Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


CYP4B1 Gene

protein-coding   GIFtS: 60

GC01P047264
cytochrome P450, family 4, subfamily B, polypeptide 1
(Previous names: cytochrome P450, subfamily IVB, polypeptide 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for CYP4B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
cytochrome P450, family 4, subfamily B, polypeptide 11 2     cytochrome P450 4B12
cytochrome P450, subfamily IVB, polypeptide 11 2     microsomal monooxygenase2
Cytochrome P450-HP2 3     P-450HP2
CYPIVB12 3     EC 1.14.14.13

External Ids:    HGNC: 26441   Entrez Gene: 15802   Ensembl: ENSG000001429737   UniProtKB: P135843   

Search outside databases for aliases for CYP4B1 gene

Previous GC identifers: GC01P046958 GC01P046221 GC01P046651 GC01P046634 GC01P046976 GC01P047037

Summaries
for CYP4B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for CYP4B1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown
to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two
transcript variants encoding slightly different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP4B1

Genomic Views
for CYP4B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CYP4B1 gene upstream (promoter) region "":
Egr-1   GATA-1   CHOP-10   C/EBPalpha   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MIF-1   USF1   MRF-2   

Epigenetics:
"" Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP4B1 ""

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34-p12   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34-p12

CYP4B1 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047264:  view genomic region     (about GC identifiers)

Start:
 47,264,670 bp from pter
End:
 47,285,085 bp from pter
Size:
 20,416 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

Proteins
for CYP4B1 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584 (See protein sequence)
Recommended Name: Cytochrome P450 4B1  
Size: 511 amino acids; 58991 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: Q1HBI2 Q8TD85 Q8WWF2 Q8WWU9 Q8WWV0
Alternative splicing: 2 isoforms:  P13584-1   P13584-2   

REFSEQ proteins (2 alternative transcripts): 
NP_000770.2  NP_001093242.1  


ENSEMBL proteins: 
ENSP00000271153 ENSP00000360991 ENSP00000360987 ENSP00000400413 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Enzo Life Sciences proteins for CYP4B1
""HuPro® and/or Recombinant Proteins from Abnova for CYP4B1 ""
"" Origene Purified Recombinant Human Protein: CYP4B1
""Novus Biologicals Protein for CYP4B1  ""
Novus Biologicals Lysate for CYP4B1
""Browse Sino Biological Recombinant Proteins  ""

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane EXP15006160
GO:0005792 microsome IEA--
GO:0016020 membrane IEA--
GO:0019898 extrinsic to membrane ----
About this table

"" CYP4B1 for ontologies           About GeneDecksing



Antibodies for CYP4B1: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for CYP4B1
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (CYP4B1)
""Browse Origene Antibodies ""
""Novus Biologicals Antibodies for CYP4B1
""Browse antibodies at Epitomics

Assays for CYP4B1: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Enzo Life Sciences assays for CYP4B1

Protein Domains/
Families
for CYP4B1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

  User Feedback
"" CYP4B1 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001128 Cyt_P450
 IPR017973 Cyt_P450_C
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P13584

ProtoNet protein and cluster: P13584

UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
Similarity: Belongs to the cytochrome P450 family

Gene Function
for CYP4B1 gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
About This Section

  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (CYP4B1)
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CYP4B1
Origene shRNA RFP (see all 2): CYP4B1
Origene basic RS shRNA (see all 2): CYP4B1

""Applied Biosystems Silencer® siRNAs for CYP4B1
""Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CYP4B1
Sigma-Aldrich shRNA for CYP4B1
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): CYP4B1
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CYP4B1
Origene untagged cDNA clones in CMV expression vector (see all 3): CYP4B1
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
steroids, fatty acids, and xenobiotics
Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs,
pesticides, and carcinogens
Enzyme Number (IUBMB): EC 1.14.14.1 

Genatlas biochemistry entry for CYP4B1:
cytochrome P450,subfamily IVB1,expressed in lung

5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0004497 monooxygenase activity IEA--
GO:0005506 iron ion binding ----
GO:0008144 drug binding ----
GO:0009055 electron carrier activity IEA--
GO:0018585 fluorene oxygenase activity ----
About this table

"" CYP4B1 for ontologies           About GeneDecksing

Animal Models: 2 MGI phenotypic alleles "" for Cyp4b1 (no phenotypes)


"" CYP4B1 for phenotypes           About GeneDecksing

Pathways & Interactions
for CYP4B1 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
About This Section

  User Feedback
"" CYP4B1 for pathways           About GeneDecksing

5 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  CYP4B1  (Your Favorite Gene powered by Ingenuity)
  ""  Tryptophan Metabolism
Fatty Acid Metabolism
Arachidonic Acid Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Linoleic Acid Metabolism

"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4B1

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006725 cellular aromatic compound metabolic process ----
GO:0018879 biphenyl metabolic process ----
GO:0018917 fluorene metabolic process ----
GO:0042738 exogenous drug catabolic process ----
GO:0055114 oxidation reduction IEA--
About this table

"" CYP4B1 for ontologies           About GeneDecksing


Drugs & Compounds
for CYP4B1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

  User Feedback
"" CYP4B1 for compounds           About GeneDecksing

"" Enzo Life Sciences drugs & compounds for CYP4B1
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for CYP4B1
10/38 ""Novoseek chemical compound relationships for CYP4B1 gene (see all 38 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
4-ipomeanol 43.83 14 8248926 (5), 9650611 (3), 7503758 (2), 10917203 (2) (see all 6)
2-aminoanthracene 21.88 8 9650611 (4), 11857036 (2), 7503758 (1), 10917203 (1)
2-aminofluorene 13.11 6 8248926 (1), 7894498 (1), 18713828 (1), 12639503 (1) (see all 6)
heme 11.86 12 11669629 (4), 9737862 (3), 12859977 (3), 17880109 (2)
3,3'-dichlorobenzidine 8.41 3 9310344 (3)
2-naphthylamine 7.18 3 9310344 (2), 18713828 (1)
lauric acid 5.56 3 9737862 (1), 12639503 (1), 11396967 (1)
toluene 4.31 4 9726784 (4)
3-methyleneindolenine 3.30 1 20187624 (1)
12-hydroxydodecanoic acid 3.18 1 9737862 (1)
About this table

1 PharmGKB drug compound relationship for CYP4B1 gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
xenobioticsGN  12142726
About this table


Transcripts
for CYP4B1 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
About This Section

  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (CYP4B1)
""Applied Biosystems Silencer® siRNAs:  NM_000779  NM_001099772  
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CYP4B1
Origene shRNA RFP (see all 2): CYP4B1
Origene basic RS shRNA (see all 2): CYP4B1

""Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CYP4B1
Sigma-Aldrich shRNA for CYP4B1
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate CYP4B1: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_000779  NM_001099772  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): CYP4B1
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CYP4B1
Origene untagged cDNA clones in CMV expression vector (see all 3): CYP4B1
Primers:"" Origene genome-wide validated SYBR primer pairs: CYP4B1
""SABiosciences RT2 qPCR Primer Assay for CYP4B1: PPH01269A ""

REFSEQ mRNAs for CYP4B1 gene (2 alternative transcripts): 

NM_000779.3  NM_001099772.1  

Additional cDNA sequence: 

AF491285.1 AK225576.1 AK225578.1 AK300921.1 AK300941.1 AK307715.1 AK313170.1 AY064484.1 
AY064485.1 AY064486.1 AY151048.1 AY151049.1 BC017758.1 J02871.1 X16699.1 

7 DOTS entries:

DT.111100  DT.101980207  DT.100776898  DT.97826031  DT.97837690  DT.121455988  DT.97762269 

24/96 AceView cDNA sequences (see all 96 ):

BM977024 AY064485 CB306078 BU684574 CD171911 BQ881161 AF491285 BM980704 
BQ029538 BM980737 BM982410 BQ045121 AY064486 AY151048 CD519012 BM975516 
BM976673 BC017758 BQ029986 AY151049 AA036869 BM977596 CD013981 BF001158 

"" highest scoring ESTs for CYP4B1:

J02871 AA036869 AA193653 AA291484 AA404692 AA411450 AA411581 AA477217 AA807949 AF491285 

Unigene Cluster for CYP4B1:

Cytochrome P450, family 4, subfamily B, polypeptide 1
Hs.436317  [show with all ESTs]
Unigene Representative Sequence: NM_001099772


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4B1 (see all 6 )

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:                          -           -                                                                                 
SP2:                          -           -                       -                                                         
SP3:                          -           -                                                                                 
SP4:                          -     -     -                                                                                 
SP5:                          -     -                                                                                       

About this scheme

ECgene alternative splicing isoforms for CYP4B1

8 Ensembl transcripts including schematic representations:
ENST00000271153  ENST00000371923  ENST00000371919  ENST00000497005  ENST00000468637  ENST00000481248  
ENST00000464439  ENST00000452782  

Expression
for CYP4B1 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
About This Section

  User Feedback

CYP4B1 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for CYP4B1

1""  / 2""  / 3""

4 probe-sets matching CYP4B1 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1667_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 J02871 1.00 1.00 1.00 1
210096_at2, 3 U133-A 1 0.91 1.00 -- -- J02871 1.00 1.00 1.00 1
1555497_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
210096_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

"" CYP4B1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTTATGGCTG

SOURCE GeneReport for Unigene cluster: Hs.436317

Expression variation in blood from EXPOLDB for CYP4B1

UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
Tissue specificity: Detected in the liver and lung (at protein level)

Primers:"" Origene genome-wide validated SYBR primer pairs: CYP4B1 ""
""SABiosciences RT2 qPCR Primer Assay for CYP4B1: PPH01269A ""

Orthologs
for CYP4B1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

  User Feedback
Orthologs for CYP4B1 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC6084521   -- similar to cytochrome P450, family 4, subfamily B, more 87.28(n)
86.89(a)		 608452  XM_845151.1  XP_850244.1 
chimpanzee
(Pan troglodytes)		 LOC4565571   -- similar to Cytochrome P450, family 4, subfamily B, more 99.4(n)
98.71(a)		 456557  XM_513140.2  XP_513140.2 
cow
(Bos taurus)		 CYP4B11   -- cytochrome P450, family 4, subfamily B, polypeptide more 84.67(n)
82.78(a)		 540149  NM_001076202.1  NP_001069670.1 
rat
(Rattus norvegicus)		 Cyp4b11   -- cytochrome P450, family 4, subfamily b, polypeptide more 86.04(n)
85.91(a)		 24307  NM_016999.2  NP_058695.2 
mouse
(Mus musculus)		 Cyp4b15
Cyp4b11		 4 (49.50 cM)5
 cytochrome P450, family 4, subfamily b, polypeptide more1, 5 85.71(n)1
85.13(a)1		 131201  NM_007823.21  NP_031849.11 
 AK0788825  AK1438905  (see all 9)
About this table        Species with no ortholog for CYP4B1

ENSEMBL Gene Tree for CYP4B1

Paralogs
for CYP4B1 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  User Feedback
Paralogs for CYP4B1 gene
CYP4F222  CYP4F112  CYP4F22  CYP4F32  CYP4F82  CYP46A12  LOC3885142  CYP3A52  
CYP4X12  TBXAS12  CYP3A432  CYP3A42  CYP3A72  CYP4V22  CYP4A222  CYP4A112  
CYP4Z12  CYP4F122  

"" CYP4B1 for paralogs           About GeneDecksing


Genomic Variants
for CYP4B1 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
About This Section

  User Feedback
10/81 NCBI SNPs in CYP4B1 are shown (see all 81 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 87)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
""
rs22978101,2
C,F,O,A,H47280859(-) AGGGCC/TATGCA 4 I M mis1 ref1 ese3""32Minor allele frequency- T:0.32EA NS NA WA 3782""
""
rs6322331,2
C,F,A,H45379819(-) GGCTCA/GCAATG 2 -- ng51""25Minor allele frequency- G:0.30MN NS EA NA 2975""
""
rs8374031,2
C,F,A,H45379048(-) TGATAC/AGCCAT 2 -- ng51""16Minor allele frequency- A:0.13NS EA NA WA 816""
""
rs46464871,2
C,F,A,H47279175(+) AAGCTC/TGGGAG 4 R W ref1 mis1 ese3""38Minor allele frequency- T:0.21NS EA NA MN WA 4490""
--
rs46464911,2
C,F,A,H47280884(+) AGCATC/TGTTGT 4 R C ref1 mis1 ese3""26Minor allele frequency- T:0.21EA NA NS WA 1878""
""
rs6321331,2
C,F,A,H45380109(-) AACAGT/GCAATG 2 -- ng51""14Minor allele frequency- G:0.13MN NS EA NA 798""
""
rs6326451,2
C,F,O,A45379747(-) CCAGGC/TCAGAA 2 -- ng51""24Minor allele frequency- N:0.00EA MN NS NA WA 2994""
""
rs37661961,2
C,F,A47284526(-) GGGAGG/TTCACA 2 -- ut31 ese3""11Minor allele frequency- T:0.14EA NA NS WA 1944""
--
rs37661951,2
C,F,A47284572(-) GGGGGC/TCCCAA 2 -- ut31 ese3""9Minor allele frequency- T:0.16NA NS 402""
""
rs6344311,2
C,F,H45379305(-) aacagC/Tggaag 2 -- ng51""15Minor allele frequency- T:0.14NS EA NA WA 734""
About this table

HapMap Linkage Disequilibrium images for CYP4B1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
      Database of Genomic Variants (DGV) variations for CYP4B1: --

Disorders & Mutations
for CYP4B1 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  User Feedback
"" CYP4B1 for disorders           About GeneDecksing

OMIM: 124075

10/18 ""Novoseek disease relationships for CYP4B1 gene (see all 18 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
bladder cancer 11.31 11 18713828 (6), 11062028 (4), 9310344 (1)
corneal neovascularization 5.69 3 16009741 (2), 17991614 (1)
hypoxic 2.50 4 15048876 (3), 10336559 (1)
lung tumor 2.20 2 8313365 (2)
gene fusion 2.17 2 11857036 (1), 10830728 (1)
herpes simplex 1.93 3 10830728 (2), 11857036 (1)
gliosarcoma 1.82 1 11857036 (1)
mutagenic effect 1.47 1 7503758 (1)
keratitis 1.10 1 16009741 (1)
glioma 0.98 2 9650611 (2)
About this table

Locus Specific Mutation Databases: CYP4B1
Human Gene Mutation Database: CYP4B1
Genetic Association Database: CYP4B1
Human Genome Epidemiology Navigator: CYP4B1 (7 documents)

Medical News
for CYP4B1 gene

(Possibly Related Articles in Doctor's Guide)
About This Section

  User Feedback		   --

Publications
for CYP4B1 gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

  User Feedback		21/56 PubMed articles for CYP4B1 gene (see all 56 ):

Search for CYP4B1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

  User Feedback
 ANDOR
Aliases
Disorders
Search String
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing CYP4B1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

  User Feedback
Entrez Gene: 1580 HGNC: 2644 AceView: CYP4B1 Ensembl:ENSG00000142973 euGenes: HUgn1580
ECgene: CYP4B1 H-InvDB: CYP4B1

Other Databases showing CYP4B1 gene

(According to HUGE)
About This Section

  User Feedback		   --

Specialized Databases showing CYP4B1 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  User Feedback
NameDescription
ATLAS Chromosomes in Cancer entry for CYP4B1 Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp4b1.htm
NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp4b1/

Intellectual Property
for CYP4B1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section

  User Feedback		Patent Information for CYP4B1 gene: ""
Search GeneIP for patents involving CYP4B1

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


Services
for CYP4B1 gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

  User Feedback		""
""
Products for CYP4B1:
"" TaqMan ® Gene Expression Assays
"" TaqMan ® Genotyping Assays
 "" Free SNP selection tool

""
"" Millipore Custom Antibody & Bulk Services
"" Millipore Preclinical / Clinical Development Services
"" Millipore Immunoassay Services
"" Millipore Target Screening & Profiling Services

""
"" Predesigned and custom siRNAs for CYP4B1"" Antibodies for CYP4B1
"" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
"" Lentivirus-delivered shRNAs for CYP4B1"" Browse small molecules at Sigma-Aldrich
"" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
"" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


 ""  ""
"" Antibodies  "" Primer Pairs  
"" Cell Culture Products  "" ELISAs  
"" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
"" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
"" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
"" Recombinant & Natural Proteins  

"" Recombinant Proteins (CYP4B1)
"" Antibodies (CYP4B1)
"" Chimera RNAi (CYP4B1)
"" Custom Service for Mouse Mab
"" Custom Service for Rabbit Pab from Full-length Protein


""""""""
"" Search for Antibodies & Assays

"" Tagged/untagged cDNA clones
"" Validated SYBR primer pairs
"" Purified proteins from HEK293T cells
"" Western blot validated antibodies
"" shRNA in GFP-retroviral vector
"" Custom immunoassay development
"" Search Tocris compounds for CYP4B1
"" Regulatory tfbs in CYP4B1 upstream (promoter) region
"" Search Chromatin IP Primers for CYP4B1
"" Search DNA Methylation qPCR Primer Assays for CYP4B1
"" RT2 qPCR Primer Assay for CYP4B1
"" Search GNC Networks for CYP4B1
"" Search for microRNAs that regulate CYP4B1
""""""""
"" Assays/Drugs/Proteins for CYP4B1
"" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
"" Novus Tissue Slides
"" Antibodies for CYP4B1
"" Proteins for CYP4B1
"" Lysates for CYP4B1
"" Browse antibodies at Epitomics
"" Browse Sino Biological Proteins and Antibodies
"" Browse Sino Biological cDNA Clones
"" Antibodies/Proteins Production Services
"" Rabbit Monoclonal Antibody Platform
"" Bulk Purchasing
  User Feedback        

GeneCards Homepage - Last full update: 20 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

View Random Gene

Category
acyl-CoA synthetase family member 3
GIFtS Group
The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
CYP4B1 gene at Home site.
hostname: server5.xennexinc.com db build: 72 index build: 72d solr: 1.4