Aliases for CYP4F3 Gene
- Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 2 3
- Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega Hydroxylase) 2 3
- 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
- Leukotriene-B(4) Omega-Hydroxylase 2 3 4
- Leukotriene-B(4) 20-Monooxygenase 2 3 4
- Cytochrome P450-LTB-Omega 3 4
- Cytochrome P450 4F3 3 4
- 20-HETE Synthase 3 4
- CYPIVF3 3 4
- LTB4H 3 4
External Ids for CYP4F3 Gene
Previous HGNC Symbols for CYP4F3 Gene
Previous GeneCards Identifiers for CYP4F3 Gene
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for CYP4F3 Gene
CYP4F3 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 3) is a Protein Coding gene. Diseases associated with CYP4F3 include trichuriasis. Among its related pathways are Metabolism and Linoleic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F12.
UniProtKB/Swiss-Prot for CYP4F3 Gene
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).
Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 220.127.116.11), steroid 11-beta hydroxylase (E.C. 18.104.22.168), and LTB4 omega-hydroxylase (E.C. 22.214.171.124).