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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYSLTR2 Gene

protein-coding   GIFtS: 62
GCID: GC13P049280

Cysteinyl Leukotriene Receptor 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteinyl Leukotriene Receptor 21 2     hGPCR212 3
CYSLT22 3 5     HG572
CYSLT2R2 3     KPG_0112
HPN3212 3     Cysteinyl Leukotriene CysLT2 Receptor2
G-Protein Coupled Receptor GPCR212 3     G Protein-Coupled Receptor2
G-Protein Coupled Receptor HG572 3     CysLTR23

External Ids:    HGNC: 182741   Entrez Gene: 571052   Ensembl: ENSG000001522077   OMIM: 6056665   UniProtKB: Q9NS753   

Export aliases for CYSLTR2 gene to outside databases

Previous GC identifers: GC13P047280 GC13P043268 GC13P048217 GC13P047078 GC13P048178 GC13P030074


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYSLTR2 Gene:
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic
studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this
gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems
to play a major role in endocrine and cardiovascular systems. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYSLTR2 Gene: 
CYSLTR2 (cysteinyl leukotriene receptor 2) is a protein-coding gene. Diseases associated with CYSLTR2 include fainting, and kaposi's sarcoma, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include cysteinyl leukotriene receptor activity and leukotriene receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75
Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces
specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary
vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4

summary for CYSLTR2 Gene:
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4,
LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase
enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene
receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high
affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are
expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting
that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of
vascular, respiratory and gastrointestinal smooth muscle.

Gene Wiki entry for CYSLTR2 (Cysteinyl leukotriene receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYSLTR2 gene promoter:
         c-Fos   POU2F1   AP-1   POU2F1a   ATF-2   c-Jun   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYSLTR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYSLTR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYSLTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.2

CYSLTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYSLTR2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P049280:  view genomic region     (about GC identifiers)

Start:
49,280,951 bp from pter      End:
49,283,498 bp from pter
Size:
2,548 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75 (See protein sequence)
Recommended Name: Cysteinyl leukotriene receptor 2  
Size: 346 amino acids; 39635 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q9HCQ2

Explore the universe of human proteins at neXtProt for CYSLTR2: NX_Q9NS75

Explore proteomics data for CYSLTR2 at MOPED 

CYSLTR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CYSLTR2 Protein Expression

REFSEQ proteins: NP_065110.1  
ENSEMBL proteins: 
 ENSP00000282018  
Reactome Protein details: Q9NS75
Human Recombinant Protein Products for CYSLTR2: 
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Cloud-Clone Corp. Proteins for CYSLTR2 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005886plasma membrane TAS--
GO:0016020membrane ----
GO:0016021integral to membrane IEA--

CYSLTR2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LTNR: GPCR / Class A : Leukotriene receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: CysLT2 receptor 
Leukotriene receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR013311 CLT2_recept
 IPR004071 Cyst_leuk_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9NS75

ProtoNet protein and cluster: Q9NS75

1 Blocks protein domain: IPB004071 Cysteinyl leukotriene receptor family signature

UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75
Similarity: Belongs to the G-protein coupled receptor 1 family


CYSLTR2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLTR2_HUMAN, Q9NS75
Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces
specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary
vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001631cysteinyl leukotriene receptor activity IEA--
GO:0004930G-protein coupled receptor activity ----
GO:0004974leukotriene receptor activity NAS10913337
     
CYSLTR2 for ontologies           About GeneDecksing


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cysltr2):
 cardiovascular system  homeostasis/metabolism  immune system  integument  respiratory system 

CYSLTR2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Cysltr2tm1Ykn for CYSLTR2

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CYSLTR2 
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SwitchGear 3'UTR luciferase reporter plasmidCYSLTR2 3' UTR sequence
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYSLTR2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CYSLTR2 About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Prostanoid ligand receptors
Eicosanoid ligand-binding receptors0.60
Leukotriene receptors0.33
5Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for CYSLTR2
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


1 GeneGo (Thomson Reuters) Pathway for CYSLTR2
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

2 BioSystems Pathways for CYSLTR2
    GPCRs, Class A Rhodopsin-like
Endothelins

5/9        Reactome Pathways for CYSLTR2 (see all 9)
    GPCR downstream signaling
Eicosanoid ligand-binding receptors
Leukotriene receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by GPCR


2         Kegg Pathways  (Kegg details for CYSLTR2):
    Calcium signaling pathway
Neuroactive ligand-receptor interaction


CYSLTR2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYSLTR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/126 Interacting proteins for CYSLTR2 (ENSP000002820184) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
InteractantInteraction Details
GeneCardExternal ID(s)
ANXA1ENSP000002574974STRING: ENSP00000257497
AVPR1AENSP000002991784STRING: ENSP00000299178
AVPR1BENSP000003560944STRING: ENSP00000356094
CCKENSP000003356574STRING: ENSP00000335657
CIDEBENSP000003377314STRING: ENSP00000337731
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS10913337
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0010942positive regulation of cell death IEA--
GO:0045766positive regulation of angiogenesis IEA--
GO:0050909sensory perception of taste ----

CYSLTR2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYSLTR2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for CYSLTR2 available from Tocris Bioscience    About this table
CompoundAction CAS #
17-ODYALTB-omega-Hydroxylase inhibitor[34450-18-5]
MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active [128312-51-6]
LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
Leukotriene B4BLT1/BLT2 receptor agonist and potent chemotactic factor[71160-24-2]

1 HMDB Compound for CYSLTR2    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

1 DrugBank Compound for CYSLTR2    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Nedocromil-- 69049-73-6targetantagonist16164449 17139284 20558817 17016423

10/14 IUPHAR Ligands for CYSLTR2 (CysLT2 receptor) (see all 14)    About this table 
LigandTypeActionAffinityPubmed IDs
[3H]LTC4
AgonistFull agonist6.97 - 10.89547367
[3H]LTD4
AgonistFull agonist7.3 - 9.410851239
BayCysLT2
AntagonistAntagonist8.321753081
LTD4
AgonistFull agonist7.3 - 8.19547367
N-methyl LTC4
AgonistFull agonist8.0621078884
HAMI3379
AntagonistAntagonist7.4220423349
LTC4
AgonistFull agonist7.2421753081
zafirlukast
AntagonistAntagonist6.9--
iralukast
AntagonistAntagonist6.8--
BAYu9773
AntagonistAntagonist6.5 - 6.71331415

10/35 Novoseek inferred chemical compound relationships for CYSLTR2 gene (see all 35)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ltd4 76.5 7 17941281 (2), 9647602 (1), 10913337 (1), 18174606 (1)
montelukast 72.9 5 17208594 (1), 17460547 (1), 18503712 (1), 19563734 (1)
leukotriene b4 65.7 11 15544591 (2), 12787679 (1), 15869882 (1), 20097180 (1) (see all 5)
lte4 64.2 3 9647602 (1), 16304255 (1), 20201353 (1)
5-oxoete 58.8 1 16159627 (1)
gdp 43 1 16190775 (1)
pgd2 42.9 2 17154652 (1)
aequorin 39.9 1 18566482 (1)
calcium 34.6 11 12816881 (2), 15643983 (1), 15140381 (1), 16620134 (1) (see all 10)
gtp 32.8 3 16190775 (1), 10603489 (1), 12719528 (1)

Search CenterWatch for drugs/clinical trials and news about CYSLTR2 / CLTR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYSLTR2 gene: 
NM_020377.2  

Unigene Clusters for CYSLTR2:

Cysteinyl leukotriene receptor 2
Hs.253706  [show with all ESTs], Hs.614318  [show with all ESTs]
Unigene Representative Sequences: AB038269, AK291739
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000282018(uc001vck.2 uc021rjl.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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SwitchGear 3'UTR luciferase reporter plasmidCYSLTR2 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK291739.1 AY853711.1 BC096832.1 EF141523.1 EF141524.1 EF141525.1 EF141526.1 EF141527.1 
EF141528.1 EF141529.1 EF141530.1 

3 DOTS entries:

DT.75178411  DT.120795348  DT.100670790 

20 AceView cDNA sequences:

CD630089 CD630081 BX280531 CD630079 NM_020377 CD630072 BC069160 CD630069 
CD630087 CD630084 CD630086 AW235714 AB038269 CD630067 CD630077 CD630075 
CD630066 CD630074 CF147785 BX481095 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYSLTR2 expression in normal human tissues (normalized intensities)      CYSLTR2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCATTGTAC
CYSLTR2 Expression
About this image


CYSLTR2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/24 selected tissues (see all 24) fully expand
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         Leydig Cells Testis Interstitium
         seminal vesicle ; glandular cells   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
         rectum ; glandular cells   
 
 Uterus (Reproductive System)    fully expand to see all 3 entries
         uterus, post-menopause ; glandular cells   
 
 Lung (Respiratory System)    fully expand to see all 3 entries
         lung ; pneumocytes   
 
 Liver (Hepatobiliary System)    fully expand to see all 2 entries
         Hepatocytes Liver Lobule
         liver ; bile duct cells   

See CYSLTR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYSLTR2

SOURCE GeneReport for Unigene clusters: Hs.253706 Hs.614318

UniProtKB/Swiss-Prot: CLTR2_HUMAN, Q9NS75
Tissue specificity: Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood
leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle
cells

    SABiosciences Expression via Pathway-Focused PCR Array including CYSLTR2: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYSLTR2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR2 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cysltr21 , 5 cysteinyl leukotriene receptor 21, 5 77.27(n)1
73.05(a)1
  14 (38.54 cM)5
700861  NM_001162412.11  NP_001155884.11 
 730291285 
chicken
(Gallus gallus)
Aves CYSLTR21 cysteinyl leukotriene receptor 2 62.19(n)
55.41(a)
  428071  XM_425629.1  XP_425629.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1003349631 cysteinyl leukotriene receptor 1-like 51.26(n)
44.86(a)
  100334963  XM_002662545.2  XP_002662591.2 


ENSEMBL Gene Tree for CYSLTR2 (if available)
TreeFam Gene Tree for CYSLTR2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CYSLTR2 gene
P2RY42  CYSLTR12  LPAR42  P2RY22  PTAFR2  OXGR12  P2RY112  P2RY12  
GPR172  P2RY62  GPR1742  LPAR62  LPAR52  GPR1832  P2RY102  SUCNR12  
18/52 SIMAP similar genes for CYSLTR2 using alignment to 2 protein entries:     CLTR2_HUMAN (see all proteins) (see all similar genes):
KPG_011    CYSLTR1    OXGR1    P2RY1    GPR17    F2RL1
LPAR4    P2RY2    GPR34    GPR30    LPAR6    P2RY5
AGTR2    GPR183    SSTR4    CCR5    GPR68    CCR1

CYSLTR2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/251 SNPs in CYSLTR2 are shown (see all 251)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs781371371,2
F--49278977(+) CTATCG/AAGGTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1860937591,2
--49278997(+) TCCCAA/GGATGT 1 -- us2k10--------
rs1415818621,2
C--49279004(+) TGTGG-/TTTTAT 1 -- us2k10--------
rs745691641,2
F--49279244(+) TGTTTG/TGCGCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
rs753455151,2
C,F--49279246(+) TTTGGC/TGCATA 1 -- us2k11Minor allele frequency- T:0.06WA 118
rs749109731,2
C--49279307(+) TATAGC/TGTCCC 1 -- us2k10--------
rs1472420361,2
--49279471(+) GGTACA/GTAATT 1 -- us2k10--------
rs1830771191,2
--49279521(+) ATTGGC/TATATT 1 -- us2k10--------
rs1864619841,2
--49279714(+) GTGGAA/CGCTCT 1 -- us2k10--------
rs1113801051,2
C--49279734(+) TCTCTA/CTATAT 1 -- us2k12Minor allele frequency- C:0.44CSA WA 119

HapMap Linkage Disequilibrium report for CYSLTR2 (49280951 - 49283498 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CYSLTR2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832604CNV Loss17160897
nsv832605CNV Gain17160897
nsv483118CNV Complex15286789


Human Gene Mutation Database (HGMD): CYSLTR2
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CYSLTR2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605666    OMIM disorders: --

20/32 diseases for CYSLTR2 (see all 32):    About MalaCards
fainting    kaposi's sarcoma    leukocyte adhesion deficiency    traumatic brain injury
atopy    asthma    brain injury    pertussis
rabies    sleep disorder    rhinitis    leiomyoma
sinusitis    atopic dermatitis    gingivitis    atherosclerosis
allergic rhinitis    blindness    ischemia    sarcoma

2 diseases from the University of Copenhagen DISEASES database for CYSLTR2:
Asthma     Allergic rhinitis

CYSLTR2 for disorders           About GeneDecksing

10/19 Novoseek inferred disease relationships for CYSLTR2 gene (see all 19)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
asthma 50.6 36 16304255 (5), 15475736 (4), 15454733 (3), 15970796 (2) (see all 13)
asthma allergic 36.2 3 15454733 (1), 17558309 (1)
inflammation 31.1 11 17693579 (2), 18048362 (1), 18395849 (1), 20064706 (1) (see all 9)
kaposi sarcoma 30.1 4 10987301 (1), 19258523 (1), 12816350 (1), 15688008 (1)
atherosclerosis 21.2 2 12193079 (1), 12816350 (1)
atopy 19.4 1 14515063 (1)
cardiovascular diseases 13.8 1 10790351 (1)
nasal polyps 10.7 2 16689996 (1)
myocardial infarction 0 1 12816881 (1)
heart diseases 0 2 17557938 (2)

Genetic Association Database (GAD): CYSLTR2
Human Genome Epidemiology (HuGE) Navigator: CYSLTR2 (14 documents)

Export disorders for CYSLTR2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CYSLTR2 gene, integrated from 9 sources (see all 215):
(articles sorted by number of sources associating them with CYSLTR2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor. (PubMed id 10913337)1, 2, 3, 9 Takasaki J....Furuichi K. (2000)
  2. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. (PubMed id 15970796)1, 4, 9 Park J.S....Shin H.D. (2005)
  3. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. (PubMed id 17460547)1, 4, 9 Klotsman M....Anderson W.H. (2007)
  4. Characterization of the human cysteinyl leukotriene 2 receptor. (PubMed id 10851239)1, 2, 9 Heise C.E.... Evans J.F. (2000)
  5. Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. (PubMed id 18366797)1, 4, 9 Al-Shemari H....Desrosiers M. (2008)
  6. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PubMed id 16771777)1, 4, 9 Zhang J....Noguchi E. (2006)
  7. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. (PubMed id 14515063)1, 4, 9 Thompson M.D....O'Dowd B.F. (2003)
  8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  9. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (2009)
  10. Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study. (PubMed id 19131661)1, 4 Bevan S....Markus H.S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 57105 HGNC: 18274 AceView: CYSLTR2 Ensembl:ENSG00000152207 euGenes: HUgn57105
ECgene: CYSLTR2 Kegg: 57105 H-InvDB: CYSLTR2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CYSLTR2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CYSLTR2 gene:
Search GeneIP for patents involving CYSLTR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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