Aliases for CYSLTR2 Gene
External Ids for CYSLTR2 Gene
Previous GeneCards Identifiers for CYSLTR2 Gene
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYSLTR2 Gene
CYSLTR2 (Cysteinyl Leukotriene Receptor 2) is a Protein Coding gene. Diseases associated with CYSLTR2 include kaposi sarcoma and leukocyte adhesion deficiency. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include leukotriene receptor activity and cysteinyl leukotriene receptor activity. An important paralog of this gene is PTAFR.
UniProtKB/Swiss-Prot for CYSLTR2 Gene
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of vascular, respiratory and gastrointestinal smooth muscle.