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Aliases for CYTH4 Gene

Aliases for CYTH4 Gene

  • Cytohesin 4 2 3 5
  • PH, SEC7 And Coiled-Coil Domain-Containing Protein 4 3 4
  • Pleckstrin Homology, Sec7 And Coiled/Coil Domains 4 2 3
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains 4 2 3
  • PSCD4 3 4
  • CYT4 3 4
  • DJ63G5.1 3

External Ids for CYTH4 Gene

Previous HGNC Symbols for CYTH4 Gene

  • PSCD4

Previous GeneCards Identifiers for CYTH4 Gene

  • GC22P036008
  • GC22P037681
  • GC22P020643

Summaries for CYTH4 Gene

Entrez Gene Summary for CYTH4 Gene

  • This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for CYTH4 Gene

CYTH4 (Cytohesin 4) is a Protein Coding gene. Among its related pathways are Phospholipase D signaling pathway and Golgi-to-ER retrograde transport. GO annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

UniProtKB/Swiss-Prot for CYTH4 Gene

  • Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Wiki entry for CYTH4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTH4 Gene

Genomics for CYTH4 Gene

Regulatory Elements for CYTH4 Gene

Enhancers for CYTH4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYTH4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYTH4 Gene

37,282,027 bp from pter
37,315,348 bp from pter
33,322 bases
Plus strand

Genomic View for CYTH4 Gene

Genes around CYTH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTH4 Gene

Proteins for CYTH4 Gene

  • Protein details for CYTH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5R3F9
    • Q9UGT6

    Protein attributes for CYTH4 Gene

    394 amino acids
    Molecular mass:
    45672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYTH4 Gene

Proteomics data for CYTH4 Gene at MOPED

Post-translational modifications for CYTH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTH4 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for CYTH4

No data available for DME Specific Peptides for CYTH4 Gene

Domains & Families for CYTH4 Gene

Gene Families for CYTH4 Gene

Protein Domains for CYTH4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
  • Autoinhibited by its C-terminal basic region.
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
genes like me logo Genes that share domains with CYTH4: view

Function for CYTH4 Gene

Molecular function for CYTH4 Gene

UniProtKB/Swiss-Prot Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
genes like me logo Genes that share phenotypes with CYTH4: view

Animal Model Products

miRNA for CYTH4 Gene

miRTarBase miRNAs that target CYTH4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYTH4 Gene

Localization for CYTH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTH4 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CYTH4 Gene COMPARTMENTS Subcellular localization image for CYTH4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 17398095
genes like me logo Genes that share ontologies with CYTH4: view

Pathways & Interactions for CYTH4 Gene

genes like me logo Genes that share pathways with CYTH4: view

Pathways by source for CYTH4 Gene

Gene Ontology (GO) - Biological Process for CYTH4 Gene


No data available for SIGNOR curated interactions for CYTH4 Gene

Drugs & Compounds for CYTH4 Gene

(1) Drugs for CYTH4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CYTH4: view

Transcripts for CYTH4 Gene

Unigene Clusters for CYTH4 Gene

Cytohesin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYTH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: -
SP7: -
SP9: -

ExUns: 15a · 15b ^ 16a · 16b · 16c
SP2: -

Relevant External Links for CYTH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYTH4 Gene

mRNA expression in normal human tissues for CYTH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTH4 Gene

This gene is overexpressed in Whole Blood (x32.9) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for CYTH4 Gene

This gene is overexpressed in CD8 Tcells (17.3), Pancreas (9.9), Blymphocyte (9.2), Peripheral blood mononuclear cells (7.9), Monocytes (6.7), Spleen (6.3), and NK cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYTH4 Gene

SOURCE GeneReport for Unigene cluster for CYTH4 Gene Hs.170944

mRNA Expression by UniProt/SwissProt for CYTH4 Gene

Tissue specificity: Expressed predominantly in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with CYTH4: view

Protein tissue co-expression partners for CYTH4 Gene

- Elite partner

Primer Products

Orthologs for CYTH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYTH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYTH4 35
  • 89.59 (n)
  • 94.67 (a)
CYTH4 36
  • 92 (a)
(Canis familiaris)
Mammalia CYTH4 35
  • 89.51 (n)
  • 94.67 (a)
CYTH4 36
  • 95 (a)
(Mus musculus)
Mammalia Cyth4 35
  • 86.68 (n)
  • 92.11 (a)
Cyth4 16
Cyth4 36
  • 92 (a)
(Pan troglodytes)
Mammalia CYTH4 35
  • 99.07 (n)
  • 99.75 (a)
CYTH4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cyth4 35
  • 86.82 (n)
  • 93.22 (a)
(Monodelphis domestica)
Mammalia CYTH4 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 88 (a)
(Gallus gallus)
Aves CYTH4 35
  • 74.05 (n)
  • 77.61 (a)
CYTH4 36
  • 75 (a)
(Anolis carolinensis)
Reptilia CYTH4 36
  • 71 (a)
(Danio rerio)
Actinopterygii cyth4b 35
  • 69.78 (n)
  • 72.21 (a)
cyth4a 36
  • 62 (a)
cyth4b 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta step 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea grp-1 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC7 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
CSA.8851 36
  • 58 (a)
Species with no ortholog for CYTH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYTH4 Gene

Gene Tree for CYTH4 (if available)
Gene Tree for CYTH4 (if available)

Paralogs for CYTH4 Gene

genes like me logo Genes that share paralogs with CYTH4: view

Variants for CYTH4 Gene

Sequence variations from dbSNP and Humsavar for CYTH4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_051920 -
rs2267363 -- 37,281,351(+) ACATC(G/T)GCCGT upstream-variant-2KB
rs2267364 -- 37,281,363(+) ATCTC(C/T)TCCAT upstream-variant-2KB
rs7288236 -- 37,284,958(+) GGCGG(C/T)GGGGG intron-variant
rs7288504 -- 37,284,957(+) GGGCG(A/G)CGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYTH4 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834188 CNV Loss 17160897
nsv834189 CNV Gain+Loss 17160897
nsv817992 CNV Gain 17921354
nsv834190 CNV Loss 17160897
nsv471196 CNV Loss 18288195
dgv4961n71 CNV Loss 21882294

Variation tolerance for CYTH4 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 54.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYTH4 Gene

Disorders for CYTH4 Gene

Relevant External Links for CYTH4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYTH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTH4 Gene

Publications for CYTH4 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I. … Munro S. (Curr. Biol. 2007) 3 23
  3. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PMID: 10652308) Ogasawara M. … Vaughan M. (J. Biol. Chem. 2000) 3 23
  4. A primate-specific functional GTTT-repeat in the core promoter of CYTH4 is linked to bipolar disorder in human. (PMID: 25240857) Rezazadeh M. … Ohadi M. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2015) 3
  5. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3

Products for CYTH4 Gene

Sources for CYTH4 Gene