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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYTH3 Gene

protein-coding   GIFtS: 59
GCID: GC07M006168

cytohesin 3

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains 3 )
(Previous symbol: PSCD3)
 Explore 3 diseases affiliated with
CYTH3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYTH3    

Aliases
for CYTH3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytohesin 31 2     ARF Nucleotide-Binding Site Opener 32 3
ARNO31 2 3 5     PH, SEC7 And Coiled-Coil Domain-Containing Protein 32 3
GRP11 2 3 5     Cytohesin-31
PSCD31 2 3 5     Grp13
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 31 2     Protein ARNO33
General Receptor Of Phosphoinositides 12 3     

External Ids:    HGNC: 95041   Entrez Gene: 92652   Ensembl: ENSG000000082567   OMIM: 6050815   UniProtKB: O437393   

Export aliases for CYTH3 gene to outside databases

Previous GC identifer: GC07M006073


Summaries
for CYTH3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYTH3:
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members
have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a
C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain
contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of
protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and
function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in
addition to acting on ARF1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
Function: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with
GTP

Gene Wiki entry for CYTH3 (PSCD3)


Genomic Views
for CYTH3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYTH3 gene promoter:
         MyoD   MEF-2A   POU2F1   POU2F1b   POU2F1a   POU2F1c   aMEF-2   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CYTH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYTH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

CYTH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M006168:  view genomic region     (about GC identifiers)

Start:
 6,201,407 bp from pter      End:
 6,312,275 bp from pter
Size:
 110,869 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,247,766-6,358,597     

Proteins
for CYTH3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739 (See protein sequence)
Recommended Name: Cytohesin-3  
Size: 400 amino acids; 46349 Da
Subunit: Binds via its PH domain to the inositol head group of phosphotidylinositol 3,4,5-trisphosphate with high
affinity. Interacts with GRASP (By similarity)
Subcellular location: Cell membrane
Secondary accessions: A4D2N8
Alternative splicing: 2 isoforms:  O43739-1   O43739-2   

Explore the universe of human proteins at neXtProt for CYTH3: NX_O43739

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43739

    • CYTH3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004218.1  
    ENSEMBL proteins: 
     ENSP00000297044   ENSP00000379967  

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    Uscn Proteins for CYTH3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IDA17398095


    CYTH3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CYTH3

    Protein Domains /
    Families
    for CYTH3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYTH3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR023394 SEC7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7

    Graphical View of Domain Structure for InterPro Entry O43739

    ProtoNet protein and cluster: O43739

    2 Blocks protein families:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    Function
    for CYTH3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Function: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with
    GTP

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    hsa-miR-323-3p hsa-miR-374a hsa-miR-508-5p hsa-miR-200b hsa-miR-601 hsa-let-7i hsa-miR-3922-3p hsa-let-7e
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity TAS9742223
    GO:0005515protein binding ----
    GO:00055451-phosphatidylinositol binding TAS9742223
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IEA--


    CYTH3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CYTH3:
     Cell division defect 


    Pathways & Interactions
    for CYTH3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin inside-out signaling
    		Cell adhesion_Integrin inside-out signaling1.00
    		Cell adhesion Integrin inside-out signaling0.99
    2Insulin Signaling
    		Insulin Signaling1.00
    3Arf6 signaling events
    		Arf6 signaling events1.00
    4Class I PI3K signaling events
    		Class I PI3K signaling events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CYTH3
        Cell adhesion Integrin inside-out signaling


    1 GeneGo (Thomson Reuters) Pathway for CYTH3
        Cell adhesion Integrin inside-out signaling

    3 BioSystems Pathways for CYTH3 
        Insulin Signaling
    Arf6 signaling events
    Class I PI3K signaling events



    CYTH3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYTH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CYTH3 (O437392, 3 ENSP000002970444) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-68123 I2D: score=5 STRING: ENSP00000262059
    CNKSR1Q969H42, 3, ENSP000003546094MINT-66188 I2D: score=5 STRING: ENSP00000354609
    FRMD4BQ9Y2L63, ENSP000003815494I2D: score=1 STRING: ENSP00000381549
    GRASPQ7Z6J23, ENSP000002936624I2D: score=1 STRING: ENSP00000293662
    CYTIPO607593, ENSP000002641924I2D: score=1 STRING: ENSP00000264192
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0045785positive regulation of cell adhesion IEA--
    GO:0048016inositol phosphate-mediated signaling TAS9742223


    CYTH3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYTH3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYTH3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYTH3

    1 HMDB Compound for CYTH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for CYTH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423 10592235
    Inositol-(1,3,4,5,6)-Pentakisphosphate-- --target--17139284 17016423 10592235

    10 Novoseek chemical compound relationships for CYTH3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 99.3 79 10480924 (8), 11445584 (6), 9742223 (5), 10605025 (5) (see all 18)
    phosphatidylinositol-3,4,5-trisphosphate 88.2 4 11210545 (1), 10983985 (1), 19636878 (1), 10585883 (1)
    nitrilotriacetic acid 74.8 1 10913124 (1)
    phosphoinositide 57.9 1 10983985 (1)
    phosphatidylinositol 53.6 3 9742223 (1), 11445584 (1)
    gtp 39.1 5 10480924 (3)
    inositol 36.8 1 9742223 (1)
    lipid 21.8 1 9742223 (1)
    adp 21.7 1 9707577 (1)
    glucose 0 1 9832437 (1)

    Search CenterWatch for drugs/clinical trials and news about CYTH3 / CYH3 

    Transcripts
    for CYTH3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYTH3 gene: 
    NM_004227.3  

    Unigene Cluster for CYTH3:

    Cytohesin 3
    Hs.487479  [show with all ESTs]
    Unigene Representative Sequence: BC028717
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350796(uc011jws.2 uc003spt.3) ENST00000465320 ENST00000495176
    ENST00000461891 ENST00000488964 ENST00000466543 ENST00000491641 ENST00000478541
    ENST00000481329 ENST00000482460 ENST00000396741

    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH3 (see all 64):
    hsa-miR-323-3p hsa-miR-374a hsa-miR-508-5p hsa-miR-200b hsa-miR-601 hsa-let-7i hsa-miR-3922-3p hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AJ005197.1 AJ223957.1 AK023609.1 AK295163.1 AK313728.1 BC008191.1 BC028717.1 

    12 DOTS entries:

    DT.115494  DT.91751503  DT.121045961  DT.121045975  DT.100754860  DT.40208443  DT.91937315  DT.92000647 
    DT.121045941  DT.121046022  DT.92009308  DT.100754859 

    24/184 AceView cDNA sequences (see all 184):

    BQ771707 CA422558 AI218213 CB529534 AI127947 BX097016 AW043741 AI079981 
    AI339389 BI828541 BQ015085 BQ477486 AA927126 BM670382 CA430257 BC028717 
    CN483229 T33202 CA396806 BM844079 BM905668 BM712092 BG571309 AI870712 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                      -     -                 -     -                       -                 -                                             
    SP2:                                                              -     -                       -           -     -     -     -     -     -     -               
    SP3:                                                                                                              -                                             
    SP4:                                                                                                              -     -     -                                 
    SP5:                                                                                                                    -     -                                 


    ECgene alternative splicing isoforms for CYTH3

    Expression
    for CYTH3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYTH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTGTTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CYTH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYTH3

    SOURCE GeneReport for Unigene cluster: Hs.487479

    UniProtKB/Swiss-Prot: CYH3_HUMAN, O43739
    Tissue specificity: Almost absent from liver, thymus and peripheral blood lymphocytes

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    In Situ
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    Orthologs
    for CYTH3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CYTH3 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CYTH31 cytohesin 3 80.1(n)
    96.73(a)    		   416626  XM_414927.3  XP_414927.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CYTH36
    		 --
    		 94(a)
    		 1 ↔ 1
    		 GL343507.1(157781-178368)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005374481 cytohesin-3-like 78.44(n)
    93.81(a)    		   100537448  XM_003198177.1  XP_003198225.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta step6
    		 steppke
    		 34(a)
    		 possible ortholog
    		 2L(21740041-21757466)
    worm
    (Caenorhabditis elegans)    		 Secernentea grp-11 Protein GRP-1 49.51(n)
    43.4(a)    		   176140  NM_066363.2  NP_498764.1 


    ENSEMBL Gene Tree for CYTH3 (if available)
    TreeFam Gene Tree for CYTH3 (if available) 

    Paralogs
    for CYTH3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYTH3 gene
    PSD32  GBF12  IQSEC32  CYTH22  ARFGEF22  PSD42  ARFGEF12  IQSEC12  
    PSD22  PSD2  IQSEC22  CYTH42  CYTH12  FBXO82  
    9 SIMAP similar genes for CYTH3 using alignment to 3 protein entries:     CYH3_HUMAN (see all proteins):
    PSCD2L    CYTH1    CYTH2    CYTH4    FLJ00017    ARFGEF2
    ARFGEF1    FAM109A    IQSEC1

    CYTH3 for paralogs           About GeneDecksing



    Genomic Variants
    for CYTH3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2175 NCBI SNPs in CYTH3 are shown (see all 2175)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1448572841,2
    		--6201019(+) GTGGGA/GAAAAC 2 -- ut31 ds50010--------
    rs1386551511,2
    		--6201189(+) CAGCAA/CATCAC 2 -- ds5001 ut310--------
    rs1492409941,2
    		--6201299(+) CTGCCA/GAAGTC 2 -- int1 ds50010--------
    rs1480070541,2
    		--6201420(+) ACAATA/GCATGT 2 -- ut31 int10--------
    rs1887096401,2
    		--6201467(+) CTGACA/GGCCAT 2 -- int1 ut310--------
    rs1811951601,2
    		--6201623(+) GCAAAA/TAGAAA 2 -- ut31 int10--------
    rs1853023771,2
    		--6201775(+) ATCTAC/TAAATA 1 -- ut310--------
    rs1434788051,2
    		--6201844(+) AGACAA/CAAAGT 1 -- ut310--------
    rs1400544281,2
    		--6201955(+) CCCCGC/TGGGGC 1 -- ut310--------
    rs1882122821,2
    		--6201985(+) CCTCTC/GTCTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CYTH3 (6201407 - 6312275 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CYTH3
         1 CNV: 10174
         1 Indel: 63143
         1 Inversion: 37290

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CYTH3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYTH3 for disorders           About GeneDecksing

    OMIM gene information: 605081    OMIM disorders: --

    3 diseases for CYTH3:    About MalaCards
    breast cancer    thyroiditis    hepatitis

    1 Novoseek disease relationship for CYTH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 11059789 (3)


    Export disorders for CYTH3 gene to outside databases

    Publications
    for CYTH3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYTH3 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with CYTH3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. (PubMed id 9742223)1, 2, 9 Venkateswarlu K.... Cullen P.J. (1998)
    2. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. (PubMed id 9707577)1, 2, 9 Franco M....Chavrier P. (1998)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I....Munro S. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    6. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2 Ogasawara M.... Vaughan M. (2000)
    7. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. (PubMed id 9072969)1, 3 Klarlund J.K....Czech M.P. (1997)
    8. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. (PubMed id 11445584)1, 9 Klarlund J.K....Czech M.P. (2001)
    9. Phosphoinositide specificity determines which cytohesi ns regulate b1 integrin recycling. (PubMed id 22454518)1 Oh S.J. and Santy L.C. (2012)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for CYTH3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYTH3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9265 HGNC: 9504 AceView: PSCD3 Ensembl:ENSG00000008256 euGenes: HUgn9265
    ECgene: CYTH3 H-InvDB: CYTH3

    Other Databases showing CYTH3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYTH3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYTH3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CYTH3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYTH3 gene:
    Search GeneIP for patents involving CYTH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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