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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP4A11 Gene

protein-coding   GIFtS: 68
GCID: GC01M047394

Cytochrome P450, Family 4, Subfamily A, Polypeptide 11

(Previous names: cytochrome P450, subfamily IVA, polypeptide 11)
(Previous symbol: CYP4A2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 4, Subfamily A, Polypeptide 111 2     20-Hydroxyeicosatetraenoic Acid Synthase2 3
CYP4A21 2 3     CYP4AII2 3
Cytochrome P450, Subfamily IVA, Polypeptide 111 2     CYPIVA112 3
Cytochrome P-450HK-Omega2 3     CP4Y2
Cytochrome P450HL-Omega2 3     P450HL-omega2
Fatty Acid Omega-Hydroxylase2 3     Alkane-1 Monooxygenase2
Lauric Acid Omega-Hydroxylase2 3     Cytochrome P450 4A112
20-HETE Synthase2 3     EC 1.14.15.33

External Ids:    HGNC: 26421   Entrez Gene: 15792   Ensembl: ENSG000001870487   OMIM: 6013105   UniProtKB: Q029283   

Export aliases for CYP4A11 gene to outside databases

Previous GC identifers: GC01M047088 GC01M046351 GC01M046696 GC01M046764 GC01M047106 GC01M047167 GC01M045510


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP4A11 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids
such as laurate and myristate. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP4A11 Gene: 
CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) is a protein-coding gene. Diseases associated with CYP4A11 include cerebral infarction, and fatty liver disease, and among its related super-pathways are Arachidonic acid metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928
Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and
palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to
20-hydroxyeicosatetraenoic acid (20-HETE)

Gene Wiki entry for CYP4A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP4A11 gene promoter:
         GR   AML1a   AP-1   ATF-2   LCR-F1   c-Jun   GR-alpha   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP4A11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP4A11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP4A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

CYP4A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP4A11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047394:  view genomic region     (about GC identifiers)

Start:
47,394,846 bp from pter      End:
47,407,156 bp from pter
Size:
12,311 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928 (See protein sequence)
Recommended Name: Cytochrome P450 4A11 precursor  
Size: 519 amino acids; 59348 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: Q06766 Q16865 Q16866 Q5VSP8 Q86SU6 Q8IWY5
Alternative splicing: 2 isoforms:  Q02928-1   Q02928-2   

Explore the universe of human proteins at neXtProt for CYP4A11: NX_Q02928

Explore proteomics data for CYP4A11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02928

  • CYP4A11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP4A11 Protein Expression
    REFSEQ proteins: NP_000769.2  
    ENSEMBL proteins: 
     ENSP00000311095   ENSP00000360972   ENSP00000360971   ENSP00000406272  
    Reactome Protein details: Q02928
    Human Recombinant Protein Products for CYP4A11: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYP4A11 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10660572
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016324apical plasma membrane IDA10660572
    GO:0043231intracellular membrane-bounded organelle IDA10660572

    CYP4A11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP4A11 
    CYP4 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q02928

    ProtoNet protein and cluster: Q02928

    1 Blocks protein domain: IPB002402 Group II E-class P450 signature

    UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928
    Similarity: Belongs to the cytochrome P450 family


    CYP4A11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP4AB_HUMAN, Q02928
    Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and
    palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to
    20-hydroxyeicosatetraenoic acid (20-HETE)
    Catalytic activity: Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O

         Genatlas biochemistry entry for CYP4A11:
    cytochrome p450,subfamily IVA,polypeptide 11

         Enzyme Number (IUBMB): EC 1.14.15.31

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0008392arachidonic acid epoxygenase activity IDA9618440
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
         
    CYP4A11 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cyp4a10):
     cardiovascular system  homeostasis/metabolism  renal/urinary system 

    CYP4A11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cyp4a10tm1Jhc for CYP4A11

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP4A11 
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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP4A11 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.41
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    5Fatty acids
    Fatty acids0.50
    Miscellaneous substrates0.42
    Eicosanoids0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CYP4A11
        Retinol metabolism
    HETE and HPETE biosynthesis and metabolism


    2 GeneGo (Thomson Reuters) Pathways for CYP4A11
        Retinol metabolism
    HETE and HPETE biosynthesis and metabolism

    3 BioSystems Pathways for CYP4A11
        cytochrome P450
    Nuclear receptors in lipid metabolism and toxicity
    Fatty Acid Omega Oxidation

    5/14        Reactome Pathways for CYP4A11 (see all 14)
        Cytochrome P450 - arranged by substrate type
    Miscellaneous substrates
    Eicosanoids
    Fatty acids
    Metabolism


    5/6         Kegg Pathways  (Kegg details for CYP4A11) (see all 6):
        Fatty acid degradation
    Arachidonic acid metabolism
    Retinol metabolism
    Metabolic pathways
    PPAR signaling pathway


    CYP4A11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4A11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for CYP4A11 (Q029283 ENSP000003110954) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    PIK3R5Q8WYR13, ENSP000002693004I2D: score=1 STRING: ENSP00000269300
    ALDH9A1ENSP000003468274STRING: ENSP00000346827
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001676long-chain fatty acid metabolic process IDA18433732
    GO:0003091renal water homeostasis IEP10660572
    GO:0003095pressure natriuresis IEP10660572
    GO:0006631fatty acid metabolic process TAS7679927
    GO:0006691leukotriene metabolic process IDA9799565

    CYP4A11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP4A11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP4A11 (CP4AB)

    10/11 HMDB Compounds for CYP4A11 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    20-Hydroxyeicosatetraenoic acid20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid (see all 15)79551-86-3--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OctaneOctane (see all 2)111-65-9--
    Octanol1-Hydroxyoctane (see all 34)111-87-5--
    OxygenOxygen (see all 5)7782-44-7--

    10/12 DrugBank Compounds for CYP4A11 (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 11246504 17016423
    CisplatinCDDP (see all 7)15663-27-1enzymeinducer9523352
    ClofibrateChlorfenisate (see all 11)637-07-0enzymesubstrate inducer19934256
    DexamethasoneDesametasone (see all 9)50-02-2enzymeinducer19934256
    Estrone-- 53-16-7enzymesubstrate19934256
    EthanolAbsolute Alcohol (see all 34)64-17-5enzymeinducer19934256
    Lansoprazole-- 103577-45-3enzymeinducer19934256
    PegvisomantGH (see all 6)218620-50-9enzymeinhibitor19366684
    Pentamidine1,3-bis(4-amidinophenoxy)pentane (see all 5)100-33-4enzymesubstrate12920490
    PhenobarbitalFenobarbital (see all 7)50-06-6enzymeinducer19934256

    10/12 Novoseek inferred chemical compound relationships for CYP4A11 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lauric acid 90.6 20 8914854 (6), 7798189 (1), 7657063 (1), 9744576 (1) (see all 13)
    20-hydroxyeicosatetraenoic acid 85.8 13 9618440 (5), 10660572 (2), 18300855 (1), 16141533 (1) (see all 6)
    pga1 78.9 2 18566475 (1), 10860550 (1)
    arachidonic acid 64.7 12 9618440 (3), 10660572 (2), 18300855 (1), 10860550 (1) (see all 6)
    fatty acid 62 29 1739747 (5), 1587824 (2), 19661213 (2), 8274222 (2) (see all 15)
    chlorzoxazone 59.4 2 9744576 (1), 9352574 (1)
    palmitate 53.1 1 15056802 (1)
    tolbutamide 45.2 2 9744576 (1), 9352574 (1)
    coumarin 38.8 2 9744576 (1), 9352574 (1)
    nadph 30.8 1 9722531 (1)

    Search CenterWatch for drugs/clinical trials and news about CYP4A11 / CP4AB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP4A11 gene: 
    NM_000778.3  

    Unigene Clusters for CYP4A11:

    Cytochrome P450, family 4, subfamily A, polypeptide 11
    Hs.1645  [show with all ESTs], Hs.726474  [show with all ESTs]
    Unigene Representative Sequences: L04751, BC142607
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310638(uc001cqp.4) ENST00000475477 ENST00000462347 ENST00000474458
    ENST00000468629(uc010omm.1) ENST00000465874(uc001cqq.2) ENST00000371905
    ENST00000496519 ENST00000371904 ENST00000457840
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP4A11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP4A11

    Additional mRNA sequence: 

    AY280371.1 AY280372.1 BC142607.1 BC142690.1 BC148248.1 X71480.1 

    12 DOTS entries:

    DT.111873  DT.102820356  DT.100739479  DT.100751984  DT.407109  DT.121374415  DT.95157824  DT.101983006 
    DT.101983007  DT.121374416  DT.101983010  DT.101983012 

    24/42 AceView cDNA sequences (see all 42):

    CD013979 CD013980 CD013975 AI565414 BC041158 AA877140 BI759294 BI759809 
    BF594611 BX340590 D13705 CD014132 AI261826 NM_000778 AW780002 L04751 
    AI078080 CD013974 CD013978 CD013976 BG533264 BV202872 AI580360 D26481 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP4A11 expression in normal human tissues (normalized intensities)      CYP4A11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAGTCCT
    CYP4A11 Expression
    About this image


    CYP4A11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Liver (Hepatobiliary System)

    See CYP4A11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP4A11

    SOURCE GeneReport for Unigene clusters: Hs.1645 Hs.726474

    UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928
    Tissue specificity: Kidney and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP4A11: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CYP4A11 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp4a101 , 5 cytochrome P450, family 4, subfamily a, polypeptide more1, 5 79.27(n)1
    77.56(a)1
      4 (53.05 cM)5
    131171  NM_010011.31  NP_034141.31 
     1155182645 
    chicken
    (Gallus gallus)
    Aves --
    CYP4B16
    Uncharacterized protein
    56(a)
    55(a)
    possible ortholog
    possible ortholog
    8(20771032-20780775)
    8(20783471-20790800)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    57(a)
    53(a)
    (see all 6)
    possible ortholog
    many ↔ many
    (see all 6)
    GL343249.1(1803551-1829271)
    GL343249.1(1880734-1908444)
    African clawed frog
    (Xenopus laevis)
    Amphibia cypxl301-A-prov2 cytochrome P450 XL-301 76.46(n)    AB022672.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056734.12   -- 76.88(n)   387527  BC056734.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0024171 AGAP002417-PA 48.01(n)
    36.32(a)
      1273546  XM_001237477.2  XP_001237478.2 


    ENSEMBL Gene Tree for CYP4A11 (if available)
    TreeFam Gene Tree for CYP4A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP4A11 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP4B12  CYP3A52  CYP4Z12  CYP4F122  CYP4X12  
    18/21 SIMAP similar genes for CYP4A11 using alignment to 3 protein entries:     CP4AB_HUMAN (see all proteins) (see all similar genes):
    CYP4A22    CYP4X1    CYP4Z1    CYP4Z2P    CYP4B1    CYP4F22
    CYP4F2    CYP4F3    CYP4F12    CYP4F8    CYP4F11    CYP3A43
    CYP3A4    CYP3A43/CYP3A4    DKFZp761K058    CYP4V2    CYP3A5    CYP1B1

    CYP4A11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP4A11
    PGOHUM00000244007


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CP4AB_HUMAN, Q02928
    Polymorphism: CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to
    metabolize lauric acid


    10/455 SNPs in CYP4A11 are shown (see all 455)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0443774
    ----see VAR_0443772 S G mis40--------
    rs93330111,2
    F--45516403(-) GCTGAC/TGGTCT 1 -- int14Minor allele frequency- T:0.01NS 188
    rs675121441,2
    C--45518621(+) GTGTT-/TGTG  
            
    TGTGT
    1 -- int10--------
    rs1130605781,2
    C--47395103(-) TTTGGC/TGCCCT 1 -- ut310--------
    rs93330561,2
    C,F,H--47471834(-) CATACA/GTGATT 1 -- ds500128Minor allele frequency- G:0.05NS EA NA WA CSA 2299
    rs740724201,2
    C,F--47471863(+) GAGAGA/TTTTAG 1 -- ds50012Minor allele frequency- T:0.02WA 120
    rs1138491111,2
    C,F--47471947(+) TAATTC/TATGAA 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1829591371,2
    --47472156(+) GGACCG/TTACCA 1 -- ds50010--------
    rs1889289531,2
    --47472168(+) GGAATG/TCAAAA 1 -- ds50010--------
    rs1168199721,2
    F--47472248(+) GCCCTC/GTCCAG 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for CYP4A11 (47394846 - 47407156 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYP4A11:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv220n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): CYP4A11

    Locus Specific Mutation Databases (LSDB): CYP4A11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601310    OMIM disorders: --

    10 diseases for CYP4A11:    About MalaCards
    cerebral infarction    fatty liver disease    cytochrome p450    essential hypertension
    liver disease    hypertension    cerebritis    myocardial infarction
    tuberculosis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CYP4A11:
    Hypertension

    CYP4A11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYP4A11
    Human Genome Epidemiology (HuGE) Navigator: CYP4A11 (16 documents)

    Export disorders for CYP4A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP4A11 gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with CYP4A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. (PubMed id 7679927)1, 2, 3, 9 Palmer C.N.A.... Johnson E.F. (1993)
    2. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PubMed id 15611369)1, 2, 4 Gainer J.V.... Capdevila J.H. (2005)
    3. Opposing roles of peroxisome proliferator-activated r eceptor alpha and growth hormone in the regulation of CYP4A11 expression in a t ransgenic mouse model. (PubMed id 19366684)1, 7, 9 Savas U....Johnson E.F. (2009)
    4. Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney. (PubMed id 8274222)1, 2, 9 Imaoka S.... Gonzalez F.J. (1993)
    5. Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. (PubMed id 1739747)1, 2, 9 Kawashima H.... Kusunose M. (1992)
    6. A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men. (PubMed id 18300855)1, 4, 9 Fu Z....Ma Y. (2008)
    7. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. (PubMed id 18391101)1, 4, 9 Ward N.C....Croft K.D. (2008)
    8. Purification and cDNA cloning of human liver CYP4A fatty acid omega- hydroxylase. (PubMed id 7798189)1, 2, 9 Kawashima H.... Kusunose M. (1994)
    9. Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction. (PubMed id 16957555)1, 4, 9 Mayer B....Schunkert H. (2006)
    10. Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1579 HGNC: 2642 AceView: CYP4A11 Ensembl:ENSG00000187048 euGenes: HUgn1579
    ECgene: CYP4A11 Kegg: 1579 H-InvDB: CYP4A11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP4A11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP4A11 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp4a11.htm
    SeattleSNPshttp://pga.gs.washington.edu/data/cyp4a11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP4A11 gene:
    Search GeneIP for patents involving CYP4A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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