Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYTH4 Gene

protein-coding   GIFtS: 53
GCID: GC22P037681

Cytohesin 4

(Previous names: pleckstrin homology, Sec7 and coiled/coil domains 4, pleckstrin...)
(Previous symbol: PSCD4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytohesin 41 2     Pleckstrin Homology, Sec7 And Coiled/Coil Domains 41 2
PSCD41 2 3 5     PH, SEC7 And Coiled-Coil Domain-Containing Protein 42 3
CYT42 3 5     DJ63G5.12
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 41 2     cytohesin-42

External Ids:    HGNC: 95051   Entrez Gene: 271282   Ensembl: ENSG000001000557   OMIM: 6065145   UniProtKB: Q9UIA03   

Export aliases for CYTH4 gene to outside databases

Previous GC identifers: GC22P036008 GC22P020643


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYTH4 Gene:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin
homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains
guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of
protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and
ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. (provided by RefSeq, Aug
2008)

GeneCards Summary for CYTH4 Gene: 
CYTH4 (cytohesin 4) is a protein-coding gene. Diseases associated with CYTH4 include mastitis, and shigellosis. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through
replacement of GDP with GTP

Gene Wiki entry for CYTH4 (PSCD4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYTH4 gene promoter:
         GR   YY1   E47   HEN1   PPAR-gamma1   STAT3   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYTH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYTH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3-q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q12.3-q13.1

CYTH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P037681:  view genomic region     (about GC identifiers)

Start:
37,678,068 bp from pter      End:
37,711,389 bp from pter
Size:
33,322 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0 (See protein sequence)
Recommended Name: Cytohesin-4  
Size: 394 amino acids; 45672 Da
Subcellular location: Cell membrane
Secondary accessions: Q5R3F9 Q9UGT6

Explore the universe of human proteins at neXtProt for CYTH4: NX_Q9UIA0

Explore proteomics data for CYTH4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIA0

  • CYTH4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYTH4 Protein Expression
    REFSEQ proteins: NP_037517.1  
    ENSEMBL proteins: 
     ENSP00000405442   ENSP00000248901   ENSP00000385997   ENSP00000384280   ENSP00000409579  

    Human Recombinant Protein Products for CYTH4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CYTH4
    OriGene Protein Over-expression Lysate for CYTH4
    OriGene MassSpec for CYTH4 
    OriGene Custom Protein Services for CYTH4
    GenScript Custom Purified and Recombinant Proteins Services for CYTH4
    Novus Biologicals CYTH4 Proteins
    Novus Biologicals CYTH4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYTH4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IDA17398095

    CYTH4 for ontologies           About GeneDecksing



    CYTH4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CYTH4
    GenScript Custom Superior Antibodies Services for CYTH4
    Novus Biologicals CYTH4 Antibodies
    Abcam antibodies for CYTH4
    Cloud-Clone Corp. Antibodies for CYTH4 
    ThermoFisher Antibodies for CYTH4
    LSBio Antibodies in human, mouse, rat for CYTH4 

    Assay Products for CYTH4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYTH4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYTH4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYTH4 
    Cloud-Clone Corp. CLIAs for CYTH4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 SEC7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7

    Graphical View of Domain Structure for InterPro Entry Q9UIA0

    ProtoNet protein and cluster: Q9UIA0

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    CYTH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH4_HUMAN, Q9UIA0
    Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through
    replacement of GDP with GTP

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    CYTH4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYTH4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYTH4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYTH4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYTH4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH4 (see all 12):
    hsa-miR-34c-5p hsa-miR-642a hsa-miR-449b hsa-miR-486-3p hsa-miR-4290 hsa-miR-1224-5p hsa-miR-449a hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidCYTH4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYTH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYTH4
    Sirion Biotech Customized adenovirus for overexpression of CYTH4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CYTH4 (see all 7)
    OriGene ORF clones in mouse, rat for CYTH4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYTH4 (NM_013385)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH4
    Sirion Biotech Customized lentivirus for stable overexpression of CYTH4 
                         Customized lentivirus expression plasmids for stable overexpression of CYTH4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYTH4
    Search LifeMap BioReagents cell lines for CYTH4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYTH4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CYTH4 (Q9UIA03 ENSP000002489014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IPCEF1Q8WWN93, ENSP000003561894I2D: score=1 STRING: ENSP00000356189
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--

    CYTH4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYTH4 (CYH4)

    1 HMDB Compound for CYTH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about CYTH4 / CYH4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYTH4 gene: 
    NM_013385.3  

    Unigene Cluster for CYTH4:

    Cytohesin 4
    Hs.170944  [show with all ESTs]
    Unigene Representative Sequence: AK024428
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457992 ENST00000248901(uc003arf.3 uc011amw.2) ENST00000402997
    ENST00000405206 ENST00000469886(uc003ard.4) ENST00000462927(uc003are.2)
    ENST00000480510 ENST00000439667 ENST00000467664 ENST00000447919 ENST00000446506

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH4 (see all 12):
    hsa-miR-34c-5p hsa-miR-642a hsa-miR-449b hsa-miR-486-3p hsa-miR-4290 hsa-miR-1224-5p hsa-miR-449a hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidCYTH4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYTH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH4
    Clone
    Products:
         
    OriGene clones in human, mouse for CYTH4 (see all 7)
    OriGene ORF clones in mouse, rat for CYTH4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYTH4 (NM_013385)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH4
    Sirion Biotech Customized lentivirus for stable overexpression of CYTH4 
                         Customized lentivirus expression plasmids for stable overexpression of CYTH4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYTH4
    OriGene qSTAR qPCR primer pairs in human, mouse for CYTH4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTH4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH4

    Additional mRNA sequence: 

    AF075458.1 AF125349.1 AK002145.1 AK024428.1 AK304453.1 AK315052.1 BC017780.1 BC033693.1 
    BC041161.1 CR456551.1 

    11 DOTS entries:

    DT.111375  DT.91691889  DT.100792587  DT.95310592  DT.120670304  DT.95266643  DT.95098736  DT.120670296 
    DT.100694185  DT.100809115  DT.120670297 

    24/129 AceView cDNA sequences (see all 129):

    F03569 AI567468 BQ890013 H55210 BM704910 CR597077 AA827784 BQ053130 
    BU688319 AI697474 CR604959 AF125349 CR456551 CR626739 CD624944 BM549738 
    CR610000 AW027622 BM998015 BU736865 BC017780 Z41382 BI060184 BE045567 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^
    SP1:                                                  -                       -           -                             -           -     -                     
    SP2:                                                  -                       -           -                                                     -     -     -   
    SP3:                                      -           -                       -           -                             -                                       
    SP4:                                                                          -           -     -     -                 -           -     -                     
    SP5:                                -     -     -     -     -     -     -     -     -     -     -                       -           -     -                     

    ExUns: 15a · 15b ^ 16a · 16b · 16c
    SP1:                              
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CYTH4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYTH4 expression in normal human tissues (normalized intensities)      CYTH4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYTH4 Expression
    About this image


    CYTH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             Cord Blood CD133- Cells   
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood CD133- Cells   
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Thymus (Hematopoietic System)

    See CYTH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYTH4

    SOURCE GeneReport for Unigene cluster: Hs.170944

    UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0
    Tissue specificity: Expressed predominantly in peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for CYTH4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYTH4
    OriGene qSTAR qPCR primer pairs in human, mouse for CYTH4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTH4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth41 , 5 cytohesin 41, 5 86.68(n)1
    92.11(a)1
      15 (37.59 cM)5
    723181  NM_028195.31  NP_082471.21 
     785970475 
    chicken
    (Gallus gallus)
    Aves CYTH41 cytohesin 4 74.05(n)
    77.61(a)
      418043  NM_001012815.1  NP_001012833.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYTH46
    cytohesin 4
    71(a)
    1 ↔ 1
    5(22902612-22942136)
    zebrafish
    (Danio rerio)
    Actinopterygii cyth4b1 cytohesin 4b 69.88(n)
    72.4(a)
      100141338  NM_001114903.1  NP_001108375.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta step6
    steppke
    32(a)
    1 ↔ 1
    2L(21740041-21757466)
    worm
    (Caenorhabditis elegans)
    Secernentea grp-16
    GTP exchange factor for ARFs 1
    36(a)
    1 ↔ 1
    III(8085704-8088448)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    5(a)
    1 → many
    IV(796193-802222)


    ENSEMBL Gene Tree for CYTH4 (if available)
    TreeFam Gene Tree for CYTH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYTH4 gene
    CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  IQSEC22  
    CYTH12  FBXO82  
    8 SIMAP similar genes for CYTH4 using alignment to 7 protein entries:     CYH4_HUMAN (see all proteins):
    FLJ00017    PSCD2L    CYTH3    CYTH1    CYTH2    ARFGEF2
    FAM109A    ARFGEF1

    CYTH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/950 SNPs in CYTH4 are shown (see all 950)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs577235981,2
    C--21621865(+) ATGTG-/CGTGTGT 1 -- int10--------
    rs57565861,2
    C,F,H--37676667(+) CAAAGC/GAGTTG 1 -- us2k121Minor allele frequency- N:0.00EA NA NS WA CSA 1604
    rs1877684441,2
    --37676759(+) GGCAGA/GGCAGG 1 -- us2k10--------
    rs1418788161,2
    --37676791(+) AATCCC/TGAGCA 1 -- us2k10--------
    rs1507932931,2
    C--37676794(+) CCTGAC/GCACAC 1 -- us2k10--------
    rs119129401,2
    C,F,H--37676811(+) gggacT/Ctagta 1 -- us2k15Minor allele frequency- C:0.06NS EA WA 538
    rs354059791,2
    C--37676900(+) TTCTCT/-CCGAG 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1927191991,2
    --37676903(+) TCTCCA/GAGGAA 1 -- us2k10--------
    rs1391537261,2
    C--37676972(+) AGAAGC/TTGGTG 1 -- us2k10--------
    rs1499236021,2
    --37677009(+) CCCACA/GGTGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYTH4 (37678068 - 37711389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CYTH4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471196CNV Loss18288195
    dgv4961n71CNV Loss21882294
    nsv829203CNV Loss20364138
    nsv834190CNV Loss17160897
    nsv834188CNV Loss17160897
    nsv817992CNV Gain17921354
    nsv834189CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYTH4
    DNA2.0 Custom Variant and Variant Library Synthesis for CYTH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606514    OMIM disorders: --

    3 diseases for CYTH4:    About MalaCards
    mastitis    shigellosis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CYTH4:
    Mastitis

    CYTH4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYTH4
    Human Genome Epidemiology (HuGE) Navigator: CYTH4 (1 document)

    Export disorders for CYTH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYTH4 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CYTH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2, 9 Ogasawara M.... Vaughan M. (2000)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I....Munro S. (2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (PubMed id 18084281)1 Morishige M....Sabe H. (2008)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27128 HGNC: 9505 AceView: PSCD4 Ensembl:ENSG00000100055 euGenes: HUgn27128
    ECgene: CYTH4 H-InvDB: CYTH4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYTH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYTH4 gene:
    Search GeneIP for patents involving CYTH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CYTH4  
     OriGene qPCR primer pairs and template standards for CYTH4   OriGene Protein Over-expression Lysate for CYTH4  
     OriGene MassSpec something-or-other for CYTH4   OriGene clones in human, mouse for CYTH4  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYTH4   OriGene Purified Protein for CYTH4  
     OriGene ORF clones in mouse, rat for CYTH4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYTH4   OriGene Custom Protein Services for CYTH4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYTH4
     QIAGEN SeqTarget long-range PCR primers for resequencing CYTH4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH4
     GenScript Custom Purified and Recombinant Proteins Services for CYTH4 GenScript cDNA clones with any tag delivered in your preferred vector for CYTH4
     GenScript Custom Assay Services for CYTH4 GenScript Custom Superior Antibodies Services for CYTH4
     GenScript Custom overexpressing Cell Line Services for CYTH4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CYTH4 promoter
     Search Chromatin IP Primers for CYTH4
     RT2 qPCR Primer Assay in human, mouse, rat CYTH4
     Search GNC Networks for CYTH4
     SABiosciences Custom PCR Arrays for CYTH4
     Search Tocris compounds for CYTH4 (CYH4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CYTH4 antibodies
     CYTH4 proteins
     CYTH4 lysates
     Antibodies for CYTH4
     See all of Abcam's Antibodies, Kits and Proteins for CYTH4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CYTH4
     Antibodies for CYTH4
     ELISAs for CYTH4
     CLIAs for CYTH4
     Search LifeMap BioReagents cell lines for CYTH4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH4
     SwitchGear 3'UTR luciferase reporter plasmids for CYTH4
     SwitchGear Promoter luciferase reporter plasmids for CYTH4
     ThermoFisher Antibodies for CYTH4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CYTH4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYTH4
    Customized:
     lentivirus for stable overexpression of CYTH4
     lentivirus expression plasmids for stable overexpression of CYTH4
     adenovirus for overexpression of CYTH4
     LSBio Antibodies in human, mouse, rat for CYTH4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYTH4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4