Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CYTH2 Gene

protein-coding   GIFtS: 57
GCID: GC19P048972

Cytohesin 2

(Previous names: pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2),...)
(Previous symbols: PSCD2L, PSCD2)
  Search for CYTH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytohesin 21 2     CTC-273B12.82
PSCD21 2 3 5     CTS182
PSCD2L1 2 3 5     CTS18.12
ARNO2 3 5     SEC7L2
Pleckstrin Homology, Sec7 And Coiled/Coil Domains 2 (Cytohesin-2)1 2     Sec7p-L2
ARF Exchange Factor2 3     Sec7p-like2
ARF Nucleotide-Binding Site Opener2 3     cytohesin-22
PH, SEC7 And Coiled-Coil Domain-Containing Protein 22 3     Pleckstrin Homology, Sec7 And Coiled-Coil Domains 2 (Cytohesin-2)2
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 21     Protein ARNO3

External Ids:    HGNC: 95021   Entrez Gene: 92662   Ensembl: ENSG000001054437   OMIM: 6024885   UniProtKB: Q994183   

Export aliases for CYTH2 gene to outside databases

Previous GC identifers: GC19P053667 GC19P045352


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CYTH2 Gene:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin
homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains
guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of
protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and
ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for CYTH2 Gene:
CYTH2 (cytohesin 2) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418
Function: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3
and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in
association with ARL4 proteins, recruits ARF6 to the plasma membrane

Gene Wiki entry for CYTH2 (PSCD2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYTH2 gene promoter:
         Pax-2   Pax-2a   NF-kappaB   Tal-1beta   AREB6   Egr-2   PPAR-gamma1   PPAR-gamma2   ITF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYTH2 promoter sequence
   Search Chromatin IP Primers for CYTH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYTH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CYTH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048972:  view genomic region     (about GC identifiers)

Start:
48,972,289 bp from pter      End:
48,985,571 bp from pter
Size:
13,283 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418 (See protein sequence)
Recommended Name: Cytohesin-2  
Size: 400 amino acids; 46546 Da
Subunit: Heteromer. Composed of GRASP, CYTH2 and at least one GRM1 (By similarity). Interacts with ARRB1.
Interacts with ARL4D; the interaction is direct
Selected PDB 3D structures from and Proteopedia for CYTH2 (see all 10):
1PBV (3D)        1R8M (3D)        1R8Q (3D)        1R8S (3D)        1S9D (3D)        4JMI (3D)    
Secondary accessions: A8K8P0 Q8IXY9 Q92958
Alternative splicing: 2 isoforms:  Q99418-1   Q99418-2   

Explore the universe of human proteins at neXtProt for CYTH2: NX_Q99418

Explore proteomics data for CYTH2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys78
  • Modification sites at PhosphoSitePlus

  • See CYTH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004219.3  NP_059431.1  

    ENSEMBL proteins: 
     ENSP00000408236   ENSP00000375753   ENSP00000314566   ENSP00000472602   ENSP00000391648  

    CYTH2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CYTH2
    OriGene Protein Over-expression Lysate for CYTH2
    OriGene MassSpec for CYTH2
    OriGene Custom Protein Services for CYTH2
    GenScript Custom Purified and Recombinant Proteins Services for CYTH2
    Novus Biologicals CYTH2 Proteins
    Novus Biologicals CYTH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CYTH2
    Cloud-Clone Corp. Proteins for CYTH2

     
    Search eBioscience for Proteins for CYTH2 

    CYTH2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CYTH2
    OriGene Custom Antibody Services for CYTH2
    Novus Biologicals CYTH2 Antibodies
    Abcam antibodies for CYTH2
    Cloud-Clone Corp. Antibodies for CYTH2
    ThermoFisher Antibody for CYTH2
    LSBio Antibodies in human, mouse, rat for CYTH2

    CYTH2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYTH2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYTH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYTH2
    Cloud-Clone Corp. CLIAs for CYTH2
    Search eBioscience for ELISAs for CYTH2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 Sec7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7_dom

    Graphical View of Domain Structure for InterPro Entry Q99418

    ProtoNet protein and cluster: Q99418

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418
    Domain: Binds via its PH domain to the inositol head group of phosphatidylinositol 1,4,5-trisphosphate. The PH
    domain is necessary and sufficient for plasma membrane relocalization
    Domain: Autoinhibited by its C-terminal basic region (By similarity)
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    Find genes that share domains with CYTH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH2_HUMAN, Q99418
    Function: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3
    and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in
    association with ARL4 proteins, recruits ARF6 to the plasma membrane

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity ISS--
    GO:0005515protein binding IPI10198630
    GO:0008289lipid binding IEA--
    GO:0070679inositol 1,4,5 trisphosphate binding ISS--
         
    Find genes that share ontologies with CYTH2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CYTH2:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYTH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYTH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYTH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYTH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYTH2:
    hsa-mir-26b-5p (MIRT030082), hsa-mir-191-5p (MIRT045806)

    Block miRNA regulation of human, mouse, rat CYTH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYTH2 (see all 18):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-1908 hsa-miR-486-3p hsa-miR-28-5p hsa-miR-569 hsa-miR-3184
    SwitchGear 3'UTR luciferase reporter plasmidCYTH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYTH2
    Predesigned siRNA for gene silencing in human, mouse, rat CYTH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYTH2

    Clone
    Products:
         
    OriGene clones in human, mouse for CYTH2 (see all 12)
    OriGene ORF clones in mouse, rat for CYTH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CYTH2 (NM_017457)
    Sino Biological Human cDNA Clone for CYTH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYTH2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CYTH2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CYH2_HUMAN, Q99418: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Both isoform 1 and isoform 2 are
    recruited to the cell membrane through their association with ARL4A, ARL4C and ARL4D. They require also
    interaction with phosphoinositides for targeting to the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    golgi apparatus3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17398095
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IDA17398095
    GO:0016020membrane TAS9417041

    Find genes that share ontologies with CYTH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CYTH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I PI3K signaling events
    Class I PI3K signaling events
    2Arf6 signaling events
    Arf6 signaling events
    3Arf1 pathway
    Arf1 pathway


    3 BioSystems Pathways for CYTH2
        Arf1 pathway
    Class I PI3K signaling events
    Arf6 signaling events



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYTH2
    Interactions:

        GeneGlobe Interaction Network for CYTH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYTH2 (Q994181, 2, 3 ENSP000004082364) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADORA2AP292741, 3, ENSP000003366304EBI-448974,EBI-2902702 I2D: score=3 STRING: ENSP00000336630
    ARF1P840771, 3, ENSP000002721024EBI-448974,EBI-447171 I2D: score=3 STRING: ENSP00000272102
    MAPK6Q166592, 3MINT-8260922 I2D: score=2 
    SFNP319472, 3MINT-3976039 I2D: score=2 
    ATP6V0A2Q9Y4871, 3, ENSP000003322474EBI-448974,EBI-988630 I2D: score=4 STRING: ENSP00000332247
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis TAS9417041
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030036actin cytoskeleton organization TAS9417041
    GO:0030155regulation of cell adhesion IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--

    Find genes that share ontologies with CYTH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYTH2 (CYH2)

    1 HMDB Compound for CYTH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 DrugBank Compounds for CYTH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Myo-Inositol-1,4,5-Triphosphate-- --target--17139284 17016423 10592235
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423 10592235
    1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE-- --target--10592235
    Formic AcidAminic acid (see all 5)64-18-6target----
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target----

    7 Novoseek inferred chemical compound relationships for CYTH2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 96.9 11 16219693 (3), 20223830 (2), 10913124 (2), 15359279 (1) (see all 7)
    nitrilotriacetic acid 74.6 3 11927660 (2), 10913124 (1)
    gtp 64.2 7 10734117 (1), 11927660 (1), 9788883 (1), 10608818 (1) (see all 6)
    hampshire 63.6 3 11927660 (2), 10913124 (1)
    phosphatidylinositol 40.8 5 11927660 (2), 15359279 (1)
    lipid 11.2 2 10531036 (1), 10734117 (1)
    serine 9.65 3 10531036 (1), 12438709 (1)



    Find genes that share compounds with CYTH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CYTH2 gene (2 alternative transcripts): 
    NM_004228.6  NM_017457.5  

    Unigene Cluster for CYTH2:

    Cytohesin 2
    Hs.144011  [show with all ESTs]
    Unigene Representative Sequence: NM_017457
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452733(uc010xzr.1) ENST00000460595 ENST00000391881 ENST00000493260
    ENST00000462117 ENST00000474049 ENST00000325139 ENST00000595765 ENST00000474209
    ENST00000467412 ENST00000427476(uc002pjj.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYTH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYTH2 (see all 18):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-1908 hsa-miR-486-3p hsa-miR-28-5p hsa-miR-569 hsa-miR-3184
    SwitchGear 3'UTR luciferase reporter plasmidCYTH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYTH2
    Predesigned siRNA for gene silencing in human, mouse, rat CYTH2
    Clone
    Products:
         
    OriGene clones in human, mouse for CYTH2 (see all 12)
    OriGene ORF clones in mouse, rat for CYTH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CYTH2 (NM_017457)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYTH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYTH2
    OriGene qSTAR qPCR primer pairs in human, mouse for CYTH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYTH2
      QuantiTect SYBR Green Assays in human, mouse, rat CYTH2
      QuantiFast Probe-based Assays in human, mouse, rat CYTH2

    Additional mRNA sequence: 

    AF318380.1 AK292405.1 AK299590.1 BC004361.1 BC012771.2 BC035646.1 BC036615.1 BC038713.1 
    BC042153.1 BC047631.1 U59752.1 U70728.1 X99753.1 

    21 DOTS entries:

    DT.308230  DT.100845723  DT.100719894  DT.91651388  DT.100698463  DT.217717  DT.100019103  DT.403721 
    DT.85105524  DT.95374399  DT.97791607  DT.100845736  DT.91855472  DT.95112227  DT.100747252  DT.100844551 
    DT.100845734  DT.217719  DT.40107492  DT.426097  DT.95374396 

    Selected AceView cDNA sequences (see all 265):

    BM684176 BQ642325 CR591768 BQ928509 CA417008 CB109265 AA678452 BX416164 
    BM695721 BQ721999 AI990799 BC004361 CR608279 CB142128 CR621270 BX355901 
    CR616768 BM467438 CK904655 BM458317 BU196477 BQ640151 BM554991 NM_013348 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYTH2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                    -                 -           -     -           -     -                                             
    SP2:                    -                 -           -     -           -                                                   
    SP3:                                      -           -     -           -     -                                             
    SP4:                    -           -     -           -     -                                                               
    SP5:                    -           -     -                                                                                 


    ECgene alternative splicing isoforms for CYTH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CYTH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTACCGGA
    CYTH2 Expression
    About this image

    CYTH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYTH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144011

    UniProtKB/Swiss-Prot: CYH2_HUMAN, Q99418
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for CYTH2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYTH2
    OriGene qSTAR qPCR primer pairs in human, mouse for CYTH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYTH2
    QuantiTect SYBR Green Assays in human, mouse, rat CYTH2
    QuantiFast Probe-based Assays in human, mouse, rat CYTH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth21 , 5 cytohesin 21, 5 90.83(n)1
    99.25(a)1
      7 (29.52 cM)5
    191581  NM_011181.31  NP_035311.11 
     458066395 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    GL343329.1(744887-765238)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.104982 Xenopus laevis transcribed sequence with moderate similarity more 77.78(n)    BX846623.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-283b15.41 si:dkey-283b15.4 77.17(n)
    88(a)
      569358  XM_692738.6  XP_697830.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta step6
    steppke
    34(a)
    1 → many
    2L(21740041-21757466)
    worm
    (Caenorhabditis elegans)
    Secernentea grp-16
    Protein GRP-1 (grp-1) mRNA, complete cds
    39(a)
    1 → many
    III(8085705-8088448) WBGene00001743
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    6(a)
    1 → many
    IV(796193-802222) YDR170C


    ENSEMBL Gene Tree for CYTH2 (if available)
    TreeFam Gene Tree for CYTH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CYTH2 gene
    CYTH32  IQSEC32  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  IQSEC22  CYTH42  
    CYTH12  FBXO82  
    11 SIMAP similar genes for CYTH2 using alignment to 5 protein entries:     CYH2_HUMAN (see all proteins):
    PSCD2L    CYTH3    CYTH1    CYTH4    FLJ00017    ARFGEF2
    ARFGEF1    IQSEC1    IQSEC3    FAM109A    PSD3

    Find genes that share paralogs with CYTH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CYTH2 (see all 453)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873029531,2
    --48970474(+) ATCTCC/TCTTTA 2 -- us2k10--------
    rs1916913221,2
    --48970511(+) GGATGA/GGATTA 2 -- us2k10--------
    rs1416633961,2
    --48970554(+) TGGGGC/TAGGTA 2 -- us2k10--------
    rs1505319851,2
    --48970580(+) GAAACA/GCAGGG 2 -- us2k10--------
    rs1385202091,2
    --48970591(+) TTGGGA/GAAGGA 2 -- us2k10--------
    rs81051111,2
    C,F--48970627(+) GGAGGG/CGGTTT 2 -- us2k1 trp32Minor allele frequency- C:0.21CSA WA 119
    rs1815740861,2
    C--48970659(+) CAGGGC/TAGCCC 2 -- us2k10--------
    rs1852740101,2
    --48970753(+) GACAGC/TTTAAC 2 -- us2k10--------
    rs124624021,2
    C,F,H--48970812(+) AAATGA/GGGACG 2 -- us2k12Minor allele frequency- G:0.03NA 98
    rs1900985541,2
    --48971014(+) CTCACA/GCCTAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYTH2 (48972289 - 48985571 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CYTH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658088CNV Deletion23128226
    nsv828572CNV Loss20364138
    nsv518578CNV Loss19592680
    nsv912222CNV Loss21882294
    nsv912223CNV Loss21882294
    nsv912219CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYTH2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYTH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602488    OMIM disorders: --


    Find genes that share disorders with CYTH2           About GenesLikeMe


    Export disorders for CYTH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CYTH2 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with CYTH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human exchange factor for ARF contains Sec7- and pleckstrin- homology domains. (PubMed id 8945478)1, 2, 3, 9 Chardin P.... Chabre M. (Nature 1996)
    2. Structure of the Sec7 domain of the Arf exchange factor ARNO. (PubMed id 9510256)1, 2, 9 Cherfils J.... Chardin P. (Nature 1998)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I.... Munro S. (Curr. Biol. 2007)
    4. Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6. (PubMed id 20525696)1, 3 Torii T....Tanoue A. (J. Biol. Chem. 2010)
    5. The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network. (PubMed id 17623778)1, 2 Bouschet T.... Henley J.M. (J. Cell Sci. 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. (PubMed id 14654833)1, 2 Renault L.... Cherfils J. (Nature 2003)
    9. ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. (PubMed id 9417041)1, 2 Frank S.F.... Casanova J.E. (J. Biol. Chem. 1998)
    10. Structure of the guanine nucleotide exchange factor Sec7 domain of human ARNO and analysis of the interaction with ARF GTPase. (PubMed id 9476900)1, 2 Mossessova E.... Goldberg J. (Cell 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9266 HGNC: 9502 AceView: PSCD2andKCNJ14andGRWD1 Ensembl:ENSG00000105443 euGenes: HUgn9266
    ECgene: CYTH2 H-InvDB: CYTH2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CYTH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CYTH2 gene:
    Search GeneIP for patents involving CYTH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CYTH2   OriGene RNAi products in human, mouse, rat for CYTH2  
     OriGene qPCR primer pairs and template standards for CYTH2   OriGene Protein Over-expression Lysate for CYTH2  
     OriGene MassSpec something-or-other for CYTH2   OriGene clones in human, mouse for CYTH2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYTH2   OriGene Purified Protein for CYTH2  
     OriGene ORF clones in mouse, rat for CYTH2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYTH2   OriGene Custom Protein Services for CYTH2  

     
     
     Block miRNA regulation of human, mouse, rat CYTH2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CYTH2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYTH2 Predesigned siRNA for gene silencing in human, mouse, rat CYTH2
     QuantiFast Probe-based Assays in human, mouse, rat CYTH2 QuantiTect SYBR Green Assays in human, mouse, rat CYTH2
     Custom PCR Arrays for CYTH2 Search Chromatin IP Primers for CYTH2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYTH2  GeneGlobe Interaction Network for CYTH2
     Regulatory tfbs in CYTH2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CYTH2 GenScript cDNA clones with any tag delivered in your preferred vector for CYTH2
     GenScript Custom Assay Services for CYTH2 GenScript Custom overexpressing Cell Line Services for CYTH2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CYTH2 (CYH2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CYTH2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CYTH2 antibodies
     CYTH2 proteins
     CYTH2 lysates
     Antibodies for CYTH2
     See all of Abcam's Antibodies, Kits and Proteins for CYTH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CYTH2
     Proteins for CYTH2
     Antibodies for CYTH2
     ELISAs for CYTH2
     CLIAs for CYTH2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CYTH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH2
     SwitchGear 3'UTR luciferase reporter plasmids for CYTH2
     SwitchGear Promoter luciferase reporter plasmids for CYTH2
     ThermoFisher Antibody for CYTH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYTH2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYTH2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYTH2
     LSBio Antibodies in human, mouse, rat for CYTH2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CYTH2
      Search eBioscience for proteins for CYTH2
      Search eBioscience for elisas for CYTH2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYTH2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4