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CYP3A7 Gene(Protein Coding)

Cytochrome P450 Family 3 Subfamily A Member 7

GCID:
GC07M099705
GIFtS:
53
Genes Participants
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Aliases for CYP3A7 Gene

Aliases for CYP3A7 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 7 2 3 5
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 2 3
  • Cytochrome P450, Subfamily IIIA, Polypeptide 7 2 3
  • Cytochrome P450-HFLA 3 4
  • EC 1.14.14.1 4 56
  • CYPIIIA7 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 3A7 3
  • P-450(HFL33) 3
  • P-450111A7 3
  • P450-HFLA 3
  • CP37 3

External Ids for CYP3A7 Gene

Previous GeneCards Identifiers for CYP3A7 Gene

  • GC07M097828
  • GC07M098890
  • GC07M098904
  • GC07M098938
  • GC07M099135
  • GC07M099123
  • GC07M099293
  • GC07M093939
  • GC07M099702

Summaries for CYP3A7 Gene

Entrez Gene Summary for CYP3A7 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7 Gene

CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP3A7-CYP3A51P.

UniProtKB/Swiss-Prot for CYP3A7 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Additional gene information for CYP3A7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7 Gene

Genomics for CYP3A7 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CYP3A7 Gene

Promoters and enhancers for CYP3A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07I099735 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +0.0 29 0.1 CYP3A7 CYP3A7-CYP3A51P PIR41599 ZSCAN25
GH07I099737 Enhancer 0.7 ENCODE dbSUPER 0.8 -2.7 -2735 1.1 ZNF680 ZNF600 PRDM1 ZNF518A CYP3A5 CYP3A7 CYP3A7-CYP3A51P CYP3AP2 ZSCAN25
GH07I099750 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 -16.9 -16899 2.3 DRAP1 MEIS2 PKNOX1 KLF17 ZIC2 FOSL1 GATA3 ZNF366 PATZ1 FOS CYP3AP2 CYP3A5 CYP3A7 CYP3A7-CYP3A51P
GH07I099742 Enhancer 1 ENCODE dbSUPER 0.4 -7.6 -7623 0.1 ELF3 FOXA2 ARID4B THRB RAD21 RARA YY1 CREM MIXL1 RXRA CYP3A7 CYP3A7-CYP3A51P CYP3AP2
GH07I099728 Enhancer 1 ENCODE dbSUPER 0.4 +5.5 5547 3.1 PKNOX1 FOXA2 ARID4B FEZF1 ZBTB40 RAD21 ATF7 HMG20B USF2 CEBPB CYP3A5 ZSCAN25 ZKSCAN5 PIR41599 CYP3A7 CYP3A7-CYP3A51P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYP3A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP3A7 gene promoter:

Genomic Locations for CYP3A7 Gene

Genomic Locations for CYP3A7 Gene
chr7:99,705,037-99,735,200
(GRCh38/hg38)
Size:
30,164 bases
Orientation:
Minus strand
chr7:99,302,660-99,332,819
(GRCh37/hg19)

Genomic View for CYP3A7 Gene

Genes around CYP3A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP3A7 Gene

Proteins for CYP3A7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CYP3A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7 Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7 Gene

Protein Expression for CYP3A7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CYP3A7 Gene

P24462:
  • LAVETWLLLAV
  • VLVKECYSVFTN
  • PGPTPLP
  • LSFIIYEL
  • PCKETQIPLK
  • EEWKRIR
  • SVFTNRR
  • PNKAPPTYD
  • RVDFLQLM
  • ALVRVLQNF
  • LLSPTFT
  • LSPTFTSG
  • PTFTSGK
  • NIDPYIY
  • DFLQLMIDSQ
  • KVQKEID
  • PERFSKKN

Post-translational modifications for CYP3A7 Gene

No Post-translational modifications

Other Protein References for CYP3A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP3A7 Gene

Gene Families for CYP3A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CYP3A7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP3A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24462

UniProtKB/Swiss-Prot:

CP3A7_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A7: view

Function for CYP3A7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CYP3A7 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A7 Gene

Gene Ontology (GO) - Molecular Function for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005506 iron ion binding IEA --
GO:0008395 steroid hydroxylase activity IDA 14559847
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP3A7: view
genes like me logo Genes that share phenotypes with CYP3A7: view

Animal Models for CYP3A7 Gene

MGI Knock Outs for CYP3A7:

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A7 Gene

Localization for CYP3A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CYP3A7: view

Pathways & Interactions for CYP3A7 Gene

genes like me logo Genes that share pathways with CYP3A7: view

Gene Ontology (GO) - Biological Process for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 14559847
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP3A7: view

No data available for SIGNOR curated interactions for CYP3A7 Gene

Drugs & Compounds for CYP3A7 Gene

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  1. Drug

(179) Drugs for CYP3A7 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Enzyme, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2040
Clarithromycin Approved Pharma Enzyme, substrate, inhibitor 312
Carbamazepine Approved, Investigational Pharma Enzyme, substrate 134
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Enzyme, substrate, inducer 2314
Midazolam Approved, Illicit Pharma Enzyme, substrate, inhibitor 806

(38) Additional Compounds for CYP3A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
 81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
 219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate

(3) ApexBio Compounds for CYP3A7 Gene

Compound Action Cas Number
Clarithromycin 81103-11-9
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
Dafadine-A DAF-9 cytochrome P450 inhibitor 1065506-69-5
genes like me logo Genes that share compounds with CYP3A7: view

Drug Products

Transcripts for CYP3A7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CYP3A7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP3A7 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7 Gene

No ASD Table

Relevant External Links for CYP3A7 Gene

GeneLoc Exon Structure for
CYP3A7
ECgene alternative splicing isoforms for
CYP3A7

Expression for CYP3A7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP3A7 Gene

mRNA expression in normal human tissues for CYP3A7 Gene
mRNA expression by BioGPS for CYP3A7 GenemRNA expression by GTEx for CYP3A7 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A7 Gene

This gene is overexpressed in Liver (x43.8).

Protein differential expression in normal tissues from HIPED for CYP3A7 Gene

This gene is overexpressed in Fetal Liver (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A7 Gene



Protein tissue co-expression partners for CYP3A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP3A7 Gene:

CYP3A7

SOURCE GeneReport for Unigene cluster for CYP3A7 Gene:

Hs.111944

Evidence on tissue expression from TISSUES for CYP3A7 Gene

  • Liver(3.5)
genes like me logo Genes that share expression patterns with CYP3A7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A7 Gene

Orthologs for CYP3A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC100608616 33
  • 99.27 (n)
CYP3A67 34
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cyp3a13 33 16 34
  • 79.57 (n)
Cyp3a11 34
  • 70 (a)
 ManyToMany
Cyp3a41a 34
  • 69 (a)
 ManyToMany
Cyp3a41b 34
  • 69 (a)
 ManyToMany
Cyp3a16 34
  • 68 (a)
 ManyToMany
Cyp3a25 34
  • 67 (a)
 ManyToMany
Cyp3a44 34
  • 67 (a)
 ManyToMany
Cyp3a57 34
  • 66 (a)
 ManyToMany
Cyp3a59 34
  • 65 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Cyp3a9 33
  • 79.13 (n)
dog
(Canis familiaris)
 Mammalia CYP3A12 34
  • 76 (a)
 ManyToMany
CYP3A26 34
  • 74 (a)
 ManyToMany
-- 34
  • 73 (a)
 ManyToMany
-- 34
  • 70 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia -- 34
  • 73 (a)
 ManyToMany
CYP3A5 34 34
  • 70 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 65 (a)
 ManyToMany
-- 34
  • 65 (a)
 ManyToMany
-- 34
  • 63 (a)
 ManyToMany
-- 34
  • 55 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 54 (a)
 ManyToMany
-- 34
  • 53 (a)
 ManyToMany
-- 34
  • 52 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves CYP3A7 33
  • 64.4 (n)
CYP3A37 34
  • 58 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 59 (a)
 ManyToMany
-- 34
  • 52 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487665 33
  • 62.63 (n)
zebrafish
(Danio rerio)
 Actinopterygii cyp3a65 33 34
  • 60.61 (n)
cyp3c1l2 34
  • 49 (a)
 ManyToMany
cyp3c1 34
  • 48 (a)
 ManyToMany
cyp3c4 34
  • 48 (a)
 ManyToMany
si:dkey-21n8.3 34
  • 48 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cyp6a14 35
  • 34 (a)
Cyp6a23 35
  • 34 (a)
Cyp6d4 35
  • 34 (a)
Cyp6g1 35
  • 34 (a)
Cyp6a17 35
  • 33 (a)
Cyp6a13 35
  • 32 (a)
Cyp6a20 35
  • 32 (a)
Cyp6v1 35
  • 32 (a)
Cyp9f2 35
  • 32 (a)
Cyp6a18 35
  • 31 (a)
Cyp6a2 35
  • 31 (a)
Cyp6g2 35
  • 31 (a)
Cyp9b2 35
  • 31 (a)
Cyp6a19 35
  • 30 (a)
Cyp6a22 35
  • 30 (a)
Cyp6a8 35
  • 30 (a)
Cyp6a9 35
  • 30 (a)
Cyp6w1 35
  • 30 (a)
Cyp9c1 35
  • 30 (a)
Cyp6a21 35
  • 29 (a)
Cyp9b1 35
  • 29 (a)
Cyp9h1 35
  • 29 (a)
Cyp28d1 35
  • 28 (a)
Cyp28d2 35
  • 28 (a)
Cyp6d2 35
  • 28 (a)
Cyp6t3 35
  • 27 (a)
Cyp6u1 35
  • 27 (a)
Cyp28a5 35
  • 26 (a)
Cyp28c1 35
  • 25 (a)
Cyp309a2 35
  • 25 (a)
Cyp313a2 35
  • 25 (a)
Cyp6t1 35
  • 25 (a)
Cyp309a1 35
  • 24 (a)
Cyp317a1 35
  • 24 (a)
worm
(Caenorhabditis elegans)
 Secernentea C36A4.1 35
  • 30 (a)
F14F7.2 35
  • 30 (a)
C36A4.2 35
  • 29 (a)
F14F7.3 35
  • 29 (a)
T10B9.5 35
  • 29 (a)
T10B9.7 35
  • 29 (a)
T10B9.8 35
  • 29 (a)
T10B9.1 35
  • 28 (a)
T10B9.2 35
  • 28 (a)
T10B9.3 35
  • 28 (a)
C36A4.6 35
  • 27 (a)
F42A6.4 35
  • 27 (a)
K06G5.2 35
  • 25 (a)
ZK1320.4 35
  • 25 (a)
rice
(Oryza sativa)
 Liliopsida Os02g0221900 33
  • 39.7 (n)
Species where no ortholog for CYP3A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A7 Gene

ENSEMBL:
Gene Tree for CYP3A7 (if available)
TreeFam:
Gene Tree for CYP3A7 (if available)

Paralogs for CYP3A7 Gene

Paralogs for CYP3A7 Gene

(10) SIMAP similar genes for CYP3A7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYP3A7: view

Variants for CYP3A7 Gene

Sequence variations from dbSNP and Humsavar for CYP3A7 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000189515 -- 99,723,701(-) A/T intron_variant
rs1000318792 -- 99,735,367(-) T/C upstream_transcript_variant
rs1000472813 -- 99,722,816(-) A/G intron_variant
rs1000781448 -- 99,716,579(-) G/C intron_variant
rs1000916923 -- 99,716,245(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A7 Gene

Variant ID Type Subtype PubMed ID
esv2734887 CNV deletion 23290073
esv29839 CNV loss 19812545
esv8941 CNV gain 19470904
nsv522107 CNV loss 19592680
nsv970911 CNV duplication 23825009

Variation tolerance for CYP3A7 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP3A7 Gene

Human Gene Mutation Database (HGMD)
CYP3A7
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A7 Gene

Disorders for CYP3A7 Gene

Additional Disease Information for CYP3A7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYP3A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A7 Gene

Publications for CYP3A7 Gene

  1. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 22 44 58
  2. Identification of a null allele of cytochrome P450 3A7: CYP3A7 polymorphism in a Korean population. (PMID: 19585271) Lee SS … Shin JG (Molecular biology reports 2010) 3 22 44 58
  3. Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. (PMID: 18445661) Goodarzi MO … Azziz R (The Journal of clinical endocrinology and metabolism 2008) 3 22 44 58
  4. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. (PMID: 18978522) Crettol S … Eap CB (Therapeutic drug monitoring 2008) 3 22 44 58
  5. Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. (PMID: 17559345) Du J … He L (Pharmacogenomics 2007) 3 22 44 58

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