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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP4Z2P Gene

pseudogene GIFtS: 33
GCID: GC01M047309

cytochrome P450, family 4, subfamily Z, polypeptide 2 pseudogene

Explore 2 diseases affiliated with
CYP4Z2P via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Cytochrome P450, Family 4, Subfamily Z, Polypeptide 2 Pseudogene¹ ²
FLJ40054¹

External Ids:	HGNC: 24426¹	Entrez Gene: 163720²	Ensembl: ENSG00000154198⁷	UniProtKB: Q8N1L4³

ORGUL members:	fRNAdb¹⁰:FR175425
	NCBI:XR_000161
	NONCODE:n381122 n385936
	RNAdb:LIT2048

Export aliases for CYP4Z2P gene to outside databases

Previous GC identifers: GC01M046695 GC01M046678 GC01M046693 GC01M047035 GC01M045439

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

fRNAdb sequence ontology for CYP4Z2P:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP4Z2P gene promoter:
LHX3b/Lhx3b AML1a Pax-5 Tal-1beta E47 Arnt Gfi-1 RORalpha1 LHX3a/Lhx3a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CYP4Z2P

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4Z2P

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33

CYP4Z2P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4Z2P gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M047309: view genomic region (about GC identifiers)

Start:	47,308,767 bp from pter	End:	47,366,147 bp from pter
Size:	57,381 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

FR0175425
n381122
n385936

lncRNA
Full Legend

47323905 47345026 47366147 chr1

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP4Z2_HUMAN, Q8N1L4 (See protein sequence)

Recommended Name: Putative inactive cytochrome P450 family member 4Z2

Size: 340 amino acids; 40159 Da

Cofactor: Heme group (By similarity)

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Caution: Could be the product of a pseudogene. In contrast to other members of the family, it is shorter at the

C-terminus and lacks the heme-binding sites

Secondary accessions: Q66ZJ5

Alternative splicing: 2 isoforms: Q8N1L4-1 Q8N1L4-2

Explore the universe of human proteins at neXtProt for CYP4Z2P: NX_Q8N1L4

CYP4Z2P Protein expression data from MOPED and PaxDb: About this image

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

CYP4Z2P for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP4Z2P for domains About GeneDecksing

1 InterPro domain/family:

IPR001128 Cyt_P450

Graphical View of Domain Structure for InterPro Entry Q8N1L4

ProtoNet protein and cluster: Q8N1L4

UniProtKB/Swiss-Prot: CP4Z2_HUMAN, Q8N1L4

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	--
GO:0020037	heme binding	IEA	--

CYP4Z2P for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP4Z2P

1 Interacting protein for CYP4Z2P (Q8N1L4³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GABARAPL1	Q9H0R8³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP4Z2P

1 HMDB Compound for CYP4Z2P About this table

Compound	Synonyms	CAS #	PubMed Ids
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--

Search CenterWatch for drugs/clinical trials and news about CYP4Z2P

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

Unigene Cluster for CYP4Z2P:

Cytochrome P450, family 4, subfamily Z, polypeptide 2 pseudogene

Hs.591431 [show with all ESTs]

Unigene Representative Sequence: AK097373

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000505841(uc001cqo.1 uc009vyn.1) ENST00000423332

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Additional cDNA sequence:

AK097373.1 NR_002788.2

2 DOTS entries:

DT.100742965 DT.40314457

3 AceView cDNA sequences:

AK097373 AY262057 AY696295

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP4Z2P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGATCTTTG

About this image
See CYP4Z2P Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4Z2P

SOURCE GeneReport for Unigene cluster: Hs.591431

UniProtKB/Swiss-Prot: CP4Z2_HUMAN, Q8N1L4

Tissue specificity: Detected at low levels in mammary gland and mammary carcinoma

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for CYP4Z2P (if available)
TreeFam Gene Tree for CYP4Z2P (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9429212^1,2	C,F	--	45459913(+)	`CATCAT/CAACAA`	1	--	int¹		5		NA WA CSA	9
rs71645835^1,2	C,F	--	45460075(+)	`TGATCC/TAAAAC`	1	--	int¹		2		NA	4
rs2653935^1,2	C,F,A	--	45460238(+)	`acaaaG/Tatttt`	1	--	int¹		3		NA	6
rs2742095^1,2	C,F	--	45460256(+)	`cataaG/Acaaaa`	1	--	int¹		2		NA	4
rs13156714^1,2	C	--	45461455(-)	`gcatcG/Cctgtc`	1	--	int¹		1		NA	2
rs11745134^1,2	C,A,H	--	45461510(-)	`taaatG/Tccctg`	1	--	int¹		1		NA	2
rs10044037^1,2	C,H	--	45461876(-)	`gaataT/Ctcttc`	1	--	int¹		1		NA	2
rs13155816^1,2	C	--	45461955(-)	`gggatG/Agcatt`	1	--	int¹		1		NA	2
rs144473824^1,2	C,	--	47308410(+)	`CCCCC-/TCTCTG`	1	--	ds500¹		0	--	--	--	--
rs59838435^1,2	C,F,	--	47308414(+)	`CTCTCT/AGCTAA`	1	--	ds500¹		2		WA CSA	4

HapMap Linkage Disequilibrium report for CYP4Z2P (47308767 - 47366147 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP4Z2P: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP4Z2P for disorders About GeneDecksing

2 diseases for CYP4Z2P: About MalaCards

breast carcinoma carcinoma

Export disorders for CYP4Z2P gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP4Z2P gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYP4Z2P)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PubMed id 15059886)^{1, 2, 3} Rieger M.A.... Weigle B. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)¹ Nelson D.R....Nebert D.W. (2004)
(PubMed id 15608161)¹⁰

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 163720	HGNC: 24426	AceView: CYP4Z2P	Ensembl:ENSG00000154198	euGenes: HUgn163720
ECgene: CYP4Z2P	H-InvDB: CYP4Z2P

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for CYP4Z2P gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CYP4Z2P gene:
Search GeneIP for patents involving CYP4Z2P

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CYP4Z2P Gene

cytochrome P450, family 4, subfamily Z, polypeptide 2 pseudogene

Aliases
for CYP4Z2P gene

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CYP4Z2P Gene

cytochrome P450, family 4, subfamily Z, polypeptide 2 pseudogene

Aliasesfor CYP4Z2P gene

Summariesfor CYP4Z2P gene

Genomic Viewsfor CYP4Z2P gene

Proteinsfor CYP4Z2P gene

Protein Domains /Familiesfor CYP4Z2P gene

Functionfor CYP4Z2P gene

Pathways & Interactionsfor CYP4Z2P gene

Drugs & Compoundsfor CYP4Z2P gene

Transcriptsfor CYP4Z2P gene

Expression for CYP4Z2P gene

Orthologsfor CYP4Z2P gene

Paralogsfor CYP4Z2P gene

Genomic Variantsfor CYP4Z2P gene

Disorders / Diseasesfor CYP4Z2P gene

Publicationsfor CYP4Z2P gene

External Searches for CYP4Z2P gene

Genome Databases showing CYP4Z2P gene

Other Databases showing CYP4Z2P gene

Specialized Databases showing CYP4Z2P gene

Intellectual Propertyfor CYP4Z2P gene

Productsfor CYP4Z2P gene

View Random Gene

Aliases
for CYP4Z2P gene

Summaries
for CYP4Z2P gene

Genomic Views
for CYP4Z2P gene

Proteins
for CYP4Z2P gene

Protein Domains /
Families
for CYP4Z2P gene

Function
for CYP4Z2P gene

Pathways & Interactions
for CYP4Z2P gene

Drugs & Compounds
for CYP4Z2P gene

Transcripts
for CYP4Z2P gene

Expression
for CYP4Z2P gene

Orthologs
for CYP4Z2P gene

Paralogs
for CYP4Z2P gene

Genomic Variants
for CYP4Z2P gene

Disorders / Diseases
for CYP4Z2P gene

Publications
for CYP4Z2P gene

Intellectual Property
for CYP4Z2P gene

Products
for CYP4Z2P gene