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Aliases for CYP3A5 Gene

Aliases for CYP3A5 Gene

  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 2 3
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 2 3
  • Cytochrome P450 HLp2 3 4
  • Cytochrome P450-PCN3 3 4
  • EC 1.14.14.1 4 63
  • P450PCN3 3 6
  • CYPIIIA5 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 3A5 3
  • PCN3 3
  • CP35 3

External Ids for CYP3A5 Gene

Previous GeneCards Identifiers for CYP3A5 Gene

  • GC07M097780
  • GC07M098843
  • GC07M098857
  • GC07M098891
  • GC07M099083
  • GC07M099246
  • GC07M093882

Summaries for CYP3A5 Gene

Entrez Gene Summary for CYP3A5 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP3A5 Gene

CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5) is a Protein Coding gene. Diseases associated with CYP3A5 include tacrolimus dose selection and engraftment syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP3A5 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP3A5 Gene

PharmGKB "VIP" Summary for CYP3A5 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A5 Gene

Genomics for CYP3A5 Gene

Regulatory Elements for CYP3A5 Gene

Genomic Location for CYP3A5 Gene

Start:
99,648,190 bp from pter
End:
99,679,998 bp from pter
Size:
31,809 bases
Orientation:
Minus strand

Genomic View for CYP3A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP3A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A5 Gene

Proteins for CYP3A5 Gene

  • Protein details for CYP3A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20815-CP3A5_HUMAN
    Recommended name:
    Cytochrome P450 3A5
    Protein Accession:
    P20815
    Secondary Accessions:
    • A4D289
    • B7Z5I7
    • Q53WY8
    • Q75MV0
    • Q9HB56

    Protein attributes for CYP3A5 Gene

    Size:
    502 amino acids
    Molecular mass:
    57109 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Alternative splice isoforms for CYP3A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A5 Gene

Proteomics data for CYP3A5 Gene at MOPED

Post-translational modifications for CYP3A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A5 Gene

Domains for CYP3A5 Gene

Gene Families for CYP3A5 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P20815

UniProtKB/Swiss-Prot:

CP3A5_HUMAN :
  • P20815
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A5: view

Function for CYP3A5 Gene

Molecular function for CYP3A5 Gene

GENATLAS Biochemistry: cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved in the matabolism of sex hormones
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP3A5 Gene

Gene Ontology (GO) - Molecular Function for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IDA 15039299
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0019825 oxygen binding TAS 2732228
genes like me logo Genes that share ontologies with CYP3A5: view

Phenotypes for CYP3A5 Gene

genes like me logo Genes that share phenotypes with CYP3A5: view

miRNA for CYP3A5 Gene

miRTarBase miRNAs that target CYP3A5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP3A5 Gene

Localization for CYP3A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A5 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP3A5 Gene COMPARTMENTS Subcellular localization image for CYP3A5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle TAS 2732228
genes like me logo Genes that share ontologies with CYP3A5: view

Pathways for CYP3A5 Gene

genes like me logo Genes that share pathways with CYP3A5: view

Interacting Proteins for CYP3A5 Gene

Gene Ontology (GO) - Biological Process for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process TAS 2732228
GO:0009822 alkaloid catabolic process IDA 15039299
GO:0042737 drug catabolic process IDA 15039299
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CYP3A5: view

Compounds for CYP3A5 Gene

(52) HMDB Compounds for CYP3A5 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(167) Drugbank Compounds for CYP3A5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
ado-trastuzumab emtansine
  • RG-3502
1018448-65- enzyme substrate
Alfentanil
  • Alfentanilum [INN-Latin]
71195-58-9 enzyme substrate
Alprazolam
28981-97-7 enzyme substrate
Amiodarone
  • Amiodarona [INN-Spanish]
1951-25-3 enzyme inhibitor
Amitriptyline
  • Amitriprolidine
50-48-6 enzyme substrate

(63) Novoseek inferred chemical compound relationships for CYP3A5 Gene

Compound -log(P) Hits PubMed IDs
n-phenylpropionamide 80.8 3
noralfentanil 79.8 3
tacrolimus 77.1 120
ibrolipim 74.5 1
midazolam 70.6 24
genes like me logo Genes that share compounds with CYP3A5: view

Transcripts for CYP3A5 Gene

Unigene Clusters for CYP3A5 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A5 Gene

No ASD Table

Relevant External Links for CYP3A5 Gene

GeneLoc Exon Structure for
CYP3A5
ECgene alternative splicing isoforms for
CYP3A5

Expression for CYP3A5 Gene

mRNA expression in normal human tissues for CYP3A5 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A5 Gene

This gene is overexpressed in Liver (19.3) and Small Intestine - Terminal Ileum (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP3A5 Gene

SOURCE GeneReport for Unigene cluster for CYP3A5 Gene Hs.571258

genes like me logo Genes that share expressions with CYP3A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CYP3A5 Gene

Orthologs for CYP3A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A5 35
  • 99.67 (n)
  • 99.4 (a)
CYP3A5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
ManyToMany
CYP3A5 36
  • 73 (a)
ManyToMany
CYP3A5 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
CYP3A12 36
  • 79 (a)
ManyToMany
CYP3A26 36
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 35
  • 78.24 (n)
  • 73.25 (a)
Cyp3a11 36
  • 73 (a)
ManyToMany
Cyp3a13 36
  • 74 (a)
ManyToMany
Cyp3a16 36
  • 70 (a)
ManyToMany
Cyp3a25 36
  • 71 (a)
ManyToMany
Cyp3a41a 16
Cyp3a41a 36
  • 72 (a)
ManyToMany
Cyp3a41b 36
  • 72 (a)
ManyToMany
Cyp3a44 36
  • 70 (a)
ManyToMany
Cyp3a57 36
  • 68 (a)
ManyToMany
Cyp3a59 36
  • 69 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100910877 35
  • 77.62 (n)
  • 72.34 (a)
chicken
(Gallus gallus)
Aves CYP3A37 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19450 35
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 36
  • 51 (a)
ManyToMany
cyp3c1 36
  • 48 (a)
ManyToMany
cyp3c1l2 36
  • 49 (a)
ManyToMany
cyp3c4 36
  • 49 (a)
ManyToMany
Dr.25208 35
si:dkey-21n8.3 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp9c1 35
  • 46.49 (n)
  • 35.41 (a)
Cyp6a17 37
  • 34 (a)
Cyp6d2 37
  • 28 (a)
Cyp9b1 37
  • 29 (a)
Cyp313a2 37
  • 26 (a)
Cyp6a2 37
  • 32 (a)
Cyp6g1 37
  • 32 (a)
Cyp317a1 37
  • 27 (a)
Cyp6a21 37
  • 30 (a)
Cyp28d2 37
  • 28 (a)
Cyp6a9 37
  • 32 (a)
Cyp6t3 37
  • 28 (a)
Cyp6w1 37
  • 29 (a)
Cyp28a5 37
  • 25 (a)
Cyp313a1 37
  • 27 (a)
Cyp6a19 37
  • 32 (a)
Cyp6d5 37
  • 30 (a)
Cyp9f2 37
  • 32 (a)
Cyp9c1 37
  • 32 (a)
Cyp309a2 37
  • 26 (a)
Cyp6t1 37
  • 24 (a)
Cyp9h1 37
  • 30 (a)
Cyp6a23 37
  • 34 (a)
Cyp6a8 37
  • 30 (a)
Cyp6a13 37
  • 32 (a)
Cyp6v1 37
  • 33 (a)
Cyp9b2 37
  • 31 (a)
Cyp28d1 37
  • 28 (a)
Cyp6a14 37
  • 32 (a)
Cyp309a1 37
  • 25 (a)
Cyp6g2 37
  • 29 (a)
Cyp6a18 37
  • 31 (a)
Cyp6d4 37
  • 31 (a)
Cyp6a20 37
  • 31 (a)
Cyp6u1 37
  • 26 (a)
Cyp28c1 37
  • 26 (a)
Cyp6a22 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea T10B9.8 37
  • 30 (a)
K06G5.2 37
  • 26 (a)
ccp-44 37
  • 25 (a)
T10B9.1 37
  • 32 (a)
T10B9.5 37
  • 29 (a)
F14F7.2 37
  • 32 (a)
F42A6.4 37
  • 28 (a)
C36A4.1 37
  • 29 (a)
ZK1320.4 37
  • 27 (a)
T10B9.2 37
  • 31 (a)
F14F7.3 37
  • 31 (a)
T10B9.7 37
  • 29 (a)
T10B9.3 37
  • 28 (a)
C36A4.6 37
  • 28 (a)
C36A4.2 37
  • 29 (a)
Species with no ortholog for CYP3A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A5 Gene

ENSEMBL:
Gene Tree for CYP3A5 (if available)
TreeFam:
Gene Tree for CYP3A5 (if available)

Paralogs for CYP3A5 Gene

genes like me logo Genes that share paralogs with CYP3A5: view

Variants for CYP3A5 Gene

Sequence variations from dbSNP and Humsavar for CYP3A5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs776741 -- 99,681,513(-) catct(C/T)acccc upstream-variant-2KB
rs3823812 -- 99,680,691(-) TCTAT(A/C/T)GCTAT upstream-variant-2KB
rs4646441 -- 99,679,915(-) CACAG(C/T)TGAAG utr-variant-5-prime, nc-transcript-variant
rs4646442 -- 99,678,870(-) CTCCA(-/A)CCTGT intron-variant
rs4646443 -- 99,678,700(-) TTGAT(A/G)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A5 Gene

Variant ID Type Subtype PubMed ID
nsv5865 CNV Insertion 18451855
esv2619613 CNV Insertion 19546169

Relevant External Links for CYP3A5 Gene

HapMap Linkage Disequilibrium report
CYP3A5
Human Gene Mutation Database (HGMD)
CYP3A5
Locus Specific Mutation Databases (LSDB)
CYP3A5
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A5 Gene

Disorders for CYP3A5 Gene

(1) OMIM Diseases for CYP3A5 Gene (605325)

(1) University of Copenhagen DISEASES for CYP3A5 Gene

(12) Novoseek inferred disease relationships for CYP3A5 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 13.5 7
breast cancer 10.3 10
cancer lung 5.38 1
lymphoblastic leukemia acute 4.34 1
neutropenia 3.18 1

Relevant External Links for CYP3A5

Genetic Association Database (GAD)
CYP3A5
Human Genome Epidemiology (HuGE) Navigator
CYP3A5
genes like me logo Genes that share disorders with CYP3A5: view

No data available for UniProtKB/Swiss-Prot for CYP3A5 Gene

Publications for CYP3A5 Gene

  1. Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PMID: 11502729) Chou F.C. … Huang J.D. (Drug Metab. Dispos. 2001) 3 4 23 48
  2. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PMID: 17554244) Kharasch E.D. … Ensign D. (Clin. Pharmacol. Ther. 2007) 3 23 25 48
  3. Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. (PMID: 18496131) Ekhart C. … Huitema A.D. (Pharmacogenet. Genomics 2008) 3 23 25 48
  4. CYP3A5 variant allele frequencies in Dutch Caucasians. (PMID: 12324482) van Schaik R.H. … Lindemans J. (Clin. Chem. 2002) 3 23 48
  5. Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes. (PMID: 12433824) Shih P.S. … Huang J.D. (Drug Metab. Dispos. 2002) 3 23 48

Products for CYP3A5 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP3A5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP3A5
    • Block miRNA regulation of CYP3A5 using miScript Target Protectors

    Sources for CYP3A5 Gene

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