Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYTH3 Gene

protein-coding   GIFtS: 58
GCID: GC07M006168

Cytohesin 3

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains 3)
(Previous symbol: PSCD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytohesin 31 2     ARF Nucleotide-Binding Site Opener 32 3
PSCD31 2 3 5     PH, SEC7 And Coiled-Coil Domain-Containing Protein 32 3
ARNO32 3 5     cytohesin-32
GRP12 3 5     Grp13
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 31 2     Protein ARNO33
General Receptor Of Phosphoinositides 12 3     

External Ids:    HGNC: 95041   Entrez Gene: 92652   Ensembl: ENSG000000082567   OMIM: 6050815   UniProtKB: O437393   

Export aliases for CYTH3 gene to outside databases

Previous GC identifer: GC07M006073


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYTH3 Gene:
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family
members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7
domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization,
the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with
phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to
mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the
control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation
factor protein 6 (ARF) functions, in addition to acting on ARF1. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYTH3 Gene: 
CYTH3 (cytohesin 3) is a protein-coding gene. Diseases associated with CYTH3 include thyroiditis, and hepatitis, and among its related super-pathways are Development Angiotensin activation of ERK. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity and 1-phosphatidylinositol binding. An important paralog of this gene is IQSEC3.

UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
Function: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP
with GTP

Gene Wiki entry for CYTH3 (PSCD3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYTH3 gene promoter:
         MyoD   MEF-2A   POU2F1   POU2F1b   POU2F1a   POU2F1c   aMEF-2   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CYTH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYTH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

CYTH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M006168:  view genomic region     (about GC identifiers)

Start:
6,201,407 bp from pter      End:
6,312,275 bp from pter
Size:
110,869 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,247,766-6,358,597     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739 (See protein sequence)
Recommended Name: Cytohesin-3  
Size: 400 amino acids; 46349 Da
Subunit: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate with high
affinity. Interacts with GRASP (By similarity)
Subcellular location: Cell membrane
Secondary accessions: A4D2N8
Alternative splicing: 2 isoforms:  O43739-1   O43739-2   

Explore the universe of human proteins at neXtProt for CYTH3: NX_O43739

Explore proteomics data for CYTH3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43739

  • CYTH3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYTH3 Protein Expression
    REFSEQ proteins: NP_004218.1  
    ENSEMBL proteins: 
     ENSP00000297044   ENSP00000379967  

    Human Recombinant Protein Products for CYTH3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CYTH3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CYTH3
    GenScript Custom Purified and Recombinant Proteins Services for CYTH3
    Novus Biologicals CYTH3 Protein
    Novus Biologicals CYTH3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYTH3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IEA--
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IDA17398095
    GO:0016020membrane TAS9742223

    CYTH3 for ontologies           About GeneDecksing



    CYTH3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CYTH3
    OriGene Custom Antibody Services for CYTH3
    GenScript Custom Superior Antibodies Services for CYTH3
    Novus Biologicals CYTH3 Antibodies
    Abcam antibodies for CYTH3
    Cloud-Clone Corp. Antibodies for CYTH3 
    ThermoFisher Antibodies for CYTH3
    LSBio Antibodies in human, mouse, rat for CYTH3 

    Assay Products for CYTH3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYTH3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYTH3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYTH3 
    Cloud-Clone Corp. CLIAs for CYTH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 SEC7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7

    Graphical View of Domain Structure for InterPro Entry O43739

    ProtoNet protein and cluster: O43739

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    CYTH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH3_HUMAN, O43739
    Function: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP
    with GTP

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity TAS9742223
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding TAS9742223
         
    CYTH3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYTH3:
     Cell division defect 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYTH3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYTH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYTH3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYTH3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH3
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH3 (see all 64):
    hsa-miR-323-3p hsa-miR-374a hsa-miR-508-5p hsa-miR-200b hsa-miR-601 hsa-let-7i hsa-miR-3922-3p hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYTH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYTH3
    Sirion Biotech Customized adenovirus for overexpression of CYTH3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CYTH3 (see all 8)
    OriGene ORF clones in mouse, rat for CYTH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYTH3 (NM_004227)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH3
    Sirion Biotech Customized lentivirus for stable overexpression of CYTH3 
                         Customized lentivirus expression plasmids for stable overexpression of CYTH3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYTH3
    Search LifeMap BioReagents cell lines for CYTH3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYTH3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development Angiotensin activation of ERK
    Cell adhesion Integrin inside-out signaling0.44
    2Insulin Signaling
    Insulin Signaling
    3Class I PI3K signaling events
    Class I PI3K signaling events
    4Arf6 signaling events
    Arf6 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CYTH3
        Cell adhesion Integrin inside-out signaling


    1 GeneGo (Thomson Reuters) Pathway for CYTH3
        Cell adhesion Integrin inside-out signaling

    3 BioSystems Pathways for CYTH3
        Insulin Signaling
    Arf6 signaling events
    Class I PI3K signaling events



    CYTH3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYTH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CYTH3 (O437392, 3 ENSP000002970444) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-68123 I2D: score=5 STRING: ENSP00000262059
    CNKSR1Q969H42, 3, ENSP000003546094MINT-66188 I2D: score=5 STRING: ENSP00000354609
    FRMD4BQ9Y2L63, ENSP000003815494I2D: score=1 STRING: ENSP00000381549
    GRASPQ7Z6J23, ENSP000002936624I2D: score=1 STRING: ENSP00000293662
    CYTIPO607593, ENSP000002641924I2D: score=1 STRING: ENSP00000264192
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0045785positive regulation of cell adhesion IEA--
    GO:0048016inositol phosphate-mediated signaling TAS9742223

    CYTH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYTH3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYTH3 (CYH3)

    1 HMDB Compound for CYTH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for CYTH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423 10592235
    Inositol-(1,3,4,5,6)-Pentakisphosphate-- --target--17139284 17016423 10592235

    10 Novoseek inferred chemical compound relationships for CYTH3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 99.3 79 10480924 (8), 11445584 (6), 9742223 (5), 10605025 (5) (see all 18)
    phosphatidylinositol-3,4,5-trisphosphate 88.2 4 11210545 (1), 10983985 (1), 19636878 (1), 10585883 (1)
    nitrilotriacetic acid 74.8 1 10913124 (1)
    phosphoinositide 57.9 1 10983985 (1)
    phosphatidylinositol 53.6 3 9742223 (1), 11445584 (1)
    gtp 39.1 5 10480924 (3)
    inositol 36.8 1 9742223 (1)
    lipid 21.8 1 9742223 (1)
    adp 21.7 1 9707577 (1)
    glucose 0 1 9832437 (1)

    Search CenterWatch for drugs/clinical trials and news about CYTH3 / CYH3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYTH3 gene: 
    NM_004227.3  

    Unigene Cluster for CYTH3:

    Cytohesin 3
    Hs.487479  [show with all ESTs]
    Unigene Representative Sequence: BC028717
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350796(uc011jws.2 uc003spt.3) ENST00000465320 ENST00000495176
    ENST00000461891 ENST00000488964 ENST00000466543 ENST00000491641 ENST00000478541
    ENST00000481329 ENST00000482460 ENST00000396741
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH3
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH3 (see all 64):
    hsa-miR-323-3p hsa-miR-374a hsa-miR-508-5p hsa-miR-200b hsa-miR-601 hsa-let-7i hsa-miR-3922-3p hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYTH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH3
    Clone
    Products:
         
    OriGene clones in human, mouse for CYTH3 (see all 8)
    OriGene ORF clones in mouse, rat for CYTH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYTH3 (NM_004227)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH3
    Sirion Biotech Customized lentivirus for stable overexpression of CYTH3 
                         Customized lentivirus expression plasmids for stable overexpression of CYTH3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYTH3
    OriGene qSTAR qPCR primer pairs in human, mouse for CYTH3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTH3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH3

    Additional mRNA sequence: 

    AJ005197.1 AJ223957.1 AK023609.1 AK295163.1 AK313728.1 BC008191.1 BC028717.1 

    12 DOTS entries:

    DT.115494  DT.91751503  DT.121045961  DT.121045975  DT.100754860  DT.40208443  DT.91937315  DT.92000647 
    DT.121045941  DT.121046022  DT.92009308  DT.100754859 

    24/184 AceView cDNA sequences (see all 184):

    CA422558 BU616631 BM670382 CN483229 AI745547 CR594486 CA430257 CA445601 
    AW780395 BG571309 CA396806 NM_004227 BI828541 AW074695 BM844079 BQ015085 
    AI127947 AI685308 BQ009582 BX097016 BM712092 AI187753 AW043741 BQ015806 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                      -     -                 -     -                       -                 -                                             
    SP2:                                                              -     -                       -           -     -     -     -     -     -     -               
    SP3:                                                                                                              -                                             
    SP4:                                                                                                              -     -     -                                 
    SP5:                                                                                                                    -     -                                 


    ECgene alternative splicing isoforms for CYTH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYTH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGTTAAA
    CYTH3 Expression
    About this image


    See CYTH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYTH3

    SOURCE GeneReport for Unigene cluster: Hs.487479

    UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Tissue specificity: Almost absent from liver, thymus and peripheral blood lymphocytes

        SABiosciences Custom PCR Arrays for CYTH3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYTH3
    OriGene qSTAR qPCR primer pairs in human, mouse for CYTH3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTH3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth31 , 5 cytohesin 31, 5 88.05(n)1
    99(a)1
      5 (82.36 cM)5
    191591  NM_011182.41  NP_035312.31 
     1436224475 
    chicken
    (Gallus gallus)
    Aves CYTH31 cytohesin 3 80.1(n)
    96.73(a)
      416626  XM_414927.3  XP_414927.2 
    lizard
    (Anolis carolinensis)
    Reptilia CYTH36
    cytohesin 3
    95(a)
    1 ↔ 1
    GL343507.1(140215-178422)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005374481 cytohesin-3-like 78.44(n)
    93.81(a)
      100537448  XM_003198177.1  XP_003198225.1 
    worm
    (Caenorhabditis elegans)
    Secernentea grp-11 Protein GRP-1 49.51(n)
    43.4(a)
      176140  NM_066363.2  NP_498764.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    6(a)
    1 → many
    IV(796193-802222)


    ENSEMBL Gene Tree for CYTH3 (if available)
    TreeFam Gene Tree for CYTH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYTH3 gene
    IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  CYTH42  IQSEC22  
    CYTH12  FBXO82  
    9 SIMAP similar genes for CYTH3 using alignment to 3 protein entries:     CYH3_HUMAN (see all proteins):
    PSCD2L    CYTH1    CYTH2    CYTH4    FLJ00017    ARFGEF2
    ARFGEF1    FAM109A    IQSEC1

    CYTH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2698 SNPs in CYTH3 are shown (see all 2698)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448572841,2
    --6173069(+) GTGGGA/GAAAAC 1 -- ds50010--------
    rs1386551511,2
    --6173239(+) CAGCAA/CATCAC 1 -- ds50010--------
    rs1492409941,2
    --6173349(+) CTGCCA/GAAGTC 1 -- ds50010--------
    rs69597401,2
    C,F,A,H--6173355(+) AAGTCG/AGCACC 1 -- ds500117Minor allele frequency- A:0.20NS EA NA WA 2052
    rs1115625831,2
    F--6173445(+) AGAACC/TAAGTC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1480070541,2
    C--6173470(+) ACAATA/GCATGT 1 -- ut310--------
    rs1887096401,2
    --6173517(+) CTGACA/GGCCAT 1 -- ut310--------
    rs1811951601,2
    --6173673(+) GCAAAA/TAGAAA 1 -- ut310--------
    rs1853023771,2
    --6173825(+) ATCTAC/TAAATA 1 -- ut310--------
    rs1434788051,2
    --6173894(+) AGACAA/CAAAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CYTH3 (6201407 - 6312275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CYTH3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    dgv403n21CNV Loss19592680
    nsv5629CNV Loss18451855
    dgv7146n71CNV Loss21882294
    nsv818475CNV Loss17921354
    nsv522155CNV Loss19592680
    esv8077CNV Gain19470904
    esv1914954OTHER Inversion16254605
    nsv7392OTHER Inversion18451855
    esv259693OTHER Complex20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYTH3
    DNA2.0 Custom Variant and Variant Library Synthesis for CYTH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605081    OMIM disorders: --

    3 diseases for CYTH3:    About MalaCards
    thyroiditis    hepatitis    breast cancer


    CYTH3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYTH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 11059789 (3)


    Export disorders for CYTH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYTH3 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with CYTH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. (PubMed id 9742223)1, 2, 9 Venkateswarlu K.... Cullen P.J. (1998)
    2. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. (PubMed id 9707577)1, 2, 9 Franco M....Chavrier P. (1998)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I....Munro S. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    6. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2 Ogasawara M.... Vaughan M. (2000)
    7. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. (PubMed id 9072969)1, 3 Klarlund J.K....Czech M.P. (1997)
    8. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. (PubMed id 11445584)1, 9 Klarlund J.K....Czech M.P. (2001)
    9. Phosphoinositide specificity determines which cytohesi ns regulate b1 integrin recycling. (PubMed id 22454518)1 Oh S.J. and Santy L.C. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9265 HGNC: 9504 AceView: PSCD3 Ensembl:ENSG00000008256 euGenes: HUgn9265
    ECgene: CYTH3 H-InvDB: CYTH3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYTH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYTH3 gene:
    Search GeneIP for patents involving CYTH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CYTH3   OriGene RNAi products in human, mouse, rat for CYTH3  
     OriGene qPCR primer pairs and template standards for CYTH3   OriGene Protein Over-expression Lysate for CYTH3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CYTH3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYTH3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CYTH3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYTH3   OriGene Custom Protein Services for CYTH3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYTH3
     QIAGEN SeqTarget long-range PCR primers for resequencing CYTH3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH3
     GenScript Custom Purified and Recombinant Proteins Services for CYTH3 GenScript cDNA clones with any tag delivered in your preferred vector for CYTH3
     GenScript Custom Assay Services for CYTH3 GenScript Custom Superior Antibodies Services for CYTH3
     GenScript Custom overexpressing Cell Line Services for CYTH3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CYTH3 promoter
     Search Chromatin IP Primers for CYTH3
     RT2 qPCR Primer Assay in human, mouse, rat CYTH3
     GNC Network for CYTH3
     SABiosciences Custom PCR Arrays for CYTH3
     Search Tocris compounds for CYTH3 (CYH3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CYTH3 antibodies
     CYTH3 proteins
     CYTH3 lysates
     Antibodies for CYTH3
     See all of Abcam's Antibodies, Kits and Proteins for CYTH3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CYTH3
     Antibodies for CYTH3
     ELISAs for CYTH3
     CLIAs for CYTH3
     Search LifeMap BioReagents cell lines for CYTH3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CYTH3
     SwitchGear Promoter luciferase reporter plasmids for CYTH3
     ThermoFisher Antibodies for CYTH3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CYTH3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYTH3
    Customized:
     lentivirus for stable overexpression of CYTH3
     lentivirus expression plasmids for stable overexpression of CYTH3
     adenovirus for overexpression of CYTH3
     LSBio Antibodies in human, mouse, rat for CYTH3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYTH3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4