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Aliases for CYP4V2 Gene

Aliases for CYP4V2 Gene

  • Cytochrome P450 Family 4 Subfamily V Member 2 2 3 5
  • Cytochrome P450, Family 4, Subfamily V, Polypeptide 2 2 3
  • Docosahexaenoic Acid Omega-Hydroxylase CYP4V2 3 4
  • Cytochrome P450 4V2 3
  • EC 1.14.13.199 4
  • EC 1.14.14.1 61
  • EC 1.14.13.- 4
  • CYP4AH1 3
  • BCD 3

External Ids for CYP4V2 Gene

Previous GeneCards Identifiers for CYP4V2 Gene

  • GC00U916976
  • GC04P187488
  • GC04P187349
  • GC04P187112
  • GC04P182864

Summaries for CYP4V2 Gene

Entrez Gene Summary for CYP4V2 Gene

  • This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4V2 Gene

CYP4V2 (Cytochrome P450 Family 4 Subfamily V Member 2) is a Protein Coding gene. Diseases associated with CYP4V2 include Bietti Crystalline Corneoretinal Dystrophy and Corneal Dystrophy. Among its related pathways are the visual cycle I (vertebrates) and Metabolism of fat-soluble vitamins. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F11.

UniProtKB/Swiss-Prot for CYP4V2 Gene

  • Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).

Gene Wiki entry for CYP4V2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4V2 Gene

Genomics for CYP4V2 Gene

Regulatory Elements for CYP4V2 Gene

Enhancers for CYP4V2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G186189 1.4 ENCODE dbSUPER 49.4 -0.1 -84 4.4 HNRNPUL1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 KLF13 MXD4 CYP4V2 FAM149A KLKB1 ORAOV1P1
GH04G186203 1.1 ENCODE dbSUPER 27.3 +13.3 13318 3.2 CBX3 ATF1 TBL1XR1 CREB3L1 TCF12 EGR1 ZNF366 SCRT2 CREM EGR2 CYP4V2 KLKB1 FLJ38576
GH04G186201 1.3 Ensembl ENCODE dbSUPER 17.3 +10.6 10629 0.9 SIN3A DMAP1 RAD21 YY1 EGR1 ZNF143 CREM EGR2 ZNF654 MXD4 CYP4V2 KLKB1 FLJ38576
GH04G186240 0.8 ENCODE dbSUPER 20.3 +51.7 51684 5.3 ZNF585B POLR2A CHD1 MNT CYP4V2 KLKB1 F11 GC04M186242
GH04G186246 1.3 Ensembl ENCODE dbSUPER 11.6 +57.9 57890 6.6 SOX13 IRF2 TAF1 TEAD4 ZMYM3 MAX CHD7 YY1 GATA2 POLR2A KLKB1 CYP4V2 F11 GC04M186242
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP4V2 on UCSC Golden Path with GeneCards custom track

Promoters for CYP4V2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177135 289 2601 HNRNPUL1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 KLF13 MXD4

Genomic Location for CYP4V2 Gene

Chromosome:
4
Start:
186,191,411 bp from pter
End:
186,213,463 bp from pter
Size:
22,053 bases
Orientation:
Plus strand

Genomic View for CYP4V2 Gene

Genes around CYP4V2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4V2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4V2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4V2 Gene

Proteins for CYP4V2 Gene

  • Protein details for CYP4V2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWL3-CP4V2_HUMAN
    Recommended name:
    Cytochrome P450 4V2
    Protein Accession:
    Q6ZWL3
    Secondary Accessions:
    • B7U6W2
    • Q6ZTM4

    Protein attributes for CYP4V2 Gene

    Size:
    525 amino acids
    Molecular mass:
    60724 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4V2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4V2 Gene

Selected DME Specific Peptides for CYP4V2 Gene

Q6ZWL3:
  • ICETAMG
  • DIREEVDTFMFEGHDTT
  • PFSAGPRNCIGQKFA
  • RLFPSVP

Post-translational modifications for CYP4V2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4V2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP4V2 Gene

Gene Families for CYP4V2 Gene

Protein Domains for CYP4V2 Gene

Suggested Antigen Peptide Sequences for CYP4V2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZWL3

UniProtKB/Swiss-Prot:

CP4V2_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4V2: view

Function for CYP4V2 Gene

Molecular function for CYP4V2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=65 uM for myristic acid {ECO:0000269 PubMed:19661213}; KM=140 uM for lauric acid {ECO:0000269 PubMed:19661213}; KM=430 uM for palmitic acid {ECO:0000269 PubMed:19661213}; Note=Vmax is the nearly the same for myristic acid and for lauric acid and reduced about 30% for palmitic acid. {ECO:0000269 PubMed:19661213};
UniProtKB/Swiss-Prot CatalyticActivity:
Docosahexaenoate + NADPH + O(2) = 22-hydroxydocosahexaenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-hydroxy-N-(4-n-butyl-2-methylphenyl formamidine)(HET0016) with an IC(50) of 38 nM.
UniProtKB/Swiss-Prot Function:
Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).

Enzyme Numbers (IUBMB) for CYP4V2 Gene

Gene Ontology (GO) - Molecular Function for CYP4V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP4V2: view
genes like me logo Genes that share phenotypes with CYP4V2: view

Human Phenotype Ontology for CYP4V2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYP4V2 Gene

MGI Knock Outs for CYP4V2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CYP4V2 Gene

Localization for CYP4V2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4V2 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4V2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP4V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4V2: view

Pathways & Interactions for CYP4V2 Gene

genes like me logo Genes that share pathways with CYP4V2: view

UniProtKB/Swiss-Prot Q6ZWL3-CP4V2_HUMAN

  • Pathway: Lipid metabolism.

Gene Ontology (GO) - Biological Process for CYP4V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process IEA --
GO:0007601 visual perception IEA --
GO:0010430 fatty acid omega-oxidation IDA 19661213
GO:0016125 sterol metabolic process TAS --
genes like me logo Genes that share ontologies with CYP4V2: view

No data available for SIGNOR curated interactions for CYP4V2 Gene

Drugs & Compounds for CYP4V2 Gene

(1) Drugs for CYP4V2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYP4V2: view

Transcripts for CYP4V2 Gene

Unigene Clusters for CYP4V2 Gene

Cytochrome P450, family 4, subfamily V, polypeptide 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4V2 Gene

No ASD Table

Relevant External Links for CYP4V2 Gene

GeneLoc Exon Structure for
CYP4V2
ECgene alternative splicing isoforms for
CYP4V2

Expression for CYP4V2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4V2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4V2 Gene

This gene is overexpressed in Liver (x5.6).

Protein differential expression in normal tissues from HIPED for CYP4V2 Gene

This gene is overexpressed in Adrenal (24.8), Prostate (12.5), Liver (10.6), and Gallbladder (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP4V2 Gene



Protein tissue co-expression partners for CYP4V2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP4V2 Gene:

CYP4V2

SOURCE GeneReport for Unigene cluster for CYP4V2 Gene:

Hs.587231

mRNA Expression by UniProt/SwissProt for CYP4V2 Gene:

Q6ZWL3-CP4V2_HUMAN
Tissue specificity: Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.

Evidence on tissue expression from TISSUES for CYP4V2 Gene

  • Kidney(4.6)
  • Liver(4.5)
  • Eye(4.4)
  • Nervous system(3.2)
  • Lung(2.6)
  • Blood(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4V2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • lymphatic
  • nervous
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
Thorax:
  • thymus
Abdomen:
  • liver
  • spleen
General:
  • blood
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with CYP4V2: view

Primer Products

Orthologs for CYP4V2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4V2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC744981 34
  • 99.05 (n)
CYP4V2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102152484 34
  • 84.7 (n)
CYP4V2 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYP4V2 34 35
  • 83.08 (n)
rat
(Rattus norvegicus)
Mammalia Cyp4v3 34
  • 82.63 (n)
mouse
(Mus musculus)
Mammalia Cyp4v3 34 16 35
  • 82.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYP4V2 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP4V2 34 35
  • 66.19 (n)
lizard
(Anolis carolinensis)
Reptilia CYP4V2 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485929 34
  • 64.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10792 34
zebrafish
(Danio rerio)
Actinopterygii cyp4v7 35
  • 63 (a)
OneToMany
cyp4v8 35
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp4c3 34 35
  • 53.44 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000194 34
  • 53.16 (n)
worm
(Caenorhabditis elegans)
Secernentea cyp-32A1 34 35
  • 53.08 (n)
cyp-31A2 35
  • 44 (a)
OneToMany
cyp-31A3 35
  • 44 (a)
OneToMany
cyp-37A1 35
  • 41 (a)
OneToMany
cyp-42A1 35
  • 41 (a)
OneToMany
cyp-31A5 35
  • 40 (a)
OneToMany
cyp-32B1 35
  • 39 (a)
OneToMany
cyp-37B1 35
  • 38 (a)
OneToMany
cyp-29A4 35
  • 36 (a)
OneToMany
cyp-29A2 35
  • 34 (a)
OneToMany
cyp-29A3 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8596 34
Species where no ortholog for CYP4V2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP4V2 Gene

ENSEMBL:
Gene Tree for CYP4V2 (if available)
TreeFam:
Gene Tree for CYP4V2 (if available)

Paralogs for CYP4V2 Gene

Variants for CYP4V2 Gene

Sequence variations from dbSNP and Humsavar for CYP4V2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs119103282 Pathogenic, Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370] 186,191,953(+) GGAAA(A/C/T)GGCAG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs119103283 Pathogenic, Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370] 186,196,007(+) GGTAA(C/G/T)TTTAA intron-variant, reference, missense
rs119103284 Pathogenic, Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370] 186,210,586(+) TCTTC(A/G)TCCAA reference, missense
rs119103285 Pathogenic, Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370] 186,192,004(+) TGGTG(A/G)GCCAC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs149684063 other, Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370] 186,196,042(+) CCTCT(A/G)TGTAC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP4V2 Gene

Variant ID Type Subtype PubMed ID
dgv1052e214 CNV gain 21293372
dgv683n27 CNV gain 19166990
dgv9426n54 CNV gain 21841781
esv2728930 CNV deletion 23290073
esv3603517 CNV gain 21293372
esv3603523 CNV gain 21293372
esv3603525 CNV loss 21293372
esv3894090 CNV gain 25118596
nsv1028146 CNV gain 25217958
nsv1131851 CNV deletion 24896259
nsv461864 CNV gain 19166990
nsv4642 CNV deletion 18451855
nsv4644 CNV insertion 18451855
nsv470097 CNV gain 18288195
nsv508340 CNV deletion 20534489
nsv596392 CNV gain 21841781
nsv596401 CNV loss 21841781
nsv830172 CNV loss 17160897

Variation tolerance for CYP4V2 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4V2 Gene

Human Gene Mutation Database (HGMD)
CYP4V2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4V2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4V2 Gene

Disorders for CYP4V2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CYP4V2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bietti crystalline corneoretinal dystrophy
  • bietti's crystalline dystrophy
corneal dystrophy
telangiectatic osteogenic sarcoma
  • telangiectatic osteosarcoma
localized osteosarcoma
  • localized osteogenic sarcoma
conventional central osteosarcoma
  • conventional osteosarcoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CP4V2_HUMAN
  • Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370]: An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. {ECO:0000269 PubMed:15042513, ECO:0000269 PubMed:22772592}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CYP4V2

Genetic Association Database (GAD)
CYP4V2
Human Genome Epidemiology (HuGE) Navigator
CYP4V2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4V2
genes like me logo Genes that share disorders with CYP4V2: view

No data available for Genatlas for CYP4V2 Gene

Publications for CYP4V2 Gene

  1. Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2. (PMID: 15042513) Li A. … Hejtmancik J.F. (Am. J. Hum. Genet. 2004) 2 3 4 22 64
  2. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. (PMID: 19278955) TrAcgouAt D.A. … Morange P.E. (Blood 2009) 3 46 64
  5. Genetic variants associated with deep vein thrombosis: the F11 locus. (PMID: 19583818) Li Y. … Rosendaal F.R. (J. Thromb. Haemost. 2009) 3 46 64

Products for CYP4V2 Gene

Sources for CYP4V2 Gene

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