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CYTH3 Gene

protein-coding   GIFtS: 57
GCID: GC07M006168

Cytohesin 3

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains 3)
(Previous symbol: PSCD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytohesin 31 2     ARF Nucleotide-Binding Site Opener 32 3
PSCD31 2 3 5     PH, SEC7 And Coiled-Coil Domain-Containing Protein 32 3
ARNO32 3 5     cytohesin-32
GRP12 3 5     Grp13
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 31 2     Protein ARNO33
General Receptor Of Phosphoinositides 12 3     

External Ids:    HGNC: 95041   Entrez Gene: 92652   Ensembl: ENSG000000082567   OMIM: 6050815   UniProtKB: O437393   

Export aliases for CYTH3 gene to outside databases

Previous GC identifer: GC07M006073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYTH3 Gene:
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family
members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7
domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization,
the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with
phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to
mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the
control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation
factor protein 6 (ARF) functions, in addition to acting on ARF1. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYTH3 Gene:
CYTH3 (cytohesin 3) is a protein-coding gene. Diseases associated with CYTH3 include thyroiditis, and hepatitis. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity and 1-phosphatidylinositol binding. An important paralog of this gene is IQSEC3.

UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through
replacement of GDP with GTP

Gene Wiki entry for CYTH3 (PSCD3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYTH3 gene promoter:
         MyoD   MEF-2A   POU2F1   POU2F1b   POU2F1a   POU2F1c   aMEF-2   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CYTH3 promoter sequence
   Search Chromatin IP Primers for CYTH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYTH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

CYTH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M006168:  view genomic region     (about GC identifiers)

Start:
6,201,407 bp from pter      End:
6,312,275 bp from pter
Size:
110,869 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,247,766-6,358,597     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739 (See protein sequence)
Recommended Name: Cytohesin-3  
Size: 400 amino acids; 46349 Da
Subunit: Interacts with GRASP (By similarity). Interacts with ARF6
1 PDB 3D structure from and Proteopedia for CYTH3:
4KAX (3D)    
Secondary accessions: A4D2N8
Alternative splicing: 2 isoforms:  O43739-1   O43739-2   

Explore the universe of human proteins at neXtProt for CYTH3: NX_O43739

Explore proteomics data for CYTH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYTH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004218.1  
    ENSEMBL proteins: 
     ENSP00000297044   ENSP00000379967  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 Sec7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7_dom

    Graphical View of Domain Structure for InterPro Entry O43739

    ProtoNet protein and cluster: O43739

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Domain: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate
    Domain: Autoinhibited by its C-terminal basic region
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    CYTH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH3_HUMAN, O43739
    Function: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through
    replacement of GDP with GTP

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IDA--
    GO:0005515protein binding ----
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA--
         
    CYTH3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYTH3:
     Cell division defect 

    Animal Models:
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    hsa-mir-320a (MIRT044672), hsa-mir-335-5p (MIRT018199)

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    Selected qRT-PCR Assays for microRNAs that regulate CYTH3 (see all 64):
    hsa-miR-323-3p hsa-miR-374a hsa-miR-508-5p hsa-miR-200b hsa-miR-601 hsa-let-7i hsa-miR-3922-3p hsa-let-7e
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYH3_HUMAN, O43739: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the
    cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm ----
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005829cytosol IDA9742223
    GO:0005886plasma membrane IDA17398095

    CYTH3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYTH3 About    
    See pathways by source

    SuperPathContained pathways About
    1Development Angiotensin activation of ERK
    Cell adhesion Integrin inside out signaling0.44
    2Insulin Signaling
    Insulin Signaling
    3Class I PI3K signaling events
    Class I PI3K signaling events
    4Arf6 signaling events
    Arf6 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYTH3
        Cell adhesion Integrin inside-out signaling

    3 BioSystems Pathways for CYTH3
        Insulin Signaling
    Class I PI3K signaling events
    Arf6 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYTH3
    Interactions:

        GeneGlobe Interaction Network for CYTH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CYTH3 (O437392, 3 ENSP000002970444) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-68123 I2D: score=5 STRING: ENSP00000262059
    CNKSR1Q969H42, 3, ENSP000003546094MINT-66188 I2D: score=5 STRING: ENSP00000354609
    FRMD4BQ9Y2L63, ENSP000003815494I2D: score=1 STRING: ENSP00000381549
    GRASPQ7Z6J23, ENSP000002936624I2D: score=1 STRING: ENSP00000293662
    CYTIPO607593, ENSP000002641924I2D: score=1 STRING: ENSP00000264192
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0043087regulation of GTPase activity IDA--
    GO:0045785positive regulation of cell adhesion IEA--

    CYTH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYTH3 (CYH3)

    1 HMDB Compound for CYTH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for CYTH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423 10592235
    Inositol-(1,3,4,5,6)-Pentakisphosphate-- --target--17139284 17016423 10592235

    10 Novoseek inferred chemical compound relationships for CYTH3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 99.3 79 10480924 (8), 11445584 (6), 9742223 (5), 10605025 (5) (see all 18)
    phosphatidylinositol-3,4,5-trisphosphate 88.2 4 11210545 (1), 10983985 (1), 19636878 (1), 10585883 (1)
    nitrilotriacetic acid 74.8 1 10913124 (1)
    phosphoinositide 57.9 1 10983985 (1)
    phosphatidylinositol 53.6 3 9742223 (1), 11445584 (1)
    gtp 39.1 5 10480924 (3)
    inositol 36.8 1 9742223 (1)
    lipid 21.8 1 9742223 (1)
    adp 21.7 1 9707577 (1)
    glucose 0 1 9832437 (1)



    CYTH3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYTH3 gene: 
    NM_004227.3  

    Unigene Cluster for CYTH3:

    Cytohesin 3
    Hs.487479  [show with all ESTs]
    Unigene Representative Sequence: BC028717
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350796(uc011jws.2 uc003spt.3) ENST00000465320 ENST00000495176
    ENST00000461891 ENST00000488964 ENST00000466543 ENST00000491641 ENST00000478541
    ENST00000481329 ENST00000482460 ENST00000396741
    miRNA
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    hsa-miR-323-3p hsa-miR-374a hsa-miR-508-5p hsa-miR-200b hsa-miR-601 hsa-let-7i hsa-miR-3922-3p hsa-let-7e
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    Additional mRNA sequence: 

    AJ005197.1 AJ223957.1 AK023609.1 AK295163.1 AK313728.1 BC008191.1 BC028717.1 

    12 DOTS entries:

    DT.115494  DT.91751503  DT.121045961  DT.121045975  DT.100754860  DT.40208443  DT.91937315  DT.92000647 
    DT.121045941  DT.121046022  DT.92009308  DT.100754859 

    Selected AceView cDNA sequences (see all 184):

    BC028717 CA430257 AW182194 BQ009582 CA424093 BX097016 BQ015806 AI685308 
    CA422558 AI924296 AW183322 CA445601 BM844079 AI187753 CN483229 AW780395 
    CB529534 AA883318 AW337945 AI079981 T33202 BQ477486 AI885568 AI984940 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYTH3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                      -     -                 -     -                       -                 -                                             
    SP2:                                                              -     -                       -           -     -     -     -     -     -     -               
    SP3:                                                                                                              -                                             
    SP4:                                                                                                              -     -     -                                 
    SP5:                                                                                                                    -     -                                 


    ECgene alternative splicing isoforms for CYTH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYTH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGTTAAA
    CYTH3 Expression
    About this image

    CYTH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYTH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487479

    UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Tissue specificity: Almost absent from liver, thymus and peripheral blood lymphocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth31 , 5 cytohesin 31, 5 88.05(n)1
    99(a)1
      5 (82.36 cM)5
    191591  NM_011182.41  NP_035312.31 
     1436224475 
    chicken
    (Gallus gallus)
    Aves CYTH31 cytohesin 3 79.62(n)
    97.59(a)
      416626  XM_004945306.1  XP_004945363.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYTH36
    cytohesin 3
    95(a)
    1 ↔ 1
    GL343507.1(140215-178422)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cyth31 cytohesin 3 78.46(n)
    96.78(a)
      780343  NM_001079413.2  NP_001072881.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005374481 cytohesin-3-like 78.46(n)
    94.37(a)
      100537448  XM_003198177.2  XP_003198225.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta step6
    steppke
    35(a)
    1 → many
    2L(21740041-21757466)
    worm
    (Caenorhabditis elegans)
    Secernentea grp-11 grp-1 50.34(n)
    44.35(a)
      176140  NM_066363.3  NP_498764.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    6(a)
    1 → many
    IV(796193-802222) YDR170C


    ENSEMBL Gene Tree for CYTH3 (if available)
    TreeFam Gene Tree for CYTH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYTH3 gene
    IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  CYTH42  IQSEC22  
    CYTH12  FBXO82  
    9 SIMAP similar genes for CYTH3 using alignment to 3 protein entries:     CYH3_HUMAN (see all proteins):
    PSCD2L    CYTH1    CYTH2    CYTH4    FLJ00017    ARFGEF2
    ARFGEF1    FAM109A    IQSEC1

    CYTH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYTH3 (see all 2698)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448572841,2
    --6173069(+) GTGGGA/GAAAAC 1 -- ds50010--------
    rs1386551511,2
    --6173239(+) CAGCAA/CATCAC 1 -- ds50010--------
    rs1492409941,2
    --6173349(+) CTGCCA/GAAGTC 1 -- ds50010--------
    rs69597401,2
    C,F,A,H--6173355(+) AAGTCG/AGCACC 1 -- ds500117Minor allele frequency- A:0.20NS EA NA WA 2052
    rs1115625831,2
    F--6173445(+) AGAACC/TAAGTC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1480070541,2
    C--6173470(+) ACAATA/GCATGT 1 -- ut310--------
    rs1887096401,2
    --6173517(+) CTGACA/GGCCAT 1 -- ut310--------
    rs1811951601,2
    --6173673(+) GCAAAA/TAGAAA 1 -- ut310--------
    rs1853023771,2
    --6173825(+) ATCTAC/TAAATA 1 -- ut310--------
    rs1434788051,2
    --6173894(+) AGACAA/CAAAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CYTH3 (6201407 - 6312275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CYTH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    dgv403n21CNV Loss19592680
    nsv5629CNV Loss18451855
    dgv7146n71CNV Loss21882294
    nsv818475CNV Loss17921354
    nsv522155CNV Loss19592680
    esv8077CNV Gain19470904
    esv1914954OTHER Inversion16254605
    nsv7392OTHER Inversion18451855
    esv259693OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYTH3
    DNA2.0 Custom Variant and Variant Library Synthesis for CYTH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605081    OMIM disorders: --

    3 diseases for CYTH3:    
    About MalaCards
    thyroiditis    hepatitis    breast cancer


    CYTH3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYTH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 11059789 (3)


    Export disorders for CYTH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYTH3 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with CYTH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. (PubMed id 9742223)1, 2, 9 Venkateswarlu K.... Cullen P.J. (Biochem. J. 1998)
    2. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. (PubMed id 9707577)1, 2, 9 Franco M....Chavrier P. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I.... Munro S. (Curr. Biol. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2 Ogasawara M.... Vaughan M. (J. Biol. Chem. 2000)
    7. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. (PubMed id 9072969)1, 3 Klarlund J.K....Czech M.P. (Science 1997)
    8. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. (PubMed id 11445584)1, 9 Klarlund J.K....Czech M.P. (J. Biol. Chem. 2001)
    9. Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. (PubMed id 23940353)2 Malaby A.W.... Lambright D.G. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. Phosphoinositide specificity determines which cytohesins regulate I^1 integrin recycling. (PubMed id 22454518)1 Oh S.J. and Santy L.C. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9265 HGNC: 9504 AceView: PSCD3 Ensembl:ENSG00000008256 euGenes: HUgn9265
    ECgene: CYTH3 H-InvDB: CYTH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYTH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYTH3 gene:
    Search GeneIP for patents involving CYTH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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