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Aliases for CYSLTR2 Gene

Aliases for CYSLTR2 Gene

  • Cysteinyl Leukotriene Receptor 2 2 3 5
  • G-Protein Coupled Receptor GPCR21 3 4
  • G-Protein Coupled Receptor HG57 3 4
  • CYSLT2R 3 4
  • HGPCR21 3 4
  • CYSLT2 3 4
  • HPN321 3 4
  • Cysteinyl Leukotriene CysLT2 Receptor 3
  • PSEC0146 3
  • KPG_011 3
  • CysLTR2 4
  • GPCR21 3
  • HG57 3

External Ids for CYSLTR2 Gene

Previous GeneCards Identifiers for CYSLTR2 Gene

  • GC13P047280
  • GC13P043268
  • GC13P048217
  • GC13P047078
  • GC13P048178
  • GC13P049280
  • GC13P030074

Summaries for CYSLTR2 Gene

Entrez Gene Summary for CYSLTR2 Gene

  • The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYSLTR2 Gene

CYSLTR2 (Cysteinyl Leukotriene Receptor 2) is a Protein Coding gene. Diseases associated with CYSLTR2 include Uveal Melanoma and Adenoid Hypertrophy. Among its related pathways are RET signaling and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and cysteinyl leukotriene receptor activity. An important paralog of this gene is CYSLTR1.

UniProtKB/Swiss-Prot for CYSLTR2 Gene

  • Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Tocris Summary for CYSLTR2 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for CYSLTR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSLTR2 Gene

Genomics for CYSLTR2 Gene

Regulatory Elements for CYSLTR2 Gene

Enhancers for CYSLTR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G048729 1.4 FANTOM5 Ensembl ENCODE 11.8 +77.4 77436 2.6 ELF3 ARID4B DMAP1 ZNF2 THRB ZNF48 RAD21 ZNF143 KLF7 CREM FNDC3A CYSLTR2 RCBTB2 RB1 LPAR6 ITM2B GC13P048764
GH13G048600 1.3 Ensembl ENCODE dbSUPER 12.1 -52.7 -52705 1.7 ZNF133 ZNF2 ZNF366 ZNF280D ZNF398 ZNF843 ZFP69B MAFF PRDM6 GLIS1 CYSLTR2 FNDC3A RB1 LOC105370202
GH13G048726 1 ENCODE 11.9 +73.9 73924 3.1 PKNOX1 ARNT ARID4B FEZF1 YY1 ZNF143 ZNF207 ZNF548 TSHZ1 ZNF488 PPP1R26P1 CYSLTR2 FNDC3A GC13P048764
GH13G048678 0.5 ENCODE 12.8 +25.7 25731 1.3 SOX13 PRDM6 HLF MAX CYSLTR2 GC13P048764
GH13G048680 0.4 ENCODE 12.8 +27.3 27314 1.3 SPI1 CYSLTR2 GC13P048764
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYSLTR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYSLTR2 Gene

Chromosome:
13
Start:
48,653,711 bp from pter
End:
48,711,226 bp from pter
Size:
57,516 bases
Orientation:
Plus strand

Genomic View for CYSLTR2 Gene

Genes around CYSLTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSLTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSLTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSLTR2 Gene

Proteins for CYSLTR2 Gene

  • Protein details for CYSLTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS75-CLTR2_HUMAN
    Recommended name:
    Cysteinyl leukotriene receptor 2
    Protein Accession:
    Q9NS75
    Secondary Accessions:
    • Q9HCQ2

    Protein attributes for CYSLTR2 Gene

    Size:
    346 amino acids
    Molecular mass:
    39635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYSLTR2 Gene

Post-translational modifications for CYSLTR2 Gene

  • Glycosylation at Asn20, Asn26, Asn30, and isoforms=181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYSLTR2 Gene

Domains & Families for CYSLTR2 Gene

Gene Families for CYSLTR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NS75

UniProtKB/Swiss-Prot:

CLTR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CYSLTR2: view

Function for CYSLTR2 Gene

Molecular function for CYSLTR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Gene Ontology (GO) - Molecular Function for CYSLTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001631 cysteinyl leukotriene receptor activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004974 leukotriene receptor activity NAS 10913337
GO:0005515 protein binding IPI 21203429
genes like me logo Genes that share ontologies with CYSLTR2: view
genes like me logo Genes that share phenotypes with CYSLTR2: view

Human Phenotype Ontology for CYSLTR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYSLTR2 Gene

MGI Knock Outs for CYSLTR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYSLTR2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CYSLTR2 Gene

Localization for CYSLTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYSLTR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYSLTR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYSLTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYSLTR2: view

Pathways & Interactions for CYSLTR2 Gene

genes like me logo Genes that share pathways with CYSLTR2: view

Gene Ontology (GO) - Biological Process for CYSLTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10913337
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with CYSLTR2: view

No data available for SIGNOR curated interactions for CYSLTR2 Gene

Drugs & Compounds for CYSLTR2 Gene

(35) Drugs for CYSLTR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, antagonist 3
Nedocromil Approved Pharma Target, antagonist 5
Zafirlukast Approved, Investigational Pharma Antagonist, antagonist 3
BAY-u 9773 Pharma Antagonist of CysLT1/CysLT2 receptors, Dual CysLT1 and CysLT2 antagonist 0
[<sup>3</sup>H]ICI-198615 Pharma Antagonist 0

(19) Additional Compounds for CYSLTR2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidonic acid (in Tocrisolve100)
506-32-1

(5) Tocris Compounds for CYSLTR2 Gene

Compound Action Cas Number
Arachidonic acid (in Tocrisolve100) Endogenous free fatty acid (in water-soluble emulsion) 506-32-1
BAY-u 9773 Dual CysLT1 and CysLT2 antagonist 154978-38-8
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor 115104-28-4
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(2) ApexBio Compounds for CYSLTR2 Gene

Compound Action Cas Number
BAY-u 9773 Antagonist of CysLT1/CysLT2 receptors 154978-38-8
Pranlukast 103177-37-3
genes like me logo Genes that share compounds with CYSLTR2: view

Drug Products

Transcripts for CYSLTR2 Gene

Unigene Clusters for CYSLTR2 Gene

Cysteinyl leukotriene receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYSLTR2 Gene

No ASD Table

Relevant External Links for CYSLTR2 Gene

GeneLoc Exon Structure for
CYSLTR2
ECgene alternative splicing isoforms for
CYSLTR2

Expression for CYSLTR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYSLTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYSLTR2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.5), Adrenal Gland (x6.3), and Heart - Left Ventricle (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYSLTR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYSLTR2 Gene:

CYSLTR2

SOURCE GeneReport for Unigene cluster for CYSLTR2 Gene:

Hs.253706

mRNA Expression by UniProt/SwissProt for CYSLTR2 Gene:

Q9NS75-CLTR2_HUMAN
Tissue specificity: Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Evidence on tissue expression from TISSUES for CYSLTR2 Gene

  • Heart(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CYSLTR2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYSLTR2 Gene

Orthologs for CYSLTR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYSLTR2 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia CYSLTR2 34 35
  • 85.31 (n)
cow
(Bos Taurus)
Mammalia CYSLTR2 34 35
  • 83.77 (n)
rat
(Rattus norvegicus)
Mammalia Cysltr2 34
  • 78.03 (n)
mouse
(Mus musculus)
Mammalia Cysltr2 34 16 35
  • 77.27 (n)
oppossum
(Monodelphis domestica)
Mammalia CYSLTR2 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYSLTR2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYSLTR2 34 35
  • 62.19 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100002717 34
  • 49.88 (n)
CYSLTR2 35
  • 35 (a)
OneToOne
Species where no ortholog for CYSLTR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYSLTR2 Gene

ENSEMBL:
Gene Tree for CYSLTR2 (if available)
TreeFam:
Gene Tree for CYSLTR2 (if available)

Paralogs for CYSLTR2 Gene

Variants for CYSLTR2 Gene

Sequence variations from dbSNP and Humsavar for CYSLTR2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs41347648 Uncertain significance 48,707,418(+) AGACC(A/G)TGAAC reference, missense
rs1000014108 -- 48,698,190(+) TCCTC(A/G)AGAAG intron-variant
rs1000050751 -- 48,658,002(+) TAAAA(A/T)TAAGG intron-variant
rs1000091691 -- 48,686,038(+) CATGG(A/G)TTCGT intron-variant
rs1000205151 -- 48,710,430(+) TGCTT(A/G)TGTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYSLTR2 Gene

Variant ID Type Subtype PubMed ID
nsv483118 CNV gain+loss 15286789
nsv832604 CNV loss 17160897
nsv832605 CNV gain 17160897

Variation tolerance for CYSLTR2 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYSLTR2 Gene

Human Gene Mutation Database (HGMD)
CYSLTR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYSLTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYSLTR2 Gene

Disorders for CYSLTR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYSLTR2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
uveal melanoma
  • melanoma of uvea
adenoid hypertrophy
  • adenoidal hypertrophy
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYSLTR2

Genetic Association Database (GAD)
CYSLTR2
Human Genome Epidemiology (HuGE) Navigator
CYSLTR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYSLTR2
genes like me logo Genes that share disorders with CYSLTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYSLTR2 Gene

Publications for CYSLTR2 Gene

  1. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor. (PMID: 10913337) Takasaki J. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. (PMID: 18366797) Al-Shemari H. … Desrosiers M. (BMC Med. Genet. 2008) 3 22 46 64
  3. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. (PMID: 17460547) Klotsman M. … Anderson W.H. (Pharmacogenet. Genomics 2007) 3 22 46 64
  4. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. (PMID: 15970796) Park J.S. … Shin H.D. (Pharmacogenet. Genomics 2005) 3 22 46 64
  5. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. (PMID: 14515063) Thompson M.D. … O'Dowd B.F. (Pharmacogenetics 2003) 3 22 46 64

Products for CYSLTR2 Gene

Sources for CYSLTR2 Gene

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