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CYP3A7 Gene(Protein Coding)

Cytochrome P450 Family 3 Subfamily A Member 7

GCID:
GC07M099705
GIFtS:
63
Genes Participants
UDN Logo

Aliases for CYP3A7 Gene

Aliases for CYP3A7 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 7 2 3 5
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 2 3
  • Cytochrome P450, Subfamily IIIA, Polypeptide 7 2 3
  • Cytochrome P450-HFLA 3 4
  • EC 1.14.14.1 4 61
  • CYPIIIA7 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 3A7 3
  • P-450(HFL33) 3
  • P-450111A7 3
  • P450-HFLA 3
  • CP37 3

External Ids for CYP3A7 Gene

Previous GeneCards Identifiers for CYP3A7 Gene

  • GC07M097828
  • GC07M098890
  • GC07M098904
  • GC07M098938
  • GC07M099135
  • GC07M099123
  • GC07M099293
  • GC07M093939
  • GC07M099702

Summaries for CYP3A7 Gene

Entrez Gene Summary for CYP3A7 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7 Gene

CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Phenytoin Pathway, Pharmacokinetics. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP3A7-CYP3A51P.

UniProtKB/Swiss-Prot for CYP3A7 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7 Gene

Genomics for CYP3A7 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CYP3A7 Gene

Enhancers for CYP3A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G099734 0.2 dbSUPER 8.6 -0.2 -198 1.3 CYP3A7 CYP3A7-CYP3A51P CYP3AP2
GH07G099737 0.8 ENCODE dbSUPER 0.7 -2.7 -2736 1.1 ZNF680 ZNF600 PRDM1 ZNF518A CYP3A5 CYP3A7 CYP3A7-CYP3A51P CYP3AP2
GH07G099728 1.4 ENCODE dbSUPER 0.4 +5.5 5547 3.1 FOXA2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 ZSCAN25 TRRAP GIGYF1 LOC100419643 STAG3L5P LOC101927550 ZNF655 ENSG00000242798 MEPCE PPP1R35
GH07G099750 1.3 Ensembl ENCODE dbSUPER 0.4 -16.9 -16900 2.3 PKNOX1 KLF17 ZNF121 ZNF366 FOS ZEB2 ZNF398 SMARCA4 PBX2 ZNF341 CYP3A5 CYP3AP2 CYP3A7 CYP3A7-CYP3A51P
GH07G099742 1.1 ENCODE dbSUPER 0.4 -7.6 -7623 0.1 ELF3 FOXA2 ARID4B THRB RAD21 RARA YY1 ZNF121 CREM MIXL1 CYP3A7 CYP3A7-CYP3A51P CYP3AP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP3A7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYP3A7 gene promoter:

Genomic Location for CYP3A7 Gene

Chromosome:
7
Start:
99,705,037 bp from pter
End:
99,735,200 bp from pter
Size:
30,164 bases
Orientation:
Minus strand

Genomic View for CYP3A7 Gene

Genes around CYP3A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP3A7 Gene

Proteins for CYP3A7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CYP3A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7 Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7 Gene

Protein Expression for CYP3A7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CYP3A7 Gene

P24462:
  • LAVETWLLLAV
  • VLVKECYSVFTN
  • PGPTPLP
  • LSFIIYEL
  • PCKETQIPLK
  • EEWKRIR
  • SVFTNRR
  • PNKAPPTYD
  • RVDFLQLM
  • ALVRVLQNF
  • LLSPTFT
  • LSPTFTSG
  • PTFTSGK
  • NIDPYIY
  • DFLQLMIDSQ
  • KVQKEID
  • PERFSKKN

Post-translational modifications for CYP3A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CYP3A7
  • Cloud-Clone Corp. Antibodies for CYP3A7

Domains & Families for CYP3A7 Gene

Gene Families for CYP3A7 Gene

HGNC:
IUPHAR :

Protein Domains for CYP3A7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP3A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24462

UniProtKB/Swiss-Prot:

CP3A7_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A7: view

Function for CYP3A7 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CYP3A7 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A7 Gene

Gene Ontology (GO) - Molecular Function for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005506 iron ion binding IEA --
GO:0008395 steroid hydroxylase activity IDA 14559847
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP3A7: view
genes like me logo Genes that share phenotypes with CYP3A7: view

Animal Models for CYP3A7 Gene

MGI Knock Outs for CYP3A7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A7 Gene

Localization for CYP3A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CYP3A7: view

Pathways & Interactions for CYP3A7 Gene

genes like me logo Genes that share pathways with CYP3A7: view

Gene Ontology (GO) - Biological Process for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 14559847
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP3A7: view

No data available for SIGNOR curated interactions for CYP3A7 Gene

Drugs & Compounds for CYP3A7 Gene

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  1. Drug

(165) Drugs for CYP3A7 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Enzyme, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
Clarithromycin Approved Pharma Enzyme, substrate, inhibitor 289
Carbamazepine Approved, Investigational Pharma Enzyme, substrate 132
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Enzyme, substrate, inducer 2171
Midazolam Approved, Illicit Pharma Enzyme, substrate, inhibitor 723

(38) Additional Compounds for CYP3A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
 81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
 219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate

(3) ApexBio Compounds for CYP3A7 Gene

Compound Action Cas Number
Clarithromycin 81103-11-9
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
Dafadine-A DAF-9 cytochrome P450 inhibitor 1065506-69-5
genes like me logo Genes that share compounds with CYP3A7: view

Drug Products

Transcripts for CYP3A7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CYP3A7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP3A7 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7 Gene

No ASD Table

Relevant External Links for CYP3A7 Gene

GeneLoc Exon Structure for
CYP3A7
ECgene alternative splicing isoforms for
CYP3A7

Expression for CYP3A7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP3A7 Gene

mRNA expression in normal human tissues for CYP3A7 Gene
mRNA expression by BioGPS for CYP3A7 GenemRNA expression by GTEx for CYP3A7 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A7 Gene

This gene is overexpressed in Liver (x43.8).

Protein differential expression in normal tissues from HIPED for CYP3A7 Gene

This gene is overexpressed in Fetal Liver (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A7 Gene



Protein tissue co-expression partners for CYP3A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP3A7 Gene:

CYP3A7

SOURCE GeneReport for Unigene cluster for CYP3A7 Gene:

Hs.111944

Evidence on tissue expression from TISSUES for CYP3A7 Gene

  • Liver(3.5)
genes like me logo Genes that share expression patterns with CYP3A7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A7 Gene

Orthologs for CYP3A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC100608616 34
  • 99.27 (n)
CYP3A67 35
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cyp3a13 34 16 35
  • 79.57 (n)
Cyp3a11 35
  • 70 (a)
 ManyToMany
Cyp3a41a 35
  • 69 (a)
 ManyToMany
Cyp3a41b 35
  • 69 (a)
 ManyToMany
Cyp3a16 35
  • 68 (a)
 ManyToMany
Cyp3a25 35
  • 67 (a)
 ManyToMany
Cyp3a44 35
  • 67 (a)
 ManyToMany
Cyp3a57 35
  • 66 (a)
 ManyToMany
Cyp3a59 35
  • 65 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Cyp3a9 34
  • 79.13 (n)
dog
(Canis familiaris)
 Mammalia CYP3A12 35
  • 76 (a)
 ManyToMany
CYP3A26 35
  • 74 (a)
 ManyToMany
-- 35
  • 73 (a)
 ManyToMany
-- 35
  • 70 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia -- 35
  • 73 (a)
 ManyToMany
CYP3A5 35 35
  • 70 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 65 (a)
 ManyToMany
-- 35
  • 65 (a)
 ManyToMany
-- 35
  • 63 (a)
 ManyToMany
-- 35
  • 55 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 54 (a)
 ManyToMany
-- 35
  • 53 (a)
 ManyToMany
-- 35
  • 52 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves CYP3A7 34
  • 64.4 (n)
CYP3A37 35
  • 58 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 59 (a)
 ManyToMany
-- 35
  • 52 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487665 34
  • 62.63 (n)
zebrafish
(Danio rerio)
 Actinopterygii cyp3a65 34 35
  • 60.61 (n)
cyp3c1l2 35
  • 49 (a)
 ManyToMany
cyp3c1 35
  • 48 (a)
 ManyToMany
cyp3c4 35
  • 48 (a)
 ManyToMany
si:dkey-21n8.3 35
  • 48 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cyp6a14 36
  • 34 (a)
Cyp6a23 36
  • 34 (a)
Cyp6d4 36
  • 34 (a)
Cyp6g1 36
  • 34 (a)
Cyp6a17 36
  • 33 (a)
Cyp6a13 36
  • 32 (a)
Cyp6a20 36
  • 32 (a)
Cyp6v1 36
  • 32 (a)
Cyp9f2 36
  • 32 (a)
Cyp6a18 36
  • 31 (a)
Cyp6a2 36
  • 31 (a)
Cyp6g2 36
  • 31 (a)
Cyp9b2 36
  • 31 (a)
Cyp6a19 36
  • 30 (a)
Cyp6a22 36
  • 30 (a)
Cyp6a8 36
  • 30 (a)
Cyp6a9 36
  • 30 (a)
Cyp6w1 36
  • 30 (a)
Cyp9c1 36
  • 30 (a)
Cyp6a21 36
  • 29 (a)
Cyp9b1 36
  • 29 (a)
Cyp9h1 36
  • 29 (a)
Cyp28d1 36
  • 28 (a)
Cyp28d2 36
  • 28 (a)
Cyp6d2 36
  • 28 (a)
Cyp6t3 36
  • 27 (a)
Cyp6u1 36
  • 27 (a)
Cyp28a5 36
  • 26 (a)
Cyp28c1 36
  • 25 (a)
Cyp309a2 36
  • 25 (a)
Cyp313a2 36
  • 25 (a)
Cyp6t1 36
  • 25 (a)
Cyp309a1 36
  • 24 (a)
Cyp317a1 36
  • 24 (a)
worm
(Caenorhabditis elegans)
 Secernentea C36A4.1 36
  • 30 (a)
F14F7.2 36
  • 30 (a)
C36A4.2 36
  • 29 (a)
F14F7.3 36
  • 29 (a)
T10B9.5 36
  • 29 (a)
T10B9.7 36
  • 29 (a)
T10B9.8 36
  • 29 (a)
T10B9.1 36
  • 28 (a)
T10B9.2 36
  • 28 (a)
T10B9.3 36
  • 28 (a)
C36A4.6 36
  • 27 (a)
F42A6.4 36
  • 27 (a)
K06G5.2 36
  • 25 (a)
ZK1320.4 36
  • 25 (a)
rice
(Oryza sativa)
 Liliopsida Os02g0221900 34
  • 39.7 (n)
Species where no ortholog for CYP3A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A7 Gene

ENSEMBL:
Gene Tree for CYP3A7 (if available)
TreeFam:
Gene Tree for CYP3A7 (if available)

Paralogs for CYP3A7 Gene

Paralogs for CYP3A7 Gene

(10) SIMAP similar genes for CYP3A7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYP3A7: view

Variants for CYP3A7 Gene

Sequence variations from dbSNP and Humsavar for CYP3A7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000189515 -- 99,723,701(+) CACCA(A/T)TTTTA intron-variant, nc-transcript-variant
rs1000318792 -- 99,735,367(+) TAATA(C/T)TCTAT intron-variant, upstream-variant-2KB
rs1000472813 -- 99,722,816(+) ATTAG(A/G)AAGTT intron-variant
rs1000781448 -- 99,716,579(+) CCCCT(C/G)TCTGC intron-variant
rs1000916923 -- 99,716,245(+) CTGTG(A/C)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A7 Gene

Variant ID Type Subtype PubMed ID
esv2734887 CNV deletion 23290073
esv29839 CNV loss 19812545
esv8941 CNV gain 19470904
nsv522107 CNV loss 19592680
nsv970911 CNV duplication 23825009

Variation tolerance for CYP3A7 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP3A7 Gene

Human Gene Mutation Database (HGMD)
CYP3A7
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A7 Gene

Disorders for CYP3A7 Gene

Relevant External Links for CYP3A7

Genetic Association Database (GAD)
CYP3A7
Human Genome Epidemiology (HuGE) Navigator
CYP3A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A7

No disorders were found for CYP3A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A7 Gene

Publications for CYP3A7 Gene

  1. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) (Breast Cancer Res. Treat. 2010) 3 22 46 64
  2. Identification of a null allele of cytochrome P450 3A7: CYP3A7 polymorphism in a Korean population. (PMID: 19585271) Lee S.S. … Shin J.G. (Mol. Biol. Rep. 2010) 3 22 46 64
  3. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PMID: 18978522) Crettol S. … Eap C.B. (Ther Drug Monit 2008) 3 22 46 64
  4. Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. (PMID: 18445661) Goodarzi M.O. … Azziz R. (J. Clin. Endocrinol. Metab. 2008) 3 22 46 64
  5. Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PMID: 17559345) Du J. … He L. (Pharmacogenomics 2007) 3 22 46 64

Products for CYP3A7 Gene

  • Cloud-Clone Corp. Antibodies for CYP3A7
  • Cloud-Clone Corp. Proteins for CYP3A7
  • Cloud-Clone Corp Assay Kits for CYP3A7

Sources for CYP3A7 Gene

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