Aliases for CYP4A11 Gene
External Ids for CYP4A11 Gene
Previous HGNC Symbols for CYP4A11 Gene
Previous GeneCards Identifiers for CYP4A11 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP4A11 Gene
CYP4A11 (Cytochrome P450, Family 4, Subfamily A, Polypeptide 11) is a Protein Coding gene. Diseases associated with CYP4A11 include generalized atherosclerosis and hypertension, essential. Among its related pathways are Metabolism and Oxytocin signaling pathway. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F12.
UniProtKB/Swiss-Prot for CYP4A11 Gene
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).