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Aliases for CYYR1 Gene

Aliases for CYYR1 Gene

  • Cysteine And Tyrosine Rich 1 2 3 5
  • Proline-Rich Domain-Containing Protein 3 4
  • Cysteine/Tyrosine-Rich 1 2 3
  • C21orf95 3 4
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,2bis,3,4 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3,4b 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3b 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,4 3
  • Cysteine And Tyrosine-Rich Protein 1 3

External Ids for CYYR1 Gene

Previous HGNC Symbols for CYYR1 Gene

  • C21orf95

Previous GeneCards Identifiers for CYYR1 Gene

  • GC21M024417
  • GC21M026760
  • GC21M027838
  • GC21M013243

Summaries for CYYR1 Gene

GeneCards Summary for CYYR1 Gene

CYYR1 (Cysteine And Tyrosine Rich 1) is a Protein Coding gene.

Gene Wiki entry for CYYR1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYYR1 Gene

Genomics for CYYR1 Gene

Regulatory Elements for CYYR1 Gene

Enhancers for CYYR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G026569 1.1 FANTOM5 Ensembl ENCODE 6.7 +1.5 1521 4.2 GATA2 SUZ12 POLR2A RBBP5 NR2F2 EZH2 CYYR1 APP ENSG00000273115
GH21G026546 0.6 Ensembl ENCODE 11.5 +26.3 26284 1.2 NR2F2 CYYR1 ENSG00000273115
GH21G026587 0.9 Ensembl ENCODE 6.3 -14.8 -14825 1.0 PKNOX1 ESRRA JUN CEBPB EP300 RFX5 FOXA1 CTBP1 JUND GATA3 CYYR1 GC21M026844 ADAMTS1
GH21G026490 0.4 ENCODE 10.9 +82.2 82226 0.9 TEAD4 CYYR1 ENSG00000273115
GH21G026491 0.4 ENCODE 10.9 +81.5 81519 0.2 EP300 CYYR1 ENSG00000273115
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYYR1 on UCSC Golden Path with GeneCards custom track

Promoters for CYYR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140857 484 1600 SUZ12 POLR2A RBBP5 EZH2

Genomic Location for CYYR1 Gene

Chromosome:
21
Start:
26,466,209 bp from pter
End:
26,573,284 bp from pter
Size:
107,076 bases
Orientation:
Minus strand

Genomic View for CYYR1 Gene

Genes around CYYR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYYR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYYR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYYR1 Gene

Proteins for CYYR1 Gene

  • Protein details for CYYR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J86-CYYR1_HUMAN
    Recommended name:
    Cysteine and tyrosine-rich protein 1
    Protein Accession:
    Q96J86
    Secondary Accessions:
    • A0A059TD09
    • A8MTU9
    • B2R845
    • Q53ER3
    • Q5JPD0
    • Q96NV7
    • R9QAJ4
    • W8CQB3

    Protein attributes for CYYR1 Gene

    Size:
    154 amino acids
    Molecular mass:
    16626 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB70764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYYR1 Gene

neXtProt entry for CYYR1 Gene

Post-translational modifications for CYYR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYYR1 Gene

No data available for DME Specific Peptides for CYYR1 Gene

Domains & Families for CYYR1 Gene

Protein Domains for CYYR1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96J86

UniProtKB/Swiss-Prot:

CYYR1_HUMAN :
  • Belongs to the CYYR1 family.
Family:
  • Belongs to the CYYR1 family.
genes like me logo Genes that share domains with CYYR1: view

No data available for Gene Families for CYYR1 Gene

Function for CYYR1 Gene

Gene Ontology (GO) - Molecular Function for CYYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CYYR1: view
genes like me logo Genes that share phenotypes with CYYR1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYYR1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CYYR1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYYR1 Gene

Localization for CYYR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYYR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYYR1 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for CYYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYYR1: view

Pathways & Interactions for CYYR1 Gene

SuperPathways for CYYR1 Gene

No Data Available

Interacting Proteins for CYYR1 Gene

Gene Ontology (GO) - Biological Process for CYYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CYYR1: view

No data available for Pathways by source and SIGNOR curated interactions for CYYR1 Gene

Drugs & Compounds for CYYR1 Gene

No Compound Related Data Available

Transcripts for CYYR1 Gene

Unigene Clusters for CYYR1 Gene

Cysteine/tyrosine-rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CYYR1

Alternative Splicing Database (ASD) splice patterns (SP) for CYYR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for CYYR1 Gene

GeneLoc Exon Structure for
CYYR1
ECgene alternative splicing isoforms for
CYYR1

Expression for CYYR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYYR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CYYR1 Gene:

CYYR1

SOURCE GeneReport for Unigene cluster for CYYR1 Gene:

Hs.37445

mRNA Expression by UniProt/SwissProt for CYYR1 Gene:

Q96J86-CYYR1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for CYYR1 Gene

  • Heart(4.3)
  • Lymph node(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CYYR1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYYR1 Gene

Orthologs for CYYR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYYR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYYR1 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia CYYR1 34 35
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Cyyr1 34 16 35
  • 82.25 (n)
rat
(Rattus norvegicus)
Mammalia Cyyr1 34
  • 80.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYYR1 35
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYYR1 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYYR1 34 35
  • 75.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyyr1 34
  • 68.89 (n)
Str.10669 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5729 34
zebrafish
(Danio rerio)
Actinopterygii cyyr1 34
  • 61.84 (n)
CYYR1 35
  • 44 (a)
OneToOne
Species where no ortholog for CYYR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYYR1 Gene

ENSEMBL:
Gene Tree for CYYR1 (if available)
TreeFam:
Gene Tree for CYYR1 (if available)

Paralogs for CYYR1 Gene

No data available for Paralogs for CYYR1 Gene

Variants for CYYR1 Gene

Sequence variations from dbSNP and Humsavar for CYYR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000085472 -- 26,467,428(+) AAAAA(A/T)ATAAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000108020 -- 26,551,709(+) CTTAC(A/G)GATTA intron-variant, nc-transcript-variant
rs1000124863 -- 26,506,077(+) TCTCA(A/G)TAGGC intron-variant
rs1000139607 -- 26,466,961(+) TAATA(C/T)AGGTA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000149669 -- 26,508,316(+) TCTTG(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYYR1 Gene

Variant ID Type Subtype PubMed ID
esv3568141 CNV loss 25503493
nsv3481 CNV insertion 18451855
nsv478242 CNV novel sequence insertion 20440878
nsv587334 CNV gain 21841781
nsv587335 CNV loss 21841781
nsv587336 CNV loss 21841781

Variation tolerance for CYYR1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYYR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYYR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYYR1 Gene

Disorders for CYYR1 Gene

Relevant External Links for CYYR1

Genetic Association Database (GAD)
CYYR1
Human Genome Epidemiology (HuGE) Navigator
CYYR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYYR1

No disorders were found for CYYR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYYR1 Gene

Publications for CYYR1 Gene

  1. Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors. (PMID: 17442112) Vitale L. … Strippoli P. (BMC Cancer 2007) 3 4 22 64
  2. Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate- specific genes. (PMID: 12062809) Vitale L. … Zannotti M. (Gene 2002) 2 3 4 64
  3. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A. … Antonarakis S.E. (Genomics 2002) 2 3 4 64
  4. Characterization of human gene locus CYYR1: a complex multi-transcript system. (PMID: 24981926) Casadei R. … Frabetti F. (Mol. Biol. Rep. 2014) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CYYR1 Gene

  • Addgene plasmids for CYYR1

Sources for CYYR1 Gene

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