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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP4X1 Gene

protein-coding   GIFtS: 54
GCID: GC01P047489

Cytochrome P450, Family 4, Subfamily X, Polypeptide 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 4, Subfamily X, Polypeptide 11 2
CYPIVX12 3
Cytochrome P450 4X12
EC 1.14.14.13

External Ids:    HGNC: 202441   Entrez Gene: 2602932   Ensembl: ENSG000001863777   OMIM: 6149995   UniProtKB: Q8N1183   

Export aliases for CYP4X1 gene to outside databases

Previous GC identifers: GC00U991261 GC01U900708 GC01P046859 GC01P047201 GC01P047261 GC01P045605


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP4X1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in
neurovascular function in the brain. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4X1 Gene: 
CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein-coding gene. Diseases associated with CYP4X1 include fascioliasis, and toxic encephalopathy, and among its related super-pathways are melatonin degradation I and nicotine degradation IV. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

Gene Wiki entry for CYP4X1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP4X1 gene promoter:
         NCX/Ncx   FOXL1   AREB6   RORalpha1   HEN1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP4X1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP4X1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4X1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33|1   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4X1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4X1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047489:  view genomic region     (about GC identifiers)

Start:
47,427,036 bp from pter      End:
47,516,423 bp from pter
Size:
89,388 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118 (See protein sequence)
Recommended Name: Cytochrome P450 4X1  
Size: 509 amino acids; 58875 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane (By similarity); Single-pass membrane protein (Potential).
Microsome membrane (By similarity)
Secondary accessions: G3V1U1 Q5VVE5 Q6ZN67 Q8NAZ3
Alternative splicing: 3 isoforms:  Q8N118-1   Q8N118-2   Q8N118-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP4X1: NX_Q8N118

Explore proteomics data for CYP4X1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N118

  • CYP4X1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP4X1 Protein Expression
    REFSEQ proteins: NP_828847.1  
    ENSEMBL proteins: 
     ENSP00000360968   ENSP00000445965  

    Human Recombinant Protein Products for CYP4X1: 
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    Cloud-Clone Corp. Proteins for CYP4X1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    CYP4X1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4X1 
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q8N118

    ProtoNet protein and cluster: Q8N118

    1 Blocks protein domain: IPB002401 E-class P450 group I signature

    UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Similarity: Belongs to the cytochrome P450 family


    CYP4X1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4X1_HUMAN, Q8N118
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Enzyme Number (IUBMB): EC 1.14.14.11

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
    GO:0070330aromatase activity IEA--
         
    CYP4X1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cyp4x1 (no phenotypes)

    CYP4X1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cyp4x1tm1Lex for CYP4X1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP4X1 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4X1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP4X1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1superpathway of melatonin degradation
    superpathway of melatonin degradation0.92
    melatonin degradation I0.92
    2nicotine degradation III
    nicotine degradation IV0.73
    nicotine degradation III0.73
    3acetone degradation I (to methylglyoxal)
    acetone degradation I (to methylglyoxal)0.44
    bupropion degradation0.44
    4Cytochrome P450 - arranged by substrate type
    cytochrome P4500.75
    5tryptophan utilization II
    tryptophan utilization I0.70

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9 BioSystems Pathways for CYP4X1 (see all 9)
        cytochrome P450
    nicotine degradation IV
    nicotine degradation III
    bupropion degradation
    melatonin degradation I



    1         Kegg Pathway  (Kegg details for CYP4X1):
        Serotonergic synapse


    CYP4X1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4X1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for CYP4X1 (ENSP000003609684) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1B1ENSP000002859304STRING: ENSP00000285930
    AOX1ENSP000003638324STRING: ENSP00000363832
    CYP2E1ENSP000002529454STRING: ENSP00000252945
    CYP2S1ENSP000003080324STRING: ENSP00000308032
    CYP2U1ENSP000003332124STRING: ENSP00000333212
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    CYP4X1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP4X1 (CP4X1)

    10/49 HMDB Compounds for CYP4X1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Search CenterWatch for drugs/clinical trials and news about CYP4X1 / CP4X1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP4X1 gene: 
    NM_178033.1  

    Unigene Cluster for CYP4X1:

    Cytochrome P450, family 4, subfamily X, polypeptide 1
    Hs.439760  [show with all ESTs]
    Unigene Representative Sequence: NM_178033
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371901(uc001cqs.3 uc001cqt.3) ENST00000466294 ENST00000538609(uc001cqr.3)


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    Additional mRNA sequence: 

    AK091806.1 AK098065.1 AK131355.1 AM040940.1 AY358537.1 BC028102.1 

    8 DOTS entries:

    DT.210786  DT.102821989  DT.40110390  DT.99931108  DT.121412485  DT.121412526  DT.40281971  DT.95134706 

    24/64 AceView cDNA sequences (see all 64):

    AX747195 BU684682 BF445825 AA652746 NM_178033 CD721887 AY358537 AI923200 
    AK131355 CA438689 AI436648 BC028102 AW264444 AI697332 AK098065 AK091806 
    BQ023919 BQ022205 CD511892 AA337301 BI772715 AI362521 BI669672 AL138223 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP4X1 expression in normal human tissues (normalized intensities)      CYP4X1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGACCAA
    CYP4X1 Expression
    About this image


    CYP4X1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Lung (Muscoskeletal System)    fully expand to see all 2 entries
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
             trachea   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Smooth Muscle (Muscoskeletal System)
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Bone (Muscoskeletal System)
             Human Calvarial Osteoblasts (HCO)   

    See CYP4X1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP4X1

    SOURCE GeneReport for Unigene cluster: Hs.439760

    UniProtKB/Swiss-Prot: CP4X1_HUMAN, Q8N118
    Tissue specificity: Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In
    the heart, very high level levels in aorta, but very levels in other heart regions

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4X1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYP4X1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4x11 , 5 cytochrome P450, family 4, subfamily x, polypeptide more1, 5 81.07(n)1
    71.2(a)1
      4 (52.76 cM)5
    819061  NM_001003947.11  NP_001003947.11 
     1151063235 
    chicken
    (Gallus gallus)
    Aves --
    CYP4B16
    Uncharacterized protein
    52(a)
    49(a)
    possible ortholog
    possible ortholog
    8(20771032-20780775)
    8(20783471-20790800)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    --
    50(a)
    50(a)
    (see all 6)
    many ↔ many
    possible ortholog
    (see all 6)
    GL343249.1(1835205-1850589)
    GL343249.1(1998735-2033839)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4t86
    cytochrome P450, family 4, subfamily T, polypeptid...
    45(a)
    1 → many
    16(5534736-5584736)


    ENSEMBL Gene Tree for CYP4X1 (if available)
    TreeFam Gene Tree for CYP4X1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP4X1 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  
    13 SIMAP similar genes for CYP4X1 using alignment to 1 protein entry:     CP4X1_HUMAN:
    CYP4Z1    CYP4Z2P    CYP4A11    CYP4B1    CYP4F12    CYP4F11
    CYP4F3    CYP4F8    DKFZp761K058    CYP4F2    CYP4F22    CYP4A22
    CYP4V2

    CYP4X1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/627 SNPs in CYP4X1 are shown (see all 627)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563976191,2
    C--47497729(+) ACAAC-/AAAAAA 1 -- int10--------
    rs728926171,2
    C,F--47500747(+) TTGACC/TGATAG 1 -- int12Minor allele frequency- T:0.10WA 120
    rs341465211,2
    C--47502945(+) TTTTT-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs561654401,2
    C--47505383(+) TCAGG-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs581113791,2
    C--47507959(+) TTTTT-/TCGATT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs340004581,2
    C--47510212(+) ACCACTAC/-ATTAT 2 -- int1 cds11Minor allele frequency- -:0.50NA 2
    rs355045791,2
    C--47510496(+) TTTTT-/TCTGAG 1 -- int10--------
    rs573660271,2
    C--47513263(+) GTGTG-/TG/   
      TGTGTG
    CGTTT
    2 -- int1 cds10--------
    rs344828231,2
    C,F--47513752(+) TTTACA/-AAAAA 1 -- int13Minor allele frequency- -:0.50NA 6
    rs1404320301,2
    --47564733(+) AGTGAA/CGCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP4X1 (47427036 - 47516423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CYP4X1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871080CNV Gain21882294
    nsv871717CNV Gain21882294
    nsv870674CNV Gain21882294
    nsv461428CNV Gain19166990
    dgv220n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614999    OMIM disorders: --

    15 diseases for CYP4X1:    About MalaCards
    fascioliasis    toxic encephalopathy    human immunodeficiency virus infectious disease    antley-bixler syndrome
    constipation    aspergillosis    cytochrome p450    porphyria
    candidiasis    diarrhea    brain disease    cholestasis
    hypercholesterolemia    skin disease    tuberculosis


    CYP4X1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CYP4X1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP4X1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CYP4X1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (PubMed id 12176035)1, 3 Bylund J....Harder D.R. (2002)
    5. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PubMed id 15797250)1, 9 Savas U....Johnson E.F. (2005)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain. (PubMed id 16478468)2 Al-Anizy M.... Bell D.R. (2006)
    9. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 260293 HGNC: 20244 AceView: CYP4X1 Ensembl:ENSG00000186377 euGenes: HUgn260293
    ECgene: CYP4X1 Kegg: 260293 H-InvDB: CYP4X1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP4X1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP4X1 gene:
    Search GeneIP for patents involving CYP4X1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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