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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYTH1 Gene

protein-coding GIFtS: 59
GCID: GC17M076670

cytohesin 1

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains 1 )
(Previous symbol: PSCD1)

Explore 10 diseases affiliated with
CYTH1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytohesin 1¹ ²		SEC7 Homolog B2-1² ³
D17S811E¹ ² ³ ⁵		SEC7² ⁵
PSCD1¹ ² ³		CYTOHESIN-1²
B2-1¹ ²		Cytoadhesin 1²
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 1¹ ²		Cytohesin-1¹
PH, SEC7 And Coiled-Coil Domain-Containing Protein 1² ³		Homolog Of Secretory Protein SEC7²

External Ids:	HGNC: 9501¹	Entrez Gene: 9267²	Ensembl: ENSG00000108669⁷	OMIM: 182115⁵	UniProtKB: Q15438³

Export aliases for CYTH1 gene to outside databases

Previous GC identifers: GC17M074182 GC17M072092

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYTH1:

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural

organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin

homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains

guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible

for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting

and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the

adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of

CYTH2. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438

Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of

GDP with GTP

Gene Wiki entry for CYTH1 (PSCD1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYTH1 gene promoter:
AML1a AP-1 ATF-2 MyoD AP-4 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYTH1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYTH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25

CYTH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M076670: view genomic region (about GC identifiers)

Start:	76,670,130 bp from pter	End:	76,778,379 bp from pter
Size:	108,250 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438 (See protein sequence)

Recommended Name: Cytohesin-1

Size: 398 amino acids; 46413 Da

Subunit: Interacts with TRIM23 and CYTIP

Subcellular location: Cell membrane

2 PDB 3D structures from and Proteopedia for CYTH1:

1BC9 (3D)

4A4P (3D)

Secondary accessions: A6NFW7 Q9P123 Q9P124

Alternative splicing: 2 isoforms: Q15438-1 Q15438-2

Explore the universe of human proteins at neXtProt for CYTH1: NX_Q15438

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15438

CYTH1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004753.1 NP_059430.2

ENSEMBL proteins:

ENSP00000465940 ENSP00000466512 ENSP00000465665 ENSP00000389095 ENSP00000465252

ENSP00000465945 ENSP00000467052 ENSP00000468433 ENSP00000465530 ENSP00000466949

ENSP00000354398

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CYTH1 OriGene Protein Over-expression Lysate (see all 3): CYTH1 OriGene Custom Protein Services for CYTH1
	GenScript Custom Purified and Recombinant Proteins Services for CYTH1
	Novus Biologicals CYTH1 Protein Novus Biologicals CYTH1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYTH1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IDA	12606567
GO:0005802	NOT trans-Golgi network	IBA	--
GO:0005886	plasma membrane	IDA	12606567
GO:0005923	tight junction	IEA	--

CYTH1 for ontologies About GeneDecksing

CYTH1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CYTH1
	R&D Systems Antibodies for CYTH1 (Cytohesin-1)
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	Novus Biologicals CYTH1 Antibodies
	Abcam antibodies for CYTH1
	Uscn Antibodies for CYTH1
	ThermoFisher Antibody for CYTH1

Assay Products for CYTH1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CYTH1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYTH1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYTH1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR023394 SEC7_alpha_orthog

IPR011993 PH_like_dom

IPR000904 Sec7

Graphical View of Domain Structure for InterPro Entry Q15438

ProtoNet protein and cluster: Q15438

2 Blocks protein families:

IPB000904 SEC7-like domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438

Similarity: Contains 1 PH domain

Similarity: Contains 1 SEC7 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438

Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of

GDP with GTP

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CYTH1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH1
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH1 (see all 58):
		hsa-miR-429 hsa-miR-4328 hsa-miR-624 hsa-miR-138-2* hsa-miR-764 hsa-miR-1304 hsa-miR-629* hsa-miR-3116

		SwitchGear 3'UTR luciferase reporter plasmid: CYTH1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYTH1 (see all 4) OriGene shRNA RFP: CYTH1 OriGene siRNA: CYTH1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CYTH1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYTH1
		Search LifeMap BioReagents cell lines for CYTH1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005086	ARF guanyl-nucleotide exchange factor activity	IBA	--
GO:0005515	protein binding	IPI	11867758
GO:0005543	phospholipid binding	IEA	--

CYTH1 for ontologies About GeneDecksing

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cyth1):

nervous system

CYTH1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

Cell adhesion_Integrin inside-out signaling

Cell adhesion_Integrin inside-out signaling

1.00

Cell adhesion Integrin inside-out signaling

0.99

Class I PI3K signaling events

Class I PI3K signaling events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CYTH1

	Immune response CD16 signaling in NK cells
	Cell adhesion Integrin inside-out signaling

2 GeneGo (Thomson Reuters) Pathways for CYTH1

	Cell adhesion Integrin inside-out signaling
	Immune response CD16 signaling in NK cells

1 BioSystems Pathway for CYTH1

Class I PI3K signaling events

CYTH1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYTH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/17 Interacting proteins for CYTH1 (Q15438^{1, 2, 3} ENSP00000354398⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB2	P05107²^,³, ENSP00000303242⁴	MINT-4652150 I2D: score=5 STRING: ENSP00000303242
CYTIP	O60759¹^,³, ENSP00000264192⁴	EBI-997830,EBI-2803304 I2D: score=4 STRING: ENSP00000264192
ARFRP1	Q13795³, ENSP00000326884⁴	I2D: score=3 STRING: ENSP00000326884
PRKCD	Q05655³, ENSP00000331602⁴	I2D: score=2 STRING: ENSP00000331602
ARF1	P84077³, ENSP00000272102⁴	I2D: score=1 STRING: ENSP00000272102

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016192	NOT vesicle-mediated transport	IBA	--
GO:0030155	regulation of cell adhesion	IDA	12606567
GO:0032012	regulation of ARF protein signal transduction	IEA	--
GO:0090162	establishment of epithelial cell polarity	IEA	--

CYTH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYTH1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYTH1

1 HMDB Compound for CYTH1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

10/13 Novoseek chemical compound relationships for CYTH1 gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
grp-1	92.3	13	10913124 (3), 10480924 (2), 18042453 (2), 17398095 (1) (see all 5)
gdp	79	11	10608818 (3), 9050849 (2), 14690595 (2), 12571360 (1) (see all 5)
phosphatidylinositol-3,4,5-trisphosphate	74.2	1	10341214 (1)
gtp	71.6	13	10608818 (3), 10480924 (1), 12571360 (1), 15671486 (1) (see all 7)
nitrilotriacetic acid	67.3	2	11927660 (1), 10913124 (1)
guanosine 5'-o-(3-thiotriphosphate)	62	5	10393931 (1), 9050849 (1), 10212218 (1)
adp	58.4	14	9539714 (2), 10608818 (2), 9653114 (2), 11747824 (1) (see all 9)
hampshire	54.8	2	11927660 (1), 10913124 (1)
phosphatidylinositol	29.7	5	11927660 (2), 11438522 (1), 15778383 (1)
magnesium	7.92	2	11927660 (1)

Search CenterWatch for drugs/clinical trials and news about CYTH1 / CYH1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYTH1 gene (2 alternative transcripts):

NM_004762.2 NM_017456.2

Unigene Cluster for CYTH1:

Cytohesin 1

Hs.191215 [show with all ESTs]

Unigene Representative Sequence: AK123894

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000585509 ENST00000589297 ENST00000591455 ENST00000446868(uc010wtv.2 uc002jvw.3 uc010wtw.1 uc010wtx.1)

ENST00000589296 ENST00000586299 ENST00000586175 ENST00000591574 ENST00000586430

ENST00000590775 ENST00000589768 ENST00000586043 ENST00000587308 ENST00000590300

ENST00000591095 ENST00000592497 ENST00000361101(uc021ueg.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYTH1
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CYTH1 (see all 58):
		hsa-miR-429 hsa-miR-4328 hsa-miR-624 hsa-miR-138-2* hsa-miR-764 hsa-miR-1304 hsa-miR-629* hsa-miR-3116

		SwitchGear 3'UTR luciferase reporter plasmid: CYTH1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYTH1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AF054997.1 AK091369.1 AK123894.1 AK293894.1 AK296914.1 AK307917.1 AK311535.1 AK316075.1

AK316277.1 AL832791.1 BC038385.1 BC050452.1 M85169.1

18 DOTS entries:

DT.100787619 DT.415947 DT.97844908 DT.91989178 DT.120932252 DT.120932299 DT.120932269 DT.100787617

DT.100771105 DT.100787613 DT.95105404 DT.97844909 DT.120932265 DT.120932304 DT.120932349 DT.92021422

DT.92434453 DT.95153369

24/242 AceView cDNA sequences (see all 242):

AK123894 BF990268 BU956644 AI085344 CD674237 BU857181 BM970974 AA732474

CA434673 BQ639445 BM472168 BM724114 BX956093 AA480859 BQ229465 CA309933

AF054997 AI061316 CB215130 BC038385 BQ058923 BC050452 CB048312 BF995338

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH1 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c
SP1:					-		-		-		-																										-
SP2:
SP3:					-		-		-		-		-				-								-		-		-		-						-
SP4:							-		-		-
SP5:									-		-

ECgene alternative splicing isoforms for CYTH1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYTH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGTCCAGG

About this image

CYTH1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYTH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYTH1

SOURCE GeneReport for Unigene cluster: Hs.191215

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for CYTH1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYTH1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CYTH1 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYTH1¹	cytohesin 1	84.17(n) 97.74(a)		422085 NM_001031105.1 NP_001026276.1
lizard (Anolis carolinensis)	Reptilia	CYTH1⁶	--	92(a)	1 ↔ 1	2(101851079-101869481)
zebrafish (Danio rerio)	Actinopterygii	wufc89h04²	wufc89h04	79.88(n)		325586 BC059497.1
fruit fly (Drosophila melanogaster)	Insecta	step¹	steppke	64.34(n) 70.11(a)		35425 NM_001042910.2 NP_001036375.2
worm (Caenorhabditis elegans)	Secernentea	grp-1⁶	GTP exchange factor for ARFs 1	36(a)	1 → many	III(8085638-8088382)

ENSEMBL Gene Tree for CYTH1 (if available)
TreeFam Gene Tree for CYTH1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYTH1 gene

PSD3² GBF1² CYTH3² IQSEC3² CYTH2² ARFGEF2² PSD4² ARFGEF1²

IQSEC1² PSD2² PSD² IQSEC2² CYTH4² FBXO8²

13 SIMAP similar genes for CYTH1 using alignment to 8 protein entries: CYH1_HUMAN (see all proteins):

PSCD2L CYTH3 CYTH2 FLJ00017 CYTH4 ARFGEF2

ARFGEF1 IQSEC2 IQSEC1 IQSEC3 FAM109A GBF1

PSD3

CYTH1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for CYTH1
PGOHUM00000238802 PGOHUM00000241660

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11291374^1,2	C	--	72187819(+)	`GTCTC-/AAAAAA`	1	--	int¹ trp³		2		NA CSA	4
rs189619759^1,2		--	76669635(+)	`AGGAAA/GCATCA`	2	--	ds500¹		0	--	--	--	--
rs142822195^1,2		--	76669667(+)	`AAGAAC/TGCGGA`	2	--	ds500¹		0	--	--	--	--
rs147410136^1,2		--	76669668(+)	`AGAACA/GCGGAC`	2	--	ds500¹		0	--	--	--	--
rs6501238^1,2	C,F,A,H,	--	76669739(+)	`GGTGCC/TGGTTC`	2	--	ds500¹		26		NA NS EA WA CSA	2294
rs4796832^1,2	C,F,H,	--	76669881(+)	`TTCTTG/CATCTT`	2	--	ds500¹		10		NS EA NA WA	996
rs77687746^1,2	F,	--	76669931(+)	`GGGGCG/AGTGCA`	2	--	ds500¹		1		WA	118
rs181916568^1,2		--	76669945(+)	`ACTAAA/GTTACT`	2	--	ds500¹		0	--	--	--	--
rs35330511^1,2	C,F,H,	--	76670088(+)	`ACCTCG/AAGGGC`	2	--	ds500¹		16		NS EA NA	1998
rs186532040^1,2		--	76670172(+)	`CTTGGC/TGCTAG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYTH1 (76670130 - 76778379 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYTH1
2 CNVs: 58818 0212

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYTH1 for disorders           About GeneDecksing

OMIM gene information: 182115    OMIM disorders: --

10 diseases for CYTH1:    About MalaCards

fibrous histiocytoma malignant fibrous histiocytoma anaplastic large cell lymphoma acute disseminated encephalomyelitis

histiocytoma batten disease cholera encephalomyelitis

blindness sarcoma

1 Novoseek disease relationship for CYTH1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholera	21.8	1	9756891 (1)

Export disorders for CYTH1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYTH1 gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with CYTH1)

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Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7. (PubMed id 1511013)^{1, 2, 3} Liu L. and Pohajdak B. (1992)
Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PubMed id 10748148)^{1, 2, 9} Vitale N.... Vaughan M. (2000)
Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. (PubMed id 9653114)^{1, 2, 9} Betz S.F.... Fesik S.W. (1998)
Cytohesin-1 regulates the Arf6-phospholipase D signal ing axis in human neutrophils: impact on superoxide anion production and secret ion. (PubMed id 20018626)^{1, 3, 9} El Azreq M.A....Bourgoin S.G. (2010)
Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)^{1, 2, 9} Ogasawara M.... Vaughan M. (2000)
Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PubMed id 11867758)^{1, 2, 9} Tang P.... Gadina M. (2002)
Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. (PubMed id 8449036)^{1, 3, 9} Dixon B....Pohajdak B. (1993)
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)^{1, 2, 9} Hofmann I....Munro S. (2007)
Editorial: Cytohesin-1, on the tail of two integrins. (PubMed id 21628335)^{1, 3} Hyduk S.J. and Cybulsky M.I. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9267	HGNC: 9501	AceView: PSCD1	Ensembl:ENSG00000108669	euGenes: HUgn9267
ECgene: CYTH1	H-InvDB: CYTH1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYTH1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYTH1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYTH1 gene:
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GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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