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Aliases for CYTL1 Gene

Aliases for CYTL1 Gene

  • Cytokine Like 1 2 3 5
  • Cytokine-Like 1 2 3
  • C4orf4 3 4
  • Cytokine-Like Protein C17 3
  • Protein C17 4
  • C17 3

External Ids for CYTL1 Gene

Previous GeneCards Identifiers for CYTL1 Gene

  • GC04M005135

Summaries for CYTL1 Gene

Entrez Gene Summary for CYTL1 Gene

  • C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CYTL1 Gene

CYTL1 (Cytokine Like 1) is a Protein Coding gene. GO annotations related to this gene include receptor binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTL1 Gene

Genomics for CYTL1 Gene

Regulatory Elements for CYTL1 Gene

Promoters for CYTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYTL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYTL1 Gene

Chromosome:
4
Start:
5,014,586 bp from pter
End:
5,019,472 bp from pter
Size:
4,887 bases
Orientation:
Minus strand

Genomic View for CYTL1 Gene

Genes around CYTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTL1 Gene

Proteins for CYTL1 Gene

  • Protein details for CYTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR1-CYTL1_HUMAN
    Recommended name:
    Cytokine-like protein 1
    Protein Accession:
    Q9NRR1

    Protein attributes for CYTL1 Gene

    Size:
    136 amino acids
    Molecular mass:
    15577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYTL1 Gene

Proteomics data for CYTL1 Gene at MOPED

Post-translational modifications for CYTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYTL1 Gene

Domains & Families for CYTL1 Gene

Protein Domains for CYTL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYTL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CYTL1 Gene

Function for CYTL1 Gene

genes like me logo Genes that share phenotypes with CYTL1: view

Animal Models for CYTL1 Gene

MGI Knock Outs for CYTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYTL1

miRNA for CYTL1 Gene

miRTarBase miRNAs that target CYTL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYTL1 Gene

Localization for CYTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYTL1 Gene COMPARTMENTS Subcellular localization image for CYTL1 gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYTL1 Gene

Pathways & Interactions for CYTL1 Gene

SuperPathways for CYTL1 Gene

No Data Available

Interacting Proteins for CYTL1 Gene

Gene Ontology (GO) - Biological Process for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEA --
GO:0007165 signal transduction TAS 10857752
GO:0048839 inner ear development IEA --
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process IEA --
GO:1990079 cartilage homeostasis IEA --
genes like me logo Genes that share ontologies with CYTL1: view

No data available for Pathways by source and SIGNOR curated interactions for CYTL1 Gene

Drugs & Compounds for CYTL1 Gene

No Compound Related Data Available

Transcripts for CYTL1 Gene

mRNA/cDNA for CYTL1 Gene

Unigene Clusters for CYTL1 Gene

Cytokine-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYTL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CYTL1 Gene

GeneLoc Exon Structure for
CYTL1
ECgene alternative splicing isoforms for
CYTL1

Expression for CYTL1 Gene

mRNA expression in normal human tissues for CYTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTL1 Gene

This gene is overexpressed in Artery - Aorta (x22.6).

Protein differential expression in normal tissues from HIPED for CYTL1 Gene

This gene is overexpressed in Amniocyte (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYTL1 Gene



SOURCE GeneReport for Unigene cluster for CYTL1 Gene Hs.13872

mRNA Expression by UniProt/SwissProt for CYTL1 Gene

Q9NRR1-CYTL1_HUMAN
Tissue specificity: Specifically expressed in CD34+ hematopoietic cells.
genes like me logo Genes that share expression patterns with CYTL1: view

Protein tissue co-expression partners for CYTL1 Gene

Primer Products

In Situ Assay Products

Orthologs for CYTL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTL1 36
  • 99 (a)
OneToOne
CYTL1 35
  • 98.53 (n)
  • 98.53 (a)
cow
(Bos Taurus)
Mammalia CYTL1 36
  • 79 (a)
OneToOne
CYTL1 35
  • 84.02 (n)
  • 83.47 (a)
dog
(Canis familiaris)
Mammalia CYTL1 35
  • 84.97 (n)
  • 84.43 (a)
CYTL1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cytl1 16
Cytl1 36
  • 67 (a)
OneToOne
Cytl1 35
  • 76.99 (n)
  • 76.11 (a)
oppossum
(Monodelphis domestica)
Mammalia CYTL1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYTL1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cytl1 35
  • 77.1 (n)
  • 75.65 (a)
chicken
(Gallus gallus)
Aves CYTL1 35
  • 68.89 (n)
  • 68.57 (a)
CYTL1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cytl1 35
  • 59.68 (n)
  • 55.24 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01024686.1 36
  • 25 (a)
OneToOne
Species with no ortholog for CYTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYTL1 Gene

ENSEMBL:
Gene Tree for CYTL1 (if available)
TreeFam:
Gene Tree for CYTL1 (if available)

Paralogs for CYTL1 Gene

No data available for Paralogs for CYTL1 Gene

Variants for CYTL1 Gene

Sequence variations from dbSNP and Humsavar for CYTL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_050940 -
VAR_050941 -

Structural Variations from Database of Genomic Variants (DGV) for CYTL1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347

Variation tolerance for CYTL1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYTL1 Gene

HapMap Linkage Disequilibrium report
CYTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTL1 Gene

Disorders for CYTL1 Gene

Relevant External Links for CYTL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYTL1

No disorders were found for CYTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTL1 Gene

Publications for CYTL1 Gene

  1. Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells. (PMID: 10857752) Liu X. … Cheng L. (Genomics 2000) 2 3 4 67
  2. Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (PMID: 22011669) Kwon Y.J. … Park J.H. (J Thorac Oncol 2012) 3
  3. Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells. (PMID: 22797702) Wen M. … An Y. (Int. J. Oncol. 2012) 3
  4. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. (PMID: 22613542) Chen X.D. … Deng H.W. (Chin. Med. J. 2012) 3
  5. C17 prevents inflammatory arthritis and associated joint destruction in mice. (PMID: 21799806) Chao C. … Pflanz S. (PLoS ONE 2011) 3

Products for CYTL1 Gene

Sources for CYTL1 Gene

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