Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYP4A11 Gene

Aliases for CYP4A11 Gene

  • Cytochrome P450, Family 4, Subfamily A, Polypeptide 11 2 3
  • Cytochrome P450, Subfamily IVA, Polypeptide 11 2 3
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Lauric Acid Omega-Hydroxylase 3 4
  • Fatty Acid Omega-Hydroxylase 3 4
  • Cytochrome P-450HK-Omega 3 4
  • Cytochrome P450HL-Omega 3 4
  • 20-HETE Synthase 3 4
  • CYPIVA11 3 4
  • CYP4AII 3 4
  • CYP4A2 3 4
  • Alkane-1 Monooxygenase 3
  • Cytochrome P450 4A11 3
  • P450HL-Omega 3
  • EC 1.14.15.3 4
  • CP4Y 3

External Ids for CYP4A11 Gene

Previous HGNC Symbols for CYP4A11 Gene

  • CYP4A2

Previous GeneCards Identifiers for CYP4A11 Gene

  • GC01M047088
  • GC01M046351
  • GC01M046696
  • GC01M046764
  • GC01M047106
  • GC01M047167
  • GC01M047394
  • GC01M045510

Summaries for CYP4A11 Gene

Entrez Gene Summary for CYP4A11 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4A11 Gene

CYP4A11 (Cytochrome P450, Family 4, Subfamily A, Polypeptide 11) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP4A11 Gene

  • Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Gene Wiki entry for CYP4A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4A11 Gene

Genomics for CYP4A11 Gene

Regulatory Elements for CYP4A11 Gene

Genomic Location for CYP4A11 Gene

Start:
46,929,174 bp from pter
End:
46,941,484 bp from pter
Size:
12,311 bases
Orientation:
Minus strand

Genomic View for CYP4A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4A11 Gene

Proteins for CYP4A11 Gene

  • Protein details for CYP4A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02928-CP4AB_HUMAN
    Recommended name:
    Cytochrome P450 4A11
    Protein Accession:
    Q02928
    Secondary Accessions:
    • Q06766
    • Q16865
    • Q16866
    • Q5VSP8
    • Q86SU6
    • Q8IWY5

    Protein attributes for CYP4A11 Gene

    Size:
    519 amino acids
    Molecular mass:
    59348 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4A11 Gene

Proteomics data for CYP4A11 Gene at MOPED

Post-translational modifications for CYP4A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4A11 Gene

No data available for DME Specific Peptides for CYP4A11 Gene

Domains for CYP4A11 Gene

Gene Families for CYP4A11 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP4A11 Gene

Suggested Antigen Peptide Sequences for CYP4A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02928

UniProtKB/Swiss-Prot:

CP4AB_HUMAN :
  • Q02928
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4A11: view

Function for CYP4A11 Gene

Molecular function for CYP4A11 Gene

GENATLAS Biochemistry: cytochrome p450,subfamily IVA,polypeptide 11
UniProtKB/Swiss-Prot CatalyticActivity: Octane + 2 reduced rubredoxin + O(2) + 2 H(+) = 1-octanol + 2 oxidized rubredoxin + H(2)O.
UniProtKB/Swiss-Prot Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Enzyme Numbers (IUBMB) for CYP4A11 Gene

Gene Ontology (GO) - Molecular Function for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IDA 9618440
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0018685 alkane 1-monooxygenase activity IDA 18433732
genes like me logo Genes that share ontologies with CYP4A11: view
genes like me logo Genes that share phenotypes with CYP4A11: view

Animal Models for CYP4A11 Gene

MGI Knock Outs for CYP4A11:

Animal Model Products

CRISPR Products

miRNA for CYP4A11 Gene

miRTarBase miRNAs that target CYP4A11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4A11

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CYP4A11 Gene

Localization for CYP4A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4A11 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4A11 Gene COMPARTMENTS Subcellular localization image for CYP4A11 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
golgi apparatus 2
peroxisome 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10660572
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016324 apical plasma membrane IDA 10660572
GO:0043231 intracellular membrane-bounded organelle IDA 10660572
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CYP4A11: view

Pathways for CYP4A11 Gene

genes like me logo Genes that share pathways with CYP4A11: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IDA 18433732
GO:0003091 renal water homeostasis IEP 10660572
GO:0003095 pressure natriuresis IEP 10660572
GO:0006631 fatty acid metabolic process TAS 7679927
GO:0006691 leukotriene metabolic process IDA 9799565
genes like me logo Genes that share ontologies with CYP4A11: view

Compounds for CYP4A11 Gene

(11) HMDB Compounds for CYP4A11 Gene

Compound Synonyms Cas Number PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
79551-86-3
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Heme
  • (protoporphyrinato)iron
14875-96-8
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4

(12) Drugbank Compounds for CYP4A11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cisplatin
  • CDDP
15663-27-1 enzyme inducer
Clofibrate
  • Chlorfenisate
637-07-0 enzyme substrate inducer
Dexamethasone
  • Desametasone
50-02-2 enzyme inducer
Estrone
53-16-7 enzyme substrate
Ethanol
  • Absolute Alcohol
64-17-5 enzyme inducer

(12) Novoseek inferred chemical compound relationships for CYP4A11 Gene

Compound -log(P) Hits PubMed IDs
lauric acid 90.6 18
20-hydroxyeicosatetraenoic acid 85.8 11
pga1 78.9 2
arachidonic acid 64.7 9
fatty acid 62 24
genes like me logo Genes that share compounds with CYP4A11: view

Transcripts for CYP4A11 Gene

Unigene Clusters for CYP4A11 Gene

Cytochrome P450, family 4, subfamily A, polypeptide 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4A11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4A11 Gene

No ASD Table

Relevant External Links for CYP4A11 Gene

GeneLoc Exon Structure for
CYP4A11
ECgene alternative splicing isoforms for
CYP4A11

Expression for CYP4A11 Gene

mRNA expression in normal human tissues for CYP4A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4A11 Gene

This gene is overexpressed in Liver (35.1) and Kidney - Cortex (17.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP4A11 Gene

SOURCE GeneReport for Unigene cluster for CYP4A11 Gene Hs.1645

mRNA Expression by UniProt/SwissProt for CYP4A11 Gene

Q02928-CP4AB_HUMAN
Tissue specificity: Kidney and liver.
genes like me logo Genes that share expressions with CYP4A11: view

In Situ Assay Products

Orthologs for CYP4A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4A11 36
  • 99 (a)
OneToOne
LOC739864 35
  • 99.05 (n)
  • 98.68 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
CYP4A22 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
ManyToMany
CYP4A37 36
  • 79 (a)
ManyToMany
CYP4A38 36
  • 78 (a)
ManyToMany
CYP4A39 36
  • 78 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4a10 35
  • 79.27 (n)
  • 77.56 (a)
Cyp4a10 16
Cyp4a10 36
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp4a1 35
  • 79.4 (n)
  • 77.17 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia cypxl301-A-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11716 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp4ae1 37
  • 28 (a)
Cyp4d2 37
  • 36 (a)
Cyp4e3 37
  • 32 (a)
Cyp4d8 37
  • 32 (a)
Cyp4s3 37
  • 37 (a)
Cyp4p1 37
  • 29 (a)
Cyp4d1 37
  • 33 (a)
Cyp313b1 37
  • 24 (a)
Cyp4d20 37
  • 33 (a)
Cyp4c3 37
  • 33 (a)
Cyp4e1 37
  • 29 (a)
Cyp311a1 37
  • 32 (a)
Cyp4g1 37
  • 27 (a)
Cyp4p2 37
  • 28 (a)
Cyp4ac1 37
  • 30 (a)
Cyp4ad1 37
  • 31 (a)
Cyp4d21 37
  • 31 (a)
Cyp4d14 37
  • 34 (a)
Cyp4g15 37
  • 39 (a)
Cyp312a1 37
  • 29 (a)
Cyp4p3 37
  • 30 (a)
Cyp4e2 37
  • 32 (a)
Cyp4ac2 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea F01D5.9 37
  • 34 (a)
Y80D3A.5 37
  • 35 (a)
F28G4.1 37
  • 30 (a)
Y17G9B.3 37
  • 33 (a)
B0331.1 37
  • 31 (a)
Y38C9B.1 37
  • 34 (a)
Species with no ortholog for CYP4A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4A11 Gene

ENSEMBL:
Gene Tree for CYP4A11 (if available)
TreeFam:
Gene Tree for CYP4A11 (if available)

Paralogs for CYP4A11 Gene

Pseudogenes.org Pseudogenes for CYP4A11 Gene

genes like me logo Genes that share paralogs with CYP4A11: view

Variants for CYP4A11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4A11 Gene

Q02928-CP4AB_HUMAN
CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid

Sequence variations from dbSNP and Humsavar for CYP4A11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1126742 - 46,932,824(-) CCCTT(C/T)CCGTT missense, reference, nc-transcript-variant
rs1126743 -- 46,930,301(-) TGCAT(C/G/T)GGGAA reference, missense, synonymous-codon, nc-transcript-variant
rs2269231 -- 46,935,752(+) GTAGC(A/T)TGCAG intron-variant
rs2269232 -- 46,935,794(+) GCAGA(C/T)GCATT intron-variant
rs3886078 -- 46,940,278(-) TTGAG(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4A11 Gene

Variant ID Type Subtype PubMed ID
dgv220n71 CNV Gain 21882294

Relevant External Links for CYP4A11 Gene

HapMap Linkage Disequilibrium report
CYP4A11
Human Gene Mutation Database (HGMD)
CYP4A11
Locus Specific Mutation Databases (LSDB)
CYP4A11
The Human Cytochrome P450 Allele Nomenclature Database
CYP4A11

Disorders for CYP4A11 Gene

(1) University of Copenhagen DISEASES for CYP4A11 Gene

Relevant External Links for CYP4A11

Genetic Association Database (GAD)
CYP4A11
Human Genome Epidemiology (HuGE) Navigator
CYP4A11
genes like me logo Genes that share disorders with CYP4A11: view

No data available for UniProtKB/Swiss-Prot for CYP4A11 Gene

Publications for CYP4A11 Gene

  1. Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. (PMID: 7679927) Palmer C.N.A. … Johnson E.F. (Biochim. Biophys. Acta 1993) 2 3 4 23
  2. Purification and cDNA cloning of human liver CYP4A fatty acid omega- hydroxylase. (PMID: 7798189) Kawashima H. … Kusunose M. (J. Biochem. 1994) 3 4 23
  3. Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney. (PMID: 8274222) Imaoka S. … Gonzalez F.J. (DNA Cell Biol. 1993) 3 4 23
  4. Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. (PMID: 1739747) Kawashima H. … Kusunose M. (Biochim. Biophys. Acta 1992) 3 4 23
  5. Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction. (PMID: 16957555) Mayer B. … Schunkert H. (J. Hypertens. 2006) 3 23 48

Products for CYP4A11 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP4A11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4A11
    • Block miRNA regulation of CYP4A11 using miScript Target Protectors
    • antibodies-online proteins for CYP4A11
    • antibodies-online antibodies for CYP4A11
    • antibodies-online kits for CYP4A11

    Sources for CYP4A11 Gene

    Back to Top

    Content