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Aliases for CYP4F8 Gene

Aliases for CYP4F8 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 8 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 8 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 8 2 3
  • CYPIVF8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Cytochrome P450 4F8 3
  • EC 1.14.14.1 4
  • CPF8 3

External Ids for CYP4F8 Gene

Previous GeneCards Identifiers for CYP4F8 Gene

  • GC19P016105
  • GC19P016014
  • GC19P015481
  • GC19P015587
  • GC19P015726
  • GC19P015293

Summaries for CYP4F8 Gene

Entrez Gene Summary for CYP4F8 Gene

  • This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F8 Gene

CYP4F8 (Cytochrome P450 Family 4 Subfamily F Member 8) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F2.

UniProtKB/Swiss-Prot for CYP4F8 Gene

  • Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.

Gene Wiki entry for CYP4F8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F8 Gene

Genomics for CYP4F8 Gene

Regulatory Elements for CYP4F8 Gene

Enhancers for CYP4F8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F015635 0.4 FANTOM5 12.9 +20.4 20382 0.2 TFAP4 HLF FOXA3 CEBPB ZNF644 RAD21 ATF3 CEBPA CYP4F8 HSH2D RAB8A CYP4F3 BRD4 AKAP8 GC19M015646
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CYP4F8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4F8 Gene

Chromosome:
19
Start:
15,615,218 bp from pter
End:
15,631,867 bp from pter
Size:
16,650 bases
Orientation:
Plus strand

Genomic View for CYP4F8 Gene

Genes around CYP4F8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F8 Gene

Proteins for CYP4F8 Gene

  • Protein details for CYP4F8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98187-CP4F8_HUMAN
    Recommended name:
    Cytochrome P450 4F8
    Protein Accession:
    P98187

    Protein attributes for CYP4F8 Gene

    Size:
    520 amino acids
    Molecular mass:
    59995 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4F8 Gene

Post-translational modifications for CYP4F8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F8 Gene

No data available for DME Specific Peptides for CYP4F8 Gene

Domains & Families for CYP4F8 Gene

Gene Families for CYP4F8 Gene

Protein Domains for CYP4F8 Gene

Suggested Antigen Peptide Sequences for CYP4F8 Gene

Graphical View of Domain Structure for InterPro Entry

P98187

UniProtKB/Swiss-Prot:

CP4F8_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F8: view

Function for CYP4F8 Gene

Molecular function for CYP4F8 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily IV-F expressed in seminal vesicles,catalyzing in the synthesis of 19R-hydroxyprostaglandins by a NADPH-dependent omega2-hydroxylation
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069); KM=40 uM for 6,9-alpha-methylene-PGI2; Note=The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol enzyme.;
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.

Enzyme Numbers (IUBMB) for CYP4F8 Gene

Gene Ontology (GO) - Molecular Function for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0018685 alkane 1-monooxygenase activity TAS 10405341
GO:0019825 oxygen binding TAS --
genes like me logo Genes that share ontologies with CYP4F8: view

Phenotypes for CYP4F8 Gene

genes like me logo Genes that share phenotypes with CYP4F8: view

Animal Model Products

miRNA for CYP4F8 Gene

miRTarBase miRNAs that target CYP4F8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F8 Gene

Localization for CYP4F8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F8 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.

Gene Ontology (GO) - Cellular Components for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

No data available for Subcellular locations from COMPARTMENTS for CYP4F8 Gene

Pathways & Interactions for CYP4F8 Gene

genes like me logo Genes that share pathways with CYP4F8: view

Pathways by source for CYP4F8 Gene

Interacting Proteins for CYP4F8 Gene

Gene Ontology (GO) - Biological Process for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006690 icosanoid metabolic process TAS --
GO:0006693 prostaglandin metabolic process TAS 10405341
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

No data available for SIGNOR curated interactions for CYP4F8 Gene

Drugs & Compounds for CYP4F8 Gene

(5) Drugs for CYP4F8 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
arachidonic acid Experimental Nutra Activator 28
Leukotriene B4 Pharma BLT1/BLT2 receptor agonist and potent chemotactic factor 0
heme Pharma Agonist 0

(8) Additional Compounds for CYP4F8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
20-Hydroxy-leukotriene B4
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoate
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
79516-82-8
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with CYP4F8: view

Transcripts for CYP4F8 Gene

Unigene Clusters for CYP4F8 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for CYP4F8 Gene

GeneLoc Exon Structure for
CYP4F8
ECgene alternative splicing isoforms for
CYP4F8

Expression for CYP4F8 Gene

mRNA expression in normal human tissues for CYP4F8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x28.2), Prostate (x9.2), Skin - Sun Exposed (Lower leg) (x7.0), and Bladder (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of CYP4F8 Gene:

CYP4F8

SOURCE GeneReport for Unigene cluster for CYP4F8 Gene:

Hs.268554

mRNA Expression by UniProt/SwissProt for CYP4F8 Gene:

P98187-CP4F8_HUMAN
Tissue specificity: Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions.
genes like me logo Genes that share expression patterns with CYP4F8: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CYP4F8 Gene

Orthologs for CYP4F8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748442 34
  • 99.17 (n)
mouse
(Mus musculus)
Mammalia Cyp4f15 34 16
  • 78.52 (n)
rat
(Rattus norvegicus)
Mammalia Cyp4f4 34
  • 78.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cyp4d2 36
  • 38 (a)
Cyp4c3 36
  • 37 (a)
Cyp4d8 36
  • 36 (a)
Cyp4d14 36
  • 35 (a)
Cyp4g15 36
  • 35 (a)
Cyp4ae1 36
  • 34 (a)
Cyp4d1 36
  • 34 (a)
Cyp4d20 36
  • 34 (a)
Cyp4s3 36
  • 34 (a)
Cyp4ac3 36
  • 33 (a)
Cyp4p1 36
  • 33 (a)
Cyp4ac1 36
  • 32 (a)
Cyp4ac2 36
  • 32 (a)
Cyp4d21 36
  • 32 (a)
Cyp4e2 36
  • 32 (a)
Cyp4e3 36
  • 32 (a)
Cyp4p2 36
  • 32 (a)
Cyp4p3 36
  • 32 (a)
Cyp4e1 36
  • 31 (a)
Cyp311a1 36
  • 30 (a)
Cyp312a1 36
  • 30 (a)
Cyp4aa1 36
  • 30 (a)
Cyp313a4 36
  • 29 (a)
Cyp4ad1 36
  • 29 (a)
Cyp4g1 36
  • 26 (a)
Cyp313b1 36
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea Y17G9B.3 36
  • 36 (a)
B0331.1 36
  • 35 (a)
F01D5.9 36
  • 35 (a)
Y5H2B.5 36
  • 35 (a)
Y38C9B.1 36
  • 34 (a)
F28G4.1 36
  • 33 (a)
C26F1.2 36
  • 32 (a)
Y80D3A.5 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP72A15 34
  • 43.55 (n)
Species where no ortholog for CYP4F8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP4F8 Gene

ENSEMBL:
Gene Tree for CYP4F8 (if available)
TreeFam:
Gene Tree for CYP4F8 (if available)

Paralogs for CYP4F8 Gene

(13) SIMAP similar genes for CYP4F8 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CYP4F8 Gene

genes like me logo Genes that share paralogs with CYP4F8: view

Variants for CYP4F8 Gene

Sequence variations from dbSNP and Humsavar for CYP4F8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402709 -- 15,621,790(+) CCTCT(A/C)CCCCA intron-variant
rs10405202 -- 15,624,799(+) gtggg(C/T)aaagt intron-variant
rs10415724 -- 15,627,310(+) ctata(C/T)taaaa intron-variant
rs10417069 -- 15,615,178(+) AGCCC(A/C)GCCCA upstream-variant-2KB
rs111417224 -- 15,615,170(+) CTAGT(-/CCAGCCCAGC)CCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYP4F8 Gene

Variant ID Type Subtype PubMed ID
dgv3443n100 CNV gain 25217958
dgv3444n100 CNV gain 25217958
dgv3445n100 CNV gain 25217958
dgv627e199 CNV deletion 23128226
esv1497518 CNV insertion 17803354
esv2718235 CNV deletion 23290073
nsv1064684 CNV gain 25217958
nsv1066963 CNV gain 25217958
nsv1066993 CNV gain 25217958
nsv1072865 CNV deletion 25765185
nsv1127656 CNV deletion 24896259
nsv1134756 CNV deletion 24896259

Relevant External Links for CYP4F8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4F8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CYP4F8 Gene

Disorders for CYP4F8 Gene

Relevant External Links for CYP4F8

Genetic Association Database (GAD)
CYP4F8
Human Genome Epidemiology (HuGE) Navigator
CYP4F8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F8

No disorders were found for CYP4F8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4F8 Gene

Publications for CYP4F8 Gene

  1. On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. (PMID: 15789615) Stark K. … Oliw E.H. (Prostaglandins Other Lipid Mediat. 2005) 3 4 22 64
  2. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. (PMID: 12464258) Stark K. … Oliw E.H. (Arch. Biochem. Biophys. 2003) 3 4 22 64
  3. Identification of CYP4F8 in human seminal vesicles as a prominent 19- hydroxylase of prostaglandin endoperoxides. (PMID: 10791960) Bylund J. … Oliw E.H. (J. Biol. Chem. 2000) 3 4 22 64
  4. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. (PMID: 10405341) Bylund J. … Oliw E.H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
  5. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 3 46 64

Products for CYP4F8 Gene

Sources for CYP4F8 Gene

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