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CYSLTR1 Gene

protein-coding   GIFtS: 62
GCID: GC0XM077526

Cysteinyl Leukotriene Receptor 1

  See CYSLTR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteinyl Leukotriene Receptor 11 2     LTD4 Receptor2 3
CYSLT12 3 5     CYSLT1R2
Cysteinyl Leukotriene D4 Receptor2 3     CYSLTR2
HMTMF812 3     CysLTR13
G-Protein Coupled Receptor HG552 3     

External Ids:    HGNC: 174511   Entrez Gene: 108002   Ensembl: ENSG000001731987   OMIM: 3002015   UniProtKB: Q9Y2713   

Export aliases for CYSLTR1 gene to outside databases

Previous GC identifers: GC0XM073074 GC0XM074489 GC0XM075569 GC0XM076284 GC0XM077334 GC0XM071107


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYSLTR1 Gene:
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for
cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a
phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction
and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the
lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for CYSLTR1 Gene:
CYSLTR1 (cysteinyl leukotriene receptor 1) is a protein-coding gene. Diseases associated with CYSLTR1 include churg-strauss syndrome, and brain injury. GO annotations related to this gene include leukotriene receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271
Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without
asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil
migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4
>> LTE4 = LTC4 >> LTB4

summary for CYSLTR1 Gene:
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4,
LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase
enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene
receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high
affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are
expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting
that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of
vascular, respiratory and gastrointestinal smooth muscle.

Gene Wiki entry for CYSLTR1 (Cysteinyl leukotriene receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CYSLTR1 gene promoter:
         E2F-4   E2F-3a   E2F-5   FOXF2   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYSLTR1 promoter sequence
   Search Chromatin IP Primers for CYSLTR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYSLTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2-q21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq13-q21

CYSLTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYSLTR1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM077526:  view genomic region     (about GC identifiers)

Start:
77,526,961 bp from pter      End:
77,583,087 bp from pter
Size:
56,127 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271 (See protein sequence)
Recommended Name: Cysteinyl leukotriene receptor 1  
Size: 337 amino acids; 38541 Da
Miscellaneous: Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast
(Onon), are used in the treatment of the asthma crisis
Secondary accessions: B2R954 D3DTE4 Q5JS94 Q8IV19

Explore the universe of human proteins at neXtProt for CYSLTR1: NX_Q9Y271

Explore proteomics data for CYSLTR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6, Asn169, Asn180, Asn262
  • Modification sites at PhosphoSitePlus

  • See CYSLTR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269115.1  NP_001269116.1  NP_001269117.1  NP_006630.1  

    ENSEMBL proteins: 
     ENSP00000362401  
    Reactome Protein details: Q9Y271

    CYSLTR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CYSLTR1
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CYSLTR1

     
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    Search eBioscience for ELISAs for CYSLTR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LTNR: GPCR / Class A : Leukotriene receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CysLT1 receptor
    Leukotriene receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013310 CLT1_recept
     IPR004071 Cyst_leuk_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y271

    ProtoNet protein and cluster: Q9Y271

    1 Blocks protein domain: IPB004071 Cysteinyl leukotriene receptor family signature

    UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CYSLTR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLTR1_HUMAN, Q9Y271
    Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without
    asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil
    migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a
    phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4
    >> LTE4 = LTC4 >> LTB4

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004974leukotriene receptor activity IEA--
         
    Find genes that share ontologies with CYSLTR1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cysltr1):
     cardiovascular system  cellular  immune system  respiratory system 

    Find genes that share phenotypes with CYSLTR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cysltr1tm1Ykn for CYSLTR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYSLTR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYSLTR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYSLTR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYSLTR1

    miRNA
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    miRTarBase miRNAs that target CYSLTR1:
    hsa-mir-335-5p (MIRT017591)

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    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CYSLTR1 (NM_006639)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYSLTR1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYSLTR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLTR1_HUMAN, Q9Y271: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane TAS10391245
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CYSLTR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYSLTR1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Leukotriene receptors0.00
    5Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with CYSLTR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYSLTR1
        Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    2 BioSystems Pathways for CYSLTR1
        GPCRs, Class A Rhodopsin-like
    Endothelins

    2 Reactome Pathways for CYSLTR1
        Leukotriene receptors
    G alpha (q) signalling events

    1 PharmGKB Pathway for CYSLTR1
        Leukotriene modifiers pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for CYSLTR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYSLTR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYSLTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYSLTR1 (ENSP000003624014) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AVPR1BENSP000003560944STRING: ENSP00000356094
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CCKARENSP000002955894STRING: ENSP00000295589
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IEA--
    GO:0006935chemotaxis IEA--
    GO:0006952defense response TAS10391245
    GO:0006954inflammatory response IEA--
    GO:0007166cell surface receptor signaling pathway ----

    Find genes that share ontologies with CYSLTR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CYSLTR1
      Browse compounds at ApexBio 

    Compounds for CYSLTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-ODYALTB-omega-Hydroxylase inhibitor[34450-18-5]
    MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]
    Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active [128312-51-6]
    LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
    Leukotriene B4BLT1/BLT2 receptor agonist and potent chemotactic factor[71160-24-2]

    2 HMDB Compounds for CYSLTR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Leukotriene D4LTD (see all 4)73836-78-9--

    5 DrugBank Compounds for CYSLTR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Montelukast-- 158966-92-8targetantagonist15456537 17199874 16815057 16815146 15013935 11752352
    Pranlukast-- 103177-37-3targetantagonist17112405 11264758 11854273 15475658 11752352 16864492
    Zafirlukast-- 107753-78-6targetantagonist11006272 11061985 9042024 10851239 11752352 11979731
    Nedocromil-- 69049-73-6targetsuppressor16164449 17139284 20558817 8386571 17016423
    Cinalukast-- 128312-51-6targetantagonist9042047 11752352 19826192

    Selected IUPHAR Ligands for CYSLTR1 (CysLT1 receptor) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]LTD4
    AgonistFull agonist8.6 - 10.69547367 9504401
    [3H]ICI-198615
    AntagonistAntagonist10.61329767
    LTD4
    AgonistFull agonist9.410391245
    zafirlukast
    AntagonistAntagonist8.911996896 9504401
    pranlukast
    AntagonistAntagonist7.1 - 8.811996896 9504401
    SR2640
    AntagonistAntagonist8.7--
    ICI198615
    AntagonistAntagonist8.4 - 8.6--
    montelukast
    AntagonistAntagonist8.5511996896
    sulukast
    AntagonistAntagonist8.3--
    verlukast
    AntagonistAntagonist810391245

    Selected Novoseek inferred chemical compound relationships for CYSLTR1 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltd4 95.7 137 1645886 (4), 1313876 (3), 9118902 (3), 1323587 (3) (see all 68)
    pranlukast 92.8 32 8887574 (2), 11527250 (2), 17443897 (2), 15650315 (2) (see all 19)
    montelukast 92.8 54 18332235 (3), 17883728 (3), 18566548 (2), 18946234 (2) (see all 32)
    pobilukast 88.4 2 10462554 (1), 8298810 (1)
    zafirlukast 85.9 7 9042024 (1), 10462554 (1), 11888331 (1), 12735786 (1) (see all 6)
    ym-158 84.7 3 10887942 (1)
    ltc4 83.2 17 1678589 (2), 9042024 (1), 7842366 (1), 17397245 (1) (see all 10)
    ly171883 82.8 3 8298810 (1), 2175680 (1)
    mk 571 79.3 6 11438743 (1), 1611229 (1), 18028998 (1), 13679572 (1) (see all 5)
    lte4 76.2 4 16304255 (1), 16776674 (1), 1323587 (1)



    Find genes that share compounds with CYSLTR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYSLTR1 gene (4 alternative transcripts): 
    NM_001282186.1  NM_001282187.1  NM_001282188.1  NM_006639.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373304(uc004edb.3 uc010nma.3 uc010nmb.3) ENST00000493254

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    GenScript: all cDNA clones in your preferred vector: CYSLTR1 (NM_006639)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYSLTR1
      QuantiTect SYBR Green Assays in human, mouse, rat CYSLTR1
      QuantiFast Probe-based Assays in human, mouse, rat CYSLTR1

    Selected AceView cDNA sequences (see all 35):

    AA737451 AF133266 BX106054 CK903387 BQ880456 AF119711 NM_006639 BM920299 
    AA906003 BC035750 AI948890 BM955973 BE549540 BV192244 AA761471 AI215416 
    AA865828 AA831526 CK903386 CF147786 CD701219 AU141814 BE504249 AK023929 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYSLTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATGTTTA
    CYSLTR1 Expression
    About this image


    CYSLTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast-like cells
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CYSLTR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYSLTR1 Protein Expression

    UniProtKB/Swiss-Prot: CLTR1_HUMAN, Q9Y271
    Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower
    expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta,
    small intestine, pancreas, colon and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYSLTR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYSLTR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cysltr11 , 5 cysteinyl leukotriene receptor 11, 5 87.56(n)1
    88.06(a)1
      X (47.36 cM)5
    588611  NM_001281859.11  NP_001268788.11 
     1065743465 
    chicken
    (Gallus gallus)
    Aves CYSLTR11 cysteinyl leukotriene receptor 1 66.36(n)
    68.83(a)
      428691  XM_426249.4  XP_426249.3 
    lizard
    (Anolis carolinensis)
    Reptilia CYSLTR16
    cysteinyl leukotriene receptor 1
    56(a)
    1 ↔ 1
    GL343202.1(2185221-2187114)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cysltr11 cysteinyl leukotriene receptor 1 65.72(n)
    65.82(a)
      100497435  XM_004916899.1  XP_004916956.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.260642 Transcribed sequence with moderate similarity to protein more 73.37(n)    CD604109.1 


    ENSEMBL Gene Tree for CYSLTR1 (if available)
    TreeFam Gene Tree for CYSLTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYSLTR1 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for CYSLTR1 using alignment to 1 protein entry:     CLTR1_HUMAN(see all similar genes):
    CYSLTR2    KPG_011    LPAR6    GPR17    CX3CR1    GPR183
    P2RY1    CMKLR1    PTAFR    CCR6    GPR34    SUCNR1
    XCR1    gpcr    GPR174    LPAR4    OPRK1    P2RY8

    Find genes that share paralogs with CYSLTR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYSLTR1 (see all 803)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865756541,2
    --77499469(+) TTATCA/GTTTGT 1 -- ds50010--------
    rs1499958011,2
    C--77499814(+) CTCCTC/TTTTCT 2 K R mis10--------
    rs1457133971,2
    C,F--77499830(+) AGAGGC/TCTTCT 2 T A mis11Minor allele frequency- T:0.00NA 4234
    rs3209951,2
    C,F,A,H--77499876(-) ACATTA/C/TAGAAA 3 L F mis1 syn123MN NS EA NA WA CSA 6905
    rs1429932071,2
    C,F--77499894(+) CTTTTC/TCTAAA 2 R syn11Minor allele frequency- T:0.00NA 4430
    rs1997253271,2
    --77499895(+) TTTTCC/GTAAAG 2 T R mis10--------
    rs1914259881,2
    C--77499974(+) GACCAA/C/TGGACT 3 M V L mis10--------
    rs2013015391,2
    C--77499981(+) GACTTC/TTGCAT 2 Q syn10--------
    rs1487328521,2
    C--77500069(+) TGAAAC/GTGACT 2 T S mis11Minor allele frequency- G:0.00NA 4532
    rs1389812901,2
    C--77500113(+) ATAGCC/TTTTTT 2 K syn11Minor allele frequency- T:0.00NA 4488

    HapMap Linkage Disequilibrium report for CYSLTR1 (77526961 - 77583087 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CYSLTR1: --
    Human Gene Mutation Database (HGMD): CYSLTR1
    Locus Specific Mutation Databases (LSDB): CYSLTR1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300201    OMIM disorders: --

    4 diseases for CYSLTR1:    
    About MalaCards
    churg-strauss syndrome    brain injury    atopy    asthma

    1 disease from the University of Copenhagen DISEASES database for CYSLTR1:
    Asthma

    Find genes that share disorders with CYSLTR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYSLTR1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 77.3 78 20003473 (4), 16771777 (4), 16304255 (3), 16776674 (3) (see all 36)
    asthma exercise-induced 55.1 1 17883728 (1)
    monocytic leukemia 48.9 1 9478929 (1)
    nasal polyps 47.9 3 16739673 (1), 16689996 (1)
    churg-strauss syndrome 46.5 3 10335014 (2), 12735786 (1)
    inflammation 41.1 9 18048362 (1), 17693579 (1), 15650315 (1), 18606091 (1) (see all 8)
    eosinophilia 31 2 8887574 (2)
    ischemic brain injury 29 4 16756959 (1), 16650938 (1)
    sinusitis 26.9 1 20126572 (1)
    rhinitis 26 6 16771777 (4), 1964905 (1)

    Genetic Association Database (GAD): CYSLTR1
    Human Genome Epidemiology (HuGE) Navigator: CYSLTR1 (31 documents)

    Export disorders for CYSLTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYSLTR1 gene, integrated from 10 sources (see all 261):
    (articles sorted by number of sources associating them with CYSLTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PubMed id 10391245)1, 2, 3, 9 Lynch K.R.... Evans J.F. (Nature 1999)
    2. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PubMed id 10462554)1, 2, 3, 9 Sarau H.M.... Hay D.W.P. (Mol. Pharmacol. 1999)
    3. Variable expression of cysteinyl leukotriene type I receptor splice variants in asthmatic females with different promoter haplotypes. (PubMed id 20003473)1, 4, 9 Sokolowska M....Pawliczak R. (BMC Immunol. 2009)
    4. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PubMed id 16771777)1, 4, 9 Zhang J....Noguchi E. (Pediatr Allergy Immunol 2006)
    5. Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. (PubMed id 16630147)1, 4, 9 Kim S.H....Park H.S. (Clin. Exp. Allergy 2006)
    6. Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity. (PubMed id 17641958)1, 4, 9 Kim S.H....Park H.S. (J. Clin. Immunol. 2007)
    7. The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma. (PubMed id 16776674)1, 4, 9 Hao L....Holloway J.W. (Clin. Exp. Allergy 2006)
    8. 927T&gt;C polymorphism of the cysteinyl-leukotriene type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis. (PubMed id 16846449)1, 4, 9 Arriba-Mendez S....Lorente F. (Pediatr Allergy Immunol 2006)
    9. A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate. (PubMed id 17558309)1, 4, 9 Thompson M.D....Siminovitch K.A. (Pharmacogenet. Genomics 2007)
    10. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. (PubMed id 17924829)1, 4, 9 Kim S.H....Park H.S. (Pharmacogenomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10800 HGNC: 17451 AceView: CYSLTR1 Ensembl:ENSG00000173198 euGenes: HUgn10800
    ECgene: CYSLTR1 Kegg: 10800 H-InvDB: CYSLTR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYSLTR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYSLTR1 gene:
    Search GeneIP for patents involving CYSLTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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