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Aliases for CYP4A11 Gene

Aliases for CYP4A11 Gene

  • Cytochrome P450 Family 4 Subfamily A Member 11 2 3 5
  • Cytochrome P450, Family 4, Subfamily A, Polypeptide 11 2 3
  • Cytochrome P450, Subfamily IVA, Polypeptide 11 2 3
  • Long-Chain Fatty Acid Omega-Monooxygenase 3 4
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Lauric Acid Omega-Hydroxylase 3 4
  • Fatty Acid Omega-Hydroxylase 3 4
  • Cytochrome P-450HK-Omega 3 4
  • Cytochrome P450HL-Omega 3 4
  • 20-HETE Synthase 3 4
  • CYPIVA11 3 4
  • CYP4AII 3 4
  • CYP4A2 3 4
  • Alkane-1 Monooxygenase 3
  • EC 1.14.13.205 4
  • P450HL-Omega 3
  • CP4Y 3

External Ids for CYP4A11 Gene

Previous HGNC Symbols for CYP4A11 Gene

  • CYP4A2

Previous GeneCards Identifiers for CYP4A11 Gene

  • GC01M047088
  • GC01M046351
  • GC01M046696
  • GC01M046764
  • GC01M047106
  • GC01M047167
  • GC01M047394
  • GC01M045510

Summaries for CYP4A11 Gene

Entrez Gene Summary for CYP4A11 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP4A11 Gene

CYP4A11 (Cytochrome P450 Family 4 Subfamily A Member 11) is a Protein Coding gene. Diseases associated with CYP4A11 include generalized atherosclerosis. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP4A11 Gene

  • Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Gene Wiki entry for CYP4A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4A11 Gene

Genomics for CYP4A11 Gene

Regulatory Elements for CYP4A11 Gene

Genomic Location for CYP4A11 Gene

Chromosome:
1
Start:
46,929,174 bp from pter
End:
46,941,499 bp from pter
Size:
12,326 bases
Orientation:
Minus strand

Genomic View for CYP4A11 Gene

Genes around CYP4A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4A11 Gene

Proteins for CYP4A11 Gene

  • Protein details for CYP4A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02928-CP4AB_HUMAN
    Recommended name:
    Cytochrome P450 4A11
    Protein Accession:
    Q02928
    Secondary Accessions:
    • Q06766
    • Q16865
    • Q16866
    • Q5VSP8
    • Q86SU6
    • Q8IWY5

    Protein attributes for CYP4A11 Gene

    Size:
    519 amino acids
    Molecular mass:
    59348 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4A11 Gene

Proteomics data for CYP4A11 Gene at MOPED

Post-translational modifications for CYP4A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CYP4A11 Gene

Domains & Families for CYP4A11 Gene

Gene Families for CYP4A11 Gene

Protein Domains for CYP4A11 Gene

Suggested Antigen Peptide Sequences for CYP4A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02928

UniProtKB/Swiss-Prot:

CP4AB_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4A11: view

Function for CYP4A11 Gene

Molecular function for CYP4A11 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily IVA,polypeptide 11
UniProtKB/Swiss-Prot CatalyticActivity:
A long-chain fatty acid + NADPH + O(2) = an omega-hydroxy-long-chain fatty acid + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Enzyme Numbers (IUBMB) for CYP4A11 Gene

Gene Ontology (GO) - Molecular Function for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008392 arachidonic acid epoxygenase activity IDA 9618440
genes like me logo Genes that share ontologies with CYP4A11: view

Phenotypes for CYP4A11 Gene

GenomeRNAi human phenotypes for CYP4A11:
genes like me logo Genes that share phenotypes with CYP4A11: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4A11 Gene

Localization for CYP4A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4A11 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4A11 Gene COMPARTMENTS Subcellular localization image for CYP4A11 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
golgi apparatus 2
peroxisome 2
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4A11 Gene

Pathways & Interactions for CYP4A11 Gene

genes like me logo Genes that share pathways with CYP4A11: view

Gene Ontology (GO) - Biological Process for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process IDA 9799565
GO:0006805 xenobiotic metabolic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0097267 omega-hydroxylase P450 pathway TAS --
genes like me logo Genes that share ontologies with CYP4A11: view

No data available for SIGNOR curated interactions for CYP4A11 Gene

Drugs & Compounds for CYP4A11 Gene

(23) Drugs for CYP4A11 Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist, Enzyme, inducer 1909
Ethanol Approved Pharma Enzyme, inducer 1839
Cisplatin Approved Pharma Enzyme, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Clofibrate Approved Pharma Agonist, Enzyme, substrate, inducer 2
Pentamidine Approved Pharma Enzyme, substrate 39

(12) Additional Compounds for CYP4A11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11,12-EpETrE
  • (+/-)11(12)-EET
  • (+/-)11(12)-EpETrE
  • (+/-)11,12-EpETrE
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
all-trans-18-Hydroxyretinoic acid
  • 18-Hydroxy-all-trans-retinoate
  • 18-Hydroxy-all-trans-retinoic acid
  • Rac-18-hydroxy-all-trans-retinoate
  • Rac-18-hydroxy-all-trans-retinoic acid
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with CYP4A11: view

Transcripts for CYP4A11 Gene

Unigene Clusters for CYP4A11 Gene

Cytochrome P450, family 4, subfamily A, polypeptide 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4A11 Gene

No ASD Table

Relevant External Links for CYP4A11 Gene

GeneLoc Exon Structure for
CYP4A11
ECgene alternative splicing isoforms for
CYP4A11

Expression for CYP4A11 Gene

mRNA expression in normal human tissues for CYP4A11 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4A11 Gene

This gene is overexpressed in Liver (x35.1) and Kidney - Cortex (x17.2).

Protein differential expression in normal tissues from HIPED for CYP4A11 Gene

This gene is overexpressed in Gallbladder (41.9), Liver (14.7), Kidney (6.2), and Fetal Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4A11 Gene



SOURCE GeneReport for Unigene cluster for CYP4A11 Gene Hs.1645

mRNA Expression by UniProt/SwissProt for CYP4A11 Gene

Q02928-CP4AB_HUMAN
Tissue specificity: Kidney and liver.
genes like me logo Genes that share expression patterns with CYP4A11: view

Protein tissue co-expression partners for CYP4A11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CYP4A11 Gene

Orthologs for CYP4A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4A11 36
  • 99 (a)
OneToOne
LOC739864 35
  • 99.05 (n)
  • 98.68 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
CYP4A22 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
ManyToMany
CYP4A37 36
  • 79 (a)
ManyToMany
CYP4A38 36
  • 78 (a)
ManyToMany
CYP4A39 36
  • 78 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4a10 36
  • 77 (a)
ManyToMany
Cyp4a32 16
Cyp4a10 35
  • 79.27 (n)
  • 77.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp4a1 35
  • 79.4 (n)
  • 77.17 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia cypxl301-A-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11716 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp311a1 37
  • 32 (a)
Cyp312a1 37
  • 29 (a)
Cyp313b1 37
  • 24 (a)
Cyp4ac1 37
  • 30 (a)
Cyp4ac2 37
  • 29 (a)
Cyp4ad1 37
  • 31 (a)
Cyp4ae1 37
  • 28 (a)
Cyp4c3 37
  • 33 (a)
Cyp4d1 37
  • 33 (a)
Cyp4d14 37
  • 34 (a)
Cyp4d2 37
  • 36 (a)
Cyp4d20 37
  • 33 (a)
Cyp4d21 37
  • 31 (a)
Cyp4d8 37
  • 32 (a)
Cyp4e1 37
  • 29 (a)
Cyp4e2 37
  • 32 (a)
Cyp4e3 37
  • 32 (a)
Cyp4g1 37
  • 27 (a)
Cyp4g15 37
  • 39 (a)
Cyp4p1 37
  • 29 (a)
Cyp4p2 37
  • 28 (a)
Cyp4p3 37
  • 30 (a)
Cyp4s3 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea B0331.1 37
  • 31 (a)
F01D5.9 37
  • 34 (a)
F28G4.1 37
  • 30 (a)
Y17G9B.3 37
  • 33 (a)
Y38C9B.1 37
  • 34 (a)
Y80D3A.5 37
  • 35 (a)
Species with no ortholog for CYP4A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4A11 Gene

ENSEMBL:
Gene Tree for CYP4A11 (if available)
TreeFam:
Gene Tree for CYP4A11 (if available)

Paralogs for CYP4A11 Gene

Pseudogenes.org Pseudogenes for CYP4A11 Gene

genes like me logo Genes that share paralogs with CYP4A11: view

Variants for CYP4A11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4A11 Gene

Q02928-CP4AB_HUMAN
CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.

Sequence variations from dbSNP and Humsavar for CYP4A11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1126742 - 46,932,824(-) CCCTT(C/T)CCGTT nc-transcript-variant, reference, missense
VAR_044377 -
rs12759923 - 46,935,113(+) CCAGG(C/T)TGTTC intron-variant, nc-transcript-variant, reference, missense
rs1126743 -- 46,930,301(-) TGCAT(C/G/T)GGGAA nc-transcript-variant, reference, synonymous-codon
rs1419052 -- 46,934,208(-) ATCCA(C/T)GGCCT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CYP4A11 Gene

Variant ID Type Subtype PubMed ID
dgv220n71 CNV Gain 21882294

Variation tolerance for CYP4A11 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4A11 Gene

HapMap Linkage Disequilibrium report
CYP4A11
Human Gene Mutation Database (HGMD)
CYP4A11
The Human Cytochrome P450 Allele Nomenclature Database
CYP4A11

Disorders for CYP4A11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CYP4A11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
generalized atherosclerosis
  • generalised atherosclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP4A11

Genetic Association Database (GAD)
CYP4A11
Human Genome Epidemiology (HuGE) Navigator
CYP4A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4A11
genes like me logo Genes that share disorders with CYP4A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4A11 Gene

Publications for CYP4A11 Gene

  1. Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. (PMID: 7679927) Palmer C.N.A. … Johnson E.F. (Biochim. Biophys. Acta 1993) 2 3 4 23 67
  2. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. (PMID: 19366684) Savas U. … Johnson E.F. (J. Biol. Chem. 2009) 3 23 25
  3. SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. (PMID: 19934256) Preissner S. … Preissner R. (Nucleic Acids Res. 2010) 25 26
  4. A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men. (PMID: 18300855) Fu Z. … Ma Y. (J. Hypertens. 2008) 3 23
  5. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. (PMID: 18391101) Ward N.C. … Croft K.D. (Hypertension 2008) 3 23

Products for CYP4A11 Gene

Sources for CYP4A11 Gene

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