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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP3A7 Gene

protein-coding GIFtS: 64
GCID: GC07M099293

cytochrome P450, family 3, subfamily A, polypeptide 7

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 7 )

Explore 13 diseases affiliated with
CYP3A7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 7¹ ²		EC 1.14.14.1³ ⁸
CP37¹ ²		Aryl Hydrocarbon Hydroxylase²
P450-HFLA¹ ²		Cytochrome P450 3A7²
Cytochrome P450, Subfamily IIIA, Polypeptide 7¹ ²		Flavoprotein-Linked Monooxygenase²
Cytochrome P450-HFLA² ³		Microsomal Monooxygenase²
CYPIIIA7² ³		Xenobiotic Monooxygenase²

External Ids:	HGNC: 2640¹	Entrez Gene: 1551²	Ensembl: ENSG00000160870⁷	OMIM: 605340⁵	UniProtKB: P24462³

Export aliases for CYP3A7 gene to outside databases

Previous GC identifers: GC07M097828 GC07M098890 GC07M098904 GC07M098938 GC07M099135 GC07M099123 GC07M093939

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP3A7:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the

formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part

of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not

known whether these transcripts are normally produced. This gene undergoes readthrough transcription with the

downstream CYP3AP1 pseudogene, resulting in an isoform with a novel C-terminus, as represented in GeneID:100861540.

(provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP3A7 gene promoter:
SRF GR SRF (504 AA) Ik-3 GATA-1 C/EBPalpha PPAR-gamma1 PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP3A7 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP3A7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21-q22.1

CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A7 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M099293: view genomic region (about GC identifiers)

Start:	99,302,660 bp from pter	End:	99,332,819 bp from pter
Size:	30,160 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 98,662,471-98,692,639

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462 (See protein sequence)

Recommended Name: Cytochrome P450 3A7

Size: 503 amino acids; 57526 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Secondary accessions: A4D288

Explore the universe of human proteins at neXtProt for CYP3A7: NX_P24462

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P24462

4/17 DME Specific Peptides for CYP3A7 (P24462) (see all 17)

SVFTNRR

PGPTPLP

PTFTSGK

NIDPYIY

CYP3A7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000756.2

ENSEMBL proteins:

ENSP00000337450

Reactome Protein details: P24462
Human Recombinant Protein Products for CYP3A7:

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	Novus Biologicals CYP3A7 Proteins Novus Biologicals CYP3A7 Lysate
	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for CYP3A7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP3A7 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP3A7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP3A7 for domains About GeneDecksing

4 InterPro domains/families:

IPR008072 Cyt_P450_E_CYP3A

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002402 Cyt_P450_E_grp-II

Graphical View of Domain Structure for InterPro Entry P24462

ProtoNet protein and cluster: P24462

3 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB002402 Group II E-class P450 signature

IPB008072 CYP3A P450 family signature

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP3A7_HUMAN, P24462

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs,

pesticides, and carcinogens

Genatlas biochemistry entry for CYP3A7:

cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	ISS	--
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0019825	oxygen binding	TAS	2722762
GO:0020037	heme binding	IEA	--

CYP3A7 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYP3A7

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		Sirion Biotech Custom design and validation of potent shRNA sequences against CYP3A7

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CYP3A7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Xenobiotics

	Xenobiotics	1.00			Carbamazepine Pathway, Pharmacokinetics	0.38
	Phenytoin Pathway, Pharmacokinetics	0.42

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Retinol metabolism

Retinol metabolism

1.00

Retinol metabolism

0.95

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CYP3A7

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Retinol metabolism

2 GeneGo (Thomson Reuters) Pathways for CYP3A7

	Retinol metabolism
	Androstenedione and testosterone biosynthesis and metabolism p.1

2 BioSystems Pathways for CYP3A7

	cytochrome P450
	metapathway biotransformation

5 Reactome Pathways for CYP3A7

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

2 PharmGKB Pathways for CYP3A7

	Carbamazepine Pathway, Pharmacokinetics
	Phenytoin Pathway, Pharmacokinetics

5/7 Kegg Pathways (Kegg details for CYP3A7) (see all 7):

	Steroid hormone biosynthesis
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

CYP3A7 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP3A7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/97 Interacting proteins for CYP3A7 (ENSP00000337450⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 97)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050
CYP1A2	ENSP00000342007⁴	STRING: ENSP00000342007
CYP26A1	ENSP00000224356⁴	STRING: ENSP00000224356
CYP26B1	ENSP00000001146⁴	STRING: ENSP00000001146
CYP26C1	ENSP00000285949⁴	STRING: ENSP00000285949

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CYP3A7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP3A7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP3A7

10/49 HMDB Compounds for CYP3A7 (see all 49) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

10/115 DrugBank Compounds for CYP3A7 (see all 115) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Midazolam	Dea No. 2884 (see all 4)	59467-70-8	enzyme	substrate inhibitor	8886602 8185679 19934256 11996015
Aminophenazone	4-Dimethylaminoantipyrine (see all 3)	58-15-1	enzyme	substrate	19934256
Amiodarone	Amiodarona [INN-Spanish] (see all 5)	1951-25-3	enzyme	inhibitor	19934256
Buprenorphine	Buprenophine (see all 4)	52485-79-7	enzyme	substrate	19515014
Carbamazepine	--	298-46-4	enzyme	substrate	19934256
Cilostazol	Cilostazole (see all 2)	73963-72-1	enzyme	substrate	10702888
Cimetidine	--	51481-61-9	enzyme	inhibitor	19934256
Cisapride	--	81098-60-4	enzyme	substrate	19934256
Clotrimazole	Chlotrimazole (see all 2)	23593-75-1	enzyme	inducer	19934256
Codeine	Codeine anhydrous (see all 6)	76-57-3	enzyme	substrate	19934256

10/20 Novoseek chemical compound relationships for CYP3A7 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
troleandomycin	70.9	5	10950848 (1), 9555064 (1)
2-amino-3-methylimidazo(4,5-f)quinoline	68.7	2	2066864 (1), 7625840 (1)
1-hydroxymidazolam	64.7	1	8185679 (1)
dhea	63.4	10	9644715 (2), 10708604 (1), 9555064 (1), 16041241 (1) (see all 7)
aflatoxin b1	62.5	12	2109655 (3), 2066864 (2), 8638957 (1), 1904422 (1) (see all 6)
dehydroepiandrosterone sulfate	59.5	8	15985487 (3), 2066864 (1), 9555064 (1), 9644715 (1)
midazolam	55.9	2	8185679 (2)
rifampicin	55	12	12673034 (2), 8753820 (2), 17978482 (2), 12843640 (1) (see all 6)
testosterone	45.3	2	9555064 (1), 9644715 (1)
clotrimazole	39.3	2	12673034 (2)

Search CenterWatch for drugs/clinical trials and news about CYP3A7 / CP3A7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP3A7 gene:

NM_000765.3

Unigene Cluster for CYP3A7:

Cytochrome P450, family 3, subfamily A, polypeptide 7

Hs.111944 [show with all ESTs]

Unigene Representative Sequence: BX647143

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477357 ENST00000336374(uc003uru.3) ENST00000498080 ENST00000467776

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		GenScript: all cDNA clones in your preferred vector: CYP3A7 (NM_000765)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP3A7
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3A7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3A7

Additional cDNA sequence:

BC067436.1 BC069780.1 BX647143.1 D00408.1

8 DOTS entries:

DT.100775927 DT.101984982 DT.86855768 DT.100775926 DT.448158 DT.100643862 DT.97768778 DT.91749006

24/85 AceView cDNA sequences (see all 85):

AI078007 BX113858 AL531737 BX503313 BX445330 BC069780 BX463042 T28536

T96637 AI114634 CF271965 CK032888 AW299577 CF271964 BX449069 BX647143

N39045 CK032861 BX643367 AW102625 AF315325 CK130233 AA334375 CD013971

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP3A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTATATCT

About this image

CYP3A7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Immature hepatocyte-like cells (Generation of hepato...)

See CYP3A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP3A7

SOURCE GeneReport for Unigene cluster: Hs.111944

SABiosciences Expression via Pathway-Focused PCR Array including CYP3A7:

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CYP3A7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CYP3A7 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NT18_CHICK⁶	cytochrome P450 A 37	58(a)	1 → many	14(3939211-3948991)
lizard (Anolis carolinensis)	Reptilia	--	--	53(a)	1 → many	GL343987.1(114011-127496)
zebrafish (Danio rerio)	Actinopterygii	cyp3a65⁶	cytochrome P450, family 3, subfamily A, polypeptid...	53(a)	possible ortholog	1(60208634-60218577)
fruit fly (Drosophila melanogaster)	Insecta	Cyp6g1³	DDT resistance cytochrome P450	34(a) (best of 34)		2 48E7 --

ENSEMBL Gene Tree for CYP3A7 (if available)
TreeFam Gene Tree for CYP3A7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CYP3A7 gene

CYP4F22² CYP4F3² CYP4F2² CYP4F11² CYP46A1² ENSG00000225607² CYP4B1² CYP3A5²

CYP4X1² TBXAS1² CYP3A4² CYP3A43² CYP4V2² CYP4A22² CYP4A11² CYP4F12²

CYP4Z1²

10 SIMAP similar genes for CYP3A7 using alignment to 3 protein entries: CP3A7_HUMAN (see all proteins):

DKFZp686I18188 CYP3A43/CYP3A4 CYP3A4 CYP3A5 CYP3A43 thromboxane synthase

TBXAS1 CYP2C9 CYP2G1P CYP2E1

CYP3A7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs45577643^1,2	C,F	--	98662313(-)	`GTTCAC/TGCCAT`	1	--	ds500¹		2		--	192
rs4646468^1,2	C,H	--	98662812(-)	`GCATAA/CATAAT`	1	--	ut3¹		7		NS EA NA	696
rs4646467^1,2		--	98663099(-)	`TTTTT-/TACTTT`	1	--	int¹		0	--	--	--	--
rs6965239^1,2	C	--	98663782(+)	`CATCCT/CAGGTG`	1	--	int¹		4		NA	314
rs78763483^1,2	F	--	98664229(+)	`CCAATC/TGACTG`	1	--	int¹		1		NA	120
rs78365260^1,2	F	--	98664544(+)	`AAGAAC/TAGAAT`	1	--	int¹		1		WA	118
rs45593341^1,2	C	--	98664722(-)	`CTCATG/TTGAAG`	1	--	int¹		5		WA NA	432
rs45460091^1,2	C	--	98665161(-)	`ACTCAC/TTTAAT`	1	--	int¹		4		CSA WA	312
rs41279860^1,2		--	98665677(+)	`CTCAAA/GTTATA`	1	--	int¹		0	--	--	--	--
rs45479693^1,2	C,F	--	98665912(-)	`AAGGAG/AGAGAG`	1	--	int¹		2		--	192

HapMap Linkage Disequilibrium report for CYP3A7 (99302660 - 99332819 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYP3A7
1 CNV: 70009
1 Indel: 60671
Human Gene Mutation Database (HGMD): CYP3A7

Locus Specific Mutation Databases (LSDB): CYP3A7

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP3A7 for disorders           About GeneDecksing

OMIM gene information: 605340    OMIM disorders: --

13 diseases for CYP3A7:    About MalaCards

cholesterol polycystic ovary syndrome epithelial ovarian cancer hepatocellular carcinoma

ovarian cancer duodenitis pulmonary disease nasopharyngitis

prostate cancer breast cancer carcinoma prostatitis

hepatitis

1 Novoseek disease relationship for CYP3A7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	0	1	10403778 (1)

Genetic Association Database (GAD): CYP3A7
Human Genome Epidemiology (HuGE) Navigator: CYP3A7 (27 documents)

Export disorders for CYP3A7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP3A7 gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with CYP3A7)

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Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PubMed id 2722762)^{1, 2, 3} Komori M.... Kamataki T. (1989)
A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PubMed id 15985487)^{1, 4, 9} Smit P....Lamberts S.W. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PubMed id 11266076)^{1, 2} Gellner K....Wojnowski L. (2001)
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. (PubMed id 11093772)^{1, 7} Marill J....Chabot G.G. (2000)
Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family. (PubMed id 2492179)^{1, 2} Wrighton S.A. and Vandenbranden M. (1989)
Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers. (PubMed id 2786707)^{1, 2} Komori M.... Kamataki T. (1989)
Identification of a null allele of cytochrome P450 3A 7: CYP3A7 polymorphism in a Korean population. (PubMed id 19585271)^{1, 9} Lee S.S....Shin J.G. (2010)
CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele. (PubMed id 16041241)^{1, 9} Sim S.C....Ingelman-Sundberg M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1551	HGNC: 2640	AceView: CYP3A7andCYP3A5P2	Ensembl:ENSG00000160870	euGenes: HUgn1551
ECgene: CYP3A7	Kegg: 1551	H-InvDB: CYP3A7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP3A7	Pharmacogenomics, SNPs, Pathways
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp3a7.htm

Intellectual Property for CYP3A7 gene
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Patent Information for CYP3A7 gene:
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CYP3A7 Gene

cytochrome P450, family 3, subfamily A, polypeptide 7

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CYP3A7 Gene

cytochrome P450, family 3, subfamily A, polypeptide 7

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