Aliases for CYP3A7 Gene
External Ids for CYP3A7 Gene
Previous GeneCards Identifiers for CYP3A7 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]
GeneCards Summary for CYP3A7 Gene
CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.
UniProtKB/Swiss-Prot for CYP3A7 Gene
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.