CYP8B1 Gene
protein-coding GIFtS: 54
GCID: GC03M042888
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|
cytochrome P450, family 8, subfamily B, polypeptide 1(Previous names: cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase),...)
| |
Aliases
for CYP8B1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 8, Subfamily B, Polypeptide 11 2 | | CYPVIIIB12 3 | | CYP121 2 3 5 | | 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase2 | | Cytochrome P450, Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase), Polypeptide 11 2 | | 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase2 | | Cytochrome P450 8B12 3 | | CP8B2 | | Sterol 12-Alpha-Hydroxylase2 3 | | EC 1.14.13.953 | | 7-Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase2 3 | | |
Export aliases for CYP8B1 gene to outside databasesPrevious GC identifers: GC03M042218 GC03M042094 GC03M042732 GC03M042874 |
Summaries
for CYP8B1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP8B1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these twosteroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in thebile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it isintronless. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP8B1_HUMAN, Q9UNU6Function: Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-oneinto 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid andchenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27steroids
Gene Wiki entry for CYP8B1
|
Genomic Views
for CYP8B1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP8B1 gene promoter:
c-Fos AP-1 ATF-2 Pax-2a HEN1 Pax-2b ARP-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP8B1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP8B1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.1 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p22.1CYP8B1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M042888: view genomic region
(about GC identifiers)
Start:
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42,897,497 bp from pter |
End:
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42,917,633 bp from pter |
Size:
|
20,137 bases |
Orientation:
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minus strand |
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Proteins
for CYP8B1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP8B1_HUMAN, Q9UNU6 (See
protein sequence)Recommended Name: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Size: 501 amino acids; 58068 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-passmembrane protein
Secondary accessions: B2RCY3 O75958 Q6NWT2 Q6NWT3Explore the universe of human proteins at neXtProt for CYP8B1: NX_Q9UNU6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UNU6
CYP8B1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004382.2
ENSEMBL proteins: ENSP00000404499 ENSP00000318867 Reactome Protein details: Q9UNU6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CYP8B1 for ontologies About GeneDecksing
CYP8B1 Antibody Products:
Assay Products for CYP8B1: |
Protein
Domains /
Families
for CYP8B1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP8B1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UNU6ProtoNet protein and cluster: Q9UNU6 1 Blocks protein family: IPB002403 E-class P450 group IV signature
UniProtKB/Swiss-Prot: CP8B1_HUMAN, Q9UNU6Similarity: Belongs to the cytochrome P450 family |
Function
for CYP8B1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP8B1_HUMAN, Q9UNU6Function: Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-oneinto 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid andchenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27steroidsCatalytic activity: 7-alpha-hydroxycholest-4-en-3-one + NADPH + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one +NADP(+) + H(2)O Genatlas biochemistry entry for CYP8B1:cytochrome P450 subfamily VIIIB polypeptide 1,hepatic microsomal enzyme,involved in bile synthesis,controlling theratio of cholic acid over chenodeoxycholic cholic acid in bile
Enzyme Number (IUBMB): EC 1.14.13.951
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP8B1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CYP8B1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP8B1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP8B1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004497 | monooxygenase activity |
-- | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0008397 | sterol 12-alpha-hydroxylase activity |
TAS | 10051404 | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
-- | -- |
CYP8B1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Cyp8b1tm1Rus for CYP8B1
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cyp8b1):
CYP8B1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CYP8B1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of bile acids and bile salts | | | 2 | Cytochrome P450 - arranged by substrate type | | | 3 | Metabolism | | | 4 | Biological oxidations | | | 5 | Endogenous sterols | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for CYP8B1
5/12 
Reactome Pathways for CYP8B1 (see all 12)
3 
Kegg Pathways (Kegg details for CYP8B1):
CYP8B1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP8B1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CYP8B1 (ENSP000003188674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006699 | bile acid biosynthetic process |
TAS | -- | | GO:0006805 | xenobiotic metabolic process |
TAS | -- | | GO:0008206 | bile acid metabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
CYP8B1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP8B1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP8B1 for compounds About GeneDecksing
 Browse Tocris compounds for CYP8B1
3 HMDB Compounds for CYP8B1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- | | NADP | Adenine-nicotinamide dinucleotide phosphate (see all 18) | 53-59-8 | -- | | NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
4 Novoseek chemical compound relationships for CYP8B1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholic acid |
88.2 |
7 |
16271991 (1), 11741989 (1), 10051404 (1), 17585019 (1) (see all 7) |
| chenodeoxycholic acid |
87.2 |
2 |
10051404 (1), 15550563 (1) |
| sterol |
78.3 |
11 |
10051404 (2), 14643796 (2), 15550563 (2), 16937432 (1) (see all 8) |
| cholesterol |
52 |
6 |
11535594 (2), 16937432 (1), 10051404 (1), 17585019 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about CYP8B1 / CP8B1
|
Transcripts
for CYP8B1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP8B1 gene: NM_004391.2 Unigene Cluster for CYP8B1: Cytochrome P450, family 8, subfamily B, polypeptide 1 Hs.447793 [show with all ESTs]Unigene Representative Sequence: NM_0043912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000437102 ENST00000316161(uc003cmh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP8B1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP8B1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP8B1 (NM_004391) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP8B1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP8B1 |
Additional cDNA sequence: AF090318.1 AK315330.1 BC067434.1 BC067441.1 BC067442.1 BC067443.1 BC067444.1 2 DOTS entries: DT.101982500 DT.101982701 24/36 AceView cDNA sequences (see all 36): BC067442 R97419 CK032853 CK032851 CF271954 CF271957 AF090318 CF271944 CF271950 NM_004391 BC067434 CF271955 BX119155 BC067443 CK130227 CK130226 CK032852 CK032850 CF271952 BC067444 CF271956 BC067441 CF271951 BX496225
GeneLoc Exon Structure
|
Expression
for CYP8B1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP8B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATTTTATT
About this image
See CYP8B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP8B1
SOURCE GeneReport for Unigene cluster: Hs.447793
UniProtKB/Swiss-Prot: CP8B1_HUMAN, Q9UNU6Tissue specificity: Liver
SABiosciences Expression via Pathway-Focused PCR Array including CYP8B1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP8B1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP8B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP8B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP8B1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP8B1 |
Orthologs
for CYP8B1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CYP8B1 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for CYP8B1 (if available)
TreeFam Gene Tree for CYP8B1 (if available) |
Paralogs
for CYP8B1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP8B1 gene
- CYP39A12 PTGIS2 CYP7A12 CYP7B12
4 SIMAP similar genes for CYP8B1 using alignment to 2 protein entries: CP8B1_HUMAN (see all proteins):CYP7A1 PTGIS PGIS CYP7B1
CYP8B1 for paralogs About GeneDecksing
|
Genomic Variants
for CYP8B1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP8B1 (42897497 - 42917633 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP8B1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP8B1 |
|
Disorders
/ Diseases
for CYP8B1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP8B1 for disorders About GeneDecksing
OMIM gene information: 602172
OMIM disorders: --
9  diseases for CYP8B1: About MalaCardscerebrotendinous xanthomatosis cholesterol xanthomatosis hearing loss
cholestasis tuberculosis thyroiditis hepatitis
mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for CYP8B1:Cerebrotendinous xanthomatosis Human Genome Epidemiology (HuGE) Navigator: CYP8B1 (3 documents)
Export disorders for CYP8B1 gene to outside databases
|
Publications
for CYP8B1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP8B1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with CYP8B1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and chromosomal assignment of the sterol 12alpha- hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P- 450 gene devoid of introns. (PubMed id 10051404)1, 2, 3, 9 Gaafvels M.... Eggertsen G. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. (PubMed id 11535594)1, 9 Zhang M. and Chiang J.Y. (2001)
- Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones. (PubMed id 17585019)1, 9 Li Y....Shay N.F. (2007)
- Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes. (PubMed id 16937432)1, 9 Ellis E.C. (2006)
- [Association of single nucleotide polymorphism in huma n CYP8B1 gene with gallstone disease]. (PubMed id 22093981)1 Qin J....Zhang S.D. (2011)
- Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1 Ross C.J....Hayden M.R. (2009)
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1 Lu Y....Boer J.M. (2008)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. (PubMed id 15891895)1 Wang J....Gafvels M. (2005)
|
External Searches for CYP8B1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP8B1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP8B1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP8B1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP8B1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYP8B1 gene:
Search GeneIP for patents involving CYP8B1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP8B1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP8B1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP8B1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP8B1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP8B1 | | OriGene 3'-UTR Clone for CYP8B1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP8B1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP8B1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP8B1 | | OriGene Custom Protein Services for CYP8B1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP8B1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP8B1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP8B1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP8B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP8B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP8B1 |
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| | | | Search Tocris compounds for CYP8B1 |
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 | | | CYP8B1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP8B1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CYP8B1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP8B1 |
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