CYTH2 Gene
protein-coding GIFtS: 55
GCID: GC19P048972
|
|
cytohesin 2(Previous names: pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2),...)
(Previous symbols: PSCD2L, PSCD2)
| |
Aliases
for CYTH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytohesin 21 2 | | ARF Nucleotide-Binding Site Opener2 3 | | ARNO1 2 3 5 | | PH, SEC7 And Coiled-Coil Domain-Containing Protein 22 3 | | PSCD21 2 3 5 | | Pleckstrin Homology, Sec7 And Coiled-Coil Domains 21 | | PSCD2L1 2 3 5 | | CTS182 | | CTS18.11 2 | | SEC7L2 | | Sec7p-L1 2 | | Cytohesin-21 | | Sec7p-Like1 | | Pleckstrin Homology, Sec7 And Coiled-Coil Domains 2 (Cytohesin-2)2 | | Pleckstrin Homology, Sec7 And Coiled/Coil Domains 2 (Cytohesin-2)1 2 | | Protein ARNO3 | | ARF Exchange Factor2 3 | | |
Export aliases for CYTH2 gene to outside databasesPrevious GC identifers: GC19P053667 GC19P045352 |
Summaries
for CYTH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYTH2:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structuralorganization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrinhomology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain containsguanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsiblefor association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sortingand membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83%homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Aug 2008)
UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418Function: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 andARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, inassociation with ARL4 proteins, recruits ARF6 to the plasma membrane
Gene Wiki entry for CYTH2 (PSCD2)
|
Genomic Views
for CYTH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYTH2 gene promoter:
Pax-2 Pax-2a NF-kappaB Tal-1beta AREB6 Egr-2 PPAR-gamma1 PPAR-gamma2 ITF-2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYTH2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32CYTH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P048972: view genomic region
(about GC identifiers)
Start:
|
48,972,289 bp from pter |
End:
|
48,985,571 bp from pter |
Size:
|
13,283 bases |
Orientation:
|
plus strand |
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Proteins
for CYTH2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418 (See
protein sequence)Recommended Name: Cytohesin-2 Size: 400 amino acids; 46546 Da
Subunit: Heteromer. Composed of GRASP, CYTH2 and at least one GRM1 (By similarity). Interacts with ARRB1. Interactswith ARL4D; the interaction is direct
Subcellular location: Cell membrane. Cytoplasm. Note=Both isoform 1 and isoform 2 are recruited to the cell membranethrough its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting toplasma membrane
5 PDB 3D structures from  and Proteopedia  for CYTH2:1PBV (3D)
1R8M (3D)
1R8Q (3D)
1R8S (3D)
1S9D (3D)
Secondary accessions: A8K8P0 Q8IXY9 Q92958Alternative splicing: 2 isoforms: Q99418-1 Q99418-2 Explore the universe of human proteins at neXtProt for CYTH2: NX_Q99418
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99418
CYTH2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004219.3 NP_059431.1
ENSEMBL proteins: ENSP00000408236 ENSP00000375753 ENSP00000314566 ENSP00000391648
Human Recombinant Protein Products for CYTH2:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CYTH2 for ontologies About GeneDecksing
CYTH2 Antibody Products:
Assay Products for CYTH2: |
Protein
Domains /
Families
for CYTH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYTH2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99418ProtoNet protein and cluster: Q99418 2 Blocks protein families: IPB000904 SEC7-like domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418Domain: The PH domain is necessary and sufficient for plasma membrane relocalizationSimilarity: Contains 1 PH domainSimilarity: Contains 1 SEC7 domain |
Function
for CYTH2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CYH2_HUMAN, Q99418Function: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 andARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, inassociation with ARL4 proteins, recruits ARF6 to the plasma membrane Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity |
IBA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0005543 | phospholipid binding |
IEA | -- |
CYTH2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CYTH2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CYTH2 (NM_017457) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYTH2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH2 |
|
Pathways & Interactions
for CYTH2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Arf6 signaling events | | | 2 | Class I PI3K signaling events | | | 3 | Arf1 pathway | |
3  BioSystems Pathways for CYTH2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYTH2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/26 Interacting proteins for CYTH2 (Q994181, 2, 3 ENSP000004082364) via UniProtKB, MINT, STRING, and/or I2D (see all 26)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ADORA2A | P292741, 3, ENSP000003366304 | EBI-1965579,EBI-2902702 I2D:
score=3 STRING: ENSP00000336630 | | ARF1 | P840771, 3, ENSP000002721024 | EBI-1965579,EBI-447171 I2D:
score=3 STRING: ENSP00000272102 | | MAPK6 | Q166592, 3 | MINT-8260922 I2D:
score=2 | | SFN | P319472, 3 | MINT-3976039 I2D:
score=2 | | ATP6V0A2 | Q9Y4871, 3, ENSP000003322474 | EBI-1965579,EBI-988630 I2D:
score=4 STRING: ENSP00000332247 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CYTH2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYTH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYTH2 for compounds About GeneDecksing
 Browse Tocris compounds for CYTH2
1 HMDB Compound for CYTH2 About this table
5 DrugBank Compounds for CYTH2 About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| D-Myo-Inositol-1,4,5-Triphosphate | -- | -- | target | -- | 17139284 17016423 10592235 | | Inositol 1,3,4,5-Tetrakisphosphate | -- | -- | target | -- | 17139284 17016423 10592235 | | 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE | -- | -- | target | -- | 10592235 | | Formic Acid | Aminic acid (see all 5) | 64-18-6 | target | -- | -- | | S,S-(2-Hydroxyethyl)Thiocysteine | -- | -- | target | -- | -- |
7 Novoseek chemical compound relationships for CYTH2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| grp-1 |
96.9 |
11 |
16219693 (3), 20223830 (2), 10913124 (2), 15359279 (1) (see all 7) |
| nitrilotriacetic acid |
74.6 |
3 |
11927660 (2), 10913124 (1) |
| gtp |
64.2 |
7 |
10734117 (1), 11927660 (1), 9788883 (1), 10608818 (1) (see all 6) |
| hampshire |
63.6 |
3 |
11927660 (2), 10913124 (1) |
| phosphatidylinositol |
40.8 |
5 |
11927660 (2), 15359279 (1) |
| lipid |
11.2 |
2 |
10531036 (1), 10734117 (1) |
| serine |
9.65 |
3 |
10531036 (1), 12438709 (1) |
Search CenterWatch for drugs/clinical trials and news about CYTH2 / CYH2
|
Transcripts
for CYTH2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYTH2 gene (2 alternative transcripts): NM_004228.6 NM_017457.5 Unigene Cluster for CYTH2: Cytohesin 2 Hs.144011 [show with all ESTs]Unigene Representative Sequence: NM_01745710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452733(uc010xzr.1) ENST00000460595 ENST00000391881 ENST00000493260
ENST00000462117 ENST00000474049 ENST00000325139 ENST00000467412 ENST00000474209
ENST00000427476(uc002pjj.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CYTH2 (NM_017457) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYTH2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH2 |
Additional cDNA sequence: AF318380.1 AK292405.1 AK299590.1 BC004361.1 BC012771.2 BC035646.1 BC036615.1 BC038713.1 BC042153.1 BC047631.1 U59752.1 U70728.1 X99753.1 19 DOTS entries: DT.308230 DT.100845723 DT.100719894 DT.91651388 DT.100698463 DT.217717 DT.403721 DT.85105524 DT.95374399 DT.97791607 DT.100845736 DT.91855472 DT.95112227 DT.100747252 DT.100844551 DT.100845734 DT.217719 DT.40107492 DT.95374396 24/265 AceView cDNA sequences (see all 265): CR621270 CR591823 BC004361 BM553464 NM_017457 AF337808 AI082799 BQ640151 AA349001 BQ928509 BU158112 BM423457 NM_004228 CR621404 BU849942 BC002440 CA417008 BX355901 BQ639264 CR610853 AW300643 BC036281 CR596472 CR623405
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYTH2
|
Expression
for CYTH2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYTH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTACCGGA
About this image
See CYTH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYTH2
SOURCE GeneReport for Unigene cluster: Hs.144011
UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for CYTH2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYTH2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYTH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH2 |
Orthologs
for CYTH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CYTH2 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CYTH26 |
-- |
93(a) |
1 ↔ 1 |
GL343329.1(749004-760568) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.104982 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.78(n) |
|
BX846623.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cyth21 |
cytohesin 2 |
77.61(n)
88.8(a) |
|
569358 XM_692738.5 XP_697830.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
step6 |
steppke |
34(a) |
possible ortholog |
2L(21740041-21757466) |
worm
(Caenorhabditis elegans) |
Secernentea |
grp-16 |
GTP exchange factor for ARFs 1 |
36(a) |
1 → many |
III(8085638-8088382) |
ENSEMBL Gene Tree for CYTH2 (if available)
TreeFam Gene Tree for CYTH2 (if available) |
Paralogs
for CYTH2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYTH2 gene
- PSD32 GBF12 CYTH32 IQSEC32 ARFGEF22 PSD42 ARFGEF12 IQSEC12
- PSD22 PSD2 IQSEC22 CYTH42 CYTH12 FBXO82
10 SIMAP similar genes for CYTH2 using alignment to 5 protein entries: CYH2_HUMAN (see all proteins):PSCD2L CYTH3 CYTH1 FLJ00017 CYTH4 ARFGEF2
ARFGEF1 IQSEC1 IQSEC3 FAM109A
CYTH2 for paralogs About GeneDecksing
|
Genomic Variants
for CYTH2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYTH2 (48972289 - 48985571 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYTH2
1 CNV: 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYTH2 |
|
Disorders
/ Diseases
for CYTH2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYTH2 for disorders About GeneDecksing
OMIM gene information: 602488
OMIM disorders: --
3  diseases for CYTH2: About MalaCardspeutz-jeghers syndrome fibrosis neuronitis
Export disorders for CYTH2 gene to outside databases
|
Publications
for CYTH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYTH2 gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with CYTH2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human exchange factor for ARF contains Sec7- and pleckstrin- homology domains. (PubMed id 8945478)1, 2, 3, 9 Chardin P.... Chabre M. (1996)
- Structure of the Sec7 domain of the Arf exchange factor ARNO. (PubMed id 9510256)1, 2, 9 Cherfils J.... Chardin P. (1998)
- The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I....Munro S. (2007)
- Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the dow nstream activation of Arf6. (PubMed id 20525696)1, 3 Torii T....Tanoue A. (2010)
- The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network. (PubMed id 17623778)1, 2 Bouschet T....Henley J.M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. (PubMed id 14654833)1, 2 Renault L.... Cherfils J. (2003)
- ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. (PubMed id 9417041)1, 2 Frank S.F.... Casanova J.E. (1998)
- Structure of the guanine nucleotide exchange factor Sec7 domain of human ARNO and analysis of the interaction with ARF GTPase. (PubMed id 9476900)1, 2 Mossessova E.... Goldberg J. (1998)
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External Searches for CYTH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CYTH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CYTH2 gene
(According to HUGE)
About This Section
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Specialized Databases showing CYTH2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CYTH2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CYTH2 gene:
Search GeneIP for patents involving CYTH2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYTH2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for CYTH2 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTH2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYTH2 | | | OriGene Protein Over-expression Lysate for CYTH2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CYTH2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CYTH2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYTH2 | | OriGene Custom Protein Services for CYTH2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYTH2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYTH2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYTH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYTH2 |
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| | | | Search Tocris compounds for CYTH2 |
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 | | | CYTH2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH2 |
|  |  |  |  | | | | ThermoFisher Antibody for CYTH2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH2 |
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