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Aliases for CYP4B1 Gene

Aliases for CYP4B1 Gene

  • Cytochrome P450 Family 4 Subfamily B Member 1 2 3 5
  • Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily IVB, Polypeptide 1 2 3
  • Cytochrome P450-HP 3 4
  • EC 1.14.14.1 4 61
  • CYPIVB1 3 4
  • Microsomal Monooxygenase 3
  • Cytochrome P450 4B1 3
  • P-450HP 3

External Ids for CYP4B1 Gene

Previous GeneCards Identifiers for CYP4B1 Gene

  • GC01P046958
  • GC01P046221
  • GC01P046651
  • GC01P046634
  • GC01P046976
  • GC01P047037
  • GC01P047264
  • GC01P045380
  • GC01P047227

Summaries for CYP4B1 Gene

Entrez Gene Summary for CYP4B1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP4B1 Gene

CYP4B1 (Cytochrome P450 Family 4 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP4B1 include Bladder Cancer, Somatic. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4A11.

UniProtKB/Swiss-Prot for CYP4B1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP4B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4B1 Gene

Genomics for CYP4B1 Gene

Regulatory Elements for CYP4B1 Gene

Enhancers for CYP4B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F046804 1 Ensembl ENCODE 23.2 +48.3 48311 4.2 PKNOX1 HLF CEBPB MAX PRDM10 NR3C1 REST NR2F2 CYP4B1 CYP4A11 CYP4X1 GC01M046749 LOC100533627
GH01F046939 0.5 ENCODE 15 +183.5 183522 2.9 GATAD2A ZNF263 CTCF NFIA HLF FOXA3 CEBPB CEBPG REST RAD21 CYP4A11 CYP4B1 PIR40895
GH01F046954 0.4 ENCODE 14.1 +197.1 197148 1.7 ZNF263 ZBTB40 CYP4A11 CYP4B1 CYP4X1
GH01F046749 0.5 ENCODE 11 -8.0 -7999 1.6 HDGF YBX3 PKNOX1 SAP130 ZNF384 YBX1 FOSL1 ZNF316 GATA3 POLR2A EFCAB14 CYP4B1 EFCAB14-AS1 CYP4X1 MKNK1 GC01P046743
GH01F046717 0.4 ENCODE 10.8 -39.1 -39054 3.3 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 EFCAB14 EFCAB14-AS1 NSUN4 TEX38 CYP4B1 NENFP1 ATPAF1 PIR52630 LOC105378698
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CYP4B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4B1 Gene

Chromosome:
1
Start:
46,757,838 bp from pter
End:
46,819,413 bp from pter
Size:
61,576 bases
Orientation:
Plus strand

Genomic View for CYP4B1 Gene

Genes around CYP4B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4B1 Gene

Proteins for CYP4B1 Gene

  • Protein details for CYP4B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13584-CP4B1_HUMAN
    Recommended name:
    Cytochrome P450 4B1
    Protein Accession:
    P13584
    Secondary Accessions:
    • Q1HBI2
    • Q8TD85
    • Q8WWF2
    • Q8WWU9
    • Q8WWV0

    Protein attributes for CYP4B1 Gene

    Size:
    511 amino acids
    Molecular mass:
    58991 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4B1 Gene

Selected DME Specific Peptides for CYP4B1 Gene

Post-translational modifications for CYP4B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CYP4B1 Gene

Gene Families for CYP4B1 Gene

Protein Domains for CYP4B1 Gene

Suggested Antigen Peptide Sequences for CYP4B1 Gene

Graphical View of Domain Structure for InterPro Entry

P13584

UniProtKB/Swiss-Prot:

CP4B1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4B1: view

Function for CYP4B1 Gene

Molecular function for CYP4B1 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IVB1,expressed in lung
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP4B1 Gene

Gene Ontology (GO) - Molecular Function for CYP4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008144 drug binding IEA --
GO:0015643 toxic substance binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP4B1: view
genes like me logo Genes that share phenotypes with CYP4B1: view

Animal Models for CYP4B1 Gene

MGI Knock Outs for CYP4B1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4B1 Gene

Localization for CYP4B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4B1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4B1 Gene COMPARTMENTS Subcellular localization image for CYP4B1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4B1: view

Pathways & Interactions for CYP4B1 Gene

genes like me logo Genes that share pathways with CYP4B1: view

Gene Ontology (GO) - Biological Process for CYP4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006725 cellular aromatic compound metabolic process IEA --
GO:0018879 biphenyl metabolic process IEA --
GO:0018917 fluorene metabolic process IEA --
GO:0042738 exogenous drug catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4B1: view

No data available for SIGNOR curated interactions for CYP4B1 Gene

Drugs & Compounds for CYP4B1 Gene

(24) Drugs for CYP4B1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Midazolam Approved, Illicit Pharma Enzyme, substrate 684
Phenobarbital Approved Pharma Agonist, Enzyme, inducer 55
Thiamine Approved, Vet_approved Nutra Enzyme, inducer 98,98
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1105

(27) Additional Compounds for CYP4B1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP4B1: view

Transcripts for CYP4B1 Gene

Unigene Clusters for CYP4B1 Gene

Cytochrome P450, family 4, subfamily B, polypeptide 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4B1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for CYP4B1 Gene

GeneLoc Exon Structure for
CYP4B1
ECgene alternative splicing isoforms for
CYP4B1

Expression for CYP4B1 Gene

mRNA expression in normal human tissues for CYP4B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4B1 Gene

This gene is overexpressed in Nerve - Tibial (x6.8), Lung (x5.2), Bladder (x4.8), Adipose - Visceral (Omentum) (x4.3), and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for CYP4B1 Gene

This gene is overexpressed in Nasal epithelium (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4B1 Gene



Protein tissue co-expression partners for CYP4B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP4B1 Gene:

CYP4B1

SOURCE GeneReport for Unigene cluster for CYP4B1 Gene:

Hs.436317

mRNA Expression by UniProt/SwissProt for CYP4B1 Gene:

P13584-CP4B1_HUMAN
Tissue specificity: Detected in the liver and lung (at protein level).
genes like me logo Genes that share expression patterns with CYP4B1: view

Primer Products

Orthologs for CYP4B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC456557 34
  • 99.4 (n)
CYP4B1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP4B1 34 35
  • 87.28 (n)
rat
(Rattus norvegicus)
Mammalia Cyp4b1 34
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Cyp4b1 34 16 35
  • 86.14 (n)
cow
(Bos Taurus)
Mammalia CYP4B1 34 35
  • 84.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CYP4B1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYP4B1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC771974 34
  • 65.17 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487918 34
  • 60.61 (n)
zebrafish
(Danio rerio)
Actinopterygii cyp4t8 34
  • 57.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cyp4d2 36
  • 37 (a)
Cyp4d14 36
  • 35 (a)
Cyp4d8 36
  • 35 (a)
Cyp4g15 36
  • 35 (a)
Cyp4ae1 36
  • 34 (a)
Cyp4s3 36
  • 34 (a)
Cyp4c3 36
  • 33 (a)
Cyp4d1 36
  • 33 (a)
Cyp4d20 36
  • 32 (a)
Cyp311a1 36
  • 30 (a)
Cyp4ac1 36
  • 30 (a)
Cyp4e2 36
  • 30 (a)
Cyp4p1 36
  • 30 (a)
Cyp4p2 36
  • 30 (a)
Cyp4e1 36
  • 29 (a)
Cyp4g1 36
  • 29 (a)
Cyp4p3 36
  • 29 (a)
Cyp312a1 36
  • 28 (a)
Cyp4ac2 36
  • 28 (a)
Cyp4e3 36
  • 28 (a)
Cyp4aa1 36
  • 27 (a)
Cyp4ad1 36
  • 27 (a)
Cyp313a1 36
  • 26 (a)
Cyp313b1 36
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F01D5.9 36
  • 36 (a)
Y38C9B.1 36
  • 34 (a)
F28G4.1 36
  • 32 (a)
Y17G9B.3 36
  • 32 (a)
Y5H2B.5 36
  • 32 (a)
Y80D3A.5 36
  • 32 (a)
B0331.1 36
  • 31 (a)
C26F1.2 36
  • 29 (a)
Species where no ortholog for CYP4B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP4B1 Gene

ENSEMBL:
Gene Tree for CYP4B1 (if available)
TreeFam:
Gene Tree for CYP4B1 (if available)

Paralogs for CYP4B1 Gene

Variants for CYP4B1 Gene

Sequence variations from dbSNP and Humsavar for CYP4B1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157752 -- 46,800,258(+) ccttc(C/T)ttcct intron-variant
rs10157754 -- 46,800,294(+) CCTTC(C/T)TTCCT intron-variant
rs10157755 -- 46,800,327(+) TCTCT(C/T)TCTTT intron-variant
rs10158419 -- 46,800,219(+) tctct(C/T)tctct intron-variant
rs10629635 -- 46,816,581(+) AAAAG(-/AC/ACACACACAC)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4B1 Gene

Variant ID Type Subtype PubMed ID
dgv160n100 CNV gain 25217958
esv3585938 CNV gain 21293372
esv3585939 CNV gain 21293372
esv3585940 CNV loss 21293372
nsv1010063 CNV gain 25217958
nsv1011086 CNV gain 25217958
nsv546165 CNV loss 21841781

Variation tolerance for CYP4B1 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.42; 99.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4B1 Gene

Human Gene Mutation Database (HGMD)
CYP4B1
The Human Cytochrome P450 Allele Nomenclature Database
CYP4B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4B1 Gene

Disorders for CYP4B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CYP4B1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
bladder cancer, somatic
  • bladder carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP4B1

Genetic Association Database (GAD)
CYP4B1
Human Genome Epidemiology (HuGE) Navigator
CYP4B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4B1
genes like me logo Genes that share disorders with CYP4B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4B1 Gene

Publications for CYP4B1 Gene

  1. Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. (PMID: 12142726) Lo-Guidice J.-M. … Broly F. (Pharmacogenetics 2002) 3 4 22 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 46 64

Products for CYP4B1 Gene

Sources for CYP4B1 Gene

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