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Aliases for CYP4A22 Gene

Aliases for CYP4A22 Gene

  • Cytochrome P450 Family 4 Subfamily A Member 22 2 3 5
  • Cytochrome P450, Family 4, Subfamily A, Polypeptide 22 2 3
  • Long-Chain Fatty Acid Omega-Monooxygenase 3 4
  • Lauric Acid Omega-Hydroxylase 3 4
  • Fatty Acid Omega-Hydroxylase 3 4
  • CYPIVA22 3 4
  • Cytochrome P450 4A22K 3
  • EC 1.14.13.205 4

External Ids for CYP4A22 Gene

Previous GeneCards Identifiers for CYP4A22 Gene

  • GC00U916975
  • GC01P047314
  • GC01P047376
  • GC01P047603
  • GC01P045719

Summaries for CYP4A22 Gene

Entrez Gene Summary for CYP4A22 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for CYP4A22 Gene

CYP4A22 (Cytochrome P450 Family 4 Subfamily A Member 22) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP4A22 Gene

  • Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.

Gene Wiki entry for CYP4A22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4A22 Gene

Genomics for CYP4A22 Gene

Regulatory Elements for CYP4A22 Gene

Genomic Location for CYP4A22 Gene

Chromosome:
1
Start:
47,137,435 bp from pter
End:
47,149,741 bp from pter
Size:
12,307 bases
Orientation:
Plus strand

Genomic View for CYP4A22 Gene

Genes around CYP4A22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4A22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4A22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4A22 Gene

Proteins for CYP4A22 Gene

  • Protein details for CYP4A22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCH4-CP4AM_HUMAN
    Recommended name:
    Cytochrome P450 4A22
    Protein Accession:
    Q5TCH4
    Secondary Accessions:
    • Q5TCH3
    • Q6JXK7
    • Q6JXK8
    • Q9NRM4

    Protein attributes for CYP4A22 Gene

    Size:
    519 amino acids
    Molecular mass:
    59246 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4A22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4A22 Gene

Proteomics data for CYP4A22 Gene at MOPED

Post-translational modifications for CYP4A22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4A22 Gene

No data available for DME Specific Peptides for CYP4A22 Gene

Domains & Families for CYP4A22 Gene

Gene Families for CYP4A22 Gene

Protein Domains for CYP4A22 Gene

Suggested Antigen Peptide Sequences for CYP4A22 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TCH4

UniProtKB/Swiss-Prot:

CP4AM_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4A22: view

Function for CYP4A22 Gene

Molecular function for CYP4A22 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=56.7 uM for laurate {ECO:0000269 PubMed:10860550}; Note=Vmax:15.2 umol/min/umol enzyme.;
UniProtKB/Swiss-Prot CatalyticActivity:
A long-chain fatty acid + NADPH + O(2) = an omega-hydroxy-long-chain fatty acid + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.

Enzyme Numbers (IUBMB) for CYP4A22 Gene

Gene Ontology (GO) - Molecular Function for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP4A22: view
genes like me logo Genes that share phenotypes with CYP4A22: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4A22 Gene

Localization for CYP4A22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4A22 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4A22 Gene COMPARTMENTS Subcellular localization image for CYP4A22 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
peroxisome 2
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4A22 Gene

Pathways & Interactions for CYP4A22 Gene

genes like me logo Genes that share pathways with CYP4A22: view

Pathways by source for CYP4A22 Gene

Interacting Proteins for CYP4A22 Gene

Gene Ontology (GO) - Biological Process for CYP4A22 Gene

None

No data available for SIGNOR curated interactions for CYP4A22 Gene

Drugs & Compounds for CYP4A22 Gene

(8) Drugs for CYP4A22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist 210
Glycolic acid Experimental Pharma 12
Octane Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 27
heme Pharma Agonist 0

(8) Additional Compounds for CYP4A22 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12-EpETrE
  • (+/-)11(12)-EET
  • (+/-)11(12)-EpETrE
  • (+/-)11,12-EpETrE
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
all-trans-18-Hydroxyretinoic acid
  • 18-Hydroxy-all-trans-retinoate
  • 18-Hydroxy-all-trans-retinoic acid
  • Rac-18-hydroxy-all-trans-retinoate
  • Rac-18-hydroxy-all-trans-retinoic acid
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with CYP4A22: view

Transcripts for CYP4A22 Gene

mRNA/cDNA for CYP4A22 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4A22 Gene

No ASD Table

Relevant External Links for CYP4A22 Gene

GeneLoc Exon Structure for
CYP4A22
ECgene alternative splicing isoforms for
CYP4A22

Expression for CYP4A22 Gene

mRNA expression in normal human tissues for CYP4A22 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4A22 Gene

This gene is overexpressed in Liver (x43.8) and Kidney - Cortex (x7.1).

Protein differential expression in normal tissues from HIPED for CYP4A22 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4A22 Gene



genes like me logo Genes that share expression patterns with CYP4A22: view

Protein tissue co-expression partners for CYP4A22 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CYP4A22 Gene

Orthologs for CYP4A22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4A22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP4A22 35
  • 80.79 (n)
  • 76.95 (a)
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
CYP4A22 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CYP4A38 35
  • 82.65 (n)
  • 76.82 (a)
-- 36
  • 73 (a)
ManyToMany
CYP4A37 36
  • 77 (a)
ManyToMany
CYP4A38 36
  • 76 (a)
ManyToMany
CYP4A39 36
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4a12b 35
  • 79.62 (n)
  • 75.54 (a)
Cyp4a12b 16
Cyp4a12a 36
  • 75 (a)
ManyToMany
Cyp4a14 36
  • 70 (a)
ManyToMany
Cyp4a31 36
  • 73 (a)
ManyToMany
Cyp4a32 36
  • 74 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC456835 35
  • 99.23 (n)
  • 98.07 (a)
CYP4A22 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4a8 35
  • 79.82 (n)
  • 74.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP4B1 35
  • 61.93 (n)
  • 55.2 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP715A1 35
  • 44.14 (n)
  • 32.43 (a)
rice
(Oryza sativa)
Liliopsida Os02g0824100 35
  • 43.96 (n)
  • 28.06 (a)
Species with no ortholog for CYP4A22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4A22 Gene

ENSEMBL:
Gene Tree for CYP4A22 (if available)
TreeFam:
Gene Tree for CYP4A22 (if available)

Paralogs for CYP4A22 Gene

genes like me logo Genes that share paralogs with CYP4A22: view

Variants for CYP4A22 Gene

Sequence variations from dbSNP and Humsavar for CYP4A22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs76011927 - 47,137,516(+) GCAGA(C/T)GCCTG reference, missense
rs2758717 - 47,141,595(-) GGAAT(C/T)TGTAG reference, missense
rs12564525 - 47,141,609(+) CTCCA(C/T)GGATT reference, missense
rs2056900 - 47,142,113(-) CAAGC(A/C/T)GTACC reference, missense
rs2056899 - 47,142,179(-) GTCAT(A/T)GTGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP4A22 Gene

Variant ID Type Subtype PubMed ID
dgv221n71 CNV Gain 21882294

Variation tolerance for CYP4A22 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.98; 99.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4A22 Gene

HapMap Linkage Disequilibrium report
CYP4A22
Human Gene Mutation Database (HGMD)
CYP4A22
The Human Cytochrome P450 Allele Nomenclature Database
CYP4A22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4A22 Gene

Disorders for CYP4A22 Gene

Relevant External Links for CYP4A22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4A22

No disorders were found for CYP4A22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4A22 Gene

Publications for CYP4A22 Gene

  1. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PMID: 15611369) Gainer J.V. … Capdevila J.H. (Circulation 2005) 3 4 67
  2. Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site. (PMID: 20079672) Gajendrarao P. … Lee K.W. (J. Mol. Graph. Model. 2010) 3 23
  3. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3
  4. Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. (PMID: 21820496) Lino Cardenas C.L. … Chevalier D. (Gene 2011) 3
  5. Altered fatty acid homeostasis and related toxicologic sequelae in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS). (PMID: 18923995) Curran I. … Bondy G. (J. Toxicol. Environ. Health Part A 2008) 23

Products for CYP4A22 Gene

Sources for CYP4A22 Gene

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