Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYP4A22 Gene

Aliases for CYP4A22 Gene

  • Cytochrome P450, Family 4, Subfamily A, Polypeptide 22 2 3
  • Lauric Acid Omega-Hydroxylase 3 4
  • Fatty Acid Omega-Hydroxylase 3 4
  • CYPIVA22 3 4
  • Cytochrome P450 4A22K 3
  • Cytochrome P450 4A22 3
  • EC 1.14.15.3 4

External Ids for CYP4A22 Gene

Previous GeneCards Identifiers for CYP4A22 Gene

  • GC00U916975
  • GC01P047314
  • GC01P047376
  • GC01P047603
  • GC01P045719

Summaries for CYP4A22 Gene

Entrez Gene Summary for CYP4A22 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4A22 Gene

CYP4A22 (Cytochrome P450, Family 4, Subfamily A, Polypeptide 22) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP4A22 Gene

  • Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.

Gene Wiki entry for CYP4A22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4A22 Gene

Genomics for CYP4A22 Gene

Regulatory Elements for CYP4A22 Gene

Genomic Location for CYP4A22 Gene

Start:
47,137,435 bp from pter
End:
47,149,741 bp from pter
Size:
12,307 bases
Orientation:
Plus strand

Genomic View for CYP4A22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4A22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4A22 Gene

Proteins for CYP4A22 Gene

  • Protein details for CYP4A22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCH4-CP4AM_HUMAN
    Recommended name:
    Cytochrome P450 4A22
    Protein Accession:
    Q5TCH4
    Secondary Accessions:
    • Q5TCH3
    • Q6JXK7
    • Q6JXK8
    • Q9NRM4

    Protein attributes for CYP4A22 Gene

    Size:
    519 amino acids
    Molecular mass:
    59246 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4A22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4A22 Gene

Proteomics data for CYP4A22 Gene at MOPED

Post-translational modifications for CYP4A22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4A22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4A22 Gene

Domains for CYP4A22 Gene

Gene Families for CYP4A22 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP4A22 Gene

Suggested Antigen Peptide Sequences for CYP4A22 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TCH4

UniProtKB/Swiss-Prot:

CP4AM_HUMAN :
  • Q5TCH4
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4A22: view

Function for CYP4A22 Gene

Molecular function for CYP4A22 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=56.7 uM for laurate {ECO:0000269 PubMed:10860550}; Note=Vmax:15.2 umol/min/umol enzyme.;
UniProtKB/Swiss-Prot CatalyticActivity: Octane + 2 reduced rubredoxin + O(2) + 2 H(+) = 1-octanol + 2 oxidized rubredoxin + H(2)O.
UniProtKB/Swiss-Prot Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.

Enzyme Numbers (IUBMB) for CYP4A22 Gene

Gene Ontology (GO) - Molecular Function for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0018685 alkane 1-monooxygenase activity IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP4A22: view

miRNA for CYP4A22 Gene

miRTarBase miRNAs that target CYP4A22

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP4A22 Gene

Localization for CYP4A22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4A22 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4A22 Gene COMPARTMENTS Subcellular localization image for CYP4A22 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
peroxisome 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CYP4A22: view

Pathways for CYP4A22 Gene

genes like me logo Genes that share pathways with CYP4A22: view

Pathways by source for CYP4A22 Gene

Interacting Proteins for CYP4A22 Gene

Gene Ontology (GO) - Biological Process for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4A22: view

Compounds for CYP4A22 Gene

(11) HMDB Compounds for CYP4A22 Gene

Compound Synonyms Cas Number PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
79551-86-3
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Heme
  • (protoporphyrinato)iron
14875-96-8
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
genes like me logo Genes that share compounds with CYP4A22: view

Transcripts for CYP4A22 Gene

mRNA/cDNA for CYP4A22 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4A22 Gene

No ASD Table

Relevant External Links for CYP4A22 Gene

GeneLoc Exon Structure for
CYP4A22
ECgene alternative splicing isoforms for
CYP4A22

Expression for CYP4A22 Gene

mRNA expression in normal human tissues for CYP4A22 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4A22 Gene

This gene is overexpressed in Liver (43.8) and Kidney - Cortex (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP4A22 Gene

genes like me logo Genes that share expressions with CYP4A22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CYP4A22 Gene

Orthologs for CYP4A22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4A22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4A22 36
  • 98 (a)
OneToOne
LOC456835 35
  • 99.23 (n)
  • 98.07 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
CYP4A22 35
  • 80.79 (n)
  • 76.95 (a)
CYP4A22 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
ManyToMany
CYP4A37 36
  • 77 (a)
ManyToMany
CYP4A38 35
  • 82.65 (n)
  • 76.82 (a)
CYP4A38 36
  • 76 (a)
ManyToMany
CYP4A39 36
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4a12a 36
  • 75 (a)
ManyToMany
Cyp4a12b 35
  • 79.62 (n)
  • 75.54 (a)
Cyp4a12b 16
Cyp4a14 36
  • 70 (a)
ManyToMany
Cyp4a31 36
  • 73 (a)
ManyToMany
Cyp4a32 36
  • 74 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp4a8 35
  • 79.82 (n)
  • 74.56 (a)
chicken
(Gallus gallus)
Aves CYP4B1 35
  • 61.93 (n)
  • 55.2 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP715A1 35
  • 44.14 (n)
  • 32.43 (a)
rice
(Oryza sativa)
Liliopsida Os02g0824100 35
  • 43.96 (n)
  • 28.06 (a)
Species with no ortholog for CYP4A22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4A22 Gene

ENSEMBL:
Gene Tree for CYP4A22 (if available)
TreeFam:
Gene Tree for CYP4A22 (if available)

Paralogs for CYP4A22 Gene

Selected SIMAP similar genes for CYP4A22 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CYP4A22: view

Variants for CYP4A22 Gene

Sequence variations from dbSNP and Humsavar for CYP4A22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs741957 -- 47,145,492(+) CTCAG(A/G)TATCT intron-variant
rs760440 -- 47,148,513(-) CTGAG(C/G)TGGAC intron-variant
rs760441 -- 47,147,390(-) ACTTT(A/T)ATATT intron-variant, utr-variant-3-prime
rs760442 -- 47,147,169(-) TGTTC(C/T)ATGTA intron-variant, utr-variant-3-prime
rs911903 -- 47,147,000(-) CTCAA(C/T)AGCTA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYP4A22 Gene

Variant ID Type Subtype PubMed ID
dgv221n71 CNV Gain 21882294

Relevant External Links for CYP4A22 Gene

HapMap Linkage Disequilibrium report
CYP4A22
Human Gene Mutation Database (HGMD)
CYP4A22
Locus Specific Mutation Databases (LSDB)
CYP4A22
The Human Cytochrome P450 Allele Nomenclature Database
CYP4A22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4A22 Gene

Disorders for CYP4A22 Gene

No disorders were found for CYP4A22 Gene.

No data available for UniProtKB/Swiss-Prot for CYP4A22 Gene

Publications for CYP4A22 Gene

  1. Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site. (PMID: 20079672) Gajendrarao P. … Lee K.W. (J. Mol. Graph. Model. 2010) 3 23
  2. Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. (PMID: 10860550) Kawashima H. … Kishimoto T. (Arch. Biochem. Biophys. 2000) 3 4
  3. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PMID: 15611369) Gainer J.V. … Capdevila J.H. (Circulation 2005) 3 4
  4. Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. (PMID: 21820496) Lino Cardenas C.L. … Chevalier D. (Gene 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for CYP4A22 Gene

  • antibodies-online peptides for CYP4A22
  • antibodies-online antibodies for CYP4A22
  • antibodies-online kits for CYP4A22

Sources for CYP4A22 Gene

Back to Top

Content