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Aliases for CYTH4 Gene

Aliases for CYTH4 Gene

  • Cytohesin 4 2 3
  • PSCD4 3 4 6
  • CYT4 3 4 6
  • PH, SEC7 And Coiled-Coil Domain-Containing Protein 4 3 4
  • Pleckstrin Homology, Sec7 And Coiled/Coil Domains 4 2 3
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains 4 2 3
  • Cytohesin-4 3
  • DJ63G5.1 3

External Ids for CYTH4 Gene

Previous HGNC Symbols for CYTH4 Gene

  • PSCD4

Previous GeneCards Identifiers for CYTH4 Gene

  • GC22P036008
  • GC22P037681
  • GC22P020643

Summaries for CYTH4 Gene

Entrez Gene Summary for CYTH4 Gene

  • The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008]

GeneCards Summary for CYTH4 Gene

CYTH4 (Cytohesin 4) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

UniProtKB/Swiss-Prot for CYTH4 Gene

  • Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Wiki entry for CYTH4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTH4 Gene

Genomics for CYTH4 Gene

Regulatory Elements for CYTH4 Gene

Genomic Location for CYTH4 Gene

Start:
37,282,027 bp from pter
End:
37,315,348 bp from pter
Size:
33,322 bases
Orientation:
Plus strand

Genomic View for CYTH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYTH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTH4 Gene

Proteins for CYTH4 Gene

  • Protein details for CYTH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIA0-CYH4_HUMAN
    Recommended name:
    Cytohesin-4
    Protein Accession:
    Q9UIA0
    Secondary Accessions:
    • Q5R3F9
    • Q9UGT6

    Protein attributes for CYTH4 Gene

    Size:
    394 amino acids
    Molecular mass:
    45672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYTH4 Gene

Proteomics data for CYTH4 Gene at MOPED

Post-translational modifications for CYTH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTH4 Gene

No data available for DME Specific Peptides for CYTH4 Gene

Domains for CYTH4 Gene

Gene Families for CYTH4 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for CYTH4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIA0

UniProtKB/Swiss-Prot:

CYH4_HUMAN :
  • Q9UIA0
Domain:
  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
  • Autoinhibited by its C-terminal basic region.
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
genes like me logo Genes that share domains with CYTH4: view

Function for CYTH4 Gene

Molecular function for CYTH4 Gene

UniProtKB/Swiss-Prot Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Ontology (GO) - Molecular Function for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IDA 10652308
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with CYTH4: view

Animal Model Products

miRNA for CYTH4 Gene

miRTarBase miRNAs that target CYTH4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYTH4 Gene

Localization for CYTH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTH4 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYTH4 Gene COMPARTMENTS Subcellular localization image for CYTH4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 NOT trans-Golgi network IBA --
GO:0005886 plasma membrane IDA 17398095
genes like me logo Genes that share ontologies with CYTH4: view

Pathways for CYTH4 Gene

SuperPathways for CYTH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 NOT vesicle-mediated transport IBA --
GO:0030155 regulation of cell adhesion IBA --
GO:0032012 regulation of ARF protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with CYTH4: view

No data available for Pathways by source for CYTH4 Gene

Compounds for CYTH4 Gene

(1) HMDB Compounds for CYTH4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CYTH4: view

Transcripts for CYTH4 Gene

Unigene Clusters for CYTH4 Gene

Cytohesin 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYTH4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYTH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: -
SP7: -
SP8:
SP9: -

ExUns: 15a · 15b ^ 16a · 16b · 16c
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CYTH4 Gene

GeneLoc Exon Structure for
CYTH4
ECgene alternative splicing isoforms for
CYTH4

Expression for CYTH4 Gene

mRNA expression in normal human tissues for CYTH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTH4 Gene

This gene is overexpressed in Whole Blood (32.9) and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYTH4 Gene

SOURCE GeneReport for Unigene cluster for CYTH4 Gene Hs.170944

mRNA Expression by UniProt/SwissProt for CYTH4 Gene

Q9UIA0-CYH4_HUMAN
Tissue specificity: Expressed predominantly in peripheral blood leukocytes.
genes like me logo Genes that share expressions with CYTH4: view

In Situ Assay Products

Orthologs for CYTH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYTH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTH4 35
  • 99.07 (n)
  • 99.75 (a)
CYTH4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYTH4 35
  • 89.59 (n)
  • 94.67 (a)
CYTH4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYTH4 35
  • 89.51 (n)
  • 94.67 (a)
CYTH4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyth4 35
  • 86.68 (n)
  • 92.11 (a)
Cyth4 16
Cyth4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYTH4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyth4 35
  • 86.82 (n)
  • 93.22 (a)
chicken
(Gallus gallus)
Aves CYTH4 35
  • 74.05 (n)
  • 77.61 (a)
CYTH4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYTH4 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyth4a 36
  • 62 (a)
OneToMany
cyth4b 35
  • 69.78 (n)
  • 72.21 (a)
cyth4b 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta step 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grp-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC7 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
ManyToMany
CSA.8851 36
  • 58 (a)
ManyToMany
Species with no ortholog for CYTH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYTH4 Gene

ENSEMBL:
Gene Tree for CYTH4 (if available)
TreeFam:
Gene Tree for CYTH4 (if available)

Paralogs for CYTH4 Gene

Selected SIMAP similar genes for CYTH4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CYTH4: view

Variants for CYTH4 Gene

Sequence variations from dbSNP and Humsavar for CYTH4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs15996 -- 37,315,037(-) AAGGT(C/G)TCCTC utr-variant-3-prime, nc-transcript-variant
rs727047 -- 37,281,678(+) TCAAA(A/G)GAGAA upstream-variant-2KB
rs727048 -- 37,281,851(+) TCACA(C/T)GACAT upstream-variant-2KB
rs733271 -- 37,290,072(+) AGGTA(C/G)CAATA intron-variant
rs763079 -- 37,296,933(+) TAAAA(C/G)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYTH4 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834188 CNV Loss 17160897
nsv834189 CNV Gain+Loss 17160897
nsv817992 CNV Gain 17921354
nsv834190 CNV Loss 17160897
nsv471196 CNV Loss 18288195
dgv4961n71 CNV Loss 21882294

Relevant External Links for CYTH4 Gene

HapMap Linkage Disequilibrium report
CYTH4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTH4 Gene

Disorders for CYTH4 Gene

(1) University of Copenhagen DISEASES for CYTH4 Gene

Relevant External Links for CYTH4

Genetic Association Database (GAD)
CYTH4
Human Genome Epidemiology (HuGE) Navigator
CYTH4
genes like me logo Genes that share disorders with CYTH4: view

No data available for UniProtKB/Swiss-Prot for CYTH4 Gene

Publications for CYTH4 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PMID: 10652308) Ogasawara M. … Vaughan M. (J. Biol. Chem. 2000) 3 4 23
  3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I. … Munro S. (Curr. Biol. 2007) 3 4 23
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CYTH4 Gene

Sources for CYTH4 Gene

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