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Aliases for CYR61 Gene

Aliases for CYR61 Gene

  • Cysteine Rich Angiogenic Inducer 61 2 3
  • Cysteine-Rich, Angiogenic Inducer, 61 2 3 5
  • Insulin-Like Growth Factor-Binding Protein 10 3 4
  • IGF-Binding Protein 10 3 4
  • CCN Family Member 1 3 4
  • IGFBP-10 3 4
  • IGFBP10 3 4
  • IBP-10 3 4
  • CCN1 3 4
  • GIG1 3 4
  • Cysteine-Rich Heparin-Binding Protein 61 3
  • Cysteine-Rich, Anigogenic Inducer, 61 3
  • Cysteine-Rich Angiogenic Inducer 61 4
  • Protein GIG1 4

External Ids for CYR61 Gene

Previous HGNC Symbols for CYR61 Gene

  • IGFBP10

Previous GeneCards Identifiers for CYR61 Gene

  • GC01P086445
  • GC01P085188
  • GC01P085334
  • GC01P085469
  • GC01P085758
  • GC01P086046
  • GC01P084157

Summaries for CYR61 Gene

Entrez Gene Summary for CYR61 Gene

  • The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

GeneCards Summary for CYR61 Gene

CYR61 (Cysteine Rich Angiogenic Inducer 61) is a Protein Coding gene. Diseases associated with CYR61 include Epispadias and Periapical Periodontitis. Among its related pathways are Hypertrophy Model and RhoA signaling pathway. GO annotations related to this gene include heparin binding and extracellular matrix binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for CYR61 Gene

  • Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Wiki entry for CYR61 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYR61 Gene

Genomics for CYR61 Gene

Regulatory Elements for CYR61 Gene

Enhancers for CYR61 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYR61 on UCSC Golden Path with GeneCards custom track

Promoters for CYR61 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYR61 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYR61 Gene

Chromosome:
1
Start:
85,580,761 bp from pter
End:
85,583,967 bp from pter
Size:
3,207 bases
Orientation:
Plus strand

Genomic View for CYR61 Gene

Genes around CYR61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYR61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYR61 Gene

Proteins for CYR61 Gene

  • Protein details for CYR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00622-CYR61_HUMAN
    Recommended name:
    Protein CYR61
    Protein Accession:
    O00622
    Secondary Accessions:
    • O14934
    • O43775
    • Q9BZL7

    Protein attributes for CYR61 Gene

    Size:
    381 amino acids
    Molecular mass:
    42027 Da
    Quaternary structure:
    • Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

    Three dimensional structures from OCA and Proteopedia for CYR61 Gene

neXtProt entry for CYR61 Gene

Proteomics data for CYR61 Gene at MOPED

Post-translational modifications for CYR61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYR61 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CYR61 (CYR61)

No data available for DME Specific Peptides for CYR61 Gene

Domains & Families for CYR61 Gene

Gene Families for CYR61 Gene

Graphical View of Domain Structure for InterPro Entry

O00622

UniProtKB/Swiss-Prot:

CYR61_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the CCN family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CYR61: view

Function for CYR61 Gene

Molecular function for CYR61 Gene

GENATLAS Biochemistry:
cysteine-rich angiogenic 61,related protein 4,immediate early gene,low affinity,expressed in embryonic tissues and in tumor cell lines derived from the nervous system,putatively involved in the control of cell proliferation,promoting angiogenesis and chondrogenesis during mouse development (see TSG1E)
UniProtKB/Swiss-Prot Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Ontology (GO) - Molecular Function for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA,IBA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with CYR61: view
genes like me logo Genes that share phenotypes with CYR61: view

Animal Models for CYR61 Gene

MGI Knock Outs for CYR61:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYR61 Gene

Localization for CYR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYR61 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYR61 Gene COMPARTMENTS Subcellular localization image for CYR61 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for CYR61 Gene

Pathways & Interactions for CYR61 Gene

genes like me logo Genes that share pathways with CYR61: view

Pathways by source for CYR61 Gene

Gene Ontology (GO) - Biological Process for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20675382
GO:0002041 intussusceptive angiogenesis IEA --
GO:0003181 atrioventricular valve morphogenesis IEA --
genes like me logo Genes that share ontologies with CYR61: view

No data available for SIGNOR curated interactions for CYR61 Gene

Drugs & Compounds for CYR61 Gene

(8) Drugs for CYR61 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for CYR61 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYR61: view

Transcripts for CYR61 Gene

mRNA/cDNA for CYR61 Gene

Unigene Clusters for CYR61 Gene

Cysteine-rich, angiogenic inducer, 61:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYR61 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for CYR61 Gene

GeneLoc Exon Structure for
CYR61
ECgene alternative splicing isoforms for
CYR61

Expression for CYR61 Gene

mRNA expression in normal human tissues for CYR61 Gene

mRNA differential expression in normal tissues according to GTEx for CYR61 Gene

This gene is overexpressed in Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for CYR61 Gene

This gene is overexpressed in Ovary (34.0), Breast (12.6), Amniocyte (10.7), and Bone marrow mesenchymal stem cell (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYR61 Gene



SOURCE GeneReport for Unigene cluster for CYR61 Gene Hs.8867

genes like me logo Genes that share expression patterns with CYR61: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYR61 Gene

Orthologs for CYR61 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYR61 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYR61 35
  • 92.65 (n)
  • 93.18 (a)
CYR61 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYR61 35
  • 90.55 (n)
  • 94.23 (a)
CYR61 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyr61 35
  • 88.95 (n)
  • 92.84 (a)
Cyr61 16
Cyr61 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYR61 35
  • 99.83 (n)
  • 99.74 (a)
CYR61 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyr61 35
  • 88.77 (n)
  • 92.84 (a)
oppossum
(Monodelphis domestica)
Mammalia CYR61 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYR61 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYR61 35
  • 78.14 (n)
  • 83.87 (a)
CYR61 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYR61 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyr61 35
  • 71.56 (n)
  • 79.47 (a)
Str.9694 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64237 35
zebrafish
(Danio rerio)
Actinopterygii zgc:85866 35
  • 68.4 (n)
  • 68.77 (a)
cyr61 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ccn 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
Species with no ortholog for CYR61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYR61 Gene

ENSEMBL:
Gene Tree for CYR61 (if available)
TreeFam:
Gene Tree for CYR61 (if available)

Paralogs for CYR61 Gene

Paralogs for CYR61 Gene

(5) SIMAP similar genes for CYR61 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYR61: view

Variants for CYR61 Gene

Sequence variations from dbSNP and Humsavar for CYR61 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9658587 - 85,582,896(+) AGATG(A/C/T)GGTTC reference, missense
rs1139740 -- 85,581,969(+) GAATC(A/C/T)CACTC reference, missense
rs1139745 -- 85,582,278(+) AGCGG(A/C)TCCCT reference, missense
rs1139746 -- 85,582,440(+) CATCC(G/T)ATACA reference, missense
rs1062805 -- 85,582,190(+) CTTGG(C/T)AAGGA reference, synonymous-codon

Variation tolerance for CYR61 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYR61 Gene

Human Gene Mutation Database (HGMD)
CYR61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYR61 Gene

Disorders for CYR61 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CYR61 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epispadias
periapical periodontitis
  • apical periodontitis
wilms tumor susceptibility-5
  • wilms tumor
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search CYR61 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CYR61

Genetic Association Database (GAD)
CYR61
Human Genome Epidemiology (HuGE) Navigator
CYR61
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYR61
genes like me logo Genes that share disorders with CYR61: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYR61 Gene

Publications for CYR61 Gene

  1. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. (PMID: 9135077) Jay P. … Berta P. (Oncogene 1997) 2 3 4 23 67
  2. Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. (PMID: 20056838) Xie J.J. … Li E.M. (Am. J. Pathol. 2010) 3 23
  3. Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin. (PMID: 20195466) Francischetti I.M. … Lukszo J. (PLoS ONE 2010) 3 23
  4. Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation. (PMID: 20233866) Goodwin C.R. … Laterra J. (Cancer Res. 2010) 3 23
  5. Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. (PMID: 20237132) Wolf N. … Gellhaus A. (Endocrinology 2010) 3 23

Products for CYR61 Gene

Sources for CYR61 Gene

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