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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYTH4 Gene

protein-coding GIFtS: 51
GCID: GC22P037681

cytohesin 4

(Previous names: pleckstrin homology, Sec7 and coiled/coil domains 4, pleckstrin...)
(Previous symbol: PSCD4)

Explore 2 diseases affiliated with
CYTH4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytohesin 4¹ ²		Pleckstrin Homology, Sec7 And Coiled/Coil Domains 4¹ ²
CYT4¹ ² ³ ⁵		PH, SEC7 And Coiled-Coil Domain-Containing Protein 4² ³
PSCD4¹ ² ³ ⁵		DJ63G5.1²
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 4¹ ²		Cytohesin-4¹

External Ids:	HGNC: 9505¹	Entrez Gene: 27128²	Ensembl: ENSG00000100055⁷	OMIM: 606514⁵	UniProtKB: Q9UIA0³

Export aliases for CYTH4 gene to outside databases

Previous GC identifers: GC22P036008 GC22P020643

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYTH4:

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural

organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin

homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains

guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible

for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting

and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive

with ARF6. The structures of this gene and CYTH1 are very similar. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0

Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of

GDP with GTP

Gene Wiki entry for CYTH4 (PSCD4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYTH4 gene promoter:
GR YY1 E47 HEN1 PPAR-gamma1 STAT3 GR-alpha PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYTH4 promoter sequence

Search SABiosciences Chromatin IP Primers for CYTH4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3-q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q12.3-q13.1

CYTH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH4 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P037681: view genomic region (about GC identifiers)

Start:	37,678,068 bp from pter	End:	37,711,389 bp from pter
Size:	33,322 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0 (See protein sequence)

Recommended Name: Cytohesin-4

Size: 394 amino acids; 45672 Da

Subcellular location: Cell membrane

Secondary accessions: Q5R3F9 Q9UGT6

Explore the universe of human proteins at neXtProt for CYTH4: NX_Q9UIA0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UIA0

CYTH4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_037517.1

ENSEMBL proteins:

ENSP00000405442 ENSP00000248901 ENSP00000385997 ENSP00000384280 ENSP00000385940

ENSP00000409579

Human Recombinant Protein Products:

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	Novus Biologicals CYTH4 Proteins Novus Biologicals CYTH4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYTH4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005802	NOT trans-Golgi network	IBA	--
GO:0005886	plasma membrane	IDA	17398095

CYTH4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYTH4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYTH4 for domains About GeneDecksing

4 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR023394 SEC7_alpha_orthog

IPR011993 PH_like_dom

IPR000904 Sec7

Graphical View of Domain Structure for InterPro Entry Q9UIA0

ProtoNet protein and cluster: Q9UIA0

2 Blocks protein families:

IPB000904 SEC7-like domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0

Similarity: Contains 1 PH domain

Similarity: Contains 1 SEC7 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0

Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of

GDP with GTP

miRNA Products:		OriGene 3'-UTR Clone: CYTH4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH4
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH4 (see all 12):
		hsa-miR-34c-5p hsa-miR-642a hsa-miR-449b hsa-miR-486-3p hsa-miR-4290 hsa-miR-1224-5p hsa-miR-449a hsa-miR-766

		SwitchGear 3'UTR luciferase reporter plasmid: CYTH4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTH4 (see all 7) OriGene shRNA RFP: CYTH4 OriGene siRNA: CYTH4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CYTH4

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CYTH4 (NM_013385)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYTH4
		Search LifeMap BioReagents cell lines for CYTH4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005086	ARF guanyl-nucleotide exchange factor activity	IBA	--
GO:0005543	phospholipid binding	IEA	--

CYTH4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYTH4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CYTH4 (Q9UIA0³ ENSP00000248901⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IPCEF1	Q8WWN9³, ENSP00000356189⁴	I2D: score=1 STRING: ENSP00000356189

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016192	NOT vesicle-mediated transport	IBA	--
GO:0030155	regulation of cell adhesion	IBA	--
GO:0032012	regulation of ARF protein signal transduction	IEA	--

CYTH4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYTH4

1 HMDB Compound for CYTH4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about CYTH4 / CYH4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYTH4 gene:

NM_013385.3

Unigene Cluster for CYTH4:

Cytohesin 4

Hs.170944 [show with all ESTs]

Unigene Representative Sequence: AK024428

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000457992 ENST00000248901(uc003arf.3 uc011amw.2) ENST00000402997

ENST00000405206 ENST00000404204 ENST00000469886(uc003ard.4) ENST00000462927(uc003are.2)

ENST00000480510 ENST00000439667 ENST00000467664 ENST00000447919 ENST00000446506

miRNA Products:		OriGene 3'-UTR Clone: CYTH4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH4
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH4 (see all 12):
		hsa-miR-34c-5p hsa-miR-642a hsa-miR-449b hsa-miR-486-3p hsa-miR-4290 hsa-miR-1224-5p hsa-miR-449a hsa-miR-766

		SwitchGear 3'UTR luciferase reporter plasmid: CYTH4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTH4 (see all 7) OriGene shRNA RFP: CYTH4 OriGene siRNA: CYTH4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CYTH4 (NM_013385)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYTH4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH4

Additional cDNA sequence:

AF075458.1 AF125349.1 AK002145.1 AK024428.1 AK304453.1 AK315052.1 BC017780.1 BC033693.1

BC041161.1 CR456551.1

11 DOTS entries:

DT.111375 DT.91691889 DT.100792587 DT.95310592 DT.120670304 DT.95266643 DT.95098736 DT.120670296

DT.100694185 DT.100809115 DT.120670297

24/129 AceView cDNA sequences (see all 129):

CD624944 BQ890013 F03569 CR626739 H55210 CR456551 AF125349 AW027622

CR610000 AA827784 BQ053130 BM549738 BM998015 AI567468 BM704910 Z41382

CR604959 AI697474 CR597077 BU736865 BU688319 BC017780 BC033693 T23578

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH4 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^
SP1:																	-								-				-										-				-		-
SP2:																	-								-				-																		-		-		-
SP3:													-				-								-				-										-
SP4:																									-				-		-		-						-				-		-
SP5:											-		-		-		-		-		-		-		-		-		-		-								-				-		-

ExUns:	15a	·	15b	^	16a	·	16b	·	16c
SP1:
SP2:	-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CYTH4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYTH4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CYTH4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Periosteum

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYTH4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYTH4

SOURCE GeneReport for Unigene cluster: Hs.170944

UniProtKB/Swiss-Prot: CYH4_HUMAN, Q9UIA0

Tissue specificity: Expressed predominantly in peripheral blood leukocytes

SABiosciences Custom PCR Arrays for CYTH4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CYTH4 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYTH4¹	cytohesin 4	74.05(n) 77.61(a)		418043 NM_001012815.1 NP_001012833.1
lizard (Anolis carolinensis)	Reptilia	CYTH4⁶	--	75(a)	1 ↔ 1	5(22916217-22942379)
zebrafish (Danio rerio)	Actinopterygii	cyth4b¹	cytohesin 4b	69.88(n) 72.4(a)		100141338 NM_001114903.1 NP_001108375.1
fruit fly (Drosophila melanogaster)	Insecta	step⁶	steppke	31(a)	possible ortholog	2L(21740041-21757466)
worm (Caenorhabditis elegans)	Secernentea	grp-1⁶	GTP exchange factor for ARFs 1	34(a)	1 → many	III(8085638-8088382)

ENSEMBL Gene Tree for CYTH4 (if available)
TreeFam Gene Tree for CYTH4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYTH4 gene

PSD3² GBF1² CYTH3² IQSEC3² CYTH2² ARFGEF2² PSD4² ARFGEF1²

IQSEC1² PSD2² PSD² IQSEC2² CYTH1² FBXO8²

8 SIMAP similar genes for CYTH4 using alignment to 7 protein entries: CYH4_HUMAN (see all proteins):

FLJ00017 PSCD2L CYTH3 CYTH1 CYTH2 ARFGEF2

FAM109A ARFGEF1

CYTH4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5756586^1,2	C,F,H,	--	37676667(+)	`CAAAGC/GAGTTG`	1	--	us2k¹		21		EA NA NS WA CSA	1604
rs187768444^1,2		--	37676759(+)	`GGCAGA/GGCAGG`	1	--	us2k¹		0	--	--	--	--
rs141878816^1,2		--	37676791(+)	`AATCCC/TGAGCA`	1	--	us2k¹		0	--	--	--	--
rs150793293^1,2		--	37676794(+)	`CCTGAC/GCACAC`	1	--	us2k¹		0	--	--	--	--
rs11912940^1,2	C,F,H,	--	37676811(+)	`gggacT/Ctagta`	1	--	us2k¹		5		NS EA WA	538
rs35405979^1,2	C,	--	37676900(+)	`TTCTCT/-CCGAG`	1	--	us2k¹		1		NA	2
rs192719199^1,2		--	37676903(+)	`TCTCCA/GAGGAA`	1	--	us2k¹		0	--	--	--	--
rs139153726^1,2		--	37676972(+)	`AGAAGC/TTGGTG`	1	--	us2k¹		0	--	--	--	--
rs149923602^1,2		--	37677009(+)	`CCCACA/GGTGCT`	1	--	us2k¹		0	--	--	--	--
rs117943003^1,2		--	37677036(+)	`GGTGGG/TACTCC`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for CYTH4 (37678068 - 37711389 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CYTH4
4 CNVs: 30163 30162 5184 9846

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYTH4

DNA2.0 Custom Variant and Variant Library Synthesis for CYTH4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYTH4 for disorders           About GeneDecksing

OMIM gene information: 606514    OMIM disorders: --

2 diseases for CYTH4:    About MalaCards

shigellosis breast cancer

1 disease from the University of Copenhagen DISEASES database for CYTH4:

Mastitis

Human Genome Epidemiology (HuGE) Navigator: CYTH4 (1 document)

Export disorders for CYTH4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYTH4 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CYTH4)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)^{1, 2, 9} Ogasawara M.... Vaughan M. (2000)
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)^{1, 2, 9} Hofmann I....Munro S. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (PubMed id 18084281)¹ Morishige M....Sabe H. (2008)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)¹ Beausoleil S.A....Gygi S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27128	HGNC: 9505	AceView: PSCD4	Ensembl:ENSG00000100055	euGenes: HUgn27128
ECgene: CYTH4	H-InvDB: CYTH4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYTH4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYTH4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CYTH4 gene:
Search GeneIP for patents involving CYTH4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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