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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYSLTR1 Gene

protein-coding GIFtS: 64
GCID: GC0XM077526

cysteinyl leukotriene receptor 1

Explore 42 diseases affiliated with
CYSLTR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cysteinyl Leukotriene Receptor 1¹ ²		LTD4 Receptor² ³
CYSLT1² ³ ⁵		CysLT(1)¹
CYSLT1R¹ ²		CysLT1¹
Cysteinyl Leukotriene D4 Receptor² ³		CYSLTR²
HMTMF81² ³		HG55²
G-Protein Coupled Receptor HG55² ³		CysLTR1³

External Ids:	HGNC: 17451¹	Entrez Gene: 10800²	Ensembl: ENSG00000173198⁷	OMIM: 300201⁵	UniProtKB: Q9Y271³

Export aliases for CYSLTR1 gene to outside databases

Previous GC identifers: GC0XM073074 GC0XM074489 GC0XM075569 GC0XM076284 GC0XM077334 GC0XM071107

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYSLTR1:

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic

studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene

and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this

receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to

the mucus layer in the lung. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271

Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma.

Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and

damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a

phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >>

LTE4 = LTC4 >> LTB4

summary for CYSLTR1:

Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4,

LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase

enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene

receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high

affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are

expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting

that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of

vascular, respiratory and gastrointestinal smooth muscle.

Gene Wiki entry for CYSLTR1 (Cysteinyl leukotriene receptor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011651.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYSLTR1 gene promoter:
E2F-4 E2F-3a E2F-5 FOXF2 AP-1 ATF-2 E2F-2 E2F E2F-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYSLTR1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYSLTR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYSLTR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2-q21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq13-q21

CYSLTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYSLTR1 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM077526: view genomic region (about GC identifiers)

Start:	77,526,961 bp from pter	End:	77,583,087 bp from pter
Size:	56,127 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271 (See protein sequence)

Recommended Name: Cysteinyl leukotriene receptor 1

Size: 337 amino acids; 38541 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Miscellaneous: Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon),

are used in the treatment of the asthma crisis

Secondary accessions: B2R954 D3DTE4 Q5JS94 Q8IV19

Explore the universe of human proteins at neXtProt for CYSLTR1: NX_Q9Y271

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y271

CYSLTR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006630.1

ENSEMBL proteins:

ENSP00000362401

Reactome Protein details: Q9Y271
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CYSLTR1 Protein
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	Uscn Proteins for CYSLTR1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0016020	membrane	TAS	10391245

CYSLTR1 for ontologies About GeneDecksing

CYSLTR1 Antibody Products:

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Assay Products for CYSLTR1:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYSLTR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYSLTR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR013310 CLT1_recept

IPR004071 Cyst_leuk_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9Y271

ProtoNet protein and cluster: Q9Y271

1 Blocks protein family: IPB004071 Cysteinyl leukotriene receptor family signature

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271

Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma.

Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and

damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a

phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >>

LTE4 = LTC4 >> LTB4

miRNA Products:		OriGene 3'-UTR Clone: CYSLTR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYSLTR1
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYSLTR1 (see all 7) OriGene shRNA RFP: CYSLTR1 OriGene siRNA: CYSLTR1
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		GenScript: all cDNA clones in your preferred vector: CYSLTR1 (NM_006639)
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Cell Line Products:		GenScript CYSLTR1-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for CYSLTR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYSLTR1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004974	leukotriene receptor activity	IEA	--

CYSLTR1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cysltr1^tm1Ykn for CYSLTR1
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cysltr1):

cardiovascular system

cellular

immune system

respiratory system

CYSLTR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Prostanoid ligand receptors

Eicosanoid ligand-binding receptors

0.60

Leukotriene receptors

0.00

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CYSLTR1

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1 GeneGo (Thomson Reuters) Pathway for CYSLTR1

Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

2 BioSystems Pathways for CYSLTR1

	GPCRs, Class A Rhodopsin-like
	Endothelins

5/9 Reactome Pathways for CYSLTR1 (see all 9)

	GPCR downstream signaling
	Eicosanoid ligand-binding receptors
	Leukotriene receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR

1 PharmGKB Pathway for CYSLTR1

Leukotriene modifiers pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for CYSLTR1):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction

CYSLTR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYSLTR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/125 Interacting proteins for CYSLTR1 (ENSP00000362401⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 125)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRA1B	ENSP00000306662⁴	STRING: ENSP00000306662
ADRBK1	ENSP00000312262⁴	STRING: ENSP00000312262
AVPR1B	ENSP00000356094⁴	STRING: ENSP00000356094
BDKRB2	ENSP00000307713⁴	STRING: ENSP00000307713
CCKAR	ENSP00000295589⁴	STRING: ENSP00000295589

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006816	calcium ion transport	IEA	--
GO:0006935	chemotaxis	IEA	--
GO:0006952	defense response	TAS	10391245
GO:0006954	inflammatory response	IEA	--
GO:0007166	cell surface receptor signaling pathway	--	--

CYSLTR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYSLTR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CYSLTR1

Compounds for CYSLTR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
ONO 1078	Selective CysLT1 antagonist	[103177-37-3]
BAY-u 9773	Dual CysLT1 and CysLT2 antagonist	[154978-38-8]
Cinalukast	Potent, selective CysLT1 (LTD4) antagonist; orally active	[128312-51-6]
MK 571	Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor	[115104-28-4]

2 HMDB Compounds for CYSLTR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Leukotriene D4	LTD (see all 4)	73836-78-9	--

5 DrugBank Compounds for CYSLTR1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Montelukast	--	158966-92-8	target	antagonist	15456537 17199874 16815057 16815146 15013935 11752352
Pranlukast	--	103177-37-3	target	antagonist	17112405 11264758 11854273 15475658 11752352 16864492
Zafirlukast	--	107753-78-6	target	antagonist	11006272 11061985 9042024 10851239 11752352 11979731
Nedocromil	--	69049-73-6	target	suppressor	16164449 17139284 20558817 8386571 17016423
Cinalukast	--	128312-51-6	target	antagonist	9042047 11752352 19826192

10/33 Novoseek chemical compound relationships for CYSLTR1 gene (see all 33) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ltd4	95.7	137	1645886 (4), 1313876 (3), 9118902 (3), 1323587 (3) (see all 68)
pranlukast	92.8	32	8887574 (2), 11527250 (2), 17443897 (2), 15650315 (2) (see all 19)
montelukast	92.8	54	18332235 (3), 17883728 (3), 18566548 (2), 18946234 (2) (see all 32)
pobilukast	88.4	2	10462554 (1), 8298810 (1)
zafirlukast	85.9	7	9042024 (1), 10462554 (1), 11888331 (1), 12735786 (1) (see all 6)
ym-158	84.7	3	10887942 (1)
ltc4	83.2	17	1678589 (2), 9042024 (1), 7842366 (1), 17397245 (1) (see all 10)
ly171883	82.8	3	8298810 (1), 2175680 (1)
mk 571	79.3	6	11438743 (1), 1611229 (1), 18028998 (1), 13679572 (1) (see all 5)
lte4	76.2	4	16304255 (1), 16776674 (1), 1323587 (1)

Search CenterWatch for drugs/clinical trials and news about CYSLTR1 / CLTR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYSLTR1 gene:

NM_006639.2

Unigene Cluster for CYSLTR1:

Cysteinyl leukotriene receptor 1

Hs.733809 [show with all ESTs]

Unigene Representative Sequence: NM_006639

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373304(uc004edb.3 uc010nma.3 uc010nmb.3) ENST00000493254

miRNA Products:		OriGene 3'-UTR Clone: CYSLTR1 Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYSLTR1 (see all 7) OriGene shRNA RFP: CYSLTR1 OriGene siRNA: CYSLTR1
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYSLTR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYSLTR1

Additional cDNA sequence:

AF119711.1 AF133266.1 AK313643.1 BC035750.1 DQ131799.1 DQ131800.1 DQ131801.1 DQ131802.1

DQ131803.1

2 DOTS entries:

DT.105970 DT.121289365

24/35 AceView cDNA sequences (see all 35):

AF133266 CK903387 AF119711 AA737451 NM_006639 BM920299 BX106054 BQ880456

AU141814 AI215416 CF147786 CK903386 AI948890 AA865828 AA906003 BM955973

BC035750 CD701219 BE549540 AK023929 BE504249 AA831526 AA761471 BV192244

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYSLTR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATATGTTTA

About this image

CYSLTR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYSLTR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYSLTR1

SOURCE GeneReport for Unigene cluster: Hs.733809

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271

Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression

in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small

intestine, pancreas, colon and heart

SABiosciences Expression via Pathway-Focused PCR Arrays including CYSLTR1:

G Protein Coupled Receptors 384HT in human mouse rat

Allergy & Asthma in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYSLTR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYSLTR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYSLTR1¹	cysteinyl leukotriene receptor 1	66.36(n) 68.83(a)		428691 XM_426249.3 XP_426249.2
lizard (Anolis carolinensis)	Reptilia	CYSLTR1⁶	--	56(a)	1 ↔ 1	GL343202.1(2185221-2187114)
zebrafish (Danio rerio)	Actinopterygii	Dr.26064²	Transcribed sequence with moderate similarity to protein more	73.37(n)		CD604109.1

ENSEMBL Gene Tree for CYSLTR1 (if available)
TreeFam Gene Tree for CYSLTR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYSLTR1 gene

OXGR1² P2RY4² GPR17² P2RY1² P2RY11² P2RY6² GPR174² LPAR6²

LPAR5² GPR183² LPAR4² CYSLTR2² P2RY10² SUCNR1² P2RY2² PTAFR²

18/41 SIMAP similar genes for CYSLTR1 using alignment to 1 protein entry: CLTR1_HUMAN(see all similar genes):

CYSLTR2 KPG_011 LPAR6 P2RY5 GPR17 CX3CR1

GPR183 P2RY1 CMKLR1 PTAFR CCR6 GPR34

SUCNR1 XCR1 gpcr GPR174 LPAR4 OPRK1

CYSLTR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186575654^1,2		--	77527910(+)	`TTATCA/GTTTGT`	1	--	ds500¹		0	--	--	--	--
rs149995801^1,2	C,	--	77528255(+)	`CTCCTC/TTTTCT`	2	K R	mis¹		0	--	--	--	--
rs145713397^1,2	C,F,	--	77528271(+)	`AGAGGC/TCTTCT`	2	T A	mis¹		1		NA	4234
rs320995^1,2	C,F,A,H,	--	77528317(-)	`ACATTA/C/TAGAAA`	3	L F	mis¹ syn¹		23		MN NS EA NA WA CSA	6905
rs142993207^1,2	C,F	--	77528335(+)	`CTTTTC/TCTAAA`	2	R	syn¹		1		NA	4430
rs199725327^1,2		--	77528336(+)	`TTTTCC/GTAAAG`	2	T R	mis¹		0	--	--	--	--
rs191425988^1,2	C,	--	77528415(+)	`GACCAA/CGGACT`	2	V L	mis¹		0	--	--	--	--
rs148732852^1,2	C,	--	77528510(+)	`TGAAAC/GTGACT`	2	T S	mis¹		1		NA	4532
rs138981290^1,2	C	--	77528554(+)	`ATAGCC/TTTTTT`	2	K	syn¹		1		NA	4488
rs144735906^1,2	C,	--	77528620(+)	`GTGTAA/GCAGAC`	2	C	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYSLTR1 (77526961 - 77583087 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYSLTR1: --
Human Gene Mutation Database (HGMD): CYSLTR1

Locus Specific Mutation Databases (LSDB): CYSLTR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYSLTR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CYSLTR1 for disorders           About GeneDecksing

OMIM gene information: 300201    OMIM disorders: --

20/42 diseases for CYSLTR1 (see all 42):    About MalaCards

churg-strauss syndrome asthma bronchial asthma brain injury

traumatic brain injury non-hodgkin lymphoma sleep apnea monocytic leukemia

b-cell lymphomas eosinophilia allergic rhinitis hodgkin's lymphoma

pulmonary fibrosis pulmonary eosinophilia atopic dermatitis rhinitis

apnea epithelial ovarian cancer atopy ulcerative colitis

1 disease from the University of Copenhagen DISEASES database for CYSLTR1:

Asthma

10/22 Novoseek disease relationships for CYSLTR1 gene (see all 22) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	77.3	78	20003473 (4), 16771777 (4), 16304255 (3), 16776674 (3) (see all 36)
asthma exercise-induced	55.1	1	17883728 (1)
monocytic leukemia	48.9	1	9478929 (1)
nasal polyps	47.9	3	16739673 (1), 16689996 (1)
churg-strauss syndrome	46.5	3	10335014 (2), 12735786 (1)
inflammation	41.1	9	18048362 (1), 17693579 (1), 15650315 (1), 18606091 (1) (see all 8)
eosinophilia	31	2	8887574 (2)
ischemic brain injury	29	4	16756959 (1), 16650938 (1)
sinusitis	26.9	1	20126572 (1)
rhinitis	26	6	16771777 (4), 1964905 (1)

Genetic Association Database (GAD): CYSLTR1
Human Genome Epidemiology (HuGE) Navigator: CYSLTR1 (31 documents)

Export disorders for CYSLTR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYSLTR1 gene, integrated from 9 sources (see all 256):
(articles sorted by number of sources associating them with CYSLTR1)

Utopia: connect your pdf to the dynamic
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Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PubMed id 10391245)^{1, 2, 3, 9} Lynch K.R.... Evans J.F. (1999)
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PubMed id 10462554)^{1, 2, 3, 9} Sarau H.M....Hay D.W. (1999)
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PubMed id 14749922)^{1, 4, 9} Choi J.H....Shin H.D. (2004)
Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. (PubMed id 16293801)^{1, 4, 9} Lima J.J....Barnes K. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Overexpression of cysteinyl LT1 receptor in prostate cancer and CysLT1R antagonist inhibits prostate cancer cell growth through apoptosis. (PubMed id 17549353)^{1, 9} Matsuyama M....Yoshimura R. (2007)
Variable expression of cysteinyl leukotriene type I r eceptor splice variants in asthmatic females with different promoter haplotypes . (PubMed id 20003473)^{1, 9} Sokolowska M....Pawliczak R. (2009)
Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PubMed id 16771777)^{1, 9} Zhang J....Noguchi E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10800	HGNC: 17451	AceView: CYSLTR1	Ensembl:ENSG00000173198	euGenes: HUgn10800
ECgene: CYSLTR1	Kegg: 10800	H-InvDB: CYSLTR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYSLTR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYSLTR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYSLTR1 gene:
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CYSLTR1 Gene

cysteinyl leukotriene receptor 1

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Asthma Exercise-Induced
Sinusitis
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atopy
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Eosinophilia
Inflammation
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Monocytic leukemia
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CYSLTR1 Gene

cysteinyl leukotriene receptor 1

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