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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP3A5 Gene

protein-coding GIFtS: 69
GCID: GC07M099246

cytochrome P450, family 3, subfamily A, polypeptide 5

(Previous names: cytochrome P450, subfamily IIIA (niphedipine oxidase),...)

Explore 71 diseases affiliated with
CYP3A5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 5¹ ²		CYPIIIA5² ³
P450PCN3¹ ² ⁵		EC 1.14.14.1³ ⁸
CP35¹ ²		Aryl Hydrocarbon Hydroxylase²
PCN3¹ ²		Cytochrome P450 3A5²
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5¹ ²		Flavoprotein-Linked Monooxygenase²
Cytochrome P450 HLp2² ³		Microsomal Monooxygenase²
Cytochrome P450-PCN3² ³		Xenobiotic Monooxygenase²

External Ids:	HGNC: 2638¹	Entrez Gene: 1577²	Ensembl: ENSG00000106258⁷	OMIM: 605325⁵	UniProtKB: P20815³

ORGUL members:
	NONCODE:n409408 n409411 n409412 n409413 n409409	see all 6

Export aliases for CYP3A5 gene to outside databases

Previous GC identifers: GC07M097780 GC07M098843 GC07M098857 GC07M098891 GC07M099083 GC07M093882

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP3A5:

This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and

some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid

hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on

chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has

caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple

alternatively spliced transcript variants have been identified for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP3A5

PharmGKB "VIP" summary for CYP3A5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP3A5 gene promoter:
C/EBPbeta ATF-2 POU3F1 Ik-3 PPAR-gamma1 Ik-2 POU2F1 POU2F1a PPAR-gamma2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP3A5 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP3A5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.1

CYP3A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A5 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M099246: view genomic region (about GC identifiers)

Start:	99,245,813 bp from pter	End:	99,277,621 bp from pter
Size:	31,809 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 98,605,608-98,637,429

ORGUL member locations:
Legend (see complete legend)

n409408
n409410
n409409
n409412
n409411
n409413

lncRNA
Full Legend

99245812 99261717 99277621 chr7

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815 (See protein sequence)

Recommended Name: Cytochrome P450 3A5

Size: 502 amino acids; 57109 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Miscellaneous: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets

of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2

different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to

CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664)

Secondary accessions: A4D289 B7Z5I7 Q53WY8 Q75MV0 Q9HB56

Alternative splicing: 2 isoforms: P20815-1 P20815-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP3A5: NX_P20815

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20815

4/15 DME Specific Peptides for CYP3A5 (P20815) (see all 15)

SVFTNRR

PGPTPLP

LFPFLTP

LLSPTFT

CYP3A5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000768.1 NP_001177413.1

ENSEMBL proteins:

ENSP00000222982 ENSP00000401269 ENSP00000415399 ENSP00000342969 ENSP00000343074

Reactome Protein details: P20815
Human Recombinant Protein Products:

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	Uscn Proteins for CYP3A5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0043231	intracellular membrane-bounded organelle	TAS	2732228

CYP3A5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP3A5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP3A5 for domains About GeneDecksing

4 InterPro domains/families:

IPR008072 Cyt_P450_E_CYP3A

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002402 Cyt_P450_E_grp-II

Graphical View of Domain Structure for InterPro Entry P20815

ProtoNet protein and cluster: P20815

3 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB002402 Group II E-class P450 signature

IPB008072 CYP3A P450 family signature

UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs,

pesticides, and carcinogens

Genatlas biochemistry entry for CYP3A5:

cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved in the

matabolism of sex hormones

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A5

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	ISS	--
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016491	oxidoreductase activity	IDA	15039299
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	--	--

CYP3A5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CYP3A5:

Decreased Salmonella enterica

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ifosfamide Pathway, Pharmacokinetics

Ifosfamide Pathway, Pharmacokinetics	1.00	Artemisinin and Derivatives Pathway, Pharmacokinetics	0.50
Cyclophosphamide Pathway, Pharmacokinetics	0.86	Clopidogrel Pathway, Pharmacokinetics	0.36
Nevirapine Pathway, Pharmacokinetics	0.50

Tamoxifen metabolism

Tamoxifen metabolism	1.00	Estradiol metabolism	0.52
Tamoxifen Pathway, Pharmacokinetics	0.68	Benzodiazepine Pathway, Pharmacokinetics	0.30
Estradiol metabolism	0.52

Estrone metabolism

	Estrone metabolism	1.00			Androstenedione and testosterone biosynthesis and metabolism p.1	0.57
	Estrone metabolism	1.00			Androstenedione and testosterone biosynthesis and metabolism p.1	0.57

Irinotecan Pathway, Pharmacokinetics

	Irinotecan Pathway, Pharmacokinetics	1.00			Mycophenolic acid Pathway, Pharmacokinetics	0.50
	Irinotecan Pathway	0.73			Taxane Pathway, Pharmacokinetics	0.30

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CYP3A5

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estradiol metabolism
	Retinol metabolism
	Estrone metabolism

4 GeneGo (Thomson Reuters) Pathways for CYP3A5

	Estradiol metabolism
	Retinol metabolism
	Estrone metabolism
	Androstenedione and testosterone biosynthesis and metabolism p.1

4 BioSystems Pathways for CYP3A5

	Irinotecan Pathway
	cytochrome P450
	Tamoxifen metabolism
	metapathway biotransformation

5 Reactome Pathways for CYP3A5

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

5/22 PharmGKB Pathways for CYP3A5 (see all 22)

	Artemisinin and Derivatives Pathway, Pharmacokinetics
	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Benzodiazepine Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Clopidogrel Pathway, Pharmacokinetics

5/7 Kegg Pathways (Kegg details for CYP3A5) (see all 7):

	Steroid hormone biosynthesis
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

CYP3A5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP3A5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/106 Interacting proteins for CYP3A5 (ENSP00000222982⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 106)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785
ALDH1A2	ENSP00000249750⁴	STRING: ENSP00000249750
ALOX15	ENSP00000293761⁴	STRING: ENSP00000293761
CES2	ENSP00000317842⁴	STRING: ENSP00000317842
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0008202	steroid metabolic process	TAS	2732228
GO:0009822	alkaloid catabolic process	IDA	15039299
GO:0042737	drug catabolic process	IDA	15039299
GO:0044281	small molecule metabolic process	TAS	--

CYP3A5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP3A5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP3A5

10/52 HMDB Compounds for CYP3A5 (see all 52) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

10/152 DrugBank Compounds for CYP3A5 (see all 152) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alfentanil	Alfentanilum [INN-Latin] (see all 2)	71195-58-9	enzyme	substrate	17554244 19934256 15557344 15731592
Midazolam	Dea No. 2884 (see all 4)	59467-70-8	enzyme	substrate	12814972 7826796 19934256 11996015
Atorvastatin	--	134523-00-5	enzyme	substrate	11038166 19934256 19515014
Ifosfamide	Asta Z 4942 (see all 10)	3778-73-2	enzyme	substrate	16702183 19515014 10348794
Saxagliptin	BMS-477118 (see all 2)	361442-04-8	enzyme	substrate	21332626 21651615 20690781
Alprazolam	--	28981-97-7	enzyme	substrate	19934256 19515014
Clopidogrel	--	113665-84-2	enzyme	substrate	19934256 19515014
Dasatinib	--	302962-49-8	enzyme	substrate	18556438 19733976
Diazepam	--	439-14-5	enzyme	substrate	19934256 19515014
Erlotinib	--	183321-74-6	enzyme	substrate	17575239 19733976

10/63 Novoseek chemical compound relationships for CYP3A5 gene (see all 63) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
n-phenylpropionamide	80.8	5	15731592 (2), 15557344 (1)
noralfentanil	79.8	5	15731592 (2), 15557344 (1)
tacrolimus	77.1	163	16424824 (7), 15951320 (7), 16249748 (6), 18334918 (5) (see all 47)
ibrolipim	74.5	1	15681896 (1)
midazolam	70.6	32	12433824 (3), 16243813 (3), 17554244 (3), 16638818 (2) (see all 14)
4-hydroxymidazolam	66.8	2	8185679 (2)
1-hydroxymidazolam	65.3	4	12433824 (2), 8185679 (2)
paliperidone	63.3	2	18708991 (2)
carebastine	62.1	1	16896065 (1)
ketoconazole	61.3	3	9929500 (1), 15731592 (1), 15557344 (1)

6 PharmGKB related drug/compound annotations for CYP3A5 gene

Drug/compound	PharmGKB Annotation
cyclosporine	CA
efavirenz	CA
nevirapine	CA
paclitaxel	CA
sirolimus	CA
tacrolimus	CA DG

About this table

Search CenterWatch for drugs/clinical trials and news about CYP3A5 / CP3A5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP3A5 gene (2 alternative transcripts):

NM_000777.3 NM_001190484.1

Unigene Cluster for CYP3A5:

Cytochrome P450, family 3, subfamily A, polypeptide 5

Hs.571258 [show with all ESTs]

Unigene Representative Sequence: BX537676

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000222982(uc003urq.3 uc003urs.3 uc010lgg.3) ENST00000469887

ENST00000461920 ENST00000488187 ENST00000473347 ENST00000463364 ENST00000481825

ENST00000466061 ENST00000480723 ENST00000463907 ENST00000439761(uc003urt.3)

ENST00000469622 ENST00000456417 ENST00000489231 ENST00000343703 ENST00000339843(uc003urr.3 uc011kiy.2)

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Additional cDNA sequence:

AF355801.1 AF355804.1 AJ563378.1 AJ563379.1 AK223008.1 AK296205.1 AK299002.1 AK309166.1

AK313813.1 BC022298.1 BC025176.1 BC026255.1 BC033862.1 BX537676.1 BX648856.1 J04813.1

L26985.1 NR_033807.1 NR_033808.1 NR_033809.1 NR_033810.1 NR_033811.1 NR_033812.1 X90579.1

23 DOTS entries:

DT.313245 DT.91751640 DT.121068158 DT.313246 DT.75139376 DT.100840559 DT.101982961 DT.100792127

DT.95261830 DT.99974859 DT.95259273 DT.100792126 DT.102845494 DT.121068268 DT.91828403 DT.95096728

DT.99943618 DT.100643862 DT.100775926 DT.121068247 DT.40191552 DT.86855768 DT.95197631

24/152 AceView cDNA sequences (see all 152):

AV656839 T40062 AA076026 CB164323 CK823630 BQ129416 BX097094 CR620792

BC025176 AF355801 AV646431 BM850407 AI678780 AV651366 AV720071 AK097322

AF355804 AI970079 AV646168 J04813 CA775883 BX648856 AV657140 AF355802

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP3A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See CYP3A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP3A5

SOURCE GeneReport for Unigene cluster: Hs.571258

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP3A5:

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CYP3A5 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NT18_CHICK⁶	cytochrome P450 A 37	58(a)	1 → many	14(3939211-3948991)
lizard (Anolis carolinensis)	Reptilia	--	--	54(a)	1 → many	GL343987.1(114011-127496)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19450²	Transcribed sequence with weak similarity to protein more	76.12(n)		BX779027.1
zebrafish (Danio rerio)	Actinopterygii	Dr.25208²	Transcribed sequence with weak similarity to protein more	73.69(n)		CF999879.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp6a17³ Cyp9c1¹	cytochrome P450³ Cytochrome P450-9c1¹	34(a) (best of 36)³ 46.68(n)¹ 35.48(a)¹		51D1³ 37941¹ NM_079126.2¹ NP_523850.1¹
worm (Caenorhabditis elegans)	Secernentea	T10B9.1³ cyp-13A11¹	cytochrome P450³ Protein CYP-13A11¹	32(a) (best of 15)³ 47.59(n)¹ 36.17(a)¹		II(9795758-9797650)³ 184472¹ NM_067303.1¹ NP_499704.1¹

ENSEMBL Gene Tree for CYP3A5 (if available)
TreeFam Gene Tree for CYP3A5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP3A5 gene

CYP4F22² CYP4F3² CYP4F2² CYP4F11² CYP46A1² ENSG00000225607² CYP4B1² CYP4X1²

TBXAS1² CYP3A4² CYP3A43² CYP3A7² CYP4V2² CYP4A22² CYP4A11² CYP4F12²

CYP4Z1²

18/28 SIMAP similar genes for CYP3A5 using alignment to 9 protein entries: CP3A5_HUMAN (see all proteins) (see all similar genes):

DKFZp686I18188 CYP3A43/CYP3A4 CYP3A4 CYP3A7 CYP3A43 KLKB1

CYP4V2 TBXAS1 CYP27C1 CYP4B1 CYP24 CYP4F2

CYP11B1 CYP4F3 CYP46A1 CYP4F12 CYP2E1 thromboxane synthase

CYP3A5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57922842^1,2	C,F,	--	98605159(+)	`ACAAAG/AGCCCC`	4	--	ds500¹		1	WA	118
rs76871422^1,2	F,	--	98605168(+)	`CCACAC/ACAACA`	4	--	ds500¹		1	NA	120
rs41303967^1,2	C,	--	98605659(-)	`ATTTCA/GACTTA`	4	--	nc-transcript-variantut3¹		5	NS	186
rs17161788^1,2	C,F,H	--	98605704(+)	`CAAAGT/CAGAAA`	4	--	ut3¹ nc-transcript-variantese³		7	NA NS EA	422
rs13233803^1,2	C,H	--	98605748(+)	`CATCTC/GTTGAA`	5	T R	nc-transcript-variantmis¹ ese³		5	NS EA NA	422
rs28365076^1,2	C,F,H,	--	98606283(-)	`GGAAGA/C/G/T GTTAC`	4	--	int¹		12	NS WA	1854
rs41303964^1,2	C,	--	98606435(-)	`GACAAT/CAGTGC`	4	--	int¹		5	NS	188
rs28365075^1,2	C,	--	98606502(-)	`CTCACT/AGAACT`	4	--	int¹		8	NS NA	502
rs10249369^1,2	C,F,H,	--	98606787(+)	`AGGCTA/GTTGCT`	4	--	int¹		21	NS EA NA CSA WA	2361
rs28365088^1,2	C,	--	98606924(-)	`CTGGTG/AGATAT`	4	--	int¹		8	NS NA	500

HapMap Linkage Disequilibrium report for CYP3A5 (99245813 - 99277621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYP3A5
1 CNV: 100053
Human Gene Mutation Database (HGMD): CYP3A5

Locus Specific Mutation Databases (LSDB): CYP3A5

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP3A5 for disorders           About GeneDecksing

OMIM gene information: 605325
OMIM disorders: 145500
20/71 diseases for CYP3A5 (see all 71):    About MalaCards

hypertension, salt-sensitive essential antley-bixler syndrome human immunodeficiency virus infectious disease warfarin sensitivity

cholesterol tardive dyskinesia testicular germ cell cancer primary biliary cirrhosis

squamous cell carcinoma laryngeal squamous cell carcinoma toxic encephalopathy myocardial infarction

acute myocardial infarction lymphoblastic leukemia esophageal squamous cell carcinoma peripheral t-cell lymphoma

gilbert syndrome acute lymphoblastic leukemia chronic myeloid leukemia germ cell cancer

1 disease from the University of Copenhagen DISEASES database for CYP3A5:

Oral submucous fibrosis

10/12 Novoseek disease relationships for CYP3A5 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	13.5	9	15876487 (2), 17914095 (2), 18566991 (1), 17116727 (1) (see all 5)
breast cancer	10.3	10	15596297 (2), 19332043 (2), 15632378 (1), 17244352 (1) (see all 8)
cancer lung	5.38	1	14515059 (1)
lymphoblastic leukemia acute	4.34	1	12969965 (1)
neutropenia	3.18	1	19696793 (1)
adenocarcinoma lung	1.58	2	15698577 (1), 12538830 (1)
tumors	0.497	9	15596297 (3), 18566991 (1), 8869826 (1), 16281975 (1) (see all 6)
leukemia	0	2	15312409 (1), 19650988 (1)
inflammation	0	1	18566991 (1)
adenoma	0	7	16281975 (5), 17363580 (1)

Genetic Association Database (GAD): CYP3A5
Human Genome Epidemiology (HuGE) Navigator: CYP3A5 (428 documents)

Export disorders for CYP3A5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP3A5 gene, integrated from 9 sources (see all 674):
(articles sorted by number of sources associating them with CYP3A5)

Utopia: connect your pdf to the dynamic
world of online information

Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PubMed id 11502729)^{1, 2, 4, 9} Chou F.C.... Huang J.D. (2001)
Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. (PubMed id 12893984)^{1, 2, 4} Lee S.J.... Goldstein J.A. (2003)
Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. (PubMed id 15454734)^{1, 4, 9} Wojnowski L....Wild C.P. (2004)
Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PubMed id 17554244)^{1, 7, 9} Kharasch E.D....Ensign D. (2007)
Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients. (PubMed id 15502717)^{1, 4, 9} Tsuchiya N....Kato T. (2004)
Genotyping cytochrome P450 3A5 using the Light Cycler. (PubMed id 16168193)^{1, 4, 9} Fredericks S....Holt D.W. (2005)
The genetic determinants of the CYP3A5 polymorphism. (PubMed id 11740341)^{1, 4, 9} Hustert E....Wojnowski L. (2001)
[Study on polymorphisms of CYP3A5 gene and their clinical role] (PubMed id 16086282)^{1, 4, 9} Wang H.P....Mao P. (2005)
CYP3A5 phenotype-genotype correlations in a British population. (PubMed id 12814460)^{1, 4, 9} King B.P....Daly A.K. (2003)
CYP3A5 variant allele frequencies in Dutch Caucasians. (PubMed id 12324482)^{1, 4, 9} van Schaik R.H....Lindemans J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1577	HGNC: 2638	AceView: CYP3A5	Ensembl:ENSG00000106258	euGenes: HUgn1577
ECgene: CYP3A5	Kegg: 1577	H-InvDB: CYP3A5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP3A5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP3A5	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp3a5.htm

Intellectual Property for CYP3A5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP3A5 gene:
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GeneCards and IP:
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cytochrome P450, family 3, subfamily A, polypeptide 5

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CYP3A5 Gene

cytochrome P450, family 3, subfamily A, polypeptide 5

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