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Aliases for CYP4X1 Gene

Aliases for CYP4X1 Gene

  • Cytochrome P450, Family 4, Subfamily X, Polypeptide 1 2 3
  • CYPIVX1 3 4 6
  • Cytochrome P450 4X1 3
  • EC 4

External Ids for CYP4X1 Gene

Previous GeneCards Identifiers for CYP4X1 Gene

  • GC00U991261
  • GC01U900708
  • GC01P046859
  • GC01P047201
  • GC01P047261
  • GC01P047489
  • GC01P045605

Summaries for CYP4X1 Gene

Entrez Gene Summary for CYP4X1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4X1 Gene

CYP4X1 (Cytochrome P450, Family 4, Subfamily X, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Biological oxidations. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

Gene Wiki entry for CYP4X1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4X1 Gene

Genomics for CYP4X1 Gene

Regulatory Elements for CYP4X1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP4X1 Gene

47,023,568 bp from pter
47,050,751 bp from pter
27,184 bases
Plus strand

Genomic View for CYP4X1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4X1 Gene

Proteins for CYP4X1 Gene

  • Protein details for CYP4X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 4X1
    Protein Accession:
    Secondary Accessions:
    • G3V1U1
    • Q5VVE5
    • Q6ZN67
    • Q8NAZ3

    Protein attributes for CYP4X1 Gene

    509 amino acids
    Molecular mass:
    58875 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4X1 Gene


neXtProt entry for CYP4X1 Gene

Proteomics data for CYP4X1 Gene at MOPED

Post-translational modifications for CYP4X1 Gene

  • Ubiquitination at Lys75 and Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP4X1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CYP4X1 Gene

Domains for CYP4X1 Gene

Gene Families for CYP4X1 Gene

  • CYP :Cytochrome P450s

Protein Domains for CYP4X1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N118
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4X1: view

Function for CYP4X1 Gene

Molecular function for CYP4X1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Numbers (IUBMB) for CYP4X1 Gene

Gene Ontology (GO) - Molecular Function for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4X1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP4X1 Gene

Localization for CYP4X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4X1 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.

Subcellular locations from

Jensen Localization Image for CYP4X1 Gene COMPARTMENTS Subcellular localization image for CYP4X1 gene
Compartment Confidence
endoplasmic reticulum 2
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

Pathways for CYP4X1 Gene

genes like me logo Genes that share pathways with CYP4X1: view

Pathways by source for CYP4X1 Gene

Interacting Proteins for CYP4X1 Gene

Gene Ontology (GO) - Biological Process for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

Compounds for CYP4X1 Gene

(49) HMDB Compounds for CYP4X1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
genes like me logo Genes that share compounds with CYP4X1: view

Transcripts for CYP4X1 Gene

mRNA/cDNA for CYP4X1 Gene

Unigene Clusters for CYP4X1 Gene

Cytochrome P450, family 4, subfamily X, polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4X1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4X1 Gene

No ASD Table

Relevant External Links for CYP4X1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP4X1 Gene

mRNA expression in normal human tissues for CYP4X1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CYP4X1 Gene

This gene is overexpressed in Breast (38.5), Heart (9.0), and Fetal Brain (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP4X1 Gene

SOURCE GeneReport for Unigene cluster for CYP4X1 Gene Hs.439760

mRNA Expression by UniProt/SwissProt for CYP4X1 Gene

Tissue specificity: Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.
genes like me logo Genes that share expressions with CYP4X1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for CYP4X1 Gene

Orthologs for CYP4X1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4X1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100847677 35
  • 79.37 (n)
  • 67.66 (a)
CYP4X1 36
  • 66 (a)
(Canis familiaris)
Mammalia CYP4X1 35
  • 84.32 (n)
  • 74.51 (a)
CYP4X1 36
  • 74 (a)
(Mus musculus)
Mammalia Cyp4x1 35
  • 81.07 (n)
  • 71.2 (a)
Cyp4x1 16
Cyp4x1 36
  • 71 (a)
(Pan troglodytes)
Mammalia LOC456833 35
  • 99.61 (n)
  • 99.61 (a)
CYP4X1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cyp4x1 35
  • 80.47 (n)
  • 70.02 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
-- 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
-- 36
  • 45 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
-- 36
  • 49 (a)
-- 36
  • 47 (a)
-- 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP714A1 35
  • 43.66 (n)
  • 30.73 (a)
(Oryza sativa)
Liliopsida Os11g0119700 35
  • 42.98 (n)
  • 30.95 (a)
Species with no ortholog for CYP4X1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4X1 Gene

Gene Tree for CYP4X1 (if available)
Gene Tree for CYP4X1 (if available)

Paralogs for CYP4X1 Gene

Selected SIMAP similar genes for CYP4X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP4X1: view

Variants for CYP4X1 Gene

Sequence variations from dbSNP and Humsavar for CYP4X1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1021827 -- 47,021,913(-) TGGTC(C/T)GGTCC upstream-variant-2KB
rs1021828 -- 47,021,896(-) TCTTC(A/G)TGAGA upstream-variant-2KB
rs1039468 -- 47,040,680(+) ATATA(C/T)ATGTA intron-variant
rs1039469 -- 47,021,717(-) TGCCC(C/T)TGTCC upstream-variant-2KB
rs1117514 -- 47,041,169(+) tacca(C/T)gtttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4X1 Gene

Variant ID Type Subtype PubMed ID
dgv220n71 CNV Gain 21882294
nsv870674 CNV Gain 21882294
nsv871717 CNV Gain 21882294
nsv461428 CNV Gain 19166990
nsv871080 CNV Gain 21882294

Relevant External Links for CYP4X1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4X1 Gene

Disorders for CYP4X1 Gene

No disorders were found for CYP4X1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CYP4X1 Gene

Publications for CYP4X1 Gene

  1. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 3 23
  2. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (PMID: 12176035) Bylund J. … Harder D.R. (Biochem. Biophys. Res. Commun. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CYP4X1 Gene

Sources for CYP4X1 Gene

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