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Aliases for CYSLTR1 Gene

Aliases for CYSLTR1 Gene

  • Cysteinyl Leukotriene Receptor 1 2 3 5
  • Cysteinyl Leukotriene D4 Receptor 3 4
  • G-Protein Coupled Receptor HG55 3 4
  • LTD4 Receptor 3 4
  • HMTMF81 3 4
  • CYSLT1 3 4
  • CYSLT1R 3
  • CysLTR1 4
  • CYSLTR 3

External Ids for CYSLTR1 Gene

Previous GeneCards Identifiers for CYSLTR1 Gene

  • GC0XM073074
  • GC0XM074489
  • GC0XM075569
  • GC0XM076284
  • GC0XM077334
  • GC0XM077526
  • GC0XM071107

Summaries for CYSLTR1 Gene

Entrez Gene Summary for CYSLTR1 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CYSLTR1 Gene

CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include Asthma and Adenoid Hypertrophy. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for CYSLTR1 Gene

  • Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Tocris Summary for CYSLTR1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for CYSLTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSLTR1 Gene

Genomics for CYSLTR1 Gene

Regulatory Elements for CYSLTR1 Gene

Enhancers for CYSLTR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Promoters for CYSLTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYSLTR1 Gene

Chromosome:
X
Start:
78,271,464 bp from pter
End:
78,327,691 bp from pter
Size:
56,228 bases
Orientation:
Minus strand

Genomic View for CYSLTR1 Gene

Genes around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSLTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSLTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSLTR1 Gene

Proteins for CYSLTR1 Gene

  • Protein details for CYSLTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y271-CLTR1_HUMAN
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Protein Accession:
    Q9Y271
    Secondary Accessions:
    • B2R954
    • D3DTE4
    • Q5JS94
    • Q8IV19

    Protein attributes for CYSLTR1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38541 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.

neXtProt entry for CYSLTR1 Gene

Proteomics data for CYSLTR1 Gene at MOPED

Post-translational modifications for CYSLTR1 Gene

  • Glycosylation at Asn 6, Asn 169, Asn 180, and Asn 262
  • Modification sites at PhosphoSitePlus

Other Protein References for CYSLTR1 Gene

No data available for DME Specific Peptides for CYSLTR1 Gene

Domains & Families for CYSLTR1 Gene

Gene Families for CYSLTR1 Gene

Suggested Antigen Peptide Sequences for CYSLTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y271

UniProtKB/Swiss-Prot:

CLTR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CYSLTR1: view

Function for CYSLTR1 Gene

Molecular function for CYSLTR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Gene Ontology (GO) - Molecular Function for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with CYSLTR1: view
genes like me logo Genes that share phenotypes with CYSLTR1: view

Animal Models for CYSLTR1 Gene

MGI Knock Outs for CYSLTR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYSLTR1

miRNA for CYSLTR1 Gene

miRTarBase miRNAs that target CYSLTR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYSLTR1 Gene

Localization for CYSLTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYSLTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYSLTR1 Gene COMPARTMENTS Subcellular localization image for CYSLTR1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CYSLTR1: view

Pathways & Interactions for CYSLTR1 Gene

genes like me logo Genes that share pathways with CYSLTR1: view

Gene Ontology (GO) - Biological Process for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003013 circulatory system process IBA --
GO:0006952 defense response TAS 10391245
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with CYSLTR1: view

No data available for SIGNOR curated interactions for CYSLTR1 Gene

Drugs & Compounds for CYSLTR1 Gene

(33) Drugs for CYSLTR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, antagonist, Target 3
Montelukast Approved Pharma Antagonist, antagonist, Target 265
Zafirlukast Approved, Investigational Pharma Antagonist, antagonist, Target 2
Cinalukast Approved Pharma antagonist, Target Potent, selective CysLT1 (LTD4) antagonist; orally active 0
Nedocromil Approved Pharma Target, suppressor 5

(20) Additional Compounds for CYSLTR1 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
Leukotriene D4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-glycine
  • Leukotriene D
  • LTD
  • LTD4
73836-78-9
Fpl 55712
40785-97-5
LY 255283
117690-79-6
SR 2640 hydrochloride
146662-42-2

(5) Tocris Compounds for CYSLTR1 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(2) ApexBio Compounds for CYSLTR1 Gene

Compound Action Cas Number
Montelukast Sodium Leukotriene receptor antagonist 151767-02-1
Pranlukast 103177-37-3
genes like me logo Genes that share compounds with CYSLTR1: view

Drug Products

Transcripts for CYSLTR1 Gene

Unigene Clusters for CYSLTR1 Gene

Cysteinyl leukotriene receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYSLTR1 Gene

No ASD Table

Relevant External Links for CYSLTR1 Gene

GeneLoc Exon Structure for
CYSLTR1
ECgene alternative splicing isoforms for
CYSLTR1

Expression for CYSLTR1 Gene

mRNA expression in normal human tissues for CYSLTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYSLTR1 Gene

This gene is overexpressed in Esophagus - Muscularis (x9.3), Esophagus - Gastroesophageal Junction (x7.9), and Whole Blood (x4.3).

SOURCE GeneReport for Unigene cluster for CYSLTR1 Gene Hs.733809

mRNA Expression by UniProt/SwissProt for CYSLTR1 Gene

Q9Y271-CLTR1_HUMAN
Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
genes like me logo Genes that share expression patterns with CYSLTR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CYSLTR1 Gene

Orthologs for CYSLTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYSLTR1 35
  • 92.26 (n)
  • 92.26 (a)
-- 36
  • 85 (a)
OneToMany
CYSLTR1 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYSLTR1 35
  • 91.77 (n)
  • 93.75 (a)
CYSLTR1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cysltr1 35
  • 87.56 (n)
  • 88.06 (a)
Cysltr1 16
Cysltr1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYSLTR1 35
  • 99.13 (n)
  • 98.7 (a)
CYSLTR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cysltr1 35
  • 86.83 (n)
  • 86.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CYSLTR1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYSLTR1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYSLTR1 35
  • 66.36 (n)
  • 68.83 (a)
CYSLTR1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYSLTR1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cysltr1 35
  • 65.72 (n)
  • 65.82 (a)
zebrafish
(Danio rerio)
Actinopterygii cysltr1 35
  • 62.24 (n)
  • 60.76 (a)
Dr.26064 35
cysltr1 36
  • 56 (a)
OneToOne
Species with no ortholog for CYSLTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYSLTR1 Gene

ENSEMBL:
Gene Tree for CYSLTR1 (if available)
TreeFam:
Gene Tree for CYSLTR1 (if available)

Paralogs for CYSLTR1 Gene

genes like me logo Genes that share paralogs with CYSLTR1: view

Variants for CYSLTR1 Gene

Sequence variations from dbSNP and Humsavar for CYSLTR1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747700915 -- 78,292,443(+) GTATT(A/C)TGTGG intron-variant
rs747709225 -- 78,301,027(+) GCCTA(A/C)GCTGT intron-variant
rs747712783 -- 78,278,302(+) ATTGG(C/T)ATCCC intron-variant
rs747724221 -- 78,272,393(+) ATTGA(C/G)TAATT utr-variant-3-prime
rs747762878 -- 78,273,077(+) CAGAT(A/T)TTTTT reference, missense

Variation tolerance for CYSLTR1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYSLTR1 Gene

Human Gene Mutation Database (HGMD)
CYSLTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYSLTR1 Gene

Disorders for CYSLTR1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CYSLTR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
adenoid hypertrophy
  • adenoidal hypertrophy
rhinitis
  • runny nose
sinusitis
bronchial disease
  • bronchospasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYSLTR1

Genetic Association Database (GAD)
CYSLTR1
Human Genome Epidemiology (HuGE) Navigator
CYSLTR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYSLTR1
genes like me logo Genes that share disorders with CYSLTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYSLTR1 Gene

Publications for CYSLTR1 Gene

  1. Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PMID: 10391245) Lynch K.R. … Evans J.F. (Nature 1999) 2 3 4 23 67
  2. Distribution of specific binding sites for cysteinyl leukotriene 1 receptor antagonist in human nasal mucosa. (PMID: 16864492) Shirasaki H. … Himi T. (Acta Otolaryngol. 2006) 23 25 26
  3. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. (PMID: 11854273) Ogasawara H. … Izumi T. (J. Biol. Chem. 2002) 23 25 26
  4. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PMID: 10462554) Sarau H.M. … Hay D.W.P. (Mol. Pharmacol. 1999) 2 3 23
  5. Leukotrienes in the pathogenesis of asthma. (PMID: 9042024) O'Byrne P.M. (Chest 1997) 23 25 26

Products for CYSLTR1 Gene

Sources for CYSLTR1 Gene

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