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Aliases for CYP3A5 Gene

Aliases for CYP3A5 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 5 2 3 5
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 2 3
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 2 3
  • Cytochrome P450 HLp2 3 4
  • Cytochrome P450-PCN3 3 4
  • EC 1.14.14.1 4 63
  • CYPIIIA5 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • P450PCN3 3
  • CP35 3
  • PCN3 3

External Ids for CYP3A5 Gene

Previous GeneCards Identifiers for CYP3A5 Gene

  • GC07M097780
  • GC07M098843
  • GC07M098857
  • GC07M098891
  • GC07M099083
  • GC07M099246
  • GC07M093882

Summaries for CYP3A5 Gene

Entrez Gene Summary for CYP3A5 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP3A5 Gene

CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Cyp3a5-Related Altered Drug Metabolism. Among its related pathways are Aflatoxin activation and detoxification and Phenytoin Pathway, Pharmacokinetics. GO annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP3A5 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP3A5 Gene

PharmGKB "VIP" Summary for CYP3A5 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A5 Gene

Genomics for CYP3A5 Gene

Regulatory Elements for CYP3A5 Gene

Enhancers for CYP3A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP3A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP3A5 Gene

Chromosome:
7
Start:
99,648,189 bp from pter
End:
99,680,026 bp from pter
Size:
31,838 bases
Orientation:
Minus strand

Genomic View for CYP3A5 Gene

Genes around CYP3A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A5 Gene

Proteins for CYP3A5 Gene

  • Protein details for CYP3A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20815-CP3A5_HUMAN
    Recommended name:
    Cytochrome P450 3A5
    Protein Accession:
    P20815
    Secondary Accessions:
    • A4D289
    • B7Z5I7
    • Q53WY8
    • Q75MV0
    • Q9HB56

    Protein attributes for CYP3A5 Gene

    Size:
    502 amino acids
    Molecular mass:
    57109 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Alternative splice isoforms for CYP3A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A5 Gene

Proteomics data for CYP3A5 Gene at MOPED

Post-translational modifications for CYP3A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A5 Gene

Domains & Families for CYP3A5 Gene

Gene Families for CYP3A5 Gene

Graphical View of Domain Structure for InterPro Entry

P20815

UniProtKB/Swiss-Prot:

CP3A5_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A5: view

Function for CYP3A5 Gene

Molecular function for CYP3A5 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved in the matabolism of sex hormones
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A5 Gene

Gene Ontology (GO) - Molecular Function for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019825 oxygen binding TAS --
genes like me logo Genes that share ontologies with CYP3A5: view
genes like me logo Genes that share phenotypes with CYP3A5: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP3A5 Gene

Localization for CYP3A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A5 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP3A5 Gene COMPARTMENTS Subcellular localization image for CYP3A5 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CYP3A5 Gene

Pathways & Interactions for CYP3A5 Gene

genes like me logo Genes that share pathways with CYP3A5: view

Interacting Proteins for CYP3A5 Gene

Gene Ontology (GO) - Biological Process for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CYP3A5: view

No data available for SIGNOR curated interactions for CYP3A5 Gene

Drugs & Compounds for CYP3A5 Gene

(319) Drugs for CYP3A5 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Midazolam Approved, Illicit Pharma Enzyme, substrate 651
Tacrolimus Approved, Investigational Pharma Enzyme, substrate 1045
Cilostazol Approved Pharma Enzyme, substrate PDE3 inhibitor, PDE3A inhibitor. Also adenosine uptake inhibitor 101
Docetaxel Approved May 1996, Investigational Pharma Enzyme, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Carbamazepine Approved, Investigational Pharma Enzyme, inducer 128

(51) Additional Compounds for CYP3A5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate

(1) ApexBio Compounds for CYP3A5 Gene

Compound Action Cas Number
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
genes like me logo Genes that share compounds with CYP3A5: view

Transcripts for CYP3A5 Gene

Unigene Clusters for CYP3A5 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A5 Gene

No ASD Table

Relevant External Links for CYP3A5 Gene

GeneLoc Exon Structure for
CYP3A5
ECgene alternative splicing isoforms for
CYP3A5

Expression for CYP3A5 Gene

mRNA expression in normal human tissues for CYP3A5 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A5 Gene

This gene is overexpressed in Liver (x19.3) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for CYP3A5 Gene

This gene is overexpressed in Gallbladder (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A5 Gene



SOURCE GeneReport for Unigene cluster for CYP3A5 Gene Hs.571258

genes like me logo Genes that share expression patterns with CYP3A5: view

Protein tissue co-expression partners for CYP3A5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CYP3A5 Gene

Orthologs for CYP3A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp3a11 35
  • 78.24 (n)
  • 73.25 (a)
Cyp3a44 16
Cyp3a11 36
  • 73 (a)
ManyToMany
Cyp3a13 36
  • 74 (a)
ManyToMany
Cyp3a16 36
  • 70 (a)
ManyToMany
Cyp3a25 36
  • 71 (a)
ManyToMany
Cyp3a41a 36
  • 72 (a)
ManyToMany
Cyp3a41b 36
  • 72 (a)
ManyToMany
Cyp3a44 36
  • 70 (a)
ManyToMany
Cyp3a57 36
  • 68 (a)
ManyToMany
Cyp3a59 36
  • 69 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CYP3A5 35
  • 99.67 (n)
  • 99.4 (a)
CYP3A5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910877 35
  • 77.62 (n)
  • 72.34 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
ManyToMany
CYP3A5 36
  • 73 (a)
ManyToMany
CYP3A5 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
CYP3A12 36
  • 79 (a)
ManyToMany
CYP3A26 36
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A37 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19450 35
zebrafish
(Danio rerio)
Actinopterygii Dr.25208 35
cyp3a65 36
  • 51 (a)
ManyToMany
cyp3c1 36
  • 48 (a)
ManyToMany
cyp3c1l2 36
  • 49 (a)
ManyToMany
cyp3c4 36
  • 49 (a)
ManyToMany
si:dkey-21n8.3 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp28a5 37
  • 25 (a)
Cyp28c1 37
  • 26 (a)
Cyp28d1 37
  • 28 (a)
Cyp28d2 37
  • 28 (a)
Cyp309a1 37
  • 25 (a)
Cyp309a2 37
  • 26 (a)
Cyp313a1 37
  • 27 (a)
Cyp313a2 37
  • 26 (a)
Cyp317a1 37
  • 27 (a)
Cyp6a13 37
  • 32 (a)
Cyp6a14 37
  • 32 (a)
Cyp6a17 37
  • 34 (a)
Cyp6a18 37
  • 31 (a)
Cyp6a19 37
  • 32 (a)
Cyp6a2 37
  • 32 (a)
Cyp6a20 37
  • 31 (a)
Cyp6a21 37
  • 30 (a)
Cyp6a22 37
  • 31 (a)
Cyp6a23 37
  • 34 (a)
Cyp6a8 37
  • 30 (a)
Cyp6a9 37
  • 32 (a)
Cyp6d2 37
  • 28 (a)
Cyp6d4 37
  • 31 (a)
Cyp6d5 37
  • 30 (a)
Cyp6g1 37
  • 32 (a)
Cyp6g2 37
  • 29 (a)
Cyp6t1 37
  • 24 (a)
Cyp6t3 37
  • 28 (a)
Cyp6u1 37
  • 26 (a)
Cyp6v1 37
  • 33 (a)
Cyp6w1 37
  • 29 (a)
Cyp9b1 37
  • 29 (a)
Cyp9b2 37
  • 31 (a)
Cyp9c1 37
  • 32 (a)
Cyp9f2 37
  • 32 (a)
Cyp9h1 37
  • 30 (a)
Cyp9c1 35
  • 46.49 (n)
  • 35.41 (a)
worm
(Caenorhabditis elegans)
Secernentea C36A4.1 37
  • 29 (a)
C36A4.2 37
  • 29 (a)
C36A4.6 37
  • 28 (a)
ccp-44 37
  • 25 (a)
F14F7.2 37
  • 32 (a)
F14F7.3 37
  • 31 (a)
F42A6.4 37
  • 28 (a)
K06G5.2 37
  • 26 (a)
T10B9.1 37
  • 32 (a)
T10B9.2 37
  • 31 (a)
T10B9.3 37
  • 28 (a)
T10B9.5 37
  • 29 (a)
T10B9.7 37
  • 29 (a)
T10B9.8 37
  • 30 (a)
ZK1320.4 37
  • 27 (a)
Species with no ortholog for CYP3A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A5 Gene

ENSEMBL:
Gene Tree for CYP3A5 (if available)
TreeFam:
Gene Tree for CYP3A5 (if available)

Paralogs for CYP3A5 Gene

genes like me logo Genes that share paralogs with CYP3A5: view

Variants for CYP3A5 Gene

Sequence variations from dbSNP and Humsavar for CYP3A5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_008365 -
VAR_024728 -
VAR_024729 -
VAR_024730 -
VAR_024731 -

Structural Variations from Database of Genomic Variants (DGV) for CYP3A5 Gene

Variant ID Type Subtype PubMed ID
nsv5865 CNV Insertion 18451855
esv2619613 CNV Insertion 19546169

Variation tolerance for CYP3A5 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP3A5 Gene

Human Gene Mutation Database (HGMD)
CYP3A5
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A5 Gene

Disorders for CYP3A5 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CYP3A5 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertension, essential
  • hypertension, essential 3
cyp3a5-related altered drug metabolism
tacrolimus dose selection
engraftment syndrome
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP3A5

Genetic Association Database (GAD)
CYP3A5
Human Genome Epidemiology (HuGE) Navigator
CYP3A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A5
genes like me logo Genes that share disorders with CYP3A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP3A5 Gene

Publications for CYP3A5 Gene

  1. Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PMID: 11502729) Chou F.C. … Huang J.D. (Drug Metab. Dispos. 2001) 3 4 23 48 67
  2. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PMID: 17554244) Kharasch E.D. … Ensign D. (Clin. Pharmacol. Ther. 2007) 3 23 25 26
  3. Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. (PMID: 18496131) Ekhart C. … Huitema A.D. (Pharmacogenet. Genomics 2008) 3 23 25
  4. The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. (PMID: 18308836) Ku H.Y. … Liu K.H. (Drug Metab. Dispos. 2008) 23 25 26
  5. Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. (PMID: 15557344) Klees T.M. … Kharasch E.D. (Drug Metab. Dispos. 2005) 23 25 26

Products for CYP3A5 Gene

Sources for CYP3A5 Gene

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