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Aliases for CYP3A7-CYP3A51P Gene

Aliases for CYP3A7-CYP3A51P Gene

  • CYP3A7-CYP3A51P Readthrough 2 3 5
  • EC 1.14.14.1 4 63
  • CYP3A7-CYP3AP1 Readthrough 3
  • Cytochrome P450-HFLA 4
  • CYP3A7-CYP3AP1 3
  • CYP3A7-3AP1 3
  • CYP3A7.1L 3
  • CYPIIIA7 4
  • CYP3A7 4

External Ids for CYP3A7-CYP3A51P Gene

Summaries for CYP3A7-CYP3A51P Gene

Entrez Gene Summary for CYP3A7-CYP3A51P Gene

  • This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7-CYP3A51P Gene

CYP3A7-CYP3A51P (CYP3A7-CYP3A51P Readthrough) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7-CYP3A51P Gene

Genomics for CYP3A7-CYP3A51P Gene

Genomic Location for CYP3A7-CYP3A51P Gene

Chromosome:
7
Start:
99,684,679 bp from pter
End:
99,735,200 bp from pter
Size:
50,522 bases
Orientation:
Minus strand

Genomic View for CYP3A7-CYP3A51P Gene

Genes around CYP3A7-CYP3A51P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A7-CYP3A51P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A7-CYP3A51P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A7-CYP3A51P Gene

No data available for Regulatory Elements for CYP3A7-CYP3A51P Gene

Proteins for CYP3A7-CYP3A51P Gene

  • Protein details for CYP3A7-CYP3A51P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7-CYP3A51P Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7-CYP3A51P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7-CYP3A51P Gene

Proteomics data for CYP3A7-CYP3A51P Gene at MOPED

Protein Expression for CYP3A7-CYP3A51P Gene

Post-translational modifications for CYP3A7-CYP3A51P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A7-CYP3A51P Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP3A7-CYP3A51P Gene

Graphical View of Domain Structure for InterPro Entry

P24462

UniProtKB/Swiss-Prot:

CP3A7_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A7-CYP3A51P: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CYP3A7-CYP3A51P Gene

Function for CYP3A7-CYP3A51P Gene

Molecular function for CYP3A7-CYP3A51P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A7-CYP3A51P Gene

Gene Ontology (GO) - Molecular Function for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019825 oxygen binding TAS --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

Phenotypes for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share phenotypes with CYP3A7-CYP3A51P: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A7-CYP3A51P Gene

Localization for CYP3A7-CYP3A51P Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CYP3A7-CYP3A51P Gene

Pathways & Interactions for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share pathways with CYP3A7-CYP3A51P: view

Pathways by source for CYP3A7-CYP3A51P Gene

Interacting Proteins for CYP3A7-CYP3A51P Gene

Gene Ontology (GO) - Biological Process for CYP3A7-CYP3A51P Gene

None

No data available for SIGNOR curated interactions for CYP3A7-CYP3A51P Gene

Drugs & Compounds for CYP3A7-CYP3A51P Gene

No Compound Related Data Available

Transcripts for CYP3A7-CYP3A51P Gene

mRNA/cDNA for CYP3A7-CYP3A51P Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7-CYP3A51P Gene

No ASD Table

Relevant External Links for CYP3A7-CYP3A51P Gene

GeneLoc Exon Structure for
CYP3A7-CYP3A51P
ECgene alternative splicing isoforms for
CYP3A7-CYP3A51P

Expression for CYP3A7-CYP3A51P Gene

Protein differential expression in normal tissues from HIPED for CYP3A7-CYP3A51P Gene

This gene is overexpressed in Fetal Liver (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP3A7-CYP3A51P Gene



Protein tissue co-expression partners for CYP3A7-CYP3A51P Gene

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYP3A7-CYP3A51P Gene

Orthologs for CYP3A7-CYP3A51P Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7-CYP3A51P Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Cyp3a62 35
  • 77.33 (n)
  • 69.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp6a13 35
  • 44.67 (n)
  • 34.66 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-13A8 35
  • 49.36 (n)
  • 35.67 (a)
rice
(Oryza sativa)
Liliopsida Os07g0647200 35
  • 42.48 (n)
  • 30.51 (a)
Species with no ortholog for CYP3A7-CYP3A51P:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP3A7-CYP3A51P Gene

ENSEMBL:
Gene Tree for CYP3A7-CYP3A51P (if available)
TreeFam:
Gene Tree for CYP3A7-CYP3A51P (if available)

Paralogs for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share paralogs with CYP3A7-CYP3A51P: view

Variants for CYP3A7-CYP3A51P Gene

Relevant External Links for CYP3A7-CYP3A51P Gene

HapMap Linkage Disequilibrium report
CYP3A7-CYP3A51P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CYP3A7-CYP3A51P Gene

Disorders for CYP3A7-CYP3A51P Gene

Relevant External Links for CYP3A7-CYP3A51P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A7-CYP3A51P

No disorders were found for CYP3A7-CYP3A51P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A7-CYP3A51P Gene

Publications for CYP3A7-CYP3A51P Gene

  1. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. (PMID: 11137287) Finta C. … Zaphiropoulos P.G. (Gene 2000) 3 4 67
  2. A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. (PMID: 15937338) Rodriguez-Antona C. … Ingelman-Sundberg M. (J. Biol. Chem. 2005) 3
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3
  4. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3
  5. Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region. (PMID: 1562592) Itoh S. … Kamataki T. (Biochim. Biophys. Acta 1992) 3

Products for CYP3A7-CYP3A51P Gene

Sources for CYP3A7-CYP3A51P Gene

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