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Aliases for CYR61 Gene

Aliases for CYR61 Gene

  • Cysteine-Rich, Angiogenic Inducer, 61 2 3
  • IGFBP10 3 4 6
  • Insulin-Like Growth Factor-Binding Protein 10 3 4
  • IGF-Binding Protein 10 3 4
  • CCN Family Member 1 3 4
  • IGFBP-10 3 4
  • IBP-10 3 4
  • GIG1 3 4
  • CCN1 3 4
  • Cysteine-Rich Heparin-Binding Protein 61 3
  • Cysteine-Rich, Anigogenic Inducer, 61 3
  • Cysteine-Rich Angiogenic Inducer 61 4
  • Protein CYR61 3
  • Protein GIG1 4

External Ids for CYR61 Gene

Previous Symbols for CYR61 Gene

  • IGFBP10

Summaries for CYR61 Gene

Entrez Gene Summary for CYR61 Gene

  • The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

GeneCards Summary for CYR61 Gene

CYR61 (Cysteine-Rich, Angiogenic Inducer, 61) is a Protein Coding gene. Diseases associated with CYR61 include epispadias and breast cancer. Among its related pathways are Angiogenesis (CST) and amb2 Integrin signaling. GO annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for CYR61 Gene

  • Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Wiki entry for CYR61 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYR61 Gene

Genomics for CYR61 Gene

Genomic Location for CYR61 Gene

Start:
85,580,761 bp from pter
End:
85,583,967 bp from pter
Size:
3,207 bases
Orientation:
Plus strand

Genomic View for CYR61 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYR61 Gene

Regulatory Elements for CYR61 Gene

Proteins for CYR61 Gene

  • Protein details for CYR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00622-CYR61_HUMAN
    Recommended name:
    Protein CYR61
    Protein Accession:
    O00622
    Secondary Accessions:
    • O14934
    • O43775
    • Q9BZL7

    Protein attributes for CYR61 Gene

    Size:
    381 amino acids
    Molecular mass:
    42027 Da
    Quaternary structure:
    • Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5

neXtProt entry for CYR61 Gene

Proteomics data for CYR61 Gene at MOPED

Post-translational modifications for CYR61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYR61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYR61 Gene

Domains for CYR61 Gene

UniProtKB/Swiss-Prot:

CYR61_HUMAN
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.:
    • O00622
  • Contains 1 IGFBP N-terminal domain.:
    • O00622
  • Contains 1 TSP type-1 domain.:
    • O00622
  • Contains 1 VWFC domain.:
    • O00622
Family:
  • Belongs to the CCN family.:
    • O00622
genes like me logo Genes that share domains with CYR61: view

No data available for Gene Families for CYR61 Gene

Function for CYR61 Gene

Molecular function for CYR61 Gene

GENATLAS Biochemistry: cysteine-rich angiogenic 61,related protein 4,immediate early gene,low affinity,expressed in embryonic tissues and in tumor cell lines derived from the nervous system,putatively involved in the control of cell proliferation,promoting angiogenesis and chondrogenesis during mouse development (see TSG1E)
UniProtKB/Swiss-Prot Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Ontology (GO) - Molecular Function for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with CYR61: view
genes like me logo Genes that share phenotypes with CYR61: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYR61 Gene

Localization for CYR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYR61 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYR61 Gene COMPARTMENTS Subcellular localization image for CYR61 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0031012 extracellular matrix IDA 23658023
genes like me logo Genes that share ontologies with CYR61: view

Pathways for CYR61 Gene

genes like me logo Genes that share pathways with CYR61: view

Pathways by source for CYR61 Gene

Gene Ontology (GO) - Biological Process for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20675382
GO:0002041 intussusceptive angiogenesis IEA --
GO:0003181 atrioventricular valve morphogenesis IEA --
genes like me logo Genes that share ontologies with CYR61: view

Compounds for CYR61 Gene

(18) Novoseek inferred chemical compound relationships for CYR61 Gene

Compound -log(P) Hits PubMed IDs
lm 609 59.8 2
matrigel 43 1
vegf 39.2 36
cysteine 38.3 8
estrogen 32 21
genes like me logo Genes that share compounds with CYR61: view

Transcripts for CYR61 Gene

mRNA/cDNA for CYR61 Gene

Unigene Clusters for CYR61 Gene

Cysteine-rich, angiogenic inducer, 61:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYR61 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for CYR61 Gene

GeneLoc Exon Structure for
CYR61
ECgene alternative splicing isoforms for
CYR61

Expression for CYR61 Gene

mRNA expression in normal human tissues for CYR61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYR61 Gene

This gene is overexpressed in Artery - Aorta (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYR61 Gene

SOURCE GeneReport for Unigene cluster for CYR61 Gene Hs.8867

genes like me logo Genes that share expressions with CYR61: view

Orthologs for CYR61 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYR61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYR61 36
  • 99.83 (n)
  • 99.74 (a)
CYR61 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYR61 36
  • 92.65 (n)
  • 93.18 (a)
CYR61 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYR61 36
  • 90.55 (n)
  • 94.23 (a)
CYR61 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyr61 36
  • 88.95 (n)
  • 92.84 (a)
Cyr61 16
Cyr61 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYR61 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYR61 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyr61 36
  • 88.77 (n)
  • 92.84 (a)
chicken
(Gallus gallus)
Aves CYR61 36
  • 78.14 (n)
  • 83.87 (a)
CYR61 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYR61 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64237 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cyr61 36
  • 71.56 (n)
  • 79.47 (a)
Str.9694 36
zebrafish
(Danio rerio)
Actinopterygii cyr61 37
  • 67 (a)
OneToOne
zgc:85866 36
  • 68.4 (n)
  • 68.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ccn 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
Species with no ortholog for CYR61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYR61 Gene

ENSEMBL:
Gene Tree for CYR61 (if available)
TreeFam:
Gene Tree for CYR61 (if available)

Paralogs for CYR61 Gene

Paralogs for CYR61 Gene

Selected SIMAP similar genes for CYR61 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYR61: view

Variants for CYR61 Gene

Sequence variations from dbSNP and Humsavar for CYR61 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1062805 -- 85,582,190(+) CTTGG(C/T)AAGGA reference, synonymous-codon
rs1139740 -- 85,581,969(+) GAATC(A/T)CACTC missense, reference
rs1139745 -- 85,582,278(+) AGCGG(A/C)TCCCT missense, reference
rs1139746 -- 85,582,440(+) CATCC(G/T)ATACA missense, reference
rs1804662 -- 85,582,441(+) ATCCT(A/G)TACAA reference, synonymous-codon

Relevant External Links for CYR61 Gene

HapMap Linkage Disequilibrium report
CYR61
Human Gene Mutation Database (HGMD)
CYR61

No data available for Structural Variations from Database of Genomic Variants (DGV) for CYR61 Gene

Disorders for CYR61 Gene

(1) University of Copenhagen DISEASES for CYR61 Gene

(43) Novoseek inferred disease relationships for CYR61 Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 68.7 15
neovascularization 57.2 5
tumors 40.2 74
rhabdomyosarcoma 34.9 1
breast cancer 34.5 48

Relevant External Links for CYR61

Genetic Association Database (GAD)
CYR61
Human Genome Epidemiology (HuGE) Navigator
CYR61
genes like me logo Genes that share disorders with CYR61: view

No data available for UniProtKB/Swiss-Prot for CYR61 Gene

Publications for CYR61 Gene

  1. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. (PMID: 9135077) Jay P. … Berta P. (Oncogene 1997) 2 3 4 23
  2. Adhesion of human umbilical vein endothelial cells to the immediate- early gene product Cyr61 is mediated through integrin alphavbeta3. (PMID: 9446626) Kireeva M.L. … Lau L.F. (J. Biol. Chem. 1998) 3 4 23
  3. Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system. (PMID: 9536281) Martinerie C. … Perbal B. (Mol. Pathol. 1997) 3 4 23
  4. Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. (PMID: 10821835) Chen N. … Lau L.F. (J. Biol. Chem. 2000) 3 4 23
  5. Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. (PMID: 10852911) Albrecht C. … Nitsch R.M. (J. Biol. Chem. 2000) 3 4 23

Products for CYR61 Gene

Sources for CYR61 Gene

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