CYP4A22 Gene
protein-coding GIFtS: 45
GCID: GC01P047603
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cytochrome P450, family 4, subfamily A, polypeptide 22
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Aliases
for CYP4A22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 4, Subfamily A, Polypeptide 221 2 | | Cytochrome P450 4A222 | | Fatty Acid Omega-Hydroxylase2 3 | | Cytochrome P450 4A22K2 | | Lauric Acid Omega-Hydroxylase2 3 | | EC 1.14.15.33 | | CYPIVA222 3 | | |
Export aliases for CYP4A22 gene to outside databasesPrevious GC identifers: GC00U916975 GC01P047314 GC01P047376 GC01P045719 |
Summaries
for CYP4A22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP4A22:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Showsno activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does notcontribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis
Gene Wiki entry for CYP4A22
|
Genomic Views
for CYP4A22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP4A22 gene promoter:
GR AML1a HTF LCR-F1 SEF-1 (1) GR-alpha MRF-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP4A22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4A22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33CYP4A22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P047603: view genomic region
(about GC identifiers)
Start:
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47,603,107 bp from pter |
End:
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47,615,413 bp from pter |
Size:
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12,307 bases |
Orientation:
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plus strand |
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Proteins
for CYP4A22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4 (See
protein sequence)Recommended Name: Cytochrome P450 4A22 precursor Size: 519 amino acids; 59246 Da
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane;Peripheral membrane protein (By similarity)
Caution: Was originally (PubMed:10860550) termed CYP4A11
Secondary accessions: Q5TCH3 Q6JXK7 Q6JXK8 Q9NRM4Alternative splicing: 2 isoforms: Q5TCH4-1 Q5TCH4-2 Explore the universe of human proteins at neXtProt for CYP4A22: NX_Q5TCH4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TCH4
CYP4A22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010969.2
ENSEMBL proteins: ENSP00000360957 ENSP00000294337 ENSP00000360958
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0005792 | microsome |
-- | -- |
CYP4A22 for ontologies About GeneDecksing
CYP4A22 Antibody Products:
Assay Products for CYP4A22: |
Protein
Domains /
Families
for CYP4A22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP4A22 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TCH4ProtoNet protein and cluster: Q5TCH4 UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4Similarity: Belongs to the cytochrome P450 family |
Function
for CYP4A22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Showsno activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does notcontribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesisCatalytic activity: Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)OBiophysicochemical properties: Kinetic parameters: KM=56.7 uM for laurate; Note=Vmax:15.2 umol/min/umol enzyme;Enzyme Number (IUBMB): EC 1.14.15.31
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4A22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4A22 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP4A22 (NM_001010969) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4A22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4A22 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4A22 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004497 | monooxygenase activity |
-- | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
-- | -- | | GO:0018685 | alkane 1-monooxygenase activity |
IEA | -- |
CYP4A22 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYP4A22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PPAR signaling pathway | | | 2 | Cytochrome P450 - arranged by substrate type | | | 3 | Arachidonic acid metabolism | | | 4 | Drug metabolism - cytochrome P450 | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CYP4A22
5/6 
Kegg Pathways (Kegg details for CYP4A22) (see all 6):
CYP4A22 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4A22
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/73 Interacting proteins for CYP4A22 (ENSP000003609584) via UniProtKB, MINT, STRING, and/or I2D (see all 73)About this table
|
Drugs & Compounds
for CYP4A22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYP4A22
10/11 HMDB Compounds for CYP4A22 (see all 11) About this table
Search CenterWatch for drugs/clinical trials and news about CYP4A22 / CP4AM
|
Transcripts
for CYP4A22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP4A22 gene: NM_001010969.2 5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000490948 ENST00000485117 ENST00000371890 ENST00000294337(uc009vyo.3 uc009vyp.3)
ENST00000371891(uc001cqv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4A22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP4A22 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP4A22 (NM_001010969) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP4A22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4A22 |
13 AceView cDNA sequences: BX116542 BV188293 BV202882 W85897 BV202881 W85981 BV202883 AY280371 AY280372 W86033 X71480 H81265 H81321
GeneLoc Exon Structure
|
Expression
for CYP4A22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP4A22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CYP4A22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4A22
SABiosciences Expression via Pathway-Focused PCR Array including CYP4A22:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP4A22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP4A22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4A22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4A22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4A22 |
Orthologs
for CYP4A22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYP4A22 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for CYP4A22 (if available)
TreeFam Gene Tree for CYP4A22 (if available) |
Paralogs
for CYP4A22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP4A22 gene
- CYP4F222 CYP4F32 CYP4F22 CYP4F112 CYP46A12 ENSG000002256072 CYP4B12 CYP3A52
- CYP4X12 TBXAS12 CYP3A42 CYP3A432 CYP3A72 CYP4V22 CYP4A112 CYP4F122
- CYP4Z12
14 SIMAP similar genes for CYP4A22 using alignment to 4 protein entries: CP4AM_HUMAN (see all proteins):CYP4A11 CYP4Z2P CYP4B1 DKFZp761K058 CYP4X1 CYP4Z1
CYP4F22 CYP4F8 CYP4F12 CYP4V2 CYP4F3 CYP4F11
CYP4F2 CYP3A5
CYP4A22 for paralogs About GeneDecksing
|
Genomic Variants
for CYP4A22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP4A22 (47603107 - 47615413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP4A22: --
Human Gene Mutation Database (HGMD): CYP4A22
Locus Specific Mutation Databases (LSDB): CYP4A22
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4A22 |
|
Disorders
/ Diseases
for CYP4A22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP4A22 for disorders About GeneDecksing
5  diseases for CYP4A22: About MalaCardsessential hypertension cholesterol hypertension tuberculosis
mycobacterium tuberculosis
Export disorders for CYP4A22 gene to outside databases
|
Publications
for CYP4A22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP4A22 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CYP4A22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PubMed id 15611369)1, 2 Gainer J.V.... Capdevila J.H. (2005)
- Molecular modeling study on orphan human protein CYP4 A22 for identification of potential ligand binding site. (PubMed id 20079672)1, 9 Gajendrarao P....Lee K.W. (2010)
- Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. (PubMed id 21820496)1 Lino Cardenas C.L....Chevalier D. (2011)
- Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population. (PubMed id 16806293)2 Hiratsuka M....Mizugaki M. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
- Characterization of the CYP4A11 gene, a second CYP4A gene in humans. (PubMed id 12464262)1 Bellamine A.... Capdevila J.H. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. (PubMed id 10860550)2 Kawashima H.... Kishimoto T. (2000)
|
External Searches for CYP4A22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP4A22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP4A22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP4A22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP4A22 | Pharmacogenomics, SNPs, Pathways | | Cytochrome P450 Allele Nomenclature Committee | http://www.cypalleles.ki.se/cyp4a22.htm |
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| | |
About This Section
| Patent Information for CYP4A22 gene:
Search GeneIP for patents involving CYP4A22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP4A22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP4A22 | | OriGene Custom Protein Services for CYP4A22 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP4A22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4A22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4A22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP4A22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4A22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4A22 |
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| |  |  |  |  | | | | |
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 | | | CYP4A22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4A22 |
|  |  |  | | | | Search ThermoFisher Antibodies for CYP4A22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP4A22 |
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