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Aliases for CYP4F11 Gene

Aliases for CYP4F11 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 11 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 11 2 3
  • 3-Hydroxy Fatty Acids Omega-Hydroxylase CYP4F11 3 4
  • Cytochrome P450, Subfamily IVF, Polypeptide 11 2 3
  • Cytochrome P450 4F11 3 4
  • CYPIVF11 3 4
  • EC 1.14.13.194 4
  • EC 1.14.13.- 4

External Ids for CYP4F11 Gene

Previous GeneCards Identifiers for CYP4F11 Gene

  • GC19M016509
  • GC19M015726
  • GC19M015885
  • GC19M015884
  • GC19M016023
  • GC19M015594

Summaries for CYP4F11 Gene

Entrez Gene Summary for CYP4F11 Gene

  • This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F11 Gene

CYP4F11 (Cytochrome P450 Family 4 Subfamily F Member 11) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP4F11 Gene

  • Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).

Gene Wiki entry for CYP4F11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F11 Gene

Genomics for CYP4F11 Gene

Regulatory Elements for CYP4F11 Gene

Promoters for CYP4F11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYP4F11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4F11 Gene

Chromosome:
19
Start:
15,912,367 bp from pter
End:
15,934,867 bp from pter
Size:
22,501 bases
Orientation:
Minus strand

Genomic View for CYP4F11 Gene

Genes around CYP4F11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F11 Gene

Proteins for CYP4F11 Gene

  • Protein details for CYP4F11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBI6-CP4FB_HUMAN
    Recommended name:
    Phylloquinone omega-hydroxylase CYP4F11
    Protein Accession:
    Q9HBI6
    Secondary Accessions:
    • A0A024R7G0
    • A8K059
    • O75254
    • Q96AQ5

    Protein attributes for CYP4F11 Gene

    Size:
    524 amino acids
    Molecular mass:
    60146 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27731.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CYP4F11 Gene

Proteomics data for CYP4F11 Gene at MOPED

Post-translational modifications for CYP4F11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F11 Gene

Antibody Products

No data available for DME Specific Peptides for CYP4F11 Gene

Domains & Families for CYP4F11 Gene

Gene Families for CYP4F11 Gene

Protein Domains for CYP4F11 Gene

Suggested Antigen Peptide Sequences for CYP4F11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBI6

UniProtKB/Swiss-Prot:

CP4FB_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F11: view

Function for CYP4F11 Gene

Molecular function for CYP4F11 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=53.5 mM for 3-hydroxystearate {ECO:0000269 PubMed:18065749}; KM=105.8 mM for 3-hydroxypalmitate {ECO:0000269 PubMed:18065749}; KM=2.4 uM for menaquinone-4 (MK-4) {ECO:0000269 PubMed:24138531}; KM=125 uM for erythromycin {ECO:0000269 PubMed:15364545}; Vmax=830 pmol/min/ng enzyme with erythromycin as substrate {ECO:0000269 PubMed:15364545}; Note=kcat is 0.088 min(-1) with menaquinone-4 (MK-4) as substrate. {ECO:0000269 PubMed:24138531};
UniProtKB/Swiss-Prot CatalyticActivity:
Phylloquinone + NADPH + O(2) = omega-hydroxyphylloquinone + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).

Enzyme Numbers (IUBMB) for CYP4F11 Gene

Gene Ontology (GO) - Molecular Function for CYP4F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
genes like me logo Genes that share ontologies with CYP4F11: view
genes like me logo Genes that share phenotypes with CYP4F11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F11 Gene

Localization for CYP4F11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F11 Gene

Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4F11 Gene COMPARTMENTS Subcellular localization image for CYP4F11 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4F11 Gene

Pathways & Interactions for CYP4F11 Gene

genes like me logo Genes that share pathways with CYP4F11: view

Pathways by source for CYP4F11 Gene

UniProtKB/Swiss-Prot Q9HBI6-CP4FB_HUMAN

  • Pathway: Cofactor degradation; phylloquinone degradation.

Interacting Proteins for CYP4F11 Gene

Gene Ontology (GO) - Biological Process for CYP4F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA,TAS 10964514
genes like me logo Genes that share ontologies with CYP4F11: view

No data available for SIGNOR curated interactions for CYP4F11 Gene

Drugs & Compounds for CYP4F11 Gene

(2) Drugs for CYP4F11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Nutra Activator 27
heme Pharma Agonist 0

(8) Additional Compounds for CYP4F11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
20-Hydroxy-leukotriene B4
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoate
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
79516-82-8
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with CYP4F11: view

Transcripts for CYP4F11 Gene

Unigene Clusters for CYP4F11 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F11 Gene

No ASD Table

Relevant External Links for CYP4F11 Gene

GeneLoc Exon Structure for
CYP4F11
ECgene alternative splicing isoforms for
CYP4F11

Expression for CYP4F11 Gene

mRNA expression in normal human tissues for CYP4F11 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4F11 Gene

This gene is overexpressed in Liver (x20.6).

Protein differential expression in normal tissues from HIPED for CYP4F11 Gene

This gene is overexpressed in Liver (33.6), Gallbladder (14.5), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP4F11 Gene



SOURCE GeneReport for Unigene cluster for CYP4F11 Gene Hs.187393

mRNA Expression by UniProt/SwissProt for CYP4F11 Gene

Q9HBI6-CP4FB_HUMAN
Tissue specificity: Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.
genes like me logo Genes that share expression patterns with CYP4F11: view

Protein tissue co-expression partners for CYP4F11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CYP4F11 Gene

Orthologs for CYP4F11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4F11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4F11 35
  • 98.98 (n)
  • 99.05 (a)
CYP4F11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
CYP4F2 36
  • 79 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4f40 16
Cyp4f15 36
  • 77 (a)
ManyToMany
Cyp4f40 35
  • 78.82 (n)
  • 78.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp4f40 35
  • 79.99 (n)
  • 79.54 (a)
chicken
(Gallus gallus)
Aves CYP4F22 35
  • 66.45 (n)
  • 65.36 (a)
-- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp311a1 37
  • 31 (a)
Cyp312a1 37
  • 34 (a)
Cyp313a2 37
  • 25 (a)
Cyp313a4 37
  • 28 (a)
Cyp313b1 37
  • 26 (a)
Cyp4aa1 37
  • 29 (a)
Cyp4ac1 37
  • 32 (a)
Cyp4ac2 37
  • 31 (a)
Cyp4ac3 37
  • 34 (a)
Cyp4ad1 37
  • 31 (a)
Cyp4ae1 37
  • 33 (a)
Cyp4c3 37
  • 37 (a)
Cyp4d1 37
  • 34 (a)
Cyp4d14 37
  • 37 (a)
Cyp4d2 37
  • 38 (a)
Cyp4d20 37
  • 34 (a)
Cyp4d21 37
  • 31 (a)
Cyp4d8 37
  • 36 (a)
Cyp4e1 37
  • 32 (a)
Cyp4e2 37
  • 32 (a)
Cyp4e3 37
  • 32 (a)
Cyp4g1 37
  • 27 (a)
Cyp4g15 37
  • 35 (a)
Cyp4p1 37
  • 33 (a)
Cyp4p2 37
  • 32 (a)
Cyp4p3 37
  • 35 (a)
Cyp4s3 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea B0331.1 37
  • 35 (a)
C26F1.2 37
  • 33 (a)
F01D5.9 37
  • 34 (a)
F28G4.1 37
  • 34 (a)
Y17G9B.3 37
  • 36 (a)
Y38C9B.1 37
  • 32 (a)
Y5H2B.5 37
  • 37 (a)
Y80D3A.5 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
CSA.3998 36
  • 41 (a)
ManyToMany
CSA.6060 36
  • 38 (a)
ManyToMany
CSA.8060 36
  • 40 (a)
ManyToMany
Species with no ortholog for CYP4F11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F11 Gene

ENSEMBL:
Gene Tree for CYP4F11 (if available)
TreeFam:
Gene Tree for CYP4F11 (if available)

Paralogs for CYP4F11 Gene

Pseudogenes.org Pseudogenes for CYP4F11 Gene

genes like me logo Genes that share paralogs with CYP4F11: view

Variants for CYP4F11 Gene

Sequence variations from dbSNP and Humsavar for CYP4F11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs57519667 - 15,927,301(+) GTGGC(A/G)GCTCC reference, missense
rs8104361 - 15,923,904(+) GGTGC(A/G)GCGCC reference, missense
rs1060463 - 15,914,366(-) GTTTC(A/G)ACCAA reference, missense
rs1060467 -- 15,913,728(-) GACTG(C/T)CCTAC utr-variant-3-prime
rs1471112 -- 15,919,648(+) GTGTC(G/T)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4F11 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
esv2718244 CNV Deletion 23290073
nsv833766 CNV Loss 17160897
esv2671181 CNV Deletion 23128226
nsv911150 CNV Loss 21882294
nsv911151 CNV Loss 21882294
esv2661548 CNV Deletion 23128226
esv21733 CNV Gain+Loss 19812545
nsv821195 CNV Deletion 20802225
esv2718253 CNV Deletion 23290073
esv1311910 CNV Deletion 17803354
esv1040025 CNV Insertion 17803354

Variation tolerance for CYP4F11 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4F11 Gene

HapMap Linkage Disequilibrium report
CYP4F11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F11 Gene

Disorders for CYP4F11 Gene

Relevant External Links for CYP4F11

Genetic Association Database (GAD)
CYP4F11
Human Genome Epidemiology (HuGE) Navigator
CYP4F11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F11

No disorders were found for CYP4F11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4F11 Gene

Publications for CYP4F11 Gene

  1. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. (PMID: 10964514) Cui X. … Strobel H.W. (Genomics 2000) 2 3 4 23 67
  2. The cytochrome P450 4 (CYP4) family. (PMID: 9068972) Simpson A.E. (Gen. Pharmacol. 1997) 2 3
  3. Cytochrome P450-dependent catabolism of vitamin K: I8-hydroxylation catalyzed by human CYP4F2 and CYP4F11. (PMID: 24138531) Edson K.Z. … Rettie A.E. (Biochemistry 2013) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for CYP4F11 Gene

Sources for CYP4F11 Gene

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