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Aliases for CYTH1 Gene

Aliases for CYTH1 Gene

  • Cytohesin 1 2 3 5
  • PH, SEC7 And Coiled-Coil Domain-Containing Protein 1 3 4
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains 1 2 3
  • SEC7 Homolog B2-1 3 4
  • D17S811E 3 4
  • PSCD1 3 4
  • Homolog Of Secretory Protein SEC7 3
  • Cytoadhesin 1 3
  • B2-1 3
  • SEC7 3

External Ids for CYTH1 Gene

Previous HGNC Symbols for CYTH1 Gene

  • PSCD1

Previous GeneCards Identifiers for CYTH1 Gene

  • GC17M074182
  • GC17M076670
  • GC17M072092

Summaries for CYTH1 Gene

Entrez Gene Summary for CYTH1 Gene

  • The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for CYTH1 Gene

CYTH1 (Cytohesin 1) is a Protein Coding gene. Among its related pathways are Development Angiotensin activation of ERK and Phospholipase D signaling pathway. GO annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

UniProtKB/Swiss-Prot for CYTH1 Gene

  • Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Wiki entry for CYTH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTH1 Gene

Genomics for CYTH1 Gene

Regulatory Elements for CYTH1 Gene

Enhancers for CYTH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYTH1 on UCSC Golden Path with GeneCards custom track

Promoters for CYTH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYTH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYTH1 Gene

78,674,047 bp from pter
78,782,342 bp from pter
108,296 bases
Minus strand

Genomic View for CYTH1 Gene

Genes around CYTH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTH1 Gene

Proteins for CYTH1 Gene

  • Protein details for CYTH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NFW7
    • B7Z1T4
    • Q9P123
    • Q9P124

    Protein attributes for CYTH1 Gene

    398 amino acids
    Molecular mass:
    46413 Da
    Quaternary structure:
    • Interacts with TRIM23 and CYTIP.

    Three dimensional structures from OCA and Proteopedia for CYTH1 Gene

    Alternative splice isoforms for CYTH1 Gene


neXtProt entry for CYTH1 Gene

Proteomics data for CYTH1 Gene at MOPED

Post-translational modifications for CYTH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for CYTH1

No data available for DME Specific Peptides for CYTH1 Gene

Domains & Families for CYTH1 Gene

Gene Families for CYTH1 Gene

Protein Domains for CYTH1 Gene

Suggested Antigen Peptide Sequences for CYTH1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
  • Autoinhibited by its C-terminal basic region.
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
genes like me logo Genes that share domains with CYTH1: view

Function for CYTH1 Gene

Molecular function for CYTH1 Gene

UniProtKB/Swiss-Prot Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Ontology (GO) - Molecular Function for CYTH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IDA 10652308
genes like me logo Genes that share ontologies with CYTH1: view
genes like me logo Genes that share phenotypes with CYTH1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYTH1 Gene

Localization for CYTH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTH1 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for CYTH1 Gene COMPARTMENTS Subcellular localization image for CYTH1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
golgi apparatus 3
nucleus 3
endoplasmic reticulum 2
endosome 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CYTH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IDA 12606567
GO:0005886 plasma membrane IDA 12606567
genes like me logo Genes that share ontologies with CYTH1: view

Pathways & Interactions for CYTH1 Gene

genes like me logo Genes that share pathways with CYTH1: view

Pathways by source for CYTH1 Gene

Gene Ontology (GO) - Biological Process for CYTH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport TAS 1511013
GO:0043547 positive regulation of GTPase activity TAS 9050849
genes like me logo Genes that share ontologies with CYTH1: view

No data available for SIGNOR curated interactions for CYTH1 Gene

Drugs & Compounds for CYTH1 Gene

(4) Drugs for CYTH1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(10) Additional Compounds for CYTH1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYTH1: view

Transcripts for CYTH1 Gene

Unigene Clusters for CYTH1 Gene

Cytohesin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYTH1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - -

Relevant External Links for CYTH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYTH1 Gene

mRNA expression in normal human tissues for CYTH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTH1 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for CYTH1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.3) and Serum (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYTH1 Gene

SOURCE GeneReport for Unigene cluster for CYTH1 Gene Hs.191215

mRNA Expression by UniProt/SwissProt for CYTH1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CYTH1: view

Primer Products

No data available for Protein tissue co-expression partners for CYTH1 Gene

Orthologs for CYTH1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYTH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYTH1 35
  • 90.19 (n)
  • 98.73 (a)
CYTH1 36
  • 96 (a)
(Canis familiaris)
Mammalia CYTH1 35
  • 92.5 (n)
  • 100 (a)
CYTH1 36
  • 98 (a)
(Mus musculus)
Mammalia Cyth1 35
  • 88.19 (n)
  • 96.98 (a)
Cyth1 16
Cyth1 36
  • 97 (a)
(Pan troglodytes)
Mammalia CYTH1 35
  • 99.32 (n)
  • 99.75 (a)
CYTH1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cyth1 35
  • 89.28 (n)
  • 98.24 (a)
(Monodelphis domestica)
Mammalia CYTH1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia CYTH1 36
  • 92 (a)
(Gallus gallus)
Aves CYTH1 35
  • 84.17 (n)
  • 97.74 (a)
CYTH1 36
  • 99 (a)
(Anolis carolinensis)
Reptilia CYTH1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyth2 35
  • 78.12 (n)
  • 91.79 (a)
(Danio rerio)
Actinopterygii cyth1a 35
  • 80.13 (n)
  • 93.18 (a)
wufc89h04 35
cyth1a 36
  • 92 (a)
cyth1b 36
  • 91 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008737 35
  • 66.2 (n)
  • 71.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta step 35
  • 63.96 (n)
  • 69.11 (a)
step 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea grp-1 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC7 36
  • 7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.707 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
CSA.8851 36
  • 65 (a)
Species with no ortholog for CYTH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYTH1 Gene

Gene Tree for CYTH1 (if available)
Gene Tree for CYTH1 (if available)

Paralogs for CYTH1 Gene Pseudogenes for CYTH1 Gene

genes like me logo Genes that share paralogs with CYTH1: view

Variants for CYTH1 Gene

Sequence variations from dbSNP and Humsavar for CYTH1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs922838 -- 78,696,216(+) AACGA(C/G/T)GGGCT intron-variant
rs1042289 -- 78,701,715(-) TTTGT(G/T)GAGCT nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1139101 -- 78,678,991(-) ATCCT(A/C)TCAAA intron-variant
rs2128373 -- 78,697,192(+) ACCAA(A/G)AGAGT intron-variant
rs1871935 -- 78,768,063(-) TGAAA(A/G)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYTH1 Gene

Variant ID Type Subtype PubMed ID
nsv482920 CNV Loss 15286789
esv2716320 CNV Deletion 23290073
nsv819517 CNV Loss 19587683
nsv519983 CNV Gain 19592680
nsv522366 CNV Gain 19592680
esv2716321 CNV Deletion 23290073
nsv908893 CNV Loss 21882294

Variation tolerance for CYTH1 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYTH1 Gene

Disorders for CYTH1 Gene

Relevant External Links for CYTH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYTH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTH1 Gene

Publications for CYTH1 Gene

  1. Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7. (PMID: 1511013) Liu L. … Pohajdak B. (Biochim. Biophys. Acta 1992) 2 3 4 67
  2. Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion. (PMID: 20018626) El Azreq M.A. … Bourgoin S.G. (J. Immunol. 2010) 2 3 23
  3. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. (PMID: 8449036) Dixon B. … Pohajdak B. (Cytogenet. Cell Genet. 1993) 2 3 23
  4. Editorial: Cytohesin-1, on the tail of two integrins. (PMID: 21628335) Hyduk S.J. … Cybulsky M.I. (J. Leukoc. Biol. 2011) 2 3
  5. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I. … Munro S. (Curr. Biol. 2007) 3 23

Products for CYTH1 Gene

Sources for CYTH1 Gene