CYP3AP1 Gene
pseudogene GIFtS: 11
GCID: GC07M099283
|
|
CYP3AP1
| |
Aliases
for CYP3AP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CYP3A5P12 | | Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 Pseudogene 12 |
| External Ids: | Entrez Gene: 15782 |
|---|
Export aliases for CYP3AP1 gene to outside databases |
Summaries
for CYP3AP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP3AP1:
This locus represents a CYP3A pseudogene that is present within a cluster of CYP3A (cytochrome P450, family 3,subfamily A) genes on chromosome 7. This pseudogene is located between the CYP3A7 and CYP3A5 family members. Itcontains duplicates of exons 1, 2 and 13 that are found in the functional genes. Readthrough transcription existsbetween the CYP3A7 gene and this pseudogene, where the readthrough transcript includes CYP3A7 exons 1-13 and exons 2and 13 of this pseudogene, as represented in GeneID:100861540. This pseudogene is not known to be independentlytranscribed. (provided by RefSeq, Feb 2012)
|
Genomic Views
for CYP3AP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CYP3AP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP3AP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3AP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 CYP3AP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M099283: view genomic region
(about GC identifiers)
Start:
|
99,282,647 bp from pter |
End:
|
99,297,743 bp from pter |
Size:
|
15,097 bases |
Orientation:
|
minus strand |
CYP3AP1 has overlapping exons with:
|
CYP3AP2 |
1 alternative location:
| Chr7-,CRA_TCAG 98,642,455-98,657,555 |
|
Proteins
for CYP3AP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for CYP3AP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for CYP3AP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for CYP3AP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP3AP1
|
Drugs & Compounds
for CYP3AP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYP3AP1
Search CenterWatch for drugs/clinical trials and news about CYP3AP1 
|
Transcripts
for CYP3AP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 AceView cDNA sequence: BV181635
GeneLoc Exon Structure
|
Expression
for CYP3AP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for CYP3AP1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CYP3AP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3AP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3AP1 |
Orthologs
for CYP3AP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
|
Paralogs
for CYP3AP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CYP3AP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP3AP1 (99282647 - 99297743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP3AP1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CYP3AP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP3AP1 for disorders About GeneDecksing
1  disease for CYP3AP1: About MalaCardslung cancer
Export disorders for CYP3AP1 gene to outside databases
|
Publications
for CYP3AP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP3AP1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CYP3AP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. (PubMed id 15937338)1, 9 Rodriguez-Antona C....Ingelman-Sundberg M. (2005)
- CYP3AP1*3 Allele Is Associated With Lipid-Lowering Ef ficacy of Simvastatin and Atorvastatin in Chinese Women. (PubMed id 20519697)1 Li Y.P....Hu X.J. (2010)
- Pharmacogenetic analysis of lipid responses to rosuva statin in Chinese patients. (PubMed id 20679960)1 Hu M....Tomlinson B. (2010)
- Tacrolimus concentrations in relation to CYP3A and ABCB1 polymorphisms among solid organ transplant recipients in Korea. (PubMed id 19384171)1 Jun K.R....Min W.K. (2009)
- CYP450 polymorphisms predict clinic outcomes to vinorelbine-based chemotherapy in patients with non-small-cell lung cancer. (PubMed id 17450472)1 Pan J.H....Huang H.N. (2007)
- Sequence diversity and haplotype structure at the human CYP3A cluster. (PubMed id 16314882)1 Thompson E.E....Di Rienzo A. (2006)
- Genotype of CYP3AP1 associated with CYP3A activity in Chinese Han population. (PubMed id 12060534)1 Zhu B....Zhou H.H. (2002)
- The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. (PubMed id 11137287)1 Finta C. and Zaphiropoulos P.G. (2000)
- Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. (PubMed id 8569713)1 Schuetz J.D....Sun D. (1996)
- Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene. (PubMed id 7893755)1 Schuetz J.D. and Guzelian P.S. (1995)
|
External Searches for CYP3AP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP3AP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP3AP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP3AP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP3AP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYP3AP1 gene:
Search GeneIP for patents involving CYP3AP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP3AP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP3AP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP3AP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3AP1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP3AP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3AP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3AP1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CYP3AP1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for CYP3AP1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CYP3AP1 |
|
|
|
|
