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Aliases for CYP3A7 Gene

Aliases for CYP3A7 Gene

  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 2 3
  • Cytochrome P450, Subfamily IIIA, Polypeptide 7 2 3
  • Cytochrome P450-HFLA 3 4
  • EC 1.14.14.1 4 64
  • CYPIIIA7 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 3A7 3
  • P-450(HFL33) 3
  • P-450111A7 3
  • P450-HFLA 3
  • CP37 3

External Ids for CYP3A7 Gene

Summaries for CYP3A7 Gene

Entrez Gene Summary for CYP3A7 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7 Gene

CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP3A7 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7 Gene

Genomics for CYP3A7 Gene

Genomic Location for CYP3A7 Gene

Start:
99,684,679 bp from pter
End:
99,735,196 bp from pter
Size:
50,518 bases
Orientation:
Minus strand

Genomic View for CYP3A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP3A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A7 Gene

Regulatory Elements for CYP3A7 Gene

Proteins for CYP3A7 Gene

  • Protein details for CYP3A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7 Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7 Gene

Proteomics data for CYP3A7 Gene at MOPED

Post-translational modifications for CYP3A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP3A7 Gene

Gene Families for CYP3A7 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

UniProtKB/Swiss-Prot:

CP3A7_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • P24462
genes like me logo Genes that share domains with CYP3A7: view

Function for CYP3A7 Gene

Molecular function for CYP3A7 Gene

GENATLAS Biochemistry: cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP3A7 Gene

Gene Ontology (GO) - Molecular Function for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0019825 oxygen binding TAS 2722762
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP3A7: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP3A7 Gene

Localization for CYP3A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP3A7 Gene COMPARTMENTS Subcellular localization image for CYP3A7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with CYP3A7: view

Pathways for CYP3A7 Gene

genes like me logo Genes that share pathways with CYP3A7: view

Pathways by source for CYP3A7 Gene

Interacting Proteins for CYP3A7 Gene

Gene Ontology (GO) - Biological Process for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP3A7: view

Compounds for CYP3A7 Gene

(49) HMDB Compounds for CYP3A7 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(117) Drugbank Compounds for CYP3A7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alfentanil
  • Alfentanilum [INN-Latin]
71195-58-9 enzyme substrate
Alprazolam
28981-97-7 enzyme substrate
Aminophenazone
  • 4-Dimethylaminoantipyrine
58-15-1 enzyme substrate
Amiodarone
  • Amiodarona [INN-Spanish]
1951-25-3 enzyme inhibitor
Amlodipine
  • Amlodipine Benzenesulfonate
88150-42-9 enzyme substrate

(20) Novoseek inferred chemical compound relationships for CYP3A7 Gene

Compound -log(P) Hits PubMed IDs
troleandomycin 70.9 2
2-amino-3-methylimidazo(4,5-f)quinoline 68.7 2
1-hydroxymidazolam 64.7 1
dhea 63.4 8
aflatoxin b1 62.5 9
genes like me logo Genes that share compounds with CYP3A7: view

Transcripts for CYP3A7 Gene

Unigene Clusters for CYP3A7 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7 Gene

No ASD Table

Relevant External Links for CYP3A7 Gene

GeneLoc Exon Structure for
CYP3A7
ECgene alternative splicing isoforms for
CYP3A7

Expression for CYP3A7 Gene

mRNA expression in normal human tissues for CYP3A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP3A7 Gene

This gene is overexpressed in Liver (43.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP3A7 Gene

SOURCE GeneReport for Unigene cluster for CYP3A7 Gene Hs.111944

genes like me logo Genes that share expressions with CYP3A7: view

Orthologs for CYP3A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A67 37
  • 93 (a)
OneToOne
LOC100608616 36
  • 99.27 (n)
  • 99.2 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 73 (a)
ManyToMany
CYP3A5 37
  • 70 (a)
ManyToMany
CYP3A5 37
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 73 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
CYP3A12 37
  • 76 (a)
ManyToMany
CYP3A26 37
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 37
  • 70 (a)
ManyToMany
Cyp3a13 36
  • 79.57 (n)
  • 72.46 (a)
Cyp3a13 37
  • 72 (a)
ManyToMany
Cyp3a16 37
  • 68 (a)
ManyToMany
Cyp3a25 37
  • 67 (a)
ManyToMany
Cyp3a41a 37
  • 69 (a)
ManyToMany
Cyp3a41b 37
  • 69 (a)
ManyToMany
Cyp3a44 37
  • 67 (a)
ManyToMany
Cyp3a57 37
  • 66 (a)
ManyToMany
Cyp3a59 37
  • 65 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp3a9 36
  • 79.13 (n)
  • 72.96 (a)
chicken
(Gallus gallus)
Aves CYP3A37 37
  • 58 (a)
OneToMany
CYP3A7 36
  • 64.4 (n)
  • 59.08 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487665 36
  • 62.63 (n)
  • 59.88 (a)
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 36
  • 60.61 (n)
  • 56.53 (a)
cyp3a65 37
  • 53 (a)
ManyToMany
cyp3c1 37
  • 48 (a)
ManyToMany
cyp3c1l2 37
  • 49 (a)
ManyToMany
cyp3c4 37
  • 48 (a)
ManyToMany
si:dkey-21n8.3 37
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp6a17 38
  • 33 (a)
Cyp6d2 38
  • 28 (a)
Cyp9b1 38
  • 29 (a)
Cyp313a2 38
  • 25 (a)
Cyp6a2 38
  • 31 (a)
Cyp6g1 38
  • 34 (a)
Cyp317a1 38
  • 24 (a)
Cyp6a21 38
  • 29 (a)
Cyp28d2 38
  • 28 (a)
Cyp6a9 38
  • 30 (a)
Cyp6t3 38
  • 27 (a)
Cyp6w1 38
  • 30 (a)
Cyp28a5 38
  • 26 (a)
Cyp6a19 38
  • 30 (a)
Cyp9f2 38
  • 32 (a)
Cyp9c1 38
  • 30 (a)
Cyp309a2 38
  • 25 (a)
Cyp6t1 38
  • 25 (a)
Cyp9h1 38
  • 29 (a)
Cyp6a23 38
  • 34 (a)
Cyp6a8 38
  • 30 (a)
Cyp6a13 38
  • 32 (a)
Cyp6v1 38
  • 32 (a)
Cyp9b2 38
  • 31 (a)
Cyp28d1 38
  • 28 (a)
Cyp6a14 38
  • 34 (a)
Cyp309a1 38
  • 24 (a)
Cyp6g2 38
  • 31 (a)
Cyp6a18 38
  • 31 (a)
Cyp6d4 38
  • 34 (a)
Cyp6a20 38
  • 32 (a)
Cyp6u1 38
  • 27 (a)
Cyp28c1 38
  • 25 (a)
Cyp6a22 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea T10B9.8 38
  • 29 (a)
K06G5.2 38
  • 25 (a)
T10B9.1 38
  • 28 (a)
T10B9.5 38
  • 29 (a)
F14F7.2 38
  • 30 (a)
F42A6.4 38
  • 27 (a)
C36A4.1 38
  • 30 (a)
ZK1320.4 38
  • 25 (a)
T10B9.2 38
  • 28 (a)
F14F7.3 38
  • 29 (a)
T10B9.7 38
  • 29 (a)
T10B9.3 38
  • 28 (a)
C36A4.6 38
  • 27 (a)
C36A4.2 38
  • 29 (a)
rice
(Oryza sativa)
Liliopsida Os02g0221900 36
  • 39.7 (n)
  • 27.74 (a)
Species with no ortholog for CYP3A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A7 Gene

ENSEMBL:
Gene Tree for CYP3A7 (if available)
TreeFam:
Gene Tree for CYP3A7 (if available)

Paralogs for CYP3A7 Gene

Selected SIMAP similar genes for CYP3A7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYP3A7: view

Variants for CYP3A7 Gene

Sequence variations from dbSNP and Humsavar for CYP3A7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_020124 -
VAR_055564 -

Structural Variations from Database of Genomic Variants (DGV) for CYP3A7 Gene

Variant ID Type Subtype PubMed ID
nsv888771 CNV Loss 21882294
esv2734887 CNV Deletion 23290073
nsv522107 CNV Loss 19592680
esv8941 CNV Gain 19470904
esv29839 CNV Loss 19812545

Relevant External Links for CYP3A7 Gene

HapMap Linkage Disequilibrium report
CYP3A7
Human Gene Mutation Database (HGMD)
CYP3A7
Locus Specific Mutation Databases (LSDB)
CYP3A7
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A7

Disorders for CYP3A7 Gene

(1) Novoseek inferred disease relationships for CYP3A7 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 0 1

Relevant External Links for CYP3A7

Genetic Association Database (GAD)
CYP3A7
Human Genome Epidemiology (HuGE) Navigator
CYP3A7
genes like me logo Genes that share disorders with CYP3A7: view

No data available for UniProtKB/Swiss-Prot for CYP3A7 Gene

Publications for CYP3A7 Gene

  1. A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PMID: 15985487) Smit P. … Lamberts S.W. (J. Clin. Endocrinol. Metab. 2005) 3 23 49
  2. Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PMID: 17559345) Du J. … He L. (Pharmacogenomics 2007) 3 23 49
  3. Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. (PMID: 18445661) Goodarzi M.O. … Azziz R. (J. Clin. Endocrinol. Metab. 2008) 3 23 49
  4. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PMID: 18978522) Crettol S. … Eap C.B. (Ther Drug Monit 2008) 3 23 49
  5. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) (Breast Cancer Res. Treat. 2010) 3 23 49

Products for CYP3A7 Gene

Sources for CYP3A7 Gene

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