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CYP4F2 Gene

protein-coding   GIFtS: 67
GCID: GC19M015988

Cytochrome P450, Family 4, Subfamily F, Polypeptide 2

(Previous names: cytochrome P450, subfamily IVF, polypeptide 2)
  See CYP4F2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 4, Subfamily F, Polypeptide 21 2     CPF22
Cytochrome P450, Subfamily IVF, Polypeptide 21 2     Leukotriene B4 Omega-Hydroxylase2
Cytochrome P450 4F22 3     Leukotriene-B(4) Omega-Hydroxylase 12
Cytochrome P450-LTB-Omega2 3     Leukotriene-B4 20-Monooxygenase2
Leukotriene-B(4) 20-Monooxygenase 12 3     EC 1.14.13.303
CYPIVF22 3     

External Ids:    HGNC: 26451   Entrez Gene: 85292   Ensembl: ENSG000001861157   OMIM: 6044265   UniProtKB: P783293   

Export aliases for CYP4F2 gene to outside databases

Previous GC identifers: GC19M016474 GC19M015725 GC19M015849 GC19M015560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4F2 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of
inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of
cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4F2 Gene:
CYP4F2 (cytochrome P450, family 4, subfamily F, polypeptide 2) is a protein-coding gene. Diseases associated with CYP4F2 include warfarin sensitivity. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP4F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4F2 gene promoter:
         p53   HSF1 (long)   Pax-2   Pax-2a   GATA-2   YY1   RORalpha1   FOXO4   HOXA5   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4F2 promoter sequence
   Search Chromatin IP Primers for CYP4F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

CYP4F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4F2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015988:  view genomic region     (about GC identifiers)

Start:
15,988,833 bp from pter      End:
16,008,930 bp from pter
Size:
20,098 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329 (See protein sequence)
Recommended Name: Leukotriene-B(4) omega-hydroxylase 1  
Size: 520 amino acids; 59853 Da
Cofactor: Heme group (By similarity)
Secondary accessions: A8K425 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8

Explore the universe of human proteins at neXtProt for CYP4F2: NX_P78329

Explore proteomics data for CYP4F2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP4F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073.3  
    ENSEMBL proteins: 
     ENSP00000221700   ENSP00000467846   ENSP00000467443   ENSP00000465514   ENSP00000011989  
    Reactome Protein details: P78329

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4F2
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P78329

    ProtoNet protein and cluster: P78329

    1 Blocks protein domain: IPB002402 Group II E-class P450 signature

    UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP4F2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4F2_HUMAN, P78329
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) =
    (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O

         Genatlas biochemistry entry for CYP4F2:
    leukotriene B4 omega-hydroxylase,involved in the degradation of LTB4,a potent mediator of inflammation

         Enzyme Number (IUBMB): EC 1.14.13.301

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI17474147
    GO:0008392arachidonic acid epoxygenase activity IDA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0018685alkane 1-monooxygenase activity IDA18433732
         
    Find genes that share ontologies with CYP4F2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYP4F2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4F2_HUMAN, P78329: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular2
    peroxisome2
    cytoskeleton1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10660572
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016324apical plasma membrane IDA10660572
    GO:0043231intracellular membrane-bounded organelle IDA10660572

    Find genes that share ontologies with CYP4F2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4F2 About    
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    Arachidonic acid metabolism0.40
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.00
    HETE and HPETE biosynthesis and metabolism0.33
    alpha-tocopherol degradation0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Miscellaneous substrates0.00
    cytochrome P4500.74
    Eicosanoids0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42


    Find genes that share SuperPaths with CYP4F2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYP4F2
        HETE and HPETE biosynthesis and metabolism

    3 BioSystems Pathways for CYP4F2
        cytochrome P450
    metapathway biotransformation
    alpha-tocopherol degradation

    5 Reactome Pathways for CYP4F2
        Miscellaneous substrates
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    Fatty acids
    Eicosanoids
    Synthesis of Leukotrienes (LT) and Eoxins (EX)


    2 Kegg Pathways  (Kegg details for CYP4F2):
        Arachidonic acid metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F2: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP4F2 (P783291, 3 ENSP000002217004) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1752413,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA18433732
    GO:0001676long-chain fatty acid metabolic process IDA18433732
    GO:0003091renal water homeostasis IEP10660572
    GO:0003095pressure natriuresis IEP10660572
    GO:0006690icosanoid metabolic process TAS--

    Find genes that share ontologies with CYP4F2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4F2 (CP4F2)

    Selected HMDB Compounds for CYP4F2 (see all 25)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-dihydro-20-dihydroxy-LTB410,11-dihydroxy-20-dihydroxy-LTB(,4) (see all 3)----
    10,11-dihydro-20-trihydroxy-leukotriene B4(5S,12R,20)-pentahydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 3)----
    12(S)-Leukotriene B42-epi-LTB4 (see all 7)83709-73-3--
    12-Keto-tetrahydro-leukotriene B412-keto-10,11,14,15-tetrahydro-LTB4 (see all 3)----
    12-Oxo-20-hydroxy-leukotriene B412-keto-20-hydroxy-leukotriene B(,4) (see all 6)----
    12-Oxo-20-trihydroxy-leukotriene B412-oxo-20,20,20-trihydroxy-leukotriene B(,4) (see all 6)----
    12-oxo-20-dihydroxy-leukotriene B412-oxo-20,20-dihydroxy-leukotriene B(,4) (see all 7)----
    13'-Carboxy-gama-tocopherol2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-chromanol;2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-hydroxychroman ----
    13'-Hydroxy-gama-tocopherol13'-OH-tocopherol ----
    13'-Hydroxy-gama-tocotrienol13OHgamaTE ----

    5 Novoseek inferred chemical compound relationships for CYP4F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    20-hydroxyeicosatetraenoic acid 89.6 23 9618440 (5), 18235092 (3), 18391101 (2), 10660572 (2) (see all 6)
    leukotriene b4 79.4 12 10492403 (2), 10833273 (1), 11056396 (1), 9875512 (1) (see all 7)
    arachidonic acid 69.1 18 9618440 (4), 10660572 (2), 11056396 (1), 15994032 (1) (see all 8)
    clofibrate 56 2 10492403 (1), 9875512 (1)
    retinoic acid 14.9 6 11162441 (2), 10860554 (1)

    4 PharmGKB related drug/compound annotations for CYP4F2 gene    About this table
    Drug/compound PharmGKB Annotation
    acenocoumarol  CA  
    phenprocoumon  CA  
    vitamin eCA  
    warfarin  CA  



    Find genes that share compounds with CYP4F2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP4F2 gene: 
    NM_001082.3  

    Unigene Cluster for CYP4F2:

    Cytochrome P450, family 4, subfamily F, polypeptide 2
    Hs.558423  [show with all ESTs]
    Unigene Representative Sequence: U02388
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392846 ENST00000221700(uc002nbs.1 uc010xot.1 uc010xou.1)
    ENST00000589654 ENST00000592710 ENST00000587671 ENST00000586927 ENST00000608168
    ENST00000011989
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    Additional mRNA sequence: 

    AK290790.1 AK296200.1 AK300961.1 AK313705.1 BC067437.1 BC067438.1 BC067439.1 BC067440.1 
    D26480.1 U02388.2 

    4 DOTS entries:

    DT.101958587  DT.121496202  DT.452202  DT.95372012 

    Selected AceView cDNA sequences (see all 61):

    AA377259 AW118600 NM_001082 BC067439 CB157546 CB161237 AV655184 BE552106 
    AA244020 CF271899 CA444522 CK130197 CF271898 CA423188 CK130195 AW771881 
    BC067437 CK130196 U02388 BC067440 BG697996 CK032817 CF271900 CB157046 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                                                                                    
    SP2:                                                              -                     
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CYP4F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP4F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP4F2 Expression
    About this image


    CYP4F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    CYP4F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4F2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558423

    UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329
    Tissue specificity: Liver

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F2: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP4F2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4f181 , 5 cytochrome P450, family 4, subfamily f, polypeptide more1, 5 78.59(n)1
    76.35(a)1
      8 (34.67 cM)5
    720541  NM_024444.21  NP_077764.21 
     719884825 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    72(a)
    1 → many
    AADN03027099.1(283-5104)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    63(a)
    many ↔ many
    many ↔ many
    AAWZ02039718(3621-5749)
    2(79856458-79966876)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4f31 cytochrome P450, family 4, subfamily F, polypeptide more 60.73(n)
    55.14(a)
      100037390  NM_001089541.1  NP_001083010.1 


    ENSEMBL Gene Tree for CYP4F2 (if available)
    TreeFam Gene Tree for CYP4F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4F2 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F112  CYP3A432  CYP3A42  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    14 SIMAP similar genes for CYP4F2 using alignment to 6 protein entries:     CP4F2_HUMAN (see all proteins):
    DKFZp761K058    CYP4F11    CYP4F8    CYP4F3    CYP4F12    CYP4F22
    DKFZp686F1316    CYP4B1    CYP4X1    CYP4Z1    CYP4A11    CYP4Z2P
    CYP4V2    CYP4A22

    Find genes that share paralogs with CYP4F2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CYP4F2 (see all 7)
    PGOHUM00000235016 PGOHUM00000234188 PGOHUM00000234532 PGOHUM00000239026 PGOHUM00000240293


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4F2 (see all 744)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406309771,2
    Cuntested115934685(+) GCATCC/TGACGG 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs1484074961,2
    --15919845(+) TGATAC/TGATAA 1 -- ds50010--------
    rs30932101,2
    C,F--15919888(-) GAGTCG/AGGGGT 1 -- ds500114Minor allele frequency- A:0.06NS NA WA CSA EA 458
    rs30932091,2
    C,F,A--15919907(-) GGTCAC/GTCAGT 1 -- ds50019Minor allele frequency- G:0.23NS NA CSA WA EA 452
    rs1425436791,2
    C--15919947(+) AAGATC/TGATGT 1 -- ds50010--------
    rs30932081,2
    C,F,H--15920069(-) AACAGT/CTATGA 1 -- ds500114Minor allele frequency- C:0.08NS EA WA 1242
    rs1826994591,2
    --15920130(+) CTATTC/GCTGTG 1 -- ds50010--------
    rs30932071,2
    C,F,H--15920145(-) TAGAGA/GTCTCA 1 -- ds500126Minor allele frequency- G:0.26NS EA NA CSA WA 2854
    rs177566541,2
    C,F--15920212(+) TGAAGC/ATAATT 1 -- ds50017Minor allele frequency- A:0.24NA EA 360
    rs30932061,2
    C,F--15920240(-) AATAAAA/-GTGTT 1 -- ds50012Minor allele frequency- -:0.21NS 88

    HapMap Linkage Disequilibrium report for CYP4F2 (15988833 - 16008930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP4F2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1124839CNV Deletion17803354
    esv2671181CNV Deletion23128226
    esv2676393CNV Deletion23128226
    esv2718249CNV Deletion23290073
    esv2718247CNV Deletion23290073
    esv1958771CNV Deletion18987734
    esv2718252CNV Deletion23290073
    esv2718244CNV Deletion23290073
    esv2718248CNV Deletion23290073
    nsv833766CNV Loss17160897

    The Human Cytochrome P450 Allele Nomenclature Database: CYP4F2 
    Human Gene Mutation Database (HGMD): CYP4F2
    Locus Specific Mutation Databases (LSDB): CYP4F2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4F2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4F2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604426    OMIM disorders: --

    1 disease for CYP4F2:    
    About MalaCards
    warfarin sensitivity


    Find genes that share disorders with CYP4F2           About GenesLikeMe

    1 Novoseek inferred disease relationship for CYP4F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 3 10492403 (1), 18433732 (1), 16835590 (1)

    Genetic Association Database (GAD): CYP4F2
    Human Genome Epidemiology (HuGE) Navigator: CYP4F2 (49 documents)

    Export disorders for CYP4F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4F2 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with CYP4F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel form of leukotriene B4 omega- hydroxylase from human liver. (PubMed id 8026587)1, 2, 3 Kikuta Y....Kusunose M. (FEBS Lett. 1994)
    2. CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. (PubMed id 19297519)1, 4, 9 McDonald M.G....Rettie A.E. (Mol. Pharmacol. 2009)
    3. Expression and molecular cloning of human liver leukotriene B4 omega- hydroxylase (CYP4F2) gene. (PubMed id 10492403)1, 2, 9 Kikuta Y.... Kusunose M. (DNA Cell Biol. 1999)
    4. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. (PubMed id 18235092)1, 4, 9 Liu H....Lu J. (J. Am. Soc. Nephrol. 2008)
    5. CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. (PubMed id 20227456)1, 4, 9 Deng S....Zhiyi H. (amp 2010)
    6. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. (PubMed id 18391101)1, 4, 9 Ward N.C....Croft K.D. (Hypertension 2008)
    7. Promoter activity and regulation of the CYP4F2 leukotriene B4 omega hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells. (PubMed id 10860554)1, 2, 9 Zhang X.... Hardwick J.P. (Arch. Biochem. Biophys. 2000)
    8. A genome-wide association study of acenocoumarol maintenance dosage. (PubMed id 19578179)1, 4, 9 Teichert M....Stricker B.H. (Hum. Mol. Genet. 2009)
    9. A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. (PubMed id 18787519)1, 4, 9 Fu Z....Ma Y. (Am. J. Hypertens. 2008)
    10. Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. (PubMed id 22437554)1, 4 Major J.M....Albanes D. (J. Nutr. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8529 HGNC: 2645 AceView: CYP4F2 Ensembl:ENSG00000186115 euGenes: HUgn8529
    ECgene: CYP4F2 Kegg: 8529 H-InvDB: CYP4F2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP4F2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cyp4f2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4F2 gene:
    Search GeneIP for patents involving CYP4F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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