Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYTIP Gene

protein-coding   GIFtS: 51
GCID: GC02M158271

cytohesin 1 interacting protein

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains, binding...)
(Previous symbol: PSCDBP)
 Explore 6 diseases affiliated with
CYTIP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYTIP    

Aliases
for CYTIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytohesin 1 Interacting Protein1 2     Cytohesin Binder And Regulator2 3
PSCDBP1 2 3 5     Cytohesin-Associated Scaffolding Protein2 3
CASP1 2 3     Cytohesin-Binding Protein HE2 3
CYBR1 2 3     Pleckstrin Homology Sec7 And Coiled-Coil Domains-Binding Protein2 3
HE1 2 5     Cytohesin Binding Protein HE2
B3-11 2     Cytohesin-1 Interacting Protein2
CYTHIP1 2     Cytohesin-Interacting Protein2
Pleckstrin Homology, Sec7 And Coiled-Coil Domains, Binding Protein1 2     Pleckstrin Homology, Sec7 And Coiled/Coil Domains, Binding Protein2
Cbp HE2 3     

External Ids:    HGNC: 95061   Entrez Gene: 95952   Ensembl: ENSG000001151657   OMIM: 6044485   UniProtKB: O607593   

Export aliases for CYTIP gene to outside databases

Previous GC identifers: GC02M157982 GC02M150156


Summaries
for CYTIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYTIP:
The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal,
but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded
protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may
act to sequester CYTH1 protein in the cytoplasm.(provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759
Function: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may
be to sequester CYTH1 in the cytoplasm

Gene Wiki entry for CYTIP (PSCDBP)


Genomic Views
for CYTIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYTIP gene promoter:
         Tal-1   AP-1   ATF-2   Pax-2   FOXD3   Evi-1   MEF-2A   Chx10   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYTIP promoter sequence
   Search SABiosciences Chromatin IP Primers for CYTIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q11.2

CYTIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTIP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M158271:  view genomic region     (about GC identifiers)

Start:
 158,271,131 bp from pter      End:
 158,345,473 bp from pter
Size:
 74,343 bases      Orientation:
 minus strand

Proteins
for CYTIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759 (See protein sequence)
Recommended Name: Cytohesin-interacting protein  
Size: 359 amino acids; 40010 Da
Subunit: Interacts with CYTH1 and SNX27
Subcellular location: Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27
Sequence caution: Sequence=AAA16575.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CYTIP:
2Z17 (3D)    
Secondary accessions: Q15630 Q8NE32

Explore the universe of human proteins at neXtProt for CYTIP: NX_O60759

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60759

    • CYTIP Protein expression data from MOPED and PaxDb:    About this image 
    CYTIP Protein Expression
    REFSEQ proteins: NP_004279.3  
    ENSEMBL proteins: 
     ENSP00000264192   ENSP00000394308   ENSP00000407205   ENSP00000402771   ENSP00000402155  
     ENSP00000440801  

    Human Recombinant Protein Products for CYTIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CYTIP
    OriGene Custom Protein Services for CYTIP 
    GenScript Custom Purified and Recombinant Proteins Services for CYTIP
    Novus Biologicals CYTIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CYTIP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IEA--
    GO:0005938cell cortex IDA12606567

    CYTIP for ontologies           About GeneDecksing



    CYTIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): CYTIP
    OriGene Custom Antibody Services for CYTIP 
    GenScript Custom Superior Antibodies Services for CYTIP
    Novus Biologicals CYTIP Antibodies
    Abcam antibodies for CYTIP 
    Uscn Antibodies for CYTIP
    ThermoFisher Antibodies for CYTIP

    Assay Products for CYTIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYTIP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CYTIP

    Protein Domains /
    Families
    for CYTIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYTIP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O60759

    ProtoNet protein and cluster: O60759

    1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for CYTIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYTIP_HUMAN, O60759
    Function: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may
    be to sequester CYTH1 in the cytoplasm
    Induction: By TNF and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11867758
         
    CYTIP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CYTIP:
     Decreased cell number, increas  Decreased viability of wild-ty 

         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cytip):
     cellular  hematopoietic system  immune system  tumorigenesis 

    CYTIP for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Cytiptm1Tes for CYTIP
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYTIP 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CYTIP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTIP
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTIP:
    hsa-miR-548m hsa-miR-223 hsa-miR-3658 hsa-miR-1260b hsa-miR-3653 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmid: CYTIP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTIP (see all 4)
    OriGene shRNA RFP: CYTIP
    OriGene siRNA: CYTIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTIP
    Sirion Biotech Custom design and validation of potent shRNA sequences against CYTIP 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CYTIP
    Sirion Biotech Customized adenovirus for overexpression of CYTIP 
    Sirion Biotech Customized adenovirus for potent knockdown of CYTIP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTIP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CYTIP (NM_004288)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTIP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CYTIP
    Search LifeMap BioReagents cell lines for CYTIP
    Sirion Biotech Customized stable knockdown cell line services for CYTIP 
    Sirion Biotech Customized inducible knockdown cell line services for CYTIP
    Sirion Biotech Customized stable overexpressing cell line services for CYTIP
    Sirion Biotech Customized inducible overexpressing cell line services for CYTIP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTIP


    Pathways & Interactions
    for CYTIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYTIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for CYTIP (O607591, 3 ENSP000002641924) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYTH1Q154381, 3, ENSP000003543984EBI-2803304,EBI-997830 I2D: score=4 STRING: ENSP00000354398
    CYTH2Q994183, ENSP000004082364I2D: score=1 STRING: ENSP00000408236
    CYTH3O437393, ENSP000002970444I2D: score=1 STRING: ENSP00000297044
    SNX27Q96L923I2D: score=1 
    TAGLN2ENSP000003570754STRING: ENSP00000357075
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030155regulation of cell adhesion IDA12606567

    CYTIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYTIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYTIP
    Search CenterWatch for drugs/clinical trials and news about CYTIP 

    Transcripts
    for CYTIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYTIP gene: 
    NM_004288.4  

    Unigene Cluster for CYTIP:

    Cytohesin 1 interacting protein
    Hs.270  [show with all ESTs]
    Unigene Representative Sequence: NM_004288
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264192(uc002tzj.1 uc010zcl.1) ENST00000418920 ENST00000457793
    ENST00000497432 ENST00000439355 ENST00000462109 ENST00000483929 ENST00000435117
    ENST00000540637

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CYTIP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTIP
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTIP:
    hsa-miR-548m hsa-miR-223 hsa-miR-3658 hsa-miR-1260b hsa-miR-3653 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmid: CYTIP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTIP (see all 4)
    OriGene shRNA RFP: CYTIP
    OriGene siRNA: CYTIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTIP
    Sirion Biotech Custom design and validation of potent shRNA sequences against CYTIP 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTIP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CYTIP (NM_004288)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTIP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYTIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTIP

    Additional cDNA sequence: 

    AF068836.1 AK301544.1 AK312753.1 BC036449.2 L06633.1 

    11 DOTS entries:

    DT.211943  DT.101974205  DT.97839814  DT.100789963  DT.120945600  DT.120945585  DT.120945591  DT.91878031 
    DT.92432999  DT.91927900  DT.97811069 

    24/159 AceView cDNA sequences (see all 159):

    AA738356 BF590425 BC036449 BQ430794 BF174990 BQ214574 AI610731 AW954213 
    CR611736 BU429247 BE503364 CD369190 BQ439133 AI719792 CA748619 CR594595 
    NM_004288 BX349317 AW296201 AA211809 AW117608 AI343865 BQ003668 AI872539 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYTIP    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:        -           -           -                                       
    SP2:                    -           -                                       
    SP3:        -           -                                                   
    SP4:        -                                                               


    ECgene alternative splicing isoforms for CYTIP

    Expression
    for CYTIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYTIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    CYTIP Expression
    About this image

    CYTIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CYTIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYTIP

    SOURCE GeneReport for Unigene cluster: Hs.270

    UniProtKB/Swiss-Prot: CYTIP_HUMAN, O60759
    Tissue specificity: Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow

        SABiosciences Custom PCR Arrays for CYTIP
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYTIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTIP
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTIP

    Orthologs
    for CYTIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CYTIP gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CYTIP1 cytohesin 1 interacting protein 64.7(n)
    61.65(a)    		   429052  XM_426609.2  XP_426609.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CYTIP6
    		 --
    		 53(a)
    		 1 ↔ 1
    		 GL343254.1(408298-425290)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005370361 cytohesin-interacting protein-like 54.6(n)
    50.9(a)    		   100537036  XM_003199175.1  XP_003199223.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG66196
    		 --
    		 8(a)
    		 1 → many
    		 3L(6069822-6074633)


    ENSEMBL Gene Tree for CYTIP (if available)
    TreeFam Gene Tree for CYTIP (if available) 

    Paralogs
    for CYTIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYTIP gene
    GRASP2  
    2 SIMAP similar genes for CYTIP using alignment to 6 protein entries:     CYTIP_HUMAN (see all proteins):
    ARHGAP23    GRASP

    CYTIP for paralogs           About GeneDecksing



    Genomic Variants
    for CYTIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/553 NCBI SNPs in CYTIP are shown (see all 553)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1471064931,2
    		--158270856(+) TCATAG/TGAGTG 1 -- ds50010--------
    rs1986881,2
    		C,F,O,A,H--158270960(+) TTCTCG/ATCTTA 1 -- ds500133Minor allele frequency- A:0.28NS EA NA WA CSA 3268
    rs168417061,2
    		C,F,H--158271239(+) GATATT/GAAATA 1 -- ut3113Minor allele frequency- G:0.06NA NS EA 1512
    rs1817615811,2
    		--158271283(+) TGATAC/TTAACA 1 -- ut310--------
    rs1868785881,2
    		--158271331(+) TTAGAA/CTATAA 1 -- ut310--------
    rs1385266691,2
    		--158271350(+) GTGAGA/CAGTAA 1 -- ut310--------
    rs1919548861,2
    		--158271450(+) GATTCA/GGAGAG 1 -- ut310--------
    rs2679921,2
    		C,F,A,H--158271512(-) ATGTCA/GTGTTT 1 -- ut31112Minor allele frequency- C:0.00EA NA NS PA EU CA WA CSA 6704
    rs1811289771,2
    		--158271537(+) TTTAGA/TCTGTC 1 -- ut310--------
    rs1159351041,2
    		F--158271546(+) TCTATA/TAAAAT 1 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for CYTIP (158271131 - 158345473 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYTIP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYTIP
    DNA2.0 Custom Variant and Variant Library Synthesis for CYTIP

    Disorders / Diseases
    for CYTIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYTIP for disorders           About GeneDecksing

    OMIM gene information: 604448    OMIM disorders: --

    6 diseases for CYTIP:    About MalaCards
    marantic endocarditis    herpes simplex    hemiplegia    endocarditis
    lyme disease    esophagitis

    1 disease from the University of Copenhagen DISEASES database for CYTIP:
    Lyme disease
    Human Genome Epidemiology (HuGE) Navigator: CYTIP (1 document)

    Export disorders for CYTIP gene to outside databases

    Publications
    for CYTIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYTIP gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CYTIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PubMed id 11867758)1, 2, 3, 9 Tang P.... Gadina M. (2002)
    2. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PubMed id 17577583)1, 2, 9 MacNeil A.J.... Pohajdak B. (2007)
    3. Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping. (PubMed id 10343115)1, 3, 9 Kim H.S. (1999)
    4. Infection of dendritic cells with herpes simplex viru s type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and mi gration. (PubMed id 21562043)1, 3 Theodoridis A.A....Steinkasserer A. (2011)
    5. LFA-1 activity state on dendritic cells regulates con tact duration with T cells and promotes T-cell priming. (PubMed id 20530790)1, 3 Balkow S....Laschinger M. (2010)
    6. Cybr, CYTIP or CASP: an attempt to pinpoint a molecul e's functions and names. (PubMed id 18926288)1, 3 Heufler C....Hofer S. (2008)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. (PubMed id 12606567)1, 2 Boehm T.... Kolanus W. (2003)
    10. Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein. (PubMed id 8241278)1, 2 Dixon B.... Pohajdak B. (1993)

    External Searches for CYTIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYTIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9595 HGNC: 9506 AceView: PSCDBP Ensembl:ENSG00000115165 euGenes: HUgn9595
    ECgene: CYTIP H-InvDB: CYTIP

    Other Databases showing CYTIP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYTIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYTIP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CYTIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYTIP gene:
    Search GeneIP for patents involving CYTIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CYTIP gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CYTIP   OriGene shRNA RFP for CYTIP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTIP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYTIP  
     OriGene Protein Over-expression Lysate for CYTIP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CYTIP   OriGene 3'-UTR Clone for CYTIP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTIP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTIP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYTIP   OriGene Custom Protein Services for CYTIP  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYTIP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYTIP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTIP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTIP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTIP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTIP
     GenScript Custom Purified and Recombinant Proteins Services for CYTIP GenScript cDNA clones with any tag delivered in your preferred vector for CYTIP
     GenScript Custom Assay Services for CYTIP GenScript Custom Superior Antibodies Services for CYTIP
     GenScript Custom overexpressing Cell Line Services for CYTIP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CYTIP promoter
     Search Chromatin IP Primers for CYTIP
     RT2 qPCR Primer Assay in human, mouse, rat CYTIP
     GNC Network for CYTIP
     SABiosciences Custom PCR Arrays for CYTIP
     Search Tocris compounds for CYTIP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CYTIP antibodies
     CYTIP lysates
     Antibodies for CYTIP
     See all of Abcam's Antibodies, Kits and Proteins for CYTIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CYTIP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CYTIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTIP
     SwitchGear 3'UTR luciferase reporter plasmids for CYTIP
     SwitchGear Promoter luciferase reporter plasmids for CYTIP
     ThermoFisher Antibodies for CYTIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTIP
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYTIP
    Sirion Biotech Customized:
     stable knockdown cell line services for CYTIP
     inducible knockdown cell line services for CYTIP
     design and validation of potent shRNA sequences against CYTIP
     adenovirus for potent knockdown of CYTIP
     adenovirus for overexpression of CYTIP
     stable overexpressing cell line services for CYTIP
     inducible overexpressing cell line services for CYTIP
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CYTIP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4