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CYSLTR2 Gene

protein-coding   GIFtS: 62
GCID: GC13P049280

Cysteinyl Leukotriene Receptor 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteinyl Leukotriene Receptor 21 2     hGPCR212 3
CYSLT22 3 5     HG572
CYSLT2R2 3     KPG_0112
HPN3212 3     Cysteinyl Leukotriene CysLT2 Receptor2
G-Protein Coupled Receptor GPCR212 3     G Protein-Coupled Receptor2
G-Protein Coupled Receptor HG572 3     CysLTR23

External Ids:    HGNC: 182741   Entrez Gene: 571052   Ensembl: ENSG000001522077   OMIM: 6056665   UniProtKB: Q9NS753   

Export aliases for CYSLTR2 gene to outside databases

Previous GC identifers: GC13P047280 GC13P043268 GC13P048217 GC13P047078 GC13P048178 GC13P030074


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYSLTR2 Gene:
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic
studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this
gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems
to play a major role in endocrine and cardiovascular systems. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYSLTR2 Gene:
CYSLTR2 (cysteinyl leukotriene receptor 2) is a protein-coding gene. Diseases associated with CYSLTR2 include fainting, and kaposi's sarcoma. GO annotations related to this gene include cysteinyl leukotriene receptor activity and leukotriene receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75
Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces
specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary
vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4

summary for CYSLTR2 Gene:
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4,
LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase
enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene
receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high
affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are
expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting
that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of
vascular, respiratory and gastrointestinal smooth muscle.

Gene Wiki entry for CYSLTR2 (Cysteinyl leukotriene receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYSLTR2 gene promoter:
         c-Fos   POU2F1   AP-1   POU2F1a   ATF-2   c-Jun   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYSLTR2 promoter sequence
   Search Chromatin IP Primers for CYSLTR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYSLTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.2

CYSLTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYSLTR2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P049280:  view genomic region     (about GC identifiers)

Start:
49,280,951 bp from pter      End:
49,283,498 bp from pter
Size:
2,548 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75 (See protein sequence)
Recommended Name: Cysteinyl leukotriene receptor 2  
Size: 346 amino acids; 39635 Da
Secondary accessions: Q9HCQ2

Explore the universe of human proteins at neXtProt for CYSLTR2: NX_Q9NS75

Explore proteomics data for CYSLTR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn20, Asn26, Asn30, Asn181

  • See CYSLTR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065110.1  
    ENSEMBL proteins: 
     ENSP00000282018  
    Reactome Protein details: Q9NS75

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LTNR: GPCR / Class A : Leukotriene receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CysLT2 receptor
    Leukotriene receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013311 CLT2_recept
     IPR004071 Cyst_leuk_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9NS75

    ProtoNet protein and cluster: Q9NS75

    1 Blocks protein domain: IPB004071 Cysteinyl leukotriene receptor family signature

    UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CYSLTR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLTR2_HUMAN, Q9NS75
    Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a
    phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces
    specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary
    vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001631cysteinyl leukotriene receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004974leukotriene receptor activity NAS10913337
         
    CYSLTR2 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cysltr2):
     cardiovascular system  homeostasis/metabolism  immune system  integument  respiratory system 

    CYSLTR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cysltr2tm1Ykn for CYSLTR2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYSLTR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYSLTR2
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    hsa-miR-1270 hsa-miR-620 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidCYSLTR2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLTR2_HUMAN, Q9NS75: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CYSLTR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYSLTR2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Leukotriene receptors0.00
    5Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYSLTR2
        Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    2 BioSystems Pathways for CYSLTR2
        GPCRs, Class A Rhodopsin-like
    Endothelins

    2 Reactome Pathways for CYSLTR2
        Leukotriene receptors
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for CYSLTR2):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    CYSLTR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYSLTR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYSLTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYSLTR2 (ENSP000002820184) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA1ENSP000002574974STRING: ENSP00000257497
    AVPR1AENSP000002991784STRING: ENSP00000299178
    AVPR1BENSP000003560944STRING: ENSP00000356094
    CCKENSP000003356574STRING: ENSP00000335657
    CIDEBENSP000003377314STRING: ENSP00000337731
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS10913337
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0010942positive regulation of cell death IEA--
    GO:0045766positive regulation of angiogenesis IEA--
    GO:0050909sensory perception of taste ----

    CYSLTR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CYSLTR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-ODYALTB-omega-Hydroxylase inhibitor[34450-18-5]
    MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]
    Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active [128312-51-6]
    LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
    Leukotriene B4BLT1/BLT2 receptor agonist and potent chemotactic factor[71160-24-2]

    1 HMDB Compound for CYSLTR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CYSLTR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nedocromil-- 69049-73-6targetantagonist16164449 17139284 20558817 17016423

    Selected IUPHAR Ligands for CYSLTR2 (CysLT2 receptor) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]LTC4
    AgonistFull agonist6.97 - 10.89547367
    [3H]LTD4
    AgonistFull agonist7.3 - 9.410851239
    BayCysLT2
    AntagonistAntagonist8.321753081
    LTD4
    AgonistFull agonist7.3 - 8.19547367
    N-methyl LTC4
    AgonistFull agonist8.0621078884
    HAMI3379
    AntagonistAntagonist7.4220423349
    LTC4
    AgonistFull agonist7.2421753081
    zafirlukast
    AntagonistAntagonist6.9--
    iralukast
    AntagonistAntagonist6.8--
    BAYu9773
    AntagonistAntagonist6.5 - 6.71331415

    Selected Novoseek inferred chemical compound relationships for CYSLTR2 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltd4 76.5 7 17941281 (2), 9647602 (1), 10913337 (1), 18174606 (1)
    montelukast 72.9 5 17208594 (1), 17460547 (1), 18503712 (1), 19563734 (1)
    leukotriene b4 65.7 11 15544591 (2), 12787679 (1), 15869882 (1), 20097180 (1) (see all 5)
    lte4 64.2 3 9647602 (1), 16304255 (1), 20201353 (1)
    5-oxoete 58.8 1 16159627 (1)
    gdp 43 1 16190775 (1)
    pgd2 42.9 2 17154652 (1)
    aequorin 39.9 1 18566482 (1)
    calcium 34.6 11 12816881 (2), 15643983 (1), 15140381 (1), 16620134 (1) (see all 10)
    gtp 32.8 3 16190775 (1), 10603489 (1), 12719528 (1)



    CYSLTR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYSLTR2 gene: 
    NM_020377.2  

    Unigene Clusters for CYSLTR2:

    Cysteinyl leukotriene receptor 2
    Hs.253706  [show with all ESTs], Hs.614318  [show with all ESTs]
    Unigene Representative Sequences: AB038269, AK291739
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282018(uc001vck.2 uc021rjl.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK291739.1 AY853711.1 BC096832.1 EF141523.1 EF141524.1 EF141525.1 EF141526.1 EF141527.1 
    EF141528.1 EF141529.1 EF141530.1 

    3 DOTS entries:

    DT.75178411  DT.120795348  DT.100670790 

    20 AceView cDNA sequences:

    CD630079 BX280531 CD630084 CD630089 CD630086 NM_020377 CD630072 CD630081 
    CD630087 CD630069 BC069160 AW235714 CD630077 CF147785 CD630075 CD630066 
    CD630067 CD630074 AB038269 BX481095 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYSLTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATTGTAC
    CYSLTR2 Expression
    About this image


    CYSLTR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CYSLTR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYSLTR2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.253706 Hs.614318

    UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75
    Tissue specificity: Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood
    leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle
    cells

        Pathway & Disease-focused RT2 Profiler PCR Array including CYSLTR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYSLTR2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cysltr21 , 5 cysteinyl leukotriene receptor 21, 5 77.27(n)1
    73.05(a)1
      14 (38.54 cM)5
    700861  NM_001162412.11  NP_001155884.11 
     730291285 
    chicken
    (Gallus gallus)
    Aves CYSLTR21 cysteinyl leukotriene receptor 2 62.19(n)
    55.41(a)
      428071  XM_004938708.1  XP_004938765.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    22(a)
    many ↔ many
    GL343558.1(383891-384853)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000027171 cysteinyl leukotriene receptor 1-like 49.88(n)
    43.75(a)
      100002717  XM_001342405.3  XP_001342441.3 


    ENSEMBL Gene Tree for CYSLTR2 (if available)
    TreeFam Gene Tree for CYSLTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYSLTR2 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  
    CYSLTR12  GPR1832  LPAR42  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for CYSLTR2 using alignment to 2 protein entries:     CLTR2_HUMAN (see all proteins) (see all similar genes):
    KPG_011    CYSLTR1    OXGR1    P2RY1    GPR17    F2RL1
    LPAR4    P2RY2    GPR34    GPR30    LPAR6    AGTR2
    GPR183    SSTR4    CCR5    GPR68    CCR1    CCR3

    CYSLTR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYSLTR2 (see all 251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781371371,2
    F--49278977(+) CTATCG/AAGGTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1860937591,2
    --49278997(+) TCCCAA/GGATGT 1 -- us2k10--------
    rs1415818621,2
    C--49279004(+) TGTGG-/TTTTAT 1 -- us2k10--------
    rs745691641,2
    F--49279244(+) TGTTTG/TGCGCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs753455151,2
    C,F--49279246(+) TTTGGC/TGCATA 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs749109731,2
    C--49279307(+) TATAGC/TGTCCC 1 -- us2k10--------
    rs1472420361,2
    --49279471(+) GGTACA/GTAATT 1 -- us2k10--------
    rs1830771191,2
    --49279521(+) ATTGGC/TATATT 1 -- us2k10--------
    rs1864619841,2
    --49279714(+) GTGGAA/CGCTCT 1 -- us2k10--------
    rs1113801051,2
    C--49279734(+) TCTCTA/CTATAT 1 -- us2k12Minor allele frequency- C:0.44CSA WA 119

    HapMap Linkage Disequilibrium report for CYSLTR2 (49280951 - 49283498 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CYSLTR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832604CNV Loss17160897
    nsv832605CNV Gain17160897
    nsv483118CNV Complex15286789

    Human Gene Mutation Database (HGMD): CYSLTR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYSLTR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYSLTR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605666    OMIM disorders: --

    Selected diseases for CYSLTR2 (see all 36):    
    About MalaCards
    fainting    kaposi's sarcoma    leukocyte adhesion deficiency    sleep disorder
    traumatic brain injury    atopy    asthma    brain injury
    rabies    pertussis    rhinitis    leiomyoma
    sinusitis    gingivitis    atopic dermatitis    allergic rhinitis
    atherosclerosis    blindness    ischemia    sarcoma

    2 diseases from the University of Copenhagen DISEASES database for CYSLTR2:
    Asthma     Allergic rhinitis

    CYSLTR2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CYSLTR2 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 50.6 36 16304255 (5), 15475736 (4), 15454733 (3), 15970796 (2) (see all 13)
    asthma allergic 36.2 3 15454733 (1), 17558309 (1)
    inflammation 31.1 11 17693579 (2), 18048362 (1), 18395849 (1), 20064706 (1) (see all 9)
    kaposi sarcoma 30.1 4 10987301 (1), 19258523 (1), 12816350 (1), 15688008 (1)
    atherosclerosis 21.2 2 12193079 (1), 12816350 (1)
    atopy 19.4 1 14515063 (1)
    cardiovascular diseases 13.8 1 10790351 (1)
    nasal polyps 10.7 2 16689996 (1)
    myocardial infarction 0 1 12816881 (1)
    heart diseases 0 2 17557938 (2)

    Genetic Association Database (GAD): CYSLTR2
    Human Genome Epidemiology (HuGE) Navigator: CYSLTR2 (14 documents)

    Export disorders for CYSLTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYSLTR2 gene, integrated from 10 sources (see all 218):
    (articles sorted by number of sources associating them with CYSLTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor. (PubMed id 10913337)1, 2, 3, 9 Takasaki J....Furuichi K. (Biochem. Biophys. Res. Commun. 2000)
    2. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. (PubMed id 15970796)1, 4, 9 Park J.S....Shin H.D. (Pharmacogenet. Genomics 2005)
    3. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. (PubMed id 17460547)1, 4, 9 Klotsman M....Anderson W.H. (Pharmacogenet. Genomics 2007)
    4. Characterization of the human cysteinyl leukotriene 2 receptor. (PubMed id 10851239)1, 2, 9 Heise C.E.... Evans J.F. (J. Biol. Chem. 2000)
    5. Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. (PubMed id 18366797)1, 4, 9 Al-Shemari H....Desrosiers M. (BMC Med. Genet. 2008)
    6. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PubMed id 16771777)1, 4, 9 Zhang J....Noguchi E. (Pediatr Allergy Immunol 2006)
    7. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. (PubMed id 14515063)1, 4, 9 Thompson M.D....O'Dowd B.F. (Pharmacogenetics 2003)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (Hum. Genet. 2009)
    10. Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study. (PubMed id 19131661)1, 4 Bevan S....Markus H.S. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57105 HGNC: 18274 AceView: CYSLTR2 Ensembl:ENSG00000152207 euGenes: HUgn57105
    ECgene: CYSLTR2 Kegg: 57105 H-InvDB: CYSLTR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYSLTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYSLTR2 gene:
    Search GeneIP for patents involving CYSLTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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