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Aliases for CYSRT1 Gene

Aliases for CYSRT1 Gene

  • Cysteine Rich Tail 1 2 3 5
  • C9orf169 3 4
  • Similar To RIKEN CDNA 2310002J15 Gene 2
  • Chromosome 9 Open Reading Frame 169 2
  • Cysteine-Rich Tail Protein 1 3
  • UPF0574 Protein C9orf169 3

External Ids for CYSRT1 Gene

Previous HGNC Symbols for CYSRT1 Gene

  • C9orf169

Summaries for CYSRT1 Gene

GeneCards Summary for CYSRT1 Gene

CYSRT1 (Cysteine Rich Tail 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSRT1 Gene

Genomics for CYSRT1 Gene

Regulatory Elements for CYSRT1 Gene

Enhancers for CYSRT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G137221 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.1 +2.5 2461 11.2 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B RNF208 CYSRT1 NDOR1 RNF224 SLC34A3 MRPL41 GRIN1 FBXW5 NSMF NPDC1
GH09G137216 1.6 Ensembl ENCODE dbSUPER 6.7 -6.4 -6356 3.7 HDGF PKNOX1 FOXA2 ARNT AGO1 ARID4B SIN3A DMAP1 SLC30A9 FOS NDOR1 RNF208 CYSRT1 NPDC1
GH09G137233 1.8 FANTOM5 ENCODE dbSUPER 5.2 +13.7 13671 9.9 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NDOR1 DPH7 TMEM203 NELFB LCN15 ABCA2 TOR4A UAP1L1 RNF224 CYSRT1
GH09G136323 1.6 FANTOM5 ENCODE dbSUPER 5.4 -896.6 -896613 8.6 PKNOX1 CREB3L1 ZNF133 SIN3A ZNF2 ETS1 GLIS2 FOS ZNF548 ZNF263 SNHG7 ANAPC2 GPSM1 SNAPC4 CYSRT1 LHX3 CAMSAP1 DNLZ
GH09G137204 1.1 ENCODE 6 -18.9 -18923 3.3 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13 CYSRT1 SLC34A3 NDOR1 RNF208
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYSRT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYSRT1 Gene

Chromosome:
9
Start:
137,224,635 bp from pter
End:
137,226,311 bp from pter
Size:
1,677 bases
Orientation:
Plus strand

Genomic View for CYSRT1 Gene

Genes around CYSRT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSRT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSRT1 Gene

Proteins for CYSRT1 Gene

  • Protein details for CYSRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MQ03-CRTP1_HUMAN
    Recommended name:
    Cysteine-rich tail protein 1
    Protein Accession:
    A8MQ03
    Secondary Accessions:
    • Q86UY7

    Protein attributes for CYSRT1 Gene

    Size:
    144 amino acids
    Molecular mass:
    15313 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYSRT1 Gene

Post-translational modifications for CYSRT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYSRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYSRT1 Gene

Domains & Families for CYSRT1 Gene

Protein Domains for CYSRT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYSRT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MQ03

UniProtKB/Swiss-Prot:

CRTP1_HUMAN :
  • Belongs to the CYSRT1 family.
Family:
  • Belongs to the CYSRT1 family.
genes like me logo Genes that share domains with CYSRT1: view

No data available for Gene Families for CYSRT1 Gene

Function for CYSRT1 Gene

genes like me logo Genes that share phenotypes with CYSRT1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYSRT1 Gene

Localization for CYSRT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYSRT1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CYSRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CYSRT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CYSRT1 Gene

Pathways & Interactions for CYSRT1 Gene

SuperPathways for CYSRT1 Gene

No Data Available

Interacting Proteins for CYSRT1 Gene

Selected Interacting proteins: A8MQ03-CRTP1_HUMAN for CYSRT1 Gene via IID

Gene Ontology (GO) - Biological Process for CYSRT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CYSRT1 Gene

Drugs & Compounds for CYSRT1 Gene

No Compound Related Data Available

Transcripts for CYSRT1 Gene

mRNA/cDNA for CYSRT1 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYSRT1 Gene

No ASD Table

Relevant External Links for CYSRT1 Gene

GeneLoc Exon Structure for
CYSRT1
ECgene alternative splicing isoforms for
CYSRT1

Expression for CYSRT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYSRT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CYSRT1 Gene

This gene is overexpressed in Urine (41.1) and Cervix (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYSRT1 Gene



Protein tissue co-expression partners for CYSRT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYSRT1 Gene:

CYSRT1

Evidence on tissue expression from TISSUES for CYSRT1 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with CYSRT1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYSRT1 Gene

Orthologs for CYSRT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYSRT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf169 34
  • 99.09 (n)
C9orf169 35
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf169 34
  • 81.29 (n)
cow
(Bos Taurus)
Mammalia C11H9orf169 34 35
  • 80.27 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560880 34
  • 76.74 (n)
mouse
(Mus musculus)
Mammalia 2310002J15Rik 34 35
  • 76.26 (n)
Cysrt1 16
Species where no ortholog for CYSRT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYSRT1 Gene

ENSEMBL:
Gene Tree for CYSRT1 (if available)
TreeFam:
Gene Tree for CYSRT1 (if available)

Paralogs for CYSRT1 Gene

No data available for Paralogs for CYSRT1 Gene

Variants for CYSRT1 Gene

Sequence variations from dbSNP and Humsavar for CYSRT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000364277 -- 137,224,936(+) CAAGC(A/T)GCAGA utr-variant-5-prime
rs1000707195 -- 137,223,492(+) CAGGC(C/G/T)AGGCC upstream-variant-2KB
rs1000770746 -- 137,223,767(+) ATCGG(A/G)GCCGG upstream-variant-2KB
rs1000987831 -- 137,223,515(+) CCATT(C/G)AGAGC upstream-variant-2KB
rs1001645598 -- 137,226,022(+) CTGCC(A/G)CTGCC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYSRT1 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
dgv13011n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for CYSRT1 Gene

Gene Damage Index Score: 1.29; 25.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYSRT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYSRT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYSRT1 Gene

Disorders for CYSRT1 Gene

Relevant External Links for CYSRT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYSRT1

No disorders were found for CYSRT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYSRT1 Gene

Publications for CYSRT1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  3. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3 64
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3 64

Products for CYSRT1 Gene

Sources for CYSRT1 Gene

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