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CYP4F3 Gene

protein-coding   GIFtS: 64
GCID: GC19P015751

Cytochrome P450, Family 4, Subfamily F, Polypeptide 3

(Previous names: cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene...)
(Previous symbol: LTB4H)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 4, Subfamily F, Polypeptide 31 2     CPF32
LTB4H1 2 3 5     CYP4F2
Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega
Hydroxylase)1 2
     Cytochrome P-4502
Cytochrome P450 4F32 3     Leukotriene B4 Omega Hydroxylase2
Cytochrome P450-LTB-Omega2 3     Leukotriene-B(4) Omega-Hydroxylase 22
Leukotriene-B(4) 20-Monooxygenase 22 3     Leukotriene-B4 20-Monooxygenase2
CYPIVF32 3     EC 1.14.13.303

External Ids:    HGNC: 26461   Entrez Gene: 40512   Ensembl: ENSG000001865297   OMIM: 6012705   UniProtKB: Q084773   

Export aliases for CYP4F3 gene to outside databases

Previous GC identifers: GC19P016130 GC19P016013 GC19P015482 GC19P015612 GC19P015320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4F3 Gene:
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of
inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of
cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three
transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CYP4F3 Gene:
CYP4F3 (cytochrome P450, family 4, subfamily F, polypeptide 3) is a protein-coding gene. Diseases associated with CYP4F3 include ascariasis, and trichuriasis. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and
NADPH. Isoform CYP4F3A catalyzes the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear
leukocytes, it has low activity for arachidonic acid
Function: Isoform CYP4F3B: Has a 30-fold higher Km for LTB4 compared with CYP4F3A, but it utilizes arachidonic
acid as a substrate for omega-hydroxylation and generates 20-HETE, an activator of kinases PKC and CK2

summary for CYP4F3 Gene:
Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs
are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.
CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate
and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential
for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They
are found at high levels in the liver, where they have an important role in metabolism of drugs and
endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this
accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,
cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP4F3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4F3 gene promoter:
         c-Fos   Elk-1   AP-1   Brachyury   NRSF form 1   FosB   NRSF form 2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP4F3 promoter sequence
   Search Chromatin IP Primers for CYP4F3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

CYP4F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4F3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015751:  view genomic region     (about GC identifiers)

Start:
15,751,707 bp from pter      End:
15,773,635 bp from pter
Size:
21,929 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477 (See protein sequence)
Recommended Name: Leukotriene-B(4) omega-hydroxylase 2  
Size: 520 amino acids; 59847 Da
Cofactor: Heme group (By similarity)
Secondary accessions: B7Z8Z3 O60634 Q5U740
Alternative promoter usage, Alternative splicing: 2 isoforms:  Q08477-1   Q08477-2   

Explore the universe of human proteins at neXtProt for CYP4F3: NX_Q08477

Explore proteomics data for CYP4F3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP4F3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000887.2  NP_001186137.1  NP_001186138.1  

    ENSEMBL proteins: 
     ENSP00000466395   ENSP00000466988   ENSP00000221307   ENSP00000465394   ENSP00000468105  
     ENSP00000476546  
    Reactome Protein details: Q08477

    CYP4F3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CYP4F3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4F3
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q08477

    ProtoNet protein and cluster: Q08477

    1 Blocks protein domain: IPB002402 Group II E-class P450 signature

    UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477
    Similarity: Belongs to the cytochrome P450 family


    CYP4F3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4F3_HUMAN, Q08477
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and
    NADPH. Isoform CYP4F3A catalyzes the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear
    leukocytes, it has low activity for arachidonic acid
    Function: Isoform CYP4F3B: Has a 30-fold higher Km for LTB4 compared with CYP4F3A, but it utilizes arachidonic
    acid as a substrate for omega-hydroxylation and generates 20-HETE, an activator of kinases PKC and CK2
    Catalytic activity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) =
    (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O
    Enzyme regulation: Inhibited by carbon monoxide (CO)

         Genatlas biochemistry entry for CYP4F3:
    cytochrome p450,subfamily IVF,polypeptide 3,59.8kDa,expressed in granulocytes,catalyzing the inactivation of
    leukotrienne beta 4 with two forms resulting from tissue specific splicing and alternative promoters

         Enzyme Number (IUBMB): EC 1.14.13.301

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity TAS8486631
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
    GO:0050051leukotriene-B4 20-monooxygenase activity IEA--
         
    CYP4F3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYP4F3:
     Elongated cells 

         1 MGI phenotypic allele for Cyp4f13 (no phenotypes)

    CYP4F3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4F3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP4F3
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CYP4F3 (NM_001199208)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4F3_HUMAN, Q08477: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome
    membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    peroxisome2
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    CYP4F3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4F3 About    
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    HETE and HPETE biosynthesis and metabolism0.33
    Arachidonic acid metabolism0.40
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Miscellaneous substrates0.00
    cytochrome P4500.74
    Eicosanoids0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYP4F3
        HETE and HPETE biosynthesis and metabolism

    2 BioSystems Pathways for CYP4F3
        cytochrome P450
    metapathway biotransformation

    4 Reactome Pathways for CYP4F3
        Miscellaneous substrates
    Fatty acids
    Eicosanoids
    Synthesis of Leukotrienes (LT) and Eoxins (EX)


    2 Kegg Pathways  (Kegg details for CYP4F3):
        Arachidonic acid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477
    Pathway: Lipid metabolism; leukotriene B4 degradation


    CYP4F3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F3: 

              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4F3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP4F3 (ENSP000002213074) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    CYP2C18ENSP000002859794STRING: ENSP00000285979
    CYP2C19ENSP000003603724STRING: ENSP00000360372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006690icosanoid metabolic process TAS--
    GO:0006691leukotriene metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CYP4F3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CYP4F3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Metyrapone11-beta hydroxylase inhibitor[54-36-4]
    DMOGProlylhydroxylase inhibitor[89464-63-1]
    Ro 61-8048Potent kynurenine 3-hydroxylase inhibitor[199666-03-0]

    Selected HMDB Compounds for CYP4F3 (see all 28)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-dihydro-20-dihydroxy-LTB410,11-dihydroxy-20-dihydroxy-LTB(,4) (see all 3)----
    10,11-dihydro-20-trihydroxy-leukotriene B4(5S,12R,20)-pentahydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 3)----
    12(S)-Leukotriene B42-epi-LTB4 (see all 7)83709-73-3--
    12-Keto-tetrahydro-leukotriene B412-keto-10,11,14,15-tetrahydro-LTB4 (see all 3)----
    12-Oxo-20-hydroxy-leukotriene B412-keto-20-hydroxy-leukotriene B(,4) (see all 6)----
    12-Oxo-20-trihydroxy-leukotriene B412-oxo-20,20,20-trihydroxy-leukotriene B(,4) (see all 6)----
    12-oxo-20-dihydroxy-leukotriene B412-oxo-20,20-dihydroxy-leukotriene B(,4) (see all 7)----
    13'-Carboxy-gama-tocopherol2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-chromanol;2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-hydroxychroman ----
    13'-Hydroxy-gama-tocopherol13'-OH-tocopherol ----
    13'-Hydroxy-gama-tocotrienol13OHgamaTE ----

    3 Novoseek inferred chemical compound relationships for CYP4F3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukotriene b4 86 24 10409674 (2), 9675028 (2), 9539102 (2), 12167568 (1) (see all 14)
    arachidonic acid 66.5 1 11162645 (1)
    clofibrate 64 1 12167568 (1)



    CYP4F3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP4F3 gene (3 alternative transcripts): 
    NM_000896.2  NM_001199208.1  NM_001199209.1  

    Unigene Cluster for CYP4F3:

    Cytochrome P450, family 4, subfamily F, polypeptide 3
    Hs.106242  [show with all ESTs]
    Unigene Representative Sequence: AB002454
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592279 ENST00000586182 ENST00000591058 ENST00000221307(uc010xok.2 uc010xol.2 uc002nbj.3 uc010xom.2 uc002nbk.3 uc010xon.2)
    ENST00000587360 ENST00000585846 ENST00000609670 ENST00000592424 ENST00000588886

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    Additional mRNA sequence: 

    AB002454.1 AF054821.1 AK296761.1 AK296802.1 AK298675.1 AK303477.1 AK304200.1 AK316136.1 
    BC136299.1 D12620.1 D12621.1 

    7 DOTS entries:

    DT.452202  DT.100779308  DT.100779307  DT.91683613  DT.91751549  DT.95372012  DT.101958587 

    Selected AceView cDNA sequences (see all 60):

    AW195123 AI805346 AW583946 CD609759 BX470297 AI393075 BV204775 BG740260 
    BG743661 BG743402 BG742486 AF133298 BX096931 BE856034 AA343177 AF054821 
    BM977622 BG741262 AI086199 BV200157 D12621 BG698525 BG698888 AI805531 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -           -                                 
    SP2:                          -                           
    SP3:                    -                                 
    SP4:        -                 -                           


    ECgene alternative splicing isoforms for CYP4F3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP4F3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP4F3 Expression
    About this image


    CYP4F3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Lens
    CYP4F3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4F3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106242

    UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477
    Tissue specificity: Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and
    bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F
    isoform in trachea and tissues of the gastrointestinal tract

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP4F3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4f131 , 5 cytochrome P450, family 4, subfamily f, polypeptide more1, 5 77.78(n)1
    73.6(a)1
      17 (17.98 cM)5
    1707161  NM_130882.11  NP_570952.11 
     329246885 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    73(a)
    1 → many
    AADN03027099.1(283-5104)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    62(a)
    many ↔ many
    many ↔ many
    AAWZ02039718(3621-5749)
    2(79856458-79966876)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4f36
    cytochrome P450, family 4, subfamily F, polypeptid...
    49(a)
    1 → many
    12(49851155-49871433) ENSDARG00000053530


    ENSEMBL Gene Tree for CYP4F3 (if available)
    TreeFam Gene Tree for CYP4F3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4F3 gene
    CYP4F222  TBXAS12  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    14 SIMAP similar genes for CYP4F3 using alignment to 3 protein entries:     CP4F3_HUMAN (see all proteins):
    CYP4F11    CYP4F2    DKFZp761K058    CYP4F8    CYP4F12    CYP4F22
    DKFZp686F1316    CYP4X1    CYP4B1    CYP4A11    CYP4Z1    CYP4Z2P
    CYP4A22    CYP4V2

    CYP4F3 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for CYP4F3 (see all 10)
    PGOHUM00000248289 PGOHUM00000234185 PGOHUM00000234531 PGOHUM00000240184 PGOHUM00000236081


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4F3 (see all 877)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609123441,2
    C--15335897(+) TCTAT-/C/    
       CTATC
    TTCTA
    3 -- int11CSA 2
    rs1881868971,2
    C--15681977(+) CTTTAC/TCAGGA 3 -- us2k10--------
    rs22393681,2
    C,A,H--15682066(+) TCAATA/GGGCTC 3 -- us2k110Minor allele frequency- G:0.36NA WA CSA EA 370
    rs22836071,2
    C,F,H--15682146(+) ACTCAA/GCTCAC 3 -- us2k18Minor allele frequency- G:0.36EA NS NA WA CSA 1735
    rs578661241,2
    --15682200(+) CCTCCC/TGAGTA 3 -- us2k10--------
    rs19153761,2
    --15682332(+) TGGCCC/TCCCAA 3 -- us2k10--------
    rs19153771,2
    C,H--15682356(+) CAGGCG/ATGAGC 3 -- us2k17Minor allele frequency- A:0.00NA WA CSA 13
    rs1870127121,2
    --15682408(+) GGTACC/TGAGTA 3 -- us2k10--------
    rs1395428951,2
    --15682431(+) GTAGCA/GCAGGC 3 -- us2k10--------
    rs1160982121,2
    F--15682441(+) CAAGAG/ATAGGA 3 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for CYP4F3 (15751707 - 15773635 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP4F3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2269626CNV Deletion18987734
    esv2718237CNV Deletion23290073
    dgv627e199CNV Deletion23128226
    esv2674388CNV Deletion23128226
    esv2718235CNV Deletion23290073
    esv2477444CNV Deletion19546169
    esv1597130CNV Insertion17803354
    nsv911143CNV Loss21882294
    dgv3749n71CNV Loss21882294
    dgv3748n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): CYP4F3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4F3
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4F3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601270    OMIM disorders: --

    8 diseases for CYP4F3:    
    About MalaCards
    ascariasis    trichuriasis    labyrinthitis    asthma
    hepatitis b    tuberculosis    hepatitis    cerebritis


    CYP4F3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYP4F3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 19 6 16926051 (2), 18433732 (1), 16835590 (1), 17884973 (1)

    Genetic Association Database (GAD): CYP4F3
    Human Genome Epidemiology (HuGE) Navigator: CYP4F3 (4 documents)

    Export disorders for CYP4F3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4F3 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with CYP4F3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. (PubMed id 9539102)1, 2, 3, 9 Kikuta Y....Kusunose M. (DNA Cell Biol. 1998)
    2. A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega- hydroxylase. (PubMed id 8486631)1, 2, 3 Kikuta Y.... Kusunose M. (J. Biol. Chem. 1993)
    3. Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. (PubMed id 10409674)1, 2, 9 Christmas P.... Soberman R.J. (J. Biol. Chem. 1999)
    4. Alternative splicing determines the function of CYP4F3 by switching substrate specificity. (PubMed id 11461919)1, 2, 9 Christmas P....Soberman R.J. (J. Biol. Chem. 2001)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. (PubMed id 12709424)1, 9 Christmas P....Soberman R.J. (J. Biol. Chem. 2003)
    7. Expression and physiological function of CYP4F subfamily in human eosinophils. (PubMed id 17980168)1, 9 Kikuta Y....Ohkawa H. (Biochim. Biophys. Acta 2007)
    8. CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. (PubMed id 18566475)1, 9 Antoun J....PlAce-Gautier E. (J. Lipid Res. 2008)
    9. Cloning and expression of a novel form of leukotriene B4 omega- hydroxylase from human liver. (PubMed id 8026587)1, 9 Kikuta Y....Kusunose M. (FEBS Lett. 1994)
    10. Human cytochrome P450 4F3: structure, functions, and prospects. (PubMed id 22706230)1 Corcos L....SalaA1n J.P. (Drug Metabol Drug Interact 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4051 HGNC: 2646 AceView: CYP4F3andCYP4F8 Ensembl:ENSG00000186529 euGenes: HUgn4051
    ECgene: CYP4F3 Kegg: 4051 H-InvDB: CYP4F3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP4F3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cyp4f3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4F3 gene:
    Search GeneIP for patents involving CYP4F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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