CYP4F2 Gene
protein-coding GIFtS: 63
GCID: GC19M015988
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cytochrome P450, family 4, subfamily F, polypeptide 2(Previous names: cytochrome P450, subfamily IVF, polypeptide 2 )
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Aliases
for CYP4F2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 4, Subfamily F, Polypeptide 21 2 | | CPF22 | | Cytochrome P450, Subfamily IVF, Polypeptide 21 2 | | Leukotriene B4 Omega-Hydroxylase2 | | Cytochrome P450 4F22 3 | | Leukotriene-B(4) Omega-Hydroxylase 12 | | Cytochrome P450-LTB-Omega2 3 | | Leukotriene-B4 20-Monooxygenase2 | | Leukotriene-B(4) 20-Monooxygenase 12 3 | | EC 1.14.13.303 | | CYPIVF22 3 | | |
Export aliases for CYP4F2 gene to outside databasesPrevious GC identifers: GC19M016474 GC19M015725 GC19M015849 GC19M015560 |
Summaries
for CYP4F2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP4F2:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating anddegrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 geneson chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved inan NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, includingsteroids, fatty acids, and xenobiotics
Gene Wiki entry for CYP4F2
|
Genomic Views
for CYP4F2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP4F2 gene promoter:
p53 HSF1 (long) Pax-2 Pax-2a GATA-2 YY1 RORalpha1 FOXO4 HOXA5 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP4F2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12CYP4F2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M015988: view genomic region
(about GC identifiers)
Start:
|
15,988,834 bp from pter |
End:
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16,008,884 bp from pter |
Size:
|
20,051 bases |
Orientation:
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minus strand |
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Proteins
for CYP4F2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329 (See
protein sequence)Recommended Name: Leukotriene-B(4) omega-hydroxylase 1 Size: 520 amino acids; 59853 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheralmembrane protein
Secondary accessions: A8K425 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8Explore the universe of human proteins at neXtProt for CYP4F2: NX_P78329
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P78329
CYP4F2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073.3
ENSEMBL proteins: ENSP00000221700 ENSP00000464999 ENSP00000467846 ENSP00000467443 ENSP00000465514 ENSP00000011989 Reactome Protein details: P78329
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CYP4F2 for ontologies About GeneDecksing
CYP4F2 Antibody Products:
Assay Products for CYP4F2: |
Protein
Domains /
Families
for CYP4F2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP4F2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P78329ProtoNet protein and cluster: P78329 1 Blocks protein family: IPB002402 Group II E-class P450 signature
UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329Similarity: Belongs to the cytochrome P450 family |
Function
for CYP4F2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved inan NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, includingsteroids, fatty acids, and xenobioticsCatalytic activity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) =(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O Genatlas biochemistry entry for CYP4F2:leukotriene B4 omega-hydroxylase,involved in the degradation of LTB4,a potent mediator of inflammation
Enzyme Number (IUBMB): EC 1.14.13.301
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP4F2 (NM_001082) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F2 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
CYP4F2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYP4F2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Arachidonic acid metabolism | | | 2 | Cytochrome P450 - arranged by substrate type | | | 3 | Metabolism | | | 4 | Biological oxidations | | | 5 | Eicosanoids | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CYP4F2
1  GeneGo (Thomson Reuters) Pathway for CYP4F2
3  BioSystems Pathways for CYP4F2
5/9 
Reactome Pathways for CYP4F2 (see all 9)
2 
Kegg Pathways (Kegg details for CYP4F2):
CYP4F2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4F2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for CYP4F2 (P783291, 3 ENSP000002217004) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
CYP4F2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP4F2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP4F2 for compounds About GeneDecksing
 Browse Tocris compounds for CYP4F2
10/25 HMDB Compounds for CYP4F2 (see all 25) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 10,11-dihydro-20-dihydroxy-LTB4 | 10,11-dihydroxy-20-dihydroxy-LTB(,4) (see all 3) | -- | -- | | 10,11-dihydro-20-trihydroxy-leukotriene B4 | (5S,12R,20)-pentahydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 3) | -- | -- | | 12(S)-Leukotriene B4 | 2-epi-LTB4 (see all 7) | 83709-73-3 | -- | | 12-Keto-tetrahydro-leukotriene B4 | 12-keto-10,11,14,15-tetrahydro-LTB4 (see all 3) | -- | -- | | 12-Oxo-20-hydroxy-leukotriene B4 | 12-keto-20-hydroxy-leukotriene B(,4) (see all 6) | -- | -- | | 12-Oxo-20-trihydroxy-leukotriene B4 | 12-oxo-20,20,20-trihydroxy-leukotriene B(,4) (see all 6) | -- | -- | | 12-oxo-20-dihydroxy-leukotriene B4 | 12-oxo-20,20-dihydroxy-leukotriene B(,4) (see all 7) | -- | -- | | 13'-Carboxy-gama-tocopherol | 2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-chromanol;2,7,8-trimethyl-2-(13'-carboxy-4',8',12'-trimethyltridecyl)-6-hydroxychroman | -- | -- | | 13'-Hydroxy-gama-tocopherol | 13'-OH-tocopherol | -- | -- | | 13'-Hydroxy-gama-tocotrienol | 13OHgamaTE | -- | -- |
5 Novoseek chemical compound relationships for CYP4F2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 20-hydroxyeicosatetraenoic acid |
89.6 |
23 |
9618440 (5), 18235092 (3), 18391101 (2), 10660572 (2) (see all 6) |
| leukotriene b4 |
79.4 |
12 |
10492403 (2), 10833273 (1), 11056396 (1), 9875512 (1) (see all 7) |
| arachidonic acid |
69.1 |
18 |
9618440 (4), 10660572 (2), 11056396 (1), 15994032 (1) (see all 8) |
| clofibrate |
56 |
2 |
10492403 (1), 9875512 (1) |
| retinoic acid |
14.9 |
6 |
11162441 (2), 10860554 (1) |
3 PharmGKB related drug/compound annotations for CYP4F2 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about CYP4F2 / CP4F2
|
Transcripts
for CYP4F2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP4F2 gene: NM_001082.3 Unigene Cluster for CYP4F2: Cytochrome P450, family 4, subfamily F, polypeptide 2 Hs.558423 [show with all ESTs]Unigene Representative Sequence: U023888 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221700(uc002nbs.1 uc010xot.1 uc010xou.1) ENST00000592328
ENST00000392846 ENST00000589654 ENST00000592710 ENST00000587671 ENST00000586927
ENST00000011989
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP4F2 (NM_001082) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F2 |
Additional cDNA sequence: AK290790.1 AK296200.1 AK300961.1 AK313705.1 BC067437.1 BC067438.1 BC067439.1 BC067440.1 D26480.1 U02388.2 4 DOTS entries: DT.101958587 DT.121496202 DT.452202 DT.95372012 24/61 AceView cDNA sequences (see all 61): BE552106 BC067439 CB157546 AV655184 AW118600 NM_001082 CB161237 AA377259 AI953391 CK032817 AI364951 CA444522 AW771881 CK130196 CB157046 CF271900 CB162371 BI763623 CF271895 CF271894 BC067437 BG054501 CK130195 AA244020
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYP4F2
|
Expression
for CYP4F2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP4F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CYP4F2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4F2
SOURCE GeneReport for Unigene cluster: Hs.558423
UniProtKB/Swiss-Prot: CP4F2_HUMAN, P78329Tissue specificity: Liver
SABiosciences Expression via Pathway-Focused PCR Array including CYP4F2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP4F2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F2 |
Orthologs
for CYP4F2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYP4F2 gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for CYP4F2 (if available)
TreeFam Gene Tree for CYP4F2 (if available) |
Paralogs
for CYP4F2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP4F2 gene
- CYP4F222 CYP4F32 CYP4F112 CYP46A12 ENSG000002256072 CYP4B12 CYP3A52 CYP4X12
- TBXAS12 CYP3A42 CYP3A432 CYP3A72 CYP4V22 CYP4A222 CYP4A112 CYP4F122
- CYP4Z12
17 SIMAP similar genes for CYP4F2 using alignment to 7 protein entries: CP4F2_HUMAN (see all proteins):DKFZp761K058 CYP4F3 CYP4F11 CYP4F8 CYP4F12 CYP4F22
DKFZp686F1316 CYP4B1 CYP4A11 CYP4X1 CYP4Z1 CYP4Z2P
CYP3A5 CYP4V2 CYP4A22 CYP2C9 CYP3A43/CYP3A4
CYP4F2 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for CYP4F2 (see all 7)
PGOHUM00000235016 PGOHUM00000234188 PGOHUM00000234532 PGOHUM00000239026 PGOHUM00000240293
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Genomic Variants
for CYP4F2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP4F2 (15988834 - 16008884 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYP4F2
2 Indels: 45729 26199
Human Gene Mutation Database (HGMD): CYP4F2
Locus Specific Mutation Databases (LSDB): CYP4F2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F2 |
|
Disorders
/ Diseases
for CYP4F2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP4F2 for disorders About GeneDecksing
OMIM gene information: 604426
OMIM disorders: --
17  diseases for CYP4F2: About MalaCardswarfarin sensitivity essential hypertension myocardial infarction adrenoleukodystrophy
cerebral infarction ichthyosis cholesterol hepatoblastoma
lung adenocarcinoma hypertension cerebritis adenocarcinoma
tuberculosis hepatitis venous thromboembolism mycobacterium tuberculosis
thromboembolism
1 Novoseek disease relationship for CYP4F2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
0 |
3 |
10492403 (1), 18433732 (1), 16835590 (1) |
Human Genome Epidemiology (HuGE) Navigator: CYP4F2 (49 documents)
Export disorders for CYP4F2 gene to outside databases
|
Publications
for CYP4F2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP4F2 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with CYP4F2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of a novel form of leukotriene B4 omega- hydroxylase from human liver. (PubMed id 8026587)1, 2, 3 Kikuta Y....Kusunose M. (1994)
- Expression and molecular cloning of human liver leukotriene B4 omega- hydroxylase (CYP4F2) gene. (PubMed id 10492403)1, 2, 9 Kikuta Y.... Kusunose M. (1999)
- Promoter activity and regulation of the CYP4F2 leukotriene B4 omega hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells. (PubMed id 10860554)1, 2, 9 Zhang X.... Hardwick J.P. (2000)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. (PubMed id 8424651)1, 3 Chen L. and Hardwick J.P. (1993)
- Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. (PubMed id 17142457)1, 9 Hsu M.H....Johnson E.F. (2007)
- CYP4F2 Is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. (PubMed id 19297519)1, 9 McDonald M.G....Rettie A.E. (2009)
- Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. (PubMed id 9618440)1, 9 Powell P.K....Lasker J.M. (1998)
- Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. (PubMed id 18235092)1, 9 Liu H....Lu J. (2008)
|
External Searches for CYP4F2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP4F2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP4F2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP4F2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CYP4F2 | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/cyp4f2/ |
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About This Section
| Patent Information for CYP4F2 gene:
Search GeneIP for patents involving CYP4F2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYP4F2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP4F2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP4F2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP4F2 | | OriGene 3'-UTR Clone for CYP4F2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP4F2 | | OriGene Custom Protein Services for CYP4F2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP4F2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP4F2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F2 |
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| | | | Search Tocris compounds for CYP4F2 |
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 | | | CYP4F2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F2 |
|  |  |  | | | | ThermoFisher Antibodies for CYP4F2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F2 |
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