Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CYP4F12 Gene

protein-coding   GIFtS: 63
GCID: GC19P015783

Cytochrome P450, Family 4, Subfamily F, Polypeptide 12

(Previous names: cytochrome P450, subfamily IVF, polypeptide 12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome P450, Family 4, Subfamily F, Polypeptide 121 2
Cytochrome P450, Subfamily IVF, Polypeptide 121 2
CYPIVF122 3
F22329_12
Cytochrome P450 4F122
EC 1.14.14.13

External Ids:    HGNC: 188571   Entrez Gene: 660022   Ensembl: ENSG000001862047   OMIM: 6114855   UniProtKB: Q9HCS23   

Export aliases for CYP4F12 gene to outside databases

Previous GC identifers: GC19M016362 GC19P016177 GC19P015483 GC19P015644 GC19P015352


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CYP4F12 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme
is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene
is part of a cluster of cytochrome P450 genes on chromosome 19. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4F12 Gene:
CYP4F12 (cytochrome P450, family 4, subfamily F, polypeptide 12) is a protein-coding gene. Diseases associated with CYP4F12 include warfarin sensitivity, and tuberculosis. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2
Function: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an
activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine

Gene Wiki entry for CYP4F12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4F12 gene promoter:
         Max1   Pbx1a   Brachyury   HSF1 (long)   RORalpha1   PPAR-gamma1   HOXA5   HSF1short   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4F12 promoter sequence
   Search Chromatin IP Primers for CYP4F12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4F12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

CYP4F12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4F12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015783:  view genomic region     (about GC identifiers)

Start:
15,783,567 bp from pter      End:
15,807,984 bp from pter
Size:
24,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2 (See protein sequence)
Recommended Name: Cytochrome P450 4F12  
Size: 524 amino acids; 60270 Da
Cofactor: Heme group (By similarity)
Sequence caution: Sequence=EAW84492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60389 Q9HCS1

Explore the universe of human proteins at neXtProt for CYP4F12: NX_Q9HCS2

Explore proteomics data for CYP4F12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP4F12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076433.3  
    ENSEMBL proteins: 
     ENSP00000448998   ENSP00000448560   ENSP00000446812   ENSP00000449703   ENSP00000430849  
     ENSP00000447922   ENSP00000321821  
    Reactome Protein details: Q9HCS2

    CYP4F12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CYP4F12
    OriGene Protein Over-expression Lysate for CYP4F12
    OriGene MassSpec for CYP4F12
    OriGene Custom Protein Services for CYP4F12
    GenScript Custom Purified and Recombinant Proteins Services for CYP4F12
    Novus Biologicals CYP4F12 Protein
    Novus Biologicals CYP4F12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYP4F12

    CYP4F12 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP4F12
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CYP4F12
    Novus Biologicals CYP4F12 Antibodies
    Abcam antibodies for CYP4F12
    Cloud-Clone Corp. Antibodies for CYP4F12
    ThermoFisher Antibodies for CYP4F12
    LSBio Antibodies in human, mouse, rat for CYP4F12

    CYP4F12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYP4F12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYP4F12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYP4F12
    Cloud-Clone Corp. CLIAs for CYP4F12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4F12
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q9HCS2

    ProtoNet protein and cluster: Q9HCS2

    1 Blocks protein domain: IPB002403 E-class P450 group IV signature

    UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2
    Similarity: Belongs to the cytochrome P450 family


    CYP4F12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4FC_HUMAN, Q9HCS2
    Function: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an
    activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Enzyme Number (IUBMB): EC 1.14.14.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0008392arachidonic acid epoxygenase activity ISS--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0018685alkane 1-monooxygenase activity ISS--
    GO:0020037heme binding IEA--
         
    CYP4F12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYP4F12:
     Decreased cell number and incr 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cyp4f14):
     digestive/alimentary  homeostasis/metabolism  renal/urinary system 

    CYP4F12 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4F12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP4F12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP4F12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP4F12

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CYP4F12 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CYP4F12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYP4F12
    Predesigned siRNA for gene silencing in human, mouse, rat CYP4F12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYP4F12

    Clone
    Products:
         
    OriGene clones in human, mouse for CYP4F12 (see all 6)
    OriGene ORF clones in mouse, rat for CYP4F12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP4F12 (NM_023944)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP4F12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F12

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYP4F12
    Browse ESI BIO Cell Lines and PureStem Progenitors for CYP4F12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CP4FC_HUMAN, Q9HCS2: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Microsome
    membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane4
    extracellular2
    cytosol1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane ISS--
    GO:0043231intracellular membrane-bounded organelle ISS--

    CYP4F12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CYP4F12 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Eicosanoids0.00
    cytochrome P4500.74
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Tryptophan metabolism
    Tryptophan metabolism0.46
    4Metabolism
    Metabolism0.38
    5Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYP4F12
        Prostaglandin 2 biosynthesis and metabolism FM

    3 BioSystems Pathways for CYP4F12
        cytochrome P450
    metapathway biotransformation
    Tryptophan metabolism

    2 Reactome Pathways for CYP4F12
        Fatty acids
    Eicosanoids



    CYP4F12 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F12: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4F12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CYP4F12 (ENSP000003218214) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA6ENSP000003102194STRING: ENSP00000310219
    SOD2ENSP000003371274STRING: ENSP00000337127
    LSSENSP000003487624STRING: ENSP00000348762
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    SQLEENSP000002658964STRING: ENSP00000265896
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process ISS--
    GO:0001676long-chain fatty acid metabolic process ISS--
    GO:0003091renal water homeostasis ISS--
    GO:0003095pressure natriuresis ISS--
    GO:0006805xenobiotic metabolic process TAS--

    CYP4F12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4F12 (CP4FC)

    9 HMDB Compounds for CYP4F12    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    17-HETE17-hydroxyeicosatetraenate (see all 3)----
    2beta-Hydroxytestosterone2beta,17beta-dihydroxyandrost-4-en-3-one 10390-14-4--
    5-Oxo-6-trans-leukotriene B45-oxo-6E-LTB(,4) (see all 3)----
    6,7-dihydro-12-epi-LTB46,7-dihydro-12-epi-leukotriene B(,4) (see all 4)----
    6,7-dihydro-5-oxo-12-epi-LTB46,7-dihydro-5-oxo-12-epi-leukotriene B(,4) (see all 4)----
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    3 Novoseek inferred chemical compound relationships for CYP4F12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ebastine 86.6 2 15078342 (1)
    leukotriene b4 68.3 10 17980168 (1), 11162607 (1)
    arachidonic acid 50.1 3 15078342 (1), 11162607 (1)



    CYP4F12 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CYP4F12 gene: 
    NM_023944.3  

    Unigene Cluster for CYP4F12:

    Cytochrome P450, family 4, subfamily F, polypeptide 12
    Hs.131459  [show with all ESTs]
    Unigene Representative Sequence: AK075435
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550308(uc002nbl.3) ENST00000547332 ENST00000547471 ENST00000451750(uc010xoo.2)
    ENST00000430608(uc010xop.2) ENST00000548237 ENST00000518629 ENST00000548501
    ENST00000549622 ENST00000548435 ENST00000546792 ENST00000550264 ENST00000517734
    ENST00000551607 ENST00000324632 ENST00000550627 ENST00000546608
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYP4F12 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CYP4F12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYP4F12
    Predesigned siRNA for gene silencing in human, mouse, rat CYP4F12
    Clone
    Products:
         
    OriGene clones in human, mouse for CYP4F12 (see all 6)
    OriGene ORF clones in mouse, rat for CYP4F12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP4F12 (NM_023944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP4F12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F12
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP4F12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP4F12
      QuantiTect SYBR Green Assays in human, mouse, rat CYP4F12
      QuantiFast Probe-based Assays in human, mouse, rat CYP4F12

    Additional mRNA sequence: 

    AB035130.1 AB035131.1 AK075435.1 AK304138.1 AK304389.1 AY008841.1 AY358977.1 BC035350.1 

    11 DOTS entries:

    DT.455404  DT.100783492  DT.97840225  DT.121503023  DT.100021062  DT.100642514  DT.121503040  DT.101978269 
    DT.121503041  DT.412029  DT.95321197 

    Selected AceView cDNA sequences (see all 32):

    BI759580 AK074412 AL832171 BM767149 CB142482 AY008841 AY358977 BM772910 
    BM737770 BC034916 BC035350 BM772906 CD631824 AA305180 AA494546 BX481676 
    BM738347 AK075435 AB035130 CB115664 NM_023944 CD514734 AB035131 BM738084 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F12 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
    SP1:                                            -     -     -     -     -     -                                                     -               
    SP2:                    -                       -     -     -     -     -     -                                                                     
    SP3:                                            -     -     -     -     -     -                                                                     
    SP4:              -     -                       -     -                       -                                                                     
    SP5:                    -                       -     -                                                                                             


    ECgene alternative splicing isoforms for CYP4F12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CYP4F12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAACGG
    CYP4F12 Expression
    About this image


    CYP4F12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Liver (Hepatobiliary System)
     
     Spinal Cord (Nervous System)
    CYP4F12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4F12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131459

    UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2
    Tissue specificity: Expressed in small intestine, liver, colon and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F12: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP4F12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP4F12
    QuantiTect SYBR Green Assays in human, mouse, rat CYP4F12
    QuantiFast Probe-based Assays in human, mouse, rat CYP4F12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4F12 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4f141 , 5 cytochrome P450, family 4, subfamily f, polypeptide more1, 5 78.99(n)1
    75.1(a)1
      17 (17.98 cM)5
    643851  NM_001204333.11  NP_001191262.11 
     329050715 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    71(a)
    1 → many
    AADN03027099.1(283-5104)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    62(a)
    59(a)
    many ↔ many
    many ↔ many
    AAWZ02039718(3621-5749)
    2(79856458-79966876)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4f36
    cytochrome P450, family 4, subfamily F, polypeptid...
    47(a)
    1 → many
    12(49851155-49871433) ENSDARG00000053530
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BAS11 BAS1 44.65(n)
    33.42(a)
      817212  NM_128228.3  NP_180239.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02047001 Os02g0204700 46.82(n)
    34.73(a)
      9268939  NM_001185918.1  NP_001172847.1 


    ENSEMBL Gene Tree for CYP4F12 (if available)
    TreeFam Gene Tree for CYP4F12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CYP4F12 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4X12  
    18 SIMAP similar genes for CYP4F12 using alignment to 6 protein entries:     CP4FC_HUMAN (see all proteins):
    CYP4F8    DKFZp761K058    CYP4F11    CYP4F2    DKFZp686F1316    CYP4F3
    CYP4F22    CYP4X1    CYP4B1    CYP4Z1    CYP4A11    CYP4Z2P
    CYP3A43/CYP3A4    CYP4V2    CYP3A5    CYP4A22    CYP2C9    CYP3A4

    CYP4F12 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CYP4F12
    PGOHUM00000259303 PGOHUM00000261260 PGOHUM00000263012


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CYP4F12 (see all 1346)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838256351,2
    --15781885(+) TGGCAA/GAGGGA 1 -- us2k10--------
    rs750835801,2
    F--15781980(+) AGTTTG/CCTTTT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs108541471,2
    C,F,H--15781995(+) TAAATA/GGACAC 1 -- us2k121Minor allele frequency- G:0.11NS EA NA WA CSA 2018
    rs110859671,2
    C,H--15782005(+) CCTTCC/TCTCCT 1 -- us2k1 trp312Minor allele frequency- T:0.07NA WA CSA EA 376
    rs108541481,2
    C,F,H--15782025(+) ATCACC/TCAGGT 1 -- us2k122Minor allele frequency- T:0.11NS EA NA WA CSA 2012
    rs1431866301,2
    --15782075(+) TGGGAC/GGGTGG 1 -- us2k10--------
    rs739268601,2
    C,F--15782091(+) CAGCTT/CTGGGC 1 -- us2k12Minor allele frequency- C:0.11WA 120
    rs72455341,2
    C,F,H--15782098(+) GGGCAT/CTGTGA 1 -- us2k117Minor allele frequency- C:0.06NS EA NA WA CSA 784
    rs1863389691,2
    --15782105(+) GTGATA/GCAGGT 1 -- us2k10--------
    rs1154745411,2
    F--15782135(+) GTGCAC/TGTTAT 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for CYP4F12 (15783567 - 15807984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP4F12 (see all 41):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1095444CNV Deletion17803354
    esv2718240CNV Deletion23290073
    esv1047697CNV Deletion17803354
    dgv627e199CNV Deletion23128226
    esv2660305CNV Deletion23128226
    esv2718238CNV Deletion23290073
    esv2742342CNV Deletion23290073
    esv1195281CNV Deletion17803354
    esv2718241CNV Deletion23290073
    esv2661737CNV Deletion23128226

    Human Gene Mutation Database (HGMD): CYP4F12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP4F12
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4F12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611485    OMIM disorders: --

    3 diseases for CYP4F12:    
    About MalaCards
    warfarin sensitivity    tuberculosis    cerebritis


    CYP4F12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYP4F12
    Human Genome Epidemiology (HuGE) Navigator: CYP4F12 (1 document)

    Export disorders for CYP4F12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CYP4F12 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CYP4F12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression of CYP4F12, a novel human cytochrome P450. (PubMed id 11162607)1, 2, 3, 9 Bylund J.... Oliw E.H. (Biochem. Biophys. Res. Commun. 2001)
    2. cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. (PubMed id 11162645)1, 2, 9 Hashizume T.... Funae Y. (Biochem. Biophys. Res. Commun. 2001)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes. (PubMed id 15548388)1, 9 Cauffiez C....Broly F. (Biochem. Pharmacol. 2004)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    8. Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. (PubMed id 18065749)1 Dhar M....Lasker J.M. (J. Lipid Res. 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 66002 HGNC: 18857 AceView: CYP4F12 Ensembl:ENSG00000186204 euGenes: HUgn66002
    ECgene: CYP4F12 H-InvDB: CYP4F12

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CYP4F12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CYP4F12 gene:
    Search GeneIP for patents involving CYP4F12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP4F12
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CYP4F12  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CYP4F12  
     OriGene MassSpec something-or-other for CYP4F12   OriGene clones in human, mouse for CYP4F12  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYP4F12   OriGene Purified Protein for CYP4F12  
     OriGene ORF clones in mouse, rat for CYP4F12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYP4F12   OriGene Custom Protein Services for CYP4F12  

     
     
     Block miRNA regulation of human, mouse, rat CYP4F12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CYP4F12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4F12 Predesigned siRNA for gene silencing in human, mouse, rat CYP4F12
     QuantiFast Probe-based Assays in human, mouse, rat CYP4F12 QuantiTect SYBR Green Assays in human, mouse, rat CYP4F12
     PCR Arrays including human, mouse, rat CYP4F12 Search Chromatin IP Primers for CYP4F12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP4F12  Search GeneGlobe Interaction Network for CYP4F12
     Regulatory tfbs in CYP4F12 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CYP4F12 GenScript cDNA clones with any tag delivered in your preferred vector for CYP4F12
     GenScript Custom Assay Services for CYP4F12 GenScript Custom overexpressing Cell Line Services for CYP4F12
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CYP4F12 (CP4FC)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CYP4F12 antibodies
     CYP4F12 proteins
     CYP4F12 lysates
     Antibodies for CYP4F12
     See all of Abcam's Antibodies, Kits and Proteins for CYP4F12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CYP4F12
     Antibodies for CYP4F12
     ELISAs for CYP4F12
     CLIAs for CYP4F12



     Browse ESI BIO Cell Lines and PureStem Progenitors for CYP4F12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F12
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CYP4F12
     SwitchGear Promoter luciferase reporter plasmids for CYP4F12
     ThermoFisher Antibodies for CYP4F12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F12
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4F12
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP4F12
     LSBio Antibodies in human, mouse, rat for CYP4F12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYP4F12 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4