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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP4F22 Gene

protein-coding   GIFtS: 55
GCID: GC19P015619

Cytochrome P450, Family 4, Subfamily F, Polypeptide 22

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 4, Subfamily F, Polypeptide 221 2     Cytochrome P450 4F222
LI32 5     Cytochrome P450, Family 2, Subfamily E, Polypeptide 2 Homolog2
ARCI52     EC 1.14.14.-3
INLNE2     

External Ids:    HGNC: 268201   Entrez Gene: 1264102   Ensembl: ENSG000001719547   OMIM: 6114955   UniProtKB: Q6NT553   

Export aliases for CYP4F22 gene to outside databases

Previous GC identifers: GC19P015484 GC19P015187


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP4F22 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme
thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis
lamellar type 3. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4F22 Gene: 
CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) is a protein-coding gene. Diseases associated with CYP4F22 include spinal cancer, and spinal meningioma, and among its related super-pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is TBXAS1.

Gene Wiki entry for CYP4F22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP4F22 gene promoter:
         TBP   p53   POU2F1   AML1a   POU2F1a   ATF-2   c-Jun   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4F22 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP4F22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

CYP4F22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4F22 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015619:  view genomic region     (about GC identifiers)

Start:
15,619,304 bp from pter      End:
15,663,128 bp from pter
Size:
43,825 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP4FN_HUMAN, Q6NT55 (See protein sequence)
Recommended Name: Cytochrome P450 4F22  
Size: 531 amino acids; 61958 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome
membrane; Peripheral membrane protein (By similarity)
Secondary accessions: Q8N8H4

Explore the universe of human proteins at neXtProt for CYP4F22: NX_Q6NT55

Explore proteomics data for CYP4F22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NT55

  • CYP4F22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP4F22 Protein Expression
    REFSEQ proteins: NP_775754.2  
    ENSEMBL proteins: 
     ENSP00000269703   ENSP00000469866  
    Reactome Protein details: Q6NT55
    Human Recombinant Protein Products for CYP4F22: 
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    Cloud-Clone Corp. Proteins for CYP4F22 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--

    CYP4F22 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4F22 
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q6NT55

    ProtoNet protein and cluster: Q6NT55

    UniProtKB/Swiss-Prot: CP4FN_HUMAN, Q6NT55
    Similarity: Belongs to the cytochrome P450 family


    CYP4F22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 1.14.14.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
    GO:0020037heme binding IEA--
         
    CYP4F22 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCYP4F22 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP4F22 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.41
    Arachidonic acid metabolism0.44
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    5Fatty acids
    Fatty acids0.50
    Miscellaneous substrates0.42
    Eicosanoids0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP4F22
        cytochrome P450
    metapathway biotransformation


    5/10        Reactome Pathways for CYP4F22 (see all 10)
        Cytochrome P450 - arranged by substrate type
    Miscellaneous substrates
    Eicosanoids
    Fatty acids
    Metabolism


    2         Kegg Pathways  (Kegg details for CYP4F22):
        Arachidonic acid metabolism
    Metabolic pathways


    CYP4F22 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4F22

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CYP4F22 (ENSP000002697034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    CYP4F22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP4F22 (CP4FN)

    1 HMDB Compound for CYP4F22    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    Search CenterWatch for drugs/clinical trials and news about CYP4F22 / CP4FN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP4F22 gene: 
    NM_173483.3  

    Unigene Cluster for CYP4F22:

    Cytochrome P450, family 4, subfamily F, polypeptide 22
    Hs.156452  [show with all ESTs]
    Unigene Representative Sequence: NM_173483
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269703(uc002nbh.4) ENST00000601005
    miRNA
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    hsa-miR-3184 hsa-miR-663 hsa-miR-545 hsa-miR-1908 hsa-miR-423-5p hsa-miR-744 hsa-miR-3180-3p hsa-miR-3202
    SwitchGear 3'UTR luciferase reporter plasmidCYP4F22 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F22

    Additional mRNA sequence: 

    AK096820.1 BC069351.1 BC093894.1 BC093896.1 

    1 DOTS entry:

    DT.70104375 

    9 AceView cDNA sequences:

    BG675134 AI341068 BC069351 AI274139 NM_173483 AW025687 AK096820 BG674500 
    BF770977 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP4F22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATGAGGG
    CYP4F22 Expression
    About this image


    See CYP4F22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP4F22

    SOURCE GeneReport for Unigene cluster: Hs.156452
        SABiosciences Custom PCR Arrays for CYP4F22
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4F22 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4f391 , 5 cytochrome P450, family 4, subfamily f, polypeptide more1, 5 82.99(n)1
    86.82(a)1
      17 (17.59 cM)5
    3209971  NM_177307.31  NP_796281.11 
     324684625 
    chicken
    (Gallus gallus)
    Aves LOC1008592771 cytochrome P450 4F22-like 69.77(n)
    66.45(a)
      100859277  XM_003644029.1  XP_003644077.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    68(a)
    63(a)
    many ↔ many
    many ↔ many
    2(79856458-79966876)
    AAWZ02039718(3621-5749)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB114053.12   -- 74.53(n)    AB114053.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4f36
    cytochrome P450, family 4, subfamily F, polypeptid...
    47(a)
    1 → many
    12(49851155-49871433)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp4d26
    Cyp4s36
    (see all 17)
    Cyp4s3
    (see all 17)
    31(a)
    31(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    X(2070924-2072761)
    X(15007335-15010572)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP735A21 cytokinin trans-hydroxylase 41.56(n)
    30.08(a)
      843031  NM_105381.4  NP_176882.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04033001 hypothetical protein 46.19(n)
    30.48(a)
      9269428  NM_001188894.1  NP_001175823.1 


    ENSEMBL Gene Tree for CYP4F22 (if available)
    TreeFam Gene Tree for CYP4F22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP4F22 gene
    TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    13 SIMAP similar genes for CYP4F22 using alignment to 1 protein entry:     CP4FN_HUMAN:
    CYP4F2    CYP4F3    CYP4F11    CYP4F12    DKFZp761K058    CYP4F8
    CYP4B1    CYP4A11    CYP4Z1    CYP4Z2P    CYP4X1    CYP4A22
    CYP4V2

    CYP4F22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1148 SNPs in CYP4F22 are shown (see all 1148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0374444
    Ichthyosis, congenital, autosomal recessive 5 (ARCI5)4--see VAR_0374442 H Y mis40--------
    VAR_0374424
    Ichthyosis, congenital, autosomal recessive 5 (ARCI5)4--see VAR_0374422 R H mis40--------
    VAR_0374454
    Ichthyosis, congenital, autosomal recessive 5 (ARCI5)4--see VAR_0374452 H D mis40--------
    VAR_0374414
    Ichthyosis, congenital, autosomal recessive 5 (ARCI5)4--see VAR_0374412 F L mis40--------
    VAR_0374434
    Ichthyosis, congenital, autosomal recessive 5 (ARCI5)4--see VAR_0374432 R W mis40--------
    rs1460660931,2
    C--15191569(+) GCTTT-/TCTCTCT 1 -- int10--------
    rs3717220461,2
    C--15197038(+) AAATA-/AAAAAA 1 -- int10--------
    rs344092971,2
    C--15203391(+) GAGAG-/AA    
       
    /AGAA
    AGAAA
    1 -- int10--------
    rs345727531,2
    C--15207281(+) GGTGG-/TCTTCTTC 1 -- int10--------
    rs605496801,2
    C--15207844(+) TTTTT-/T/TT  
            
    GAGGT
    1 -- int11CSA 2

    HapMap Linkage Disequilibrium report for CYP4F22 (15619304 - 15663128 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP4F22:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1000418CNV Deletion20482838
    dgv3746n71CNV Loss21882294
    nsv911139CNV Gain21882294
    nsv911138CNV Gain21882294


    Human Gene Mutation Database (HGMD): CYP4F22
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4F22
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4F22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611495   
    OMIM disorders: 604777  
    UniProtKB/Swiss-Prot: CP4FN_HUMAN, Q6NT55
  • Ichthyosis, congenital, autosomal recessive 5 (ARCI5) [MIM:604777]: A form of autosomal recessive
    congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the
    epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar
    ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within
    the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often
    associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the
    entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on
    an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 14 diseases for CYP4F22:    About MalaCards
    spinal cancer    spinal meningioma    cyp4f22-related autosomal recessive congenital ichthyosis    ichthyosis lamellar 3
    autosomal recessive congenital ichthyosis    ectropion    typhus    scrub typhus
    ichthyosis    congenital ichthyosiform erythroderma    cytochrome p450    alopecia
    meningioma    tuberculosis

    3 diseases from the University of Copenhagen DISEASES database for CYP4F22:
    Congenital ichthyosiform erythroderma     Spinal meningioma     Scrub typhus

    CYP4F22 for disorders           About GeneDecksing

    GeneTests: CYP4F22
    GeneReviews: CYP4F22
    Genetic Association Database (GAD): CYP4F22

    Export disorders for CYP4F22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP4F22 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CYP4F22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3. (PubMed id 16436457)1, 2, 3 Lefevre C.... Fischer J. (2006)
    2. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)4 Wang J....Platt A. (2012)
    3. CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development. (PubMed id 22209317)1 Sasaki K....Shimizu H. (2012)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. (PubMed id 21540472)1 Kelly E.J....Rettie A.E. (2011)
    6. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. (PubMed id 18245815)1 Elias P.M....Schmuth M. (2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126410 HGNC: 26820 AceView: FLJ39501 Ensembl:ENSG00000171954 euGenes: HUgn126410
    ECgene: CYP4F22 Kegg: 126410 H-InvDB: CYP4F22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP4F22 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CYP4F22

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP4F22 gene:
    Search GeneIP for patents involving CYP4F22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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