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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP4B1 Gene

protein-coding   GIFtS: 63
GCID: GC01P047264

cytochrome P450, family 4, subfamily B, polypeptide 1

(Previous names: cytochrome P450, subfamily IVB, polypeptide 1 )
 Explore 13 diseases affiliated with
CYP4B1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYP4B1    

Aliases
for CYP4B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome P450, Family 4, Subfamily B, Polypeptide 11 2     EC 1.14.14.13 8
Cytochrome P450, Subfamily IVB, Polypeptide 11 2     P-450HP2
Cytochrome P450-HP2 3     Cytochrome P450 4B12
CYPIVB12 3     Microsomal Monooxygenase2

External Ids:    HGNC: 26441   Entrez Gene: 15802   Ensembl: ENSG000001429737   OMIM: 1240755   UniProtKB: P135843   

Export aliases for CYP4B1 gene to outside databases

Previous GC identifers: GC01P046958 GC01P046221 GC01P046651 GC01P046634 GC01P046976 GC01P047037 GC01P045380


Summaries
for CYP4B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP4B1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown
to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two
transcript variants encoding slightly different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP4B1


Genomic Views
for CYP4B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP4B1 gene promoter:
         Max1   FOXD1   AP-4   Nkx5-1   Arnt   AREB6   POU2F1   POU2F1a   Zic3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP4B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP4B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34-p12   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34-p12

CYP4B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4B1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047264:  view genomic region     (about GC identifiers)

Start:
 47,223,510 bp from pter      End:
 47,285,085 bp from pter
Size:
 61,576 bases      Orientation:
 plus strand

Proteins
for CYP4B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584 (See protein sequence)
Recommended Name: Cytochrome P450 4B1  
Size: 511 amino acids; 58991 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: Q1HBI2 Q8TD85 Q8WWF2 Q8WWU9 Q8WWV0
Alternative splicing: 2 isoforms:  P13584-1   P13584-2   

Explore the universe of human proteins at neXtProt for CYP4B1: NX_P13584

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13584

    • 4 DME Specific Peptides for CYP4B1 (P13584)
     TLMKCTFG  VWPDPEVFD  GPRNCIGQQFAM  QHRKLLTPGFHYDVLKPYVA 

    CYP4B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000770.2  NP_001093242.1  

    ENSEMBL proteins: 
     ENSP00000433367   ENSP00000360991   ENSP00000271153   ENSP00000443212   ENSP00000433068  
     ENSP00000360987   ENSP00000438995   ENSP00000400413   ENSP00000437670  
    Reactome Protein details: P13584
    Human Recombinant Protein Products: 
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    Uscn Proteins for CYP4B1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----


    CYP4B1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CYP4B1

    Protein Domains /
    Families
    for CYP4B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYP4B1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P13584

    ProtoNet protein and cluster: P13584

    UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
    Similarity: Belongs to the cytochrome P450 family


    Function
    for CYP4B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
    an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
    steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs,
    pesticides, and carcinogens

         Genatlas biochemistry entry for CYP4B1:
    cytochrome P450,subfamily IVB1,expressed in lung

    Enzyme Number (IUBMB): EC 1.14.14.11 2

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    Inhib. RNA
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0008144drug binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----


    CYP4B1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CYP4B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type1.00
    		cytochrome P4500.73
    		Phase 1 - Functionalization of compounds0.74
    2Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    3Fatty acids
    		Fatty acids1.00
    4Metabolism
    		Metabolism1.00
    5Nuclear receptors in lipid metabolism and toxicity
    		Nuclear receptors in lipid metabolism and toxicity1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for CYP4B1 
        cytochrome P450
    Nuclear receptors in lipid metabolism and toxicity
    metapathway biotransformation

    5        Reactome Pathways for CYP4B1
        Cytochrome P450 - arranged by substrate type
    Fatty acids
    Metabolism
    Biological oxidations
    Phase 1 - Functionalization of compounds



    CYP4B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4B1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CYP4B1 (P135843 ENSP000003609914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DFFAO002733, ENSP000003662374I2D: score=1 STRING: ENSP00000366237
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006725cellular aromatic compound metabolic process ----
    GO:0006805xenobiotic metabolic process TAS--
    GO:0018879biphenyl metabolic process IEA--
    GO:0018917fluorene metabolic process IEA--
    GO:0042738exogenous drug catabolic process IEA--


    CYP4B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYP4B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP4B1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYP4B1

    10/49 HMDB Compounds for CYP4B1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    1 DrugBank Compound for CYP4B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MidazolamDea No. 2884 (see all 4)59467-70-8enzymesubstrate11996015

    5 Novoseek chemical compound relationships for CYP4B1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-ipomeanol 91.7 9 9650611 (2), 10830728 (1), 10917203 (1), 12639503 (1)
    2-aminofluorene 84.7 8 11062028 (1), 7894498 (1), 18713828 (1), 11396967 (1) (see all 5)
    3-methylindole 76.9 1 20187624 (1)
    2-aminoanthracene 73 4 9650611 (2), 10917203 (1)
    lauric acid 63.6 2 11396967 (1), 12639503 (1)

    2 PharmGKB related drug/compound annotations for CYP4B1 gene
    Drug/compound PharmGKB Annotation
    docetaxelCA  
    thalidomideCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CYP4B1 / CP4B1 

    Transcripts
    for CYP4B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYP4B1 gene (2 alternative transcripts): 
    NM_000779.3  NM_001099772.1  

    Unigene Cluster for CYP4B1:

    Cytochrome P450, family 4, subfamily B, polypeptide 1
    Hs.436317  [show with all ESTs]
    Unigene Representative Sequence: NM_001099772
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546128 ENST00000413093 ENST00000534708 ENST00000371923(uc001cqn.4 uc001cqm.4 uc009vym.3 uc010omk.2)
    ENST00000271153 ENST00000529715(uc009vyl.1) ENST00000464439 ENST00000371919
    ENST00000526297 ENST00000452782(uc010oml.1) ENST00000468637 ENST00000481248
    ENST00000497005

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF491285.1 AK225576.1 AK225578.1 AK300921.1 AK300941.1 AK307715.1 AK313170.1 AY064484.1 
    AY064485.1 AY064486.1 AY151048.1 AY151049.1 BC017758.1 J02871.1 X16699.1 

    7 DOTS entries:

    DT.111100  DT.101980207  DT.100776898  DT.97826031  DT.97837690  DT.121455988  DT.97762269 

    24/96 AceView cDNA sequences (see all 96):

    BU684574 BQ029538 CD171911 BM976673 BC017758 BQ029986 AY151049 AA036869 
    BM977596 CD013981 BF001158 BM975516 AY151048 BQ045121 CD519012 BM980737 
    BM982410 BM977024 CB306078 AY064485 BQ881161 AY064486 AF491285 BM980704 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP4B1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                          -           -                                                                                 
    SP2:                          -           -                       -                                                         
    SP3:                          -           -                                                                                 
    SP4:                          -     -     -                                                                                 
    SP5:                          -     -                                                                                       


    ECgene alternative splicing isoforms for CYP4B1

    Expression
    for CYP4B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP4B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTATGGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CYP4B1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CYP4B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP4B1

    SOURCE GeneReport for Unigene cluster: Hs.436317

    UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
    Tissue specificity: Detected in the liver and lung (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP4B1: 
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              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CYP4B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4B1 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7719741 cytochrome P450 4B1-like 65.17(n)
    59.71(a)    		   771974  XM_001235179.2  XP_001235180.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 6)    		 --
    		 54(a)
    54(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 GL343249.1(1946154-1981895)
    GL343249.1(1884522-1908212)
    zebrafish
    (Danio rerio)    		 Actinopterygii cyp4t81 cytochrome P450, family 4, subfamily T, polypeptide more 57.94(n)
    52.8(a)    		   387527  NM_199216.1  NP_954686.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYP715A11 cytochrome P450, family 715, subfamily A, polypeptide more 43.61(n)
    30.36(a)    		   835316  NM_124619.2  NP_200053.2 
    rice
    (Oryza sativa)    		 Liliopsida Os02g08241001 hypothetical protein 45.9(n)
    30.91(a)    		   4331202  NM_001055108.1  NP_001048573.1 


    ENSEMBL Gene Tree for CYP4B1 (if available)
    TreeFam Gene Tree for CYP4B1 (if available) 

    Paralogs
    for CYP4B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP4B1 gene
    CYP4F222  CYP4F32  CYP4F22  CYP4F112  CYP46A12  ENSG000002256072  CYP3A52  CYP4X12  
    TBXAS12  CYP3A432  CYP3A42  CYP3A72  CYP4V22  CYP4A222  CYP4A112  CYP4F122  
    CYP4Z12  
    17 SIMAP similar genes for CYP4B1 using alignment to 9 protein entries:     CP4B1_HUMAN (see all proteins):
    CYP4X1    CYP4Z1    CYP4A11    CYP4F8    CYP4F22    CYP4Z2P
    CYP4F12    CYP4F11    CYP4F3    CYP4F2    DKFZp761K058    CYP4A22
    CYP3A5    CYP3A4    CYP3A43    CYP46A1    CYP4V2

    CYP4B1 for paralogs           About GeneDecksing



    Genomic Variants
    for CYP4B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/548 NCBI SNPs in CYP4B1 are shown (see all 548)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs75543401,2
    		C,--45378549(+) ttcttC/Ttcagc 2 -- us2k10--------
    rs66773501,2
    		C,F,H,--45378837(+) ATGGTG/ACACTC 2 -- us2k115Minor allele frequency- A:0.06NS EA NA WA 1888
    rs455447331,2
    		C,--45378851(+) GTCTCG/CATCCT 2 -- us2k15Minor allele frequency- C:0.01NS 160
    rs455821311,2
    		C,F,--45379292(+) TTTTTG/TCTCTG 2 -- us2k15Minor allele frequency- T:0.01NS 186
    rs455686311,2
    		C,F,--45379327(+) TCTCTC/TGCACT 2 -- us2k16Minor allele frequency- T:0.01NS WA 298
    rs455859371,2
    		F--45379506(+) ACCCT-/TCCCCA 2 -- us2k15Minor allele frequency- T:0.01NS 182
    rs455200361,2
    		C,F,--45379635(+) TGGCTC/ACATCC 2 -- us2k17Minor allele frequency- A:0.02NS WA 302
    rs1133515591,2
    		F--45380379(+) CCCAGC/TTTCCT 4 S syn11Minor allele frequency- T:0.50CSA 4
    rs556420001,2
    		C--45380544(+) GCCCTC/TGAGGT 4 L syn11Minor allele frequency- T:0.00NA 3844
    rs37662101,2
    		C,F,H,--45380882(-) GTACTA/GTCCAG 2 -- int111Minor allele frequency- G:0.01NS EA NA 690

    HapMap Linkage Disequilibrium report for CYP4B1 (47223510 - 47285085 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYP4B1: --
    Human Gene Mutation Database (HGMD): CYP4B1

    Locus Specific Mutation Databases (LSDB): CYP4B1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4B1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP4B1

    Disorders / Diseases
    for CYP4B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYP4B1 for disorders           About GeneDecksing

    OMIM gene information: 124075    OMIM disorders: --

    13 diseases for CYP4B1:    About MalaCards
    cholesterol    hearing loss    chronic lymphocytic leukemia    herpes simplex
    lymphocytic leukemia    hepatocellular carcinoma    nasopharyngitis    leukemia
    prostate cancer    prostatitis    tuberculosis    carcinoma
    mycobacterium tuberculosis

    6 Novoseek disease relationships for CYP4B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder tumors 36.6 2 11062028 (2)
    bladder cancer 31.4 6 18713828 (5), 11062028 (1)
    glioma 13 1 9650611 (1)
    cancer lung 0 1 8313365 (1)
    tumors 0 7 9650611 (2), 11062028 (1), 10917203 (1), 11059566 (1)
    cancer 0 1 9650611 (1)

    Genetic Association Database (GAD): CYP4B1
    Human Genome Epidemiology (HuGE) Navigator: CYP4B1 (11 documents)

    Export disorders for CYP4B1 gene to outside databases

    Publications
    for CYP4B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP4B1 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with CYP4B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. (PubMed id 12142726)1, 2, 4, 9 Lo-Guidice J.-M.... Broly F. (2002)
    2. Human CYP4B1 gene in the japanese population analyzed by denaturing HPLC. (PubMed id 15499177)1, 4 Hiratsuka M....Mizugaki M. (2004)
    3. cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression. (PubMed id 2298205)1, 2 Yokotani N.... Fujii-Kuriyama Y. (1990)
    4. Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. (PubMed id 2574990)1, 2 Nhamburo P.T.... Kimura S. (1989)
    5. Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. (PubMed id 7894498)1, 9 McKinnon R.A....McManus M.E. (1994)
    6. Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype. (PubMed id 18713828)1, 9 Sasaki T....Hiratsuka M. (2008)
    7. CYP4B1 is a possible risk factor for bladder cancer in humans. (PubMed id 11062028)1, 9 Imaoka S....Funae Y. (2000)
    8. Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. (PubMed id 8313365)1, 9 Czerwinski M....Gonzalez F.J. (1994)
    9. Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids. (PubMed id 15006160)1, 9 Ashkar S....Laniado-Schwartzman M. (2004)
    10. Covalent linkage of prosthetic heme to CYP4 family P450 enzymes. (PubMed id 11669629)1, 9 Henne K.R....Rettie A.E. (2001)

    External Searches for CYP4B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYP4B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1580 HGNC: 2644 AceView: CYP4B1 Ensembl:ENSG00000142973 euGenes: HUgn1580
    ECgene: CYP4B1 H-InvDB: CYP4B1

    Other Databases showing CYP4B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP4B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP4B1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP4B1 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp4b1.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp4b1/

    Intellectual Property
    for CYP4B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP4B1 gene:
    Search GeneIP for patents involving CYP4B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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