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Aliases for CYP3A5 Gene

Aliases for CYP3A5 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 5 2 3 5
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 2 3
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 2 3
  • Cytochrome P450 HLp2 3 4
  • Cytochrome P450-PCN3 3 4
  • EC 1.14.14.1 4 58
  • CYPIIIA5 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 3A5 3
  • P450PCN3 3
  • CP35 3
  • PCN3 3

External Ids for CYP3A5 Gene

Previous GeneCards Identifiers for CYP3A5 Gene

  • GC07M097780
  • GC07M098843
  • GC07M098857
  • GC07M098891
  • GC07M099083
  • GC07M099246
  • GC07M093882

Summaries for CYP3A5 Gene

Entrez Gene Summary for CYP3A5 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP3A5 Gene

CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Cyp3a5-Related Altered Drug Metabolism. Among its related pathways are Imipramine/Desipramine Pathway, Pharmacokinetics and Metabolism. GO annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP3A4.

UniProtKB/Swiss-Prot for CYP3A5 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP3A5 Gene

PharmGKB "VIP" Summary for CYP3A5 Gene

Additional gene information for CYP3A5 Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A5 Gene

Genomics for CYP3A5 Gene

Regulatory Elements for CYP3A5 Gene

Enhancers for CYP3A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H099692 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.3 -14.2 -14223 2 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 PDAP1 PTCD1 C7orf43 CYP3A5 SAP25 ZSCAN25 TMEM225B CYP3A43 CYP3A4 AZGP1
GH07H099676 1.3 Ensembl ENCODE 10.2 +1.4 1357 3 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF766 FOS SP3 SP5 CYP3A5 STAG3L5P ZSCAN25 ZKSCAN5 LAMTOR4 GC07M099673 GC07M099672
GH07H099497 1.4 ENCODE dbSUPER 9.3 +180.6 180635 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZSCAN25 PPP1R35 PTCD1 TRIM4 MEPCE TRRAP ZNF655 AP4M1 LOC101927550 STAG3L5P
GH07H099616 1.4 ENCODE dbSUPER 7.3 +61.8 61758 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZSCAN25 TRRAP ZNF3 AP4M1 TRIM4 ENSG00000242798 LOC100131859 LOC100419643 PPP1R35 PTCD1
GH07H099728 1.2 ENCODE dbSUPER 7.7 -49.6 -49628 3 PKNOX1 FOXA2 ARID4B FEZF1 ZBTB40 RAD21 ATF7 HMG20B USF2 CEBPB GIGYF1 CYP3A5 ZSCAN25 ZKSCAN5 PIR41599 CYP3A7 CYP3A7-CYP3A51P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP3A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP3A5 Gene

Chromosome:
7
Start:
99,648,189 bp from pter
End:
99,680,026 bp from pter
Size:
31,838 bases
Orientation:
Minus strand

Genomic View for CYP3A5 Gene

Genes around CYP3A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A5 Gene

Proteins for CYP3A5 Gene

  • Protein details for CYP3A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20815-CP3A5_HUMAN
    Recommended name:
    Cytochrome P450 3A5
    Protein Accession:
    P20815
    Secondary Accessions:
    • A4D289
    • B7Z5I7
    • Q53WY8
    • Q75MV0
    • Q9HB56

    Protein attributes for CYP3A5 Gene

    Size:
    502 amino acids
    Molecular mass:
    57109 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Alternative splice isoforms for CYP3A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A5 Gene

Selected DME Specific Peptides for CYP3A5 Gene

P20815:
  • LFPFLTP
  • LAVETWLLLAV
  • VLVKECYSVFTN
  • LVLLYLYGT
  • PGPTPLP
  • PCKETQIPLK
  • EEWKRIR
  • SVFTNRR
  • PNKAPPTYD
  • LLSPTFT
  • LSPTFTSG
  • PTFTSGK
  • DFLQLMIDSQ
  • EAEKGKP
  • SHKALSD

Post-translational modifications for CYP3A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CYP3A5 Gene

Gene Families for CYP3A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P20815

UniProtKB/Swiss-Prot:

CP3A5_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A5: view

Function for CYP3A5 Gene

Molecular function for CYP3A5 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved in the matabolism of sex hormones
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A5 Gene

Phenotypes From GWAS Catalog for CYP3A5 Gene

Gene Ontology (GO) - Molecular Function for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS,ISS --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IDA 15039299
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA --
genes like me logo Genes that share ontologies with CYP3A5: view
genes like me logo Genes that share phenotypes with CYP3A5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CYP3A5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP3A5 Gene

Localization for CYP3A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A5 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP3A5: view

Pathways & Interactions for CYP3A5 Gene

genes like me logo Genes that share pathways with CYP3A5: view

Gene Ontology (GO) - Biological Process for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 14559847
GO:0009822 alkaloid catabolic process IDA 15039299
GO:0042737 drug catabolic process IDA 15039299
genes like me logo Genes that share ontologies with CYP3A5: view

No data available for SIGNOR curated interactions for CYP3A5 Gene

Drugs & Compounds for CYP3A5 Gene

(365) Drugs for CYP3A5 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Midazolam Approved, Illicit Pharma Enzyme, substrate 758
Tacrolimus Approved, Investigational Pharma Enzyme, substrate 1125
Cilostazol Approved Pharma Enzyme, substrate PDE3 inhibitor 110
Docetaxel Approved May 1996, Investigational Pharma Enzyme, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1993
Carbamazepine Approved, Investigational Pharma Enzyme, inducer 132

(49) Additional Compounds for CYP3A5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2

(3) ApexBio Compounds for CYP3A5 Gene

Compound Action Cas Number
Clarithromycin 81103-11-9
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
Dafadine-A DAF-9 cytochrome P450 inhibitor 1065506-69-5
genes like me logo Genes that share compounds with CYP3A5: view

Drug Products

Transcripts for CYP3A5 Gene

Unigene Clusters for CYP3A5 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CYP3A5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A5 Gene

No ASD Table

Relevant External Links for CYP3A5 Gene

GeneLoc Exon Structure for
CYP3A5
ECgene alternative splicing isoforms for
CYP3A5

Expression for CYP3A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP3A5 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A5 Gene

This gene is overexpressed in Liver (x19.3) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for CYP3A5 Gene

This gene is overexpressed in Gallbladder (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A5 Gene



Protein tissue co-expression partners for CYP3A5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP3A5 Gene:

CYP3A5

SOURCE GeneReport for Unigene cluster for CYP3A5 Gene:

Hs.571258

Evidence on tissue expression from TISSUES for CYP3A5 Gene

  • Liver(4.9)
  • Intestine(4.6)
  • Kidney(3.1)
  • Blood(2.4)
  • Lung(2.1)
  • Skin(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with CYP3A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A5 Gene

Orthologs for CYP3A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A5 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia CYP3A12 34
  • 79 (a)
ManyToMany
CYP3A26 34
  • 77 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 33 34
  • 78.24 (n)
Cyp3a13 34
  • 74 (a)
ManyToMany
Cyp3a41a 34
  • 72 (a)
ManyToMany
Cyp3a41b 34
  • 72 (a)
ManyToMany
Cyp3a25 34
  • 71 (a)
ManyToMany
Cyp3a44 16 34
  • 70 (a)
Cyp3a16 34
  • 70 (a)
ManyToMany
Cyp3a59 34
  • 69 (a)
ManyToMany
Cyp3a57 34
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp3a23/3a1 33
  • 77.62 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 74 (a)
ManyToMany
CYP3A5 34 34
  • 73 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A37 34
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 58 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19450 33
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 34
  • 51 (a)
ManyToMany
cyp3c1l2 34
  • 49 (a)
ManyToMany
cyp3c4 34
  • 49 (a)
ManyToMany
cyp3c1 34
  • 48 (a)
ManyToMany
si:dkey-21n8.3 34
  • 48 (a)
ManyToMany
Dr.25208 33
fruit fly
(Drosophila melanogaster)
Insecta Cyp9c1 35 33
  • 46.49 (n)
Cyp6a17 35
  • 34 (a)
Cyp6a23 35
  • 34 (a)
Cyp6v1 35
  • 33 (a)
Cyp6a13 35
  • 32 (a)
Cyp6a14 35
  • 32 (a)
Cyp6a19 35
  • 32 (a)
Cyp6a2 35
  • 32 (a)
Cyp6a9 35
  • 32 (a)
Cyp6g1 35
  • 32 (a)
Cyp9f2 35
  • 32 (a)
Cyp6a18 35
  • 31 (a)
Cyp6a20 35
  • 31 (a)
Cyp6a22 35
  • 31 (a)
Cyp6d4 35
  • 31 (a)
Cyp9b2 35
  • 31 (a)
Cyp6a21 35
  • 30 (a)
Cyp6a8 35
  • 30 (a)
Cyp6d5 35
  • 30 (a)
Cyp9h1 35
  • 30 (a)
Cyp6g2 35
  • 29 (a)
Cyp6w1 35
  • 29 (a)
Cyp9b1 35
  • 29 (a)
Cyp28d1 35
  • 28 (a)
Cyp28d2 35
  • 28 (a)
Cyp6d2 35
  • 28 (a)
Cyp6t3 35
  • 28 (a)
Cyp313a1 35
  • 27 (a)
Cyp317a1 35
  • 27 (a)
Cyp28c1 35
  • 26 (a)
Cyp309a2 35
  • 26 (a)
Cyp313a2 35
  • 26 (a)
Cyp6u1 35
  • 26 (a)
Cyp28a5 35
  • 25 (a)
Cyp309a1 35
  • 25 (a)
Cyp6t1 35
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F14F7.2 35
  • 32 (a)
T10B9.1 35
  • 32 (a)
F14F7.3 35
  • 31 (a)
T10B9.2 35
  • 31 (a)
T10B9.8 35
  • 30 (a)
C36A4.1 35
  • 29 (a)
C36A4.2 35
  • 29 (a)
T10B9.5 35
  • 29 (a)
T10B9.7 35
  • 29 (a)
C36A4.6 35
  • 28 (a)
F42A6.4 35
  • 28 (a)
T10B9.3 35
  • 28 (a)
ZK1320.4 35
  • 27 (a)
K06G5.2 35
  • 26 (a)
ccp-44 35
  • 25 (a)
Species where no ortholog for CYP3A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A5 Gene

ENSEMBL:
Gene Tree for CYP3A5 (if available)
TreeFam:
Gene Tree for CYP3A5 (if available)

Paralogs for CYP3A5 Gene

Variants for CYP3A5 Gene

Sequence variations from dbSNP and Humsavar for CYP3A5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs776746 drug-response 99,672,916(-) TTTCA(A/G)TATCT intron-variant, upstream-variant-2KB, splice-acceptor-variant, utr-variant-5-prime
rs4646450 other 99,668,695(-) tggca(C/T)tgcaa intron-variant, upstream-variant-2KB
rs1000111953 -- 99,680,238(+) CCCTC(C/T)ATGGC intron-variant, upstream-variant-2KB
rs1000188828 -- 99,654,881(+) GTCTT(C/T)TGAGA intron-variant
rs1000203154 -- 99,654,534(+) CTGCA(A/G)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A5 Gene

Variant ID Type Subtype PubMed ID
esv2619613 CNV insertion 19546169
nsv5865 CNV insertion 18451855
nsv970911 CNV duplication 23825009

Variation tolerance for CYP3A5 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP3A5 Gene

Human Gene Mutation Database (HGMD)
CYP3A5
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A5 Gene

Disorders for CYP3A5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CYP3A5 Gene - From: HGMD, OMIM, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypertension, essential
  • hypertension, essential 3
cyp3a5-related altered drug metabolism
tacrolimus dose selection
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
engraftment syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP3A5

Genetic Association Database (GAD)
CYP3A5
Human Genome Epidemiology (HuGE) Navigator
CYP3A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A5
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No data available for UniProtKB/Swiss-Prot and Genatlas for CYP3A5 Gene

Publications for CYP3A5 Gene

  1. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PMID: 17554244) Kharasch ED … Ensign D (Clinical pharmacology and therapeutics 2007) 3 22 25 45 60
  2. Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PMID: 11502729) Chou FC … Huang JD (Drug metabolism and disposition: the biological fate of chemicals 2001) 3 4 22 45 60
  3. CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men. (PMID: 19812606) Zhang L … Muramatsu M (Journal of human hypertension 2010) 3 22 45 60
  4. Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. (PMID: 20357698) Mukonzo JK … Aklillu E (Therapeutic drug monitoring 2010) 3 22 45 60
  5. Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. (PMID: 19696793) Low SK … Zembutsu H (Journal of human genetics 2009) 3 22 45 60

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Sources for CYP3A5 Gene

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