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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYTH1 Gene

protein-coding   GIFtS: 58
GCID: GC17M076670

Cytohesin 1

(Previous names: pleckstrin homology, Sec7 and coiled-coil domains 1)
(Previous symbol: PSCD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytohesin 11 2     SEC72 5
PSCD11 2 3     B2-12
D17S811E2 3 5     CYTOHESIN-12
Pleckstrin Homology, Sec7 And Coiled-Coil Domains 11 2     Cytoadhesin 12
PH, SEC7 And Coiled-Coil Domain-Containing Protein 12 3     cytohesin-12
SEC7 Homolog B2-12 3     Homolog Of Secretory Protein SEC72

External Ids:    HGNC: 95011   Entrez Gene: 92672   Ensembl: ENSG000001086697   OMIM: 1821155   UniProtKB: Q154383   

Export aliases for CYTH1 gene to outside databases

Previous GC identifers: GC17M074182 GC17M072092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYTH1 Gene:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin
homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains
guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of
protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells,
and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83%
homologous to that of CYTH2. (provided by RefSeq, Aug 2008)

GeneCards Summary for CYTH1 Gene: 
CYTH1 (cytohesin 1) is a protein-coding gene. Diseases associated with CYTH1 include acute disseminated encephalomyelitis, and alk-positive anaplastic large cell lymphoma, and among its related super-pathways are Development Angiotensin activation of ERK and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through
replacement of GDP with GTP

Gene Wiki entry for CYTH1 (PSCD1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYTH1 gene promoter:
         AML1a   AP-1   ATF-2   MyoD   AP-4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYTH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYTH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYTH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

CYTH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYTH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076670:  view genomic region     (about GC identifiers)

Start:
76,670,130 bp from pter      End:
76,778,379 bp from pter
Size:
108,250 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438 (See protein sequence)
Recommended Name: Cytohesin-1  
Size: 398 amino acids; 46413 Da
Subunit: Interacts with TRIM23 and CYTIP
Subcellular location: Cell membrane
2 PDB 3D structures from and Proteopedia for CYTH1:
1BC9 (3D)        4A4P (3D)    
Secondary accessions: A6NFW7 Q9P123 Q9P124
Alternative splicing: 2 isoforms:  Q15438-1   Q15438-2   

Explore the universe of human proteins at neXtProt for CYTH1: NX_Q15438

Explore proteomics data for CYTH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15438

  • CYTH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYTH1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004753.1  NP_059430.2  

    ENSEMBL proteins: 
     ENSP00000465940   ENSP00000466512   ENSP00000465665   ENSP00000389095   ENSP00000465252  
     ENSP00000465945   ENSP00000467052   ENSP00000468433   ENSP00000465530   ENSP00000466949  
     ENSP00000354398  

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    Novus Biologicals CYTH1 Protein
    Novus Biologicals CYTH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYTH1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12606567
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IDA12606567
    GO:0005923tight junction IEA--

    CYTH1 for ontologies           About GeneDecksing



    CYTH1 Antibody Products: 
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    R&D Systems Antibodies for CYTH1 (Cytohesin-1)
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    Abcam antibodies for CYTH1
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    ThermoFisher Antibody for CYTH1
    LSBio Antibodies in human, mouse, rat for CYTH1 

    Assay Products for CYTH1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYTH1 
    Cloud-Clone Corp. CLIAs for CYTH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 SEC7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7

    Graphical View of Domain Structure for InterPro Entry Q15438

    ProtoNet protein and cluster: Q15438

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    CYTH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYH1_HUMAN, Q15438
    Function: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through
    replacement of GDP with GTP

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005515protein binding IPI11867758
    GO:0005543phospholipid binding IEA--
         
    CYTH1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cyth1):
     nervous system 

    CYTH1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYTH1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYTH1 
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    SwitchGear 3'UTR luciferase reporter plasmidCYTH1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYTH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development Angiotensin activation of ERK
    Cell adhesion Integrin inside-out signaling0.44
    2Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells0.32
    3Class I PI3K signaling events
    Class I PI3K signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CYTH1
        Immune response CD16 signaling in NK cells
    Cell adhesion Integrin inside-out signaling


    2 GeneGo (Thomson Reuters) Pathways for CYTH1
        Cell adhesion Integrin inside-out signaling
    Immune response CD16 signaling in NK cells

    1 BioSystems Pathway for CYTH1
        Class I PI3K signaling events



    CYTH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYTH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/17 Interacting proteins for CYTH1 (Q154381, 2, 3 ENSP000003543984) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051072, 3, ENSP000003032424MINT-4652150 I2D: score=5 STRING: ENSP00000303242
    CYTIPO607591, 3, ENSP000002641924EBI-997830,EBI-997814 I2D: score=4 STRING: ENSP00000264192
    ARFRP1Q137953, ENSP000003268844I2D: score=3 STRING: ENSP00000326884
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    ARF1P840773, ENSP000002721024I2D: score=1 STRING: ENSP00000272102
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030155regulation of cell adhesion IDA12606567
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0090162establishment of epithelial cell polarity IEA--

    CYTH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYTH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYTH1 (CYH1)

    1 HMDB Compound for CYTH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    10/13 Novoseek inferred chemical compound relationships for CYTH1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 92.3 13 10913124 (3), 10480924 (2), 18042453 (2), 17398095 (1) (see all 5)
    gdp 79 11 10608818 (3), 9050849 (2), 14690595 (2), 12571360 (1) (see all 5)
    phosphatidylinositol-3,4,5-trisphosphate 74.2 1 10341214 (1)
    gtp 71.6 13 10608818 (3), 10480924 (1), 12571360 (1), 15671486 (1) (see all 7)
    nitrilotriacetic acid 67.3 2 11927660 (1), 10913124 (1)
    guanosine 5'-o-(3-thiotriphosphate) 62 5 10393931 (1), 9050849 (1), 10212218 (1)
    adp 58.4 14 9539714 (2), 10608818 (2), 9653114 (2), 11747824 (1) (see all 9)
    hampshire 54.8 2 11927660 (1), 10913124 (1)
    phosphatidylinositol 29.7 5 11927660 (2), 11438522 (1), 15778383 (1)
    magnesium 7.92 2 11927660 (1)

    Search CenterWatch for drugs/clinical trials and news about CYTH1 / CYH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYTH1 gene (2 alternative transcripts): 
    NM_004762.2  NM_017456.2  

    Unigene Cluster for CYTH1:

    Cytohesin 1
    Hs.191215  [show with all ESTs]
    Unigene Representative Sequence: AK123894
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585509 ENST00000589297 ENST00000591455 ENST00000446868(uc010wtv.2 uc002jvw.3 uc010wtw.1 uc010wtx.1)
    ENST00000589296 ENST00000586299 ENST00000586175 ENST00000591574 ENST00000586430
    ENST00000590775 ENST00000589768 ENST00000586043 ENST00000587308 ENST00000590300
    ENST00000591095 ENST00000592497 ENST00000361101(uc021ueg.1)
    miRNA
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    hsa-miR-429 hsa-miR-4328 hsa-miR-624 hsa-miR-138-2* hsa-miR-764 hsa-miR-1304 hsa-miR-629* hsa-miR-3116
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF054997.1 AK091369.1 AK123894.1 AK293894.1 AK296914.1 AK307917.1 AK311535.1 AK316075.1 
    AK316277.1 AL832791.1 BC038385.1 BC050452.1 M85169.1 

    18 DOTS entries:

    DT.100787619  DT.415947  DT.97844908  DT.91989178  DT.120932252  DT.120932299  DT.120932269  DT.100787617 
    DT.100771105  DT.100787613  DT.95105404  DT.97844909  DT.120932265  DT.120932304  DT.120932349  DT.92021422 
    DT.92434453  DT.95153369 

    24/242 AceView cDNA sequences (see all 242):

    BF990268 BE503829 CB215130 BM472168 BM724114 AI986453 BQ943724 BQ229471 
    CA309933 AA732474 AK123894 BQ229465 AF054997 BC050452 AA480859 BC038385 
    BF995338 BU626567 BQ639445 CA434673 BU857181 BQ694608 BM970974 BU956644 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CYTH1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:              -     -     -     -                                                                             -                     
    SP2:                                                                                                                                    
    SP3:              -     -     -     -     -           -                       -     -     -     -                 -                     
    SP4:                    -     -     -                                                                                                   
    SP5:                          -     -                                                                                                   


    ECgene alternative splicing isoforms for CYTH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYTH1 expression in normal human tissues (normalized intensities)      CYTH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTCCAGG
    CYTH1 Expression
    About this image


    CYTH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood CD133- Cells   
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood CD133- Cells   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-139
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem ES-209, Meso-prx/latp Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem ES-209, Meso-prx/latp Progenitor

    See CYTH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYTH1

    SOURCE GeneReport for Unigene cluster: Hs.191215

    UniProtKB/Swiss-Prot: CYH1_HUMAN, Q15438
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYTH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYTH1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyth11 , 5 cytohesin 11, 5 88.19(n)1
    96.98(a)1
      11 (82.96 cM)5
    191571  NM_001112700.11  NP_001106170.11 
     1181320195 
    chicken
    (Gallus gallus)
    Aves CYTH11 cytohesin 1 84.17(n)
    97.74(a)
      422085  NM_001031105.1  NP_001026276.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYTH16
    cytohesin 1
    91(a)
    1 ↔ 1
    2(101824978-101869481)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc89h042 wufc89h04 79.88(n)   325586  BC059497.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta step1 steppke 64.34(n)
    70.11(a)
      35425  NM_001042910.2  NP_001036375.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC76
    Guanine nucleotide exchange factor (GEF) for ADP r...
    6(a)
    1 → many
    IV(796193-802222)


    ENSEMBL Gene Tree for CYTH1 (if available)
    TreeFam Gene Tree for CYTH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYTH1 gene
    CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  IQSEC22  
    CYTH42  FBXO82  
    13 SIMAP similar genes for CYTH1 using alignment to 8 protein entries:     CYH1_HUMAN (see all proteins):
    PSCD2L    CYTH3    CYTH2    FLJ00017    CYTH4    ARFGEF2
    ARFGEF1    IQSEC2    IQSEC1    IQSEC3    FAM109A    GBF1
    PSD3

    CYTH1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CYTH1
    PGOHUM00000238802 PGOHUM00000241660


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2328 SNPs in CYTH1 are shown (see all 2328)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911651261,2
    --72202966(+) AGATTA/TGCAGA 2 -- us2k10--------
    rs1896197591,2
    --76669635(+) AGGAAA/GCATCA 2 -- ds50010--------
    rs1428221951,2
    --76669667(+) AAGAAC/TGCGGA 2 -- ds50010--------
    rs1474101361,2
    --76669668(+) AGAACA/GCGGAC 2 -- ds50010--------
    rs65012381,2
    C,F,A,H--76669739(+) GGTGCC/TGGTTC 2 -- ds500126Minor allele frequency- T:0.45NA NS EA WA CSA 2294
    rs47968321,2
    C,F,H--76669881(+) TTCTTG/CATCTT 2 -- ds500110Minor allele frequency- C:0.14NS EA NA WA 996
    rs776877461,2
    F--76669931(+) GGGGCG/AGTGCA 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1819165681,2
    --76669945(+) ACTAAA/GTTACT 2 -- ds50010--------
    rs353305111,2
    C,F,H--76670088(+) ACCTCG/AAGGGC 2 -- ds500116Minor allele frequency- A:0.06NS EA NA 1998
    rs1865320401,2
    --76670172(+) CTTGGC/TGCTAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CYTH1 (76670130 - 76778379 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CYTH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716320CNV Deletion23290073
    esv2716321CNV Deletion23290073
    nsv908893CNV Loss21882294
    nsv819517CNV Loss19587683
    nsv482920CNV Loss15286789
    nsv522366CNV Gain19592680
    nsv519983CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182115    OMIM disorders: --

    12 diseases for CYTH1:    About MalaCards
    acute disseminated encephalomyelitis    alk-positive anaplastic large cell lymphoma    batten disease    cholera
    histiocytoma    fibrous histiocytoma    anaplastic large cell lymphoma    encephalomyelitis
    blindness    sarcoma    lung cancer    endotheliitis


    CYTH1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYTH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 21.8 1 9756891 (1)


    Export disorders for CYTH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYTH1 gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with CYTH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7. (PubMed id 1511013)1, 2, 3 Liu L. and Pohajdak B. (1992)
    2. Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PubMed id 10748148)1, 2, 9 Vitale N.... Vaughan M. (2000)
    3. Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. (PubMed id 9653114)1, 2, 9 Betz S.F.... Fesik S.W. (1998)
    4. Cytohesin-1 regulates the Arf6-phospholipase D signal ing axis in human neutrophils: impact on superoxide anion production and secret ion. (PubMed id 20018626)1, 3, 9 El Azreq M.A....Bourgoin S.G. (2010)
    5. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PubMed id 10652308)1, 2, 9 Ogasawara M.... Vaughan M. (2000)
    6. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PubMed id 11867758)1, 2, 9 Tang P.... Gadina M. (2002)
    7. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. (PubMed id 8449036)1, 3, 9 Dixon B....Pohajdak B. (1993)
    8. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I....Munro S. (2007)
    9. Editorial: Cytohesin-1, on the tail of two integrins. (PubMed id 21628335)1, 3 Hyduk S.J. and Cybulsky M.I. (2011)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9267 HGNC: 9501 AceView: PSCD1 Ensembl:ENSG00000108669 euGenes: HUgn9267
    ECgene: CYTH1 H-InvDB: CYTH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYTH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYTH1 gene:
    Search GeneIP for patents involving CYTH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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