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Aliases for CYP4F12 Gene

Aliases for CYP4F12 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 12 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 12 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 12 2 3
  • CYPIVF12 3 4
  • EC 1.14.14.1 4
  • F22329_1 3

External Ids for CYP4F12 Gene

Previous GeneCards Identifiers for CYP4F12 Gene

  • GC19M016362
  • GC19P016177
  • GC19P015483
  • GC19P015644
  • GC19P015783
  • GC19P015352

Summaries for CYP4F12 Gene

Entrez Gene Summary for CYP4F12 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP4F12 Gene

CYP4F12 (Cytochrome P450 Family 4 Subfamily F Member 12) is a Protein Coding gene. Among its related pathways are Phase II conjugation and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP4F12 Gene

  • Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.

Gene Wiki entry for CYP4F12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F12 Gene

Genomics for CYP4F12 Gene

Regulatory Elements for CYP4F12 Gene

Enhancers for CYP4F12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP4F12 on UCSC Golden Path with GeneCards custom track

Promoters for CYP4F12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYP4F12 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4F12 Gene

Chromosome:
19
Start:
15,672,757 bp from pter
End:
15,698,819 bp from pter
Size:
26,063 bases
Orientation:
Plus strand

Genomic View for CYP4F12 Gene

Genes around CYP4F12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F12 Gene

Proteins for CYP4F12 Gene

  • Protein details for CYP4F12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCS2-CP4FC_HUMAN
    Recommended name:
    Cytochrome P450 4F12
    Protein Accession:
    Q9HCS2
    Secondary Accessions:
    • E7ET51
    • O60389
    • Q5JPJ7
    • Q9HCS1

    Protein attributes for CYP4F12 Gene

    Size:
    524 amino acids
    Molecular mass:
    60270 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW84492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CYP4F12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F12 Gene

Proteomics data for CYP4F12 Gene at MOPED

Post-translational modifications for CYP4F12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F12 Gene

No data available for DME Specific Peptides for CYP4F12 Gene

Domains & Families for CYP4F12 Gene

Gene Families for CYP4F12 Gene

Protein Domains for CYP4F12 Gene

Suggested Antigen Peptide Sequences for CYP4F12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCS2

UniProtKB/Swiss-Prot:

CP4FC_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F12: view

Function for CYP4F12 Gene

Molecular function for CYP4F12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.

Enzyme Numbers (IUBMB) for CYP4F12 Gene

Gene Ontology (GO) - Molecular Function for CYP4F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008392 arachidonic acid epoxygenase activity ISS --
genes like me logo Genes that share ontologies with CYP4F12: view
genes like me logo Genes that share phenotypes with CYP4F12: view

Animal Models for CYP4F12 Gene

MGI Knock Outs for CYP4F12:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4F12 Gene

Localization for CYP4F12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F12 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4F12 Gene COMPARTMENTS Subcellular localization image for CYP4F12 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 2
cytosol 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4F12 Gene

Pathways & Interactions for CYP4F12 Gene

genes like me logo Genes that share pathways with CYP4F12: view

Pathways by source for CYP4F12 Gene

Interacting Proteins for CYP4F12 Gene

Gene Ontology (GO) - Biological Process for CYP4F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process ISS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0019373 epoxygenase P450 pathway ISS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CYP4F12: view

No data available for SIGNOR curated interactions for CYP4F12 Gene

Drugs & Compounds for CYP4F12 Gene

(4) Drugs for CYP4F12 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fingolimod Approved, Investigational Pharma Enzyme, substrate 0
heme Pharma Agonist 0

(3) Additional Compounds for CYP4F12 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with CYP4F12: view

Transcripts for CYP4F12 Gene

Unigene Clusters for CYP4F12 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F12 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9: - -

Relevant External Links for CYP4F12 Gene

GeneLoc Exon Structure for
CYP4F12
ECgene alternative splicing isoforms for
CYP4F12

Expression for CYP4F12 Gene

mRNA expression in normal human tissues for CYP4F12 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4F12 Gene

This gene is overexpressed in Liver (x5.8), Small Intestine - Terminal Ileum (x5.6), Colon - Transverse (x5.1), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for CYP4F12 Gene

This gene is overexpressed in Stomach (35.3), Gallbladder (16.2), and Liver (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP4F12 Gene



SOURCE GeneReport for Unigene cluster for CYP4F12 Gene Hs.131459

mRNA Expression by UniProt/SwissProt for CYP4F12 Gene

Q9HCS2-CP4FC_HUMAN
Tissue specificity: Expressed in small intestine, liver, colon and heart.
genes like me logo Genes that share expression patterns with CYP4F12: view

Protein tissue co-expression partners for CYP4F12 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYP4F12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F12 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp4f14 35
  • 78.99 (n)
  • 75.1 (a)
Cyp4f14 16
Cyp4f14 36
  • 75 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC468754 35
  • 98.16 (n)
  • 96.56 (a)
CYP4F12 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4f1 35
  • 79.2 (n)
  • 75.38 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
CYP4F2 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp311a1 37
  • 30 (a)
Cyp312a1 37
  • 31 (a)
Cyp313a4 37
  • 27 (a)
Cyp313b1 37
  • 26 (a)
Cyp4aa1 37
  • 26 (a)
Cyp4ac1 37
  • 31 (a)
Cyp4ac2 37
  • 30 (a)
Cyp4ac3 37
  • 35 (a)
Cyp4ad1 37
  • 28 (a)
Cyp4ae1 37
  • 32 (a)
Cyp4c3 37
  • 36 (a)
Cyp4d1 37
  • 34 (a)
Cyp4d14 37
  • 38 (a)
Cyp4d2 37
  • 37 (a)
Cyp4d20 37
  • 33 (a)
Cyp4d21 37
  • 32 (a)
Cyp4d8 37
  • 34 (a)
Cyp4e1 37
  • 31 (a)
Cyp4e2 37
  • 31 (a)
Cyp4e3 37
  • 32 (a)
Cyp4g1 37
  • 26 (a)
Cyp4g15 37
  • 36 (a)
Cyp4p1 37
  • 33 (a)
Cyp4p2 37
  • 32 (a)
Cyp4p3 37
  • 33 (a)
Cyp4s3 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea B0331.1 37
  • 34 (a)
C26F1.2 37
  • 31 (a)
F01D5.9 37
  • 34 (a)
F28G4.1 37
  • 33 (a)
Y17G9B.3 37
  • 34 (a)
Y38C9B.1 37
  • 32 (a)
Y5H2B.5 37
  • 36 (a)
Y80D3A.5 37
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BAS1 35
  • 44.65 (n)
  • 33.42 (a)
rice
(Oryza sativa)
Liliopsida Os02g0204700 35
  • 46.82 (n)
  • 34.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
CSA.3998 36
  • 39 (a)
ManyToMany
CSA.6060 36
  • 39 (a)
ManyToMany
CSA.8060 36
  • 39 (a)
ManyToMany
Species with no ortholog for CYP4F12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F12 Gene

ENSEMBL:
Gene Tree for CYP4F12 (if available)
TreeFam:
Gene Tree for CYP4F12 (if available)

Paralogs for CYP4F12 Gene

Pseudogenes.org Pseudogenes for CYP4F12 Gene

genes like me logo Genes that share paralogs with CYP4F12: view

Variants for CYP4F12 Gene

Sequence variations from dbSNP and Humsavar for CYP4F12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs16995376 - 15,673,567(+) CAGAC(C/G/T)GGTGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs609636 - 15,678,288(-) CGAGT(C/T)CTTCA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs609290 - 15,678,330(-) CCATA(C/T)CGTAA upstream-variant-2KB, reference, missense, splice-donor-variant
rs2285888 - 15,682,425(+) GCAGT(C/T)GTCTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs16995378 - 15,673,576(+) GGCAA(C/T)GTCCC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CYP4F12 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
dgv627e199 CNV Deletion 23128226
esv2718235 CNV Deletion 23290073
nsv470128 CNV Gain 18288195
nsv516707 CNV Gain 19592680
nsv9671 CNV Gain 18304495
dgv137e55 CNV Gain 17911159
esv22534 CNV Gain+Loss 19812545
esv2421519 CNV Duplication 20811451
dgv397n27 CNV Gain 19166990
nsv458360 CNV Gain 19166990
dgv28n64 CNV Gain 17921354
dgv398n27 CNV Gain 19166990
dgv1059e1 CNV Complex 17122850
nsv442455 CNV CNV 18776908
dgv1060e1 CNV Complex 17122850
nsv526168 CNV Gain 19592680
nsv436858 CNV Insertion 17901297
esv2661737 CNV Deletion 23128226
esv2660305 CNV Deletion 23128226
esv2718238 CNV Deletion 23290073
esv7528 CNV Loss 19470904
esv2718240 CNV Deletion 23290073
esv1195281 CNV Deletion 17803354
esv3260 OTHER Inversion 18987735
esv2718241 CNV Deletion 23290073
esv1181428 CNV Insertion 17803354
esv6588 CNV Loss 19470904
esv1095444 CNV Deletion 17803354
esv2742342 CNV Deletion 23290073
esv1556855 CNV Deletion 17803354
esv1436299 CNV Deletion 17803354
dgv547e201 CNV Deletion 23290073
dgv548e201 CNV Deletion 23290073
dgv549e201 CNV Deletion 23290073
esv1047697 CNV Deletion 17803354
esv1029693 CNV Insertion 17803354
esv1237749 CNV Insertion 17803354
esv2125708 CNV Deletion 18987734
esv1718200 CNV Insertion 17803354
nsv442761 CNV CNV 18776908

Variation tolerance for CYP4F12 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4F12 Gene

HapMap Linkage Disequilibrium report
CYP4F12
Human Gene Mutation Database (HGMD)
CYP4F12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F12 Gene

Disorders for CYP4F12 Gene

Relevant External Links for CYP4F12

Genetic Association Database (GAD)
CYP4F12
Human Genome Epidemiology (HuGE) Navigator
CYP4F12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F12

No disorders were found for CYP4F12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4F12 Gene

Publications for CYP4F12 Gene

  1. cDNA cloning and expression of CYP4F12, a novel human cytochrome P450. (PMID: 11162607) Bylund J. … Oliw E.H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Expression and physiological function of CYP4F subfamily in human eosinophils. (PMID: 17980168) Kikuta Y. … Ohkawa H. (Biochim. Biophys. Acta 2007) 3 23
  3. Expression of CYP4F12 in gastrointestinal and urogenital epithelia. (PMID: 15078342) Stark K. … Oliw E.H. (Basic Clin. Pharmacol. Toxicol. 2004) 3 23
  4. Functional characterization of genetic polymorphisms identified in the human cytochrome P450 4F12 (CYP4F12) promoter region. (PMID: 15163554) Cauffiez C. … Lo-Guidice J.M. (Biochem. Pharmacol. 2004) 3 23
  5. Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes. (PMID: 15548388) Cauffiez C. … Broly F. (Biochem. Pharmacol. 2004) 3 23

Products for CYP4F12 Gene

Sources for CYP4F12 Gene

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