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Aliases for CYP3A7-CYP3A51P Gene

Aliases for CYP3A7-CYP3A51P Gene

  • CYP3A7-CYP3A51P Readthrough 2 3
  • EC 1.14.14.1 4 64
  • CYP3A7-CYP3AP1 Readthrough 3
  • CYP3A7-CYP3A51P Protein 3
  • Cytochrome P450-HFLA 4
  • CYP3A7-CYP3AP1 3
  • CYP3A7-3AP1 3
  • CYP3A7.1L 3
  • CYPIIIA7 4
  • CYP3A7 4

External Ids for CYP3A7-CYP3A51P Gene

Summaries for CYP3A7-CYP3A51P Gene

Entrez Gene Summary for CYP3A7-CYP3A51P Gene

  • This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7-CYP3A51P Gene

CYP3A7-CYP3A51P (CYP3A7-CYP3A51P Readthrough) is a Protein Coding gene. Among its related pathways are Biological oxidations and Cytochrome P450 - arranged by substrate type. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7-CYP3A51P Gene

Genomics for CYP3A7-CYP3A51P Gene

Genomic Location for CYP3A7-CYP3A51P Gene

Start:
99,684,679 bp from pter
End:
99,735,196 bp from pter
Size:
50,518 bases
Orientation:
Minus strand

Genomic View for CYP3A7-CYP3A51P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP3A7-CYP3A51P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A7-CYP3A51P Gene

No data available for Regulatory Elements for CYP3A7-CYP3A51P Gene

Proteins for CYP3A7-CYP3A51P Gene

  • Protein details for CYP3A7-CYP3A51P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7-CYP3A51P Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7-CYP3A51P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7-CYP3A51P Gene

Proteomics data for CYP3A7-CYP3A51P Gene at MOPED

Protein Expression for CYP3A7-CYP3A51P Gene

Post-translational modifications for CYP3A7-CYP3A51P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A7-CYP3A51P Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP3A7-CYP3A51P Gene

UniProtKB/Swiss-Prot:

CP3A7_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • P24462
genes like me logo Genes that share domains with CYP3A7-CYP3A51P: view

No data available for Gene Families for CYP3A7-CYP3A51P Gene

Function for CYP3A7-CYP3A51P Gene

Molecular function for CYP3A7-CYP3A51P Gene

UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP3A7-CYP3A51P Gene

Gene Ontology (GO) - Molecular Function for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0019825 oxygen binding --
GO:0020037 heme binding --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP3A7-CYP3A51P Gene

Localization for CYP3A7-CYP3A51P Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

Pathways for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share pathways with CYP3A7-CYP3A51P: view

Pathways by source for CYP3A7-CYP3A51P Gene

2 BioSystems pathways for CYP3A7-CYP3A51P Gene

Interacting Proteins for CYP3A7-CYP3A51P Gene

Gene Ontology (GO) - Biological Process for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process --
GO:0044281 small molecule metabolic process --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

Transcripts for CYP3A7-CYP3A51P Gene

mRNA/cDNA for CYP3A7-CYP3A51P Gene

(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7-CYP3A51P Gene

No ASD Table

Relevant External Links for CYP3A7-CYP3A51P Gene

GeneLoc Exon Structure for
CYP3A7-CYP3A51P
ECgene alternative splicing isoforms for
CYP3A7-CYP3A51P

Expression for CYP3A7-CYP3A51P Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP3A7-CYP3A51P Gene

Orthologs for CYP3A7-CYP3A51P Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7-CYP3A51P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A67 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 73 (a)
ManyToMany
CYP3A5 37
  • 70 (a)
ManyToMany
CYP3A5 37
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 73 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
CYP3A12 37
  • 76 (a)
ManyToMany
CYP3A26 37
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 37
  • 70 (a)
ManyToMany
Cyp3a13 37
  • 72 (a)
ManyToMany
Cyp3a16 37
  • 68 (a)
ManyToMany
Cyp3a25 37
  • 67 (a)
ManyToMany
Cyp3a41a 37
  • 69 (a)
ManyToMany
Cyp3a41b 37
  • 69 (a)
ManyToMany
Cyp3a44 37
  • 67 (a)
ManyToMany
Cyp3a57 37
  • 66 (a)
ManyToMany
Cyp3a59 37
  • 65 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp3a62 36
  • 77.33 (n)
  • 69.82 (a)
chicken
(Gallus gallus)
Aves CYP3A37 37
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 37
  • 53 (a)
ManyToMany
cyp3c1 37
  • 48 (a)
ManyToMany
cyp3c1l2 37
  • 49 (a)
ManyToMany
cyp3c4 37
  • 48 (a)
ManyToMany
si:dkey-21n8.3 37
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp6a13 36
  • 44.67 (n)
  • 34.66 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-13A8 36
  • 49.36 (n)
  • 35.67 (a)
rice
(Oryza sativa)
Liliopsida Os07g0647200 36
  • 42.48 (n)
  • 30.51 (a)
Species with no ortholog for CYP3A7-CYP3A51P:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP3A7-CYP3A51P Gene

ENSEMBL:
Gene Tree for CYP3A7-CYP3A51P (if available)
TreeFam:
Gene Tree for CYP3A7-CYP3A51P (if available)

Paralogs for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share paralogs with CYP3A7-CYP3A51P: view

Variants for CYP3A7-CYP3A51P Gene

Sequence variations from dbSNP and Humsavar for CYP3A7-CYP3A51P Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs776739 -- 99,686,073(-) ctcac(A/G)ctggg intron-variant
rs776740 -- 99,684,520(-) CACTG(A/T)GACTT downstream-variant-500B
rs776742 -- 99,695,132(-) TCAGA(A/G)CAAAG intron-variant
rs776743 -- 99,694,964(-) CATAT(A/G)CAAAA intron-variant
rs776744 -- 99,694,424(-) TCCAT(A/G)TTAAG intron-variant

Relevant External Links for CYP3A7-CYP3A51P Gene

HapMap Linkage Disequilibrium report
CYP3A7-CYP3A51P

No data available for Structural Variations from Database of Genomic Variants (DGV) for CYP3A7-CYP3A51P Gene

Disorders for CYP3A7-CYP3A51P Gene

No disorders were found for CYP3A7-CYP3A51P Gene.

No data available for UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

Publications for CYP3A7-CYP3A51P Gene

  1. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. (PMID: 11137287) Finta C. … Zaphiropoulos P.G. (Gene 2000) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3
  3. A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. (PMID: 15937338) Rodriguez-Antona C. … Ingelman-Sundberg M. (J. Biol. Chem. 2005) 3
  4. Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family. (PMID: 2492179) Wrighton S.A. … Vandenbranden M. (Arch. Biochem. Biophys. 1989) 4
  5. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PMID: 2722762) Komori M. … Kamataki T. (J. Biochem. 1989) 4

Products for CYP3A7-CYP3A51P Gene

Sources for CYP3A7-CYP3A51P Gene

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