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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP3A7 Gene

protein-coding   GIFtS: 66
GCID: GC07M099293

Cytochrome P450, Family 3, Subfamily A, Polypeptide 7

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 7)
  See related diseases
at
MalaCards
 

Aliases
for CYP3A7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 71 2     P450-HFLA2
Cytochrome P450, Subfamily IIIA, Polypeptide 71 2     Aryl Hydrocarbon Hydroxylase2
Cytochrome P450-HFLA2 3     Cytochrome P450 3A72
CYPIIIA72 3     Flavoprotein-Linked Monooxygenase2
EC 1.14.14.13 8     Microsomal Monooxygenase2
CP372     Xenobiotic Monooxygenase2

External Ids:    HGNC: 26401   Entrez Gene: 15512   Ensembl: ENSG000001608707   OMIM: 6053405   UniProtKB: P244623   

Export aliases for CYP3A7 gene to outside databases

Previous GC identifers: GC07M097828 GC07M098890 GC07M098904 GC07M098938 GC07M099135 GC07M099123 GC07M093939


Summaries
for CYP3A7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP3A7 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved
in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This
gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described,
but it is not known whether these transcripts are normally produced. This gene undergoes readthrough
transcription with the downstream CYP3AP1 pseudogene, resulting in an isoform with a novel C-terminus, as
represented in GeneID:100861540. (provided by RefSeq, Feb 2012)

GeneCards Summary for CYP3A7 Gene: 
CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) is a protein-coding gene. Diseases associated with CYP3A7 include cytochrome p450, and polycystic ovary syndrome, and among its related super-pathways are Cytochrome P450 - arranged by substrate type and Phase II conjugation. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics




Genomic Views
for CYP3A7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP3A7 gene promoter:
         SRF   GR   SRF (504 AA)   Ik-3   GATA-1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP3A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP3A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21-q22.1

CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099293:  view genomic region     (about GC identifiers)

Start:
 99,302,660 bp from pter      End:
 99,332,819 bp from pter
Size:
 30,160 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,662,471-98,692,639     

Proteins
for CYP3A7 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462 (See protein sequence)
Recommended Name: Cytochrome P450 3A7  
Size: 503 amino acids; 57526 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: A4D288

Explore the universe of human proteins at neXtProt for CYP3A7: NX_P24462

Explore proteomics data for CYP3A7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24462

    • 4/17 DME Specific Peptides for CYP3A7 (P24462) (see all 17)
     SVFTNRR  PGPTPLP  PTFTSGK  NIDPYIY 

    CYP3A7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP3A7 Protein Expression
    REFSEQ proteins: NP_000756.2  
    ENSEMBL proteins: 
     ENSP00000337450  
    Reactome Protein details: P24462
    Human Recombinant Protein Products for CYP3A7: 
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    Cloud-Clone Corp. Proteins for CYP3A7 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    CYP3A7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CYP3A7 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A7 
    CYP3 family

    4 InterPro protein domains:
     IPR008072 Cyt_P450_E_CYP3A
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002402 Cyt_P450_E_grp-II

    Graphical View of Domain Structure for InterPro Entry P24462

    ProtoNet protein and cluster: P24462

    3 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB002402 Group II E-class P450 signature
    IPB008072 CYP3A P450 family signature


    UniProtKB/Swiss-Prot: CP3A7_HUMAN, P24462
    Similarity: Belongs to the cytochrome P450 family


    CYP3A7 for domains           About GeneDecksing


    Function
    for CYP3A7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP3A7_HUMAN, P24462
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including
    drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP3A7:
    cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ISS--
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0019825oxygen binding TAS2722762
         
    CYP3A7 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Pathways & Interactions
    for CYP3A7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP3A7 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type0.75
    		Phase 1 - Functionalization of compounds0.74
    		cytochrome P4500.75
    2Biological oxidations
    		Biological oxidations0.55
    		metapathway biotransformation0.41
    3Metabolism
    		Metabolism0.40
    		Metabolic pathways0.40
    4Drug metabolism - cytochrome P450
    		Metabolism of xenobiotics by cytochrome P4500.77
    		Drug metabolism - cytochrome P4500.73
    		Chemical carcinogenesis0.77
    		Retinol metabolism0.39
    5Carbamazepine Pathway, Pharmacokinetics
    		Carbamazepine Pathway, Pharmacokinetics0.38
    		Phenytoin Pathway, Pharmacokinetics0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CYP3A7
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Retinol metabolism


    2 GeneGo (Thomson Reuters) Pathways for CYP3A7
        Retinol metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    2 BioSystems Pathways for CYP3A7
        cytochrome P450
    metapathway biotransformation


    5        Reactome Pathways for CYP3A7
        Cytochrome P450 - arranged by substrate type
    Xenobiotics
    Metabolism
    Biological oxidations
    Phase 1 - Functionalization of compounds

    2 PharmGKB Pathways for CYP3A7
        Carbamazepine Pathway, Pharmacokinetics
    Phenytoin Pathway, Pharmacokinetics

    5/8         Kegg Pathways  (Kegg details for CYP3A7) (see all 8):
        Steroid hormone biosynthesis
    Linoleic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450


    CYP3A7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP3A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for CYP3A7 (ENSP000003374504) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    CYP26B1ENSP000000011464STRING: ENSP00000001146
    CYP26C1ENSP000002859494STRING: ENSP00000285949
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    CYP3A7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYP3A7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP3A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP3A7 (CP3A7)

    10/49 HMDB Compounds for CYP3A7 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    10/117 DrugBank Compounds for CYP3A7 (see all 117)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MidazolamDea No. 2884 (see all 4)59467-70-8enzymesubstrate inhibitor8886602 8185679 19934256 11996015
    Aminophenazone4-Dimethylaminoantipyrine (see all 3)58-15-1enzymesubstrate19934256
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymeinhibitor19934256
    BuprenorphineBuprenophine (see all 3)52485-79-7enzymesubstrate19515014
    CarbamazepineCarbamezepine (see all 3)298-46-4enzymesubstrate19934256
    CilostazolCilostazole (see all 2)73963-72-1enzymesubstrate10702888
    Cimetidine-- 51481-61-9enzymeinhibitor19934256
    Cisapride-- 81098-60-4enzymesubstrate19934256
    ClotrimazoleChlotrimazole (see all 2)23593-75-1enzymeinducer19934256
    CodeineCodeine anhydrous (see all 6)76-57-3enzymesubstrate19934256

    10/20 Novoseek inferred chemical compound relationships for CYP3A7 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    troleandomycin 70.9 5 10950848 (1), 9555064 (1)
    2-amino-3-methylimidazo(4,5-f)quinoline 68.7 2 2066864 (1), 7625840 (1)
    1-hydroxymidazolam 64.7 1 8185679 (1)
    dhea 63.4 10 9644715 (2), 10708604 (1), 9555064 (1), 16041241 (1) (see all 7)
    aflatoxin b1 62.5 12 2109655 (3), 2066864 (2), 8638957 (1), 1904422 (1) (see all 6)
    dehydroepiandrosterone sulfate 59.5 8 15985487 (3), 2066864 (1), 9555064 (1), 9644715 (1)
    midazolam 55.9 2 8185679 (2)
    rifampicin 55 12 12673034 (2), 8753820 (2), 17978482 (2), 12843640 (1) (see all 6)
    testosterone 45.3 2 9555064 (1), 9644715 (1)
    clotrimazole 39.3 2 12673034 (2)

    Search CenterWatch for drugs/clinical trials and news about CYP3A7 / CP3A7

    Transcripts
    for CYP3A7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for CYP3A7 gene: 
    NM_000765.3  

    Unigene Cluster for CYP3A7:

    Cytochrome P450, family 3, subfamily A, polypeptide 7
    Hs.111944  [show with all ESTs]
    Unigene Representative Sequence: BX647143
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477357 ENST00000336374(uc003uru.3) ENST00000498080 ENST00000467776

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    Primer
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    Additional mRNA sequence: 

    BC067436.1 BC069780.1 BX647143.1 D00408.1 

    8 DOTS entries:

    DT.100775927  DT.101984982  DT.86855768  DT.100775926  DT.100643862  DT.448158  DT.97768778  DT.91749006 

    24/85 AceView cDNA sequences (see all 85):

    BX113858 AI078007 BX503313 AL531737 BX445330 BX449069 BX497196 CK130233 
    BX388061 CK130235 AF315325 AI114634 BC067436 AA410229 AA777496 N39045 
    CF271964 CK032888 CF271965 AA460048 CK032861 BC069780 BX428031 BX463042 

    GeneLoc Exon Structure


    Expression
    for CYP3A7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP3A7 expression in normal human tissues (normalized intensities)      CYP3A7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTATATCT
    CYP3A7 Expression
    About this image


    CYP3A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Mature Hepatocytes Liver Lobule
             Human Hepatocyte (HH)   
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-154
     
     Spleen (Hematopoietic System)

    See CYP3A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP3A7

    SOURCE GeneReport for Unigene cluster: Hs.111944
        SABiosciences Expression via Pathway-Focused PCR Array including CYP3A7: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    Orthologs
    for CYP3A7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CYP3A7 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CYP3A46
    CYP3A76
    		 cytochrome P450 A 37
    		 58(a)
    58(a)
    		 possible ortholog
    1 ↔ many
    		 14(3884372-3894819)
    14(3919206-3928547)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 61(a)
    60(a)
    (see all 4)    		 possible ortholog
    many ↔ many
    (see all 4)    		 GL343987.1(68581-71922)
    GL343591.1(16157-77793)
    zebrafish
    (Danio rerio)    		 Actinopterygii cyp3a656
    cyp3c1l26
    (see all 5)    		 cytochrome P450, family 3, subfamily A, polypeptid...
    cytochrome P450, family 3, subfamily c, polypeptid...
    (see all 5)    		 53(a)
    48(a)
    (see all 5)    		 1 ↔ many
    possible ortholog
    (see all 5)    		 1(60208634-60218577)
    3(40942743-40950564)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cyp6g13 DDT resistance cytochrome P450 34(a)
    (best of 34)    		   2 48E7   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F14F7.23 cytochrome P450 30(a)
    (best of 14)    		   III(13092293-13095233)   --
            Species with no ortholog for CYP3A7

    ENSEMBL Gene Tree for CYP3A7 (if available)
    TreeFam Gene Tree for CYP3A7 (if available)

    Paralogs
    for CYP3A7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP3A7 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    10 SIMAP similar genes for CYP3A7 using alignment to 3 protein entries:     CP3A7_HUMAN (see all proteins):
    DKFZp686I18188    CYP3A43/CYP3A4    CYP3A4    CYP3A5    CYP3A43    thromboxane synthase
    CYP2C9    TBXAS1    CYP2G1P    CYP2E1

    CYP3A7 for paralogs           About GeneDecksing



    Genomic Variants
    for CYP3A7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/715 SNPs in CYP3A7 are shown (see all 715)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs455776431,2
    		C,F--98662313(-) GTTCAC/TGCCAT 1 -- ds50012Minor allele frequency- T:0.02--192
    rs1397904281,2
    		C--99307397(+) ATATA-/TGTG  
                TGTGT     		1 -- int10--------
    rs1451021651,2
    		C--99309404(+) AACAA-/AACAACAA 1 -- cds10--------
    rs341545221,2
    		C--99317220(+) AAAAAA/-TATTA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs114036181,2
    		C--99320650(+) AAAAAA/-CCTTC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1900851691,2
    		--102606034(+) TTGGCC/TTCCCA 1 -- ds50010--------
    rs1457399591,2
    		--102606247(+) GAGATC/TGAGAG 1 -- ds50010--------
    rs1828247541,2
    		--102606306(+) TTAGCC/TGGGCG 1 -- ds50010--------
    rs1860886681,2
    		--102606308(+) AGCCGA/GGCGTG 1 -- ds50010--------
    rs1907564121,2
    		--102606388(+) GAGCTC/TGCAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CYP3A7 (99302660 - 99332819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CYP3A7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734887CNV Deletion23290073
    nsv522107CNV Loss19592680
    esv29839CNV Loss19812545
    nsv888771CNV Loss21882294
    esv8941CNV Gain19470904


    Human Gene Mutation Database (HGMD): CYP3A7

    Locus Specific Mutation Databases (LSDB): CYP3A7
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A7
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    Disorders / Diseases
    for CYP3A7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 605340    OMIM disorders: --

    10 diseases for CYP3A7:    About MalaCards
    cytochrome p450    polycystic ovary syndrome    duodenitis    nasopharyngitis
    ovarian cancer    prostate cancer    prostatitis    hepatitis
    lung cancer    breast cancer


    CYP3A7 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYP3A7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 0 1 10403778 (1)

    Genetic Association Database (GAD): CYP3A7
    Human Genome Epidemiology (HuGE) Navigator: CYP3A7 (27 documents)

    Export disorders for CYP3A7 gene to outside databases

    Publications
    for CYP3A7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP3A7 gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with CYP3A7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PubMed id 2722762)1, 2, 3 Komori M.... Kamataki T. (1989)
    2. Identification of a null allele of cytochrome P450 3A 7: CYP3A7 polymorphism in a Korean population. (PubMed id 19585271)1, 4, 9 Lee S.S....Shin J.G. (2010)
    3. Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PubMed id 17559345)1, 4, 9 Du J....He L. (2007)
    4. A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PubMed id 15985487)1, 4, 9 Smit P....Lamberts S.W. (2005)
    5. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PubMed id 18978522)1, 4, 9 Crettol S....Eap C.B. (2008)
    6. Association of CYP3A7*1C and Serum Dehydroepiandrosterone Sulfate Levels in Women with Polycystic Ovary Syndrome. (PubMed id 18445661)1, 4, 9 Goodarzi M.O....Azziz R. (2008)
    7. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PubMed id 19424794)1, 4, 9 (2009)
    8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    9. Cytochrome P450 3A gene variation, steroid hormone se rum levels and prostate cancer--The Rotterdam Study. (PubMed id 20621111)1, 4 Siemes C....van Schaik R.H. (2010)
    10. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)

    External Searches for CYP3A7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYP3A7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1551 HGNC: 2640 AceView: CYP3A7andCYP3A5P2 Ensembl:ENSG00000160870 euGenes: HUgn1551
    ECgene: CYP3A7 Kegg: 1551 H-InvDB: CYP3A7

    Other Databases showing CYP3A7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP3A7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP3A7 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp3a7.htm

    Intellectual Property
    for CYP3A7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP3A7 gene:
    Search GeneIP for patents involving CYP3A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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