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Aliases for CYP4Z1 Gene

Aliases for CYP4Z1 Gene

  • Cytochrome P450 Family 4 Subfamily Z Member 1 2 3 5
  • Cytochrome P450, Family 4, Subfamily Z, Polypeptide 1 2 3
  • CYPIVZ1 3 4
  • Cytochrome P450 4Z1 3
  • EC 1.14.14.1 4
  • CYP4A20 3

External Ids for CYP4Z1 Gene

Previous GeneCards Identifiers for CYP4Z1 Gene

  • GC01P046923
  • GC01P046903
  • GC01P046902
  • GC01P047245
  • GC01P047305
  • GC01P047533
  • GC01P045649

Summaries for CYP4Z1 Gene

Entrez Gene Summary for CYP4Z1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4Z1 Gene

CYP4Z1 (Cytochrome P450 Family 4 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4X1.

Gene Wiki entry for CYP4Z1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4Z1 Gene

Genomics for CYP4Z1 Gene

Regulatory Elements for CYP4Z1 Gene

Enhancers for CYP4Z1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G047030 1 Ensembl ENCODE 9.1 -36.4 -36362 1.4 NFIB ZNF76 FEZF1 ZNF7 ZNF366 ZBTB48 FOS ZNF600 PRDM10 ZNF10 POMGNT1 CYP4Z1 CYP4A22 CYP4X1 GC01M047004
GH01G047107 0.8 Ensembl ENCODE 10.7 +40.7 40677 2.0 CEBPG HNF4A FOS ZIC2 PRDM1 CYP4A22 CYP4A22-AS1 LINC00853 CYP4Z1 GC01M047099 LOC100533626
GH01G046519 1.6 FANTOM5 Ensembl ENCODE 4.9 -545.8 -545841 3.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS EFCAB14-AS1 DMBX1 IPP KNCN EFCAB14 TEX38 ATPAF1 NSUN4 MKNK1 CYP4Z1
GH01G047649 1.1 Ensembl ENCODE 5.2 +583.9 583911 3.3 FOXA2 ZNF133 ZSCAN4 KLF17 BMI1 FOS EGR2 CEBPB NR2F2 SREBF1 CYP4Z1 GC01P047675 GC01P047570
GH01G047707 0.6 dbSUPER 4.2 +640.5 640523 1.1 ZFHX2 SMARCA4 EGR1 SUZ12 ZNF133 CBX2 EZH2 LINC01738 CYP4Z1 GC01P047709 PIR52707
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP4Z1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4Z1 Gene

Chromosome:
1
Start:
47,067,448 bp from pter
End:
47,118,320 bp from pter
Size:
50,873 bases
Orientation:
Plus strand

Genomic View for CYP4Z1 Gene

Genes around CYP4Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4Z1 Gene

Proteins for CYP4Z1 Gene

  • Protein details for CYP4Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W10-CP4Z1_HUMAN
    Recommended name:
    Cytochrome P450 4Z1
    Protein Accession:
    Q86W10
    Secondary Accessions:
    • Q5VVE4

    Protein attributes for CYP4Z1 Gene

    Size:
    505 amino acids
    Molecular mass:
    59086 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4Z1 Gene

Post-translational modifications for CYP4Z1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4Z1 Gene

Domains & Families for CYP4Z1 Gene

Gene Families for CYP4Z1 Gene

Protein Domains for CYP4Z1 Gene

Suggested Antigen Peptide Sequences for CYP4Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W10

UniProtKB/Swiss-Prot:

CP4Z1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4Z1: view

Function for CYP4Z1 Gene

Molecular function for CYP4Z1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.

Enzyme Numbers (IUBMB) for CYP4Z1 Gene

Gene Ontology (GO) - Molecular Function for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

Phenotypes for CYP4Z1 Gene

genes like me logo Genes that share phenotypes with CYP4Z1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4Z1 Gene

Localization for CYP4Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4Z1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
plasma membrane 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

Pathways & Interactions for CYP4Z1 Gene

genes like me logo Genes that share pathways with CYP4Z1: view

Pathways by source for CYP4Z1 Gene

2 BioSystems pathways for CYP4Z1 Gene

Interacting Proteins for CYP4Z1 Gene

Gene Ontology (GO) - Biological Process for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

No data available for SIGNOR curated interactions for CYP4Z1 Gene

Drugs & Compounds for CYP4Z1 Gene

(18) Drugs for CYP4Z1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 512
Codeine Approved, Illicit Pharma Full agonist, Agonist 77
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1318
Estrone Approved Pharma Agonist Estrogenic hormone 21
Formaldehyde Approved, Vet_approved Pharma 93

(23) Additional Compounds for CYP4Z1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP4Z1: view

Transcripts for CYP4Z1 Gene

mRNA/cDNA for CYP4Z1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4Z1 Gene

Cytochrome P450, family 4, subfamily Z, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4Z1 Gene

No ASD Table

Relevant External Links for CYP4Z1 Gene

GeneLoc Exon Structure for
CYP4Z1
ECgene alternative splicing isoforms for
CYP4Z1

Expression for CYP4Z1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4Z1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4Z1 Gene

This gene is overexpressed in Breast - Mammary Tissue (x9.6) and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for CYP4Z1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4Z1 Gene



Protein tissue co-expression partners for CYP4Z1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP4Z1 Gene:

CYP4Z1

SOURCE GeneReport for Unigene cluster for CYP4Z1 Gene:

Hs.176588

mRNA Expression by UniProt/SwissProt for CYP4Z1 Gene:

Q86W10-CP4Z1_HUMAN
Tissue specificity: Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.
genes like me logo Genes that share expression patterns with CYP4Z1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4Z1 Gene

Orthologs for CYP4Z1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP4Z1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC456834 34
  • 97.25 (n)
CYP4Z1 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4a12b 35
  • 49 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
Species where no ortholog for CYP4Z1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4Z1 Gene

ENSEMBL:
Gene Tree for CYP4Z1 (if available)
TreeFam:
Gene Tree for CYP4Z1 (if available)

Paralogs for CYP4Z1 Gene

(14) SIMAP similar genes for CYP4Z1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CYP4Z1 Gene

genes like me logo Genes that share paralogs with CYP4Z1: view

Variants for CYP4Z1 Gene

Sequence variations from dbSNP and Humsavar for CYP4Z1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000007975 -- 47,074,480(+) GATGT(G/T)ATTTC intron-variant
rs1000386369 -- 47,079,131(+) CAAAA(C/T)AAACA intron-variant
rs1000443346 -- 47,078,671(+) AAAGA(A/G)AAAAA intron-variant
rs1000511617 -- 47,110,035(+) AGATA(A/C)TGTGC intron-variant
rs1000700602 -- 47,093,669(+) GAGGG(C/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4Z1 Gene

Variant ID Type Subtype PubMed ID
dgv32e212 CNV gain 25503493
dgv80n106 CNV duplication 24896259
esv24824 CNV loss 19812545
esv2763300 CNV gain 21179565
esv3585951 CNV gain 21293372
nsv1009338 CNV gain 25217958
nsv1077760 OTHER inversion 25765185
nsv945929 CNV duplication 23825009

Variation tolerance for CYP4Z1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4Z1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4Z1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Disorders for CYP4Z1 Gene

Relevant External Links for CYP4Z1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4Z1

No disorders were found for CYP4Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4Z1 Gene

Publications for CYP4Z1 Gene

  1. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PMID: 15059886) Rieger M.A. … Weigle B. (Cancer Res. 2004) 2 3 4 22 64
  2. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 3 22 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer. (PMID: 26980484) Zheng L. … Xi T. (Mol. Cell. Endocrinol. 2016) 3 64
  5. The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1. (PMID: 25701119) Zheng L. … Xi T. (Breast Cancer Res. Treat. 2015) 3 64

Products for CYP4Z1 Gene

Sources for CYP4Z1 Gene

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