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CYP4F2 Gene

protein-coding GIFtS: 61

GC19M015988

cytochrome P450, family 4, subfamily F, polypeptide 2
(Previous names: cytochrome P450, subfamily IVF, polypeptide 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
cytochrome P450, family 4, subfamily F, polypeptide 2¹ ²		leukotriene-B4 20-monooxygenase²
cytochrome P450, subfamily IVF, polypeptide 2¹ ²		leukotriene-B(4) omega-hydroxylase 1²
Cytochrome P450 4F2² ³		CPF2²
Leukotriene-B(4) 20-monooxygenase 1² ³		leukotriene B4 omega-hydroxylase²
Cytochrome P450-LTB-omega² ³		EC 1.14.13.30³
CYPIVF2² ³

External Ids:	HGNC: 2645¹	Entrez Gene: 8529²	Ensembl: ENSG00000186115⁷	UniProtKB: P78329³

Search outside databases for aliases for CYP4F2 gene

Previous GC identifers: GC19M016474 GC19M015725 GC19M015849

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4F2:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and

degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes

on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. (provided by RefSeq)

UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP4F2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP4F2 gene upstream (promoter) region

:
FOXO3a FOXO3b FOXO1a Pbx1a XBP-1 GATA-1 MRF-2 Tal-1beta ITF-2 NF-kappaB1

Epigenetics:

Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP4F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19pter-p13.11 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19pter-p13.11

CYP4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M015988: view genomic region (about GC identifiers)

Start:	15,988,834 bp from pter
End:	16,008,885 bp from pter
Size:	20,052 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.9 NT_011295.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329 (See protein sequence)

Recommended Name: Leukotriene-B(4) omega-hydroxylase 1

Size: 520 amino acids; 59853 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Secondary accessions: A8K425 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8

REFSEQ proteins: NP_001073.3

ENSEMBL proteins:

ENSP00000011989 ENSP00000221700 ENSP00000376588

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CYP4F2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abnova for HuPro® and/or Recombinant Proteins
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Browse Sino Biological Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	EXP	9799565
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--
GO:0019898	extrinsic to membrane	--	--

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CYP4F2 for ontologies About GeneDecksing

Antibodies for CYP4F2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CYP4F2
	Browse R&D Systems for Antibodies
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Browse Origene Antibodies
	Browse antibodies at Epitomics

Assays for CYP4F2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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CYP4F2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR017973 Cyt_P450_C

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P78329

ProtoNet protein and cluster: P78329

1 Blocks protein family: IPB002402 Group II E-class P450 signature

UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329

Similarity: Belongs to the cytochrome P450 family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP4F2)
		Origene 29mer shRNA kits in GFP-retroviral vector: CYP4F2 Origene shRNA RFP: CYP4F2 Origene basic RS shRNA: CYP4F2
		Applied Biosystems Silencer® siRNAs for CYP4F2
		Sigma-Aldrich siRNA Panels and siRNA for CYP4F2 Sigma-Aldrich shRNA for CYP4F2 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: CYP4F2 Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP4F2 Origene untagged cDNA clones in CMV expression vector: CYP4F2
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Catalytic activity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) =

(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O

Enzyme Number (IUBMB): EC 1.14.13.30

Genatlas biochemistry entry for CYP4F2:

leukotriene B4 omega-hydroxylase,involved in the degradation of LTB4,a potent mediator of inflammation

5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	TAS	8026587
GO:0005506	iron ion binding	--	--
GO:0005515	protein binding	IPI	17474147
GO:0008393	fatty acid (omega-1)-hydroxylase activity	IDA	18433732
GO:0009055	electron carrier activity	IEA	--

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CYP4F2 for ontologies About GeneDecksing

Animal Models: 1 MGI phenotypic allele for Cyp4f13 (no phenotypes)

CYP4F2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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CYP4F2 for pathways About GeneDecksing

1 Millipore Pathway for CYP4F2

HETE and HPETE biosynthesis and metabolism

1 Sigma-Aldrich "Your Favorite Gene" Pathway for CYP4F2 (Your Favorite Gene powered by Ingenuity)

Arachidonic Acid Metabolism

2 Kegg Pathways (Kegg details for CYP4F2):

	hsa00590 Arachidonic acid metabolism
	hsa01100 Metabolic pathways

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP4F2

5/6 Interacting proteins for CYP4F2 (ENSP00000221700³ P78329^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCK1	P16333¹^,²	EBI-1752413,EBI-389883 MINT-7248634 MINT-7249738 EBI-1752413,EBI-389883 MINT-7248634 MINT-7249738
ABL1	P00519¹^,²	EBI-1752413,EBI-375543 MINT-7243834 EBI-1752413,EBI-375543 MINT-7243834
FYN	P06241¹^,²	EBI-1752413,EBI-515315 MINT-7246702 EBI-1752413,EBI-515315 MINT-7246702
SRC	P12931¹^,²	EBI-1752413,EBI-621482 MINT-7245766 EBI-1752413,EBI-621482 MINT-7245766
GRB2	P62993¹	EBI-1752413,EBI-401755

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4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000038	very-long-chain fatty acid metabolic process	IDA	18433732
GO:0001676	long-chain fatty acid metabolic process	IDA	18433732
GO:0006691	leukotriene metabolic process	TAS	8026587
GO:0055114	oxidation reduction	IEA	--

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CYP4F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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CYP4F2 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for CYP4F2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CYP4F2
10/22 Novoseek chemical compound relationships for CYP4F2 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
20-hydroxyeicosatetraenoic acid	71.14	24	19279555 (6), 9618440 (5), 18391101 (4), 18235092 (3) (see all 8)
warfarin	24.60	16	19207028 (4), 18250228 (3), 19794411 (2), 19300499 (2) (see all 8)
vitamin k	14.76	9	19297519 (7), 20072124 (1), 18998206 (1)
leukotriene b4	13.82	9	10492403 (2), 18787519 (1), 17341693 (1), 16835590 (1) (see all 8)
arachidonic acid	12.62	12	9618440 (4), 19279555 (1), 18971550 (1), 18787519 (1) (see all 9)
lovastatin	4.34	3	17142457 (3)
trioxilin a3	3.70	1	16436457 (1)
12-hydroxydodecanoic acid	3.38	1	10860554 (1)
db289	3.31	1	17709372 (1)
cadmium	2.92	4	15994032 (4)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP4F2)
		Applied Biosystems Silencer® siRNAs: NM_001082
		Origene 29mer shRNA kits in GFP-retroviral vector: CYP4F2 Origene shRNA RFP: CYP4F2 Origene basic RS shRNA: CYP4F2
		Sigma-Aldrich siRNA Panels and siRNA for CYP4F2 Sigma-Aldrich shRNA for CYP4F2 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate CYP4F2:

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_001082

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: CYP4F2
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP4F2
Origene untagged cDNA clones in CMV expression vector: CYP4F2

Primers:		Origene genome-wide validated SYBR primer pairs: CYP4F2
		SABiosciences RT2 qPCR Primer Assay for CYP4F2: PPH01218A

REFSEQ mRNAs for CYP4F2 gene:

NM_001082.3

Additional cDNA sequence:

AK290790.1 AK296200.1 AK300961.1 AK313705.1 BC067437.1 BC067438.1 BC067439.1 BC067440.1

D26480.1 U02388.2

4 DOTS entries:

DT.101958587 DT.121496202 DT.452202 DT.95372012

24/61 AceView cDNA sequences (see all 61 ):

AA377259 CB157546 AV655184 BC067439 BE552106 CB161237 NM_001082 AW118600

AI953391 AA377260 AI364951 AW771881 CF271895 CF271894 CK032817 CB162371

CK130195 BE463551 BC067437 CB157046 BI763623 CA423188 CF271900 CK032819

highest scoring ESTs for CYP4F2:

U02388 BC067437 BC067438 BC067439 BC067440 BI763623 CD610505 D26480 AA377259 AA377260

Unigene Cluster for CYP4F2:

Cytochrome P450, family 4, subfamily F, polypeptide 2

Hs.558423 [show with all ESTs]

Unigene Representative Sequence: U02388

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F2

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11
SP1:
SP2:																					-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for CYP4F2

3 Ensembl transcripts including schematic representations:

ENST00000011989 ENST00000221700 ENST00000392846

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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CYP4F2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP4F2

¹ / ² / ³

3 probe-sets matching CYP4F2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1350_at²^{, 3}	U95-A	1	0.81	1.00	1.00	1.00	U02388	1.00	1.00	1.00	1
210452_x_at²^{, 3}	U133-A	2	1.00	0.82	--	--	D26480	0.80	1.00	0.91	1
210452_x_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--

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CYP4F2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.558423

Expression variation in blood from EXPOLDB for CYP4F2

UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329

Tissue specificity: Liver

Primers:		Origene genome-wide validated SYBR primer pairs: CYP4F2
		SABiosciences RT2 qPCR Primer Assay for CYP4F2: PPH01218A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CYP4F2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC484867¹	--	similar to Cytochrome P450 4F6 (CYPIVF6)	80.36(n) 76.74(a)	484867 XM_541983.2 XP_541983.2
chimpanzee (Pan troglodytes)	LOC748531¹	--	similar to cytochrome P450, family 4, subfamily F, more	98.33(n) 98.27(a)	748531 XM_001172522.1 XP_001172522.1
cow (Bos taurus)	CYP4F3¹	--	cytochrome P450, family 4, subfamily F, polypeptide more	81.7(n) 79(a)	534967 NM_001046391.1 NP_001039856.1
rat (Rattus norvegicus)	Cyp4f6¹	--	cytochrome P450 4F6	77.63(n) 73.46(a)	266689 NM_153318.1 NP_695230.1
mouse (Mus musculus)	Cyp4f13^{1, 5}	17⁵	cytochrome P450, family 4, subfamily f, polypeptide more^{1, 5}	77.07(n)¹ 73.03(a)¹	170716¹ NM_130882.1¹ NP_570952.1¹ AF233643⁵ AK085008⁵ (see all 8)

About this table Species with no ortholog for CYP4F2

ENSEMBL Gene Tree for CYP4F2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CYP4F2 gene

CYP4F22² CYP4F11² CYP4F3² CYP4F8² CYP46A1² LOC388514² CYP4B1² CYP3A5²

CYP4X1² TBXAS1² CYP3A43² CYP3A4² CYP3A7² CYP4V2² CYP4A22² CYP4A11²

CYP4Z1² CYP4F12²

CYP4F2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/375 NCBI SNPs in CYP4F2 are shown (see all 375 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3093203^1,2	C,F,A,H	15989184(-)	`ttataC/Tgaaat`	1	--	ut3¹ ese³		5	NS NA	100
--	rs1126433^1,2	C,F,A,H	15989405(-)	`atggcG/Agccct`	1	--	ut3¹ ese³		3	NS MN	274
--	rs3093089^1,2	C,F,A,H	15580569(-)	`attcaT/Ccctat`	1	--	ng5¹		12	NS EA NA WA	712
--	rs3093204^1,2	C,F,H	15989167(-)	`aacagG/Accaat`	1	--	ut3¹ ese³		2	NS	94
--	rs1272^1,2	C,F,H	15989040(-)	`agataG/Ctgacg`	1	--	ut3¹		13	NS MN EA NA	800
--	rs3093201^1,2	C,F,H	15989454(-)	`ataatT/Cgagac`	1	--	ut3¹		2	NS	92
--	rs3093081^1,2	C,F,H	15582072(-)	`ctcatT/Cgggga`	1	--	ng5¹		3	NS NA	64
--	rs3093209^1,2	C,F,A	15559835(-)	`ggtcaC/Gtcagt`	1	--	ng3¹		5	NS NA EA	248
	rs3093153^1,2	C,F,H	16001215(-)	`AGAGGA/C/G/T TAGTG`	4	D A G V	mis¹ ref¹ ese³		31	NS NA EA MN WA	3938
--	rs3093085^1,2	C,F	15581184(-)	`GCAAAT/GCAGAC`	1	--	ng5¹		2	NS	88

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HapMap Linkage Disequilibrium images for CYP4F2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYP4F2
2 Indels: 45729 26199

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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CYP4F2 for disorders About GeneDecksing

OMIM: 604426

10/12 Novoseek disease relationships for CYP4F2 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cerebral infarction	3.73	3	18787519 (3)
ischemic stroke	2.95	3	20130494 (3)
essential hypertension	2.74	3	18971550 (3)
infarction; myocardial	2.45	5	19957603 (3), 19097922 (2)
dysfunction; renal tubular	2.24	1	15994032 (1)
hypertension	1.87	6	18235092 (3), 19279555 (2), 15994032 (1)
hemorrhagic stroke	1.57	1	20130494 (1)
hypercholesterolemia	0.82	1	17142457 (1)
inflammation	0.73	3	18433732 (1), 16835590 (1), 10492403 (1)
celiac disease	0.62	1	18433732 (1)

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Locus Specific Mutation Databases: CYP4F2
Human Gene Mutation Database: CYP4F2
Human Genome Epidemiology Navigator: CYP4F2 (26 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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31/60 PubMed articles for CYP4F2 gene (see all 60 ):

Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver. (PubMed id 8026587)^{2, 3, 4} Kikuta Y....Kusunose M. (1994)
Expression and molecular cloning of human liver leukotriene B4 omega- hydroxylase (CYP4F2) gene. (PubMed id 10492403)^{1, 3, 4} Kikuta Y.... Kusunose M. (1999)
Promoter activity and regulation of the CYP4F2 leukotriene B4 omega hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells. (PubMed id 10860554)^{1, 3, 4} Zhang X.... Hardwick J.P. (2000)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. (PubMed id 8424651)^{2, 3} Chen L. and Hardwick J.P. (1993)
CYP4F2 Is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. (PubMed id 19297519)^{1, 3} McDonald M.G....Rettie A.E. (2009)
Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. (PubMed id 17142457)^{1, 3} Hsu M.H....Johnson E.F. (2007)
Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. (PubMed id 9618440)^{1, 3} Powell P.K....Lasker J.M. (1998)
CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. (PubMed id 19207028)^{1, 3} Borgiani P....Novelli G. (2009)
A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. (PubMed id 18391101)^{1, 3} Ward N.C....Croft K.D. (2008)
Functional polymorphism in human CYP4F2 decreases 20-HETE production. (PubMed id 17341693)^{1, 3} Stec D.E....Rieder M.J. (2007)
CYP4F2 genetic variant alters required warfarin dose. (PubMed id 18250228)^{1, 3} Caldwell M.D....Burmester J.K. (2008)
A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. (PubMed id 18787519)^{1, 3} Fu Z....Ma Y. (2008)
Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects. (PubMed id 18971550)^{1, 3} Fu Z....Ma Y. (2008)
Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells. (PubMed id 11162441)^{1, 3} Zhang X. and Hardwick J.P. (2000)
[Association on the haplotypes of CYP4F2 gene and myo cardial infarction] (PubMed id 19957603)^{1, 3} Huang D....Ma Y.T. (year=2009;month=Jul;day=)
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. (PubMed id 19300499)^{1, 3} Takeuchi F....Deloukas P. (2009)
A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men. (PubMed id 19097922)^{1, 3} Fu Z....Hinohara S. (2009)
Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) a re predictor variables for warfarin response in very elderly, frail inpatients. (PubMed id 19794411)^{1, 3} Pautas E....Siguret V. (year=2010;month=Jan;day=)
Pharmacogenetic relevance of CYP4F2 V433M polymorphism on acenocoumarol therapy. (PubMed id 19270263)³ PAcrez-Andreu V....GonzA!lez-Conejero R. (2009)
Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies. (PubMed id 18662666)³ Hirani V....Lasker J.M. (2008)
The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. (PubMed id 18574070)³ Fava C....Melander O. (2008)
[Correlation analysis and identification of G421C in regulatory region of CYP4F2 gene with essential hypertension] (PubMed id 16733892)³ Liu H....Lu J.Y. (2006)
Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. (PubMed id 10660572)³ Lasker J.M....Powell P.K. (2000)
CYP4F2 gene V433M polymorphism is associated with isc hemic stroke in the male Northern Chinese Han population. (PubMed id 20227456)³ Deng S....Zhiyi H. (year=2010;month=May;day=30)
Effects of CYP4F2 genetic polymorphisms and haplotype s on clinical outcomes in patients initiated on warfarin therapy. (PubMed id 19741565)³ Zhang J.E....Pirmohamed M. (year=2009;month=Oct;day=)
Role of human CYP4F2 in hepatic catabolism of the pro inflammatory agent leukotriene B4. (PubMed id 9799565)³ Jin R....Lasker J.M. (year=1998;month=Nov;day=1)
Impact of CYP4F2 rs2108622 on the stable warfarin dos e in an admixed patient cohort. (PubMed id 20182420)³ Perini J.A....Suarez-Kurtz G. (year=2010;month=Apr;day=)
Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1. (PubMed id 15994032)¹ Baker J.R....Satarug S. (2005)
Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2). (PubMed id 10833273)¹ Kikuta Y....Kusunose M. (2000)

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Entrez Gene: 8529	HGNC: 2645	AceView: CYP4F2	Ensembl:ENSG00000186115	euGenes: HUgn8529
ECgene: CYP4F2	Kegg: 8529	H-InvDB: CYP4F2

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