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CYP4B1 Gene

protein-coding   GIFtS: 67
GCID: GC01P047227

Cytochrome P450, Family 4, Subfamily B, Polypeptide 1

(Previous names: cytochrome P450, subfamily IVB, polypeptide 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome P450, Family 4, Subfamily B, Polypeptide 11 2     EC 1.14.14.13 8
Cytochrome P450, Subfamily IVB, Polypeptide 11 2     P-450HP2
Cytochrome P450-HP2 3     Cytochrome P450 4B12
CYPIVB12 3     Microsomal Monooxygenase2

External Ids:    HGNC: 26441   Entrez Gene: 15802   Ensembl: ENSG000001429737   OMIM: 1240755   UniProtKB: P135843   
ORGUL members:         

Export aliases for CYP4B1 gene to outside databases

Previous GC identifers: GC01P046958 GC01P046221 GC01P046651 GC01P046634 GC01P046976 GC01P047037 GC01P047264 GC01P045380


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4B1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has
been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been
determined. Two transcript variants encoding slightly different isoforms have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CYP4B1 Gene:
CYP4B1 (cytochrome P450, family 4, subfamily B, polypeptide 1) is a protein-coding gene. Diseases associated with CYP4B1 include herpes simplex, and nasopharyngitis. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP4B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4B1 gene promoter:
         Max1   FOXD1   AP-4   Nkx5-1   Arnt   AREB6   POU2F1   POU2F1a   Zic3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4B1 promoter sequence
   Search Chromatin IP Primers for CYP4B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4B1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047227:  view genomic region     (about GC identifiers)

Start:
47,223,510 bp from pter      End:
47,285,085 bp from pter
Size:
61,576 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584 (See protein sequence)
Recommended Name: Cytochrome P450 4B1  
Size: 511 amino acids; 58991 Da
Cofactor: Heme group (By similarity)
Secondary accessions: Q1HBI2 Q8TD85 Q8WWF2 Q8WWU9 Q8WWV0
Alternative splicing: 2 isoforms:  P13584-1   P13584-2   

Explore the universe of human proteins at neXtProt for CYP4B1: NX_P13584

Explore proteomics data for CYP4B1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CYP4B1 (P13584)
     TLMKCTFG  VWPDPEVFD  GPRNCIGQQFAM  QHRKLLTPGFHYDVLKPYVA 


    See CYP4B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000770.2  NP_001093242.1  

    ENSEMBL proteins: 
     ENSP00000433367   ENSP00000360991   ENSP00000271153   ENSP00000443212   ENSP00000433068  
     ENSP00000360987   ENSP00000438995   ENSP00000400413   ENSP00000437670  
    Reactome Protein details: P13584

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4B1
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P13584

    ProtoNet protein and cluster: P13584

    UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
    Similarity: Belongs to the cytochrome P450 family


    CYP4B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4B1_HUMAN, P13584
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including
    drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP4B1:
    cytochrome P450,subfamily IVB1,expressed in lung

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0008144drug binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0018585fluorene oxygenase activity IEA--
         
    CYP4B1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cyp4b1 (no phenotypes)

    CYP4B1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4B1
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    Sino Biological Human cDNA Clone for CYP4B1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4B1_HUMAN, P13584: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    golgi apparatus2
    peroxisome2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle ----

    CYP4B1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4B1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Miscellaneous substrates0.00
    cytochrome P4500.74
    Eicosanoids0.00
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Nuclear receptors in lipid metabolism and toxicity
    Nuclear receptors in lipid metabolism and toxicity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for CYP4B1
        cytochrome P450
    Nuclear receptors in lipid metabolism and toxicity
    metapathway biotransformation


    4 Reactome Pathways for CYP4B1
        Miscellaneous substrates
    Fatty acids
    Eicosanoids
    Synthesis of Leukotrienes (LT) and Eoxins (EX)



    CYP4B1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP4B1: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CYP4B1 (P135843 ENSP000003609914) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DFFAO002733, ENSP000003662374I2D: score=1 STRING: ENSP00000366237
    LSSENSP000003487624STRING: ENSP00000348762
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    SQLEENSP000002658964STRING: ENSP00000265896
    DIDO1ENSP000002660704STRING: ENSP00000266070
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006725cellular aromatic compound metabolic process ----
    GO:0006805xenobiotic metabolic process TAS--
    GO:0018879biphenyl metabolic process IEA--
    GO:0018917fluorene metabolic process IEA--
    GO:0042738exogenous drug catabolic process IEA--

    CYP4B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4B1 (CP4B1)

    Selected HMDB Compounds for CYP4B1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    3 DrugBank Compounds for CYP4B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MidazolamDea No. 2884 (see all 4)59467-70-8enzymesubstrate11996015
    PhenobarbitalFenobarbital (see all 7)50-06-6enzymeinducer19934256
    ThiamineThiadoxine (see all 5)59-43-8enzymeinducer15328374

    5 Novoseek inferred chemical compound relationships for CYP4B1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-ipomeanol 91.7 9 9650611 (2), 10830728 (1), 10917203 (1), 12639503 (1)
    2-aminofluorene 84.7 8 11062028 (1), 7894498 (1), 18713828 (1), 11396967 (1) (see all 5)
    3-methylindole 76.9 1 20187624 (1)
    2-aminoanthracene 73 4 9650611 (2), 10917203 (1)
    lauric acid 63.6 2 11396967 (1), 12639503 (1)

    2 PharmGKB related drug/compound annotations for CYP4B1 gene    About this table
    Drug/compound PharmGKB Annotation
    docetaxelCA  
    thalidomideCA  



    CYP4B1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP4B1 gene (2 alternative transcripts): 
    NM_000779.3  NM_001099772.1  

    Unigene Cluster for CYP4B1:

    Cytochrome P450, family 4, subfamily B, polypeptide 1
    Hs.436317  [show with all ESTs]
    Unigene Representative Sequence: NM_001099772
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546128 ENST00000413093 ENST00000534708 ENST00000371923(uc001cqn.4 uc001cqm.4 uc009vym.3 uc010omk.2)
    ENST00000271153 ENST00000529715(uc009vyl.1) ENST00000464439 ENST00000371919
    ENST00000526297 ENST00000452782(uc010oml.1) ENST00000468637 ENST00000481248
    ENST00000497005
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      QuantiFast Probe-based Assays in human, mouse, rat CYP4B1

    Additional mRNA sequence: 

    AF491285.1 AK225576.1 AK225578.1 AK300921.1 AK300941.1 AK307715.1 AK313170.1 AY064484.1 
    AY064485.1 AY064486.1 AY151048.1 AY151049.1 BC017758.1 J02871.1 X16699.1 

    7 DOTS entries:

    DT.111100  DT.101980207  DT.100776898  DT.97826031  DT.97837690  DT.121455988  DT.97762269 

    Selected AceView cDNA sequences (see all 96):

    AY151049 BC017758 BM980704 BM976673 BM980737 BQ045121 AA036869 BM975516 
    BQ881161 CD519012 BM977596 AY064486 BM982410 BU684574 BM977024 CD013981 
    CD171911 CB306078 BQ029538 AY151048 AF491285 BQ029986 BF001158 AY064485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP4B1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                          -           -                                                                                 
    SP2:                          -           -                       -                                                         
    SP3:                          -           -                                                                                 
    SP4:                          -     -     -                                                                                 
    SP5:                          -     -                                                                                       


    ECgene alternative splicing isoforms for CYP4B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP4B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATGGCTG
    CYP4B1 Expression
    About this image


    CYP4B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    CYP4B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436317

    UniProtKB/Swiss-Prot: CP4B1_HUMAN, P13584
    Tissue specificity: Detected in the liver and lung (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP4B1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4b11 , 5 cytochrome P450, family 4, subfamily b, polypeptide more1, 5 86.14(n)1
    85.74(a)1
      4 (53.06 cM)5
    131201  NM_007823.21  NP_031849.11 
     1156247255 
    chicken
    (Gallus gallus)
    Aves LOC7719741 cytochrome P450 4B1-like 65.17(n)
    59.71(a)
      771974  XM_001235179.3  XP_001235180.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    54(a)
    53(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343249.1(1880734-1908444)
    GL343249.1(1942574-1982744)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004879181 cytochrome P450 4B1-like 60.61(n)
    57.14(a)
      100487918  XM_002931446.2  XP_002931492.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp4t81 cytochrome P450, family 4, subfamily T, polypeptide more 57.89(n)
    51.73(a)
      387527  NM_199216.1  NP_954686.1 


    ENSEMBL Gene Tree for CYP4B1 (if available)
    TreeFam Gene Tree for CYP4B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4B1 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    17 SIMAP similar genes for CYP4B1 using alignment to 9 protein entries:     CP4B1_HUMAN (see all proteins):
    CYP4X1    CYP4Z1    CYP4A11    CYP4F8    CYP4F22    CYP4Z2P
    CYP4F3    CYP4F12    CYP4F2    CYP4F11    DKFZp761K058    CYP4A22
    CYP3A5    CYP3A4    CYP3A43    CYP46A1    CYP4V2

    CYP4B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4B1 (see all 694)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101577521,2
    C--45381540(+) ccttcC/Tttcct 2 -- int1 trp30--------
    rs670499021,2
    C--47265846(+) TTTCT-/TCTT  
      TCTTTC
    TCTTT
    2 -- int10--------
    rs601037361,2
    C--47265881(+) TTTCTC/TTCTTT 2 -- int11Minor allele frequency- T:0.00NA 2
    rs671037111,2
    C--47265917(+) CCTTC-/CC/TT 
            
    CTTCC
    2 -- int10--------
    rs455984351,2
    C,F--47269654(+) GTCAT-/TGCAGA 2 -- int15Minor allele frequency- T:0.02NS 188
    rs124037201,2
    C,H--47274557(+) aacacC/Tgcata 2 -- int10--------
    rs46464891,2
    C,F--47279559(+) CAATCCCT/-CCTCC 2 -- int1 trp35Minor allele frequency- -:0.13NS 180
    rs1432528001,2
    --47340209(+) ACAGGA/CGCACC 2 -- us2k10--------
    rs1483243991,2
    --47340233(+) CAAGTA/CCTTAG 2 -- us2k10--------
    rs45609831,2
    C--47340274(+) aataaT/Caatgg 2 -- us2k12Minor allele frequency- C:0.00NA 4

    HapMap Linkage Disequilibrium report for CYP4B1 (47223510 - 47285085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP4B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870538CNV Gain21882294
    nsv870792CNV Gain21882294

    The Human Cytochrome P450 Allele Nomenclature Database: CYP4B1 
    Human Gene Mutation Database (HGMD): CYP4B1
    Locus Specific Mutation Databases (LSDB): CYP4B1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124075    OMIM disorders: --

    10 diseases for CYP4B1:    
    About MalaCards
    herpes simplex    nasopharyngitis    chronic lymphocytic leukemia    tuberculosis
    hepatocellular carcinoma    prostatitis    prostate cancer    retinitis
    leukemia    hepatitis


    CYP4B1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CYP4B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder tumors 36.6 2 11062028 (2)
    bladder cancer 31.4 6 18713828 (5), 11062028 (1)
    glioma 13 1 9650611 (1)
    cancer lung 0 1 8313365 (1)
    tumors 0 7 9650611 (2), 11062028 (1), 10917203 (1), 11059566 (1)
    cancer 0 1 9650611 (1)

    Genetic Association Database (GAD): CYP4B1
    Human Genome Epidemiology (HuGE) Navigator: CYP4B1 (11 documents)

    Export disorders for CYP4B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4B1 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with CYP4B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. (PubMed id 12142726)1, 2, 4, 9 Lo-Guidice J.-M.... Broly F. (Pharmacogenetics 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    7. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    8. Human CYP4B1 gene in the japanese population analyzed by denaturing HPLC. (PubMed id 15499177)1, 4 Hiratsuka M....Mizugaki M. (Drug Metab. Pharmacokinet. 2004)
    9. cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression. (PubMed id 2298205)1, 2 Yokotani N.... Fujii-Kuriyama Y. (Eur. J. Biochem. 1990)
    10. Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. (PubMed id 2574990)1, 2 Nhamburo P.T.... Kimura S. (Biochemistry 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1580 HGNC: 2644 AceView: CYP4B1 Ensembl:ENSG00000142973 euGenes: HUgn1580
    ECgene: CYP4B1 H-InvDB: CYP4B1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP4B1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP4B1 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp4b1.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp4b1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4B1 gene:
    Search GeneIP for patents involving CYP4B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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