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CYP3A7 Gene

protein-coding GIFtS: 65
GCID: GC07M099293

Cytochrome P450, Family 3, Subfamily A, Polypeptide 7

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 7)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 7¹ ²		P450-HFLA²
Cytochrome P450, Subfamily IIIA, Polypeptide 7¹ ²		Aryl Hydrocarbon Hydroxylase²
Cytochrome P450-HFLA² ³		Cytochrome P450 3A7²
CYPIIIA7² ³		Flavoprotein-Linked Monooxygenase²
EC 1.14.14.1³ ⁸		Microsomal Monooxygenase²
CP37²		Xenobiotic Monooxygenase²

External Ids:	HGNC: 2640¹	Entrez Gene: 1551²	Ensembl: ENSG00000160870⁷	OMIM: 605340⁵	UniProtKB: P24462³

Export aliases for CYP3A7 gene to outside databases

Previous GC identifers: GC07M097828 GC07M098890 GC07M098904 GC07M098938 GC07M099135 GC07M099123 GC07M093939

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP3A7 Gene:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids

and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved

in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This

gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described,

but it is not known whether these transcripts are normally produced. This gene undergoes readthrough

transcription with the downstream CYP3AP1 pseudogene, resulting in an isoform with a novel C-terminus, as

represented in GeneID:100861540. (provided by RefSeq, Feb 2012)

GeneCards Summary for CYP3A7 Gene:

CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is

involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated

compounds, including steroids, fatty acids, and xenobiotics

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000007.13 NC_018918.2 NT_007933.16

Regulatory elements:

Regulatory transcription factor binding sites in the CYP3A7 gene promoter:
SRF GR SRF (504 AA) Ik-3 GATA-1 C/EBPalpha PPAR-gamma1 PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP3A7 promoter sequence

Search Chromatin IP Primers for CYP3A7

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21-q22.1

CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A7 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M099293: view genomic region (about GC identifiers)

Start:	99,302,660 bp from pter	End:	99,332,819 bp from pter
Size:	30,160 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 98,662,471-98,692,639

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462 (See protein sequence)

Recommended Name: Cytochrome P450 3A7

Size: 503 amino acids; 57526 Da

Cofactor: Heme group (By similarity)

Secondary accessions: A4D288

Explore the universe of human proteins at neXtProt for CYP3A7: NX_P24462

Explore proteomics data for CYP3A7 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for CYP3A7 (P24462) (see all 17)

SVFTNRR

PGPTPLP

PTFTSGK

NIDPYIY

See CYP3A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000756.2

ENSEMBL proteins:

ENSP00000337450

Reactome Protein details: P24462

CYP3A7 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A7

CYP3 family

4 InterPro protein domains:

IPR008072 Cyt_P450_E_CYP3A

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002402 Cyt_P450_E_grp-II

Graphical View of Domain Structure for InterPro Entry P24462

ProtoNet protein and cluster: P24462

3 Blocks protein domains:

IPB002401 E-class P450 group I signature

IPB002402 Group II E-class P450 signature

IPB008072 CYP3A P450 family signature

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462

Similarity: Belongs to the cytochrome P450 family

Find genes that share domains with CYP3A7 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP3A7_HUMAN, P24462

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is

involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated

compounds, including steroids, fatty acids, and xenobiotics

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including

drugs, pesticides, and carcinogens

Genatlas biochemistry entry for CYP3A7:

cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	ISS	--
GO:0005506	iron ion binding	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--
GO:0019825	oxygen binding	TAS	2722762
GO:0020037	heme binding	IEA	--

Find genes that share ontologies with CYP3A7 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for CYP3A7

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A7

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

CP3A7_HUMAN, P24462: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
extracellular	1
nucleus	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--

Find genes that share ontologies with CYP3A7 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for CYP3A7 About (see all 7)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Biological oxidations

	Biological oxidations	0.56			Phenytoin Pathway, Pharmacokinetics	0.00
	metapathway biotransformation	0.42

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	0.75			cytochrome P450	0.74
	Phase 1 - Functionalization of compounds	0.75			Xenobiotics	0.00

Chemical carcinogenesis

	Chemical carcinogenesis	0.71			Retinol metabolism	0.32
	Retinol metabolism	0.35

Estrone metabolism

Androstenedione and testosterone biosynthesis and metabolism p.1

0.57

Metabolism

Metabolism

0.38

Find genes that share SuperPaths with CYP3A7 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 GeneGo (Thomson Reuters) Pathways for CYP3A7

	Retinol metabolism
	Androstenedione and testosterone biosynthesis and metabolism p.1

2 BioSystems Pathways for CYP3A7

	cytochrome P450
	metapathway biotransformation

1 Reactome Pathway for CYP3A7

Xenobiotics

2 PharmGKB Pathways for CYP3A7

	Carbamazepine Pathway, Pharmacokinetics
	Phenytoin Pathway, Pharmacokinetics

3 Kegg Pathways (Kegg details for CYP3A7):

	Steroid hormone biosynthesis
	Retinol metabolism
	Chemical carcinogenesis

Pathway & Disease-focused RT² Profiler PCR Array including CYP3A7:

Drug Metabolism: Phase I Enzymes in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for CYP3A7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CYP3A7 (ENSP00000337450⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 103)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050
CYP1A2	ENSP00000342007⁴	STRING: ENSP00000342007
CYP26A1	ENSP00000224356⁴	STRING: ENSP00000224356
CYP26B1	ENSP00000001146⁴	STRING: ENSP00000001146
CYP26C1	ENSP00000285949⁴	STRING: ENSP00000285949

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0055114	oxidation-reduction process	--	--

Find genes that share ontologies with CYP3A7 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CYP3A7 (CP3A7)

Selected HMDB Compounds for CYP3A7 (see all 49) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

Selected DrugBank Compounds for CYP3A7 (see all 117) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Midazolam	Dea No. 2884 (see all 4)	59467-70-8	enzyme	substrate inhibitor	8886602 8185679 19934256 11996015
Aminophenazone	4-Dimethylaminoantipyrine (see all 3)	58-15-1	enzyme	substrate	19934256
Amiodarone	Amiodarona [INN-Spanish] (see all 5)	1951-25-3	enzyme	inhibitor	19934256
Buprenorphine	Buprenophine (see all 3)	52485-79-7	enzyme	substrate	19515014
Carbamazepine	Carbamezepine (see all 3)	298-46-4	enzyme	substrate	19934256
Cilostazol	Cilostazole (see all 2)	73963-72-1	enzyme	substrate	10702888
Cimetidine	--	51481-61-9	enzyme	inhibitor	19934256
Cisapride	--	81098-60-4	enzyme	substrate	19934256
Clotrimazole	Chlotrimazole (see all 2)	23593-75-1	enzyme	inducer	19934256
Codeine	Codeine anhydrous (see all 6)	76-57-3	enzyme	substrate	19934256

Selected Novoseek inferred chemical compound relationships for CYP3A7 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
troleandomycin	70.9	5	10950848 (1), 9555064 (1)
2-amino-3-methylimidazo(4,5-f)quinoline	68.7	2	2066864 (1), 7625840 (1)
1-hydroxymidazolam	64.7	1	8185679 (1)
dhea	63.4	10	9644715 (2), 10708604 (1), 9555064 (1), 16041241 (1) (see all 7)
aflatoxin b1	62.5	12	2109655 (3), 2066864 (2), 8638957 (1), 1904422 (1) (see all 6)
dehydroepiandrosterone sulfate	59.5	8	15985487 (3), 2066864 (1), 9555064 (1), 9644715 (1)
midazolam	55.9	2	8185679 (2)
rifampicin	55	12	12673034 (2), 8753820 (2), 17978482 (2), 12843640 (1) (see all 6)
testosterone	45.3	2	9555064 (1), 9644715 (1)
clotrimazole	39.3	2	12673034 (2)

Find genes that share compounds with CYP3A7 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for CYP3A7 gene:

NM_000765.3

Unigene Cluster for CYP3A7:

Cytochrome P450, family 3, subfamily A, polypeptide 7

Hs.111944 [show with all ESTs]

Unigene Representative Sequence: BX647143

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477357 ENST00000336374(uc003uru.3) ENST00000498080 ENST00000467776

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Additional mRNA sequence:

BC067436.1 BC069780.1 BX647143.1 D00408.1

8 DOTS entries:

DT.100775927 DT.101984982 DT.86855768 DT.100775926 DT.100643862 DT.448158 DT.97768778 DT.91749006

Selected AceView cDNA sequences (see all 85):

BX445330 AL531737 BX113858 AI078007 BX503313 BX445329 N39045 D00408

AW299577 AA410229 BC067436 BC069780 AI114634 BI094120 AV694230 NM_000765

CK130234 BX647143 CD013971 CF271966 CK130235 CF271964 CK130233 AA460048

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP3A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTTATATCT

About this image

CYP3A7 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Liver (Hepatobiliary System) fully expand to see all 4 entries
Mature Hepatocytes Liver Lobule
Immature hepatocyte-like cells
Human Hepatocyte (HH)

Spleen (Hematopoietic System)

CYP3A7 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CYP3A7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.111944

Pathway & Disease-focused RT² Profiler PCR Array including CYP3A7:

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyp3a13¹	cytochrome P450, family 3, subfamily a, polypeptide more	79.57(n) 72.46(a)		13113 NM_007819.4 NP_031845.1
chicken (Gallus gallus)	Aves	CYP3A7¹	cytochrome P450 A 37	64.4(n) 59.08(a)		414832 NM_001001751.2 NP_001001751.1
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	59(a) 52(a)	many ↔ many many ↔ many	GL343591.1(16157-77793) GL343987.1(113184-127496)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC100487665¹	cytochrome P450 3A9-like	62.63(n) 59.88(a)		100487665 XM_002933916.2 XP_002933962.1
zebrafish (Danio rerio)	Actinopterygii	cyp3a65¹	cytochrome P450, family 3, subfamily A, polypeptide more	60.61(n) 56.53(a)		553969 NM_001037438.1 NP_001032515.1
rice (Oryza sativa)	Liliopsida	Os02g0221900¹	Os02g0221900	39.7(n) 27.74(a)		4328761 NM_001052860.1 NP_001046325.1

ENSEMBL Gene Tree for CYP3A7 (if available)
TreeFam Gene Tree for CYP3A7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CYP3A7 gene

CYP4F22² TBXAS1² CYP4F3² CYP4F2² CYP4F11² CYP3A43² CYP3A4² CYP4A22²

CYP4V2² CYP4B1² CYP3A5² CYP4A11² CYP4Z1² CYP4F12² CYP4X1²

10 SIMAP similar genes for CYP3A7 using alignment to 3 protein entries: CP3A7_HUMAN (see all proteins):

DKFZp686I18188 CYP3A43/CYP3A4 CYP3A4 CYP3A5 CYP3A43 thromboxane synthase

CYP2C9 TBXAS1 CYP2G1P CYP2E1

Find genes that share paralogs with CYP3A7 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs45577643^1,2	C,F	--	98662313(-)	`GTTCAC/TGCCAT`	1	--	ds500¹		2		--	192
rs139790428^1,2	C	--	99307397(+)	`ATATA-/TGTG TGTGT`	1	--	int¹		0	--	--	--	--
rs145102165^1,2	C	--	99309404(+)	`AACAA-/AACAACAA`	1	--	cds¹		0	--	--	--	--
rs34154522^1,2	C	--	99317220(+)	`AAAAAA/-TATTA`	1	--	int¹		1		NA	2
rs11403618^1,2	C	--	99320650(+)	`AAAAAA/-CCTTC`	1	--	int¹		1		NA	2
rs190085169^1,2		--	102606034(+)	`TTGGCC/TTCCCA`	1	--	ds500¹		0	--	--	--	--
rs145739959^1,2		--	102606247(+)	`GAGATC/TGAGAG`	1	--	ds500¹		0	--	--	--	--
rs182824754^1,2		--	102606306(+)	`TTAGCC/TGGGCG`	1	--	ds500¹		0	--	--	--	--
rs186088668^1,2		--	102606308(+)	`AGCCGA/GGCGTG`	1	--	ds500¹		0	--	--	--	--
rs190756412^1,2		--	102606388(+)	`GAGCTC/TGCAGT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP3A7 (99302660 - 99332819 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for CYP3A7: About this table

Variant ID	Type	Subtype	PubMed ID
esv2734887	CNV	Deletion	23290073
nsv522107	CNV	Loss	19592680
esv29839	CNV	Loss	19812545
nsv888771	CNV	Loss	21882294
esv8941	CNV	Gain	19470904

The Human Cytochrome P450 Allele Nomenclature Database: CYP3A7

Human Gene Mutation Database (HGMD): CYP3A7
Locus Specific Mutation Databases (LSDB): CYP3A7

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 605340 OMIM disorders: --

Find genes that share disorders with CYP3A7 About GenesLikeMe

1 Novoseek inferred disease relationship for CYP3A7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	0	1	10403778 (1)

Genetic Association Database (GAD): CYP3A7
Human Genome Epidemiology (HuGE) Navigator: CYP3A7 (27 documents)

Export disorders for CYP3A7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP3A7 gene, integrated from 10 sources (see all 152):
(articles sorted by number of sources associating them with CYP3A7)

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world of online information

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PubMed id 2722762)^{1, 2, 3} Komori M.... Kamataki T. (J. Biochem. 1989)
Identification of a null allele of cytochrome P450 3A7: CYP3A7 polymorphism in a Korean population. (PubMed id 19585271)^{1, 4, 9} Lee S.S....Shin J.G. (Mol. Biol. Rep. 2010)
Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PubMed id 17559345)^{1, 4, 9} Du J....He L. (Pharmacogenomics 2007)
A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PubMed id 15985487)^{1, 4, 9} Smit P....Lamberts S.W. (J. Clin. Endocrinol. Metab. 2005)
CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PubMed id 18978522)^{1, 4, 9} Crettol S....Eap C.B. (Ther Drug Monit 2008)
Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. (PubMed id 18445661)^{1, 4, 9} Goodarzi M.O....Azziz R. (J. Clin. Endocrinol. Metab. 2008)
Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PubMed id 19424794)^{1, 4, 9} (Breast Cancer Res. Treat. 2010)
Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)^{1, 4} Guey L.T....Malats N. (Eur. Urol. 2010)
Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study. (PubMed id 20621111)^{1, 4} Siemes C....van Schaik R.H. (Steroids 2010)
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)^{1, 4} Jugessur A....Murray J.C. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1551	HGNC: 2640	AceView: CYP3A7andCYP3A5P2	Ensembl:ENSG00000160870	euGenes: HUgn1551
ECgene: CYP3A7	Kegg: 1551	H-InvDB: CYP3A7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP3A7	Pharmacogenomics, SNPs, Pathways
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp3a7.htm

Intellectual Property for CYP3A7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP3A7 gene:
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GeneCards and IP:
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CYP3A7 Gene

Cytochrome P450, Family 3, Subfamily A, Polypeptide 7

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CYP3A7 Gene

Cytochrome P450, Family 3, Subfamily A, Polypeptide 7

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