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CYP4F3 Gene(Protein Coding)

Cytochrome P450 Family 4 Subfamily F Member 3

GCID:
GC19P015640
GIFtS:
60
Genes Participants
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Aliases for CYP4F3 Gene

Aliases for CYP4F3 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 3 2 3 5
  • Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega Hydroxylase) 2 3
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 2 3
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Leukotriene-B(4) Omega-Hydroxylase 2 3 4
  • Leukotriene-B(4) 20-Monooxygenase 2 3 4
  • Cytochrome P450-LTB-Omega 3 4
  • Cytochrome P450 4F3 3 4
  • 20-HETE Synthase 3 4
  • CYPIVF3 3 4
  • LTB4H 3 4
  • Docosahexaenoic Acid Omega-Hydroxylase CYP4F3 3
  • Leukotriene B4 Omega Hydroxylase 3
  • Leukotriene-B4 20-Monooxygenase 3
  • Cytochrome P-450 3
  • EC 1.14.13.199 4
  • EC 1.14.13.30 4
  • EC 1.14.13.- 4
  • CYP4F 3
  • CPF3 3

External Ids for CYP4F3 Gene

Previous HGNC Symbols for CYP4F3 Gene

  • LTB4H

Previous GeneCards Identifiers for CYP4F3 Gene

  • GC19P016130
  • GC19P016013
  • GC19P015482
  • GC19P015612
  • GC19P015751
  • GC19P015320
  • GC19P015615

Summaries for CYP4F3 Gene

Entrez Gene Summary for CYP4F3 Gene

  • This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP4F3 Gene

CYP4F3 (Cytochrome P450 Family 4 Subfamily F Member 3) is a Protein Coding gene. Diseases associated with CYP4F3 include Inflammatory Bowel Disease 6 and Ascariasis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F2.

UniProtKB/Swiss-Prot for CYP4F3 Gene

  • Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.

  • Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Tocris Summary for CYP4F3 Gene

  • Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-beta hydroxylase (E.C. 1.14.15.4), and LTB4 omega-hydroxylase (E.C. 1.14.13.30).

Gene Wiki entry for CYP4F3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F3 Gene

Genomics for CYP4F3 Gene

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Regulatory Elements for CYP4F3 Gene

Enhancers for CYP4F3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G015639 1.6 FANTOM5 Ensembl ENCODE 13.1 +0.2 245 3.3 FOXA2 ARID4B SIN3A ZNF48 YY1 REST MIER2 ZNF579 SSRP1 MYNN CYP4F12 HSH2D CYP4F10P CYP4F3 OR10H5 RAB8A LINC01835 BRD4 AKAP8 GC19M015646
GH19G015584 1.2 Ensembl ENCODE 5 -56.2 -56161 0.7 RB1 ARID4B KLF17 DMAP1 ZNF2 ZNF48 ZSCAN9 ZBTB7B RAD21 ZNF155 AKAP8 CYP4F12 ZNF333 CYP4F11 OR10H5 CYP4F10P CYP4F24P CYP4F3 GC19P015580 GC19P015593
GH19G015587 0.8 Ensembl ENCODE 5.3 -53.0 -52997 1.0 CTCF GATA3 HLF MAX MYC SPI1 CYP4F12 CYP4F11 OR10H5 CYP4F24P CYP4F3 GC19P015580 GC19P015593
GH19G015499 1 FANTOM5 ENCODE 3.1 -141.7 -141659 0.3 PKNOX1 SP3 SP2 ZIC2 ZFHX2 NFIC IKZF1 GLIS1 CREB1 PRDM10 CYP4F22 PGLYRP2 CYP4F2 CYP4F3 CYP4F11 OR10H4 OR1I1
GH19G015635 0.7 FANTOM5 2.6 -5.3 -5298 0.2 TFAP4 FOXA2 FOXA3 HLF CEBPB MAX ZNF644 RAD21 FOXA1 JUND CYP4F8 HSH2D RAB8A CYP4F3 BRD4 AKAP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP4F3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYP4F3 gene promoter:

Genomic Location for CYP4F3 Gene

Chromosome:
19
Start:
15,640,897 bp from pter
End:
15,662,825 bp from pter
Size:
21,929 bases
Orientation:
Plus strand

Genomic View for CYP4F3 Gene

Genes around CYP4F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP4F3 Gene

Proteins for CYP4F3 Gene

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  • Protein details for CYP4F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08477-CP4F3_HUMAN
    Recommended name:
    Docosahexaenoic acid omega-hydroxylase CYP4F3
    Protein Accession:
    Q08477
    Secondary Accessions:
    • B7Z8Z3
    • O60634
    • Q5U740

    Protein attributes for CYP4F3 Gene

    Size:
    520 amino acids
    Molecular mass:
    59847 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F3 Gene

Protein Expression for CYP4F3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CYP4F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4F3 Gene

Domains & Families for CYP4F3 Gene

Gene Families for CYP4F3 Gene

HGNC:
IUPHAR :

Protein Domains for CYP4F3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP4F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08477

UniProtKB/Swiss-Prot:

CP4F3_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F3: view

Function for CYP4F3 Gene

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Molecular function for CYP4F3 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily IVF,polypeptide 3,59.8kDa,expressed in granulocytes,catalyzing the inactivation of leukotrienne beta 4 with two forms resulting from tissue specific splicing and alternative promoters
UniProtKB/Swiss-Prot CatalyticActivity:
Docosahexaenoate + NADPH + O(2) = 22-hydroxydocosahexaenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by carbon monoxide (CO).
UniProtKB/Swiss-Prot Function:
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
UniProtKB/Swiss-Prot Function:
Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Enzyme Numbers (IUBMB) for CYP4F3 Gene

Gene Ontology (GO) - Molecular Function for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 8486631
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0019825 oxygen binding TAS --
genes like me logo Genes that share ontologies with CYP4F3: view
genes like me logo Genes that share phenotypes with CYP4F3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP4F3

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No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4F3 Gene

Localization for CYP4F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F3 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4F3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
peroxisome 2
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

Pathways & Interactions for CYP4F3 Gene

genes like me logo Genes that share pathways with CYP4F3: view

Pathways by source for CYP4F3 Gene

2 BioSystems pathways for CYP4F3 Gene
2 KEGG pathways for CYP4F3 Gene
1 GeneGo (Thomson Reuters) pathway for CYP4F3 Gene

UniProtKB/Swiss-Prot Q08477-CP4F3_HUMAN

  • Pathway: Lipid metabolism; leukotriene B4 degradation.

Gene Ontology (GO) - Biological Process for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006690 icosanoid metabolic process TAS --
GO:0006691 leukotriene metabolic process TAS --
GO:0036101 leukotriene B4 catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

No data available for SIGNOR curated interactions for CYP4F3 Gene

Drugs & Compounds for CYP4F3 Gene

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(8) Drugs for CYP4F3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon monoxide Approved Pharma 124
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
arachidonic acid Experimental Nutra Activator 30
Leukotriene B4 Pharma BLT1/BLT2 receptor agonist and potent chemotactic factor 0

(11) Additional Compounds for CYP4F3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12(S)-Leukotriene B4
  • 2-Epi-LTB4
  • 5(S),12(S)-Dihydroxyeicosatetraenoate
  • 5(S),12(S)-Dihydroxyeicosatetraenoic acid
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicsatetraenoate
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicsatetraenoic acid
 83709-73-3
12-Keto-tetrahydro-leukotriene B4
  • 12-Keto-10,11,14,15-tetrahydro-LTB4
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoate
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoic acid
18-Hydroxyarachidonic acid
  • (18R)-Hydroxyarachidonate
  • (18R)-Hydroxyarachidonic acid
  • 18(R)-Hydroxyeicosatetraenoate
  • 18(R)-Hydroxyeicosatetraenoic acid
  • 18-HETE
 133268-58-3
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
 79551-86-3
20-Hydroxy-leukotriene B4
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoate
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
 79516-82-8

(4) Tocris Compounds for CYP4F3 Gene

Compound Action Cas Number
Nepicastat hydrochloride Potent and selective dopamine beta-hydroxylase (DBH) inhibitor; orally bioavailable 170151-24-3
pCPA methyl ester hydrochloride Tryptophan hydroxylase inhibitor 14173-40-1
Ro 61-8048 Potent kynurenine 3-monooxygenase (KMO) inhibitor 199666-03-0
UPF 648 Potent kynurenine 3-monooxygenase (KMO) inhibitor 213400-34-1
genes like me logo Genes that share compounds with CYP4F3: view

Transcripts for CYP4F3 Gene

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mRNA/cDNA for CYP4F3 Gene

(7) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4F3 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 3:
Representative Sequences:

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Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for CYP4F3 Gene

GeneLoc Exon Structure for
CYP4F3
ECgene alternative splicing isoforms for
CYP4F3

Expression for CYP4F3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4F3 Gene

mRNA expression in normal human tissues for CYP4F3 Gene
mRNA expression by BioGPS for CYP4F3 GenemRNA expression by GTEx for CYP4F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F3 Gene

This gene is overexpressed in Liver (x26.2), Whole Blood (x10.9), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for CYP4F3 Gene

This gene is overexpressed in Liver (32.9) and Gallbladder (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4F3 Gene



Protein tissue co-expression partners for CYP4F3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP4F3 Gene:

CYP4F3

SOURCE GeneReport for Unigene cluster for CYP4F3 Gene:

Hs.106242

mRNA Expression by UniProt/SwissProt for CYP4F3 Gene:

Q08477-CP4F3_HUMAN
Tissue specificity: Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.

Evidence on tissue expression from TISSUES for CYP4F3 Gene

  • Blood(4.5)
  • Liver(3.8)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with CYP4F3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4F3 Gene

Orthologs for CYP4F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CYP4F3 35
  • 99 (a)
 OneToOne
LOC748117 34
  • 98.85 (n)
dog
(Canis familiaris)
 Mammalia CYP4F3 35
  • 86 (a)
 OneToOne
LOC484867 34
  • 81.33 (n)
cow
(Bos Taurus)
 Mammalia LOC534967 34
  • 82.02 (n)
CYP4F3 35
  • 78 (a)
 ManyToMany
mouse
(Mus musculus)
 Mammalia Cyp4f18 35
  • 80 (a)
 OneToOne
Cyp4f13 34 16
  • 77.78 (n)
rat
(Rattus norvegicus)
 Mammalia Cyp4f6 34
  • 78.72 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 65 (a)
 ManyToMany
-- 35
  • 65 (a)
 ManyToMany
-- 35
  • 62 (a)
 ManyToMany
-- 35
  • 62 (a)
 ManyToMany
-- 35
  • 58 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 73 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 65 (a)
 ManyToMany
-- 35
  • 62 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii cyp4f3 35
  • 49 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cyp4d2 36
  • 38 (a)
Cyp4d14 36
  • 37 (a)
Cyp4s3 36
  • 37 (a)
Cyp4c3 36
  • 36 (a)
Cyp4d1 36
  • 36 (a)
Cyp4d8 36
  • 36 (a)
Cyp4g15 36
  • 35 (a)
Cyp4p1 36
  • 35 (a)
Cyp4p3 36
  • 35 (a)
Cyp4d20 36
  • 34 (a)
Cyp312a1 36
  • 33 (a)
Cyp4ac1 36
  • 33 (a)
Cyp4ac3 36
  • 33 (a)
Cyp4ae1 36
  • 33 (a)
Cyp4e2 36
  • 33 (a)
Cyp4e3 36
  • 33 (a)
Cyp4p2 36
  • 33 (a)
Cyp4ac2 36
  • 32 (a)
Cyp4d21 36
  • 32 (a)
Cyp4e1 36
  • 32 (a)
Cyp311a1 36
  • 31 (a)
Cyp4aa1 36
  • 30 (a)
Cyp4ad1 36
  • 30 (a)
Cyp313a3 36
  • 27 (a)
Cyp313a4 36
  • 26 (a)
Cyp313b1 36
  • 26 (a)
Cyp4g1 36
  • 26 (a)
worm
(Caenorhabditis elegans)
 Secernentea F01D5.9 36
  • 36 (a)
Y17G9B.3 36
  • 36 (a)
Y5H2B.5 36
  • 36 (a)
B0331.1 36
  • 35 (a)
Y38C9B.1 36
  • 34 (a)
Y80D3A.5 36
  • 34 (a)
F28G4.1 36
  • 33 (a)
C26F1.2 36
  • 32 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 43 (a)
 ManyToMany
-- 35
  • 42 (a)
 ManyToMany
-- 35
  • 42 (a)
 ManyToMany
CSA.8060 35
  • 41 (a)
 ManyToMany
-- 35
  • 40 (a)
 ManyToMany
CSA.3998 35
  • 40 (a)
 ManyToMany
-- 35
  • 39 (a)
 ManyToMany
-- 35
  • 38 (a)
 ManyToMany
-- 35
  • 38 (a)
 ManyToMany
-- 35
  • 37 (a)
 ManyToMany
-- 35
  • 37 (a)
 ManyToMany
-- 35
  • 37 (a)
 ManyToMany
CSA.6060 35
  • 37 (a)
 ManyToMany
-- 35
  • 32 (a)
 ManyToMany
-- 35
  • 32 (a)
 ManyToMany
Species where no ortholog for CYP4F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F3 Gene

ENSEMBL:
Gene Tree for CYP4F3 (if available)
TreeFam:
Gene Tree for CYP4F3 (if available)

Paralogs for CYP4F3 Gene

Paralogs for CYP4F3 Gene

(14) SIMAP similar genes for CYP4F3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CYP4F3 Gene

genes like me logo Genes that share paralogs with CYP4F3: view

Variants for CYP4F3 Gene

Sequence variations from dbSNP and Humsavar for CYP4F3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs483352698 Uncertain significance 15,650,089(+) GCGGC(A/G)CCGCA reference, missense
rs1000128213 -- 15,650,587(+) GTATG(A/T)CTTTG intron-variant
rs1000149432 -- 15,643,889(+) GACGG(A/C)CCCTG intron-variant, upstream-variant-2KB
rs1000241751 -- 15,645,724(+) ATTCA(C/T)AGCTC intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs1000384642 -- 15,640,216(+) CATCC(A/G)TTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYP4F3 Gene

Variant ID Type Subtype PubMed ID
dgv3443n100 CNV gain 25217958
dgv3445n100 CNV gain 25217958
dgv627e199 CNV deletion 23128226
esv1597130 CNV insertion 17803354
esv2269626 CNV deletion 18987734
esv22910 CNV loss 19812545
esv2477444 CNV deletion 19546169
esv2674388 CNV deletion 23128226
esv2718235 CNV deletion 23290073
esv2718237 CNV deletion 23290073
esv3556089 CNV deletion 23714750
esv3643775 CNV loss 21293372
nsv1064684 CNV gain 25217958
nsv1066963 CNV gain 25217958
nsv1071160 CNV deletion 25765185
nsv1131406 CNV deletion 24896259
nsv470128 CNV gain 18288195
nsv578718 CNV gain 21841781
nsv954612 CNV deletion 24416366
nsv963014 CNV duplication 23825009
nsv9670 CNV loss 18304495

Variation tolerance for CYP4F3 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4F3 Gene

Human Gene Mutation Database (HGMD)
CYP4F3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F3 Gene

Disorders for CYP4F3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP4F3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 6
  • ibd6
ascariasis
  • ascariasis - roundworm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP4F3

Genetic Association Database (GAD)
CYP4F3
Human Genome Epidemiology (HuGE) Navigator
CYP4F3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F3
genes like me logo Genes that share disorders with CYP4F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4F3 Gene

Publications for CYP4F3 Gene

  1. Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. (PMID: 9539102) Kikuta Y. … Kusunose M. (DNA Cell Biol. 1998) 2 3 4 22 64
  2. Alternative splicing determines the function of CYP4F3 by switching substrate specificity. (PMID: 11461919) Christmas P. … Soberman R.J. (J. Biol. Chem. 2001) 3 4 22 64
  3. Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. (PMID: 10409674) Christmas P. … Soberman R.J. (J. Biol. Chem. 1999) 3 4 22 64
  4. A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega- hydroxylase. (PMID: 8486631) Kikuta Y. … Kusunose M. (J. Biol. Chem. 1993) 2 3 4 64
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64

Products for CYP4F3 Gene

Sources for CYP4F3 Gene

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