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Aliases for CYYR1 Gene

Aliases for CYYR1 Gene

  • Cysteine And Tyrosine Rich 1 2 3
  • Cysteine/Tyrosine-Rich 1 2 3 5
  • Proline-Rich Domain-Containing Protein 3 4
  • C21orf95 3 4
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,2bis,3,4 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3,4b 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,3b 3
  • Cysteine And Tyrosine-Rich Protein 1 Isoform 1,2,4 3
  • Cysteine And Tyrosine-Rich 1 3

External Ids for CYYR1 Gene

Previous HGNC Symbols for CYYR1 Gene

  • C21orf95

Previous GeneCards Identifiers for CYYR1 Gene

  • GC21M024417
  • GC21M026760
  • GC21M027838
  • GC21M013243

Summaries for CYYR1 Gene

GeneCards Summary for CYYR1 Gene

CYYR1 (Cysteine And Tyrosine Rich 1) is a Protein Coding gene.

Gene Wiki entry for CYYR1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYYR1 Gene

Genomics for CYYR1 Gene

Regulatory Elements for CYYR1 Gene

Promoters for CYYR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYYR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYYR1 Gene

26,466,209 bp from pter
26,573,284 bp from pter
107,076 bases
Minus strand

Genomic View for CYYR1 Gene

Genes around CYYR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYYR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYYR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYYR1 Gene

Proteins for CYYR1 Gene

  • Protein details for CYYR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine and tyrosine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • A0A059TD09
    • A8MTU9
    • B2R845
    • Q53ER3
    • Q5JPD0
    • Q96NV7
    • R9QAJ4
    • W8CQB3

    Protein attributes for CYYR1 Gene

    154 amino acids
    Molecular mass:
    16626 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYYR1 Gene

neXtProt entry for CYYR1 Gene

Proteomics data for CYYR1 Gene at MOPED

Post-translational modifications for CYYR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYYR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYYR1 Gene

Domains & Families for CYYR1 Gene

Protein Domains for CYYR1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CYYR1 family.
  • Belongs to the CYYR1 family.
genes like me logo Genes that share domains with CYYR1: view

No data available for Gene Families for CYYR1 Gene

Function for CYYR1 Gene

genes like me logo Genes that share phenotypes with CYYR1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYYR1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYYR1 Gene

Localization for CYYR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYYR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CYYR1 Gene COMPARTMENTS Subcellular localization image for CYYR1 gene
Compartment Confidence
extracellular 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for CYYR1 Gene

Pathways & Interactions for CYYR1 Gene

SuperPathways for CYYR1 Gene

No Data Available

Interacting Proteins for CYYR1 Gene

Gene Ontology (GO) - Biological Process for CYYR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CYYR1 Gene

Drugs & Compounds for CYYR1 Gene

No Compound Related Data Available

Transcripts for CYYR1 Gene

Unigene Clusters for CYYR1 Gene

Cysteine/tyrosine-rich 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYYR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for CYYR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYYR1 Gene

mRNA expression in normal human tissues for CYYR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CYYR1 Gene Hs.37445

mRNA Expression by UniProt/SwissProt for CYYR1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CYYR1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CYYR1 Gene

Orthologs for CYYR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYYR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CYYR1 35
  • 87.01 (n)
  • 87.66 (a)
CYYR1 36
  • 78 (a)
(Mus musculus)
Mammalia Cyyr1 35
  • 82.25 (n)
  • 81.82 (a)
Cyyr1 16
Cyyr1 36
  • 78 (a)
(Pan troglodytes)
Mammalia CYYR1 35
  • 99.57 (n)
  • 98.7 (a)
CYYR1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cyyr1 35
  • 80.3 (n)
  • 78.57 (a)
(Bos Taurus)
Mammalia CYYR1 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia CYYR1 36
  • 58 (a)
(Gallus gallus)
Aves CYYR1 35
  • 75.44 (n)
  • 78.2 (a)
CYYR1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyyr1 35
  • 68.89 (n)
  • 72.67 (a)
Str.10669 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5729 35
(Danio rerio)
Actinopterygii cyyr1 35
  • 61.84 (n)
  • 57.97 (a)
CYYR1 36
  • 44 (a)
Species with no ortholog for CYYR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYYR1 Gene

Gene Tree for CYYR1 (if available)
Gene Tree for CYYR1 (if available)

Paralogs for CYYR1 Gene

No data available for Paralogs for CYYR1 Gene

Variants for CYYR1 Gene

Sequence variations from dbSNP and Humsavar for CYYR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_044042 -
VAR_044043 -
rs222978 -- 26,571,816(+) TAGAA(A/G)GTCAG intron-variant
rs222979 -- 26,572,312(+) GAAAC(C/G)AGATG intron-variant
rs222980 -- 26,574,783(+) CAAAT(A/G)CACAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYYR1 Gene

Variant ID Type Subtype PubMed ID
nsv913660 CNV Gain 21882294
nsv3481 CNV Insertion 18451855

Variation tolerance for CYYR1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYYR1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYYR1 Gene

Disorders for CYYR1 Gene

Relevant External Links for CYYR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYYR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYYR1 Gene

Publications for CYYR1 Gene

  1. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A. … Antonarakis S.E. (Genomics 2002) 2 3 4 67
  2. Characterization of human gene locus CYYR1: a complex multi-transcript system. (PMID: 24981926) Casadei R. … Frabetti F. (Mol. Biol. Rep. 2014) 2 3
  3. Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors. (PMID: 17442112) Vitale L. … Strippoli P. (BMC Cancer 2007) 3 23
  4. Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate- specific genes. (PMID: 12062809) Vitale L. … Zannotti M. (Gene 2002) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CYYR1 Gene

Sources for CYYR1 Gene

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