Aliases for CYP4Z1 Gene
Aliases for CYP4Z1 Gene
External Ids for CYP4Z1 Gene
- HGNC: 20583
- Entrez Gene: 199974
- Ensembl: ENSG00000186160
- UniProtKB: Q86W10
Previous GeneCards Identifiers for CYP4Z1 Gene
- GC01P046923
- GC01P046903
- GC01P046902
- GC01P047245
- GC01P047305
- GC01P047533
- GC01P045649
Summaries for CYP4Z1 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP4Z1 Gene
CYP4Z1 (Cytochrome P450 Family 4 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4X1.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4Z1 Gene
Genomics for CYP4Z1 Gene
Regulatory Elements for CYP4Z1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G047030 | 1 | Ensembl ENCODE | 9.1 | -36.4 | -36362 | 1.4 | NFIB ZNF76 FEZF1 ZNF7 ZNF366 ZBTB48 FOS ZNF600 PRDM10 ZNF10 | POMGNT1 CYP4Z1 CYP4A22 CYP4X1 GC01M047004 |
| GH01G047107 | 0.8 | Ensembl ENCODE | 10.7 | +40.7 | 40677 | 2.0 | CEBPG HNF4A FOS ZIC2 PRDM1 | CYP4A22 CYP4A22-AS1 LINC00853 CYP4Z1 GC01M047099 LOC100533626 |
| GH01G046519 | 1.6 | FANTOM5 Ensembl ENCODE | 4.9 | -545.8 | -545841 | 3.6 | HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS | EFCAB14-AS1 DMBX1 IPP KNCN EFCAB14 TEX38 ATPAF1 NSUN4 MKNK1 CYP4Z1 |
| GH01G047649 | 1.1 | Ensembl ENCODE | 5.2 | +583.9 | 583911 | 3.3 | FOXA2 ZNF133 ZSCAN4 KLF17 BMI1 FOS EGR2 CEBPB NR2F2 SREBF1 | CYP4Z1 GC01P047675 GC01P047570 |
| GH01G047707 | 0.6 | dbSUPER | 4.2 | +640.5 | 640523 | 1.1 | ZFHX2 SMARCA4 EGR1 SUZ12 ZNF133 CBX2 EZH2 | LINC01738 CYP4Z1 GC01P047709 PIR52707 |
- Transcription factor binding sites by QIAGEN in the CYP4Z1 gene promoter:
Regulatory Element Products
Genomic Location for CYP4Z1 Gene
- Chromosome:
- 1
- Start:
- 47,067,448 bp from pter
- End:
- 47,118,320 bp from pter
- Size:
- 50,873 bases
- Orientation:
- Plus strand
Genomic View for CYP4Z1 Gene
- Cytogenetic band:
-
- 1p33 by Ensembl
- 1p33 by Entrez Gene
- 1p33 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP4Z1 Gene
Proteins for CYP4Z1 Gene
-
Protein details for CYP4Z1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86W10-CP4Z1_HUMAN
- Recommended name:
- Cytochrome P450 4Z1
- Protein Accession:
- Q86W10
- Q5VVE4
Protein attributes for CYP4Z1 Gene
- Size:
- 505 amino acids
- Molecular mass:
- 59086 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP4Z1 Gene
Post-translational modifications for CYP4Z1 Gene
Other Protein References for CYP4Z1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYP4Z1
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-
Abcam antibodies for CYP4Z1
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- antibodies-online Antibodies for CYP4Z1: See all 22
- GeneTex CYP4Z1 antibody for CYP4Z1
Protein Products
-
OriGene Purified Proteins for CYP4Z1
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-
Abcam proteins for CYP4Z1
Assay Products
- antibodies-online Kits for CYP4Z1: See all 7
No data available for DME Specific Peptides for CYP4Z1 Gene
Domains & Families for CYP4Z1 Gene
Gene Families for CYP4Z1 Gene
- HGNC:
- IUPHAR :
Protein Domains for CYP4Z1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP4Z1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86W10- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP4Z1 Gene
Molecular function for CYP4Z1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
Enzyme Numbers (IUBMB) for CYP4Z1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
| GO:0020037 | heme binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CYP4Z1 Gene
- GenomeRNAi human phenotypes for CYP4Z1:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
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miRNA Products
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Inhibitory RNA Products
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- VectorBuilder custom plasmid, inducible vectors for CYP4Z1
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CYP4Z1
-
ViGene Biosciences adenoviral particle packaged cDNA for CYP4Z1 gene
-
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-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4Z1 Gene
Localization for CYP4Z1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP4Z1 Gene
- Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0031090 | organelle membrane | IEA | -- |
Pathways & Interactions for CYP4Z1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type | ||
Pathways by source for CYP4Z1 Gene
2 BioSystems pathways for CYP4Z1 Gene
Interacting Proteins for CYP4Z1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for CYP4Z1 Gene
Drugs & Compounds for CYP4Z1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Citalopram | Approved | Pharma | 512 | |||
| Codeine | Approved, Illicit | Pharma | Full agonist, Agonist | 77 | ||
| Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1318 | ||
| Estrone | Approved | Pharma | Agonist | Estrogenic hormone | 21 | |
| Formaldehyde | Approved, Vet_approved | Pharma | 93 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 11,12,15-THETA |
|
|
||||
| 11,12-Epoxyeicosatrienoic acid |
|
81276-02-0 |
|
|||
| 11,14,15-THETA |
|
|
||||
| 11H-14,15-EETA |
|
219535-29-2 |
|
|||
| 12,13-EpOME |
|
|
Transcripts for CYP4Z1 Gene
mRNA/cDNA for CYP4Z1 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYP4Z1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP4Z1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP4Z1
- GenScript: Design CRISPR guide RNA sequences for CYP4Z1
miRNA Products
- Search ViGene Biosciences for CYP4Z1
Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for CYP4Z1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYP4Z1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP4Z1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CYP4Z1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Breast (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for CYP4Z1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4Z1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CYP4Z1 Gene:
CYP4Z1SOURCE GeneReport for Unigene cluster for CYP4Z1 Gene:
Hs.176588mRNA Expression by UniProt/SwissProt for CYP4Z1 Gene:
Q86W10-CP4Z1_HUMANPrimer Products
-
OriGene qPCR primer pairs and template standards for CYP4Z1
-
OriGene qPCR primer pairs for CYP4Z1
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4Z1 Gene
Orthologs for CYP4Z1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC456834 34 |
|
||
| CYP4Z1 35 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Cyp4a12b 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for CYP4Z1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CYP4Z1 Gene
Paralogs for CYP4Z1 Gene
(14) SIMAP similar genes for CYP4Z1 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for CYP4Z1 Gene
Variants for CYP4Z1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007975 | -- | 47,074,480(+) | GATGT(G/T)ATTTC | intron-variant | |
| rs1000386369 | -- | 47,079,131(+) | CAAAA(C/T)AAACA | intron-variant | |
| rs1000443346 | -- | 47,078,671(+) | AAAGA(A/G)AAAAA | intron-variant | |
| rs1000511617 | -- | 47,110,035(+) | AGATA(A/C)TGTGC | intron-variant | |
| rs1000700602 | -- | 47,093,669(+) | GAGGG(C/G)CTATT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv32e212 | CNV | gain | 25503493 |
| dgv80n106 | CNV | duplication | 24896259 |
| esv24824 | CNV | loss | 19812545 |
| esv2763300 | CNV | gain | 21179565 |
| esv3585951 | CNV | gain | 21293372 |
| nsv1009338 | CNV | gain | 25217958 |
| nsv1077760 | OTHER | inversion | 25765185 |
| nsv945929 | CNV | duplication | 23825009 |
Relevant External Links for CYP4Z1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CYP4Z1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4Z1 Gene
Disorders for CYP4Z1 Gene
Relevant External Links for CYP4Z1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CYP4Z1
No disorders were found for CYP4Z1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4Z1 Gene
Publications for CYP4Z1 Gene
- Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PMID: 15059886) Rieger M.A. … Weigle B. (Cancer Res. 2004) 2 3 4 22 64
- Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 3 22 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
- Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer. (PMID: 26980484) Zheng L. … Xi T. (Mol. Cell. Endocrinol. 2016) 3 64
- The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1. (PMID: 25701119) Zheng L. … Xi T. (Breast Cancer Res. Treat. 2015) 3 64
Products for CYP4Z1 Gene
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- VectorBuilder custom plasmid, inducible vectors for CYP4Z1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP4Z1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CYP4Z1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (136) ViGene Biosciences
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- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer



