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Aliases for CYP4X1 Gene

Aliases for CYP4X1 Gene

  • Cytochrome P450, Family 4, Subfamily X, Polypeptide 1 2 3
  • CYPIVX1 3 4
  • EC 1.14.14.1 4

External Ids for CYP4X1 Gene

Previous GeneCards Identifiers for CYP4X1 Gene

  • GC00U991261
  • GC01U900708
  • GC01P046859
  • GC01P047201
  • GC01P047261
  • GC01P047489
  • GC01P045605
  • GC01P047023

Summaries for CYP4X1 Gene

Entrez Gene Summary for CYP4X1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4X1 Gene

CYP4X1 (Cytochrome P450, Family 4, Subfamily X, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Biological oxidations. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F12.

Gene Wiki entry for CYP4X1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4X1 Gene

Genomics for CYP4X1 Gene

Regulatory Elements for CYP4X1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP4X1 Gene

Chromosome:
1
Start:
46,961,364 bp from pter
End:
47,050,751 bp from pter
Size:
89,388 bases
Orientation:
Plus strand

Genomic View for CYP4X1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4X1 Gene

Proteins for CYP4X1 Gene

  • Protein details for CYP4X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N118-CP4X1_HUMAN
    Recommended name:
    Cytochrome P450 4X1
    Protein Accession:
    Q8N118
    Secondary Accessions:
    • G3V1U1
    • Q5VVE5
    • Q6ZN67
    • Q8NAZ3

    Protein attributes for CYP4X1 Gene

    Size:
    509 amino acids
    Molecular mass:
    58875 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4X1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4X1 Gene

Proteomics data for CYP4X1 Gene at MOPED

Post-translational modifications for CYP4X1 Gene

  • Ubiquitination at Lys 75 and Lys 132
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP4X1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CYP4X1 Gene

Domains & Families for CYP4X1 Gene

Gene Families for CYP4X1 Gene

Protein Domains for CYP4X1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N118

UniProtKB/Swiss-Prot:

CP4X1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4X1: view

Function for CYP4X1 Gene

Molecular function for CYP4X1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Numbers (IUBMB) for CYP4X1 Gene

Gene Ontology (GO) - Molecular Function for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

Phenotypes for CYP4X1 Gene

genes like me logo Genes that share phenotypes with CYP4X1: view

Animal Model Products

miRNA for CYP4X1 Gene

miRTarBase miRNAs that target CYP4X1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4X1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4X1 Gene

Localization for CYP4X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4X1 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4X1 Gene COMPARTMENTS Subcellular localization image for CYP4X1 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

Pathways & Interactions for CYP4X1 Gene

genes like me logo Genes that share pathways with CYP4X1: view

Interacting Proteins for CYP4X1 Gene

Gene Ontology (GO) - Biological Process for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

No data available for SIGNOR curated interactions for CYP4X1 Gene

Drugs & Compounds for CYP4X1 Gene

(17) Drugs for CYP4X1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 485
Codeine Approved, Illicit Pharma Full agonist, Agonist 62
Estradiol Approved, Investigational Pharma Sex hormone 1057
Estrone Approved Pharma Agonist Estrogenic hormone 18
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453

(24) Additional Compounds for CYP4X1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP4X1: view

Transcripts for CYP4X1 Gene

mRNA/cDNA for CYP4X1 Gene

Unigene Clusters for CYP4X1 Gene

Cytochrome P450, family 4, subfamily X, polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4X1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4X1 Gene

No ASD Table

Relevant External Links for CYP4X1 Gene

GeneLoc Exon Structure for
CYP4X1
ECgene alternative splicing isoforms for
CYP4X1

Expression for CYP4X1 Gene

mRNA expression in normal human tissues for CYP4X1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CYP4X1 Gene

This gene is overexpressed in Breast (38.5), Heart (9.0), and Fetal Brain (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP4X1 Gene



SOURCE GeneReport for Unigene cluster for CYP4X1 Gene Hs.439760

mRNA Expression by UniProt/SwissProt for CYP4X1 Gene

Q8N118-CP4X1_HUMAN
Tissue specificity: Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.
genes like me logo Genes that share expression patterns with CYP4X1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CYP4X1 Gene

Orthologs for CYP4X1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4X1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100847677 35
  • 79.37 (n)
  • 67.66 (a)
CYP4X1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP4X1 35
  • 84.32 (n)
  • 74.51 (a)
CYP4X1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp4x1 35
  • 81.07 (n)
  • 71.2 (a)
Cyp4x1 16
Cyp4x1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC456833 35
  • 99.61 (n)
  • 99.61 (a)
CYP4X1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4x1 35
  • 80.47 (n)
  • 70.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP714A1 35
  • 43.66 (n)
  • 30.73 (a)
rice
(Oryza sativa)
Liliopsida Os11g0119700 35
  • 42.98 (n)
  • 30.95 (a)
Species with no ortholog for CYP4X1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4X1 Gene

ENSEMBL:
Gene Tree for CYP4X1 (if available)
TreeFam:
Gene Tree for CYP4X1 (if available)

Paralogs for CYP4X1 Gene

(13) SIMAP similar genes for CYP4X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP4X1: view

Variants for CYP4X1 Gene

Sequence variations from dbSNP and Humsavar for CYP4X1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs905379 -- 47,015,320(-) TTCCA(C/T)GCAAA intron-variant
rs1039468 -- 47,040,680(+) ATATA(C/T)ATGTA intron-variant
rs1117514 -- 47,041,169(+) tacca(C/T)gtttt intron-variant
rs1354262 -- 47,002,490(+) TGTAA(A/G)AACAA intron-variant, upstream-variant-2KB
rs1354263 -- 46,996,583(-) TTATT(A/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4X1 Gene

Variant ID Type Subtype PubMed ID
dgv220n71 CNV Gain 21882294
nsv870674 CNV Gain 21882294
nsv871717 CNV Gain 21882294
nsv461428 CNV Gain 19166990
nsv871080 CNV Gain 21882294

Variation tolerance for CYP4X1 Gene

Residual Variation Intolerance Score: 57.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4X1 Gene

HapMap Linkage Disequilibrium report
CYP4X1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4X1 Gene

Disorders for CYP4X1 Gene

Relevant External Links for CYP4X1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4X1
genes like me logo Genes that share disorders with CYP4X1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4X1 Gene

Publications for CYP4X1 Gene

  1. Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells. (PMID: 16527260) Thomas R.D. … Runge-Morris M. (Chem. Biol. Interact. 2006) 23 67
  2. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 23 67
  3. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (PMID: 12176035) Bylund J. … Harder D.R. (Biochem. Biophys. Res. Commun. 2002) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67

Products for CYP4X1 Gene

Sources for CYP4X1 Gene

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