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CYR61 Gene

protein-coding   GIFtS: 65
GCID: GC01P086046

Cysteine-Rich, Angiogenic Inducer, 61


(Previous symbol: IGFBP10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine-Rich, Angiogenic Inducer, 611 2     CCN Family Member 12 3
IGFBP101 2 3 5     IGF-Binding Protein 102 3
Insulin-Like Growth Factor-Binding Protein 102 3     Cysteine-Rich Heparin-Binding Protein 612
CCN12 3     Cysteine-Rich, Anigogenic Inducer, 612
GIG12 3     Protein CYR612
IBP-102 3     Cysteine-Rich Angiogenic Inducer 613
IGFBP-102 3     Protein GIG13

External Ids:    HGNC: 26541   Entrez Gene: 34912   Ensembl: ENSG000001428717   OMIM: 6023695   UniProtKB: O006223   

Export aliases for CYR61 gene to outside databases

Previous GC identifers: GC01P086445 GC01P085188 GC01P085334 GC01P085469 GC01P085758 GC01P084157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYR61 Gene:
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial
cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein
also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix
formation. (provided by RefSeq, Sep 2011)

GeneCards Summary for CYR61 Gene:
CYR61 (cysteine-rich, angiogenic inducer, 61) is a protein-coding gene. Diseases associated with CYR61 include epispadias, and ocular melanoma. GO annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: CYR61_HUMAN, O00622
Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound
healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis,
inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3
and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of
alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin
alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin
alpha-v/beta-3

Gene Wiki entry for CYR61 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYR61 gene promoter:
         CREB   SRF   E2F-1   E2F   deltaCREB   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYR61 promoter sequence
   Search Chromatin IP Primers for CYR61

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYR61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

CYR61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYR61 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P086046:  view genomic region     (about GC identifiers)

Start:
86,046,444 bp from pter      End:
86,049,650 bp from pter
Size:
3,207 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CYR61_HUMAN, O00622 (See protein sequence)
Recommended Name: Protein CYR61 precursor  
Size: 381 amino acids; 42027 Da
Subunit: Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin
fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds,
in vitro, ITGAV/ITGB5
Secondary accessions: O14934 O43775 Q9BZL7

Explore the universe of human proteins at neXtProt for CYR61: NX_O00622

Explore proteomics data for CYR61 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYR61 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001545.2  
    ENSEMBL proteins: 
     ENSP00000398736  

    CYR61 Human Recombinant Protein Products:

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    CYR61 Antibody Products:

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    CYR61 Assay Products:

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    Cloud-Clone Corp. ELISAs for CYR61
    Cloud-Clone Corp. CLIAs for CYR61


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR006207 Cys_knot_C
     IPR000867 IGFBP-like
     IPR012395 IGFBP_CNN
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry O00622

    ProtoNet protein and cluster: O00622

    5 Blocks protein domains:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CYR61_HUMAN, O00622
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    CYR61 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYR61_HUMAN, O00622
    Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound
    healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis,
    inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3
    and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of
    alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin
    alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin
    alpha-v/beta-3

         Genatlas biochemistry entry for CYR61:
    cysteine-rich angiogenic 61,related protein 4,immediate early gene,low affinity,expressed in embryonic tissues and
    in tumor cell lines derived from the nervous system,putatively involved in the control of cell
    proliferation,promoting angiogenesis and chondrogenesis during mouse development (see TSG1E)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008201heparin binding IEA--
    GO:0050840extracellular matrix binding IEA--
         
    CYR61 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CYR61:
     Decreased cell number and incr  Decreased viability with pacli  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cyr61):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  liver/biliary system 
     mortality/aging 

    CYR61 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYR61
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYR61

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYR61
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYR61

    miRNA
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    miRTarBase miRNAs that target CYR61:
    hsa-mir-26b-5p (MIRT030115), hsa-mir-155-5p (MIRT005484), hsa-mir-30a-3p (MIRT001764), hsa-mir-205-5p (MIRT006935), hsa-mir-124-3p (MIRT023099)

    Block miRNA regulation of human, mouse, rat CYR61 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYR61 (see all 21):
    hsa-miR-181c hsa-miR-16-1* hsa-miR-944 hsa-miR-221 hsa-miR-570 hsa-miR-3161 hsa-miR-29a* hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCYR61 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYR61
    Predesigned siRNA for gene silencing in human, mouse, rat CYR61

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CYR61 (NM_001554)
    Sino Biological Human cDNA Clone for CYR61
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYR61
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYR61

    Cell Line
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    ESI BIO PureStem Progenitor for CYR61: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYR61


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYR61_HUMAN, O00622: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CYR61 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYR61 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1G protein signaling Ras family GTPases in kinase cascades scheme
    Oncostatin M Signaling Pathway0.37
    2RhoA signaling pathway
    RhoA signaling pathway
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    4Hypertrophy Model
    Hypertrophy Model
    5Angiogenesis (CST)
    Angiogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CYR61
        Angiogenesis
    Adhesion

    5 BioSystems Pathways for CYR61
        Oncostatin M Signaling Pathway
    Hypertrophy Model
    amb2 Integrin signaling
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    RhoA signaling pathway




    CYR61 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYR61: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Nephrotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYR61

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CYR61 (O006223 ENSP000003987364) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVP067563, ENSP000002610234I2D: score=3 STRING: ENSP00000261023
    ITGB5P180843, ENSP000002961814I2D: score=3 STRING: ENSP00000296181
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0002041intussusceptive angiogenesis IEA--
    GO:0003181atrioventricular valve morphogenesis IEA--

    CYR61 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYR61

    Selected Novoseek inferred chemical compound relationships for CYR61 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lm 609 59.8 2 9446626 (2)
    matrigel 43 1 11059746 (1)
    vegf 39.2 40 17343196 (10), 20137309 (7), 16609965 (6), 15649872 (3) (see all 10)
    cysteine 38.3 10 11287419 (1), 16774841 (1), 9135077 (1), 15579080 (1) (see all 8)
    estrogen 32 26 17601910 (4), 11840342 (4), 11356703 (3), 18923163 (2) (see all 11)
    prostaglandin 17 1 12724323 (1)
    heparin 12.8 8 1782153 (2), 11584015 (2), 18575751 (1), 9184077 (1) (see all 5)
    prostacyclin 8.07 3 10446209 (1), 12921857 (1)
    oligonucleotide 4.97 2 15649872 (1), 14711396 (1)
    actinomycin d 0.149 2 12374462 (1), 11356703 (1)



    CYR61 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYR61 gene: 
    NM_001554.4  

    Unigene Cluster for CYR61:

    Cysteine-rich, angiogenic inducer, 61
    Hs.8867  [show with all ESTs]
    Unigene Representative Sequence: NM_001554
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451137(uc001dle.3) ENST00000480413
    miRNA
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    hsa-miR-181c hsa-miR-16-1* hsa-miR-944 hsa-miR-221 hsa-miR-570 hsa-miR-3161 hsa-miR-29a* hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCYR61 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CYR61
      QuantiFast Probe-based Assays in human, mouse, rat CYR61

    Additional mRNA sequence: 

    AF003114.1 AF003594.1 AF031385.1 AK096420.1 AK223385.1 AK295430.1 AK314571.1 AL832891.1 
    BC001271.1 BC009199.2 BC016952.1 CR536519.1 U62015.1 Y11307.1 Y12084.1 Z50168.1 
    Z97068.1 Z98053.1 

    24 DOTS entries:

    DT.100806131  DT.100675189  DT.455407  DT.92454887  DT.87017204  DT.100031598  DT.100675191  DT.95269061 
    DT.91705871  DT.92454881  DT.121334657  DT.121334663  DT.92361094  DT.100031596  DT.100688758  DT.95269073 
    DT.101985398  DT.121334543  DT.92413877  DT.121334647  DT.92454883  DT.97762400  DT.100800749  DT.92454886 

    Selected AceView cDNA sequences (see all 608):

    AA852067 BG163309 BC009199 BU627106 CR622169 AI678385 AW630891 CR609236 
    AW020058 BQ719732 BQ183755 BQ774402 CA412093 AI469592 BG698245 AW518670 
    BE747258 AI755211 AA296896 AA081399 AI627367 BM969418 BQ002412 BG679464 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CYR61    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -                           
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for CYR61

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYR61 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGTCTGTG
    CYR61 Expression
    About this image


    CYR61 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Inner Cell Mass Cells Inner Cell Mass
             Line H9 (Naive)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Kidney (Urinary System)
             Metanephros
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    CYR61 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYR61 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8867
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYR61: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Nephrotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYR61
    OriGene qSTAR qPCR primer pairs in human, mouse for CYR61
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYR61
    QuantiTect SYBR Green Assays in human, mouse, rat CYR61
    QuantiFast Probe-based Assays in human, mouse, rat CYR61
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYR61

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYR61 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyr611 , 5 cysteine rich protein 611, 5 88.95(n)1
    92.84(a)1
      3 (70.18 cM)5
    160071  NM_010516.21  NP_034646.11 
     1456469715 
    chicken
    (Gallus gallus)
    Aves CYR611 cysteine-rich, angiogenic inducer, 61 78.14(n)
    83.87(a)
      429089  NM_001031563.1  NP_001026734.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYR616
    cysteine-rich, angiogenic inducer, 61
    79(a)
    1 ↔ 1
    GL343194.1(10494567-10499263)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642372 hypothetical protein MGC64237 78.27(n)    BC056838.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC057506.12   -- 79.97(n)    BC057506.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ccn6
    Ccn
    18(a)
    1 → many
    3L(17683115-17741939)


    ENSEMBL Gene Tree for CYR61 (if available)
    TreeFam Gene Tree for CYR61 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYR61 gene
    WISP22  NOV2  CTGF2  WISP32  WISP12  
    5 SIMAP similar genes for CYR61 using alignment to 3 protein entries:     CYR61_HUMAN (see all proteins):
    CTGF    NOV    WISP3    LIBC    WISP1

    CYR61 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYR61 (see all 139)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs96585831,2
    C,F--86046087(+) CCCTTC/GCCAAC 1 -- us2k12Minor allele frequency- G:0.02NS WA 294
    rs1123194051,2
    C,F--86046147(+) TGGGAG/CACACA 1 -- us2k13Minor allele frequency- C:0.50WA NA 6
    rs1135673061,2
    C,F--86046151(+) ACACAG/CACACA 1 -- us2k12Minor allele frequency- C:0.50WA NA 4
    rs671575531,2
    C--86046180(+) CACACA/CCCCCG 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs587261721,2
    C--86046181(+) CACCC-/A/CC  
            
    CCCGA
    1 -- us2k11NA 2
    rs782001851,2
    C--86046182(+) CACCCA/CCCGAA 1 -- us2k10--------
    rs1120080721,2
    C--86046219(+) AGACAG/CACACA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs127481821,2
    C--86046227(+) acacaC/Gacaca 1 -- us2k10--------
    rs1921710231,2
    --86046279(+) ACACAA/CACAAA 1 -- us2k10--------
    rs22971401,2
    C,F--86046561(+) CGGGCA/CCACCG 1 -- ut516Minor allele frequency- C:0.44EA NA CSA WA 1736

    HapMap Linkage Disequilibrium report for CYR61 (86046444 - 86049650 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CYR61: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYR61
    DNA2.0 Custom Variant and Variant Library Synthesis for CYR61

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602369    OMIM disorders: --

    Selected diseases for CYR61 (see all 57):    
    About MalaCards
    epispadias    ocular melanoma    intussusception    embryonal rhabdomyosarcoma
    nephroblastoma    adenoid cystic carcinoma    leiomyoma    osteonecrosis
    proliferative diabetic retinopathy    rhabdomyosarcoma    adenoiditis    hypospadias
    diabetic retinopathy    sporadic breast cancer    wilms tumor    endometriosis
    esophageal squamous cell carcinoma    synovitis    neurofibromatosis    vascular disease

    1 disease from the University of Copenhagen DISEASES database for CYR61:
    Nephroblastoma

    CYR61 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CYR61 gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 68.7 19 12064632 (1), 15611078 (1), 20332765 (1), 8666280 (1) (see all 15)
    neovascularization 57.2 6 9600969 (2), 12364323 (1), 15044605 (1), 10821835 (1)
    tumors 40.2 103 11751417 (4), 18794119 (3), 11840342 (3), 17698398 (3) (see all 41)
    rhabdomyosarcoma 34.9 1 14996733 (1)
    breast cancer 34.5 66 11840342 (10), 18575751 (9), 19244129 (4), 15592521 (4) (see all 15)
    glioma 33.7 15 20233866 (5), 15041728 (4), 18004727 (2), 19147534 (1) (see all 5)
    cancer 30 39 20172544 (3), 19180570 (3), 15077166 (1), 16266990 (1) (see all 18)
    endometriosis 29.9 8 16481591 (5), 15044605 (2)
    endometrial cancer 29.2 14 19007976 (5), 15471875 (4), 17601910 (1)
    metastasis 29.1 27 15737847 (5), 18794119 (3), 15526358 (2), 19159527 (2) (see all 13)

    Genetic Association Database (GAD): CYR61
    Human Genome Epidemiology (HuGE) Navigator: CYR61 (4 documents)

    Export disorders for CYR61 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYR61 gene, integrated from 10 sources (see all 285):
    (articles sorted by number of sources associating them with CYR61)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. (PubMed id 9135077)1, 2, 3, 9 Jay P....Berta P. (Oncogene 1997)
    2. CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. (PubMed id 11287419)1, 2, 9 Grzeszkiewicz T.M.... Lau L.F. (J. Biol. Chem. 2001)
    3. Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. (PubMed id 10821835)1, 2, 9 Chen N.... Lau L.F. (J. Biol. Chem. 2000)
    4. Adhesion of human umbilical vein endothelial cells to the immediate- early gene product Cyr61 is mediated through integrin alphavbeta3. (PubMed id 9446626)1, 2, 9 Kireeva M.L.... Lau L.F. (J. Biol. Chem. 1998)
    5. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. (PubMed id 11584015)1, 2, 9 Chen C.-C.... Lau L.F. (J. Biol. Chem. 2001)
    6. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). (PubMed id 10446209)1, 2, 9 Jedsadayanmata A.... Lam S.C. (J. Biol. Chem. 1999)
    7. Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. (PubMed id 10852911)1, 2, 9 Albrecht C....Nitsch R.M. (J. Biol. Chem. 2000)
    8. Organization and expression of the Cyr61 gene in normal human fibroblasts. (PubMed id 11810026)1, 2, 9 Leng E.... Sadowski I. (J. Biomed. Sci. 2002)
    9. CYR61 polymorphisms are associated with plasma HDL-cholesterol levels in obese individuals. (PubMed id 17718860)1, 4, 9 Bouchard L....Vohl M.C. (Clin. Genet. 2007)
    10. Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system. (PubMed id 9536281)1, 2, 9 Martinerie C.... Perbal B. (Mol. Pathol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3491 HGNC: 2654 AceView: CYR61 Ensembl:ENSG00000142871 euGenes: HUgn3491
    ECgene: CYR61 H-InvDB: CYR61

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYR61 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYR61 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyr61/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYR61 gene:
    Search GeneIP for patents involving CYR61

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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