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CYP46A1 Gene

protein-coding GIFtS: 57

GC14P099220

cytochrome P450, family 46, subfamily A, polypeptide 1
(Previous names: cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP46)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CH24H ^³
CP46 ^²
CYP46 ^², ³, ⁵
EC 1.14.13.98 ^³

Descriptions
Cytochrome P450 46A1 ^³
cholesterol 24-hydroxylase ^²
cytochrome P450, family 46 ^²
cytochrome P450, family 46, subfamily A, polypeptide 1 ^²
cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) ^¹, ²

External Ids
HGNC: 2641¹
Entrez Gene: 10858²
UniProtKB: Q9Y6A2³
Ensembl: ENSG00000036530⁷

Search outside databases for aliases for CYP46A1 gene

Previous GC identifers: GC14P093966 GC14P098140

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CYP46A1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450

proteins are monooxygenases which catalyze many reactions involved in drug metabolism and

synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is

expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol

cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the

circulation to be returned to the liver for catabolism. [provided by RefSeq]

UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2

Function: Involved in the turnover of cholesterol. It converts cholesterol into

24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol

Gene Wiki entry for CYP46A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CYP46A1 gene

Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.1

CYP46A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P099220: (about GC identifiers)

Start:	99,220,407 bp from pter
End:	99,263,391 bp from pter
Size:	42,985 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2 (See protein sequence)

Recommended Name: Cholesterol 24-hydroxylase

Size: 500 amino acids; 56821 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome

membrane; Single-pass membrane protein

PDB structure from and Proteopedia :

2Q9F (3D)

2Q9G (3D)

REFSEQ proteins: NP_006659.1

ENSEMBL proteins:

ENSP00000369577 ENSP00000261835

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CYP46)
	Human Recombinant Proteins from Abnova (CYP46A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	10377398
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for CYP46A1:

	Invitrogen Antibodies for CYP46A1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CYP46A1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CYP46), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CYP46A1)
	Novus Biologicals Antibodies for CYP46A1

Assays for CYP46A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9Y6A2

ProtoNet protein and cluster: Q9Y6A2

UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2

Similarity: Belongs to the cytochrome P450 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP46A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP46A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006668

Applied Biosystems Silencer® siRNAs for CYP46A1

Sigma-Aldrich siRNA and siRNA Panels for CYP46A1

Sigma-Aldrich shRNA for CYP46A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CYP46A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006668
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006668
untagged cDNA clone in CMV expression vector: NM_006668

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006668

UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2

Function: Involved in the turnover of cholesterol. It converts cholesterol into

24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol

Catalytic activity: Cholesterol + NADPH + O(2) = (24S)-24-hydroxycholesterol + NADP(+) + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=2.2 uM for 24(S)-hydroxycholesterol;

Enzyme Number (IUBMB): EC 1.14.13.98

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cyp46a1):

homeostasis/metabolism

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008395	steroid hydroxylase activity	TAS	10377398
GO:0009055	electron carrier activity	IEA	--
GO:0020037	heme binding	IEA	--
GO:0033781	cholesterol 24-hydroxylase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for CYP46A1 (Your Favorite Gene powered by Ingenuity)

Ascorbate and Aldarate Metabolism
Sphingolipid Metabolism
Stilbene, Coumarine and Lignin Biosynthesis
Biosynthesis of Steroids

GeneDecks CYP46A1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CYP46A1

5/7 Interacting proteins for CYP46A1 (ENSP00000261835³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCA2	ENSP00000347205³	STRING (score=.828)
APOE	ENSP00000252486³	STRING (score=.822)
APBB2	ENSP00000318965³	STRING (score=.802)
ABCA1	ENSP00000363868³	STRING (score=.742)
BACE1	ENSP00000318585³	STRING (score=.714)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006707	cholesterol catabolic process	TAS	10377398
GO:0007399	nervous system development	TAS	10377398
GO:0008202	steroid metabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for CYP46A1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CYP46A1
3 Novoseek chemical compound relationships for CYP46A1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
24s-hydroxy-cholesterol	97.93	36	15975088 (5), 16321981 (3), 19286353 (2), 12232784 (2) (see all 18)
cholesterol	70.55	130	19286353 (4), 16321981 (4), 19317426 (4), 16734927 (4) (see all 37)
lathosterol	65.71	1	15975088 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP46A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP46A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006668

Sigma-Aldrich siRNA and siRNA Panels for CYP46A1

Sigma-Aldrich shRNA for CYP46A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006668

REFSEQ mRNAs for CYP46A1 gene:

NM_006668.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006668

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006668
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006668
                                 untagged cDNA clone in CMV expression vector: NM_006668

Additional cDNA sequence:

AB209749.1 AF094480.1 AK090886.1 AK295216.1 BC022539.1 BC128037.1

3 DOTS entries:

DT.108005 DT.120794727 DT.97821898

24/31 AceView cDNA sequences (see all 31 ):

NM_006668 BU070694 CD623075 AF094480 BC022539 H06539 CD623079 BU741551

AI554732 BM727874 CD623081 BI552024 AW469811 AA961615 BQ066937 AK090886

BM805680 BU070933 BG704256 CF456253 BM548130 AA760981 CD623072 BF930893

highest scoring ESTs for CYP46A1:

AA961615 AF094480 AK090886 BC022539 BF930893 BM805680 H51951 AA760981 AI554732 AW469811

Unigene Cluster for CYP46A1:

Cytochrome P450, family 46, subfamily A, polypeptide 1

Hs.25121 [show with all ESTs]

Unigene Representative Sequence: AB209749

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP46A1

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15
SP1:											-
SP2:																											-

About this scheme

ECgene alternative splicing isoforms for CYP46A1

2 Ensembl transcripts including schematic representations:

ENST00000380228 ENST00000261835

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CYP46A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP46A1

¹ / ² / ³

3 probe-sets matching CYP46A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45429_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA961615	0.80	1.00	0.91	1
220331_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006668	0.60	1.00	0.82	1
220331_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CYP46A1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCCTTCCTG

SOURCE GeneReport for Unigene cluster: Hs.25121
UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2
Tissue specificity: Expressed in brain. The mRNA was broadly distributed with higher levels in gray
matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but
its expression increases linearly with age

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CYP46A1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC480432¹	--	similar to Cytochrome p450 46A1 (Cholesterol 24-hydroxylase)	90.25(n) 94.1(a)	480432 XM_537552.2 XP_537552.2
chimpanzee (Pan troglodytes)	CYP46A1¹	--	cytochrome P450, family 46, subfamily A, polypeptide more	99.42(n) 99.78(a)	453154 XM_510158.2 XP_510158.2
cow (Bos taurus)	CYP46A1¹	--	cytochrome P450, family 46, subfamily A, polypeptide more	90.33(n) 93(a)	506438 NM_001076810.1 NP_001070278.1
rat (Rattus norvegicus)	Cyp46a1¹	--	cytochrome P450, family 46, subfamily a, polypeptide more	89.73(n) 95(a)	362782 XM_343108.3 XP_343109.1
mouse (Mus musculus)	Cyp46a1^{1, 5}	12⁵	cytochrome P450, family 46, subfamily a, polypeptide more^{1, 5}	89.6(n)¹ 94.8(a)¹	13116¹ NM_010010.1¹ NP_034140.1¹ AF094479⁵ AK140740⁵ (see all 7)

About this table Species with no ortholog for CYP46A1

ENSEMBL Gene Tree for CYP46A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/250 NCBI SNPs in CYP46A1 are shown (see all 250 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 78)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4145039^1,2	A,C,F,H	99219255(-)	`TGGGGG/TTTGGA`	1	--	ng5¹		8		EU EA WA	840
	rs8003602^1,2	A,C,F	99218714(+)	`CCTCTC/TCAGAC`	1	--	ng5¹		4		NA EA	362
	rs3783320^1,2	A,C	99219211(+)	`CCCTAA/GCTATA`	1	--	ng5¹		0	--	--	--	--
--	rs8019753^1,2	A,C	99218651(+)	`ggattC/Tgctgt`	1	--	ng5¹		0	--	--	--	--
--	rs11850643^1,2	A	99263437(+)	`TGCTCA/GTCTGT`	1	--	ng3¹		0	--	--	--	--
	rs15506^1,2	F	99263312(-)	`TCACAC/TGCAGA`	1	--	ut3¹		2		MN	372
	rs8022722^1,2	A,C,F,H	99252478(+)	`TGGTAA/GTGCAG`	1	--	int¹		7		EU EA WA NA	552
	rs7157032^1,2	A,C,F,H	99254776(+)	`GCAAGG/TGTCAA`	1	--	int¹		15		EU EA WA NA	1328
	rs3752958^1,2	A,C,F,H	99252440(+)	`GAAGCC/ACCATC`	1	--	int¹		5		EA EU WA	1170
	rs8018381^1,2	A,C,F,H	99259883(+)	`CTTACA/TTTGTC`	1	--	int¹		8		EU EA WA	834

About this table

HapMap Linkage Disequilibrium images for CYP46A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604087

2 Novoseek disease relationships for CYP46A1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	71.51	40	19286353 (2), 15034781 (2), 15106838 (2), 15331159 (2) (see all 22)
senile plaques	40.76	6	15148325 (2), 15331159 (1)

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Human Gene Mutation Database: CYP46A1
Genetic Association Database: CYP46A1
Human Genome Epidemiology Navigator: CYP46A1 (28 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/58 PubMed articles for CYP46A1 gene (see all 58 ):

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. (PubMed id 10377398)^{1, 2, 3, 4} Lund E.G.... Russell D.W. (1999)
CYP46: a risk factor for Alzheimer's disease or a coincidence? (PubMed id 15936520)^{1, 3, 6} Golanska E....Liberski P.P. (2005)
Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease. (PubMed id 15034781)^{1, 3, 6} Johansson A....Prince J.A. (2004)
Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease. (PubMed id 15331159)^{1, 3, 6} Ingelsson M....Rebeck G.W. (2004)
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. (PubMed id 12533085)^{1, 3, 6} Papassotiropoulos A....Hock C. (2003)
The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins. (PubMed id 15975088)^{1, 3, 6} Vega G.L....Moore C. (2004)
Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators. (PubMed id 15165699)^{1, 3, 6} Borroni B....Padovani A. (2004)
Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease. (PubMed id 16055229)^{1, 3, 6} Tedde A....Sorbi S. (2006)
Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)^{1, 3, 6} Kabbara A....Lambert J.C. (2004)
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. (PubMed id 16157450)^{1, 3, 6} Shibata N.... Rogaeva E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10858	HGNC: 2641	AceView: CYP46A1	Ensembl:ENSG00000036530	euGenes: HUgn10858
ECgene: CYP46A1	H-InvDB: CYP46A1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for CYP46A1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CYP46A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CYP46A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CYP46A1		Antibodies for CYP46A1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CYP46A1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CYP46A1)
	Antibodies (CYP46A1)
	Chimera RNAi (CYP46A1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (CYP46)

Search OriGene for CYP46A1

Search Tocris compounds for CYP46A1

	Drugs for CYP46A1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CYP46A1

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CYP46A1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for CYP46A1

Summaries
for CYP46A1

Genomic Location
for CYP46A1

Proteins
for CYP46A1

Protein Domains/
Families
for CYP46A1

Gene Function
for CYP46A1

Pathways & Interactions
for CYP46A1

Drugs & Compounds
for CYP46A1

Transcripts
for CYP46A1

Expression
for CYP46A1

Orthologs
for CYP46A1

Paralogs
for CYP46A1

SNPs/Variants
for CYP46A1

Disorders & Mutations
for CYP46A1

Medical News
for CYP46A1

Publications
for CYP46A1

Search for CYP46A1

Genome Databases showing CYP46A1

Other Databases showing CYP46A1

Specialized Databases showing CYP46A1

Licensable Technologies
for CYP46A1

Services
for CYP46A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CYP46A1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor CYP46A1

Summariesfor CYP46A1

Genomic Locationfor CYP46A1

Proteinsfor CYP46A1

Protein Domains/Familiesfor CYP46A1

Gene Functionfor CYP46A1

Pathways & Interactionsfor CYP46A1

Drugs & Compoundsfor CYP46A1

Transcriptsfor CYP46A1

Expression for CYP46A1

Orthologsfor CYP46A1

Paralogsfor CYP46A1

SNPs/Variantsfor CYP46A1

Disorders & Mutationsfor CYP46A1

Medical Newsfor CYP46A1

Publicationsfor CYP46A1

Search for CYP46A1

Genome Databases showing CYP46A1

Other Databases showing CYP46A1

Specialized Databases showing CYP46A1

Licensable Technologiesfor CYP46A1

Servicesfor CYP46A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CYP46A1

Summaries
for CYP46A1

Genomic Location
for CYP46A1

Proteins
for CYP46A1

Protein Domains/
Families
for CYP46A1

Gene Function
for CYP46A1

Pathways & Interactions
for CYP46A1

Drugs & Compounds
for CYP46A1

Transcripts
for CYP46A1

Expression
for CYP46A1

Orthologs
for CYP46A1

Paralogs
for CYP46A1

SNPs/Variants
for CYP46A1

Disorders & Mutations
for CYP46A1

Medical News
for CYP46A1

Publications
for CYP46A1

Licensable Technologies
for CYP46A1

Services
for CYP46A1