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CYP4F8 Gene

protein-coding   GIFtS: 59
GCID: GC19P015726

Cytochrome P450, Family 4, Subfamily F, Polypeptide 8

(Previous names: cytochrome P450, subfamily IVF, polypeptide 8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome P450, Family 4, Subfamily F, Polypeptide 81 2     Cytochrome P450 4F82
Cytochrome P450, Subfamily IVF, Polypeptide 81 2     Flavoprotein-Linked Monooxygenase2
CYPIVF82 3     Microsomal Monooxygenase2
CPF82     EC 1.14.14.13

External Ids:    HGNC: 26481   Entrez Gene: 112832   Ensembl: ENSG000001865267   OMIM: 6115455   UniProtKB: P981873   
ORGUL members:         

Export aliases for CYP4F8 gene to outside databases

Previous GC identifers: GC19P016105 GC19P016014 GC19P015481 GC19P015587 GC19P015293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4F8 Gene:
This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase
of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.
Another member of this family, CYP4F3, is approximately 18 kb away. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4F8 Gene:
CYP4F8 (cytochrome P450, family 4, subfamily F, polypeptide 8) is a protein-coding gene. Diseases associated with CYP4F8 include congenital ichthyosiform erythroderma, and psoriasis. GO annotations related to this gene include electron carrier activity and heme binding.

UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187
Function: Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against
prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of
PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and
7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic
acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin

Gene Wiki entry for CYP4F8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4F8 gene promoter:
         C/EBPbeta   NF-1   Elk-1   Pax-5   p300   Brachyury   CUTL1   C/EBPalpha   c-Ets-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP4F8 promoter sequence
   Search Chromatin IP Primers for CYP4F8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4F8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

CYP4F8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4F8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015726:  view genomic region     (about GC identifiers)

Start:
15,726,029 bp from pter      End:
15,741,448 bp from pter
Size:
15,420 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187 (See protein sequence)
Recommended Name: Cytochrome P450 4F8  
Size: 520 amino acids; 59995 Da
Cofactor: Heme group (By similarity)

Explore the universe of human proteins at neXtProt for CYP4F8: NX_P98187

Explore proteomics data for CYP4F8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP4F8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009184.1  Reactome Protein details: P98187

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4F8
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P98187

    ProtoNet protein and cluster: P98187

    UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187
    Similarity: Belongs to the cytochrome P450 family


    CYP4F8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4F8_HUMAN, P98187
    Function: Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against
    prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of
    PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and
    7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic
    acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069); KM=40
    uM for 6,9-alpha-methylene-PGI2; Note=The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol
    enzyme;

         Genatlas biochemistry entry for CYP4F8:
    cytochrome p450,subfamily IV-F expressed in seminal vesicles,catalyzing in the synthesis of
    19R-hydroxyprostaglandins by a NADPH-dependent omega2-hydroxylation

         Enzyme Number (IUBMB): EC 1.14.14.11

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0018685alkane 1-monooxygenase activity TAS10405341
    GO:0020037heme binding IEA--
    GO:0070330aromatase activity IEA--
         
    CYP4F8 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4F8_HUMAN, P98187: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome
    membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytoskeleton1
    cytosol1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    CYP4F8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4F8 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Eicosanoids0.00
    cytochrome P4500.74
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    Arachidonic acid metabolism0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP4F8
        cytochrome P450
    metapathway biotransformation

    3 Reactome Pathways for CYP4F8
        Fatty acids
    Eicosanoids
    Synthesis of Leukotrienes (LT) and Eoxins (EX)


    2 Kegg Pathways  (Kegg details for CYP4F8):
        Arachidonic acid metabolism
    Metabolic pathways


    CYP4F8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F8: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4F8

    1 Interacting protein for CYP4F8 (P981873) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBNLQ9UJU63I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006690icosanoid metabolic process TAS--
    GO:0006693prostaglandin metabolic process TAS10405341
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CYP4F8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4F8 (CP4F8)

    9 HMDB Compounds for CYP4F8    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    17-HETE17-hydroxyeicosatetraenate (see all 3)----
    2beta-Hydroxytestosterone2beta,17beta-dihydroxyandrost-4-en-3-one 10390-14-4--
    5-Oxo-6-trans-leukotriene B45-oxo-6E-LTB(,4) (see all 3)----
    6,7-dihydro-12-epi-LTB46,7-dihydro-12-epi-leukotriene B(,4) (see all 4)----
    6,7-dihydro-5-oxo-12-epi-LTB46,7-dihydro-5-oxo-12-epi-leukotriene B(,4) (see all 4)----
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    5 Novoseek inferred chemical compound relationships for CYP4F8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    19-hydroxy-pge2 98.7 1 10791960 (1)
    pgh2 86.2 1 15789615 (1)
    leukotriene b4 59.4 1 10791960 (1)
    arachidonic acid 50.1 3 10791960 (2), 15789615 (1)
    prostaglandin 44.3 2 10791960 (1)



    CYP4F8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP4F8 gene: 
    NM_007253.3  

    Unigene Cluster for CYP4F8:

    Cytochrome P450, family 4, subfamily F, polypeptide 8
    Hs.268554  [show with all ESTs]
    Unigene Representative Sequence: AK092612
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592615(processed_transcript) ENST00000443973(processed_transcript) ENST00000325723(processed_transcript) ENST00000590209(processed_transcript) ENST00000589019(processed_transcript)
    ENST00000589787(processed_transcript) ENST00000587680(processed_transcript) ENST00000589927(processed_transcript) ENST00000585349(processed_transcript) ENST00000590745(processed_transcript)
    ENST00000589778(processed_transcript) ENST00000589722(processed_transcript) ENST00000441682(processed_transcript)
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    Additional mRNA sequence: 

    AF133298.1 AK092612.1 AK300478.1 AK300530.1 AK300539.1 AK314685.1 

    8 DOTS entries:

    DT.65285431  DT.100019481  DT.121503049  DT.75105325  DT.100019480  DT.121503069  DT.91734181  DT.102819406 

    Selected AceView cDNA sequences (see all 60):

    AW583946 AW195123 AI805346 BX096931 BG740260 BV204775 BG741262 CD609759 
    AA757354 AI393075 BX500988 AI805531 BE465164 NM_007253 AW582923 BV200157 
    BG563580 BE856034 BG743661 AI241490 BG741091 AI086199 BG697441 C01672 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F8 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -           -           -                                   -                                       
    SP2:                                -           -           -                                                                           
    SP3:                                                                                            -                       -               
    SP4:                                                                                                                                    
    SP5:              -                 -                                                                                                   


    ECgene alternative splicing isoforms for CYP4F8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CYP4F8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTGAAGG
    CYP4F8 Expression
    About this image


    CYP4F8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
     
     Prostate (Endocrine System)
    CYP4F8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4F8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268554

    UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187
    Tissue specificity: Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in
    epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas
    deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and
    ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the
    corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of
    psoriatic lesions

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F8: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4F8 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4f151 , 5 cytochrome P450, family 4, subfamily f, polypeptide more1, 5 78.52(n)1
    76.88(a)1
      17 (17.76 cM)5
    1066481  NM_134127.11  NP_598888.11 
     326856275 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP72A151 CYP72A15 43.55(n)
    34.03(a)
      820697  NM_112330.3  NP_188087.1 


    ENSEMBL Gene Tree for CYP4F8 (if available)
    TreeFam Gene Tree for CYP4F8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4F8 gene
    13 SIMAP similar genes for CYP4F8 using alignment to 1 protein entry:     CP4F8_HUMAN:
    CYP4F2    CYP4F11    DKFZp761K058    CYP4F12    CYP4F3    CYP4F22
    CYP4B1    CYP4X1    CYP4Z1    CYP4A11    CYP4Z2P    CYP4V2
    CYP4A22

    CYP4F8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP4F8
    PGOHUM00000260433


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4F8 (see all 507)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348653251,2
    C,F--15295824(+) CAAAAG/-GTGCT 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1996768881,2
    C--15295824(+) CAAAAA/GGTGCT 1 -- int10--------
    rs2011455661,2
    --15305471(+) ATCTA-/TCTATC 1 -- int10--------
    rs575587131,2
    C--15305489(+) CTATC-/TATCTA 1 -- int10--------
    rs1402210791,2
    C--15308749(+) GAAGA-/TTTTTTT 1 -- ds50010--------
    rs37645641,2
    C,F,A,H--15656270(-) CCAAGG/TTTCAT 1 -- us2k131Minor allele frequency- N:0.00EA NA NS WA CSA 4458
    rs1487911181,2
    --15656321(+) TGCTCA/GTGGCT 1 -- us2k10--------
    rs37645631,2
    C,F,A,H--15656375(-) GGAAGC/TGAAAT 1 -- us2k130Minor allele frequency- T:0.06EA NA NS WA CSA 4041
    rs1834183131,2
    --15656388(+) CCTTGA/GCCTTC 1 -- us2k10--------
    rs37645621,2
    C,F,A--15656445(-) TCCTTT/CGCAGT 1 -- us2k1 trp312Minor allele frequency- C:0.21EA NA CSA WA 1996

    HapMap Linkage Disequilibrium report for CYP4F8 (15726029 - 15741448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP4F8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv627e199CNV Deletion23128226
    esv2718235CNV Deletion23290073
    esv1497518CNV Insertion17803354
    nsv911139CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4F8
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4F8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611545    OMIM disorders: --

    5 diseases for CYP4F8:    
    About MalaCards
    congenital ichthyosiform erythroderma    psoriasis    tuberculosis    prostate cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CYP4F8:
    Congenital ichthyosiform erythroderma

    CYP4F8 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYP4F8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 45.7 4 16516815 (2), 12464258 (1)

    Genetic Association Database (GAD): CYP4F8
    Human Genome Epidemiology (HuGE) Navigator: CYP4F8 (2 documents)

    Export disorders for CYP4F8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4F8 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CYP4F8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. (PubMed id 10405341)1, 2, 3 Bylund J.... Oliw E.H. (Biochem. Biophys. Res. Commun. 1999)
    2. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. (PubMed id 12464258)1, 2, 9 Stark K.... Oliw E.H. (Arch. Biochem. Biophys. 2003)
    3. On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. (PubMed id 15789615)1, 2, 9 Stark K.... Oliw E.H. (Prostaglandins Other Lipid Mediat. 2005)
    4. Identification of CYP4F8 in human seminal vesicles as a prominent 19- hydroxylase of prostaglandin endoperoxides. (PubMed id 10791960)1, 2, 9 Bylund J.... Oliw E.H. (J. Biol. Chem. 2000)
    5. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (Pharmacogenet. Genomics 2012)
    6. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    7. Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. (PubMed id 16112640)1, 2 Stark K.... Oliw E.H. (Arch. Biochem. Biophys. 2005)
    8. Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer. (PubMed id 21281786)1 Vainio P....Iljin K. (Am. J. Pathol. 2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11283 HGNC: 2648 AceView: CYP4F3andCYP4F8 Ensembl:ENSG00000186526 euGenes: HUgn11283
    ECgene: CYP4F8 Kegg: 11283 H-InvDB: CYP4F8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP4F8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4F8 gene:
    Search GeneIP for patents involving CYP4F8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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