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Aliases for CYTH1 Gene

Aliases for CYTH1 Gene

  • Cytohesin 1 2 3
  • D17S811E 3 4 6
  • PH, SEC7 And Coiled-Coil Domain-Containing Protein 1 3 4
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains 1 2 3
  • SEC7 Homolog B2-1 3 4
  • PSCD1 3 4
  • SEC7 3 6
  • Homolog Of Secretory Protein SEC7 3
  • Cytoadhesin 1 3
  • CYTOHESIN-1 3
  • B2-1 3

External Ids for CYTH1 Gene

Previous Symbols for CYTH1 Gene

  • PSCD1

Summaries for CYTH1 Gene

Entrez Gene Summary for CYTH1 Gene

  • The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for CYTH1 Gene

CYTH1 (Cytohesin 1) is a Protein Coding gene. Among its related pathways are Class I PI3K signaling events and Development Angiotensin activation of ERK. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

UniProtKB/Swiss-Prot for CYTH1 Gene

  • Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Wiki entry for CYTH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTH1 Gene

Genomics for CYTH1 Gene

Genomic Location for CYTH1 Gene

Start:
78,674,048 bp from pter
End:
78,782,297 bp from pter
Size:
108,250 bases
Orientation:
Minus strand

Genomic View for CYTH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYTH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTH1 Gene

Regulatory Elements for CYTH1 Gene

Proteins for CYTH1 Gene

  • Protein details for CYTH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15438-CYH1_HUMAN
    Recommended name:
    Cytohesin-1
    Protein Accession:
    Q15438
    Secondary Accessions:
    • A6NFW7
    • B7Z1T4
    • Q9P123
    • Q9P124

    Protein attributes for CYTH1 Gene

    Size:
    398 amino acids
    Molecular mass:
    46413 Da
    Quaternary structure:
    • Interacts with TRIM23 and CYTIP.

    Three dimensional structures from OCA and Proteopedia for CYTH1 Gene

    Alternative splice isoforms for CYTH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYTH1 Gene

Proteomics data for CYTH1 Gene at MOPED

Post-translational modifications for CYTH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYTH1 Gene

Domains for CYTH1 Gene

Gene Families for CYTH1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for CYTH1 Gene

Suggested Antigen Peptide Sequences for CYTH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15438

UniProtKB/Swiss-Prot:

CYH1_HUMAN
Domain:
  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.:
    • Q15438
  • Autoinhibited by its C-terminal basic region.:
    • Q15438
  • Contains 1 PH domain.:
    • Q15438
  • Contains 1 SEC7 domain.:
    • Q15438
genes like me logo Genes that share domains with CYTH1: view

Function for CYTH1 Gene

Molecular function for CYTH1 Gene

UniProtKB/Swiss-Prot Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Ontology (GO) - Molecular Function for CYTH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IDA 10652308
GO:0005515 protein binding IPI 11867758
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with CYTH1: view

Phenotypes for CYTH1 Gene

MGI mutant phenotypes for CYTH1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CYTH1: view

miRNA for CYTH1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYTH1 Gene

Localization for CYTH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTH1 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYTH1 Gene COMPARTMENTS Subcellular localization image for CYTH1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
golgi apparatus 3
endoplasmic reticulum 2
endosome 2
nucleus 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CYTH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12606567
GO:0005802 NOT trans-Golgi network IBA --
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane IDA 12606567
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with CYTH1: view

Pathways for CYTH1 Gene

genes like me logo Genes that share pathways with CYTH1: view

Pathways by source for CYTH1 Gene

1 BioSystems pathway for CYTH1 Gene

Gene Ontology (GO) - Biological Process for CYTH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 NOT vesicle-mediated transport IBA --
GO:0030155 regulation of cell adhesion IDA 12606567
GO:0032012 regulation of ARF protein signal transduction --
GO:0043547 positive regulation of GTPase activity TAS 9050849
GO:0090162 establishment of epithelial cell polarity IEA --
genes like me logo Genes that share ontologies with CYTH1: view

Compounds for CYTH1 Gene

(1) HMDB Compounds for CYTH1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(13) Novoseek inferred chemical compound relationships for CYTH1 Gene

Compound -log(P) Hits PubMed IDs
grp-1 92.3 9
gdp 79 9
phosphatidylinositol-3,4,5-trisphosphate 74.2 1
gtp 71.6 9
nitrilotriacetic acid 67.3 2
genes like me logo Genes that share compounds with CYTH1: view

Transcripts for CYTH1 Gene

Unigene Clusters for CYTH1 Gene

Cytohesin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYTH1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP2:
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for CYTH1 Gene

GeneLoc Exon Structure for
CYTH1
ECgene alternative splicing isoforms for
CYTH1

Expression for CYTH1 Gene

mRNA expression in normal human tissues for CYTH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTH1 Gene

This gene is overexpressed in Whole Blood (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYTH1 Gene

SOURCE GeneReport for Unigene cluster for CYTH1 Gene Hs.191215

mRNA Expression by UniProt/SwissProt for CYTH1 Gene

Q15438-CYH1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CYTH1: view

Orthologs for CYTH1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYTH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTH1 35
  • 99.32 (n)
  • 99.75 (a)
CYTH1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYTH1 35
  • 90.19 (n)
  • 98.73 (a)
CYTH1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYTH1 35
  • 92.5 (n)
  • 100 (a)
CYTH1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyth1 35
  • 88.19 (n)
  • 96.98 (a)
Cyth1 16
Cyth1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYTH1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYTH1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyth1 35
  • 89.28 (n)
  • 98.24 (a)
chicken
(Gallus gallus)
Aves CYTH1 35
  • 84.17 (n)
  • 97.74 (a)
CYTH1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYTH1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyth2 35
  • 78.12 (n)
  • 91.79 (a)
zebrafish
(Danio rerio)
Actinopterygii cyth1a 35
  • 80.13 (n)
  • 93.18 (a)
cyth1a 36
  • 92 (a)
OneToMany
cyth1b 36
  • 91 (a)
OneToMany
wufc89h04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008737 35
  • 66.2 (n)
  • 71.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta step 35
  • 63.96 (n)
  • 69.11 (a)
step 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grp-1 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC7 36
  • 7 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.707 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
ManyToMany
CSA.8851 36
  • 65 (a)
ManyToMany
Species with no ortholog for CYTH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYTH1 Gene

ENSEMBL:
Gene Tree for CYTH1 (if available)
TreeFam:
Gene Tree for CYTH1 (if available)

Paralogs for CYTH1 Gene

Pseudogenes.org Pseudogenes for CYTH1 Gene

genes like me logo Genes that share paralogs with CYTH1: view

Variants for CYTH1 Gene

Sequence variations from dbSNP and Humsavar for CYTH1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6728 -- 78,674,151(-) ACAGG(C/G)TTTTT utr-variant-3-prime
rs900354 -- 78,716,831(-) TCACA(A/C)CTCAG intron-variant
rs922838 -- 78,696,216(+) AACGA(C/G/T)GGGCT intron-variant
rs1042289 -- 78,701,715(-) TTTGT(G/T)GAGCT reference, synonymous-codon
rs1126607 -- 78,675,920(-) TGGGC(A/G)GTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYTH1 Gene

Variant ID Type Subtype PubMed ID
nsv482920 CNV Loss 15286789
esv2716320 CNV Deletion 23290073
nsv819517 CNV Loss 19587683
nsv519983 CNV Gain 19592680
nsv522366 CNV Gain 19592680
esv2716321 CNV Deletion 23290073
nsv908893 CNV Loss 21882294

Relevant External Links for CYTH1 Gene

HapMap Linkage Disequilibrium report
CYTH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTH1 Gene

Disorders for CYTH1 Gene

(1) Novoseek inferred disease relationships for CYTH1 Gene

Disease -log(P) Hits PubMed IDs
cholera 21.8 1
genes like me logo Genes that share disorders with CYTH1: view

No data available for UniProtKB/Swiss-Prot for CYTH1 Gene

Publications for CYTH1 Gene

  1. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. (PMID: 8449036) Dixon B. … Pohajdak B. (Cytogenet. Cell Genet. 1993) 2 3 23
  2. Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. (PMID: 9653114) Betz S.F. … Fesik S.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PMID: 10652308) Ogasawara M. … Vaughan M. (J. Biol. Chem. 2000) 3 4 23
  4. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PMID: 11867758) Tang P. … Gadina M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  5. Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion. (PMID: 20018626) El Azreq M.A. … Bourgoin S.G. (J. Immunol. 2010) 2 3 23

Products for CYTH1 Gene

Sources for CYTH1 Gene

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