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CYP4A22 Gene

protein-coding   GIFtS: 50
GCID: GC01P047603

Cytochrome P450, Family 4, Subfamily A, Polypeptide 22

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 4, Subfamily A, Polypeptide 221 2     Cytochrome P450 4A222
Fatty Acid Omega-Hydroxylase2 3     Cytochrome P450 4A22K2
Lauric Acid Omega-Hydroxylase2 3     EC 1.14.15.33
CYPIVA222 3     

External Ids:    HGNC: 205751   Entrez Gene: 2845412   Ensembl: ENSG000001623657   OMIM: 6153415   UniProtKB: Q5TCH43   

Export aliases for CYP4A22 gene to outside databases

Previous GC identifers: GC00U916975 GC01P047314 GC01P047376 GC01P045719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP4A22 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CYP4A22 Gene:
CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4
Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate.
Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does
not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis

Gene Wiki entry for CYP4A22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CYP4A22 gene promoter:
         GR   AML1a   HTF   LCR-F1   SEF-1 (1)   GR-alpha   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4A22 promoter sequence
   Search Chromatin IP Primers for CYP4A22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP4A22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4A22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4A22 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047603:  view genomic region     (about GC identifiers)

Start:
47,603,107 bp from pter      End:
47,615,413 bp from pter
Size:
12,307 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4 (See protein sequence)
Recommended Name: Cytochrome P450 4A22 precursor  
Size: 519 amino acids; 59246 Da
Caution: Was originally (PubMed:10860550) termed CYP4A11
Secondary accessions: Q5TCH3 Q6JXK7 Q6JXK8 Q9NRM4
Alternative splicing: 2 isoforms:  Q5TCH4-1   Q5TCH4-2   

Explore the universe of human proteins at neXtProt for CYP4A22: NX_Q5TCH4

Explore proteomics data for CYP4A22 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP4A22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010969.2  
    ENSEMBL proteins: 
     ENSP00000360957   ENSP00000294337   ENSP00000360958  
    Reactome Protein details: Q5TCH4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4A22
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q5TCH4

    ProtoNet protein and cluster: Q5TCH4

    UniProtKB/Swiss-Prot: CP4AM_HUMAN, Q5TCH4
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP4A22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4AM_HUMAN, Q5TCH4
    Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate.
    Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does
    not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis
    Catalytic activity: Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=56.7 uM for laurate; Note=Vmax:15.2 umol/min/umol enzyme;

         Enzyme Number (IUBMB): EC 1.14.15.31

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0018685alkane 1-monooxygenase activity IEA--
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with CYP4A22           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP4A22
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    miRNA
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    miRTarBase miRNAs that target CYP4A22:
    hsa-mir-26b-5p (MIRT029322)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: CYP4A22 (NM_001010969)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP4AM_HUMAN, Q5TCH4: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome
    membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    peroxisome2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with CYP4A22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP4A22 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Miscellaneous substrates0.00
    cytochrome P4500.74
    Eicosanoids0.00
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Biological oxidations
    Biological oxidations0.56
    5Fatty acid metabolism
    Fatty acid degradation0.42


    Find genes that share SuperPaths with CYP4A22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CYP4A22
        cytochrome P450

    4 Reactome Pathways for CYP4A22
        Miscellaneous substrates
    Fatty acids
    Eicosanoids
    Synthesis of Leukotrienes (LT) and Eoxins (EX)


    2 Kegg Pathways  (Kegg details for CYP4A22):
        Fatty acid degradation
    Vascular smooth muscle contraction

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4A22: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP4A22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP4A22 (ENSP000003609584) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH3A2ENSP000003457744STRING: ENSP00000345774
    ALDH9A1ENSP000003468274STRING: ENSP00000346827
    ALOX12BENSP000003151674STRING: ENSP00000315167
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with CYP4A22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP4A22 (CP4AM)

    Selected HMDB Compounds for CYP4A22 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    20-Hydroxyeicosatetraenoic acid20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid (see all 15)79551-86-3--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OctaneOctane (see all 2)111-65-9--
    Octanol1-Hydroxyoctane (see all 34)111-87-5--
    OxygenOxygen (see all 5)7782-44-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP4A22 gene: 
    NM_001010969.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490948 ENST00000485117 ENST00000371890 ENST00000294337(uc009vyo.3 uc009vyp.3)
    ENST00000371891(uc001cqv.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CYP4A22

    13 AceView cDNA sequences:

    BV202881 BV202882 BX116542 W85897 BV188293 W85981 AY280372 AY280371 
    BV202883 W86033 X71480 H81321 H81265 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP4A22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP4A22 Expression
    About this image

    CYP4A22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP4A22 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including CYP4A22: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4A22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP4A22 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4a12b1 , 5 cytochrome P450, family 4, subfamily a, polypeptide more1, 5 79.62(n)1
    75.54(a)1
      4 (52.99 cM)5
    131181  NM_172306.21  NP_758510.21 
     1154116245 
    chicken
    (Gallus gallus)
    Aves CYP4B11 cytochrome P450, family 4, subfamily B, polypeptide more 61.93(n)
    55.2(a)
      424618  XM_422455.3  XP_422455.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    52(a)
    51(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343249.1(1942574-1982744)
    GL343249.1(1863196-1879999)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP715A11 CYP715A1 44.14(n)
    32.43(a)
      835316  NM_124619.2  NP_200053.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g08241001 Os02g0824100 43.96(n)
    28.06(a)
      4331202  NM_001055108.1  NP_001048573.1 


    ENSEMBL Gene Tree for CYP4A22 (if available)
    TreeFam Gene Tree for CYP4A22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP4A22 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    14 SIMAP similar genes for CYP4A22 using alignment to 4 protein entries:     CP4AM_HUMAN (see all proteins):
    CYP4A11    CYP4Z2P    CYP4B1    DKFZp761K058    CYP4X1    CYP4Z1
    CYP4F22    CYP4F2    CYP4F3    CYP4F8    CYP4F12    CYP4V2
    CYP4F11    CYP3A5

    Find genes that share paralogs with CYP4A22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP4A22 (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745772891,2
    C--45730564(-) CAAGTC/TCAGAC 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs610448591,2
    C--47601460(+) AAAAA-/ATCATG 1 -- us2k10--------
    rs341648331,2
    C--47603034(+) CCAAG-/TTCTGC 1 -- us2k13Minor allele frequency- T:0.10CSA 10
    rs349136631,2
    C--47603617(+) ATGGA-/GGGCAA 1 -- int10--------
    rs672727751,2
    C--47604531(+) GAGCA-/AGGTAA 1 -- int10--------
    rs93330391,2
    F--47614846(+) AAGCCC/TGGGGC 1 -- ds50014Minor allele frequency- T:0.02NS 180
    rs93330401,2
    C,F--47614909(+) GTCTGG/AACTTG 1 -- ds5001 ese35Minor allele frequency- A:0.31NS NA 186
    rs31769791,2
    C,F--47614918(+) TGCTGG/CCTCCT 1 -- ds50019Minor allele frequency- C:0.25NS NA MN WA 376
    rs1830056731,2
    --47678728(+) ACTTTG/TCTGAA 1 -- us2k10--------
    rs120493991,2
    C,A--47678869(+) acctgT/Gccaga 1 -- us2k14Minor allele frequency- G:0.15CSA WA NA EA 360

    HapMap Linkage Disequilibrium report for CYP4A22 (47603107 - 47615413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYP4A22:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv221n71CNV Gain21882294

    The Human Cytochrome P450 Allele Nomenclature Database: CYP4A22 
    Human Gene Mutation Database (HGMD): CYP4A22
    Locus Specific Mutation Databases (LSDB): CYP4A22

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615341    OMIM disorders: --


    Find genes that share disorders with CYP4A22           About GenesLikeMe


    Export disorders for CYP4A22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP4A22 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CYP4A22)
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    1. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PubMed id 15611369)1, 2 Gainer J.V.... Capdevila J.H. (Circulation 2005)
    2. Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. (PubMed id 10860550)1, 2 Kawashima H.... Kishimoto T. (Arch. Biochem. Biophys. 2000)
    3. Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site. (PubMed id 20079672)1, 9 Gajendrarao P....Lee K.W. (amp 2010)
    4. Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. (PubMed id 21820496)1 Lino Cardenas C.L....Chevalier D. (Gene 2011)
    5. Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population. (PubMed id 16806293)2 Hiratsuka M....Mizugaki M. (Mutat. Res. 2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)
    9. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. (PubMed id 12464262)1 Bellamine A.... Capdevila J.H. (Arch. Biochem. Biophys. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284541 HGNC: 20575 AceView: CYP4A22 Ensembl:ENSG00000162365 euGenes: HUgn284541
    ECgene: CYP4A22 Kegg: 284541 H-InvDB: CYP4A22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP4A22 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp4a22.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP4A22 gene:
    Search GeneIP for patents involving CYP4A22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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