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CYTH1 Gene

protein-coding   GIFtS: 59
GCID: GC17M076670

Cytohesin 1

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains 1)
(Previous symbol: PSCD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytohesin 11 2     SEC72 5
PSCD11 2 3     B2-12
D17S811E2 3 5     CYTOHESIN-12
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 11 2     Cytoadhesin 12
PH, SEC7 And Coiled-Coil Domain-Containing Protein 12 3     cytohesin-12
SEC7 Homolog B2-12 3     Homolog Of Secretory Protein SEC72

External Ids:    HGNC: 95011   Entrez Gene: 92672   Ensembl: ENSG000001086697   OMIM: 1821155   UniProtKB: Q154383   
ORGUL members:         

Export aliases for CYTH1 gene to outside databases

Previous GC identifers: GC17M074182 GC17M072092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYTH1 Gene:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin
homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains
guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of
protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells,
and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83%
homologous to that of CYTH2. (provided by RefSeq, Aug 2008)

GeneCards Summary for CYTH1 Gene:
CYTH1 (cytohesin 1) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through
replacement of GDP with GTP

Gene Wiki entry for CYTH1 (PSCD1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYTH1 gene promoter:
         AML1a   AP-1   ATF-2   MyoD   AP-4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYTH1 promoter sequence
   Search Chromatin IP Primers for CYTH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYTH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

CYTH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076670:  view genomic region     (about GC identifiers)

Start:
76,670,130 bp from pter      End:
76,778,379 bp from pter
Size:
108,250 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438 (See protein sequence)
Recommended Name: Cytohesin-1  
Size: 398 amino acids; 46413 Da
Subunit: Interacts with TRIM23 and CYTIP
2 PDB 3D structures from and Proteopedia for CYTH1:
1BC9 (3D)        4A4P (3D)    
Secondary accessions: A6NFW7 Q9P123 Q9P124
Alternative splicing: 2 isoforms:  Q15438-1   Q15438-2   

Explore the universe of human proteins at neXtProt for CYTH1: NX_Q15438

Explore proteomics data for CYTH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYTH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004753.1  NP_059430.2  

    ENSEMBL proteins: 
     ENSP00000465940   ENSP00000466512   ENSP00000465665   ENSP00000389095   ENSP00000465252  
     ENSP00000465945   ENSP00000467052   ENSP00000468433   ENSP00000465530   ENSP00000466949  
     ENSP00000354398  

    CYTH1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CYTH1

     
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    antibodies-online proteins for CYTH1 (5 products) 

     
    antibodies-online peptides for CYTH1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 Sec7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7_dom

    Graphical View of Domain Structure for InterPro Entry Q15438

    ProtoNet protein and cluster: Q15438

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438
    Domain: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate (By
    similarity)
    Domain: Autoinhibited by its C-terminal basic region (By similarity)
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    Find genes that share domains with CYTH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH1_HUMAN, Q15438
    Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through
    replacement of GDP with GTP

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IDA10652308
    GO:0005515protein binding IPI11867758
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with CYTH1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cyth1):
     nervous system 

    Find genes that share phenotypes with CYTH1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYTH1

    miRNA
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    miRTarBase miRNAs that target CYTH1:
    hsa-mir-34a-5p (MIRT047342), hsa-mir-193b-3p (MIRT016372), hsa-mir-335-5p (MIRT017284), hsa-mir-26b-5p (MIRT029189)

    Block miRNA regulation of human, mouse, rat CYTH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYTH1 (see all 58):
    hsa-miR-429 hsa-miR-4328 hsa-miR-624 hsa-miR-138-2* hsa-miR-764 hsa-miR-1304 hsa-miR-629* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidCYTH1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYH1_HUMAN, Q15438: Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    golgi apparatus3
    endoplasmic reticulum2
    endosome2
    nucleus2
    vacuole2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12606567
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane IDA12606567
    GO:0005923tight junction IEA--

    Find genes that share ontologies with CYTH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYTH1 About    
    See pathways by source

    SuperPathContained pathways About
    1Development Angiotensin activation of ERK
    Cell adhesion Integrin inside out signaling0.44
    2Immune response Role of DAP12 receptors in NK cells
    Immune response CD16 signaling in NK cells0.33
    3Class I PI3K signaling events
    Class I PI3K signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CYTH1
        Cell adhesion Integrin inside-out signaling
    Immune response CD16 signaling in NK cells

    1 BioSystems Pathway for CYTH1
        Class I PI3K signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYTH1
    Interactions:

        Search GeneGlobe Interaction Network for CYTH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CYTH1 (Q154381, 2, 3 ENSP000003543984) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051072, 3, ENSP000003032424MINT-4652150 I2D: score=5 STRING: ENSP00000303242
    CYTIPO607591, 3, ENSP000002641924EBI-997830,EBI-997814 I2D: score=4 STRING: ENSP00000264192
    ARFRP1Q137953, ENSP000003268844I2D: score=3 STRING: ENSP00000326884
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    ARF1P840773, ENSP000002721024I2D: score=1 STRING: ENSP00000272102
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IDA12606567
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0043087regulation of GTPase activity TAS9050849
    GO:0090162establishment of epithelial cell polarity IEA--

    Find genes that share ontologies with CYTH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYTH1 (CYH1)

    1 HMDB Compound for CYTH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for CYTH1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 92.3 13 10913124 (3), 10480924 (2), 18042453 (2), 17398095 (1) (see all 5)
    gdp 79 11 10608818 (3), 9050849 (2), 14690595 (2), 12571360 (1) (see all 5)
    phosphatidylinositol-3,4,5-trisphosphate 74.2 1 10341214 (1)
    gtp 71.6 13 10608818 (3), 10480924 (1), 12571360 (1), 15671486 (1) (see all 7)
    nitrilotriacetic acid 67.3 2 11927660 (1), 10913124 (1)
    guanosine 5'-o-(3-thiotriphosphate) 62 5 10393931 (1), 9050849 (1), 10212218 (1)
    adp 58.4 14 9539714 (2), 10608818 (2), 9653114 (2), 11747824 (1) (see all 9)
    hampshire 54.8 2 11927660 (1), 10913124 (1)
    phosphatidylinositol 29.7 5 11927660 (2), 11438522 (1), 15778383 (1)
    magnesium 7.92 2 11927660 (1)



    Find genes that share compounds with CYTH1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYTH1 gene (2 alternative transcripts): 
    NM_004762.2  NM_017456.2  

    Unigene Cluster for CYTH1:

    Cytohesin 1
    Hs.191215  [show with all ESTs]
    Unigene Representative Sequence: AK123894
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585509 ENST00000589297 ENST00000591455 ENST00000446868(uc010wtv.2 uc002jvw.3 uc010wtw.1 uc010wtx.1)
    ENST00000589296 ENST00000586299 ENST00000586175 ENST00000591574 ENST00000586430
    ENST00000590775 ENST00000589768 ENST00000586043 ENST00000587308 ENST00000590300
    ENST00000591095 ENST00000592497 ENST00000361101(uc021ueg.1)
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    hsa-miR-429 hsa-miR-4328 hsa-miR-624 hsa-miR-138-2* hsa-miR-764 hsa-miR-1304 hsa-miR-629* hsa-miR-3116
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    Additional mRNA sequence: 

    AF054997.1 AK091369.1 AK123894.1 AK293894.1 AK296914.1 AK307917.1 AK311535.1 AK316075.1 
    AK316277.1 AL832791.1 BC038385.1 BC050452.1 M85169.1 

    18 DOTS entries:

    DT.100787619  DT.415947  DT.97844908  DT.91989178  DT.120932252  DT.120932299  DT.120932269  DT.100787617 
    DT.100771105  DT.100787613  DT.95105404  DT.97844909  DT.120932265  DT.120932304  DT.120932349  DT.92021422 
    DT.92434453  DT.95153369 

    Selected AceView cDNA sequences (see all 242):

    BM724114 BQ229465 BM970974 BE503829 AF054997 BX956093 AA732474 CA434673 
    AK123894 BQ055412 BQ943724 BU857181 BF990268 BG001961 BM472168 AA480859 
    BQ639445 CB215130 BC038385 AI986453 BQ229471 BC050452 BF995338 AI061316 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYTH1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:              -     -     -     -                                                                             -                     
    SP2:                                                                                                                                    
    SP3:              -     -     -     -     -           -                       -     -     -     -                 -                     
    SP4:                    -     -     -                                                                                                   
    SP5:                          -     -                                                                                                   


    ECgene alternative splicing isoforms for CYTH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYTH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTCCAGG
    CYTH1 Expression
    About this image


    CYTH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Stomach (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    CYTH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYTH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191215

    UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth11 , 5 cytohesin 11, 5 88.19(n)1
    96.98(a)1
      11 (82.96 cM)5
    191571  NM_001112700.11  NP_001106170.11 
     1181320195 
    chicken
    (Gallus gallus)
    Aves CYTH11 cytohesin 1 84.17(n)
    97.74(a)
      422085  NM_001031105.2  NP_001026276.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYTH16
    cytohesin 1
    91(a)
    1 ↔ 1
    2(101824978-101869481)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cyth21 cytohesin 2 78.12(n)
    91.79(a)
      448569  NM_001005039.1  NP_001005039.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc89h042 wufc89h04 79.88(n)   325586  BC059497.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta step1 steppke 63.96(n)
    69.11(a)
      35425  NM_136276.4  NP_610120.1 
    worm
    (Caenorhabditis elegans)
    Secernentea grp-16
    Protein GRP-1 (grp-1) mRNA, complete cds
    39(a)
    1 → many
    III(8085705-8088448) WBGene00001743
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    7(a)
    1 → many
    IV(796193-802222) YDR170C


    ENSEMBL Gene Tree for CYTH1 (if available)
    TreeFam Gene Tree for CYTH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYTH1 gene
    CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  IQSEC22  
    CYTH42  FBXO82  
    13 SIMAP similar genes for CYTH1 using alignment to 8 protein entries:     CYH1_HUMAN (see all proteins):
    PSCD2L    CYTH3    CYTH2    FLJ00017    CYTH4    ARFGEF2
    ARFGEF1    IQSEC2    IQSEC1    IQSEC3    FAM109A    GBF1
    PSD3

    Find genes that share paralogs with CYTH1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CYTH1
    PGOHUM00000238802 PGOHUM00000241660


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYTH1 (see all 2328)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911651261,2
    --72202966(+) AGATTA/TGCAGA 2 -- us2k10--------
    rs1896197591,2
    --76669635(+) AGGAAA/GCATCA 2 -- ds50010--------
    rs1428221951,2
    --76669667(+) AAGAAC/TGCGGA 2 -- ds50010--------
    rs1474101361,2
    --76669668(+) AGAACA/GCGGAC 2 -- ds50010--------
    rs65012381,2
    C,F,A,H--76669739(+) GGTGCC/TGGTTC 2 -- ds500126Minor allele frequency- T:0.45NA NS EA WA CSA 2294
    rs47968321,2
    C,F,H--76669881(+) TTCTTG/CATCTT 2 -- ds500110Minor allele frequency- C:0.14NS EA NA WA 996
    rs776877461,2
    F--76669931(+) GGGGCG/AGTGCA 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1819165681,2
    --76669945(+) ACTAAA/GTTACT 2 -- ds50010--------
    rs353305111,2
    C,F,H--76670088(+) ACCTCG/AAGGGC 2 -- ds500116Minor allele frequency- A:0.06NS EA NA 1998
    rs1865320401,2
    --76670172(+) CTTGGC/TGCTAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CYTH1 (76670130 - 76778379 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CYTH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716320CNV Deletion23290073
    esv2716321CNV Deletion23290073
    nsv908893CNV Loss21882294
    nsv819517CNV Loss19587683
    nsv482920CNV Loss15286789
    nsv522366CNV Gain19592680
    nsv519983CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYTH1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYTH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182115    OMIM disorders: --


    Find genes that share disorders with CYTH1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CYTH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 21.8 1 9756891 (1)


    Export disorders for CYTH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYTH1 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with CYTH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7. (PubMed id 1511013)1, 2, 3 Liu L. and Pohajdak B. (Biochim. Biophys. Acta 1992)
    2. Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PubMed id 10748148)1, 2, 9 Vitale N.... Vaughan M. (J. Biol. Chem. 2000)
    3. Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. (PubMed id 9653114)1, 2, 9 Betz S.F.... Fesik S.W. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion. (PubMed id 20018626)1, 3, 9 El Azreq M.A....Bourgoin S.G. (J. Immunol. 2010)
    5. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2, 9 Ogasawara M.... Vaughan M. (J. Biol. Chem. 2000)
    6. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PubMed id 11867758)1, 2, 9 Tang P.... Gadina M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. (PubMed id 8449036)1, 3, 9 Dixon B....Pohajdak B. (Cytogenet. Cell Genet. 1993)
    8. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I.... Munro S. (Curr. Biol. 2007)
    9. Editorial: Cytohesin-1, on the tail of two integrins. (PubMed id 21628335)1, 3 Hyduk S.J. and Cybulsky M.I. (J. Leukoc. Biol. 2011)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9267 HGNC: 9501 AceView: PSCD1 Ensembl:ENSG00000108669 euGenes: HUgn9267
    ECgene: CYTH1 H-InvDB: CYTH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYTH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYTH1 gene:
    Search GeneIP for patents involving CYTH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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