CYP46A1 Gene
protein-coding GIFtS: 56
GCID: GC14P100150
|
|
cytochrome P450, family 46, subfamily A, polypeptide 1(Previous names: cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)...)
(Previous symbol: CYP46)
| |
Aliases
for CYP46A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 46, Subfamily A, Polypeptide 11 2 | | CH24H2 3 | | CYP461 2 3 5 | | CP462 | | Cytochrome P450, Subfamily 46 (Cholesterol 24-Hydroxylase)1 2 | | Cholesterol 24-Hydroxylase2 | | Cytochrome P450 46A12 3 | | EC 1.14.13.983 |
Export aliases for CYP46A1 gene to outside databasesPrevious GC identifers: GC14P093966 GC14P098140 GC14P099220 GC14P080333 |
Summaries
for CYP46A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP46A1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secretedin the brain into the circulation to be returned to the liver for catabolism. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2Function: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesserextent, 25-hydroxycholesterol
Gene Wiki entry for CYP46A1
|
Genomic Views
for CYP46A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP46A1 gene promoter:
AhR Tal-1beta Arnt PPAR-gamma1 CP2 FOXJ2 (long isoform) Chx10 PPAR-gamma2 FOXJ2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP46A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP46A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.1CYP46A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P100150: view genomic region
(about GC identifiers)
Start:
|
100,150,641 bp from pter |
End:
|
100,193,638 bp from pter |
Size:
|
42,998 bases |
Orientation:
|
plus strand |
|
Proteins
for CYP46A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2 (See
protein sequence)Recommended Name: Cholesterol 24-hydroxylase Size: 500 amino acids; 56821 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-passmembrane protein
6/8 PDB 3D structures from  and Proteopedia  for CYP46A1 (see all 8):2Q9F (3D)
2Q9G (3D)
3MDM (3D)
3MDR (3D)
3MDT (3D)
3MDV (3D)
Explore the universe of human proteins at neXtProt for CYP46A1: NX_Q9Y6A2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6A2
CYP46A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006659.1
ENSEMBL proteins: ENSP00000451069 ENSP00000261835 ENSP00000369577 ENSP00000450553 ENSP00000452151 ENSP00000451602 ENSP00000405779 Reactome Protein details: Q9Y6A2
Human Recombinant Protein Products for CYP46A1:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CYP46A1 for ontologies About GeneDecksing
CYP46A1 Antibody Products:
Assay Products for CYP46A1: |
Protein
Domains /
Families
for CYP46A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP46A1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y6A2ProtoNet protein and cluster: Q9Y6A2 UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2Similarity: Belongs to the cytochrome P450 family |
Function
for CYP46A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CP46A_HUMAN, Q9Y6A2Function: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesserextent, 25-hydroxycholesterolCatalytic activity: Cholesterol + NADPH + O(2) = (24S)-24-hydroxycholesterol + NADP(+) + H(2)OBiophysicochemical properties: Kinetic parameters: KM=2.2 uM for 24(S)-hydroxycholesterol; Enzyme Number (IUBMB): EC 1.14.13.981
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004497 | monooxygenase activity |
-- | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0008395 | steroid hydroxylase activity |
TAS | 10377398 | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
-- | -- |
CYP46A1 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Cyp46a1):
CYP46A1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP46A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP46A1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP46A1 (NM_006668) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP46A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP46A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP46A1 |
|
Pathways & Interactions
for CYP46A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of bile acids and bile salts | | | 2 | Cytochrome P450 - arranged by substrate type | | | 3 | Metabolism | | | 4 | Biological oxidations | | | 5 | Endogenous sterols | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for CYP46A1
5/9 
Reactome Pathways for CYP46A1 (see all 9)
1 
Kegg Pathway (Kegg details for CYP46A1):
CYP46A1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP46A1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for CYP46A1 (ENSP000002618354) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
CYP46A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP46A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP46A1 for compounds About GeneDecksing
 Browse Tocris compounds for CYP46A1
7 HMDB Compounds for CYP46A1 About this table
3 Novoseek chemical compound relationships for CYP46A1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CYP46A1 / CP46A
|
Transcripts
for CYP46A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP46A1 gene: NM_006668.1 Unigene Cluster for CYP46A1: Cytochrome P450, family 46, subfamily A, polypeptide 1 Hs.25121 [show with all ESTs]Unigene Representative Sequence: AB2097498 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000554611(uc001ygn.1) ENST00000261835(uc001ygo.3) ENST00000380228
ENST00000554176(uc001ygp.3) ENST00000554917 ENST00000556313 ENST00000556822
ENST00000423126
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP46A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP46A1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP46A1 (NM_006668) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP46A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP46A1 |
Additional cDNA sequence: AB209749.1 AF094480.1 AK090886.1 AK295216.1 BC022539.1 BC128037.1 3 DOTS entries: DT.108005 DT.120794727 DT.97821898 24/31 AceView cDNA sequences (see all 31): CD623075 NM_006668 BC022539 AF094480 BU070694 BQ066937 CD623079 AW469811 BU070933 AI554732 CD623081 H06539 BM727874 BI552024 BM805680 AA961615 AK090886 BU741551 BG704256 CF456253 AA760981 BM548130 BF930893 R49568
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP46A1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for CYP46A1
|
Expression
for CYP46A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP46A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTTCCTG
About this image
See CYP46A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP46A1
SOURCE GeneReport for Unigene cluster: Hs.25121
UniProtKB/Swiss-Prot: CP46A_HUMAN, Q9Y6A2Tissue specificity: Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones andlower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly withage
SABiosciences Expression via Pathway-Focused PCR Array including CYP46A1: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP46A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP46A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP46A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP46A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP46A1 |
Orthologs
for CYP46A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYP46A1 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for CYP46A1 (if available)
TreeFam Gene Tree for CYP46A1 (if available) |
Paralogs
for CYP46A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP46A1 gene
- CYP4F222 CYP4F32 CYP4F22 CYP4F112 ENSG000002256072 CYP4B12 CYP3A52 CYP4X12
- TBXAS12 CYP3A432 CYP3A42 CYP3A72 CYP4V22 CYP4A222 CYP4A112 CYP4F122
- CYP4Z12
3 SIMAP similar genes for CYP46A1 using alignment to 7 protein entries: CP46A_HUMAN (see all proteins):CYP3A43 CYP3A5 CYP4B1
CYP46A1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CYP46A1
PGOHUM00000261896
|
Genomic Variants
for CYP46A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP46A1 (100150641 - 100193638 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP46A1: --
Human Gene Mutation Database (HGMD): CYP46A1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP46A1 |
|
Disorders
/ Diseases
for CYP46A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP46A1 for disorders About GeneDecksing
OMIM gene information: 604087
OMIM disorders: --
16  diseases for CYP46A1: About MalaCardscholesterol open-angle glaucoma primary open angle glaucoma age related macular degeneration
cerebral amyloid angiopathy traumatic brain injury brain injury macular degeneration
glaucoma alzheimer's disease neurodegeneration cerebritis
dementia tuberculosis hepatitis mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for CYP46A1:Keratoconus 3 Novoseek disease relationships for CYP46A1 gene About this table
Genetic Association Database (GAD): CYP46A1
Human Genome Epidemiology (HuGE) Navigator: CYP46A1 (34 documents)
Export disorders for CYP46A1 gene to outside databases
|
Publications
for CYP46A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP46A1 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with CYP46A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. (PubMed id 10377398)1, 2, 3, 9 Lund E.G.... Russell D.W. (1999)
- CYP46: a risk factor for Alzheimer's disease or a coincidence? (PubMed id 15936520)1, 4, 9 Golanska E....Liberski P.P. (2005)
- Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease. (PubMed id 15034781)1, 4, 9 Johansson A....Prince J.A. (2004)
- Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease. (PubMed id 15331159)1, 4, 9 Ingelsson M....Rebeck G.W. (2004)
- Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. (PubMed id 12533085)1, 4, 9 Papassotiropoulos A....Hock C. (2003)
- Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators. (PubMed id 15165699)1, 4, 9 Borroni B....Padovani A. (2004)
- The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins. (PubMed id 15975088)1, 4, 9 Vega G.L....Moore C. (2004)
- Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease. (PubMed id 16055229)1, 4, 9 Tedde A....Sorbi S. (2006)
- Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)1, 4, 9 Kabbara A....Lambert J.C. (2004)
- Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. (PubMed id 16157450)1, 4, 9 Shibata N.... Rogaeva E. (2006)
|
External Searches for CYP46A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP46A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP46A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP46A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP46A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYP46A1 gene:
Search GeneIP for patents involving CYP46A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP46A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CYP46A1 | | OriGene shRNA RFP for CYP46A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP46A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP46A1 | | | OriGene Protein Over-expression Lysate for CYP46A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP46A1 | | OriGene 3'-UTR Clone for CYP46A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP46A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP46A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CYP46A1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP46A1 | | OriGene Custom Protein Services for CYP46A1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP46A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP46A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP46A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP46A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP46A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP46A1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CYP46A1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CYP46A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP46A1 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP46A1 |
| |  | |
|
|
|
