CYP3A7 Gene

Aliases &
Descriptions
for CYP3A7 gene

Previous GC identifers: GC07M097828 GC07M098890 GC07M098904 GC07M098938 GC07M099135 GC07M099123

Summaries
for CYP3A7 gene

Genomic Views
for CYP3A7 gene

CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099293:  view genomic region     (about GC identifiers)

Proteins
for CYP3A7 gene

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and AQUA Peptides for CYP3A7
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CYP3A7
	HuPro® and/or Recombinant Proteins from Abnova for CYP3A7
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for CYP3A7
	Browse Sino Biological Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CYP3A7
	Browse R&D Systems for Antibodies
	Monoclonal and Polyclonal Antibodies from Abnova (CYP3A7)
	Browse Origene Antibodies
	Novus Biologicals Antibodies for CYP3A7
	Browse antibodies at Epitomics

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for CYP3A7

Protein Domains/
Families
for CYP3A7 gene

ProtoNet protein and cluster: P24462

Gene Function
for CYP3A7 gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP3A7)
		Origene 29mer shRNA kits in GFP-retroviral vector: CYP3A7 Origene shRNA RFP: CYP3A7 Origene basic RS shRNA: CYP3A7
		Applied Biosystems Silencer® siRNAs for CYP3A7
		Sigma-Aldrich siRNA Panels and siRNA for CYP3A7 Sigma-Aldrich shRNA for CYP3A7 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: CYP3A7 Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP3A7 Origene untagged cDNA clones in CMV expression vector: CYP3A7
		Browse Sino Biological Human cDNA Clones

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

Animal Models: 3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cyp3a13):

Pathways & Interactions
for CYP3A7 gene

2 Millipore Pathways for CYP3A7

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Retinol metabolism

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for  CYP3A7  (Your Favorite Gene powered by Ingenuity)

	Arachidonic Acid Metabolism
	Xenobiotic Metabolism Signaling
	Tryptophan Metabolism
	LPS/IL-1 Mediated Inhibition of RXR Function
	PXR/RXR Activation

5/7 Kegg Pathways  (Kegg details for CYP3A7)

	hsa00140 Steroid hormone biosynthesis
	hsa00591 Linoleic acid metabolism
	hsa00830 Retinol metabolism
	hsa00980 Metabolism of xenobiotics by cytochrome P450
	hsa00982 Drug metabolism - cytochrome P450

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

Drugs & Compounds
for CYP3A7 gene

Transcripts
for CYP3A7 gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP3A7)
		Applied Biosystems Silencer® siRNAs:  NM_000765
		Origene 29mer shRNA kits in GFP-retroviral vector: CYP3A7 Origene shRNA RFP: CYP3A7 Origene basic RS shRNA: CYP3A7
		Sigma-Aldrich siRNA Panels and siRNA for CYP3A7 Sigma-Aldrich shRNA for CYP3A7 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate CYP3A7:

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: CYP3A7 Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP3A7 Origene untagged cDNA clones in CMV expression vector: CYP3A7

Primers:		Origene genome-wide validated SYBR primer pairs: CYP3A7
		SABiosciences RT2 qPCR Primer Assay for CYP3A7: PPH01234A

REFSEQ mRNAs for CYP3A7 gene: 

24/85 AceView cDNA sequences (see all 85 ):

highest scoring ESTs for CYP3A7:

Expression
for CYP3A7 gene

CYP3A7 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CYP3A7

¹  / ²  / ³

8 probe-sets matching CYP3A7 gene

Expression variation in blood from EXPOLDB for CYP3A7

Primers:		Origene genome-wide validated SYBR primer pairs: CYP3A7
		SABiosciences RT2 qPCR Primer Assay for CYP3A7: PPH01234A

Orthologs
for CYP3A7 gene

Paralogs
for CYP3A7 gene

Paralogs for CYP3A7 gene

CYP4F22²  CYP4F11²  CYP4F2²  CYP4F3²  CYP4F8²  CYP46A1²  LOC388514²  CYP4B1²  

CYP3A5²  CYP4X1²  TBXAS1²  CYP3A43²  CYP3A4²  CYP4V2²  CYP4A22²  CYP4A11²  

CYP4Z1²  CYP4F12²  

CYP3A7 for paralogs           About GeneDecksing

Genomic Variants
for CYP3A7 gene

Disorders & Mutations
for CYP3A7 gene

6 Novoseek disease relationships for CYP3A7 gene

Medical News
for CYP3A7 gene

Publications
for CYP3A7 gene

• Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PubMed id 2722762)^{2, 3, 4} Komori M.... Kamataki T. (1989)
• A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PubMed id 15985487)^{1, 3, 6} Smit P....Lamberts S.W. (2005)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
• Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
• Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PubMed id 11266076)^{3, 4} Gellner K....Wojnowski L. (2001)
• Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family. (PubMed id 2492179)^{3, 4} Wrighton S.A. and Vandenbranden M. (1989)
• Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers. (PubMed id 2786707)^{3, 4} Komori M.... Kamataki T. (1989)
• CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele. (PubMed id 16041241)^{1, 3} Sim S.C....Ingelman-Sundberg M. (2005)
• Identification of a null allele of cytochrome P450 3A 7: CYP3A7 polymorphism in a Korean population. (PubMed id 19585271)^{1, 3} Lee S.S....Shin J.G. (year=2010;month=Jan;day=)
• Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine. (PubMed id 11940601)^{1, 3} Burk O....Wojnowski L. (2002)
• Association of CYP3A7*1C and Serum Dehydroepiandrosterone Sulfate Levels in Women with Polycystic Ovary Syndrome. (PubMed id 18445661)^{1, 3} Goodarzi M.O....Azziz R. (2008)
• A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. (PubMed id 15937338)^{1, 3} Rodriguez-Antona C....Ingelman-Sundberg M. (2005)
• Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PubMed id 17559345)^{1, 3} Du J....He L. (2007)
• Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle. (PubMed id 12485945)^{1, 3} Sarkar M.A....Glover D.D. (2003)
• Catalysis of the 4-hydroxylation of retinoic acids by cyp3a7 in human fetal hepatic tissues. (PubMed id 10950848)^{1, 3} Chen H....Juchau M.R. (2000)
• CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PubMed id 18978522)^{1, 3} Crettol S....Eap C.B. (2008)
• Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. (PubMed id 9644715)^{1, 3} Ohmori S....Kitada M. (1998)
• Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations. (PubMed id 17582393)³ Du J....He L. (2007)
• CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. (PubMed id 17334880)³ Bacsi K....Lakatos P. (2007)
• [Impact of CYP3A7*1C polymorphism on bone mineral content in postmenopausal women] (PubMed id 17604264)³ Bacsi K....Lakatos P. (2007)
• CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicula r cancer susceptibility. (PubMed id 20345875)³ Kristiansen W....Aschim E.L. (year=2010;month=Mar;day=19)
• Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450. (PubMed id 10708604)¹ Inoue E....Kamataki T. (2000)
• Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene. (PubMed id 15358113)¹ Hara H....Adachi T. (2004)
• Variability of CYP3A7 expression in human fetal liver. (PubMed id 15845858)¹ Leeder J.S....Pearce R.E. (2005)
• Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element. (PubMed id 11495920)¹ Saito T....Kamataki T. (2001)
• CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. (PubMed id 12642469)¹ Nakamura H....Kitada M. (2003)
• Identification of the fetal liver cytochrome CYP3A7 i n human endometrium and placenta. (PubMed id 08349787)¹ Schuetz J.D....Guzelian P.S. (year=1993;month=Aug;day=)
• Role of the liver-enriched transcription factors C/EB P alpha and DBP in the expression of human CYP3A4 and CYP3A7. (PubMed id 09204410)¹ Ourlin J.C....Vilarem M.J. (year=1997;month=;day=)
• Simultaneous expression of human CYP3A7 and N-acetylt ransferase in Chinese hamster CHL cells results in high cytotoxicity for carcin ogenic heterocyclic amines. (PubMed id 07625840)¹ Hashimoto H....Kamataki T. (year=1995;month=Jul;day=10)
• Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers. (PubMed id 15788369)¹ Yamaori S....Kamataki T. (2005)
• Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7. (PubMed id 14637191)¹ Yamaori S....Kamataki T. (2003)
• No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins. (PubMed id 10086328)¹ Tateishi T....Kobayashi S. (1999)
• Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. (PubMed id 10403778)¹ Pascussi J.M....Vilarem M.J. (1999)
• The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture. (PubMed id 8753820)¹ Greuet J....Maurel P. (1996)
• Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells. (PubMed id 15618651)¹ Ogino M....Yamazoe Y. (2002)
• Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. (PubMed id 7811260)¹ Jounaidi Y.... Vilarem M.J. (1994)
• In vivo activation of aflatoxin B1 in C57BL/6N mice c arrying a human fetus-specific CYP3A7 gene. (PubMed id 9044840)¹ Li Y....Kamataki T. (year=1997;month=Feb;day=15)
• In vivo activation of aflatoxin B1 in C57BL/6N mice c arrying a human fetus-specific CYP3A7 gene. (PubMed id 09044840)¹ Li Y....Kamataki T. (1997)
• In vivo detection of mutations induced by aflatoxin B1 using human CYP3A7/HITEC hybrid mice. (PubMed id 9735348)¹ Yamada A....Kamataki T. (1998)
• Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. (PubMed id 9266706)¹ Lacroix D....Cresteil T. (1997)
• Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7. (PubMed id 9204410)¹ Ourlin J.C....Vilarem M.J. (1997)
• Establishment of transgenic mice carrying human fetus-specific CYP3A7. (PubMed id 8638957)¹ Li Y....Kamataki T. (1996)
• Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines. (PubMed id 7625840)¹ Hashimoto H....Kamataki T. (1995)
• Efficient complementary DNA directed expression of human fetal liver cytochrome P450 (CYP3A7) in insect cells using baculovirus. (PubMed id 7663401)¹ Sakuma T....Kamataki T. (1995)

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