CYP4F12 Gene
protein-coding GIFtS: 61
GCID: GC19P015783
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|
cytochrome P450, family 4, subfamily F, polypeptide 12(Previous names: cytochrome P450, subfamily IVF, polypeptide 12 )
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Aliases
for CYP4F12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 4, Subfamily F, Polypeptide 121 2 | | Cytochrome P450, Subfamily IVF, Polypeptide 121 2 | | CYPIVF122 3 | | F22329_12 | | Cytochrome P450 4F122 | | EC 1.14.14.13 |
Export aliases for CYP4F12 gene to outside databasesPrevious GC identifers: GC19M016362 GC19P016177 GC19P015483 GC19P015644 GC19P015352 |
Summaries
for CYP4F12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP4F12:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme iscapable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is partof a cluster of cytochrome P450 genes on chromosome 19. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2Function: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activitymuch lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine
Gene Wiki entry for CYP4F12
|
Genomic Views
for CYP4F12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP4F12 gene promoter:
Max1 Pbx1a Brachyury HSF1 (long) RORalpha1 PPAR-gamma1 HOXA5 HSF1short PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP4F12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.1CYP4F12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P015783: view genomic region
(about GC identifiers)
Start:
|
15,783,567 bp from pter |
End:
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15,807,984 bp from pter |
Size:
|
24,418 bases |
Orientation:
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plus strand |
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Proteins
for CYP4F12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2 (See
protein sequence)Recommended Name: Cytochrome P450 4F12 Size: 524 amino acids; 60270 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Microsome membrane;Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=EAW84492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60389 Q9HCS1Explore the universe of human proteins at neXtProt for CYP4F12: NX_Q9HCS2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCS2
CYP4F12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076433.3
ENSEMBL proteins: ENSP00000448998 ENSP00000448560 ENSP00000446812 ENSP00000428726 ENSP00000449703 ENSP00000430849 ENSP00000447922 ENSP00000321821 ENSP00000449545 Reactome Protein details: Q9HCS2
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CYP4F12 for ontologies About GeneDecksing
CYP4F12 Antibody Products:
Assay Products for CYP4F12: |
Protein
Domains /
Families
for CYP4F12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP4F12 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HCS2ProtoNet protein and cluster: Q9HCS2 1 Blocks protein family: IPB002403 E-class P450 group IV signature
UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2Similarity: Belongs to the cytochrome P450 family |
Function
for CYP4F12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2Function: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activitymuch lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastineCatalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)OEnzyme Number (IUBMB): EC 1.14.14.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP4F12 (NM_023944) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F12 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CYP4F12 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CYP4F12:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cyp4f14):
CYP4F12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CYP4F12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytochrome P450 - arranged by substrate type | | | 2 | Biological oxidations | | | 3 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | | | 4 | Fatty acids | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CYP4F12
1  GeneGo (Thomson Reuters) Pathway for CYP4F12
3  BioSystems Pathways for CYP4F12
5 
Reactome Pathways for CYP4F12
CYP4F12 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4F12
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CYP4F12 (ENSP000003218214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000038 | very long-chain fatty acid metabolic process |
ISS | -- | | GO:0001676 | long-chain fatty acid metabolic process |
ISS | -- | | GO:0003091 | renal water homeostasis |
ISS | -- | | GO:0003095 | pressure natriuresis |
ISS | -- | | GO:0006805 | xenobiotic metabolic process |
TAS | -- |
CYP4F12 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP4F12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP4F12 for compounds About GeneDecksing
 Browse Tocris compounds for CYP4F12
9 HMDB Compounds for CYP4F12 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 10-HETE | 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2) | 167697-52-1 | -- | | 11beta-Hydroxytestosterone | 11beta,17beta-dihydroxyandrost-4-en-3-one | 1816-85-9 | -- | | 13-HETE | 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2) | 151910-72-4 | -- | | 17-HETE | 17-hydroxyeicosatetraenate (see all 3) | -- | -- | | 2beta-Hydroxytestosterone | 2beta,17beta-dihydroxyandrost-4-en-3-one | 10390-14-4 | -- | | 5-Oxo-6-trans-leukotriene B4 | 5-oxo-6E-LTB(,4) (see all 3) | -- | -- | | 6,7-dihydro-12-epi-LTB4 | 6,7-dihydro-12-epi-leukotriene B(,4) (see all 4) | -- | -- | | 6,7-dihydro-5-oxo-12-epi-LTB4 | 6,7-dihydro-5-oxo-12-epi-leukotriene B(,4) (see all 4) | -- | -- | | Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
3 Novoseek chemical compound relationships for CYP4F12 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ebastine |
86.6 |
2 |
15078342 (1) |
| leukotriene b4 |
68.3 |
10 |
17980168 (1), 11162607 (1) |
| arachidonic acid |
50.1 |
3 |
15078342 (1), 11162607 (1) |
Search CenterWatch for drugs/clinical trials and news about CYP4F12 / CP4FC
|
Transcripts
for CYP4F12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP4F12 gene: NM_023944.3 Unigene Cluster for CYP4F12: Cytochrome P450, family 4, subfamily F, polypeptide 12 Hs.131459 [show with all ESTs]Unigene Representative Sequence: AK07543518 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000550308(uc002nbl.3) ENST00000547332 ENST00000547471 ENST00000451750(uc010xoo.2)
ENST00000430608(uc010xop.2) ENST00000548237 ENST00000518629 ENST00000548501
ENST00000549622 ENST00000548435 ENST00000546792 ENST00000550264 ENST00000517734
ENST00000551607 ENST00000324632 ENST00000552048 ENST00000550627 ENST00000546608
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP4F12 (NM_023944) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4F12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F12 |
Additional cDNA sequence: AB035130.1 AB035131.1 AK075435.1 AK304138.1 AK304389.1 AY008841.1 AY358977.1 BC035350.1 11 DOTS entries: DT.455404 DT.100783492 DT.97840225 DT.121503023 DT.100021062 DT.100642514 DT.121503040 DT.101978269 DT.121503041 DT.412029 DT.95321197 24/32 AceView cDNA sequences (see all 32): BM737770 AK074412 AL832171 CD631824 NM_023944 AB035131 AK075435 BM772906 BC034916 BM767149 AY008841 BI759580 CB142482 CD514734 AY358977 AB035130 BM772910 BC035350 BX481676 AA494546 BM738347 CB115664 AA305180 BM737774
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F12 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYP4F12
|
Expression
for CYP4F12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP4F12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAACGG
About this image
See CYP4F12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4F12
SOURCE GeneReport for Unigene cluster: Hs.131459
UniProtKB/Swiss-Prot: CP4FC_HUMAN, Q9HCS2Tissue specificity: Expressed in small intestine, liver, colon and heart
SABiosciences Expression via Pathway-Focused PCR Array including CYP4F12:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP4F12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F12 |
Orthologs
for CYP4F12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYP4F12 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for CYP4F12 (if available)
TreeFam Gene Tree for CYP4F12 (if available) |
Paralogs
for CYP4F12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP4F12 gene
- CYP4F222 CYP4F32 CYP4F22 CYP4F112 CYP46A12 ENSG000002256072 CYP4B12 CYP3A52
- CYP4X12 TBXAS12 CYP3A42 CYP3A432 CYP3A72 CYP4V22 CYP4A222 CYP4A112
- CYP4Z12
18/19 SIMAP similar genes for CYP4F12 using alignment to 7 protein entries: CP4FC_HUMAN (see all proteins)
(see all similar genes):DKFZp761K058 CYP4F11 DKFZp686F1316 CYP4F8 CYP4F2 CYP4F3
CYP4F22 CYP4X1 CYP4B1 CYP4Z1 CYP4A11 CYP4Z2P
CYP3A43/CYP3A4 CYP4V2 CYP3A5 CYP4A22 CYP2C9 CYP3A4
CYP4F12 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CYP4F12
PGOHUM00000259303 PGOHUM00000261260 PGOHUM00000263012
|
Genomic Variants
for CYP4F12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP4F12 (15783567 - 15807984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 37 variations for CYP4F12
15/27 CNVs (see all 27): 50081 89131 30890 89132 53311 78114 89135 78115 89134 37705 50083 67481 89133 29687 8864
9 Indels: 26196 78117 45728 89136 26195 26194 61678 26197 61677
1 Inversion: 43709
Human Gene Mutation Database (HGMD): CYP4F12
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F12 |
|
Disorders
/ Diseases
for CYP4F12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP4F12 for disorders About GeneDecksing
OMIM gene information: 611485
OMIM disorders: --
4  diseases for CYP4F12: About MalaCardswarfarin sensitivity cholesterol tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: CYP4F12 (1 document)
Export disorders for CYP4F12 gene to outside databases
|
Publications
for CYP4F12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP4F12 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CYP4F12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning and expression of CYP4F12, a novel human cytochrome P450. (PubMed id 11162607)1, 2, 3, 9 Bylund J.... Oliw E.H. (2001)
- cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. (PubMed id 11162645)1, 2, 9 Hashizume T.... Funae Y. (2001)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes. (PubMed id 15548388)1, 9 Cauffiez C....Broly F. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. (PubMed id 18065749)1 Dhar M....Lasker J.M. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. (PubMed id 16112640)1 Stark K....Oliw E.H. (2005)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
|
External Searches for CYP4F12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP4F12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP4F12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP4F12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP4F12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYP4F12 gene:
Search GeneIP for patents involving CYP4F12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYP4F12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP4F12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4F12 | | | OriGene Protein Over-expression Lysate for CYP4F12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CYP4F12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4F12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CYP4F12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP4F12 | | OriGene Custom Protein Services for CYP4F12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP4F12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4F12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4F12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP4F12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4F12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4F12 |
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| | | | Search Tocris compounds for CYP4F12 |
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 | | | CYP4F12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F12 |
|  |  |  | | | | ThermoFisher Antibodies for CYP4F12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4F12 |
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