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CYTIP Gene

protein-coding   GIFtS: 55
GCID: GC02M158271

Cytohesin 1 Interacting Protein

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains, binding...)
(Previous symbol: PSCDBP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytohesin 1 Interacting Protein1 2     CASP2 3
PSCDBP1 2 3 5     CYBR2 3
Cytohesin Binder And Regulator1 2 3     HE2 5
Pleckstrin Homology, Sec7 And Coiled-Coil Domains, Binding Protein1 2     B3-12
Cytohesin Binding Protein HE1 2     CYTHIP2
Cbp HE2 3     Cytohesin-1 Interacting Protein2
Cytohesin-Associated Scaffolding Protein2 3     Cytohesin-Interacting Protein2
Cytohesin-Binding Protein HE2 3     Pleckstrin Homology, Sec7 And Coiled/Coil Domains, Binding Protein2
Pleckstrin Homology Sec7 And Coiled-Coil Domains-Binding Protein2 3     

External Ids:    HGNC: 95061   Entrez Gene: 95952   Ensembl: ENSG000001151657   OMIM: 6044485   UniProtKB: O607593   
ORGUL members:         

Export aliases for CYTIP gene to outside databases

Previous GC identifers: GC02M157982 GC02M150156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYTIP Gene:
The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting
signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.
The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27
proteins and may act to sequester CYTH1 protein in the cytoplasm.(provided by RefSeq, Aug 2008)

GeneCards Summary for CYTIP Gene:
CYTIP (cytohesin 1 interacting protein) is a protein-coding gene. Diseases associated with CYTIP include marantic endocarditis, and endocarditis. An important paralog of this gene is GRASP.

UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759
Function: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function
may be to sequester CYTH1 in the cytoplasm

Gene Wiki entry for CYTIP (PSCDBP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYTIP gene promoter:
         Tal-1   AP-1   ATF-2   Pax-2   FOXD3   Evi-1   MEF-2A   Chx10   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYTIP promoter sequence
   Search Chromatin IP Primers for CYTIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYTIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q11.2

CYTIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTIP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M158271:  view genomic region     (about GC identifiers)

Start:
158,271,131 bp from pter      End:
158,345,473 bp from pter
Size:
74,343 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759 (See protein sequence)
Recommended Name: Cytohesin-interacting protein  
Size: 359 amino acids; 40010 Da
Subunit: Interacts with CYTH1 and SNX27
Sequence caution: Sequence=AAA16575.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CYTIP:
2Z17 (3D)    
Secondary accessions: Q15630 Q8NE32

Explore the universe of human proteins at neXtProt for CYTIP: NX_O60759

Explore proteomics data for CYTIP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYTIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004279.3  
    ENSEMBL proteins: 
     ENSP00000264192   ENSP00000394308   ENSP00000407205   ENSP00000402771   ENSP00000402155  
     ENSP00000440801  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O60759

    ProtoNet protein and cluster: O60759

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759
    Similarity: Contains 1 PDZ (DHR) domain


    CYTIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYTIP_HUMAN, O60759
    Function: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function
    may be to sequester CYTH1 in the cytoplasm
    Induction: By TNF and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11867758
         
    CYTIP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CYTIP:
     Decreased cell number, increas  Decreased viability of wild-ty 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cytip):
     cellular  hematopoietic system  immune system  tumorigenesis 

    CYTIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cytiptm1Tes for CYTIP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYTIP
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYTIP

    miRNA
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    miRTarBase miRNAs that target CYTIP:
    hsa-mir-335-5p (MIRT018497), hsa-mir-26b-5p (MIRT029853)

    Block miRNA regulation of human, mouse, rat CYTIP using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CYTIP:
    hsa-miR-548m hsa-miR-223 hsa-miR-3658 hsa-miR-1260b hsa-miR-3653 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidCYTIP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYTIP_HUMAN, O60759: Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IEA--
    GO:0005938cell cortex IDA12606567

    CYTIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYTIP
    Interactions:

        GeneGlobe Interaction Network for CYTIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CYTIP (O607591, 3 ENSP000002641924) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYTH1Q154381, 3, ENSP000003543984EBI-997814,EBI-997830 I2D: score=4 STRING: ENSP00000354398
    CYTH2Q994183, ENSP000004082364I2D: score=1 STRING: ENSP00000408236
    CYTH3O437393, ENSP000002970444I2D: score=1 STRING: ENSP00000297044
    SNX27Q96L923I2D: score=1 
    TAGLN2ENSP000003570754STRING: ENSP00000357075
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030155regulation of cell adhesion IDA12606567

    CYTIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYTIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYTIP gene: 
    NM_004288.4  

    Unigene Cluster for CYTIP:

    Cytohesin 1 interacting protein
    Hs.270  [show with all ESTs]
    Unigene Representative Sequence: NM_004288
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264192(uc002tzj.1 uc010zcl.1) ENST00000418920 ENST00000457793
    ENST00000497432 ENST00000439355 ENST00000462109 ENST00000483929 ENST00000435117
    ENST00000540637
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CYTIP:
    hsa-miR-548m hsa-miR-223 hsa-miR-3658 hsa-miR-1260b hsa-miR-3653 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidCYTIP 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for CYTIP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYTIP
      QuantiTect SYBR Green Assays in human, mouse, rat CYTIP
      QuantiFast Probe-based Assays in human, mouse, rat CYTIP

    Additional mRNA sequence: 

    AF068836.1 AK301544.1 AK312753.1 BC036449.2 L06633.1 

    11 DOTS entries:

    DT.211943  DT.101974205  DT.97839814  DT.100789963  DT.120945600  DT.120945585  DT.120945591  DT.91878031 
    DT.92432999  DT.91927900  DT.97811069 

    Selected AceView cDNA sequences (see all 159):

    AW296201 AA738356 BU429247 BQ439133 CA748619 AW954213 BE503364 AI610731 
    CR594595 BC036449 BX349317 AI719792 BF174990 BF590425 NM_004288 BQ430794 
    CR611736 BQ214574 CD369190 BG231936 AV758491 CD638698 AA909062 BG547573 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYTIP    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:        -           -           -                                       
    SP2:                    -           -                                       
    SP3:        -           -                                                   
    SP4:        -                                                               


    ECgene alternative splicing isoforms for CYTIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYTIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYTIP Expression
    About this image


    CYTIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CYTIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYTIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270

    UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759
    Tissue specificity: Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYTIP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cytip1 , 5 cytohesin 1 interacting protein1, 5 82.77(n)1
    81.56(a)1
      2 (33.05 cM)5
    2279291  NM_139200.41  NP_631939.11 
     581291375 
    chicken
    (Gallus gallus)
    Aves CYTIP1 cytohesin 1 interacting protein 65(n)
    61.95(a)
      429052  XM_426609.3  XP_426609.3 
    lizard
    (Anolis carolinensis)
    Reptilia CYTIP6
    cytohesin 1 interacting protein
    48(a)
    1 ↔ 1
    GL343254.1(399429-429767)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cytip1 cytohesin 1 interacting protein 60.25(n)
    51.42(a)
      100487714  XM_002933271.1  XP_002933317.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005370361 cytohesin-interacting protein-like 53.5(n)
    49.64(a)
      100537036  XM_003199175.2  XP_003199223.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66196
    --
    7(a)
    1 → many
    3L(6069822-6074633)
    worm
    (Caenorhabditis elegans)
    Secernentea gras-16
    Protein GRAS-1 (gras-1) mRNA, complete cds
    17(a)
    1 → many
    I(7835814-7836968) WBGene00009272


    ENSEMBL Gene Tree for CYTIP (if available)
    TreeFam Gene Tree for CYTIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYTIP gene
    GRASP2  
    2 SIMAP similar genes for CYTIP using alignment to 6 protein entries:     CYTIP_HUMAN (see all proteins):
    ARHGAP23    GRASP

    CYTIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYTIP (see all 666)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58356661,2
    C--150156626(+) CGCAC-/AG    
       
    /AGAG
    agaga
    1 -- ds50010--------
    rs1471064931,2
    --158270856(+) TCATAG/TGAGTG 1 -- ds50010--------
    rs1986881,2
    C,F,O,A,H--158270960(+) TTCTCG/ATCTTA 1 -- ds500133Minor allele frequency- A:0.28NS EA NA WA CSA 3268
    rs30722041,2
    C--158271094(+) AGAGA-/AG/AGA
    G
    /GA/GAGA
    ACTTA
    1 -- ds50010--------
    rs168417061,2
    C,F,H--158271239(+) GATATT/GAAATA 1 -- ut3113Minor allele frequency- G:0.06NA NS EA 1512
    rs1817615811,2
    --158271283(+) TGATAC/TTAACA 1 -- ut310--------
    rs1868785881,2
    --158271331(+) TTAGAA/CTATAA 1 -- ut310--------
    rs1385266691,2
    C--158271350(+) GTGAGA/CAGTAA 1 -- ut310--------
    rs1919548861,2
    --158271450(+) GATTCA/GGAGAG 1 -- ut310--------
    rs2679921,2
    C,F,A,H--158271512(-) ATGTCA/GTGTTT 1 -- ut31112Minor allele frequency- C:0.00EA NA NS PA EU CA WA CSA 6704

    HapMap Linkage Disequilibrium report for CYTIP (158271131 - 158345473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CYTIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272072CNV Insertion20981092
    esv274629CNV Insertion20981092
    nsv834432CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604448    OMIM disorders: --

    6 diseases for CYTIP:    
    About MalaCards
    marantic endocarditis    endocarditis    hemiplegia    lyme disease
    herpes simplex    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for CYTIP:
    Lyme disease

    CYTIP for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYTIP
    Human Genome Epidemiology (HuGE) Navigator: CYTIP (1 document)

    Export disorders for CYTIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYTIP gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CYTIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PubMed id 11867758)1, 2, 3, 9 Tang P.... Gadina M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PubMed id 17577583)1, 2, 9 MacNeil A.J.... Pohajdak B. (Biochem. Biophys. Res. Commun. 2007)
    3. Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping. (PubMed id 10343115)1, 3, 9 Kim H.S. (Cytogenet. Cell Genet. 1999)
    4. Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. (PubMed id 21562043)1, 3 Theodoridis A.A....Steinkasserer A. (Blood 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. (PubMed id 20530790)1, 3 Balkow S....Laschinger M. (Blood 2010)
    7. Cybr, CYTIP or CASP: an attempt to pinpoint a molecule's functions and names. (PubMed id 18926288)1, 3 Heufler C....Hofer S. (Immunobiology 2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. (PubMed id 12606567)1, 2 Boehm T.... Kolanus W. (EMBO J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9595 HGNC: 9506 AceView: PSCDBP Ensembl:ENSG00000115165 euGenes: HUgn9595
    ECgene: CYTIP H-InvDB: CYTIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYTIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYTIP gene:
    Search GeneIP for patents involving CYTIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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