CYP4F8 Gene
protein-coding GIFtS: 53
GCID: GC19P015726
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|
cytochrome P450, family 4, subfamily F, polypeptide 8(Previous names: cytochrome P450, subfamily IVF, polypeptide 8 )
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Aliases
for CYP4F8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 4, Subfamily F, Polypeptide 81 2 | | Cytochrome P450 4F82 | | Cytochrome P450, Subfamily IVF, Polypeptide 81 2 | | Flavoprotein-Linked Monooxygenase2 | | CYPIVF82 3 | | Microsomal Monooxygenase2 | | CPF82 | | EC 1.14.14.13 |
Export aliases for CYP4F8 gene to outside databasesPrevious GC identifers: GC19P016105 GC19P016014 GC19P015481 GC19P015587 GC19P015293 |
Summaries
for CYP4F8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP4F8:
This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandinsin seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of thisfamily, CYP4F3, is approximately 18 kb away. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187Function: Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity againstprostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid(22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin
Gene Wiki entry for CYP4F8
|
Genomic Views
for CYP4F8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP4F8 gene promoter:
C/EBPbeta NF-1 Elk-1 Pax-5 p300 Brachyury CUTL1 C/EBPalpha c-Ets-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP4F8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.1CYP4F8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P015726: view genomic region
(about GC identifiers)
Start:
|
15,726,029 bp from pter |
End:
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15,741,448 bp from pter |
Size:
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15,420 bases |
Orientation:
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plus strand |
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Proteins
for CYP4F8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187 (See
protein sequence)Recommended Name: Cytochrome P450 4F8 Size: 520 amino acids; 59995 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome membrane(By similarity)Explore the universe of human proteins at neXtProt for CYP4F8: NX_P98187
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P98187
CYP4F8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009184.1 Reactome Protein details: P98187
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CYP4F8 for ontologies About GeneDecksing
CYP4F8 Antibody Products:
Assay Products for CYP4F8: |
Protein
Domains /
Families
for CYP4F8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP4F8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P98187ProtoNet protein and cluster: P98187 UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187Similarity: Belongs to the cytochrome P450 family |
Function
for CYP4F8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187Function: Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity againstprostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid(22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclinCatalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)OBiophysicochemical properties: Kinetic parameters: KM=7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069); KM=40 uMfor 6,9-alpha-methylene-PGI2; Note=The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol enzyme; Genatlas biochemistry entry for CYP4F8:cytochrome p450,subfamily IV-F expressed in seminal vesicles,catalyzing in the synthesis of 19R-hydroxyprostaglandinsby a NADPH-dependent omega2-hydroxylation
Enzyme Number (IUBMB): EC 1.14.14.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F8 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP4F8 (NM_007253) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F8 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CYP4F8 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYP4F8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytochrome P450 - arranged by substrate type | | | 2 | Biological oxidations | | | 3 | Eicosanoids | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for CYP4F8
5 
Reactome Pathways for CYP4F8
CYP4F8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4F8
1 Interacting protein for CYP4F8 (P981873) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CYP4F8 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP4F8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP4F8 for compounds About GeneDecksing
 Browse Tocris compounds for CYP4F8
9 HMDB Compounds for CYP4F8 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 10-HETE | 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2) | 167697-52-1 | -- | | 11beta-Hydroxytestosterone | 11beta,17beta-dihydroxyandrost-4-en-3-one | 1816-85-9 | -- | | 13-HETE | 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2) | 151910-72-4 | -- | | 17-HETE | 17-hydroxyeicosatetraenate (see all 3) | -- | -- | | 2beta-Hydroxytestosterone | 2beta,17beta-dihydroxyandrost-4-en-3-one | 10390-14-4 | -- | | 5-Oxo-6-trans-leukotriene B4 | 5-oxo-6E-LTB(,4) (see all 3) | -- | -- | | 6,7-dihydro-12-epi-LTB4 | 6,7-dihydro-12-epi-leukotriene B(,4) (see all 4) | -- | -- | | 6,7-dihydro-5-oxo-12-epi-LTB4 | 6,7-dihydro-5-oxo-12-epi-leukotriene B(,4) (see all 4) | -- | -- | | Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
5 Novoseek chemical compound relationships for CYP4F8 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 19-hydroxy-pge2 |
98.7 |
1 |
10791960 (1) |
| pgh2 |
86.2 |
1 |
15789615 (1) |
| leukotriene b4 |
59.4 |
1 |
10791960 (1) |
| arachidonic acid |
50.1 |
3 |
10791960 (2), 15789615 (1) |
| prostaglandin |
44.3 |
2 |
10791960 (1) |
Search CenterWatch for drugs/clinical trials and news about CYP4F8 / CP4F8
|
Transcripts
for CYP4F8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP4F8 gene: NM_007253.3 Unigene Cluster for CYP4F8: Cytochrome P450, family 4, subfamily F, polypeptide 8 Hs.268554 [show with all ESTs]Unigene Representative Sequence: AK09261213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592615 ENST00000443973(uc010xoi.1) ENST00000325723 ENST00000590209
ENST00000589019 ENST00000589787 ENST00000589778 ENST00000587680 ENST00000589927
ENST00000585349 ENST00000590745 ENST00000589722 ENST00000441682(uc002nbi.3 uc010xoj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F8 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP4F8 (NM_007253) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F8 |
Additional cDNA sequence: AF133298.1 AK092612.1 AK300478.1 AK300530.1 AK300539.1 AK314685.1 8 DOTS entries: DT.65285431 DT.100019481 DT.121503049 DT.75105325 DT.100019480 DT.121503069 DT.91734181 DT.102819406 24/60 AceView cDNA sequences (see all 60): AW583946 AW195123 AI805346 BG697441 BX470297 BG741060 CD609759 AF054821 D12621 BG743402 AI086199 BG563580 NM_007253 BX470287 AK096809 AW117235 BM977622 BV200157 BG743661 AW582923 BE465164 BV204775 AI241490 C01672
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F8 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYP4F8
|
Expression
for CYP4F8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP4F8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTGAAGG
About this image
See CYP4F8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4F8
SOURCE GeneReport for Unigene cluster: Hs.268554
UniProtKB/Swiss-Prot: CP4F8_HUMAN, P98187Tissue specificity: Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, inepidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferensand of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (atprotein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the cornealepithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriaticlesions
SABiosciences Expression via Pathway-Focused PCR Array including CYP4F8: | Drug Metabolism: Phase I Enzymes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP4F8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F8 |
Orthologs
for CYP4F8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYP4F8 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for CYP4F8 (if available)
TreeFam Gene Tree for CYP4F8 (if available) |
Paralogs
for CYP4F8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP4F8 gene
13 SIMAP similar genes for CYP4F8 using alignment to 1 protein entry: CP4F8_HUMAN:CYP4F2 CYP4F11 DKFZp761K058 CYP4F3 CYP4F12 CYP4F22
CYP4B1 CYP4X1 CYP4Z1 CYP4A11 CYP4Z2P CYP4V2
CYP4A22
CYP4F8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CYP4F8
PGOHUM00000260433
|
Genomic Variants
for CYP4F8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP4F8 (15726029 - 15741448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP4F8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F8 |
|
Disorders
/ Diseases
for CYP4F8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP4F8 for disorders About GeneDecksing
OMIM gene information: 611545
OMIM disorders: --
7  diseases for CYP4F8: About MalaCardscongenital ichthyosiform erythroderma cholesterol psoriasis prostate cancer
prostatitis tuberculosis mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for CYP4F8:Congenital ichthyosiform erythroderma 1 Novoseek disease relationship for CYP4F8 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| psoriasis |
45.7 |
4 |
16516815 (2), 12464258 (1) |
Human Genome Epidemiology (HuGE) Navigator: CYP4F8 (2 documents)
Export disorders for CYP4F8 gene to outside databases
|
Publications
for CYP4F8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP4F8 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CYP4F8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. (PubMed id 10405341)1, 2, 3 Bylund J.... Oliw E.H. (1999)
- Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. (PubMed id 12464258)1, 2, 9 Stark K....Oliw E.H. (2003)
- On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. (PubMed id 15789615)1, 2, 9 Stark K.... Oliw E.H. (2005)
- Identification of CYP4F8 in human seminal vesicles as a prominent 19- hydroxylase of prostaglandin endoperoxides. (PubMed id 10791960)1, 2, 9 Bylund J.... Oliw E.H. (2000)
- Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. (PubMed id 16112640)1, 2 Stark K....Oliw E.H. (2005)
- A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)1 Aslibekyan S....Arnett D.K. (2012)
- Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer . (PubMed id 21281786)1 Vainio P....Iljin K. (2011)
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for CYP4F8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP4F8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP4F8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP4F8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CYP4F8 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CYP4F8 gene:
Search GeneIP for patents involving CYP4F8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYP4F8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP4F8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP4F8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F8 | | | OriGene Protein Over-expression Lysate for CYP4F8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP4F8 | | OriGene 3'-UTR Clone for CYP4F8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP4F8 | | OriGene Custom Protein Services for CYP4F8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP4F8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP4F8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F8 |
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| | | | Search Tocris compounds for CYP4F8 |
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 | | | CYP4F8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F8 |
|  |  |  | | | | ThermoFisher Antibodies for CYP4F8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F8 |
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