CYP4F3 Gene
protein-coding GIFtS: 63
GCID: GC19P015751
|
|
cytochrome P450, family 4, subfamily F, polypeptide 3(Previous names: cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene...)
(Previous symbol: LTB4H)
| |
Aliases
for CYP4F3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 4, Subfamily F, Polypeptide 31 2 | | CYPIVF32 3 | | LTB4H1 2 3 5 | | CPF32 | | CYP4F1 2 | | Cytochrome P-4502 | | Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 OmegaHydroxylase)1 2 | | Leukotriene B4 Omega Hydroxylase2 | | Cytochrome P450 4F32 3 | | Leukotriene-B(4) Omega-Hydroxylase 22 | | Cytochrome P450-LTB-Omega2 3 | | Leukotriene-B4 20-Monooxygenase2 | | Leukotriene-B(4) 20-Monooxygenase 22 3 | | EC 1.14.13.303 |
Export aliases for CYP4F3 gene to outside databasesPrevious GC identifers: GC19P016130 GC19P016013 GC19P015482 GC19P015612 GC19P015320 |
Summaries
for CYP4F3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP4F3:
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating anddegrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 geneson chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variantsencoding two different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)
UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPHfor the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes
 summary
for CYP4F3: Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs
are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.
CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate
and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential
for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They
are found at high levels in the liver, where they have an important role in metabolism of drugs and
endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this
accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,
cholesterol synthesis and vitamin D metabolism.
Gene Wiki entry for CYP4F3
|
Genomic Views
for CYP4F3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP4F3 gene promoter:
c-Fos Elk-1 AP-1 Brachyury NRSF form 1 FosB NRSF form 2 CREB deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP4F3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12CYP4F3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P015751: view genomic region
(about GC identifiers)
Start:
|
15,751,707 bp from pter |
End:
|
15,773,634 bp from pter |
Size:
|
21,928 bases |
Orientation:
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plus strand |
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Proteins
for CYP4F3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477 (See
protein sequence)Recommended Name: Leukotriene-B(4) omega-hydroxylase 2 Size: 520 amino acids; 59847 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome membrane;Single-pass membrane protein (By similarity)
Sequence caution: Sequence=AAC08589.1; Type=Frameshift; Positions=67, 114;
Secondary accessions: O60634 Q5U740Explore the universe of human proteins at neXtProt for CYP4F3: NX_Q08477
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08477
CYP4F3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000887.2 NP_001186137.1 NP_001186138.1
ENSEMBL proteins: ENSP00000466395 ENSP00000221307 ENSP00000466988 ENSP00000465394 ENSP00000468105 Reactome Protein details: Q08477
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CYP4F3 for ontologies About GeneDecksing
CYP4F3 Antibody Products:
Assay Products for CYP4F3: |
Protein
Domains /
Families
for CYP4F3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP4F3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08477ProtoNet protein and cluster: Q08477 1 Blocks protein family: IPB002402 Group II E-class P450 signature
UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477Similarity: Belongs to the cytochrome P450 family |
Function
for CYP4F3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPHfor the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytesCatalytic activity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) =(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)OEnzyme regulation: Inhibited by carbon monoxide (CO) Genatlas biochemistry entry for CYP4F3:cytochrome p450,subfamily IVF,polypeptide 3,59.8kDa,expressed in granulocytes,catalyzing the inactivation ofleukotrienne beta 4 with two forms resulting from tissue specific splicing and alternative promoters
Enzyme Number (IUBMB): EC 1.14.13.301
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CYP4F3 (NM_001199208) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F3 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004497 | monooxygenase activity |
TAS | 8486631 | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
-- | -- | | GO:0020037 | heme binding |
IEA | -- |
CYP4F3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CYP4F3:
Animal Models:
1 MGI phenotypic allele  for Cyp4f13 (no phenotypes)
CYP4F3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CYP4F3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Arachidonic acid metabolism | | | 2 | Cytochrome P450 - arranged by substrate type | | | 3 | Metabolism | | | 4 | Biological oxidations | | | 5 | Eicosanoids | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CYP4F3
1  GeneGo (Thomson Reuters) Pathway for CYP4F3
2  BioSystems Pathways for CYP4F3
5/8 
Reactome Pathways for CYP4F3 (see all 8)
2 
Kegg Pathways (Kegg details for CYP4F3):
UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477Pathway: Lipid metabolism; leukotriene B4 degradation
CYP4F3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4F3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for CYP4F3 (ENSP000002213074) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CYP4F3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP4F3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP4F3 for compounds About GeneDecksing
Compounds for CYP4F3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| 17-ODYA | LTB-omega-Hydroxylase inhibitor | [34450-18-5] |
10/28 HMDB Compounds for CYP4F3 (see all 28) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 10,11-dihydro-20-dihydroxy-LTB4 | 10,11-dihydroxy-20-dihydroxy-LTB(,4) (see all 3) | -- | -- | | 10,11-dihydro-20-trihydroxy-leukotriene B4 | (5S,12R,20)-pentahydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 3) | -- | -- | | 12(S)-Leukotriene B4 | 2-epi-LTB4 (see all 7) | 83709-73-3 | -- | | 12-Keto-tetrahydro-leukotriene B4 | 12-keto-10,11,14,15-tetrahydro-LTB4 (see all 3) | -- | -- | | 12-Oxo-20-hydroxy-leukotriene B4 | 12-keto-20-hydroxy-leukotriene B(,4) (see all 6) | -- | -- | | 12-Oxo-20-trihydroxy-leukotriene B4 | 12-oxo-20,20,20-trihydroxy-leukotriene B(,4) (see all 6) | -- | -- | | 12-oxo-20-dihydroxy-leukotriene B4 | 12-oxo-20,20-dihydroxy-leukotriene B(,4) (see all 7) | -- | -- | | 13'-Carboxy-gama-tocopherol | 2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-chromanol;2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-hydroxychroman | -- | -- | | 13'-Hydroxy-gama-tocopherol | 13'-OH-tocopherol | -- | -- | | 13'-Hydroxy-gama-tocotrienol | 13OHgamaTE | -- | -- |
3 Novoseek chemical compound relationships for CYP4F3 gene About this table
Search CenterWatch for drugs/clinical trials and news about CYP4F3 / CP4F3
|
Transcripts
for CYP4F3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP4F3 gene (3 alternative transcripts): NM_000896.2 NM_001199208.1 NM_001199209.1 Unigene Cluster for CYP4F3: Cytochrome P450, family 4, subfamily F, polypeptide 3 Hs.106242 [show with all ESTs]Unigene Representative Sequence: AB0024547 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586182 ENST00000592279 ENST00000221307(uc010xok.2 uc010xol.2 uc002nbj.3 uc010xom.2 uc002nbk.3 uc010xon.2)
ENST00000591058 ENST00000587360 ENST00000585846 ENST00000592424
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CYP4F3 (NM_001199208) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F3 |
Additional cDNA sequence: AB002454.1 AF054821.1 AK296761.1 AK296802.1 AK298675.1 AK303477.1 AK304200.1 AK316136.1 BC136299.1 D12620.1 D12621.1 7 DOTS entries: DT.452202 DT.100779308 DT.100779307 DT.91683613 DT.91751549 DT.95372012 DT.101958587 24/60 AceView cDNA sequences (see all 60): AW195123 AI805346 AW583946 AI805531 BG742486 BV200157 BG741262 AA757354 C01672 BX096931 BG743661 BX470297 AK096809 D12621 BE856034 AA343177 BG698888 AI393075 BV204775 BG740260 BG698525 AF054821 AW117235 BM977622
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F3 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | - | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CYP4F3
|
Expression
for CYP4F3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP4F3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CYP4F3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4F3
SOURCE GeneReport for Unigene cluster: Hs.106242
UniProtKB/Swiss-Prot: CP4F3_HUMAN, Q08477Tissue specificity: Expressed in the polymorphonuclear leukocytes as well as leukocytes
SABiosciences Expression via Pathway-Focused PCR Array including CYP4F3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP4F3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F3 |
Orthologs
for CYP4F3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYP4F3 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
63(a) |
1 → many |
2(79936816-79963743) |
zebrafish
(Danio rerio) |
Actinopterygii |
cyp4f36 |
cytochrome P450, family 4, subfamily F, polypeptid... |
48(a) |
1 → many |
12(49851155-49871433) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CYP72A96CYP72A146(see all 22) |
cytochrome P450, family 72, subfamily A, polypepti...cytochrome P450, family 72, subfamily A, polypepti...(see all 22) |
21(a)21(a)(see all 22) |
possible orthologpossible ortholog(see all 22) |
3(4917498-4919409) 3(4934420-4936563) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 42) |
cytochrome P450, putative, expressed(see all 42) |
26(a)25(a)(see all 42) |
possible orthologpossible ortholog(see all 42) |
12(909825-911396) 1(23662015-23663400) |
ENSEMBL Gene Tree for CYP4F3 (if available)
TreeFam Gene Tree for CYP4F3 (if available) |
Paralogs
for CYP4F3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP4F3 gene
- CYP4F222 CYP4F22 CYP4F112 CYP46A12 ENSG000002256072 CYP4B12 CYP3A52 CYP4X12
- TBXAS12 CYP3A42 CYP3A432 CYP3A72 CYP4V22 CYP4A222 CYP4A112 CYP4F122
- CYP4Z12
18 SIMAP similar genes for CYP4F3 using alignment to 3 protein entries: CP4F3_HUMAN (see all proteins):CYP4F2 CYP4F11 DKFZp761K058 CYP4F8 CYP4F12 CYP4F22
DKFZp686F1316 CYP4X1 CYP4B1 CYP4A11 CYP4Z1 CYP4Z2P
CYP3A43/CYP3A4 CYP3A5 CYP4V2 CYP4A22 CYP3A4 CYP2E1
CYP4F3 for paralogs About GeneDecksing
5/10 Pseudogenes.org Pseudogenes for CYP4F3 (see all 10)
PGOHUM00000248289 PGOHUM00000234185 PGOHUM00000234531 PGOHUM00000240184 PGOHUM00000236081
|
Genomic Variants
for CYP4F3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP4F3 (15751707 - 15773634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CYP4F3
4 CNVs: 102794 73316 29688 32230
3 Indels: 40269 45727 40268
Human Gene Mutation Database (HGMD): CYP4F3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F3 |
|
Disorders
/ Diseases
for CYP4F3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP4F3 for disorders About GeneDecksing
OMIM gene information: 601270
OMIM disorders: --
9  diseases for CYP4F3: About MalaCardscholesterol bronchial asthma ascariasis trichuriasis
hepatitis b asthma hepatitis tuberculosis
mycobacterium tuberculosis
1 Novoseek disease relationship for CYP4F3 gene About this table
Genetic Association Database (GAD): CYP4F3
Human Genome Epidemiology (HuGE) Navigator: CYP4F3 (4 documents)
Export disorders for CYP4F3 gene to outside databases
|
Publications
for CYP4F3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP4F3 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with CYP4F3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. (PubMed id 9539102)1, 2, 3, 9 Kikuta Y....Kusunose M. (1998)
- A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega- hydroxylase. (PubMed id 8486631)1, 2, 3 Kikuta Y.... Kusunose M. (1993)
- Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. (PubMed id 10409674)1, 9 Christmas P....Soberman R.J. (1999)
- Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. (PubMed id 12709424)1, 9 Christmas P....Soberman R.J. (2003)
- Expression and physiological function of CYP4F subfamily in human eosinophils. (PubMed id 17980168)1, 9 Kikuta Y....Ohkawa H. (2007)
- CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. (PubMed id 18566475)1, 9 Antoun J....Plee-Gautier E. (2008)
- Alternative splicing determines the function of CYP4F3 by switching substrate specificity. (PubMed id 11461919)1, 9 Christmas P....Soberman R.J. (2001)
- Cloning and expression of a novel form of leukotriene B4 omega- hydroxylase from human liver. (PubMed id 8026587)1, 9 Kikuta Y....Kusunose M. (1994)
- Human cytochrome P450 4F3: structure, functions, and p rospects. (PubMed id 22706230)1 Corcos L....Salaun J.P. (2012)
- Effects of chronic ascariasis and trichuriasis on cyt okine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)1 Reina Ortiz M....Cooper P.J. (2011)
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External Searches for CYP4F3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CYP4F3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CYP4F3 gene
(According to HUGE)
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Specialized Databases showing CYP4F3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CYP4F3 | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/cyp4f3/ |
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About This Section
| Patent Information for CYP4F3 gene:
Search GeneIP for patents involving CYP4F3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYP4F3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP4F3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP4F3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP4F3 | | OriGene 3'-UTR Clone for CYP4F3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP4F3 | | OriGene Custom Protein Services for CYP4F3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP4F3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP4F3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F3 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F3 |
|  |  |  | | | | ThermoFisher Antibodies for CYP4F3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F3 |
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