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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP4Z1 Gene

protein-coding   GIFtS: 47
GCID: GC01P047533

Cytochrome P450, Family 4, Subfamily Z, Polypeptide 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 4, Subfamily Z, Polypeptide 11 2
CYPIVZ12 3
CYP4A202
Cytochrome P450 4Z12
EC 1.14.14.13

External Ids:    HGNC: 205831   Entrez Gene: 1999742   Ensembl: ENSG000001861607   UniProtKB: Q86W103   

Export aliases for CYP4Z1 gene to outside databases

Previous GC identifers: GC01P046923 GC01P046903 GC01P046902 GC01P047245 GC01P047305 GC01P045649


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP4Z1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CYP4Z1 Gene: 
CYP4Z1 (cytochrome P450, family 4, subfamily Z, polypeptide 1) is a protein-coding gene. Diseases associated with CYP4Z1 include cytochrome p450, and tuberculosis, and among its related super-pathways are Cytochrome P450 - arranged by substrate type and Biological oxidations. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

Gene Wiki entry for CYP4Z1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP4Z1 gene promoter:
         LHX3b/Lhx3b   AML1a   Pax-5   Nkx2-2   Gfi-1   RORalpha1   PPAR-alpha   LHX3a/Lhx3a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4Z1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP4Z1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4Z1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4Z1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4Z1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047533:  view genomic region     (about GC identifiers)

Start:
47,533,160 bp from pter      End:
47,583,992 bp from pter
Size:
50,833 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10 (See protein sequence)
Recommended Name: Cytochrome P450 4Z1  
Size: 505 amino acids; 59086 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane;
Single-pass type II membrane protein
Secondary accessions: Q5VVE4

Explore the universe of human proteins at neXtProt for CYP4Z1: NX_Q86W10

Explore proteomics data for CYP4Z1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86W10

  • CYP4Z1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP4Z1 Protein Expression
    REFSEQ proteins: NP_835235.1  
    ENSEMBL proteins: 
     ENSP00000334246  

    Human Recombinant Protein Products for CYP4Z1: 
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    Cloud-Clone Corp. Proteins for CYP4Z1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    CYP4Z1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4Z1 
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q86W10

    ProtoNet protein and cluster: Q86W10

    UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10
    Similarity: Belongs to the cytochrome P450 family


    CYP4Z1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4Z1_HUMAN, Q86W10
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Enzyme Number (IUBMB): EC 1.14.14.11

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
    GO:0070330aromatase activity IEA--
         
    CYP4Z1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP4Z1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP4Z1 
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    miRNA
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    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4Z1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP4Z1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    cytochrome P4500.75
    2Biological oxidations
    metapathway biotransformation0.41


    2 BioSystems Pathways for CYP4Z1
        cytochrome P450
    metapathway biotransformation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4Z1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    CYP4Z1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP4Z1 (CP4Z1)

    10/49 HMDB Compounds for CYP4Z1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Search CenterWatch for drugs/clinical trials and news about CYP4Z1 / CP4Z1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP4Z1 gene: 
    NM_178134.2  

    Unigene Cluster for CYP4Z1:

    Cytochrome P450, family 4, subfamily Z, polypeptide 1
    Hs.176588  [show with all ESTs]
    Unigene Representative Sequence: AY358631
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334194(uc001cqu.1) ENST00000471598
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CYP4Z1
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP4Z1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4Z1
    Sirion Biotech Customized lentivirus for stable overexpression of CYP4Z1 
                         Customized lentivirus expression plasmids for stable overexpression of CYP4Z1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYP4Z1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP4Z1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYP4Z1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4Z1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4Z1

    Additional mRNA sequence: 

    AK292175.1 AY262056.1 AY358631.1 

    2 DOTS entries:

    DT.100742965  DT.106617 

    22 AceView cDNA sequences:

    AY358631 NM_178134 AI668594 BG201072 BG210988 AY262056 H21976 BG218514 
    BG193485 AV700083 AI733538 BX094680 AV689946 BG219391 AI668602 BG212152 
    H25577 AW472756 BG204180 AI820775 H25624 BG192933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP4Z1 expression in normal human tissues (normalized intensities)      CYP4Z1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGCTTTAT
    CYP4Z1 Expression
    About this image


    CYP4Z1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Breast (NULL)    fully expand to see all 3 entries
             MAMMARY GLAND   
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose

    See CYP4Z1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP4Z1

    SOURCE GeneReport for Unigene cluster: Hs.176588

    UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10
    Tissue specificity: Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal
    expression is found in all other tested tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4Z1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4Z1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CYP4B16
    --
    Uncharacterized protein
    49(a)
    49(a)
    possible ortholog
    possible ortholog
    8(20783471-20790800)
    8(20771032-20780775)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    --
    49(a)
    48(a)
    (see all 6)
    many ↔ many
    possible ortholog
    (see all 6)
    GL343249.1(1880734-1908444)
    GL343249.1(1998735-2033839)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB022671.12   -- 73.56(n)    AB022671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4t86
    cytochrome P450, family 4, subfamily T, polypeptid...
    45(a)
    1 → many
    16(5534736-5584736)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BAS11 PHYB activation tagged suppressor 1 protein 44.55(n)
    33.65(a)
      817212  NM_128228.3  NP_180239.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06004001 hypothetical protein 42.5(n)
    30.17(a)
      4341450  NM_001064535.1  NP_001058000.1 
            Species with no ortholog for CYP4Z1

    ENSEMBL Gene Tree for CYP4Z1 (if available)
    TreeFam Gene Tree for CYP4Z1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP4Z1 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4F122  CYP4X12  
    14 SIMAP similar genes for CYP4Z1 using alignment to 1 protein entry:     CP4Z1_HUMAN:
    CYP4Z2P    CYP4X1    CYP4A11    CYP4B1    CYP4F12    CYP4F22
    CYP4F8    CYP4F11    CYP4F2    DKFZp761K058    CYP4F3    CYP4A22
    CYP3A43/CYP3A4    CYP4V2

    CYP4Z1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP4Z1
    PGOHUM00000244006


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1092 SNPs in CYP4Z1 are shown (see all 1092)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012299391,2
    --45653614(+) TGGAT-/GATA  
            
    GATAG
    1 -- int10--------
    rs22658941,2
    C--45669990(-) ACTACC/TATCAG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs604997421,2
    C--45693844(+) ATAAC-/AAAC  
            
    CTACT
    1 -- int11Minor allele frequency- AAAC:0.00NA 2
    rs1117995881,2
    C,F--47531230(+) TAGCAC/TCAAAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs127574891,2
    H--47531446(+) gatgaA/Gccatt 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs127575011,2
    H--47531462(+) gattaA/Tcgaag 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs710500821,2
    C--47542517(-) CATTC-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs133740821,2
    C,F,H--47550180(+) TTCATT/GTTGTA 1 -- int16Minor allele frequency- G:0.06NS EA NA WA 540
    rs43472511,2
    C,F,A--47551511(+) cccacC/Acccct 1 -- int1 trp32Minor allele frequency- A:0.25NA 4
    rs597551991,2
    C,F--47556189(+) TCTACG/AAATAA 1 -- int12Minor allele frequency- A:0.10WA 120

    HapMap Linkage Disequilibrium report for CYP4Z1 (47533160 - 47583992 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP4Z1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv24824CNV Loss19812545
    dgv221n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4Z1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4Z1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for CYP4Z1:    About MalaCards
    cytochrome p450    tuberculosis    lung cancer    breast cancer


    CYP4Z1 for disorders           About GeneDecksing


    Export disorders for CYP4Z1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP4Z1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CYP4Z1)
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    world of online information

    1. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PubMed id 15059886)1, 2, 3, 9 Rieger M.A.... Weigle B. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PubMed id 15797250)1, 9 Savas U....Johnson E.F. (2005)
    4. Increased expression of CYP4Z1 promotes tumor angiogen esis and growth in human breast cancer. (PubMed id 22841774)1 Yu W....Yang J. (2012)
    5. Identification of genes associated with non-small-cel l lung cancer promotion and progression. (PubMed id 19473719)1 Bankovic J....Tanic N. (2010)
    6. Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid. (PubMed id 19090726)1 ZAPllner A....Bureik M. (2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
    10. The cytochrome P450 4 (CYP4) family. (PubMed id 9068972)1 Simpson A.E. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199974 HGNC: 20583 AceView: CYP4Z1 Ensembl:ENSG00000186160 euGenes: HUgn199974
    ECgene: CYP4Z1 H-InvDB: CYP4Z1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP4Z1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP4Z1 gene:
    Search GeneIP for patents involving CYP4Z1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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