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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYSLTR1 Gene

protein-coding   GIFtS: 64
GCID: GC0XM077526

Cysteinyl Leukotriene Receptor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteinyl Leukotriene Receptor 11 2     LTD4 Receptor2 3
CYSLT12 3 5     CYSLT1R2
Cysteinyl Leukotriene D4 Receptor2 3     CYSLTR2
HMTMF812 3     CysLTR13
G-Protein Coupled Receptor HG552 3     

External Ids:    HGNC: 174511   Entrez Gene: 108002   Ensembl: ENSG000001731987   OMIM: 3002015   UniProtKB: Q9Y2713   

Export aliases for CYSLTR1 gene to outside databases

Previous GC identifers: GC0XM073074 GC0XM074489 GC0XM075569 GC0XM076284 GC0XM077334 GC0XM071107


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYSLTR1 Gene:
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for
cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a
phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction
and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the
lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for CYSLTR1 Gene: 
CYSLTR1 (cysteinyl leukotriene receptor 1) is a protein-coding gene. Diseases associated with CYSLTR1 include churg-strauss syndrome, and brain injury, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include leukotriene receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271
Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without
asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil
migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4
>> LTE4 = LTC4 >> LTB4

summary for CYSLTR1 Gene:
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4,
LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase
enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene
receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high
affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are
expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting
that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of
vascular, respiratory and gastrointestinal smooth muscle.

Gene Wiki entry for CYSLTR1 (Cysteinyl leukotriene receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYSLTR1 gene promoter:
         E2F-4   E2F-3a   E2F-5   FOXF2   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYSLTR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYSLTR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYSLTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2-q21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq13-q21

CYSLTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYSLTR1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM077526:  view genomic region     (about GC identifiers)

Start:
77,526,961 bp from pter      End:
77,583,087 bp from pter
Size:
56,127 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271 (See protein sequence)
Recommended Name: Cysteinyl leukotriene receptor 1  
Size: 337 amino acids; 38541 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast
(Onon), are used in the treatment of the asthma crisis
Secondary accessions: B2R954 D3DTE4 Q5JS94 Q8IV19

Explore the universe of human proteins at neXtProt for CYSLTR1: NX_Q9Y271

Explore proteomics data for CYSLTR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y271

  • CYSLTR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYSLTR1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269115.1  NP_001269116.1  NP_001269117.1  NP_006630.1  

    ENSEMBL proteins: 
     ENSP00000362401  
    Reactome Protein details: Q9Y271
    Human Recombinant Protein Products for CYSLTR1: 
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    Cloud-Clone Corp. Proteins for CYSLTR1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane TAS10391245
    GO:0016021integral to membrane ----

    CYSLTR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LTNR: GPCR / Class A : Leukotriene receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CysLT1 receptor 
    Leukotriene receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013310 CLT1_recept
     IPR004071 Cyst_leuk_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y271

    ProtoNet protein and cluster: Q9Y271

    1 Blocks protein domain: IPB004071 Cysteinyl leukotriene receptor family signature

    UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CYSLTR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLTR1_HUMAN, Q9Y271
    Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without
    asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil
    migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a
    phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4
    >> LTE4 = LTC4 >> LTB4

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004974leukotriene receptor activity IEA--
         
    CYSLTR1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cysltr1):
     cardiovascular system  cellular  immune system  respiratory system 

    CYSLTR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cysltr1tm1Ykn for CYSLTR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYSLTR1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYSLTR1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYSLTR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYSLTR1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Prostanoid ligand receptors
    Eicosanoid ligand-binding receptors0.60
    Leukotriene receptors0.33
    5Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CYSLTR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 GeneGo (Thomson Reuters) Pathway for CYSLTR1
        Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    2 BioSystems Pathways for CYSLTR1
        GPCRs, Class A Rhodopsin-like
    Endothelins

    5/9        Reactome Pathways for CYSLTR1 (see all 9)
        GPCR downstream signaling
    Eicosanoid ligand-binding receptors
    Leukotriene receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR

    1 PharmGKB Pathway for CYSLTR1
        Leukotriene modifiers pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for CYSLTR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    CYSLTR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYSLTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for CYSLTR1 (ENSP000003624014) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AVPR1BENSP000003560944STRING: ENSP00000356094
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CCKARENSP000002955894STRING: ENSP00000295589
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IEA--
    GO:0006935chemotaxis IEA--
    GO:0006952defense response TAS10391245
    GO:0006954inflammatory response IEA--
    GO:0007166cell surface receptor signaling pathway ----

    CYSLTR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYSLTR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CYSLTR1

    Compounds for CYSLTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-ODYALTB-omega-Hydroxylase inhibitor[34450-18-5]
    MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]
    Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active [128312-51-6]
    LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
    Leukotriene B4BLT1/BLT2 receptor agonist and potent chemotactic factor[71160-24-2]

    2 HMDB Compounds for CYSLTR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Leukotriene D4LTD (see all 4)73836-78-9--

    5 DrugBank Compounds for CYSLTR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Montelukast-- 158966-92-8targetantagonist15456537 17199874 16815057 16815146 15013935 11752352
    Pranlukast-- 103177-37-3targetantagonist17112405 11264758 11854273 15475658 11752352 16864492
    Zafirlukast-- 107753-78-6targetantagonist11006272 11061985 9042024 10851239 11752352 11979731
    Nedocromil-- 69049-73-6targetsuppressor16164449 17139284 20558817 8386571 17016423
    Cinalukast-- 128312-51-6targetantagonist9042047 11752352 19826192

    10/17 IUPHAR Ligands for CYSLTR1 (CysLT1 receptor) (see all 17)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]LTD4
    AgonistFull agonist8.6 - 10.69547367 9504401
    [3H]ICI-198615
    AntagonistAntagonist10.61329767
    LTD4
    AgonistFull agonist9.410391245
    zafirlukast
    AntagonistAntagonist8.911996896 9504401
    pranlukast
    AntagonistAntagonist7.1 - 8.811996896 9504401
    SR2640
    AntagonistAntagonist8.7--
    ICI198615
    AntagonistAntagonist8.4 - 8.6--
    montelukast
    AntagonistAntagonist8.5511996896
    sulukast
    AntagonistAntagonist8.3--
    verlukast
    AntagonistAntagonist810391245

    10/33 Novoseek inferred chemical compound relationships for CYSLTR1 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltd4 95.7 137 1645886 (4), 1313876 (3), 9118902 (3), 1323587 (3) (see all 68)
    pranlukast 92.8 32 8887574 (2), 11527250 (2), 17443897 (2), 15650315 (2) (see all 19)
    montelukast 92.8 54 18332235 (3), 17883728 (3), 18566548 (2), 18946234 (2) (see all 32)
    pobilukast 88.4 2 10462554 (1), 8298810 (1)
    zafirlukast 85.9 7 9042024 (1), 10462554 (1), 11888331 (1), 12735786 (1) (see all 6)
    ym-158 84.7 3 10887942 (1)
    ltc4 83.2 17 1678589 (2), 9042024 (1), 7842366 (1), 17397245 (1) (see all 10)
    ly171883 82.8 3 8298810 (1), 2175680 (1)
    mk 571 79.3 6 11438743 (1), 1611229 (1), 18028998 (1), 13679572 (1) (see all 5)
    lte4 76.2 4 16304255 (1), 16776674 (1), 1323587 (1)

    Search CenterWatch for drugs/clinical trials and news about CYSLTR1 / CLTR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CYSLTR1 gene (4 alternative transcripts): 
    NM_001282186.1  NM_001282187.1  NM_001282188.1  NM_006639.3  

    Unigene Cluster for CYSLTR1:

    Cysteinyl leukotriene receptor 1
    Hs.733809  [show with all ESTs]
    Unigene Representative Sequence: NM_006639
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373304(uc004edb.3 uc010nma.3 uc010nmb.3) ENST00000493254

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    Additional mRNA sequence: 

    AF119711.1 AF133266.1 AK313643.1 BC035750.1 DQ131799.1 DQ131800.1 DQ131801.1 DQ131802.1 
    DQ131803.1 

    2 DOTS entries:

    DT.105970  DT.121289365 

    24/35 AceView cDNA sequences (see all 35):

    BM920299 BX106054 NM_006639 AA737451 AF119711 AF133266 BQ880456 CK903387 
    AA906003 AI215416 AI948890 BC035750 BE504249 AU141814 BE549540 BV192244 
    CF147786 CD701219 AA865828 AA831526 CK903386 AA761471 BM955973 AK023929 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYSLTR1 expression in normal human tissues (normalized intensities)      CYSLTR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATGTTTA
    CYSLTR1 Expression
    About this image


    CYSLTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             bone marrow-derived macrophages   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Choroid Plexus (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus

    See CYSLTR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYSLTR1

    SOURCE GeneReport for Unigene cluster: Hs.733809

    UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271
    Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower
    expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta,
    small intestine, pancreas, colon and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYSLTR1: 
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              Allergy & Asthma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYSLTR1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cysltr11 , 5 cysteinyl leukotriene receptor 11, 5 87.56(n)1
    88.06(a)1
      X (47.36 cM)5
    588611  NM_021476.41  NP_067451.21 
     1065743465 
    chicken
    (Gallus gallus)
    Aves CYSLTR11 cysteinyl leukotriene receptor 1 66.36(n)
    68.83(a)
      428691  XM_426249.3  XP_426249.2 
    lizard
    (Anolis carolinensis)
    Reptilia CYSLTR16
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343202.1(2185221-2187114)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.260642 Transcribed sequence with moderate similarity to protein more 73.37(n)    CD604109.1 


    ENSEMBL Gene Tree for CYSLTR1 (if available)
    TreeFam Gene Tree for CYSLTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYSLTR1 gene
    P2RY42  LPAR42  CYSLTR22  P2RY22  PTAFR2  OXGR12  P2RY112  P2RY12  
    GPR172  P2RY62  GPR1742  LPAR62  LPAR52  GPR1832  P2RY102  SUCNR12  
    18/39 SIMAP similar genes for CYSLTR1 using alignment to 1 protein entry:     CLTR1_HUMAN(see all similar genes):
    CYSLTR2    KPG_011    LPAR6    P2RY5    GPR17    CX3CR1
    GPR183    P2RY1    CMKLR1    PTAFR    CCR6    GPR34
    SUCNR1    XCR1    gpcr    GPR174    LPAR4    OPRK1

    CYSLTR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/803 SNPs in CYSLTR1 are shown (see all 803)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865756541,2
    --77499469(+) TTATCA/GTTTGT 1 -- ds50010--------
    rs1499958011,2
    C--77499814(+) CTCCTC/TTTTCT 2 K R mis10--------
    rs1457133971,2
    C,F--77499830(+) AGAGGC/TCTTCT 2 T A mis11Minor allele frequency- T:0.00NA 4234
    rs3209951,2
    C,F,A,H--77499876(-) ACATTA/C/TAGAAA 3 L F mis1 syn123MN NS EA NA WA CSA 6905
    rs1429932071,2
    C,F--77499894(+) CTTTTC/TCTAAA 2 R syn11Minor allele frequency- T:0.00NA 4430
    rs1997253271,2
    --77499895(+) TTTTCC/GTAAAG 2 T R mis10--------
    rs1914259881,2
    C--77499974(+) GACCAA/C/TGGACT 3 M V L mis10--------
    rs2013015391,2
    C--77499981(+) GACTTC/TTGCAT 2 Q syn10--------
    rs1487328521,2
    C--77500069(+) TGAAAC/GTGACT 2 T S mis11Minor allele frequency- G:0.00NA 4532
    rs1389812901,2
    C--77500113(+) ATAGCC/TTTTTT 2 K syn11Minor allele frequency- T:0.00NA 4488

    HapMap Linkage Disequilibrium report for CYSLTR1 (77526961 - 77583087 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CYSLTR1: --

    Human Gene Mutation Database (HGMD): CYSLTR1

    Locus Specific Mutation Databases (LSDB): CYSLTR1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300201    OMIM disorders: --

    20/40 diseases for CYSLTR1 (see all 40):    About MalaCards
    churg-strauss syndrome    brain injury    pulmonary eosinophilia    eosinophilia
    asthma    atopy    mediastinitis    traumatic brain injury
    monocytic leukemia    sinusitis    rhinitis    sleep apnea
    angioedema    sleep disorder    urticaria    pulmonary fibrosis
    allergic rhinitis    tonsillitis    vasculitis    atopic dermatitis

    1 disease from the University of Copenhagen DISEASES database for CYSLTR1:
    Asthma

    CYSLTR1 for disorders           About GeneDecksing

    10/22 Novoseek inferred disease relationships for CYSLTR1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 77.3 78 20003473 (4), 16771777 (4), 16304255 (3), 16776674 (3) (see all 36)
    asthma exercise-induced 55.1 1 17883728 (1)
    monocytic leukemia 48.9 1 9478929 (1)
    nasal polyps 47.9 3 16739673 (1), 16689996 (1)
    churg-strauss syndrome 46.5 3 10335014 (2), 12735786 (1)
    inflammation 41.1 9 18048362 (1), 17693579 (1), 15650315 (1), 18606091 (1) (see all 8)
    eosinophilia 31 2 8887574 (2)
    ischemic brain injury 29 4 16756959 (1), 16650938 (1)
    sinusitis 26.9 1 20126572 (1)
    rhinitis 26 6 16771777 (4), 1964905 (1)

    Genetic Association Database (GAD): CYSLTR1
    Human Genome Epidemiology (HuGE) Navigator: CYSLTR1 (31 documents)

    Export disorders for CYSLTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYSLTR1 gene, integrated from 9 sources (see all 259):
    (articles sorted by number of sources associating them with CYSLTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PubMed id 10391245)1, 2, 3, 9 Lynch K.R.... Evans J.F. (1999)
    2. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PubMed id 10462554)1, 2, 3, 9 Sarau H.M....Hay D.W. (1999)
    3. Variable expression of cysteinyl leukotriene type I r eceptor splice variants in asthmatic females with different promoter haplotypes . (PubMed id 20003473)1, 4, 9 Sokolowska M....Pawliczak R. (2009)
    4. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PubMed id 16771777)1, 4, 9 Zhang J....Noguchi E. (2006)
    5. Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. (PubMed id 16630147)1, 4, 9 Kim S.H....Park H.S. (2006)
    6. Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity. (PubMed id 17641958)1, 4, 9 Kim S.H....Park H.S. (2007)
    7. The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma. (PubMed id 16776674)1, 4, 9 Hao L....Holloway J.W. (2006)
    8. 927T>C polymorphism of the cysteinyl-leukotriene type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis. (PubMed id 16846449)1, 4, 9 Arriba-Mendez S....Lorente F. (2006)
    9. A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate. (PubMed id 17558309)1, 4, 9 Thompson M.D....Siminovitch K.A. (2007)
    10. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. (PubMed id 17924829)1, 4, 9 Kim S.H....Park H.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10800 HGNC: 17451 AceView: CYSLTR1 Ensembl:ENSG00000173198 euGenes: HUgn10800
    ECgene: CYSLTR1 Kegg: 10800 H-InvDB: CYSLTR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYSLTR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYSLTR1 gene:
    Search GeneIP for patents involving CYSLTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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