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Aliases for CYSLTR1 Gene

Aliases for CYSLTR1 Gene

  • Cysteinyl Leukotriene Receptor 1 2 3
  • CYSLT1 3 4 6
  • Cysteinyl Leukotriene D4 Receptor 3 4
  • G-Protein Coupled Receptor HG55 3 4
  • LTD4 Receptor 3 4
  • HMTMF81 3 4
  • CYSLT1R 3
  • CysLTR1 4
  • CYSLTR 3

External Ids for CYSLTR1 Gene

Summaries for CYSLTR1 Gene

Entrez Gene Summary for CYSLTR1 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CYSLTR1 Gene

CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include churg-strauss syndrome and asthma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include leukotriene receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for CYSLTR1 Gene

  • Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4

Tocris Summary for CYSLTR1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of vascular, respiratory and gastrointestinal smooth muscle.

Gene Wiki entry for CYSLTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSLTR1 Gene

Genomics for CYSLTR1 Gene

Genomic Location for CYSLTR1 Gene

Start:
78,271,464 bp from pter
End:
78,327,691 bp from pter
Size:
56,228 bases
Orientation:
Minus strand

Genomic View for CYSLTR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYSLTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSLTR1 Gene

Regulatory Elements for CYSLTR1 Gene

Proteins for CYSLTR1 Gene

  • Protein details for CYSLTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y271-CLTR1_HUMAN
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Protein Accession:
    Q9Y271
    Secondary Accessions:
    • B2R954
    • D3DTE4
    • Q5JS94
    • Q8IV19

    Protein attributes for CYSLTR1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38541 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis

neXtProt entry for CYSLTR1 Gene

Proteomics data for CYSLTR1 Gene at MOPED

Post-translational modifications for CYSLTR1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn6, Asn169, Asn180, and Asn262

Other Protein References for CYSLTR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYSLTR1 Gene

Domains for CYSLTR1 Gene

Gene Families for CYSLTR1 Gene

HGNC:
  • LTNR :GPCR / Class A : Leukotriene receptors
IUPHAR :

UniProtKB/Swiss-Prot:

CLTR1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9Y271
genes like me logo Genes that share domains with CYSLTR1: view

Function for CYSLTR1 Gene

Molecular function for CYSLTR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4

Gene Ontology (GO) - Molecular Function for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004974 leukotriene receptor activity IEA --
GO:0005515 protein binding IPI 21203429
genes like me logo Genes that share ontologies with CYSLTR1: view
genes like me logo Genes that share phenotypes with CYSLTR1: view

Animal Models for CYSLTR1 Gene

MGI Knock Outs for CYSLTR1:

miRNA for CYSLTR1 Gene

miRTarBase miRNAs that target CYSLTR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CYSLTR1 Gene

Localization for CYSLTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYSLTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYSLTR1 Gene COMPARTMENTS Subcellular localization image for CYSLTR1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 10391245
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CYSLTR1: view

Pathways for CYSLTR1 Gene

genes like me logo Genes that share pathways with CYSLTR1: view

Pathways by source for CYSLTR1 Gene

Gene Ontology (GO) - Biological Process for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
GO:0006935 chemotaxis IEA --
GO:0006952 defense response TAS 10391245
GO:0006954 inflammatory response IEA --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with CYSLTR1: view

Compounds for CYSLTR1 Gene

(5) Tocris Compounds for CYSLTR1 Gene

Compound Action Cas Number
17-ODYA LTB-omega-Hydroxylase inhibitor [34450-18-5]
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active [128312-51-6]
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor [71160-24-2]
LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor [115104-28-4]

(2) HMDB Compounds for CYSLTR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Leukotriene D4
  • LTD
73836-78-9

(5) Drugbank Compounds for CYSLTR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cinalukast
128312-51-6 target antagonist
Montelukast
158966-92-8 target antagonist
Nedocromil
69049-73-6 target suppressor
Pranlukast
103177-37-3 target antagonist
Zafirlukast
107753-78-6 target antagonist

(17) IUPHAR Ligand for CYSLTR1 Gene

Ligand Type Action Affinity Pubmed IDs
LTC4 Agonist Agonist 9.48
[3H]LTD4 Agonist Full agonist 9.4
SR2640 Antagonist Antagonist 8.7
ICI198615 Antagonist Antagonist 8.6
montelukast Antagonist Antagonist 8.55
LTD4 Agonist Agonist 8.36
sulukast Antagonist Antagonist 8.3
BayCysLT2 Antagonist Antagonist 8.3
N-methyl LTC4 Agonist Full agonist 8.06
verlukast Antagonist Antagonist 8
zafirlukast Antagonist Antagonist 6.9
iralukast Antagonist Antagonist 6.8
BAYu9773 Antagonist Antagonist 6.7
LTE4 Agonist Partial agonist 6.5
pobilukast Antagonist Antagonist 6.2
pranlukast Antagonist Antagonist 5.44
[3H]ICI-198615 Antagonist Antagonist 5.2

(33) Novoseek inferred chemical compound relationships for CYSLTR1 Gene

Compound -log(P) Hits PubMed IDs
ltd4 95.7 94
pranlukast 92.8 23
montelukast 92.8 38
pobilukast 88.4 2
zafirlukast 85.9 6
genes like me logo Genes that share compounds with CYSLTR1: view

Transcripts for CYSLTR1 Gene

Unigene Clusters for CYSLTR1 Gene

Cysteinyl leukotriene receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYSLTR1 Gene

No ASD Table

Relevant External Links for CYSLTR1 Gene

GeneLoc Exon Structure for
CYSLTR1
ECgene alternative splicing isoforms for
CYSLTR1

Expression for CYSLTR1 Gene

mRNA expression in normal human tissues for CYSLTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYSLTR1 Gene

This gene is overexpressed in Esophagus - Muscularis (9.3), Esophagus - Gastroesophageal Junction (7.9), and Whole Blood (4.3).

SOURCE GeneReport for Unigene cluster for CYSLTR1 Gene Hs.733809

mRNA Expression by UniProt/SwissProt for CYSLTR1 Gene

Q9Y271-CLTR1_HUMAN
Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart
genes like me logo Genes that share expressions with CYSLTR1: view

Orthologs for CYSLTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYSLTR1 36
  • 99.13 (n)
  • 98.7 (a)
CYSLTR1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 85 (a)
OneToMany
CYSLTR1 36
  • 92.26 (n)
  • 92.26 (a)
CYSLTR1 37
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYSLTR1 36
  • 91.77 (n)
  • 93.75 (a)
CYSLTR1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cysltr1 36
  • 87.56 (n)
  • 88.06 (a)
Cysltr1 16
Cysltr1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYSLTR1 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYSLTR1 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cysltr1 36
  • 86.83 (n)
  • 86.83 (a)
chicken
(Gallus gallus)
Aves CYSLTR1 36
  • 66.36 (n)
  • 68.83 (a)
CYSLTR1 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYSLTR1 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cysltr1 36
  • 65.72 (n)
  • 65.82 (a)
zebrafish
(Danio rerio)
Actinopterygii cysltr1 36
  • 62.24 (n)
  • 60.76 (a)
cysltr1 37
  • 56 (a)
OneToOne
Dr.26064 36
Species with no ortholog for CYSLTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYSLTR1 Gene

ENSEMBL:
Gene Tree for CYSLTR1 (if available)
TreeFam:
Gene Tree for CYSLTR1 (if available)

Paralogs for CYSLTR1 Gene

genes like me logo Genes that share paralogs with CYSLTR1: view

Variants for CYSLTR1 Gene

Sequence variations from dbSNP and Humsavar for CYSLTR1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs167674 -- 78,280,499(-) tatat(G/T)aggta intron-variant
rs184410 -- 78,319,867(-) tcatc(A/G)tcact intron-variant
rs186494 -- 78,275,556(-) atgtt(C/T)ccctt intron-variant
rs224316 -- 78,321,613(-) tcccg(A/G)gttca intron-variant
rs320987 -- 78,279,828(-) ttttc(G/T)tagga intron-variant

Relevant External Links for CYSLTR1 Gene

HapMap Linkage Disequilibrium report
CYSLTR1
Human Gene Mutation Database (HGMD)
CYSLTR1
Locus Specific Mutation Databases (LSDB)
CYSLTR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CYSLTR1 Gene

Disorders for CYSLTR1 Gene

(1) University of Copenhagen DISEASES for CYSLTR1 Gene

(22) Novoseek inferred disease relationships for CYSLTR1 Gene

Disease -log(P) Hits PubMed IDs
asthma 77.3 53
asthma exercise-induced 55.1 1
monocytic leukemia 48.9 1
nasal polyps 47.9 2
churg-strauss syndrome 46.5 3

Relevant External Links for CYSLTR1

Genetic Association Database (GAD)
CYSLTR1
Human Genome Epidemiology (HuGE) Navigator
CYSLTR1
genes like me logo Genes that share disorders with CYSLTR1: view

No data available for UniProtKB/Swiss-Prot for CYSLTR1 Gene

Publications for CYSLTR1 Gene

  1. Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PMID: 10391245) Lynch K.R. … Evans J.F. (Nature 1999) 2 3 4 23
  2. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PMID: 10462554) Sarau H.M. … Hay D.W.P. (Mol. Pharmacol. 1999) 2 3 4 23
  3. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PMID: 14749922) Choi J.H. … Shin H.D. (Hum. Genet. 2004) 3 23 49
  4. Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. (PMID: 16630147) Kim S.H. … Park H.S. (Clin. Exp. Allergy 2006) 3 23 49
  5. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PMID: 16771777) Zhang J. … Noguchi E. (Pediatr Allergy Immunol 2006) 3 23 49

Products for CYSLTR1 Gene

Sources for CYSLTR1 Gene

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