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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP4A11 Gene

protein-coding GIFtS: 66
GCID: GC01M047394

cytochrome P450, family 4, subfamily A, polypeptide 11

(Previous names: cytochrome P450, subfamily IVA, polypeptide 11 )
(Previous symbol: CYP4A2)

Explore 12 diseases affiliated with
CYP4A11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 4, Subfamily A, Polypeptide 11¹ ²		20-HETE Synthase² ³
CYP4A2¹ ² ³		20-Hydroxyeicosatetraenoic Acid Synthase² ³
CYP4AII¹ ² ³		CYPIVA11² ³
Cytochrome P450, Subfamily IVA, Polypeptide 11¹ ²		CP4Y²
Cytochrome P-450HK-Omega² ³		P450HL-Omega¹
Cytochrome P450HL-Omega² ³		Alkane-1 Monooxygenase²
Fatty Acid Omega-Hydroxylase² ³		Cytochrome P450 4A11²
Lauric Acid Omega-Hydroxylase² ³		EC 1.14.15.3³

External Ids:	HGNC: 2642¹	Entrez Gene: 1579²	Ensembl: ENSG00000187048⁷	OMIM: 601310⁵	UniProtKB: Q02928³

Export aliases for CYP4A11 gene to outside databases

Previous GC identifers: GC01M047088 GC01M046351 GC01M046696 GC01M046764 GC01M047106 GC01M047167 GC01M045510

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP4A11:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as

laurate and myristate. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928

Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and

palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to

20-hydroxyeicosatetraenoic acid (20-HETE)

Gene Wiki entry for CYP4A11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP4A11 gene promoter:
GR AML1a AP-1 ATF-2 LCR-F1 c-Jun GR-alpha MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP4A11 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP4A11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4A11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33

CYP4A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4A11 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M047394: view genomic region (about GC identifiers)

Start:	47,394,846 bp from pter	End:	47,407,156 bp from pter
Size:	12,311 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928 (See protein sequence)

Recommended Name: Cytochrome P450 4A11 precursor

Size: 519 amino acids; 59348 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Secondary accessions: Q06766 Q16865 Q16866 Q5VSP8 Q86SU6 Q8IWY5

Alternative splicing: 2 isoforms: Q02928-1 Q02928-2

Explore the universe of human proteins at neXtProt for CYP4A11: NX_Q02928

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q02928

CYP4A11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000769.2

ENSEMBL proteins:

ENSP00000311095 ENSP00000360972 ENSP00000360971 ENSP00000406272

Reactome Protein details: Q02928
Human Recombinant Protein Products for CYP4A11:

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	Uscn Proteins for CYP4A11

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10660572
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0016324	apical plasma membrane	IDA	10660572
GO:0043231	intracellular membrane-bounded organelle	IDA	9618440

CYP4A11 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP4A11 for domains About GeneDecksing

3 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q02928

ProtoNet protein and cluster: Q02928

1 Blocks protein family: IPB002402 Group II E-class P450 signature

UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP4AB_HUMAN, Q02928

Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and

palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to

20-hydroxyeicosatetraenoic acid (20-HETE)

Catalytic activity: Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O

Genatlas biochemistry entry for CYP4A11:

cytochrome p450,subfamily IVA,polypeptide 11

Enzyme Number (IUBMB): EC 1.14.15.3¹

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0008392	arachidonic acid epoxygenase activity	IDA	9618440
GO:0009055	electron carrier activity	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--

CYP4A11 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cyp4a10):

cardiovascular system

homeostasis/metabolism

renal/urinary system

CYP4A11 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cyp4a10^tm1Jhc for CYP4A11

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYP4A11

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4A11

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Arachidonic acid metabolism

	Arachidonic acid metabolism	1.00			HETE and HPETE biosynthesis and metabolism	0.39
	Arachidonic acid metabolism	0.42			HETE and HPETE biosynthesis and metabolism	0.39

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Retinol metabolism

Retinol metabolism

1.00

Retinol metabolism

0.95

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CYP4A11

	Retinol metabolism
	HETE and HPETE biosynthesis and metabolism

2 GeneGo (Thomson Reuters) Pathways for CYP4A11

	Retinol metabolism
	HETE and HPETE biosynthesis and metabolism

3 BioSystems Pathways for CYP4A11

	cytochrome P450
	Nuclear receptors in lipid metabolism and toxicity
	Fatty Acid Omega Oxidation

5/12 Reactome Pathways for CYP4A11 (see all 12)

	Cytochrome P450 - arranged by substrate type
	Fatty acids
	Metabolism
	Arachidonic acid metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism

5/6 Kegg Pathways (Kegg details for CYP4A11) (see all 6):

	Fatty acid metabolism
	Arachidonic acid metabolism
	Retinol metabolism
	Metabolic pathways
	PPAR signaling pathway

CYP4A11 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP4A11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/76 Interacting proteins for CYP4A11 (Q02928³ ENSP00000311095⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986³, ENSP00000274335⁴	I2D: score=1 STRING: ENSP00000274335
PIK3R5	Q8WYR1³, ENSP00000269300⁴	I2D: score=1 STRING: ENSP00000269300
ALDH9A1	ENSP00000346827⁴	STRING: ENSP00000346827
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050
CYP1A2	ENSP00000342007⁴	STRING: ENSP00000342007

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001676	long-chain fatty acid metabolic process	IDA	18433732
GO:0003091	renal water homeostasis	IEP	10660572
GO:0003095	pressure natriuresis	IEP	10660572
GO:0006631	fatty acid metabolic process	TAS	7679927
GO:0006691	leukotriene metabolic process	IDA	9799565

CYP4A11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP4A11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP4A11

10/11 HMDB Compounds for CYP4A11 (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
20-Hydroxyeicosatetraenoic acid	20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid (see all 15)	79551-86-3	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Octane	Octane (see all 2)	111-65-9	--
Octanol	1-Hydroxyoctane (see all 34)	111-87-5	--
Oxygen	Oxygen (see all 5)	7782-44-7	--

10/12 DrugBank Compounds for CYP4A11 (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17139284 11246504 17016423
Cisplatin	Cis-DDP (see all 4)	15663-27-1	enzyme	inducer	9523352
Clofibrate	Chlorfenisate (see all 11)	637-07-0	enzyme	substrate inducer	19934256
Dexamethasone	Desametasone (see all 9)	50-02-2	enzyme	inducer	19934256
Estrone	--	53-16-7	enzyme	substrate	19934256
Ethanol	Absolute Alcohol (see all 34)	64-17-5	enzyme	inducer	19934256
Lansoprazole	--	103577-45-3	enzyme	inducer	19934256
Pegvisomant	GH (see all 6)	218620-50-9	enzyme	inhibitor	19366684
Pentamidine	1,3-bis(4-amidinophenoxy)pentane (see all 5)	100-33-4	enzyme	substrate	12920490
Phenobarbital	Fenobarbital (see all 7)	50-06-6	enzyme	inducer	19934256

10/12 Novoseek chemical compound relationships for CYP4A11 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lauric acid	90.6	20	8914854 (6), 7798189 (1), 7657063 (1), 9744576 (1) (see all 13)
20-hydroxyeicosatetraenoic acid	85.8	13	9618440 (5), 10660572 (2), 18300855 (1), 16141533 (1) (see all 6)
pga1	78.9	2	18566475 (1), 10860550 (1)
arachidonic acid	64.7	12	9618440 (3), 10660572 (2), 18300855 (1), 10860550 (1) (see all 6)
fatty acid	62	29	1739747 (5), 1587824 (2), 19661213 (2), 8274222 (2) (see all 15)
chlorzoxazone	59.4	2	9744576 (1), 9352574 (1)
palmitate	53.1	1	15056802 (1)
tolbutamide	45.2	2	9744576 (1), 9352574 (1)
coumarin	38.8	2	9744576 (1), 9352574 (1)
nadph	30.8	1	9722531 (1)

Search CenterWatch for drugs/clinical trials and news about CYP4A11 / CP4AB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP4A11 gene:

NM_000778.3

Unigene Clusters for CYP4A11:

Cytochrome P450, family 4, subfamily A, polypeptide 11

Hs.1645 [show with all ESTs], Hs.726474 [show with all ESTs]

Unigene Representative Sequences: L04751, BC142607

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310638(uc001cqp.4) ENST00000475477 ENST00000462347 ENST00000474458

ENST00000468629(uc010omm.1) ENST00000465874(uc001cqq.2) ENST00000371905

ENST00000496519 ENST00000371904 ENST00000457840

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Additional cDNA sequence:

AY280371.1 AY280372.1 BC142607.1 BC142690.1 BC148248.1 X71480.1

12 DOTS entries:

DT.111873 DT.102820356 DT.100739479 DT.100751984 DT.407109 DT.121374415 DT.95157824 DT.101983006

DT.101983007 DT.121374416 DT.101983010 DT.101983012

24/42 AceView cDNA sequences (see all 42):

CD013975 CD013979 BC041158 BF594611 BI759809 CD013980 AA877140 BI759294

AI565414 CD014132 BX452362 BX422210 BV202872 S67580 L04751 AI078080

CD013978 D13705 AI261826 BC022851 BV202873 AI580360 AW780002 CD013977

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP4A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAAGTCCT

About this image
See CYP4A11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP4A11

SOURCE GeneReport for Unigene clusters: Hs.1645 Hs.726474

UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928

Tissue specificity: Kidney and liver

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP4A11:

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

PPAR Targets in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP4A11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4A11 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NNP0_CHICK⁶	Uncharacterized protein	55(a)	1 → many	8(22606274-22613175)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 6)	--	56(a) 56(a) (see all 6)	many ↔ many many ↔ many (see all 6)	GL343249.1(1807780-1829271) GL343249.1(1946154-1981895)
African clawed frog (Xenopus laevis)	Amphibia	cypxl301-A-prov²	cytochrome P450 XL-301	76.46(n)		AB022672.1
zebrafish (Danio rerio)	Actinopterygii	BC056734.1²	--	76.88(n)		387527 BC056734.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP002417¹	AGAP002417-PA	48.01(n) 36.32(a)		1273546 XM_001237477.2 XP_001237478.2
thale cress (Arabidopsis thaliana)	eudicotyledons	CYP72A15⁶ CYP72A14⁶ (see all 22)	cytochrome P450, family 72, subfamily A, polypepti... cytochrome P450, family 72, subfamily A, polypepti... (see all 22)	21(a) 20(a) (see all 22)	possible ortholog possible ortholog (see all 22)	3(4937317-4939465) 3(4934420-4936563)
rice (Oryza sativa)	Liliopsida	-- -- (see all 42)	cytochrome P450 72A1, putative, expressed (see all 42)	26(a) 25(a) (see all 42)	possible ortholog possible ortholog (see all 42)	12(909825-911396) 7(26374654-26376646)

ENSEMBL Gene Tree for CYP4A11 (if available)
TreeFam Gene Tree for CYP4A11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CYP4A11 gene

CYP4F22² CYP4F3² CYP4F2² CYP4F11² CYP46A1² ENSG00000225607² CYP4B1² CYP3A5²

CYP4X1² TBXAS1² CYP3A4² CYP3A43² CYP3A7² CYP4V2² CYP4A22² CYP4F12²

CYP4Z1²

18/22 SIMAP similar genes for CYP4A11 using alignment to 3 protein entries: CP4AB_HUMAN (see all proteins) (see all similar genes):

CYP4A22 CYP4X1 CYP4Z1 CYP4Z2P CYP4B1 CYP4F22

CYP4F2 CYP4F3 CYP4F12 CYP4F8 CYP4F11 CYP3A43

CYP3A4 CYP3A43/CYP3A4 DKFZp761K058 CYP4V2 CYP3A5 CYP1B1

CYP4A11 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CYP4A11
PGOHUM00000244007

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928

Polymorphism: CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize

lauric acid

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74072420^1,2	C	--	45510515(+)	`GAGAGA/TTTTAG`	1	--	ds500¹		2		WA	120
rs113849111^1,2		--	45510599(+)	`TAATTC/TATGAA`	1	--	ds500¹		1		CSA	2
rs111621534^1,2		--	45510991(+)	`TCACTG/AAGATT`	1	--	ut3¹		1		CSA	2
rs9333055^1,2	C,F	--	45511091(-)	`CCTGCC/TCTCCA`	1	--	ut3¹ ese³		4		NS	176
rs9333054^1,2	C,F,H	--	45511139(-)	`CTGAAC/AACCCC`	1	--	ut3¹ ese³		8		NS EA	596
rs9333053^1,2	C,F	--	45511140(-)	`TCTGAA/TCACCC`	1	--	ut3¹ ese³		4		NS	184
rs9333052^1,2	C,F	--	45511191(-)	`TCACTG/CCTTTG`	1	--	ut3¹ ese³		4		NS	184
rs9333051^1,2	C,F	--	45511193(-)	`TCTCAC/TTGCTT`	1	--	ut3¹ ese³		4		NS	184
rs9333062^1,2	F	--	45511233(-)	`TTTGGC/TGCCCT`	2	--	ut3¹		4		NS	184
rs113060578^1,2	C	--	45511233(-)	`TTTGGC/TGCCCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP4A11 (47394846 - 47407156 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP4A11: --
Human Gene Mutation Database (HGMD): CYP4A11

Locus Specific Mutation Databases (LSDB): CYP4A11

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP4A11

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP4A11 for disorders           About GeneDecksing

OMIM gene information: 601310    OMIM disorders: --

12 diseases for CYP4A11:    About MalaCards

cholesterol fatty liver disease hearing loss essential hypertension

myocardial infarction liver disease cerebral infarction hypertension

cerebritis tuberculosis hepatitis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for CYP4A11:

Hypertension

Genetic Association Database (GAD): CYP4A11
Human Genome Epidemiology (HuGE) Navigator: CYP4A11 (16 documents)

Export disorders for CYP4A11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP4A11 gene, integrated from 9 sources (see all 89):
(articles sorted by number of sources associating them with CYP4A11)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. (PubMed id 7679927)^{1, 2, 3, 9} Palmer C.N.A.... Johnson E.F. (1993)
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PubMed id 15611369)^{1, 2, 4} Gainer J.V.... Capdevila J.H. (2005)
Opposing roles of peroxisome proliferator-activated r eceptor alpha and growth hormone in the regulation of CYP4A11 expression in a t ransgenic mouse model. (PubMed id 19366684)^{1, 7, 9} Savas U....Johnson E.F. (2009)
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney. (PubMed id 8274222)^{1, 2, 9} Imaoka S.... Gonzalez F.J. (1993)
Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. (PubMed id 1739747)^{1, 2, 9} Kawashima H.... Kusunose M. (1992)
Purification and cDNA cloning of human liver CYP4A fatty acid omega- hydroxylase. (PubMed id 7798189)^{1, 2, 9} Kawashima H.... Kusunose M. (1994)
Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. (PubMed id 16144986)^{1, 4} Mayer B....Erdmann J. (2005)
Characterization of the CYP4A11 gene, a second CYP4A gene in humans. (PubMed id 12464262)^{1, 2} Bellamine A.... Capdevila J.H. (2003)
Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family. (PubMed id 11821421)^{1, 2} LeBrun L.A.... Ortiz de Montellano P.R. (2002)
Covalently linked heme in cytochrome P4504A fatty acid hydroxylases. (PubMed id 11139583)^{1, 2} Hoch U. and Ortiz de Montellano P.R. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1579	HGNC: 2642	AceView: CYP4A11	Ensembl:ENSG00000187048	euGenes: HUgn1579
ECgene: CYP4A11	Kegg: 1579	H-InvDB: CYP4A11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP4A11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP4A11	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp4a11.htm
SeattleSNPs	http://pga.gs.washington.edu/data/cyp4a11/

Intellectual Property for CYP4A11 gene
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CYP4A11 Gene

cytochrome P450, family 4, subfamily A, polypeptide 11

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CYP4A11 Gene

cytochrome P450, family 4, subfamily A, polypeptide 11

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