	EU EA WA NA	1472
--	rs2023305^1,2	A,C,F,H,O	167444888(-)	`ATAAAG/AGAGAA`	1	--	ng5¹ trp³		11	MN EU EA WA NA	1174
--	rs1012657^1,2	A,C,F,H,O	167445132(-)	`TTTCTT/GTGTTT`	1	--	ng5¹		10	MN EU EA WA NA	1098
	rs3093008^1,2	A,C,F,H	167469526(+)	`CCTCTA/GCTTTC`	2	--	ut5¹ ese³		8	NA EU EA WA	600
--	rs1012656^1,2	A,C,F,H	167445293(-)	`TTCACC/GCATAC`	1	--	ut5¹		7	MN EU EA WA	956
	rs3093023^1,2	A,C,F,H	167454280(+)	`GAACAG/ATGTGA`	2	--	int¹ ng5¹		8	NA EU EA WA	600
--	rs6907666^1,2	A,C,F,H	167443385(+)	`ctgccG/Aatgca`	1	--	ng5¹		8	EU EA WA	836
--	rs1556413^1,2	C,F,H,O	167444733(-)	`AACCTC/TGTAAT`	1	--	ng5¹		10	MN EU EA WA NA	1100
--	rs9348223^1,2	A,C,F,H	167444379(+)	`ATTctT/Cgggaa`	1	--	ng5¹		8	EU EA WA	836
--	rs9366094^1,2	A,C,F	167472390(+)	`TGACAA/GAGCGA`	2	--	ut3¹ ese³		1	NA	40

About this table

HapMap Linkage Disequilibrium images for CCR6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601835

10/27 Novoseek disease relationships for CCR6 gene (see all 27 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
b-all	40.23	1	11368435 (1)
necrosis	39.44	1	11090084 (1)
inflammation	35.72	5	16215992 (2), 17379855 (1), 17178254 (1)
rheumatoid arthritis	34.32	3	12695561 (2), 16207316 (1)
psoriasis	32.17	6	15315355 (3), 10843722 (1), 15550147 (1)
skin lesion	27.85	1	15315355 (1)
tumors	24.95	16	18465142 (4), 16622267 (3), 15334073 (1), 19340288 (1) (see all 9)
lymphoma	24.37	3	12514792 (2), 11368435 (1)
lymphoproliferative disorders	23.11	3	12614207 (1), 15621766 (1), 11368435 (1)
liver metastases	21.96	7	16622267 (3), 16641550 (2), 12791091 (1)

About this table

Human Genome Epidemiology Navigator: CCR6 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/201 PubMed articles for CCR6 gene (see all 201 ):

Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PubMed id 8886020)^{1, 2, 3, 4} Zaballos A....Marquez G. (1996)
Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC. (PubMed id 9169459)^{1, 3, 4} Baba M.... Yoshie O. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. (PubMed id 9070937)^{3, 4} Liao F.... Farber J.M. (1997)
Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer. (PubMed id 16622267)^{1, 3} Ghadjar P....Keilholz U. (2006)
Chemokine receptor CCR6 expression level and aggressiveness of prostate cancer. (PubMed id 18465142)^{1, 3} Ghadjar P....Keilholz U. (2008)
Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling. (PubMed id 15591779)^{1, 3} Ai L.S....Liao F. (2004)
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. (PubMed id 12193700)^{1, 3} Maki W....Hwang S.T. (2002)
CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas. (PubMed id 12514792)^{1, 3} Rodig S.J....Dorfman D.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1235	HGNC: 1607	AceView: CCR6	Ensembl:ENSG00000112486	euGenes: HUgn1235
ECgene: CCR6	H-InvDB: CCR6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/CC_chemokine_receptors

Licensable Technologies for CCR6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CCR6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCR6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCR6		Antibodies for CCR6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CCR6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for CCR6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCR6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CCR6 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for CCR6

Summaries
for CCR6

Genomic Location
for CCR6

Proteins
for CCR6

Protein Domains/
Families
for CCR6

Gene Function
for CCR6

Pathways & Interactions
for CCR6

Drugs & Compounds
for CCR6

Transcripts
for CCR6

Expression
for CCR6

Orthologs
for CCR6

Paralogs
for CCR6

SNPs/Variants
for CCR6

Disorders & Mutations
for CCR6

Medical News
for CCR6

Publications
for CCR6

Search for CCR6

Genome Databases showing CCR6

Other Databases showing CCR6

Specialized Databases showing CCR6

Licensable Technologies
for CCR6

Services
for CCR6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCR6 (Gene Symbol)
BN-1
CC-CKR-6
CCR-6
CD196
CKR-L3
CKR6
CKRL3
CMKBR6
DCR2
DRY-6
DRY6
GPR-CY4
GPR29
GPRCY4
OTTHUMP00000017618
OTTHUMP00000017619
STRL22
C-C CKR-6
CD196 antigen
Chemokine receptor-like 3
G protein-coupled receptor 29
G-protein coupled receptor 29
LARC receptor
chemokine (C-C motif) receptor 6
chemokine (C-C) receptor 6
seven-transmembrane receptor, lymphocyte, 22

CCR6 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor CCR6

Summariesfor CCR6

Genomic Locationfor CCR6

Proteinsfor CCR6

Protein Domains/Familiesfor CCR6

Gene Functionfor CCR6

Pathways & Interactionsfor CCR6

Drugs & Compoundsfor CCR6

Transcriptsfor CCR6

Expression for CCR6

Orthologsfor CCR6

Paralogsfor CCR6

SNPs/Variantsfor CCR6

Disorders & Mutationsfor CCR6

Medical Newsfor CCR6

Publicationsfor CCR6

Search for CCR6

Genome Databases showing CCR6

Other Databases showing CCR6

Specialized Databases showing CCR6

Licensable Technologiesfor CCR6

Servicesfor CCR6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCR6

Summaries
for CCR6

Genomic Location
for CCR6

Proteins
for CCR6

Protein Domains/
Families
for CCR6

Gene Function
for CCR6

Pathways & Interactions
for CCR6

Drugs & Compounds
for CCR6

Transcripts
for CCR6

Expression
for CCR6

Orthologs
for CCR6

Paralogs
for CCR6

SNPs/Variants
for CCR6

Disorders & Mutations
for CCR6

Medical News
for CCR6

Publications
for CCR6

Licensable Technologies
for CCR6

Services
for CCR6