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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP4X1 Gene

protein-coding   GIFtS: 50
GCID: GC01P047489

cytochrome P450, family 4, subfamily X, polypeptide 1
 Explore 22 diseases affiliated with
CYP4X1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYP4X1    

Aliases
for CYP4X1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome P450, Family 4, Subfamily X, Polypeptide 11 2
CYPIVX12 3
MGC400511
Cytochrome P450 4X12
EC 1.14.14.13

External Ids:    HGNC: 202441   Entrez Gene: 2602932   Ensembl: ENSG000001863777   OMIM: 6149995   UniProtKB: Q8N1183   

Export aliases for CYP4X1 gene to outside databases

Previous GC identifers: GC00U991261 GC01U900708 GC01P046859 GC01P047201 GC01P047261 GC01P045605


Summaries
for CYP4X1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP4X1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in
neurovascular function in the brain. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CYP4X1


Genomic Views
for CYP4X1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP4X1 gene promoter:
         NCX/Ncx   FOXL1   AREB6   RORalpha1   HEN1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP4X1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP4X1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4X1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33|1   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4X1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4X1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047489:  view genomic region     (about GC identifiers)

Start:
 47,427,036 bp from pter      End:
 47,516,423 bp from pter
Size:
 89,388 bases      Orientation:
 plus strand

Proteins
for CYP4X1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118 (See protein sequence)
Recommended Name: Cytochrome P450 4X1  
Size: 509 amino acids; 58875 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane (By similarity); Single-pass membrane protein (Potential).
Microsome membrane (By similarity)
Secondary accessions: G3V1U1 Q5VVE5 Q6ZN67 Q8NAZ3
Alternative splicing: 3 isoforms:  Q8N118-1   Q8N118-2   Q8N118-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP4X1: NX_Q8N118

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N118

    • CYP4X1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_828847.1  
    ENSEMBL proteins: 
     ENSP00000360968   ENSP00000445965  

    Human Recombinant Protein Products: 
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    Novus Biologicals CYP4X1 Protein
    Novus Biologicals CYP4X1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CYP4X1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--


    CYP4X1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CYP4X1

    Protein Domains /
    Families
    for CYP4X1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYP4X1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q8N118

    ProtoNet protein and cluster: Q8N118

    1 Blocks protein family: IPB002401 E-class P450 group I signature

    UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Similarity: Belongs to the cytochrome P450 family


    Function
    for CYP4X1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

    Enzyme Number (IUBMB): EC 1.14.14.11

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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CYP4X1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--


    CYP4X1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cyp4x1tm1Lex for CYP4X1
         1 MGI phenotypic allele for Cyp4x1 (no phenotypes)

    CYP4X1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CYP4X1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1superpathway of melatonin degradation
    		superpathway of melatonin degradation1.00
    		melatonin degradation I0.85
    2nicotine degradation III
    		nicotine degradation III1.00
    		nicotine degradation IV0.62
    3acetone degradation I (to methylglyoxal)
    		acetone degradation I (to methylglyoxal)1.00
    		bupropion degradation0.44
    4Cytochrome P450 - arranged by substrate type
    		cytochrome P4500.73
    5Biological oxidations
    		metapathway biotransformation0.41


    5/8 BioSystems Pathways for CYP4X1 (see all 8) 
        cytochrome P450
    nicotine degradation IV
    nicotine degradation III
    acetone degradation I (to methylglyoxal)
    melatonin degradation I


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4X1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for CYP4X1 (ENSP000003609684) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1B1ENSP000002859304STRING: ENSP00000285930
    AOX1ENSP000003638324STRING: ENSP00000363832
    CYP2E1ENSP000002529454STRING: ENSP00000252945
    CYP2S1ENSP000003080324STRING: ENSP00000308032
    CYP2U1ENSP000003332124STRING: ENSP00000333212
    About this table

    Drugs & Compounds
    for CYP4X1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP4X1

    10/49 HMDB Compounds for CYP4X1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    Search CenterWatch for drugs/clinical trials and news about CYP4X1 / CP4X1 

    Transcripts
    for CYP4X1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYP4X1 gene: 
    NM_178033.1  

    Unigene Cluster for CYP4X1:

    Cytochrome P450, family 4, subfamily X, polypeptide 1
    Hs.439760  [show with all ESTs]
    Unigene Representative Sequence: NM_178033
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371901(uc001cqs.3 uc001cqt.3) ENST00000466294 ENST00000538609(uc001cqr.3)


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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK091806.1 AK098065.1 AK131355.1 AM040940.1 AY358537.1 BC028102.1 

    8 DOTS entries:

    DT.210786  DT.102821989  DT.40110390  DT.99931108  DT.121412485  DT.121412526  DT.40281971  DT.95134706 

    24/64 AceView cDNA sequences (see all 64):

    AI923200 AI436648 AK091806 BQ022205 AI697332 AA652746 BU684682 AK131355 
    BF445825 CA438689 AW264444 CD721887 AY358537 NM_178033 BQ023919 AK098065 
    AX747195 BC028102 AL138223 AI696732 BQ003058 BE671969 AA863360 BI916692 

    GeneLoc Exon Structure


    Expression
    for CYP4X1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP4X1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGACCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CYP4X1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See CYP4X1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP4X1

    SOURCE GeneReport for Unigene cluster: Hs.439760

    UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Tissue specificity: Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the
    heart, very high level levels in aorta, but very levels in other heart regions

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    In Situ
    Assay Products:     
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    Orthologs
    for CYP4X1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4X1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NNP0_CHICK6
    		 Uncharacterized protein
    		 47(a)
    		 1 → many
    		 8(22606274-22613175)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 6)    		 --
    		 50(a)
    50(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 GL343249.1(2000367-2033412)
    GL343249.1(1835205-1850928)
    zebrafish
    (Danio rerio)    		 Actinopterygii cyp4t86
    		 cytochrome P450, family 4, subfamily T, polypeptid...
    		 46(a)
    		 1 → many
    		 16(5534736-5584736)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYP709B16
    CYP72A76
    (see all 22)    		 cytochrome P450, family 709, subfamily B, polypept...
    cytochrome P450, family 72, subfamily A, polypepti...
    (see all 22)    		 21(a)
    20(a)
    (see all 22)    		 possible ortholog
    possible ortholog
    (see all 22)    		 2(19292049-19294260)
    3(4912466-4914652)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 42)    		 cytochrome P450 72A1, putative, expressed
    (see all 42)    		 24(a)
    24(a)
    (see all 42)    		 possible ortholog
    possible ortholog
    (see all 42)    		 7(13381838-13383137)
    3(14558010-14560532)


    ENSEMBL Gene Tree for CYP4X1 (if available)
    TreeFam Gene Tree for CYP4X1 (if available) 

    Paralogs
    for CYP4X1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP4X1 gene
    CYP4F222  CYP4F32  CYP4F22  CYP4F112  CYP46A12  ENSG000002256072  CYP4B12  CYP3A52  
    TBXAS12  CYP3A432  CYP3A42  CYP3A72  CYP4V22  CYP4A222  CYP4A112  CYP4F122  
    CYP4Z12  
    13 SIMAP similar genes for CYP4X1 using alignment to 1 protein entry:     CP4X1_HUMAN:
    CYP4Z1    CYP4Z2P    CYP4A11    CYP4B1    CYP4F12    CYP4F3
    CYP4F11    CYP4F8    DKFZp761K058    CYP4F2    CYP4F22    CYP4A22
    CYP4V2

    CYP4X1 for paralogs           About GeneDecksing



    Genomic Variants
    for CYP4X1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/497 NCBI SNPs in CYP4X1 are shown (see all 497)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs121325371,2
    		C,H,--45603498(+) TGGAAC/TGNNNN 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 536
    rs773988341,2
    		C,F,--45603547(+) GCATAG/CAACTG 1 -- us2k11Minor allele frequency- C:0.05EA 120
    rs728903941,2
    		C,F,--45603606(+) TAGGTG/AAGCCA 1 -- us2k13Minor allele frequency- A:0.10WA CSA 122
    rs740738031,2
    		C,--45603787(+) CCATGC/TGATCA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs171029501,2
    		C,F,H,--45603925(+) TCAAAT/CAACAA 1 -- us2k120Minor allele frequency- C:0.07NA NS EA WA 2482
    rs740738041,2
    		C,--45604912(+) TTAATA/GAAGTT 1 -- us2k14Minor allele frequency- G:0.09WA NA EA 360
    rs20554981,2
    		C,F,O,H,--45605122(-) GTTCCG/AGTAAA 1 -- us2k1 tfbs321Minor allele frequency- A:0.07NS EA NA WA 2484
    rs38139991,2
    		C,--45605442(+) TCCCCA/GGGCCT 1 -- ut51 ese30--------
    rs38140001,2
    		H--45605463(+) TCCCAC/GTGCCT 1 -- ut51 ese34Minor allele frequency- G:0.00NS EA 418
    rs115820761,2
    		H--45606412(+) ACTAAG/CATTAC 1 -- int14Minor allele frequency- C:0.00NS EA 420

    HapMap Linkage Disequilibrium report for CYP4X1 (47427036 - 47516423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYP4X1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4X1
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    Disorders / Diseases
    for CYP4X1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYP4X1 for disorders           About GeneDecksing

    OMIM gene information: 614999    OMIM disorders: --

    20/22 diseases for CYP4X1 (see all 22):    About MalaCards
    antley-bixler syndrome    human immunodeficiency virus infectious disease    toxic encephalopathy    adrenal hyperplasia
    fascioliasis    porphyria    aspergillosis    constipation
    candidiasis    cholesterol    neurodegenerative disease    skin disease
    cholestasis    brain disease    hypercholesterolemia    diarrhea
    hepatocellular carcinoma    tuberculosis    immunodeficiency    malaria


    Export disorders for CYP4X1 gene to outside databases

    Publications
    for CYP4X1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP4X1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CYP4X1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (PubMed id 12176035)1, 3 Bylund J....Harder D.R. (2002)
    5. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PubMed id 15797250)1, 9 Savas U....Johnson E.F. (2005)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain. (PubMed id 16478468)2 Al-Anizy M.... Bell D.R. (2006)
    9. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CYP4X1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYP4X1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 260293 HGNC: 20244 AceView: CYP4X1 Ensembl:ENSG00000186377 euGenes: HUgn260293
    ECgene: CYP4X1 H-InvDB: CYP4X1

    Other Databases showing CYP4X1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP4X1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP4X1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CYP4X1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP4X1 gene:
    Search GeneIP for patents involving CYP4X1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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