Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYYR1 Gene

Aliases for CYYR1 Gene

  • Cysteine/Tyrosine-Rich 1 2 3
  • Proline-Rich Domain-Containing Protein 3 4
  • Cysteine And Tyrosine-Rich 1 2 3
  • C21orf95 3 4
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,2bis,3,4 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3,4b 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3b 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,4 3
  • Cysteine And Tyrosine-Rich Protein 1 3

External Ids for CYYR1 Gene

Previous HGNC Symbols for CYYR1 Gene

  • C21orf95

Previous GeneCards Identifiers for CYYR1 Gene

  • GC21M024417
  • GC21M026760
  • GC21M027838
  • GC21M013243

Summaries for CYYR1 Gene

GeneCards Summary for CYYR1 Gene

CYYR1 (Cysteine/Tyrosine-Rich 1) is a Protein Coding gene.

Gene Wiki entry for CYYR1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYYR1 Gene

Genomics for CYYR1 Gene

Regulatory Elements for CYYR1 Gene

Genomic Location for CYYR1 Gene

Start:
26,466,209 bp from pter
End:
26,573,284 bp from pter
Size:
107,076 bases
Orientation:
Minus strand

Genomic View for CYYR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYYR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYYR1 Gene

Proteins for CYYR1 Gene

  • Protein details for CYYR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J86-CYYR1_HUMAN
    Recommended name:
    Cysteine and tyrosine-rich protein 1
    Protein Accession:
    Q96J86
    Secondary Accessions:
    • A0A059TD09
    • A8MTU9
    • B2R845
    • Q53ER3
    • Q5JPD0
    • Q96NV7
    • R9QAJ4
    • W8CQB3

    Protein attributes for CYYR1 Gene

    Size:
    154 amino acids
    Molecular mass:
    16626 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB70764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYYR1 Gene

neXtProt entry for CYYR1 Gene

Proteomics data for CYYR1 Gene at MOPED

Post-translational modifications for CYYR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYYR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYYR1 Gene

Domains for CYYR1 Gene

Protein Domains for CYYR1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96J86

UniProtKB/Swiss-Prot:

CYYR1_HUMAN :
  • Q96J86
Family:
  • Belongs to the CYYR1 family.
genes like me logo Genes that share domains with CYYR1: view

No data available for Gene Families for CYYR1 Gene

Function for CYYR1 Gene

Gene Ontology (GO) - Molecular Function for CYYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CYYR1: view

miRNA for CYYR1 Gene

miRTarBase miRNAs that target CYYR1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYYR1 Gene

Localization for CYYR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYYR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYYR1 Gene COMPARTMENTS Subcellular localization image for CYYR1 gene
Compartment Confidence
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CYYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYYR1: view

Pathways for CYYR1 Gene

SuperPathways for CYYR1 Gene

No Data Available

Interacting Proteins for CYYR1 Gene

Gene Ontology (GO) - Biological Process for CYYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CYYR1: view

No data available for Pathways by source for CYYR1 Gene

Transcripts for CYYR1 Gene

Unigene Clusters for CYYR1 Gene

Cysteine/tyrosine-rich 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYYR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for CYYR1 Gene

GeneLoc Exon Structure for
CYYR1
ECgene alternative splicing isoforms for
CYYR1

Expression for CYYR1 Gene

mRNA expression in normal human tissues for CYYR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CYYR1 Gene Hs.37445

mRNA Expression by UniProt/SwissProt for CYYR1 Gene

Q96J86-CYYR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with CYYR1: view

No data available for mRNA differential expression in normal tissues and Protein expression for CYYR1 Gene

Orthologs for CYYR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYYR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYYR1 35
  • 99.57 (n)
  • 98.7 (a)
CYYR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYYR1 36
  • 33 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYYR1 35
  • 87.01 (n)
  • 87.66 (a)
CYYR1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyyr1 35
  • 82.25 (n)
  • 81.82 (a)
Cyyr1 16
Cyyr1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYYR1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyyr1 35
  • 80.3 (n)
  • 78.57 (a)
chicken
(Gallus gallus)
Aves CYYR1 35
  • 75.44 (n)
  • 78.2 (a)
CYYR1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5729 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cyyr1 35
  • 68.89 (n)
  • 72.67 (a)
Str.10669 35
zebrafish
(Danio rerio)
Actinopterygii cyyr1 35
  • 61.84 (n)
  • 57.97 (a)
CYYR1 36
  • 44 (a)
OneToOne
Species with no ortholog for CYYR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYYR1 Gene

ENSEMBL:
Gene Tree for CYYR1 (if available)
TreeFam:
Gene Tree for CYYR1 (if available)

Paralogs for CYYR1 Gene

No data available for Paralogs for CYYR1 Gene

Variants for CYYR1 Gene

Sequence variations from dbSNP and Humsavar for CYYR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs222978 -- 26,571,816(+) TAGAA(A/G)GTCAG intron-variant
rs222979 -- 26,572,312(+) GAAAC(C/G)AGATG intron-variant
rs222980 -- 26,574,783(+) CAAAT(A/G)CACAT upstream-variant-2KB
rs7277524 -- 26,569,868(+) AATGT(A/T)GTAGC intron-variant
rs7279736 -- 26,574,270(+) ATGAT(C/G)AGTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYYR1 Gene

Variant ID Type Subtype PubMed ID
nsv913660 CNV Gain 21882294
nsv3481 CNV Insertion 18451855

Relevant External Links for CYYR1 Gene

HapMap Linkage Disequilibrium report
CYYR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYYR1 Gene

Disorders for CYYR1 Gene

Relevant External Links for CYYR1

Genetic Association Database (GAD)
CYYR1
Human Genome Epidemiology (HuGE) Navigator
CYYR1
genes like me logo Genes that share disorders with CYYR1: view

No data available for UniProtKB/Swiss-Prot for CYYR1 Gene

Publications for CYYR1 Gene

  1. Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors. (PMID: 17442112) Vitale L. … Strippoli P. (BMC Cancer 2007) 3 4 23
  2. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A. … Antonarakis S.E. (Genomics 2002) 2 3 4
  3. Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate- specific genes. (PMID: 12062809) Vitale L. … Zannotti M. (Gene 2002) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CYYR1 Gene

Sources for CYYR1 Gene

Back to Top

Content