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CYP4X1 Gene(Protein Coding)

Cytochrome P450 Family 4 Subfamily X Member 1

GCID:
GC01P046961
GIFtS:
52
Genes Participants
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Aliases for CYP4X1 Gene

Aliases for CYP4X1 Gene

  • Cytochrome P450 Family 4 Subfamily X Member 1 2 3 5
  • Cytochrome P450, Family 4, Subfamily X, Polypeptide 1 2 3
  • CYPIVX1 3 4
  • Cytochrome P450 4X1 3
  • EC 1.14.14.1 4

External Ids for CYP4X1 Gene

Previous GeneCards Identifiers for CYP4X1 Gene

  • GC00U991261
  • GC01U900708
  • GC01P046859
  • GC01P047201
  • GC01P047261
  • GC01P047489
  • GC01P045605
  • GC01P047023

Summaries for CYP4X1 Gene

Entrez Gene Summary for CYP4X1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CYP4X1 Gene

CYP4X1 (Cytochrome P450 Family 4 Subfamily X Member 1) is a Protein Coding gene. Among its related pathways are Serotonergic synapse and nicotine degradation IV. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4Z1.

Gene Wiki entry for CYP4X1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4X1 Gene

Genomics for CYP4X1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CYP4X1 Gene

Enhancers for CYP4X1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G046749 1.1 ENCODE dbSUPER 5.7 -211.5 -211525 1.6 HDGF YBX3 PKNOX1 SAP130 RBBP5 CEBPG ZNF384 YBX1 FOSL1 ZNF316 EFCAB14 CYP4B1 EFCAB14-AS1 CYP4X1 MKNK1 GC01P046743
GH01G047030 1 Ensembl ENCODE 5.4 +69.7 69723 1.4 NFIB ZNF76 FEZF1 ZNF7 ZNF366 ZBTB48 FOS ZNF600 PRDM10 ZNF10 POMGNT1 CYP4Z1 CYP4A22 CYP4X1 GC01M047004
GH01G046804 1.1 Ensembl ENCODE dbSUPER 4.6 -155.2 -155216 4.2 PKNOX1 HLF CEBPB CREB1 MAX REST PRDM10 NR3C1 NR2F2 CYP4B1 CYP4A11 CYP4X1 GC01M046749 LOC100533627
GH01G047408 0.8 ENCODE 4.5 +448.0 448046 2.2 PKNOX1 SIN3A ZIC2 YY1 ZFHX2 EGR1 ZNF600 MAFK TFE3 FOXA3 CMPK1 CYP4X1 FOXE3 GC01M047395
GH01G046954 0.5 ENCODE 0.4 -6.4 -6379 1.7 ZNF263 ZBTB40 EZH2 CYP4A11 CYP4B1 CYP4X1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP4X1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYP4X1 gene promoter:

Genomic Location for CYP4X1 Gene

Chromosome:
1
Start:
46,961,364 bp from pter
End:
47,050,751 bp from pter
Size:
89,388 bases
Orientation:
Plus strand

Genomic View for CYP4X1 Gene

Genes around CYP4X1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4X1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4X1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP4X1 Gene

Proteins for CYP4X1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CYP4X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N118-CP4X1_HUMAN
    Recommended name:
    Cytochrome P450 4X1
    Protein Accession:
    Q8N118
    Secondary Accessions:
    • G3V1U1
    • Q5VVE5
    • Q6ZN67
    • Q8NAZ3

    Protein attributes for CYP4X1 Gene

    Size:
    509 amino acids
    Molecular mass:
    58875 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4X1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4X1 Gene

Protein Expression for CYP4X1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CYP4X1 Gene

  • Ubiquitination at isoforms=2, 375 and isoforms=2, 3132
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP4X1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4X1 Gene

Domains & Families for CYP4X1 Gene

Gene Families for CYP4X1 Gene

HGNC:
IUPHAR :

Protein Domains for CYP4X1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP4X1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N118

UniProtKB/Swiss-Prot:

CP4X1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4X1: view

Function for CYP4X1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CYP4X1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.

Enzyme Numbers (IUBMB) for CYP4X1 Gene

Gene Ontology (GO) - Molecular Function for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYP4X1: view
genes like me logo Genes that share phenotypes with CYP4X1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP4X1

CRISPR Products

miRNA for CYP4X1 Gene

miRTarBase miRNAs that target CYP4X1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4X1 Gene

Localization for CYP4X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4X1 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4X1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

Pathways & Interactions for CYP4X1 Gene

genes like me logo Genes that share pathways with CYP4X1: view

Pathways by source for CYP4X1 Gene

1 KEGG pathway for CYP4X1 Gene

Gene Ontology (GO) - Biological Process for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

No data available for SIGNOR curated interactions for CYP4X1 Gene

Drugs & Compounds for CYP4X1 Gene

Products:

  1. Drug

(18) Drugs for CYP4X1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 512
Codeine Approved, Illicit Pharma Full agonist, Agonist 77
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1318
Estrone Approved Pharma Agonist Estrogenic hormone 21
Formaldehyde Approved, Vet_approved Pharma 93

(23) Additional Compounds for CYP4X1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
 81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
 219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP4X1: view

Transcripts for CYP4X1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CYP4X1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4X1 Gene

Cytochrome P450, family 4, subfamily X, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4X1 Gene

No ASD Table

Relevant External Links for CYP4X1 Gene

GeneLoc Exon Structure for
CYP4X1
ECgene alternative splicing isoforms for
CYP4X1

Expression for CYP4X1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4X1 Gene

mRNA expression in normal human tissues for CYP4X1 Gene
mRNA expression by BioGPS for CYP4X1 GenemRNA expression by GTEx for CYP4X1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CYP4X1 Gene

This gene is overexpressed in Breast (38.5), Heart (9.0), and Fetal Brain (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP4X1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYP4X1 Gene:

CYP4X1

SOURCE GeneReport for Unigene cluster for CYP4X1 Gene:

Hs.439760

mRNA Expression by UniProt/SwissProt for CYP4X1 Gene:

Q8N118-CP4X1_HUMAN
Tissue specificity: Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.

Evidence on tissue expression from TISSUES for CYP4X1 Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CYP4X1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4X1 Gene

Orthologs for CYP4X1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4X1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CYP4X1 35
  • 100 (a)
 OneToOne
LOC456833 34
  • 99.61 (n)
dog
(Canis familiaris)
 Mammalia CYP4X1 34 35
  • 84.32 (n)
mouse
(Mus musculus)
 Mammalia Cyp4x1 34 16 35
  • 81.07 (n)
rat
(Rattus norvegicus)
 Mammalia Cyp4x1 34
  • 80.47 (n)
cow
(Bos Taurus)
 Mammalia LOC100847677 34
  • 79.37 (n)
CYP4X1 35
  • 66 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 54 (a)
 ManyToMany
-- 35
  • 43 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 45 (a)
 ManyToMany
-- 35
  • 43 (a)
 ManyToMany
-- 35
  • 39 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 50 (a)
 ManyToMany
-- 35
  • 49 (a)
 ManyToMany
-- 35
  • 47 (a)
 ManyToMany
-- 35
  • 47 (a)
 ManyToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons CYP714A1 34
  • 43.66 (n)
rice
(Oryza sativa)
 Liliopsida Os11g0119700 34
  • 42.98 (n)
Species where no ortholog for CYP4X1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4X1 Gene

ENSEMBL:
Gene Tree for CYP4X1 (if available)
TreeFam:
Gene Tree for CYP4X1 (if available)

Paralogs for CYP4X1 Gene

Paralogs for CYP4X1 Gene

(13) SIMAP similar genes for CYP4X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP4X1: view

Variants for CYP4X1 Gene

Sequence variations from dbSNP and Humsavar for CYP4X1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000020617 -- 46,973,586(+) ATTTT(A/G)TTACT intron-variant
rs1000029265 -- 47,020,842(+) ATTTC(A/G)GTCAA intron-variant
rs1000041905 -- 47,008,791(+) ACAGA(C/T)TTTAA intron-variant
rs1000073847 -- 47,016,734(+) TTTGT(A/G)TTACA intron-variant
rs1000110607 -- 46,966,388(+) TATCT(C/G)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4X1 Gene

Variant ID Type Subtype PubMed ID
dgv32e212 CNV gain 25503493
esv2763300 CNV gain 21179565
esv3585949 CNV loss 21293372
esv3585950 CNV gain 21293372
nsv1009338 CNV gain 25217958
nsv1077760 OTHER inversion 25765185
nsv461428 CNV gain 19166990
nsv546166 CNV loss 21841781
nsv546167 CNV gain 21841781

Variation tolerance for CYP4X1 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4X1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4X1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4X1 Gene

Disorders for CYP4X1 Gene

Relevant External Links for CYP4X1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4X1

No disorders were found for CYP4X1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4X1 Gene

Publications for CYP4X1 Gene

  1. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (PMID: 12176035) Bylund J. … Harder D.R. (Biochem. Biophys. Res. Commun. 2002) 2 3 64

Products for CYP4X1 Gene

Sources for CYP4X1 Gene

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