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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYYR1 Gene

protein-coding GIFtS: 44
GCID: GC21M027838

cysteine/tyrosine-rich 1

(Previous name: cysteine and tyrosine-rich 1 )
(Previous symbol: C21orf95)

Explore 5 diseases affiliated with
CYYR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cysteine/Tyrosine-Rich 1¹ ²
C21orf95¹ ² ³
Cysteine And Tyrosine-Rich 1¹ ²
Proline-Rich Domain-Containing Protein² ³
Cysteine And Tyrosine-Rich Protein 1²

External Ids:	HGNC: 16274¹	Entrez Gene: 116159²	Ensembl: ENSG00000166265⁷	UniProtKB: Q96J86³

Export aliases for CYYR1 gene to outside databases

Previous GC identifers: GC21M024417 GC21M026760 GC21M013243

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for CYYR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYYR1 gene promoter:
Bach1 HSF1 (long) FOXO3 FOXO3b POU2F1 HFH-1 POU2F1a POU2F1b FOXO3a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYYR1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYYR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYYR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q21.2

CYYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYYR1 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21M027838: view genomic region (about GC identifiers)

Start:	27,838,528 bp from pter	End:	27,945,603 bp from pter
Size:	107,076 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CYYR1_HUMAN, Q96J86 (See protein sequence)

Recommended Name: Cysteine and tyrosine-rich protein 1 precursor

Size: 154 amino acids; 16626 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=BAB70764.1; Type=Erroneous initiation;

Secondary accessions: B2R845 Q53ER3 Q5JPD0 Q96NV7

Alternative splicing: 2 isoforms: Q96J86-1 Q96J86-2

Explore the universe of human proteins at neXtProt for CYYR1: NX_Q96J86

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96J86

CYYR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443186.1

ENSEMBL proteins:

ENSP00000299340 ENSP00000382918 ENSP00000401313

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	NAS	--

CYYR1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYYR1 for domains About GeneDecksing

1 InterPro domain/family:

IPR022640 CYYR1

Graphical View of Domain Structure for InterPro Entry Q96J86

ProtoNet protein and cluster: Q96J86

UniProtKB/Swiss-Prot: CYYR1_HUMAN, Q96J86

Similarity: Belongs to the CYYR1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

CYYR1 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYYR1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

CYYR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CYYR1 gene:

NM_052954.2

Unigene Cluster for CYYR1:

Cysteine/tyrosine-rich 1

Hs.743438 [show with all ESTs]

Unigene Representative Sequence: NM_052954

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000299340(uc002ymd.3 uc011ack.2 uc002yme.3) ENST00000400043

ENST00000435845

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Additional cDNA sequence:

AF401639.1 AK054581.1 AK223576.1 AK304124.1 AK313231.1 AL833200.1 AY061853.1 BC036761.1

3 DOTS entries:

DT.308018 DT.100765198 DT.101974542

24/87 AceView cDNA sequences (see all 87):

AI143503 CB267520 CA406765 CR612850 AY061853 AI269294 AI122838 BC036761

CK905667 CA391068 BX436678 AI800696 BE046142 NM_052954 AA854283 AI184636

AA719885 AI911750 AI433908 BI962525 BE328343 BU069877 AF401639 BE328797

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CYYR1 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c
SP1:									-				-				-
SP2:									-				-
SP3:									-				-				-
SP4:													-				-
SP5:									-

ECgene alternative splicing isoforms for CYYR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYYR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTATAAA

About this image

CYYR1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYYR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYYR1

SOURCE GeneReport for Unigene cluster: Hs.743438

UniProtKB/Swiss-Prot: CYYR1_HUMAN, Q96J86

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for CYYR1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYYR1 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Cyyr1^{1 , 5}	cysteine and tyrosine-rich protein 1^{1, 5}	82.25(n)¹ 81.82(a)¹	16 (47.45 cM)⁵ 224405¹ NM_144853.3¹ NP_659102.1¹ 85421533⁵
chicken (Gallus gallus)	Aves	CYYR1¹	cysteine/tyrosine-rich 1	75.44(n) 78.2(a)	770067 XM_001233378.2 XP_001233379.2
African clawed frog (Xenopus laevis)	Amphibia	Xl.5729²	Xenopus laevis transcribed sequence with weak similarity more	74.16(n)	BJ622637.1
zebrafish (Danio rerio)	Actinopterygii	cyyr1¹	cysteine and tyrosine-rich protein 1	63.21(n) 60.74(a)	405818 NM_212882.1 NP_998047.1

ENSEMBL Gene Tree for CYYR1 (if available)
TreeFam Gene Tree for CYYR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17002176^1,2	C,F,H	--	13243587(+)	`TAGCCA/GCAGTG`	1	--	int¹ ese³		18		NA NS EA WA	2242
rs58239537^1,2		--	13243635(+)	`AAAGCA/GTATGT`	1	--	int¹		0	--	--	--	--
rs1478108^1,2	C,F,O	--	13243814(+)	`GTTATA/GTTTCA`	1	--	int¹		2		EA NA	204
rs2830238^1,2	C,F,O	--	13243912(+)	`ACAGGT/CACTAT`	1	--	int¹		7		NA WA CSA	279
rs219641^1,2	C,F,A,H	--	13244345(+)	`GAATCT/CGAACT`	1	--	int¹		24		MN NA NS EA WA	2568
rs77041278^1,2	F	--	13244669(+)	`CAACTC/GTTTCT`	1	--	int¹		1		EA	120
rs114334580^1,2	C,F	--	13244756(+)	`GAACCC/TATCTA`	1	--	int¹		1		WA	118
rs219642^1,2	C,F,A,H	--	13244783(+)	`TCCCTT/GCTGGA`	1	--	int¹ ese³		14		NA WA	578
rs219643^1,2	C,F,A,H	--	13245130(+)	`TCTTCC/TCTGAA`	1	--	int¹ ese³		17		NA NS EA WA	934
rs13052857^1,2	H	--	13245352(+)	`TCGCCC/GATTGG`	1	--	int¹ ese³		5		NS EA NA	432

HapMap Linkage Disequilibrium report for CYYR1 (27838528 - 27945603 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYYR1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYYR1 for disorders About GeneDecksing

5 diseases for CYYR1: About MalaCards

neuroendocrine tumor hepatitis b hepatocellular carcinoma hepatitis

carcinoma

Human Genome Epidemiology (HuGE) Navigator: CYYR1 (1 document)

Export disorders for CYYR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYYR1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CYYR1)

Utopia: connect your pdf to the dynamic
world of online information

Nineteen additional unpredicted transcripts from human chromosome 21. (PubMed id 12036297)^{1, 2, 3} Reymond A....Antonarakis S.E. (2002)
Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate- specific genes. (PubMed id 12062809)^{1, 2, 3} Vitale L.... Zannotti M. (2002)
Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors. (PubMed id 17442112)^{1, 2, 9} Vitale L....Strippoli P. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)¹ Wilk J.B....Stricker B.H. (2012)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 116159	HGNC: 16274	AceView: CYYR1	Ensembl:ENSG00000166265	euGenes: HUgn116159
ECgene: CYYR1	H-InvDB: CYYR1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYYR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYYR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CYYR1 gene:
Search GeneIP for patents involving CYYR1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CYYR1 gene at Home site.

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CYYR1 Gene

cysteine/tyrosine-rich 1

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CYYR1 Gene

cysteine/tyrosine-rich 1

Aliasesfor CYYR1 gene

Summariesfor CYYR1 gene

Genomic Viewsfor CYYR1 gene

Proteinsfor CYYR1 gene

Protein Domains /Familiesfor CYYR1 gene

Functionfor CYYR1 gene

Pathways & Interactionsfor CYYR1 gene

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for CYYR1 gene

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