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CYTH4 Gene

protein-coding   GIFtS: 53
GCID: GC22P037681

Cytohesin 4

(Previous names: pleckstrin homology, Sec7 and coiled/coil domains 4, pleckstrin...)
(Previous symbol: PSCD4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytohesin 41 2     Pleckstrin Homology, Sec7 And Coiled/Coil Domains 41 2
PSCD41 2 3 5     PH, SEC7 And Coiled-Coil Domain-Containing Protein 42 3
CYT42 3 5     DJ63G5.12
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 41 2     cytohesin-42

External Ids:    HGNC: 95051   Entrez Gene: 271282   Ensembl: ENSG000001000557   OMIM: 6065145   UniProtKB: Q9UIA03   

Export aliases for CYTH4 gene to outside databases

Previous GC identifers: GC22P036008 GC22P020643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYTH4 Gene:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin
homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains
guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of
protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and
ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. (provided by RefSeq, Aug
2008)

GeneCards Summary for CYTH4 Gene:
CYTH4 (cytohesin 4) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through
replacement of GDP with GTP

Gene Wiki entry for CYTH4 (PSCD4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYTH4 gene promoter:
         GR   YY1   E47   HEN1   PPAR-gamma1   STAT3   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYTH4 promoter sequence
   Search Chromatin IP Primers for CYTH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYTH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3-q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q12.3-q13.1

CYTH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P037681:  view genomic region     (about GC identifiers)

Start:
37,678,068 bp from pter      End:
37,711,389 bp from pter
Size:
33,322 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0 (See protein sequence)
Recommended Name: Cytohesin-4  
Size: 394 amino acids; 45672 Da
Secondary accessions: Q5R3F9 Q9UGT6

Explore the universe of human proteins at neXtProt for CYTH4: NX_Q9UIA0

Explore proteomics data for CYTH4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYTH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037517.1  
    ENSEMBL proteins: 
     ENSP00000405442   ENSP00000248901   ENSP00000385997   ENSP00000384280   ENSP00000409579  

    CYTH4 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYTH4

     
    Search eBioscience for Proteins for CYTH4 

     
    antibodies-online proteins for CYTH4 (6 products) 

     
    antibodies-online peptides for CYTH4

    CYTH4 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 Sec7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7_dom

    Graphical View of Domain Structure for InterPro Entry Q9UIA0

    ProtoNet protein and cluster: Q9UIA0

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0
    Domain: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate (By
    similarity)
    Domain: Autoinhibited by its C-terminal basic region (By similarity)
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    Find genes that share domains with CYTH4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH4_HUMAN, Q9UIA0
    Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through
    replacement of GDP with GTP

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IDA10652308
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with CYTH4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYTH4

    miRNA
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    miRTarBase miRNAs that target CYTH4:
    hsa-mir-331-3p (MIRT043285)

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    Selected qRT-PCR Assays for microRNAs that regulate CYTH4 (see all 12):
    hsa-miR-34c-5p hsa-miR-642a hsa-miR-449b hsa-miR-486-3p hsa-miR-4290 hsa-miR-1224-5p hsa-miR-449a hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidCYTH4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYH4_HUMAN, Q9UIA0: Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IDA17398095

    Find genes that share ontologies with CYTH4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYTH4
    Interactions:

        Search GeneGlobe Interaction Network for CYTH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CYTH4 (Q9UIA03 ENSP000002489014) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IPCEF1Q8WWN93, ENSP000003561894I2D: score=1 STRING: ENSP00000356189
    CLUHENSP000003888724STRING: ENSP00000388872
    UNC50ENSP000003504094STRING: ENSP00000350409
    SLC25A3ENSP000002283184STRING: ENSP00000228318
    MYO1FENSP000003448714STRING: ENSP00000344871
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0043087regulation of GTPase activity IDA10652308

    Find genes that share ontologies with CYTH4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYTH4 (CYH4)

    1 HMDB Compound for CYTH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYTH4 gene: 
    NM_013385.3  

    Unigene Cluster for CYTH4:

    Cytohesin 4
    Hs.170944  [show with all ESTs]
    Unigene Representative Sequence: AK024428
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457992 ENST00000248901(uc003arf.3 uc011amw.2) ENST00000402997
    ENST00000405206 ENST00000469886(uc003ard.4) ENST00000462927(uc003are.2)
    ENST00000480510 ENST00000439667 ENST00000467664 ENST00000447919 ENST00000446506

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CYTH4 (see all 12):
    hsa-miR-34c-5p hsa-miR-642a hsa-miR-449b hsa-miR-486-3p hsa-miR-4290 hsa-miR-1224-5p hsa-miR-449a hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidCYTH4 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for CYTH4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYTH4
      QuantiTect SYBR Green Assays in human, mouse, rat CYTH4
      QuantiFast Probe-based Assays in human, mouse, rat CYTH4

    Additional mRNA sequence: 

    AF075458.1 AF125349.1 AK002145.1 AK024428.1 AK304453.1 AK315052.1 BC017780.1 BC033693.1 
    BC041161.1 CR456551.1 

    11 DOTS entries:

    DT.111375  DT.91691889  DT.100792587  DT.95310592  DT.120670304  DT.95266643  DT.95098736  DT.120670296 
    DT.100694185  DT.100809115  DT.120670297 

    Selected AceView cDNA sequences (see all 129):

    CD624944 AW027622 CR456551 CR610000 BM549738 H55210 BQ053130 CR626739 
    BM704910 AA827784 BU688319 BM998015 BC017780 AI567468 AI697474 CR604959 
    AF125349 Z41382 F03569 BQ890013 CR597077 BU736865 BE244616 AI445519 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYTH4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^
    SP1:                                                  -                       -           -                             -           -     -                     
    SP2:                                                  -                       -           -                                                     -     -     -   
    SP3:                                      -           -                       -           -                             -                                       
    SP4:                                                                          -           -     -     -                 -           -     -                     
    SP5:                                -     -     -     -     -     -     -     -     -     -     -                       -           -     -                     

    ExUns: 15a · 15b ^ 16a · 16b · 16c
    SP1:                              
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CYTH4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYTH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYTH4 Expression
    About this image


    CYTH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Thymus (Hematopoietic System)
    CYTH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYTH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170944

    UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0
    Tissue specificity: Expressed predominantly in peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth41 , 5 cytohesin 41, 5 86.68(n)1
    92.11(a)1
      15 (37.59 cM)5
    723181  NM_028195.31  NP_082471.21 
     785970475 
    chicken
    (Gallus gallus)
    Aves CYTH41 cytohesin 4 74.05(n)
    77.61(a)
      418043  NM_001012815.1  NP_001012833.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYTH46
    cytohesin 4
    71(a)
    1 ↔ 1
    5(22902612-22942136)
    zebrafish
    (Danio rerio)
    Actinopterygii cyth4b1 cytohesin 4b 69.78(n)
    72.21(a)
      100141338  NM_001114903.1  NP_001108375.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta step6
    steppke
    32(a)
    1 → many
    2L(21740041-21757466)
    worm
    (Caenorhabditis elegans)
    Secernentea grp-16
    Protein GRP-1 (grp-1) mRNA, complete cds
    36(a)
    1 → many
    III(8085705-8088448) WBGene00001743
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    6(a)
    1 → many
    IV(796193-802222) YDR170C


    ENSEMBL Gene Tree for CYTH4 (if available)
    TreeFam Gene Tree for CYTH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYTH4 gene
    CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  IQSEC22  
    CYTH12  FBXO82  
    8 SIMAP similar genes for CYTH4 using alignment to 7 protein entries:     CYH4_HUMAN (see all proteins):
    FLJ00017    PSCD2L    CYTH3    CYTH1    CYTH2    ARFGEF2
    FAM109A    ARFGEF1

    Find genes that share paralogs with CYTH4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYTH4 (see all 950)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs577235981,2
    C--21621865(+) ATGTG-/CGTGTGT 1 -- int10--------
    rs57565861,2
    C,F,H--37676667(+) CAAAGC/GAGTTG 1 -- us2k121Minor allele frequency- N:0.00EA NA NS WA CSA 1604
    rs1877684441,2
    --37676759(+) GGCAGA/GGCAGG 1 -- us2k10--------
    rs1418788161,2
    --37676791(+) AATCCC/TGAGCA 1 -- us2k10--------
    rs1507932931,2
    C--37676794(+) CCTGAC/GCACAC 1 -- us2k10--------
    rs119129401,2
    C,F,H--37676811(+) gggacT/Ctagta 1 -- us2k15Minor allele frequency- C:0.06NS EA WA 538
    rs354059791,2
    C--37676900(+) TTCTCT/-CCGAG 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1927191991,2
    --37676903(+) TCTCCA/GAGGAA 1 -- us2k10--------
    rs1391537261,2
    C--37676972(+) AGAAGC/TTGGTG 1 -- us2k10--------
    rs1499236021,2
    --37677009(+) CCCACA/GGTGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYTH4 (37678068 - 37711389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CYTH4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471196CNV Loss18288195
    dgv4961n71CNV Loss21882294
    nsv829203CNV Loss20364138
    nsv834190CNV Loss17160897
    nsv834188CNV Loss17160897
    nsv817992CNV Gain17921354
    nsv834189CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606514    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CYTH4:
    Mastitis

    Find genes that share disorders with CYTH4           About GenesLikeMe

    Genetic Association Database (GAD): CYTH4
    Human Genome Epidemiology (HuGE) Navigator: CYTH4 (1 document)

    Export disorders for CYTH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYTH4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CYTH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2, 9 Ogasawara M.... Vaughan M. (J. Biol. Chem. 2000)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I.... Munro S. (Curr. Biol. 2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (PubMed id 18084281)1 Morishige M....Sabe H. (Nat. Cell Biol. 2008)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27128 HGNC: 9505 AceView: PSCD4 Ensembl:ENSG00000100055 euGenes: HUgn27128
    ECgene: CYTH4 H-InvDB: CYTH4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYTH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CYTH4 gene:
    Search GeneIP for patents involving CYTH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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