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Aliases for CYSLTR1 Gene

Aliases for CYSLTR1 Gene

  • Cysteinyl Leukotriene Receptor 1 2 3 5
  • Cysteinyl Leukotriene D4 Receptor 3 4
  • G-Protein Coupled Receptor HG55 3 4
  • LTD4 Receptor 3 4
  • HMTMF81 3 4
  • CYSLT1 3 4
  • CYSLT1R 3
  • CysLTR1 4
  • CYSLTR 3

External Ids for CYSLTR1 Gene

Previous GeneCards Identifiers for CYSLTR1 Gene

  • GC0XM073074
  • GC0XM074489
  • GC0XM075569
  • GC0XM076284
  • GC0XM077334
  • GC0XM077526
  • GC0XM071107

Summaries for CYSLTR1 Gene

Entrez Gene Summary for CYSLTR1 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CYSLTR1 Gene

CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include Asthma and Adenoid Hypertrophy. Among its related pathways are RET signaling and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is CYSLTR2.

UniProtKB/Swiss-Prot for CYSLTR1 Gene

  • Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Tocris Summary for CYSLTR1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for CYSLTR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSLTR1 Gene

Genomics for CYSLTR1 Gene

Regulatory Elements for CYSLTR1 Gene

Enhancers for CYSLTR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG078102 1.1 ENCODE 8.9 +222.6 222637 4.6 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 TAF9B CYSLTR1 FGF16 GC0XP078105 GC0XP078104 GC0XM078132 GC0XM078131 GC0XM078130
GH0XG078325 0.6 ENCODE 12.8 -0.7 -739 5.8 NR2F1 ZNF10 JUNB EBF1 ZNF507 CBX5 IKZF1 CHD2 TAF9B CYSLTR1 FGF16 HMGN1P34
GH0XG078652 1.4 FANTOM5 Ensembl ENCODE 3.6 -325.6 -325609 2.4 FOXA2 JUN RARA YY1 HNF4G FOS NR2F6 RELB IKZF2 MIXL1 TAF9B CYSLTR1 RTL3 UBE2V1P7
GH0XG078516 0.7 ENCODE 5.2 -189.7 -189745 1.5 TBL1XR1 ARID3A EED ETV6 RELB IKZF2 CREM SRF MTA2 ZBED1 CYSLTR1 HMGN1P34
GH0XG078073 0.4 ENCODE 8.6 +254.1 254126 0.5 NFYB CYSLTR1 FGF16 GC0XM078066 GC0XP078104 GC0XP078105
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Promoters for CYSLTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247345 691 1601 CBX5 NR2F1 IKZF1 IKZF2 CHD2

Genomic Location for CYSLTR1 Gene

Chromosome:
X
Start:
78,271,464 bp from pter
End:
78,327,691 bp from pter
Size:
56,228 bases
Orientation:
Minus strand

Genomic View for CYSLTR1 Gene

Genes around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSLTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSLTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSLTR1 Gene

Proteins for CYSLTR1 Gene

  • Protein details for CYSLTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y271-CLTR1_HUMAN
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Protein Accession:
    Q9Y271
    Secondary Accessions:
    • B2R954
    • D3DTE4
    • Q5JS94
    • Q8IV19

    Protein attributes for CYSLTR1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38541 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.

neXtProt entry for CYSLTR1 Gene

Post-translational modifications for CYSLTR1 Gene

  • Glycosylation at isoforms=6, Asn169, Asn180, and Asn262
  • Modification sites at PhosphoSitePlus

Other Protein References for CYSLTR1 Gene

No data available for DME Specific Peptides for CYSLTR1 Gene

Domains & Families for CYSLTR1 Gene

Gene Families for CYSLTR1 Gene

Suggested Antigen Peptide Sequences for CYSLTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y271

UniProtKB/Swiss-Prot:

CLTR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CYSLTR1: view

Function for CYSLTR1 Gene

Molecular function for CYSLTR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Gene Ontology (GO) - Molecular Function for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004974 leukotriene receptor activity TAS,IEA --
GO:0005515 protein binding IPI 21203429
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with CYSLTR1: view
genes like me logo Genes that share phenotypes with CYSLTR1: view

Animal Models for CYSLTR1 Gene

MGI Knock Outs for CYSLTR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYSLTR1

miRNA for CYSLTR1 Gene

miRTarBase miRNAs that target CYSLTR1

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for CYSLTR1 (Cysteinyl Leukotriene R1/CysLTR1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYSLTR1 Gene

Localization for CYSLTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYSLTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYSLTR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,TAS --
GO:0016020 membrane TAS 10391245
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYSLTR1: view

Pathways & Interactions for CYSLTR1 Gene

genes like me logo Genes that share pathways with CYSLTR1: view

Gene Ontology (GO) - Biological Process for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0003013 circulatory system process IBA --
GO:0006816 calcium ion transport IEA --
GO:0006935 chemotaxis IEA --
GO:0006952 defense response TAS 10391245
genes like me logo Genes that share ontologies with CYSLTR1: view

No data available for SIGNOR curated interactions for CYSLTR1 Gene

Drugs & Compounds for CYSLTR1 Gene

(40) Drugs for CYSLTR1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, antagonist, Target 3
Zafirlukast Approved, Investigational Pharma Antagonist, antagonist, Target 3
Montelukast Approved Pharma Antagonist, antagonist, Target 270
Cinalukast Approved Pharma antagonist, Target 0
Nedocromil Approved Pharma Target, suppressor 5

(16) Additional Compounds for CYSLTR1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene D4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-glycine
  • Leukotriene D
  • LTD
  • LTD4
  • (R-(R*,s*-(e,e,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine
73836-78-9
Arachidonic acid (in Tocrisolve100)
506-32-1

(5) Tocris Compounds for CYSLTR1 Gene

Compound Action Cas Number
Arachidonic acid (in Tocrisolve100) Endogenous free fatty acid (in water-soluble emulsion) 506-32-1
BAY-u 9773 Dual CysLT1 and CysLT2 antagonist 154978-38-8
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor 115104-28-4
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(6) ApexBio Compounds for CYSLTR1 Gene

Compound Action Cas Number
BAY-u 9773 Antagonist of CysLT1/CysLT2 receptors 154978-38-8
MK 571 leukotriene D4 receptor antagonist, orally active 115104-28-4
MK-571 sodium salt hydrate 115103-85-0
Montelukast Sodium Leukotriene receptor antagonist 151767-02-1
Pranlukast 103177-37-3
Zafirlukast 107753-78-6
genes like me logo Genes that share compounds with CYSLTR1: view

Drug Products

Transcripts for CYSLTR1 Gene

Unigene Clusters for CYSLTR1 Gene

Cysteinyl leukotriene receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for CYSLTR1 (Cysteinyl Leukotriene R1/CysLTR1)

Alternative Splicing Database (ASD) splice patterns (SP) for CYSLTR1 Gene

No ASD Table

Relevant External Links for CYSLTR1 Gene

GeneLoc Exon Structure for
CYSLTR1
ECgene alternative splicing isoforms for
CYSLTR1

Expression for CYSLTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYSLTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYSLTR1 Gene

This gene is overexpressed in Esophagus - Muscularis (x9.3), Esophagus - Gastroesophageal Junction (x7.9), and Whole Blood (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of CYSLTR1 Gene:

CYSLTR1

SOURCE GeneReport for Unigene cluster for CYSLTR1 Gene:

Hs.733809

mRNA Expression by UniProt/SwissProt for CYSLTR1 Gene:

Q9Y271-CLTR1_HUMAN
Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

Evidence on tissue expression from TISSUES for CYSLTR1 Gene

  • Blood(4.4)
  • Spleen(4.3)
  • Pancreas(4)
  • Lung(2.7)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with CYSLTR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYSLTR1 Gene

Orthologs for CYSLTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYSLTR1 34 35
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia CYSLTR1 34 35
  • 92.26 (n)
-- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYSLTR1 34 35
  • 91.77 (n)
mouse
(Mus musculus)
Mammalia Cysltr1 34 16 35
  • 87.56 (n)
rat
(Rattus norvegicus)
Mammalia Cysltr1 34
  • 86.83 (n)
oppossum
(Monodelphis domestica)
Mammalia CYSLTR1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYSLTR1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYSLTR1 34 35
  • 66.36 (n)
lizard
(Anolis carolinensis)
Reptilia CYSLTR1 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cysltr1 34
  • 65.72 (n)
zebrafish
(Danio rerio)
Actinopterygii cysltr1 34 35
  • 62.24 (n)
Dr.26064 34
Species where no ortholog for CYSLTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYSLTR1 Gene

ENSEMBL:
Gene Tree for CYSLTR1 (if available)
TreeFam:
Gene Tree for CYSLTR1 (if available)

Paralogs for CYSLTR1 Gene

genes like me logo Genes that share paralogs with CYSLTR1: view

Variants for CYSLTR1 Gene

Sequence variations from dbSNP and Humsavar for CYSLTR1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs193920986 Uncertain significance 78,273,679(-) CCGCA(-/A)TCAAG reference, frameshift-variant
rs1000021866 -- 78,312,845(+) AAGAG(A/G)GTGCT intron-variant
rs1000033134 -- 78,312,534(+) AAATA(C/T)ACAGC intron-variant
rs1000148060 -- 78,315,044(+) AGTGG(A/G)GAGGA intron-variant
rs1000164127 -- 78,303,619(+) CTGTA(C/T)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYSLTR1 Gene

Variant ID Type Subtype PubMed ID
esv3574111 CNV loss 25503493

Variation tolerance for CYSLTR1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYSLTR1 Gene

Human Gene Mutation Database (HGMD)
CYSLTR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYSLTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYSLTR1 Gene

Disorders for CYSLTR1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CYSLTR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
adenoid hypertrophy
  • adenoidal hypertrophy
rhinitis
  • runny nose
sinusitis
bronchial disease
  • bronchospasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYSLTR1

Genetic Association Database (GAD)
CYSLTR1
Human Genome Epidemiology (HuGE) Navigator
CYSLTR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYSLTR1
genes like me logo Genes that share disorders with CYSLTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYSLTR1 Gene

Publications for CYSLTR1 Gene

  1. Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PMID: 10391245) Lynch K.R. … Evans J.F. (Nature 1999) 2 3 4 22 64
  2. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PMID: 10462554) Sarau H.M. … Hay D.W.P. (Mol. Pharmacol. 1999) 2 3 4 22 64
  3. Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity. (PMID: 19450127) York T.P. … van den Oord E.J. (Pharmacogenomics 2009) 3 22 46 64
  4. 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira K.G. … Weiss S.T. (Pharmacogenet. Genomics 2009) 3 22 46 64
  5. Variable expression of cysteinyl leukotriene type I receptor splice variants in asthmatic females with different promoter haplotypes. (PMID: 20003473) Sokolowska M. … Pawliczak R. (BMC Immunol. 2009) 3 22 46 64

Products for CYSLTR1 Gene

Sources for CYSLTR1 Gene

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