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CYP3A7-CYP3AP1 Gene

protein-coding   GIFtS: 10
GCID: GC07U903224

CYP3A7-CYP3AP1 Readthrough


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CYP3A7-3AP12
CYP3A7.1L2
CYP3A7-CYP3AP1 Readthrough2

External Ids:    Entrez Gene: 1008615402   

Export aliases for CYP3A7-CYP3AP1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP3A7-CYP3AP1 Gene:
This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3,
subfamily A, polypeptide 7) and CYP3AP1 (cytochrome P450, family 3, subfamily A, pseudogene 1) genes, which are
members of the on CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently
transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It
encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T
nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the
upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents
the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript.
(provided by RefSeq, Feb 2012)

GeneCards Summary for CYP3A7-CYP3AP1 Gene:
CYP3A7-CYP3AP1 is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CYP3A7-CYP3AP1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A7-CYP3AP1


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q   

GeneLoc information about chromosome 7        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --
REFSEQ proteins: NP_001243426.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CYP3A7-CYP3AP1 About    
See pathways by source

SuperPathContained pathways About
1Cytochrome P450 - arranged by substrate type
cytochrome P4500.74
2Biological oxidations
metapathway biotransformation0.42


2 BioSystems Pathways for CYP3A7-CYP3AP1
    cytochrome P450
metapathway biotransformation


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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CYP3A7-CYP3AP1 gene: 
NM_001256497.1  

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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CYP3A7-CYP3AP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CYP3A7-CYP3AP1 Expression
About this image

CYP3A7-CYP3AP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7-CYP3AP1 gene from 4 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
rat
(Rattus norvegicus)
Mammalia Cyp3a621 cytochrome P450, family 3, subfamily a, polypeptide more 77.33(n)
69.82(a)
  170509  NM_001024232.1  NP_001019403.1 
fruit fly
(Drosophila melanogaster)
Insecta Cyp6a131 Cyp6a13 44.67(n)
34.66(a)
  35837  NM_136546.3  NP_610390.1 
worm
(Caenorhabditis elegans)
Secernentea cyp-13A81 cyp-13A8 49.36(n)
35.67(a)
  188358  NM_063714.1  NP_496115.1 
rice
(Oryza sativa)
Liliopsida Os07g06472001 Os07g0647200 42.48(n)
30.51(a)
  4344107  NM_001067002.1  NP_001060467.1 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CYP3A7-CYP3AP1 (see all 352)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1814311181,2
--99281851(+) GTAATA/GGTGCG 1 -- ds50010--------
rs616739301,2
C,F--99281855(+) TGGTGC/TGTCTC 1 -- ds500115Minor allele frequency- T:0.01MN WA EA 2714
rs1907175411,2
--99282136(+) ATGGGA/CAAAGT 1 -- ds50010--------
rs7767401,2
C,F,A,H--99282143(-) CACTGT/AGACTT 1 -- ds500113Minor allele frequency- A:0.10NS EA NA CSA WA 1451
rs766982701,2
C,F--99282219(+) TTACAA/GTGATC 1 -- ds50011Minor allele frequency- G:0.05WA 118
rs1479134991,2
--99282226(+) GATCAC/TATATA 1 -- ds50010--------
rs1819072491,2
--99282263(+) GTTCTA/GTAGAT 1 -- ds50010--------
rs1860399331,2
--99282435(+) GATGAA/CATTAT 1 -- ut310--------
rs1909555821,2
--99282494(+) TAACTA/CGGGGT 1 -- ut310--------
rs1831741601,2
--99282709(+) TCTCTA/GGTGTT 1 -- ut310--------
Structural Variations
      Database of Genomic Variants (DGV) variations for CYP3A7-CYP3AP1: --
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CYP3A7-CYP3AP1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CYP3A7-CYP3AP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. (PubMed id 15937338)1 Rodriguez-Antona C....Ingelman-Sundberg M. (J. Biol. Chem. 2005)
  2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1 Hillier L.W.... Wilson R.K. (Nature 2003)
  3. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. (PubMed id 11137287)1 Finta C. and Zaphiropoulos P.G. (Gene 2000)
  4. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100861540 euGenes: HUgn100861540

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CYP3A7-CYP3AP1 gene:
Search GeneIP for patents involving CYP3A7-CYP3AP1

GeneCards and IP:
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