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CYP3A7 Gene

protein-coding   GIFtS: 65
GCID: GC07M099293

Cytochrome P450, Family 3, Subfamily A, Polypeptide 7

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 71 2     P450-HFLA2
Cytochrome P450, Subfamily IIIA, Polypeptide 71 2     Aryl Hydrocarbon Hydroxylase2
Cytochrome P450-HFLA2 3     Cytochrome P450 3A72
CYPIIIA72 3     Flavoprotein-Linked Monooxygenase2
EC 1.14.14.13 8     Microsomal Monooxygenase2
CP372     Xenobiotic Monooxygenase2

External Ids:    HGNC: 26401   Entrez Gene: 15512   Ensembl: ENSG000001608707   OMIM: 6053405   UniProtKB: P244623   

Export aliases for CYP3A7 gene to outside databases

Previous GC identifers: GC07M097828 GC07M098890 GC07M098904 GC07M098938 GC07M099135 GC07M099123 GC07M093939


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP3A7 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved
in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This
gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described,
but it is not known whether these transcripts are normally produced. This gene undergoes readthrough
transcription with the downstream CYP3AP1 pseudogene, resulting in an isoform with a novel C-terminus, as
represented in GeneID:100861540. (provided by RefSeq, Feb 2012)

GeneCards Summary for CYP3A7 Gene:
CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP3A7 gene promoter:
         SRF   GR   SRF (504 AA)   Ik-3   GATA-1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP3A7 promoter sequence
   Search Chromatin IP Primers for CYP3A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21-q22.1

CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099293:  view genomic region     (about GC identifiers)

Start:
99,302,660 bp from pter      End:
99,332,819 bp from pter
Size:
30,160 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,662,471-98,692,639     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462 (See protein sequence)
Recommended Name: Cytochrome P450 3A7  
Size: 503 amino acids; 57526 Da
Cofactor: Heme group (By similarity)
Secondary accessions: A4D288

Explore the universe of human proteins at neXtProt for CYP3A7: NX_P24462

Explore proteomics data for CYP3A7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP3A7 (P24462) (see all 17)
     SVFTNRR  PGPTPLP  PTFTSGK  NIDPYIY 


    See CYP3A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000756.2  
    ENSEMBL proteins: 
     ENSP00000337450  
    Reactome Protein details: P24462

    CYP3A7 Human Recombinant Protein Products:

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    antibodies-online peptides for CYP3A7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A7
    CYP3 family

    4 InterPro protein domains:
     IPR008072 Cyt_P450_E_CYP3A
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002402 Cyt_P450_E_grp-II

    Graphical View of Domain Structure for InterPro Entry P24462

    ProtoNet protein and cluster: P24462

    3 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB002402 Group II E-class P450 signature
    IPB008072 CYP3A P450 family signature


    UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP3A7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP3A7_HUMAN, P24462
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including
    drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP3A7:
    cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ISS--
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0019825oxygen binding TAS2722762
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with CYP3A7           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYP3A7

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP3A7_HUMAN, P24462: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with CYP3A7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP3A7 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Phenytoin Pathway, Pharmacokinetics0.00
    metapathway biotransformation0.42
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    cytochrome P4500.74
    Phase 1 - Functionalization of compounds0.75
    Xenobiotics0.00
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    4Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.10.57
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with CYP3A7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CYP3A7
        Retinol metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    2 BioSystems Pathways for CYP3A7
        cytochrome P450
    metapathway biotransformation


    1 Reactome Pathway for CYP3A7
        Xenobiotics

    2 PharmGKB Pathways for CYP3A7
        Carbamazepine Pathway, Pharmacokinetics
    Phenytoin Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for CYP3A7):
        Steroid hormone biosynthesis
    Retinol metabolism
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP3A7: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP3A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP3A7 (ENSP000003374504) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    CYP26B1ENSP000000011464STRING: ENSP00000001146
    CYP26C1ENSP000002859494STRING: ENSP00000285949
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP3A7 (CP3A7)

    Selected HMDB Compounds for CYP3A7 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Selected DrugBank Compounds for CYP3A7 (see all 117)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MidazolamDea No. 2884 (see all 4)59467-70-8enzymesubstrate inhibitor8886602 8185679 19934256 11996015
    Aminophenazone4-Dimethylaminoantipyrine (see all 3)58-15-1enzymesubstrate19934256
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymeinhibitor19934256
    BuprenorphineBuprenophine (see all 3)52485-79-7enzymesubstrate19515014
    CarbamazepineCarbamezepine (see all 3)298-46-4enzymesubstrate19934256
    CilostazolCilostazole (see all 2)73963-72-1enzymesubstrate10702888
    Cimetidine-- 51481-61-9enzymeinhibitor19934256
    Cisapride-- 81098-60-4enzymesubstrate19934256
    ClotrimazoleChlotrimazole (see all 2)23593-75-1enzymeinducer19934256
    CodeineCodeine anhydrous (see all 6)76-57-3enzymesubstrate19934256

    Selected Novoseek inferred chemical compound relationships for CYP3A7 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    troleandomycin 70.9 5 10950848 (1), 9555064 (1)
    2-amino-3-methylimidazo(4,5-f)quinoline 68.7 2 2066864 (1), 7625840 (1)
    1-hydroxymidazolam 64.7 1 8185679 (1)
    dhea 63.4 10 9644715 (2), 10708604 (1), 9555064 (1), 16041241 (1) (see all 7)
    aflatoxin b1 62.5 12 2109655 (3), 2066864 (2), 8638957 (1), 1904422 (1) (see all 6)
    dehydroepiandrosterone sulfate 59.5 8 15985487 (3), 2066864 (1), 9555064 (1), 9644715 (1)
    midazolam 55.9 2 8185679 (2)
    rifampicin 55 12 12673034 (2), 8753820 (2), 17978482 (2), 12843640 (1) (see all 6)
    testosterone 45.3 2 9555064 (1), 9644715 (1)
    clotrimazole 39.3 2 12673034 (2)



    Find genes that share compounds with CYP3A7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP3A7 gene: 
    NM_000765.3  

    Unigene Cluster for CYP3A7:

    Cytochrome P450, family 3, subfamily A, polypeptide 7
    Hs.111944  [show with all ESTs]
    Unigene Representative Sequence: BX647143
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477357 ENST00000336374(uc003uru.3) ENST00000498080 ENST00000467776

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    Additional mRNA sequence: 

    BC067436.1 BC069780.1 BX647143.1 D00408.1 

    8 DOTS entries:

    DT.100775927  DT.101984982  DT.86855768  DT.100775926  DT.100643862  DT.448158  DT.97768778  DT.91749006 

    Selected AceView cDNA sequences (see all 85):

    BX445330 AL531737 BX113858 AI078007 BX503313 BX445329 N39045 D00408 
    AW299577 AA410229 BC067436 BC069780 AI114634 BI094120 AV694230 NM_000765 
    CK130234 BX647143 CD013971 CF271966 CK130235 CF271964 CK130233 AA460048 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP3A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTATATCT
    CYP3A7 Expression
    About this image


    CYP3A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 4 entries
             Mature Hepatocytes Liver Lobule
             Immature hepatocyte-like cells
             Human Hepatocyte (HH)   
     
     Spleen (Hematopoietic System)
    CYP3A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP3A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111944
        Pathway & Disease-focused RT2 Profiler PCR Array including CYP3A7: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP3A7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp3a131 cytochrome P450, family 3, subfamily a, polypeptide more 79.57(n)
    72.46(a)
      13113  NM_007819.4  NP_031845.1 
    chicken
    (Gallus gallus)
    Aves CYP3A71 cytochrome P450 A 37 64.4(n)
    59.08(a)
      414832  NM_001001751.2  NP_001001751.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    59(a)
    52(a)
    many ↔ many
    many ↔ many
    GL343591.1(16157-77793)
    GL343987.1(113184-127496)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004876651 cytochrome P450 3A9-like 62.63(n)
    59.88(a)
      100487665  XM_002933916.2  XP_002933962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp3a651 cytochrome P450, family 3, subfamily A, polypeptide more 60.61(n)
    56.53(a)
      553969  NM_001037438.1  NP_001032515.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02219001 Os02g0221900 39.7(n)
    27.74(a)
      4328761  NM_001052860.1  NP_001046325.1 


    ENSEMBL Gene Tree for CYP3A7 (if available)
    TreeFam Gene Tree for CYP3A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP3A7 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    10 SIMAP similar genes for CYP3A7 using alignment to 3 protein entries:     CP3A7_HUMAN (see all proteins):
    DKFZp686I18188    CYP3A43/CYP3A4    CYP3A4    CYP3A5    CYP3A43    thromboxane synthase
    CYP2C9    TBXAS1    CYP2G1P    CYP2E1

    Find genes that share paralogs with CYP3A7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP3A7 (see all 715)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs455776431,2
    C,F--98662313(-) GTTCAC/TGCCAT 1 -- ds50012Minor allele frequency- T:0.02--192
    rs1397904281,2
    C--99307397(+) ATATA-/TGTG  
            
    TGTGT
    1 -- int10--------
    rs1451021651,2
    C--99309404(+) AACAA-/AACAACAA 1 -- cds10--------
    rs341545221,2
    C--99317220(+) AAAAAA/-TATTA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs114036181,2
    C--99320650(+) AAAAAA/-CCTTC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1900851691,2
    --102606034(+) TTGGCC/TTCCCA 1 -- ds50010--------
    rs1457399591,2
    --102606247(+) GAGATC/TGAGAG 1 -- ds50010--------
    rs1828247541,2
    --102606306(+) TTAGCC/TGGGCG 1 -- ds50010--------
    rs1860886681,2
    --102606308(+) AGCCGA/GGCGTG 1 -- ds50010--------
    rs1907564121,2
    --102606388(+) GAGCTC/TGCAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CYP3A7 (99302660 - 99332819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CYP3A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734887CNV Deletion23290073
    nsv522107CNV Loss19592680
    esv29839CNV Loss19812545
    nsv888771CNV Loss21882294
    esv8941CNV Gain19470904

    The Human Cytochrome P450 Allele Nomenclature Database: CYP3A7 
    Human Gene Mutation Database (HGMD): CYP3A7
    Locus Specific Mutation Databases (LSDB): CYP3A7

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A7
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP3A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605340    OMIM disorders: --


    Find genes that share disorders with CYP3A7           About GenesLikeMe

    1 Novoseek inferred disease relationship for CYP3A7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 0 1 10403778 (1)

    Genetic Association Database (GAD): CYP3A7
    Human Genome Epidemiology (HuGE) Navigator: CYP3A7 (27 documents)

    Export disorders for CYP3A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP3A7 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with CYP3A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PubMed id 2722762)1, 2, 3 Komori M.... Kamataki T. (J. Biochem. 1989)
    2. Identification of a null allele of cytochrome P450 3A7: CYP3A7 polymorphism in a Korean population. (PubMed id 19585271)1, 4, 9 Lee S.S....Shin J.G. (Mol. Biol. Rep. 2010)
    3. Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PubMed id 17559345)1, 4, 9 Du J....He L. (Pharmacogenomics 2007)
    4. A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PubMed id 15985487)1, 4, 9 Smit P....Lamberts S.W. (J. Clin. Endocrinol. Metab. 2005)
    5. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PubMed id 18978522)1, 4, 9 Crettol S....Eap C.B. (Ther Drug Monit 2008)
    6. Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. (PubMed id 18445661)1, 4, 9 Goodarzi M.O....Azziz R. (J. Clin. Endocrinol. Metab. 2008)
    7. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PubMed id 19424794)1, 4, 9 (Breast Cancer Res. Treat. 2010)
    8. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    9. Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study. (PubMed id 20621111)1, 4 Siemes C....van Schaik R.H. (Steroids 2010)
    10. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1551 HGNC: 2640 AceView: CYP3A7andCYP3A5P2 Ensembl:ENSG00000160870 euGenes: HUgn1551
    ECgene: CYP3A7 Kegg: 1551 H-InvDB: CYP3A7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP3A7 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp3a7.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP3A7 gene:
    Search GeneIP for patents involving CYP3A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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