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Aliases for CYP3A7-CYP3A51P Gene

Aliases for CYP3A7-CYP3A51P Gene

  • CYP3A7-CYP3A51P Readthrough 2 3 5
  • EC 1.14.14.1 4 61
  • CYP3A7-CYP3AP1 Readthrough 3
  • CYP3A7-CYP3A51P Protein 3
  • Cytochrome P450-HFLA 4
  • CYP3A7-CYP3AP1 3
  • CYP3A7-3AP1 3
  • CYP3A7.1L 3
  • CYPIIIA7 4
  • CYP3A7 4

External Ids for CYP3A7-CYP3A51P Gene

Summaries for CYP3A7-CYP3A51P Gene

Entrez Gene Summary for CYP3A7-CYP3A51P Gene

  • This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7-CYP3A51P Gene

CYP3A7-CYP3A51P (CYP3A7-CYP3A51P Readthrough) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP3A7.

UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7-CYP3A51P Gene

Genomics for CYP3A7-CYP3A51P Gene

Regulatory Elements for CYP3A7-CYP3A51P Gene

Enhancers for CYP3A7-CYP3A51P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G099728 1.4 ENCODE dbSUPER 0.4 +5.5 5547 3.1 FOXA2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 ZSCAN25 TRRAP GIGYF1 LOC100419643 STAG3L5P LOC101927550 ZNF655 ENSG00000242798 MEPCE PPP1R35
GH07G099737 0.8 ENCODE dbSUPER 0.7 -2.7 -2736 1.1 ZNF680 ZNF600 PRDM1 ZNF518A CYP3A5 CYP3A7-CYP3A51P CYP3A7 CYP3AP2
GH07G099750 1.3 Ensembl ENCODE dbSUPER 0.4 -16.9 -16900 2.3 PKNOX1 KLF17 ZNF121 ZNF366 FOS ZEB2 ZNF398 SMARCA4 PBX2 ZNF341 CYP3A5 CYP3AP2 CYP3A7-CYP3A51P CYP3A7
GH07G099742 1.1 ENCODE dbSUPER 0.4 -7.6 -7623 0.1 ELF3 FOXA2 ARID4B THRB RAD21 RARA YY1 ZNF121 CREM MIXL1 CYP3A7 CYP3A7-CYP3A51P CYP3AP2
GH07G099740 0.8 ENCODE 0.4 -5.7 -5684 1.7 ESRRA ZNF175 ZMYM3 MAX CEBPG RAD21 ZNF584 TRIM24 ZNF263 GATAD2A ZSCAN25 CYP3A7-CYP3A51P CYP3A7 CYP3AP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP3A7-CYP3A51P on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP3A7-CYP3A51P Gene

Chromosome:
7
Start:
99,684,679 bp from pter
End:
99,735,200 bp from pter
Size:
50,522 bases
Orientation:
Minus strand

Genomic View for CYP3A7-CYP3A51P Gene

Genes around CYP3A7-CYP3A51P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A7-CYP3A51P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A7-CYP3A51P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A7-CYP3A51P Gene

Proteins for CYP3A7-CYP3A51P Gene

  • Protein details for CYP3A7-CYP3A51P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7-CYP3A51P Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7-CYP3A51P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7-CYP3A51P Gene

Protein Expression for CYP3A7-CYP3A51P Gene

Selected DME Specific Peptides for CYP3A7-CYP3A51P Gene

P24462:
  • LAVETWLLLAV
  • VLVKECYSVFTN
  • PGPTPLP
  • LSFIIYEL
  • PCKETQIPLK
  • EEWKRIR
  • SVFTNRR
  • PNKAPPTYD
  • RVDFLQLM
  • ALVRVLQNF
  • LLSPTFT
  • LSPTFTSG
  • PTFTSGK
  • NIDPYIY
  • DFLQLMIDSQ
  • KVQKEID
  • PERFSKKN

Post-translational modifications for CYP3A7-CYP3A51P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A7-CYP3A51P Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP3A7-CYP3A51P Gene

Graphical View of Domain Structure for InterPro Entry

P24462

UniProtKB/Swiss-Prot:

CP3A7_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A7-CYP3A51P: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CYP3A7-CYP3A51P Gene

Function for CYP3A7-CYP3A51P Gene

Molecular function for CYP3A7-CYP3A51P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A7-CYP3A51P Gene

Gene Ontology (GO) - Molecular Function for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0008395 steroid hydroxylase activity IDA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

Phenotypes for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share phenotypes with CYP3A7-CYP3A51P: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A7-CYP3A51P Gene

Localization for CYP3A7-CYP3A51P Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7-CYP3A51P Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

No data available for Subcellular locations from COMPARTMENTS for CYP3A7-CYP3A51P Gene

Pathways & Interactions for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share pathways with CYP3A7-CYP3A51P: view

Interacting Proteins for CYP3A7-CYP3A51P Gene

Selected Interacting proteins: P24462-CP3A7_HUMAN for CYP3A7-CYP3A51P Gene via IID

Gene Ontology (GO) - Biological Process for CYP3A7-CYP3A51P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP3A7-CYP3A51P: view

No data available for SIGNOR curated interactions for CYP3A7-CYP3A51P Gene

Transcripts for CYP3A7-CYP3A51P Gene

mRNA/cDNA for CYP3A7-CYP3A51P Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7-CYP3A51P Gene

No ASD Table

Relevant External Links for CYP3A7-CYP3A51P Gene

GeneLoc Exon Structure for
CYP3A7-CYP3A51P
ECgene alternative splicing isoforms for
CYP3A7-CYP3A51P

Expression for CYP3A7-CYP3A51P Gene

Protein differential expression in normal tissues from HIPED for CYP3A7-CYP3A51P Gene

This gene is overexpressed in Fetal Liver (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP3A7-CYP3A51P Gene



Protein tissue co-expression partners for CYP3A7-CYP3A51P Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A7-CYP3A51P Gene

Orthologs for CYP3A7-CYP3A51P Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7-CYP3A51P Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Cyp3a62 34
  • 77.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cyp6a13 34
  • 44.67 (n)
worm
(Caenorhabditis elegans)
Secernentea cyp-13A8 34
  • 49.36 (n)
rice
(Oryza sativa)
Liliopsida Os07g0647200 34
  • 42.48 (n)
Species where no ortholog for CYP3A7-CYP3A51P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP3A7-CYP3A51P Gene

ENSEMBL:
Gene Tree for CYP3A7-CYP3A51P (if available)
TreeFam:
Gene Tree for CYP3A7-CYP3A51P (if available)

Paralogs for CYP3A7-CYP3A51P Gene

genes like me logo Genes that share paralogs with CYP3A7-CYP3A51P: view

Variants for CYP3A7-CYP3A51P Gene

Sequence variations from dbSNP and Humsavar for CYP3A7-CYP3A51P Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000189515 -- 99,723,701(+) CACCA(A/T)TTTTA intron-variant, nc-transcript-variant
rs1000192281 -- 99,698,266(+) GACCG(C/G)CCCAC intron-variant
rs1000240401 -- 99,686,821(+) CAGAG(A/G)AACGA intron-variant
rs1000318792 -- 99,735,367(+) TAATA(C/T)TCTAT intron-variant, upstream-variant-2KB
rs1000335541 -- 99,691,751(+) AGTAG(A/G)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A7-CYP3A51P Gene

Variant ID Type Subtype PubMed ID
esv2734887 CNV deletion 23290073
esv29839 CNV loss 19812545
esv8941 CNV gain 19470904
nsv522107 CNV loss 19592680
nsv5865 CNV insertion 18451855
nsv970911 CNV duplication 23825009

Relevant External Links for CYP3A7-CYP3A51P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A7-CYP3A51P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CYP3A7-CYP3A51P Gene

Disorders for CYP3A7-CYP3A51P Gene

Relevant External Links for CYP3A7-CYP3A51P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A7-CYP3A51P

No disorders were found for CYP3A7-CYP3A51P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A7-CYP3A51P Gene

Publications for CYP3A7-CYP3A51P Gene

  1. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. (PMID: 11137287) Finta C. … Zaphiropoulos P.G. (Gene 2000) 3 4 64
  2. A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. (PMID: 15937338) Rodriguez-Antona C. … Ingelman-Sundberg M. (J. Biol. Chem. 2005) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4 64

Products for CYP3A7-CYP3A51P Gene

Sources for CYP3A7-CYP3A51P Gene

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