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CYP4F11 Gene

protein-coding   GIFtS: 58
GCID: GC19M016023

Cytochrome P450, Family 4, Subfamily F, Polypeptide 11

(Previous names: cytochrome P450, subfamily IVF, polypeptide 11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 4, Subfamily F, Polypeptide 111 2
Cytochrome P450, Subfamily IVF, Polypeptide 111 2
CYPIVF112 3
Cytochrome P450 4F112
EC 1.14.14.13

External Ids:    HGNC: 132651   Entrez Gene: 578342   Ensembl: ENSG000001719037   OMIM: 6115175   UniProtKB: Q9HBI63   

Export aliases for CYP4F11 gene to outside databases

Previous GC identifers: GC19M016509 GC19M015726 GC19M015885 GC19M015884 GC19M015594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4F11 Gene:
This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another
member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4F11 Gene:
CYP4F11 (cytochrome P450, family 4, subfamily F, polypeptide 11) is a protein-coding gene. Diseases associated with CYP4F11 include tuberculosis, and lung cancer. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

Gene Wiki entry for CYP4F11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4F11 gene promoter:
         USF1   Tal-1   USF2   USF-1:USF-2   Ik-3   E47   GATA-1   PPAR-gamma1   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP4F11 promoter sequence
   Search Chromatin IP Primers for CYP4F11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4F11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

CYP4F11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4F11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016023:  view genomic region     (about GC identifiers)

Start:
16,023,177 bp from pter      End:
16,045,677 bp from pter
Size:
22,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CP4FB_HUMAN, Q9HBI6 (See protein sequence)
Recommended Name: Cytochrome P450 4F11  
Size: 524 amino acids; 60146 Da
Cofactor: Heme group (By similarity)
Sequence caution: Sequence=AAC27731.1; Type=Erroneous gene model prediction;
Secondary accessions: O75254 Q96AQ5

Explore the universe of human proteins at neXtProt for CYP4F11: NX_Q9HBI6

Explore proteomics data for CYP4F11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP4F11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122404.1  NP_067010.3  

    ENSEMBL proteins: 
     ENSP00000248041   ENSP00000319859   ENSP00000384588   ENSP00000476972  
    Reactome Protein details: Q9HBI6

    CYP4F11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CYP4F11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4F11
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q9HBI6

    ProtoNet protein and cluster: Q9HBI6

    UniProtKB/Swiss-Prot: CP4FB_HUMAN, Q9HBI6
    Similarity: Belongs to the cytochrome P450 family


    CYP4F11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4FB_HUMAN, Q9HBI6
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Enzyme Number (IUBMB): EC 1.14.14.11

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding TAS10964514
    GO:0070330aromatase activity IEA--
         
    CYP4F11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4F11
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP4F11

    miRNA
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    miRTarBase miRNAs that target CYP4F11:
    hsa-mir-26b-5p (MIRT028889)

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    Search for qRT-PCR Assays for microRNAs that regulate CYP4F11
    SwitchGear 3'UTR luciferase reporter plasmidCYP4F11 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CYP4F11 (NM_021187)
    Sino Biological Human cDNA Clone for CYP4F11
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4FB_HUMAN, Q9HBI6: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome
    membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane2
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    CYP4F11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4F11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Miscellaneous substrates0.00
    cytochrome P4500.74
    Eicosanoids0.00
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP4F11
        cytochrome P450
    metapathway biotransformation


    4 Reactome Pathways for CYP4F11
        Miscellaneous substrates
    Fatty acids
    Eicosanoids
    Synthesis of Leukotrienes (LT) and Eoxins (EX)



    CYP4F11 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F11: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4F11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP4F11 (ENSP000002480414) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    CYP2C18ENSP000002859794STRING: ENSP00000285979
    CYP2C19ENSP000003603724STRING: ENSP00000360372
    CYP2C8ENSP000003603174STRING: ENSP00000360317
    CYP2C9ENSP000002606824STRING: ENSP00000260682
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006954inflammatory response TAS10964514
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process TAS10964514

    CYP4F11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4F11 (CP4FB)

    9 HMDB Compounds for CYP4F11    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    17-HETE17-hydroxyeicosatetraenate (see all 3)----
    2beta-Hydroxytestosterone2beta,17beta-dihydroxyandrost-4-en-3-one 10390-14-4--
    5-Oxo-6-trans-leukotriene B45-oxo-6E-LTB(,4) (see all 3)----
    6,7-dihydro-12-epi-LTB46,7-dihydro-12-epi-leukotriene B(,4) (see all 4)----
    6,7-dihydro-5-oxo-12-epi-LTB46,7-dihydro-5-oxo-12-epi-leukotriene B(,4) (see all 4)----
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP4F11 gene (2 alternative transcripts): 
    NM_001128932.1  NM_021187.3  

    Unigene Cluster for CYP4F11:

    Cytochrome P450, family 4, subfamily F, polypeptide 11
    Hs.187393  [show with all ESTs]
    Unigene Representative Sequence: NM_021187
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248041(uc010eab.1 uc002nbu.2) ENST00000326742 ENST00000402119(uc002nbt.2)
    ENST00000591841
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiTect SYBR Green Assays in human, mouse, rat CYP4F11
      QuantiFast Probe-based Assays in human, mouse, rat CYP4F11

    Additional mRNA sequence: 

    AF236085.1 AK125714.1 AK289424.1 AK309292.1 AL833940.1 BC016853.1 

    5 DOTS entries:

    DT.208225  DT.100751181  DT.101983754  DT.100751182  DT.92431040 

    Selected AceView cDNA sequences (see all 42):

    BM727421 CB305536 AA335970 AF236085 BX112132 CB850568 AK125714 BC016853 
    AW511413 BM907847 BM923448 BF035735 NM_021187 AL833940 AA991369 BU180723 
    BG952218 T56204 BG332763 BU740887 AV748390 BG424018 BE617226 CD630769 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP4F11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP4F11 Expression
    About this image

    CYP4F11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4F11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187393

    UniProtKB/Swiss-Prot: CP4FB_HUMAN, Q9HBI6
    Tissue specificity: Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4F11: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4F11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP4F11 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4f401 , 5 cytochrome P450, family 4, subfamily f, polypeptide more1, 5 78.82(n)1
    78.44(a)1
      17 (17.71 cM)5
    6313041  NM_001101588.11  NP_001095058.11 
     326594835 
    chicken
    (Gallus gallus)
    Aves CYP4F221 cytochrome P450, family 4, subfamily F, polypeptide more 66.45(n)
    65.36(a)
      100859277  XM_003644029.2  XP_003644077.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    62(a)
    many ↔ many
    many ↔ many
    AAWZ02039718(3621-5749)
    2(79856458-79966876)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4f36
    cytochrome P450, family 4, subfamily F, polypeptid...
    48(a)
    1 → many
    12(49851155-49871433) ENSDARG00000053530


    ENSEMBL Gene Tree for CYP4F11 (if available)
    TreeFam Gene Tree for CYP4F11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4F11 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP3A432  CYP3A42  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    17 SIMAP similar genes for CYP4F11 using alignment to 3 protein entries:     CP4FB_HUMAN (see all proteins):
    DKFZp761K058    CYP4F2    CYP4F3    CYP4F8    CYP4F12    CYP4F22
    DKFZp686F1316    CYP4X1    CYP4B1    CYP4Z1    CYP4Z2P    CYP4A11
    CYP3A43/CYP3A4    CYP3A5    CYP4V2    CYP4A22    CYP2E1

    CYP4F11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP4F11
    PGOHUM00000249642


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4F11 (see all 963)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902866861,2
    --15954283(+) ATGACA/GCCGCG 2 -- ds50010--------
    rs796883531,2
    C,F--15954598(+) CAAGAT/AGTTGC 2 -- ds50011Minor allele frequency- A:0.07NA 120
    rs124599331,2
    C,F,A,H--15954603(+) TGTTGT/CGGTAT 2 -- ds500113Minor allele frequency- C:0.45EA NS NA WA CSA 533
    rs1926872111,2
    --15954630(+) AAATAA/GGTCAA 2 -- ds50010--------
    rs739282631,2
    C,F--15954669(+) TAGATC/TCAAAT 2 -- ut312Minor allele frequency- T:0.06WA 120
    rs1849847361,2
    --15954701(+) GATAAA/GGGTGC 2 -- ut310--------
    rs1438819991,2
    --15954704(+) AAAGGC/TGCAAA 2 -- ut310--------
    rs1880815791,2
    C--15954728(+) TCCCAA/GATAAA 2 -- ut310--------
    rs1472694831,2
    --15954756(+) AGATCA/TGAATC 2 -- ut310--------
    rs611753031,2
    C,F--15954805(+) AGCTAC/GAGAAG 2 -- ut315Minor allele frequency- G:0.16NA CSA WA EA 362

    HapMap Linkage Disequilibrium report for CYP4F11 (16023177 - 16045677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP4F11 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671181CNV Deletion23128226
    esv1311910CNV Deletion17803354
    nsv821195CNV Deletion20802225
    esv2718253CNV Deletion23290073
    esv2718244CNV Deletion23290073
    esv2661548CNV Deletion23128226
    esv1040025CNV Insertion17803354
    nsv833766CNV Loss17160897
    nsv911150CNV Loss21882294
    nsv911151CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611517    OMIM disorders: --

    2 diseases for CYP4F11:    About MalaCards
    tuberculosis    lung cancer


    CYP4F11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYP4F11
    Human Genome Epidemiology (HuGE) Navigator: CYP4F11 (3 documents)

    Export disorders for CYP4F11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4F11 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CYP4F11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. (PubMed id 10964514)1, 2, 3, 9 Cui X.... Strobel H.W. (Genomics 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The cytochrome P450 4 (CYP4) family. (PubMed id 9068972)1, 3 Simpson A.E. (Gen. Pharmacol. 1997)
    7. Cytochrome P450-dependent catabolism of vitamin K: I8-hydroxylation catalyzed by human CYP4F2 and CYP4F11. (PubMed id 24138531)1 Edson K.Z....Rettie A.E. (Biochemistry 2013)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57834 HGNC: 13265 AceView: CYP4F11 Ensembl:ENSG00000171903 euGenes: HUgn57834
    ECgene: CYP4F11 H-InvDB: CYP4F11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP4F11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4F11 gene:
    Search GeneIP for patents involving CYP4F11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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