Aliases for CYP4Z2P Gene
Aliases for CYP4Z2P Gene
External Ids for CYP4Z2P Gene
- HGNC: 24426
- Entrez Gene: 163720
- Ensembl: ENSG00000154198
- UniProtKB: Q8N1L4
Previous GeneCards Identifiers for CYP4Z2P Gene
- GC01M046695
- GC01M046678
- GC01M046693
- GC01M047035
- GC01M047309
- GC01M045439
Summaries for CYP4Z2P Gene
GeneCards Summary for CYP4Z2P Gene
CYP4Z2P (Cytochrome P450 Family 4 Subfamily Z Member 2, Pseudogene) is a Pseudogene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4Z2P Gene
Genomics for CYP4Z2P Gene
Regulatory Elements for CYP4Z2P Gene
Enhancers for CYP4Z2P Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G046903 | 0.6 | ENCODE | 0.7 | -3.2 | -3249 | 0.2 | CTBP1 ZNF687 CREB1 MNT DPF2 PRDM1 FOXA1 | CYP4Z2P GC01P046925 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CYP4Z2P on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CYP4Z2P gene promoter:
Regulatory Element Products
Genomic Location for CYP4Z2P Gene
- Chromosome:
- 1
- Start:
- 46,843,095 bp from pter
- End:
- 46,900,475 bp from pter
- Size:
- 57,381 bases
- Orientation:
- Minus strand
Genomic View for CYP4Z2P Gene
Genes around CYP4Z2P on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p33 by Ensembl
- 1p33 by Entrez Gene
- 1p33 by HGNC
CYP4Z2P Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP4Z2P Gene
Proteins for CYP4Z2P Gene
-
Protein details for CYP4Z2P Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N1L4-CP4Z2_HUMAN
- Recommended name:
- Putative inactive cytochrome P450 family member 4Z2
- Protein Accession:
- Q8N1L4
- Q66ZJ5
Protein attributes for CYP4Z2P Gene
- Size:
- 340 amino acids
- Molecular mass:
- 40159 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Post-translational modifications for CYP4Z2P Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for CYP4Z2P
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CYP4Z2P
- Origene Custom Protein Services for CYP4Z2P
- Search GeneTex for Proteins for CYP4Z2P
Assay Products
No data available for DME Specific Peptides for CYP4Z2P Gene
Domains & Families for CYP4Z2P Gene
Gene Families for CYP4Z2P Gene
Suggested Antigen Peptide Sequences for CYP4Z2P Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N1L4- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP4Z2P Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
| GO:0020037 | heme binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP4Z2P
-
- Search ViGene Biosciences for CYP4Z2P
CRISPR Products
- Browse CRISPR knockouts for CYP4Z2P
miRNA Products
- Search ViGene Biosciences for CYP4Z2P
Inhibitory RNA Products
- Search ViGene Biosciences for CYP4Z2P
Clone Products
- GenScript: Custom all cDNA clones Services for CYP4Z2P
- VectorBuilder custom plasmid, inducible vectors for CYP4Z2P
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP4Z2P
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for CYP4Z2P
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4Z2P Gene
Localization for CYP4Z2P Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP4Z2P Gene
- Membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS for CYP4Z2P Gene
Pathways & Interactions for CYP4Z2P Gene
No Data Available
Interacting Proteins for CYP4Z2P Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| GABARAPL1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CYP4Z2P Gene
Transcripts for CYP4Z2P Gene
mRNA/cDNA for CYP4Z2P Gene
- (2) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYP4Z2P Gene
CRISPR Products
- Browse CRISPR knockouts for CYP4Z2P
miRNA Products
- Search ViGene Biosciences for CYP4Z2P
Inhibitory RNA Products
- Search ViGene Biosciences for CYP4Z2P
Clone Products
- GenScript: Custom all cDNA clones Services for CYP4Z2P
- VectorBuilder custom plasmid, inducible vectors for CYP4Z2P
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP4Z2P
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CYP4Z2P Gene
mRNA differential expression in normal tissues according to GTEx for CYP4Z2P Gene
This gene is overexpressed in Breast - Mammary Tissue (x16.1).
NURSA nuclear receptor signaling pathways regulating expression of CYP4Z2P Gene:
CYP4Z2PSOURCE GeneReport for Unigene cluster for CYP4Z2P Gene:
Hs.591431mRNA Expression by UniProt/SwissProt for CYP4Z2P Gene:
Q8N1L4-CP4Z2_HUMAN
Tissue specificity:
Detected at low levels in mammary gland and mammary carcinoma.
Primer Products
-
OriGene qPCR primer pairs for CYP4Z2P
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4Z2P Gene
Orthologs for CYP4Z2P Gene
No data available for Orthologs for CYP4Z2P Gene
Paralogs for CYP4Z2P Gene
(13) SIMAP similar genes for CYP4Z2P Gene using alignment to 1 proteins:
No data available for Paralogs for CYP4Z2P Gene
Variants for CYP4Z2P Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049269 | -- | 46,900,827(+) | TACTG(C/T)AGTCT | upstream-variant-2KB | |
| rs1000106740 | -- | 46,852,885(+) | AAGAA(A/G)TTTAA | intron-variant | |
| rs1000118682 | -- | 46,846,511(+) | GCCTC(C/G)CTCAC | intron-variant | |
| rs1000137628 | -- | 46,890,231(+) | TATGA(C/T)GACAC | intron-variant | |
| rs1000200991 | -- | 46,873,645(+) | AGGTG(-/C)TTGGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv160n100 | CNV | gain | 25217958 |
| esv2670875 | CNV | deletion | 23128226 |
| esv2763300 | CNV | gain | 21179565 |
| esv3585938 | CNV | gain | 21293372 |
| esv3585941 | CNV | loss | 21293372 |
| esv3585942 | CNV | loss | 21293372 |
| esv3585943 | CNV | gain | 21293372 |
| nsv1009338 | CNV | gain | 25217958 |
| nsv525401 | CNV | loss | 19592680 |
| nsv945927 | CNV | duplication | 23825009 |
Relevant External Links for CYP4Z2P Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CYP4Z2P
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CYP4Z2P Gene
Disorders for CYP4Z2P Gene
Relevant External Links for CYP4Z2P
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CYP4Z2P
No disorders were found for CYP4Z2P Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4Z2P Gene
Publications for CYP4Z2P Gene
- Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PMID: 15059886) Rieger M.A. … Weigle B. (Cancer Res. 2004) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1. (PMID: 25701119) Zheng L. … Xi T. (Breast Cancer Res. Treat. 2015) 3 64
- An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
- Pseudogene CYP4Z2P 3'UTR promotes angiogenesis in breast cancer. (PMID: 25281903) Zheng L. … Xi T. (Biochem. Biophys. Res. Commun. 2014) 3 64
Products for CYP4Z2P Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Browse Proteins and Enzymes
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CYP4Z2P
- Origene Custom Protein Services for CYP4Z2P
- Browse OriGene Inhibitory RNA Products For CYP4Z2P
- OriGene qPCR primer pairs for CYP4Z2P
- Browse CRISPR knockouts for CYP4Z2P
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYP4Z2P
- GenScript: Custom all cDNA clones Services for CYP4Z2P
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- GenScript Custom overexpressing Cell Line Services for CYP4Z2P
- Browse GenScript CRISPR for CYP4Z2P
- Design optimal peptide antigens
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP4Z2P
- VectorBuilder custom plasmid, inducible vectors for CYP4Z2P
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP4Z2P
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CYP4Z2P Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer