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CYP3A5 Gene

protein-coding   GIFtS: 69
GCID: GC07M099246

Cytochrome P450, Family 3, Subfamily A, Polypeptide 5

(Previous names: cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide...)
  See CYP3A5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 51 2     CP352
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 51 2     PCN32
Cytochrome P450 HLp22 3     Aryl Hydrocarbon Hydroxylase2
Cytochrome P450-PCN32 3     Cytochrome P450 3A52
CYPIIIA52 3     Flavoprotein-Linked Monooxygenase2
EC 1.14.14.13 8     Microsomal Monooxygenase2
P450PCN32 5     Xenobiotic Monooxygenase2

External Ids:    HGNC: 26381   Entrez Gene: 15772   Ensembl: ENSG000001062587   OMIM: 6053255   UniProtKB: P208153   

Export aliases for CYP3A5 gene to outside databases

Previous GC identifers: GC07M097780 GC07M098843 GC07M098857 GC07M098891 GC07M099083 GC07M093882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP3A5 Gene:
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine
as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of
cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar
to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene
or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
(provided by RefSeq, Jun 2010)

GeneCards Summary for CYP3A5 Gene:
CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) is a protein-coding gene. Diseases associated with CYP3A5 include engraftment syndrome, and hypertension, essential, salt-sensitive. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP3A5 Gene

PharmGKB "VIP" summary for CYP3A5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP3A5 gene promoter:
         C/EBPbeta   ATF-2   POU3F1   Ik-3   PPAR-gamma1   Ik-2   POU2F1   POU2F1a   PPAR-gamma2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP3A5 promoter sequence
   Search Chromatin IP Primers for CYP3A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.1

CYP3A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099246:  view genomic region     (about GC identifiers)

Start:
99,245,813 bp from pter      End:
99,277,621 bp from pter
Size:
31,809 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,605,608-98,637,429     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CYP3A5

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815 (See protein sequence)
Recommended Name: Cytochrome P450 3A5  
Size: 502 amino acids; 57109 Da
Cofactor: Heme group (By similarity)
Miscellaneous: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct
sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts
exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined
in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver
(PubMed:11726664)
Secondary accessions: A4D289 B7Z5I7 Q53WY8 Q75MV0 Q9HB56
Alternative splicing: 2 isoforms:  P20815-1   P20815-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP3A5: NX_P20815

Explore proteomics data for CYP3A5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP3A5 (P20815) (see all 15)
     SVFTNRR  PGPTPLP  LFPFLTP  LLSPTFT 


    See CYP3A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000768.1  NP_001177413.1  

    ENSEMBL proteins: 
     ENSP00000222982   ENSP00000401269   ENSP00000415399   ENSP00000342969   ENSP00000343074  
    Reactome Protein details: P20815

    CYP3A5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A5
    CYP3 family

    4 InterPro protein domains:
     IPR008072 Cyt_P450_E_CYP3A
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002402 Cyt_P450_E_grp-II

    Graphical View of Domain Structure for InterPro Entry P20815

    ProtoNet protein and cluster: P20815

    3 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB002402 Group II E-class P450 signature
    IPB008072 CYP3A P450 family signature


    UniProtKB/Swiss-Prot: CP3A5_HUMAN, P20815
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP3A5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP3A5_HUMAN, P20815
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including
    drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP3A5:
    cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved
    in the matabolism of sex hormones

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ISS--
    GO:0005506iron ion binding IEA--
    GO:0016491oxidoreductase activity IDA15039299
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ----
         
    Find genes that share ontologies with CYP3A5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CYP3A5:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-mir-335-5p (MIRT017425)

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    GenScript: all cDNA clones in your preferred vector (see all 2): CYP3A5 (NM_000777)
    Sino Biological Human cDNA Clone for CYP3A5
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP3A5_HUMAN, P20815: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle TAS2732228

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP3A5 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Estradiol metabolism0.00
    metapathway biotransformation0.42
    Phenytoin Pathway, Pharmacokinetics0.00
    Tamoxifen metabolism0.00
    Tamoxifen Pathway, Pharmacokinetics0.00
    Benzodiazepine Pathway, Pharmacokinetics0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Cyclophosphamide Pathway, Pharmacokinetics0.00
    cytochrome P4500.74
    Ifosfamide Pathway, Pharmacokinetics0.00
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Artemisinin and Derivatives Pathway, Pharmacokinetics0.00
    Drug metabolism - cytochrome P4500.69
    4Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Taxane Pathway, Pharmacokinetics0.30
    5Metabolism
    Metabolism0.38
    Metabolic pathways0.38


    Find genes that share SuperPaths with CYP3A5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for CYP3A5
        Estradiol metabolism
    Retinol metabolism
    Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    4 BioSystems Pathways for CYP3A5
        cytochrome P450
    Irinotecan Pathway
    Tamoxifen metabolism
    metapathway biotransformation


    1 Reactome Pathway for CYP3A5
        Xenobiotics

    Selected PharmGKB Pathways for CYP3A5 (see all 22)
        Artemisinin and Derivatives Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics
    Clopidogrel Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP3A5) (see all 6):
        Steroid hormone biosynthesis
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP3A5: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP3A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP3A5 (ENSP000002229824) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALOX15ENSP000002937614STRING: ENSP00000293761
    CES2ENSP000003178424STRING: ENSP00000317842
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process TAS2732228
    GO:0009822alkaloid catabolic process IDA15039299
    GO:0042737drug catabolic process IDA15039299
    GO:0044281small molecule metabolic process TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP3A5 (CP3A5)

    Selected HMDB Compounds for CYP3A5 (see all 52)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Selected DrugBank Compounds for CYP3A5 (see all 167)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AlfentanilAlfentanilum [INN-Latin] (see all 2)71195-58-9enzymesubstrate17554244 19934256 15557344 15731592
    MidazolamDea No. 2884 (see all 4)59467-70-8enzymesubstrate12814972 7826796 19934256 11996015
    Atorvastatin-- 134523-00-5enzymesubstrate11038166 19934256 19515014
    Ifosfamide-- 3778-73-2enzymesubstrate16702183 19515014 10348794
    SaxagliptinBMS-477118 (see all 2)361442-04-8enzymesubstrate21332626 21651615 20690781
    Alprazolam-- 28981-97-7enzymesubstrate19934256 19515014
    Axitinib-- 319460-85-0enzymesubstrate23677771 22170007
    Clopidogrel-- 113665-84-2enzymesubstrate19934256 19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438 19733976
    Diazepam-- 439-14-5enzymesubstrate19934256 19515014

    Selected Novoseek inferred chemical compound relationships for CYP3A5 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-phenylpropionamide 80.8 5 15731592 (2), 15557344 (1)
    noralfentanil 79.8 5 15731592 (2), 15557344 (1)
    tacrolimus 77.1 163 16424824 (7), 15951320 (7), 16249748 (6), 18334918 (5) (see all 47)
    ibrolipim 74.5 1 15681896 (1)
    midazolam 70.6 32 12433824 (3), 16243813 (3), 17554244 (3), 16638818 (2) (see all 14)
    4-hydroxymidazolam 66.8 2 8185679 (2)
    1-hydroxymidazolam 65.3 4 12433824 (2), 8185679 (2)
    paliperidone 63.3 2 18708991 (2)
    carebastine 62.1 1 16896065 (1)
    ketoconazole 61.3 3 9929500 (1), 15731592 (1), 15557344 (1)

    Selected PharmGKB related drug/compound annotations for CYP3A5 gene (see all 25)    About this table
    Drug/compound PharmGKB Annotation
    amlodipineCA  
    atorvastatinCA  
    boceprevir
    brentuximab vedotin
    crizotinib
    cyclosporineCA  
    efavirenzCA  
    ivacaftor
    lovastatinCA  
    maraviroc



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP3A5 gene (2 alternative transcripts): 
    NM_000777.3  NM_001190484.1  

    Unigene Cluster for CYP3A5:

    Cytochrome P450, family 3, subfamily A, polypeptide 5
    Hs.571258  [show with all ESTs]
    Unigene Representative Sequence: BX537676
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222982(uc003urq.3 uc003urs.3 uc010lgg.3) ENST00000469887
    ENST00000461920 ENST00000488187 ENST00000473347 ENST00000463364 ENST00000481825
    ENST00000466061 ENST00000480723 ENST00000463907 ENST00000439761(uc003urt.3)
    ENST00000469622 ENST00000456417 ENST00000489231 ENST00000343703 ENST00000339843(uc003urr.3 uc011kiy.2)

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    Additional mRNA sequence: 

    AF355801.1 AF355804.1 AJ563378.1 AJ563379.1 AK223008.1 AK296205.1 AK299002.1 AK309166.1 
    AK313813.1 BC022298.1 BC025176.1 BC026255.1 BC033862.1 BX537676.1 BX648856.1 J04813.1 
    L26985.1 NR_033807.1 NR_033808.1 NR_033809.1 NR_033810.1 NR_033811.1 NR_033812.1 X90579.1 

    23 DOTS entries:

    DT.313245  DT.91751640  DT.121068158  DT.313246  DT.75139376  DT.100840559  DT.101982961  DT.100792127 
    DT.95261830  DT.99974859  DT.95259273  DT.100792126  DT.102845494  DT.121068268  DT.91828403  DT.95096728 
    DT.99943618  DT.100643862  DT.100775926  DT.121068247  DT.40191552  DT.86855768  DT.95197631 

    Selected AceView cDNA sequences (see all 152):

    CK823630 CB164323 AL579869 AV646480 CA775883 AF355802 AK097322 BM850407 
    AK055879 AV720071 BC025176 CR606644 AA076069 BM856519 BX483833 AV651366 
    NM_000777 BX648856 J04813 AF355804 AI970079 CR620792 BX097094 AV646431 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP3A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP3A5 Expression
    About this image

    CYP3A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP3A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.571258
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP3A5: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYP3A5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp3a41a5
    Cyp3a111
    cytochrome P450, family 3, subfamily a, polypeptide more1, 5 78.24(n)1
    73.25(a)1
      5 (85.17 cM)5
    131121  NM_007818.31  NP_031844.11 
     1456940605 
    chicken
    (Gallus gallus)
    Aves CYP3A376
    Gallus gallus cytochrome P450 A 37 (CYP3A7), mRNA....
    58(a)
    1 → many
    14(3919206-3928547) ENSGALG00000004449
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    58(a)
    52(a)
    many ↔ many
    many ↔ many
    GL343591.1(16157-77793)
    GL343987.1(113184-127496)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.194502 Transcribed sequence with weak similarity to protein more 76.12(n)    BX779027.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.252082 Transcribed sequence with weak similarity to protein more 73.69(n)    CF999879.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp6a173
    Cyp9c11
    cytochrome P4503
    Cytochrome P450-9c11
    34(a)
    (best of 36)3
    46.49(n)1
    35.41(a)1
      51D13
    379411  NM_079126.31  NP_523850.11 


    ENSEMBL Gene Tree for CYP3A5 (if available)
    TreeFam Gene Tree for CYP3A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP3A5 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  
    CYP3A72  CYP4V22  CYP4B12  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    Selected SIMAP similar genes for CYP3A5 using alignment to 9 protein entries:     CP3A5_HUMAN (see all proteins) (see all similar genes):
    DKFZp686I18188    CYP3A43/CYP3A4    CYP3A4    CYP3A7    CYP3A43    KLKB1
    CYP4V2    TBXAS1    CYP27C1    CYP4B1    CYP11B1    CYP46A1
    CYP4F12    CYP2E1    thromboxane synthase    CYP4F11    CYP4A11    CYP4A22

    Find genes that share paralogs with CYP3A5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP3A5 (see all 690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380636291,2
    C--98633053(+) CTTTT-/CTCTC 
            
    CTCTC
    8 -- int10--------
    rs1834324041,2
    C--98633062(+) TCCTCC/TCCTCT 8 -- int10--------
    rs1456067321,2
    C--98633065(+) TCTCCA/TCTCCT 8 -- int10--------
    rs1137360341,2
    C--98633073(+) TCCTCC/TCCCCT 8 -- int10--------
    rs25285161,2
    C--98633084(-) GGGAGA/G/TGGAGG 8 -- int1 trp30--------
    rs109532901,2
    C,H--98633089(+) cctccC/Tctccc 8 -- int1 trp31Minor allele frequency- T:0.50WA 2
    rs1411565441,2
    C--98633091(+) CCCCT-/CCCCCT 8 -- int10--------
    rs1419369091,2
    C--99251073(+) GTCTC-/AAAT/ 
    AAATAAAT
    AAATA
    4 -- int10--------
    rs30639341,2
    C--99251109(+) TAAAT-/AAAT/ 
    AAATAAAT
    TTGTG
    4 -- int11NA 2
    rs25285171,2
    C--99273271(-) GGGAGA/G/TGGGGA 8 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for CYP3A5 (99245813 - 99277621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP3A5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5865CNV Insertion18451855
    esv2619613CNV Insertion19546169

    The Human Cytochrome P450 Allele Nomenclature Database: CYP3A5 
    Human Gene Mutation Database (HGMD): CYP3A5
    Locus Specific Mutation Databases (LSDB): CYP3A5

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A5
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP3A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605325   
    OMIM disorders: 145500  
    4 diseases for CYP3A5:    
    About MalaCards
    engraftment syndrome    hypertension, essential, salt-sensitive    warfarin sensitivity    multiple chemical sensitivity

    1 disease from the University of Copenhagen DISEASES database for CYP3A5:
    Oral submucous fibrosis

    Find genes that share disorders with CYP3A5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP3A5 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 13.5 9 15876487 (2), 17914095 (2), 18566991 (1), 17116727 (1) (see all 5)
    breast cancer 10.3 10 15596297 (2), 19332043 (2), 15632378 (1), 17244352 (1) (see all 8)
    cancer lung 5.38 1 14515059 (1)
    lymphoblastic leukemia acute 4.34 1 12969965 (1)
    neutropenia 3.18 1 19696793 (1)
    adenocarcinoma lung 1.58 2 15698577 (1), 12538830 (1)
    tumors 0.497 9 15596297 (3), 18566991 (1), 8869826 (1), 16281975 (1) (see all 6)
    leukemia 0 2 15312409 (1), 19650988 (1)
    inflammation 0 1 18566991 (1)
    adenoma 0 7 16281975 (5), 17363580 (1)

    Genetic Association Database (GAD): CYP3A5
    Human Genome Epidemiology (HuGE) Navigator: CYP3A5 (428 documents)

    Export disorders for CYP3A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP3A5 gene, integrated from 10 sources (see all 721):
    (articles sorted by number of sources associating them with CYP3A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PubMed id 17554244)1, 4, 7, 9 Kharasch E.D....Ensign D. (Clin. Pharmacol. Ther. 2007)
    2. Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. (PubMed id 18496131)1, 4, 7, 9 Ekhart C....Huitema A.D. (Pharmacogenet. Genomics 2008)
    3. Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PubMed id 11502729)1, 2, 4, 9 Chou F.C.... Huang J.D. (Drug Metab. Dispos. 2001)
    4. Lipid-lowering response to statins is affected by CYP3A5 polymorphism. (PubMed id 15284534)1, 4, 7 KivistAP K.T....Strandberg T. (Pharmacogenetics 2004)
    5. Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. (PubMed id 12893984)1, 2, 4 Lee S.J.... Goldstein J.A. (Pharmacogenetics 2003)
    6. Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5. (PubMed id 16338276)1, 4, 9 Mouly S.J....Watkins P.B. (Clin. Pharmacol. Ther. 2005)
    7. Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. (PubMed id 15454734)1, 4, 9 Wojnowski L....Wild C.P. (Pharmacogenetics 2004)
    8. [Polymorphisms of CYP3A5 gene in acute leukemia patients and their role in chemotherapy and prognosis]. (PubMed id 18315894)1, 4, 9 Shen L.J....Ouyang R.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    9. Tacrolimus dose requirement in relation to donor and recipient ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients. (PubMed id 16628701)1, 4, 9 Wei-lin W....Sheng Y. (Liver Transpl. 2006)
    10. CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population. (PubMed id 16906018)1, 4, 9 Mirghani R.A....Bertilsson L. (Pharmacogenet. Genomics 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1577 HGNC: 2638 AceView: CYP3A5 Ensembl:ENSG00000106258 euGenes: HUgn1577
    ECgene: CYP3A5 Kegg: 1577 H-InvDB: CYP3A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP3A5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP3A5 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp3a5.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP3A5 gene:
    Search GeneIP for patents involving CYP3A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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