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CYYR1 Gene

protein-coding   GIFtS: 48
GCID: GC21M027838

Cysteine/Tyrosine-Rich 1

(Previous name: cysteine and tyrosine-rich 1)
(Previous symbol: C21orf95)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine/Tyrosine-Rich 11 2     Cysteine And Tyrosine-Rich Protein 12
C21orf951 2 3     Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3,4b2
Cysteine And Tyrosine-Rich 11 2     Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3b2
Proline-Rich Domain-Containing Protein2 3     Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,42

External Ids:    HGNC: 162741   Entrez Gene: 1161592   Ensembl: ENSG000001662657   UniProtKB: Q96J863   

Export aliases for CYYR1 gene to outside databases

Previous GC identifers: GC21M024417 GC21M026760 GC21M013243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYYR1 Gene:
CYYR1 (cysteine/tyrosine-rich 1) is a protein-coding gene. Diseases associated with CYYR1 include neuroendocrine tumor, and hepatitis b.

Gene Wiki entry for CYYR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYYR1 gene promoter:
         Bach1   HSF1 (long)   FOXO3   FOXO3b   POU2F1   HFH-1   POU2F1a   POU2F1b   FOXO3a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYYR1 promoter sequence
   Search Chromatin IP Primers for CYYR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYYR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.2

CYYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYYR1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M027838:  view genomic region     (about GC identifiers)

Start:
27,838,528 bp from pter      End:
27,945,603 bp from pter
Size:
107,076 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CYYR1_HUMAN, Q96J86 (See protein sequence)
Recommended Name: Cysteine and tyrosine-rich protein 1 precursor  
Size: 154 amino acids; 16626 Da
Sequence caution: Sequence=BAB70764.1; Type=Erroneous initiation;
Secondary accessions: B2R845 Q53ER3 Q5JPD0 Q96NV7
Alternative splicing: 2 isoforms:  Q96J86-1   Q96J86-2   

Explore the universe of human proteins at neXtProt for CYYR1: NX_Q96J86

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_443186.1  
    ENSEMBL proteins: 
     ENSP00000299340   ENSP00000382918   ENSP00000401313  

    CYYR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CYYR1

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    LSBio Antibodies in human, mouse, rat for CYYR1

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    Cloud-Clone Corp. CLIAs for CYYR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022640 CYYR1

    Graphical View of Domain Structure for InterPro Entry Q96J86

    ProtoNet protein and cluster: Q96J86

    UniProtKB/Swiss-Prot: CYYR1_HUMAN, Q96J86
    Similarity: Belongs to the CYYR1 family


    CYYR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    CYYR1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYYR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYYR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYYR1

    miRNA
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    miRTarBase miRNAs that target CYYR1:
    hsa-mir-335-5p (MIRT019006)

    Block miRNA regulation of human, mouse, rat CYYR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYYR1 (see all 26):
    hsa-miR-30c hsa-miR-148b* hsa-miR-137 hsa-miR-30d hsa-miR-548s hsa-miR-944 hsa-miR-570 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidCYYR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CYYR1
    Predesigned siRNA for gene silencing in human, mouse, rat CYYR1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CYYR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYYR1 (NM_052954)
    Sino Biological Human cDNA Clone for CYYR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYYR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYYR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYYR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYYR1_HUMAN, Q96J86: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    CYYR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYYR1
    Interactions:

        Search GeneGlobe Interaction Network for CYYR1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CYYR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYYR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYYR1 gene: 
    NM_052954.2  

    Unigene Cluster for CYYR1:

    Cysteine/tyrosine-rich 1
    Hs.37445  [show with all ESTs]
    Unigene Representative Sequence: NM_052954
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299340(uc002ymd.3 uc011ack.2 uc002yme.3) ENST00000400043
    ENST00000435845
    miRNA
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    Block miRNA regulation of human, mouse, rat CYYR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYYR1 (see all 26):
    hsa-miR-30c hsa-miR-148b* hsa-miR-137 hsa-miR-30d hsa-miR-548s hsa-miR-944 hsa-miR-570 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidCYYR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CYYR1
    Predesigned siRNA for gene silencing in human, mouse, rat CYYR1
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    OriGene ORF clones in mouse, rat for CYYR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYYR1 (NM_052954)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYYR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYYR1
    Primer
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    OriGene qPCR primer pairs and template standards for CYYR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYYR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYYR1
      QuantiTect SYBR Green Assays in human, mouse, rat CYYR1
      QuantiFast Probe-based Assays in human, mouse, rat CYYR1

    Additional mRNA sequence: 

    AF401639.1 AK054581.1 AK223576.1 AK304124.1 AK313231.1 AL833200.1 AY061853.1 BC036761.1 

    4 DOTS entries:

    DT.308018  DT.100765198  DT.101974542  DT.100731588 

    Selected AceView cDNA sequences (see all 87):

    CA391068 AW664862 BI962525 AI433908 BM272828 BE674635 AI298919 AI143503 
    BC036761 AI184636 BE463566 BX436678 AI269294 AI122838 CR612850 AY061853 
    AI911750 BE328343 CA406765 BE046142 BU069877 AA719885 BE550821 AI800696 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CYYR1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                          -           -           -                     
    SP2:                          -           -                                 
    SP3:                          -           -           -                     
    SP4:                                      -           -                     
    SP5:                          -                                             


    ECgene alternative splicing isoforms for CYYR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYYR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATAAA
    CYYR1 Expression
    About this image


    CYYR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)
             Mature Endothelial Cells Corneal Endothelium
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Corneal Endothelium
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
    CYYR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.37445

    UniProtKB/Swiss-Prot: CYYR1_HUMAN, Q96J86
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYYR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYYR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyyr11 , 5 cysteine and tyrosine-rich protein 11, 5 82.25(n)1
    81.82(a)1
      16 (47.45 cM)5
    2244051  NM_144853.31  NP_659102.11 
     854215335 
    chicken
    (Gallus gallus)
    Aves CYYR11 cysteine/tyrosine-rich 1 75.44(n)
    78.2(a)
      770067  XM_001233378.3  XP_001233379.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57292 Xenopus laevis transcribed sequence with weak similarity more 74.16(n)    BJ622637.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyyr11 cysteine and tyrosine-rich protein 1 61.84(n)
    57.97(a)
      405818  NM_212882.1  NP_998047.1 


    ENSEMBL Gene Tree for CYYR1 (if available)
    TreeFam Gene Tree for CYYR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYYR1 (see all 75)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173937051,2
    F--27942092(+) ATTCAA/GTTGCT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1118351261,2
    C,F--27942141(+) TGTTAT/CCAAAA 1 -- int15Minor allele frequency- C:0.12NA CSA WA EA 362
    rs72775241,2
    C,F,A,H--27942187(+) AATGTT/AGTAGC 1 -- int19Minor allele frequency- A:0.21NS EA NA WA CSA 544
    rs731808301,2
    C,F--27942304(+) ACCCAA/TAAGGG 1 -- int10--------
    rs99899341,2
    C,F--27942529(+) TCTAAT/GGTCCA 1 -- int15Minor allele frequency- G:0.45NA WA CSA 126
    rs1486899911,2
    --27942619(+) CCCCAA/CCTCAC 1 -- int10--------
    rs767633931,2
    C,F--27942667(+) AATGCG/TCAGAA 1 -- int13Minor allele frequency- T:0.03NA CSA 134
    rs356041281,2
    C,F--27942705(+) ACTTGC/GTTAGA 1 -- int14Minor allele frequency- G:0.03NA 126
    rs81286891,2
    C,F,A,H--27942873(+) TTCCAA/GAAGTA 1 -- int17Minor allele frequency- G:0.21NS EA WA CSA 540
    rs1146871831,2
    F--27942989(+) ATTATG/AAGCAG 1 -- int11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for CYYR1 (27838528 - 27945603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYYR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3481CNV Insertion18451855
    nsv913660CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYYR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYYR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for CYYR1:    
    About MalaCards
    neuroendocrine tumor    hepatitis b    hepatocellular carcinoma    hepatitis
    asthma    neuroblastoma    endotheliitis


    CYYR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYYR1
    Human Genome Epidemiology (HuGE) Navigator: CYYR1 (1 document)

    Export disorders for CYYR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYYR1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CYYR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nineteen additional unpredicted transcripts from human chromosome 21. (PubMed id 12036297)1, 2, 3 Reymond A.... Antonarakis S.E. (Genomics 2002)
    2. Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate- specific genes. (PubMed id 12062809)1, 2, 3 Vitale L.... Zannotti M. (Gene 2002)
    3. Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors. (PubMed id 17442112)1, 2, 9 Vitale L....Strippoli P. (BMC Cancer 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    7. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (Am. J. Respir. Crit. Care Med. 2012)
    8. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. (PubMed id 18463370)4 Maris J.M....Hakonarson H. (N. Engl. J. Med. 2008)
    9. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116159 HGNC: 16274 AceView: CYYR1 Ensembl:ENSG00000166265 euGenes: HUgn116159
    ECgene: CYYR1 H-InvDB: CYYR1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYYR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYYR1 gene:
    Search GeneIP for patents involving CYYR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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