Aliases for CYSLTR1 Gene
External Ids for CYSLTR1 Gene
Previous GeneCards Identifiers for CYSLTR1 Gene
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for CYSLTR1 Gene
CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include churg-strauss syndrome and brain injury. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include leukotriene receptor activity. An important paralog of this gene is PTAFR.
UniProtKB/Swiss-Prot for CYSLTR1 Gene
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. CysLT1 and CysLT2 receptors are expressed most abundantly on myeloid cells. CysLT2 has a suppressive effect on CysLT1 expression, suggesting that it has an autoregulatory role on CysLT1 levels. The main role of CysLT receptors is contraction of vascular, respiratory and gastrointestinal smooth muscle.