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Aliases for CYTIP Gene

Aliases for CYTIP Gene

  • Cytohesin 1 Interacting Protein 2 3 5
  • Cytohesin Binder And Regulator 2 3 4
  • Pleckstrin Homology Sec7 And Coiled-Coil Domains-Binding Protein 3 4
  • Cytohesin-Associated Scaffolding Protein 3 4
  • Cytohesin Binding Protein HE 2 3
  • Cytohesin-Binding Protein HE 3 4
  • Cbp HE 3 4
  • PSCDBP 3 4
  • CASP 3 4
  • CYBR 3 4
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains, Binding Protein 2
  • Pleckstrin Homology, Sec7 And Coiled/Coil Domains, Binding Protein 3
  • Cytohesin-Interacting Protein 3
  • CYTHIP 3
  • B3-1 3
  • HE 3

External Ids for CYTIP Gene

Previous HGNC Symbols for CYTIP Gene

  • PSCDBP

Previous GeneCards Identifiers for CYTIP Gene

  • GC02M157982
  • GC02M158271
  • GC02M150156

Summaries for CYTIP Gene

Entrez Gene Summary for CYTIP Gene

  • The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]

GeneCards Summary for CYTIP Gene

CYTIP (Cytohesin 1 Interacting Protein) is a Protein Coding gene. An important paralog of this gene is GRASP.

UniProtKB/Swiss-Prot for CYTIP Gene

  • By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

Gene Wiki entry for CYTIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTIP Gene

Genomics for CYTIP Gene

Regulatory Elements for CYTIP Gene

Enhancers for CYTIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CYTIP on UCSC Golden Path with GeneCards custom track

Genomic Location for CYTIP Gene

Chromosome:
2
Start:
157,414,619 bp from pter
End:
157,488,961 bp from pter
Size:
74,343 bases
Orientation:
Minus strand

Genomic View for CYTIP Gene

Genes around CYTIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTIP Gene

Proteins for CYTIP Gene

  • Protein details for CYTIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60759-CYTIP_HUMAN
    Recommended name:
    Cytohesin-interacting protein
    Protein Accession:
    O60759
    Secondary Accessions:
    • B4DWH9
    • Q15630
    • Q8NE32

    Protein attributes for CYTIP Gene

    Size:
    359 amino acids
    Molecular mass:
    40010 Da
    Quaternary structure:
    • Interacts with CYTH1 and SNX27.
    SequenceCaution:
    • Sequence=AAA16575.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CYTIP Gene

    Alternative splice isoforms for CYTIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYTIP Gene

Post-translational modifications for CYTIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTIP Gene

No data available for DME Specific Peptides for CYTIP Gene

Domains & Families for CYTIP Gene

Gene Families for CYTIP Gene

Protein Domains for CYTIP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60759

UniProtKB/Swiss-Prot:

CYTIP_HUMAN :
  • Contains 1 PDZ (DHR) domain.
Domain:
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with CYTIP: view

Function for CYTIP Gene

Molecular function for CYTIP Gene

UniProtKB/Swiss-Prot Function:
By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
UniProtKB/Swiss-Prot Induction:
By TNF and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for CYTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11867758
genes like me logo Genes that share ontologies with CYTIP: view
genes like me logo Genes that share phenotypes with CYTIP: view

Animal Models for CYTIP Gene

MGI Knock Outs for CYTIP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYTIP Gene

Localization for CYTIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTIP Gene

Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYTIP Gene COMPARTMENTS Subcellular localization image for CYTIP gene
Compartment Confidence
endosome 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CYTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12606567
GO:0005769 early endosome IEA --
GO:0005938 cell cortex IDA 12606567
genes like me logo Genes that share ontologies with CYTIP: view

Pathways & Interactions for CYTIP Gene

SuperPathways for CYTIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030155 regulation of cell adhesion IDA 12606567
genes like me logo Genes that share ontologies with CYTIP: view

No data available for Pathways by source and SIGNOR curated interactions for CYTIP Gene

Drugs & Compounds for CYTIP Gene

No Compound Related Data Available

Transcripts for CYTIP Gene

Unigene Clusters for CYTIP Gene

Cytohesin 1 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYTIP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for CYTIP Gene

GeneLoc Exon Structure for
CYTIP
ECgene alternative splicing isoforms for
CYTIP

Expression for CYTIP Gene

mRNA expression in normal human tissues for CYTIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTIP Gene

This gene is overexpressed in Whole Blood (x30.2).

Protein differential expression in normal tissues from HIPED for CYTIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.1) and CD8 Tcells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYTIP Gene



Protein tissue co-expression partners for CYTIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYTIP Gene:

CYTIP

SOURCE GeneReport for Unigene cluster for CYTIP Gene:

Hs.270

mRNA Expression by UniProt/SwissProt for CYTIP Gene:

O60759-CYTIP_HUMAN
Tissue specificity: Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow.
genes like me logo Genes that share expression patterns with CYTIP: view

Primer Products

Orthologs for CYTIP Gene

This gene was present in the common ancestor of animals.

Orthologs for CYTIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYTIP 34
  • 86.55 (n)
  • 85.15 (a)
CYTIP 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYTIP 34
  • 87.23 (n)
  • 86.76 (a)
CYTIP 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cytip 34
  • 82.77 (n)
  • 81.56 (a)
Cytip 16
Cytip 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYTIP 34
  • 99.54 (n)
  • 100 (a)
CYTIP 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cytip 34
  • 82.68 (n)
  • 82.12 (a)
oppossum
(Monodelphis domestica)
Mammalia CYTIP 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYTIP 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYTIP 34
  • 65 (n)
  • 61.95 (a)
CYTIP 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYTIP 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cytip 34
  • 60.25 (n)
  • 51.42 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537036 34
  • 53.5 (n)
  • 49.64 (a)
CABZ01075242.1 35
  • 39 (a)
ManyToMany
si:dkey-276j7.2 35
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6619 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gras-1 35
  • 17 (a)
OneToMany
Species where no ortholog for CYTIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYTIP Gene

ENSEMBL:
Gene Tree for CYTIP (if available)
TreeFam:
Gene Tree for CYTIP (if available)

Paralogs for CYTIP Gene

Paralogs for CYTIP Gene

(2) SIMAP similar genes for CYTIP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CYTIP: view

Variants for CYTIP Gene

Sequence variations from dbSNP and Humsavar for CYTIP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1042038 - 157,443,912(-) CGATG(A/G)ACGAT reference, missense
rs2229345 - 157,434,402(-) AGAAG(C/G)AGGAT reference, missense
VAR_064706 -
rs1380249 -- 157,439,287(-) TGTCA(C/G)AGAAT intron-variant
rs15353 -- 157,415,379(-) TTTTC(A/T)AGATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYTIP Gene

Variant ID Type Subtype PubMed ID
esv3893503 CNV gain 25118596
nsv1011505 CNV gain 25217958
nsv1160876 CNV duplication 26073780
nsv834432 CNV gain 17160897
nsv955270 CNV duplication 24416366

Variation tolerance for CYTIP Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYTIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYTIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTIP Gene

Disorders for CYTIP Gene

Relevant External Links for CYTIP

Genetic Association Database (GAD)
CYTIP
Human Genome Epidemiology (HuGE) Navigator
CYTIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYTIP

No disorders were found for CYTIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTIP Gene

Publications for CYTIP Gene

  1. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PMID: 11867758) Tang P. … Gadina M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 22 65
  2. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PMID: 17577583) MacNeil A.J. … Pohajdak B. (Biochem. Biophys. Res. Commun. 2007) 3 4 22 65
  3. Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping. (PMID: 10343115) Kim H.S. (Cytogenet. Cell Genet. 1999) 2 3 22 65
  4. Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. (PMID: 21562043) Theodoridis A.A. … Steinkasserer A. (Blood 2011) 2 3 65
  5. LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. (PMID: 20530790) Balkow S. … Laschinger M. (Blood 2010) 2 3 65

Products for CYTIP Gene

Sources for CYTIP Gene

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