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CYP4X1 Gene

protein-coding   GIFtS: 54
GCID: GC01P047489

Cytochrome P450, Family 4, Subfamily X, Polypeptide 1

  Search for CYP4X1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 4, Subfamily X, Polypeptide 11 2
CYPIVX12 3 5
Cytochrome P450 4X12
EC 1.14.14.13

External Ids:    HGNC: 202441   Entrez Gene: 2602932   Ensembl: ENSG000001863777   OMIM: 6149995   UniProtKB: Q8N1183   

Export aliases for CYP4X1 gene to outside databases

Previous GC identifers: GC00U991261 GC01U900708 GC01P046859 GC01P047201 GC01P047261 GC01P045605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4X1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in
neurovascular function in the brain. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4X1 Gene:
CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

Gene Wiki entry for CYP4X1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4X1 gene promoter:
         NCX/Ncx   FOXL1   AREB6   RORalpha1   HEN1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP4X1 promoter sequence
   Search Chromatin IP Primers for CYP4X1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4X1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33|1   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4X1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4X1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047489:  view genomic region     (about GC identifiers)

Start:
47,427,036 bp from pter      End:
47,516,423 bp from pter
Size:
89,388 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118 (See protein sequence)
Recommended Name: Cytochrome P450 4X1  
Size: 509 amino acids; 58875 Da
Cofactor: Heme group (By similarity)
Secondary accessions: G3V1U1 Q5VVE5 Q6ZN67 Q8NAZ3
Alternative splicing: 3 isoforms:  Q8N118-1   Q8N118-2   Q8N118-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP4X1: NX_Q8N118

Explore proteomics data for CYP4X1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys75, Lys132
  • Modification sites at PhosphoSitePlus

  • See CYP4X1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_828847.1  
    ENSEMBL proteins: 
     ENSP00000360968   ENSP00000445965  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4X1
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q8N118

    ProtoNet protein and cluster: Q8N118

    1 Blocks protein domain: IPB002401 E-class P450 group I signature

    UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP4X1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4X1_HUMAN, Q8N118
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Enzyme Number (IUBMB): EC 1.14.14.11

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
    GO:0070330aromatase activity IEA--
         
    Find genes that share ontologies with CYP4X1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cyp4x1 (no phenotypes)

    Find genes that share phenotypes with CYP4X1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cyp4x1tm1Lex for CYP4X1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4X1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4X1_HUMAN, Q8N118: Endoplasmic reticulum membrane (By similarity); Single-pass membrane protein (Potential).
    Microsome membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    golgi apparatus2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CYP4X1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4X1 About    
    See pathways by source

    SuperPathContained pathways About
    1acetone degradation I (to methylglyoxal)
    bupropion degradation0.44
    nicotine degradation IV0.33
    acetone degradation I (to methylglyoxal)0.44
    nicotine degradation III0.00
    2tryptophan utilization II
    tryptophan utilization I0.71
    melatonin degradation I0.00
    superpathway of melatonin degradation0.00
    3Cytochrome P450 - arranged by substrate type
    cytochrome P4500.74
    4Biological oxidations
    metapathway biotransformation0.42
    5Circadian entrainment
    Serotonergic synapse0.33


    Find genes that share SuperPaths with CYP4X1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for CYP4X1 (see all 9)
        cytochrome P450
    nicotine degradation IV
    nicotine degradation III
    bupropion degradation
    melatonin degradation I



    1 Kegg Pathway  (Kegg details for CYP4X1):
        Serotonergic synapse

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYP4X1
    Interactions:

        Search GeneGlobe Interaction Network for CYP4X1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP4X1 (ENSP000003609684) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1B1ENSP000002859304STRING: ENSP00000285930
    AOX1ENSP000003638324STRING: ENSP00000363832
    CYP2E1ENSP000002529454STRING: ENSP00000252945
    CYP2S1ENSP000003080324STRING: ENSP00000308032
    CYP2U1ENSP000003332124STRING: ENSP00000333212
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with CYP4X1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4X1 (CP4X1)

    Selected HMDB Compounds for CYP4X1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP4X1 gene: 
    NM_178033.1  

    Unigene Cluster for CYP4X1:

    Cytochrome P450, family 4, subfamily X, polypeptide 1
    Hs.439760  [show with all ESTs]
    Unigene Representative Sequence: NM_178033
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371901(uc001cqs.3 uc001cqt.3) ENST00000466294 ENST00000538609(uc001cqr.3)

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    Additional mRNA sequence: 

    AK091806.1 AK098065.1 AK131355.1 AM040940.1 AY358537.1 BC028102.1 

    8 DOTS entries:

    DT.210786  DT.102821989  DT.40110390  DT.99931108  DT.121412485  DT.121412526  DT.40281971  DT.95134706 

    Selected AceView cDNA sequences (see all 64):

    BQ023919 AI436648 NM_178033 AX747195 AK131355 AI923200 AI697332 AK098065 
    BC028102 BU684682 CD721887 CA438689 AK091806 AY358537 AA652746 AW264444 
    BF445825 BQ022205 D62878 BI523693 BM920917 BI916692 AA557324 R53457 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP4X1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGACCAA
    CYP4X1 Expression
    About this image


    CYP4X1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Kidney (Urinary System)
             Metanephros
    CYP4X1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4X1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439760

    UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Tissue specificity: Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In
    the heart, very high level levels in aorta, but very levels in other heart regions

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4X1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4x11 , 5 cytochrome P450, family 4, subfamily x, polypeptide more1, 5 81.07(n)1
    71.2(a)1
      4 (52.76 cM)5
    819061  NM_001003947.11  NP_001003947.11 
     1151063235 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    50(a)
    49(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343249.1(1835205-1850589)
    GL343249.1(1863196-1879999)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP714A11 CYP714A1 43.66(n)
    30.73(a)
      832560  NM_122400.2  NP_568463.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g01197001 Os11g0119700 42.98(n)
    30.95(a)
      4349623  NM_001072135.1  NP_001065603.1 


    ENSEMBL Gene Tree for CYP4X1 (if available)
    TreeFam Gene Tree for CYP4X1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4X1 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  
    13 SIMAP similar genes for CYP4X1 using alignment to 1 protein entry:     CP4X1_HUMAN:
    CYP4Z1    CYP4Z2P    CYP4A11    CYP4B1    CYP4F12    CYP4F11
    CYP4F3    CYP4F2    CYP4F8    DKFZp761K058    CYP4F22    CYP4A22
    CYP4V2

    Find genes that share paralogs with CYP4X1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4X1 (see all 627)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563976191,2
    C--47497729(+) ACAAC-/AAAAAA 1 -- int10--------
    rs728926171,2
    C,F--47500747(+) TTGACC/TGATAG 1 -- int12Minor allele frequency- T:0.10WA 120
    rs341465211,2
    C--47502945(+) TTTTT-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs561654401,2
    C--47505383(+) TCAGG-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs581113791,2
    C--47507959(+) TTTTT-/TCGATT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs340004581,2
    C--47510212(+) ACCACTAC/-ATTAT 2 -- int1 cds11Minor allele frequency- -:0.50NA 2
    rs355045791,2
    C--47510496(+) TTTTT-/TCTGAG 1 -- int10--------
    rs573660271,2
    C--47513263(+) GTGTG-/TG/   
      TGTGTG
    CGTTT
    2 -- int1 cds10--------
    rs344828231,2
    C,F--47513752(+) TTTACA/-AAAAA 1 -- int13Minor allele frequency- -:0.50NA 6
    rs1404320301,2
    --47564733(+) AGTGAA/CGCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP4X1 (47427036 - 47516423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CYP4X1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871080CNV Gain21882294
    nsv871717CNV Gain21882294
    nsv870674CNV Gain21882294
    nsv461428CNV Gain19166990
    dgv220n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4X1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4X1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614999    OMIM disorders: --


    Find genes that share disorders with CYP4X1           About GenesLikeMe


    Export disorders for CYP4X1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4X1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CYP4X1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (PubMed id 12176035)1, 3 Bylund J....Harder D.R. (Biochem. Biophys. Res. Commun. 2002)
    5. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PubMed id 15797250)1, 9 Savas U....Johnson E.F. (Arch. Biochem. Biophys. 2005)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain. (PubMed id 16478468)2 Al-Anizy M.... Bell D.R. (FEBS J. 2006)
    9. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 260293 HGNC: 20244 AceView: CYP4X1 Ensembl:ENSG00000186377 euGenes: HUgn260293
    ECgene: CYP4X1 Kegg: 260293 H-InvDB: CYP4X1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP4X1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4X1 gene:
    Search GeneIP for patents involving CYP4X1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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