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Aliases for CYP4F22 Gene

Aliases for CYP4F22 Gene

  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 22 2 3
  • ARCI5 3 6
  • LI3 3 6
  • Cytochrome P450, Family 2, Subfamily E, Polypeptide 2 Homolog 3
  • Cytochrome P450 4F22 3
  • EC 1.14.14.- 4
  • INLNE 3

External Ids for CYP4F22 Gene

Previous GeneCards Identifiers for CYP4F22 Gene

  • GC19P015619
  • GC19P015187

Summaries for CYP4F22 Gene

Entrez Gene Summary for CYP4F22 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F22 Gene

CYP4F22 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 22) is a Protein Coding gene. Diseases associated with CYP4F22 include ichthyosis, congenital, autosomal recessive 5 and cyp4f22-related autosomal recessive congenital ichthyosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

Gene Wiki entry for CYP4F22 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F22 Gene

Genomics for CYP4F22 Gene

Regulatory Elements for CYP4F22 Gene

Genomic Location for CYP4F22 Gene

15,508,493 bp from pter
15,552,317 bp from pter
43,825 bases
Plus strand

Genomic View for CYP4F22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4F22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F22 Gene

Proteins for CYP4F22 Gene

  • Protein details for CYP4F22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 4F22
    Protein Accession:
    Secondary Accessions:
    • Q8N8H4

    Protein attributes for CYP4F22 Gene

    531 amino acids
    Molecular mass:
    61958 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4F22 Gene

Proteomics data for CYP4F22 Gene at MOPED

Post-translational modifications for CYP4F22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CYP4F22

No data available for DME Specific Peptides for CYP4F22 Gene

Domains for CYP4F22 Gene

Gene Families for CYP4F22 Gene

Protein Domains for CYP4F22 Gene

Suggested Antigen Peptide Sequences for CYP4F22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F22: view

Function for CYP4F22 Gene

Enzyme Numbers (IUBMB) for CYP4F22 Gene

Gene Ontology (GO) - Molecular Function for CYP4F22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP4F22: view

Animal Model Products

CRISPR Products

miRNA for CYP4F22 Gene

miRTarBase miRNAs that target CYP4F22

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F22

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F22 Gene

Localization for CYP4F22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F22 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CYP4F22 Gene COMPARTMENTS Subcellular localization image for CYP4F22 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYP4F22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CYP4F22: view

Pathways for CYP4F22 Gene

genes like me logo Genes that share pathways with CYP4F22: view

Interacting Proteins for CYP4F22 Gene

Gene Ontology (GO) - Biological Process for CYP4F22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006690 icosanoid metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F22: view

Drugs for CYP4F22 Gene

(10) HMDB Compounds for CYP4F22 Gene

Compound Synonyms Cas Number PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
20-Hydroxy-leukotriene B4
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoate
Arachidonic acid
  • (all-Z)-5,8,11,14-Eicosatetraenoate
  • (protoporphyrinato)iron
Hydrogen Ion
  • Hydrogen cation
genes like me logo Genes that share compounds with CYP4F22: view

Transcripts for CYP4F22 Gene

mRNA/cDNA for CYP4F22 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4F22 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F22 Gene

No ASD Table

Relevant External Links for CYP4F22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP4F22 Gene

mRNA expression in normal human tissues for CYP4F22 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4F22 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (16.0), Skin - Not Sun Exposed (Suprapubic) (12.3), Vagina (5.5), and Esophagus - Mucosa (4.8).

Protein differential expression in normal tissues for CYP4F22 Gene

This gene is overexpressed in Cervix (38.1) and Urine (28.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP4F22 Gene

SOURCE GeneReport for Unigene cluster for CYP4F22 Gene Hs.156452

genes like me logo Genes that share expressions with CYP4F22: view

Expression partners for CYP4F22 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CYP4F22 Gene

Orthologs for CYP4F22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100301224 35
  • 88.7 (n)
  • 93.03 (a)
CYP4F22 36
  • 93 (a)
(Canis familiaris)
Mammalia CYP4F22 35
  • 88.32 (n)
  • 91.53 (a)
CYP4F22 36
  • 92 (a)
(Mus musculus)
Mammalia Cyp4f39 35
  • 82.99 (n)
  • 86.82 (a)
Cyp4f39 16
Cyp4f39 36
  • 86 (a)
(Pan troglodytes)
Mammalia LOC455798 35
  • 99.25 (n)
  • 99.06 (a)
CYP4F22 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cyp4f39 35
  • 82.93 (n)
  • 87.01 (a)
(Monodelphis domestica)
Mammalia CYP4F22 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CYP4F22 36
  • 79 (a)
(Gallus gallus)
Aves -- 36
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
-- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp4f22 35
  • 65.27 (n)
  • 64.26 (a)
Str.8475 35
(Danio rerio)
Actinopterygii cyp4f3 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP735A1 35
  • 41.99 (n)
  • 31.37 (a)
(Oryza sativa)
Liliopsida Os09g0403300 35
  • 46.92 (n)
  • 31.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2108 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
-- 36
  • 38 (a)
-- 36
  • 38 (a)
-- 36
  • 37 (a)
-- 36
  • 41 (a)
-- 36
  • 31 (a)
-- 36
  • 38 (a)
-- 36
  • 36 (a)
-- 36
  • 37 (a)
-- 36
  • 40 (a)
-- 36
  • 42 (a)
-- 36
  • 31 (a)
CSA.3998 36
  • 42 (a)
CSA.6060 36
  • 38 (a)
CSA.8060 36
  • 38 (a)
Species with no ortholog for CYP4F22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP4F22 Gene

Gene Tree for CYP4F22 (if available)
Gene Tree for CYP4F22 (if available)

Paralogs for CYP4F22 Gene

(13) SIMAP similar genes for CYP4F22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP4F22: view

Variants for CYP4F22 Gene

Sequence variations from dbSNP and Humsavar for CYP4F22 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892143 -- 15,534,809(+) aggag(C/T)ttgcc intron-variant
rs892144 -- 15,545,395(+) gtaat(C/T)ccagc intron-variant
rs939501 -- 15,534,958(+) agcag(A/G)aactg intron-variant
rs992914 -- 15,547,228(+) CTATG(C/T)TGGCC intron-variant
rs992915 -- 15,547,277(+) TCTCA(G/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4F22 Gene

Variant ID Type Subtype PubMed ID
dgv3746n71 CNV Loss 21882294
nsv911138 CNV Gain 21882294
nsv911139 CNV Gain 21882294
esv1000418 CNV Deletion 20482838

Relevant External Links for CYP4F22 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F22 Gene

Disorders for CYP4F22 Gene

(1) OMIM Diseases for CYP4F22 Gene (611495)


  • Ichthyosis, congenital, autosomal recessive 5 (ARCI5) [MIM:604777]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO:0000269 PubMed:16436457}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CYP4F22 Gene

Relevant External Links for CYP4F22

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CYP4F22: view

No data available for Novoseek inferred disease relationships and Genatlas for CYP4F22 Gene

Publications for CYP4F22 Gene

  1. Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3. (PMID: 16436457) Lefevre C. … Fischer J. (Hum. Mol. Genet. 2006) 2 3 4
  2. Autosomal Recessive Congenital Ichthyosis (PMID: 20301593) Pagon R.A. … Stephens K. ( 1993) 3
  3. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. (PMID: 21540472) Kelly E.J. … Rettie A.E. (Mol. Interv. 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development. (PMID: 22209317) Sasaki K. … Shimizu H. (J. Dermatol. Sci. 2012) 3

Products for CYP4F22 Gene

Sources for CYP4F22 Gene

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