Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP3A43 Gene

protein-coding GIFtS: 62
GCID: GC07P099426

cytochrome P450, family 3, subfamily A, polypeptide 43

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 43 )

Explore 23 diseases affiliated with
CYP3A43 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 43¹ ²
Cytochrome P450, Subfamily IIIA, Polypeptide 43¹ ²
EC 1.14.14.1³ ⁸
Cytochrome P450 3A43²
Cytochrome P450 Polypeptide 43²

External Ids:	HGNC: 17450¹	Entrez Gene: 64816²	Ensembl: ENSG00000021461⁷	OMIM: 606534⁵	UniProtKB: Q9HB55³

Export aliases for CYP3A43 gene to outside databases

Previous GC identifers: GC07P097960 GC07P099023 GC07P099037 GC07P099070 GC07P099263 GC07P094062

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP3A43:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some

drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This

gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in

three transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55

Function: Exhibits low testosterone 6-beta-hydroxylase activity

Gene Wiki entry for CYP3A43

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP3A43 gene promoter:
CHOP-10 PPAR-gamma1 PPAR-gamma2 Ik-3 GATA-1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP3A43 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP3A43

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A43

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.1

CYP3A43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A43 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P099426: view genomic region (about GC identifiers)

Start:	99,425,636 bp from pter	End:	99,464,173 bp from pter
Size:	38,538 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 98,785,456-98,823,992

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55 (See protein sequence)

Recommended Name: Cytochrome P450 3A43

Size: 503 amino acids; 57670 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Miscellaneous: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets

of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric

transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1

joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric

isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform

(CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different

combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon

12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664)

Secondary accessions: Q75MK2 Q9HB52 Q9HB53 Q9HB54 Q9HB57

Alternative splicing: 4 isoforms: Q9HB55-1 Q9HB55-2 Q9HB55-3 Q9HB55-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CYP3A43: NX_Q9HB55

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HB55

4/8 DME Specific Peptides for CYP3A43 (Q9HB55) (see all 8)

PGPTPLP

KESRLKD

LFPFLTP

EEWKRIR

CYP3A43 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_073731.1 NP_476436.1 NP_476437.1

ENSEMBL proteins:

ENSP00000346887 ENSP00000415221 ENSP00000416581 ENSP00000405557 ENSP00000401521

ENSP00000400316 ENSP00000411653 ENSP00000312110 ENSP00000222382 ENSP00000397332

ENSP00000345351

Reactome Protein details: Q9HB55
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): CYP3A43 OriGene Custom Protein Services for CYP3A43
	GenScript Custom Purified and Recombinant Proteins Services for CYP3A43
	Novus Biologicals CYP3A43 Protein Novus Biologicals CYP3A43 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYP3A43

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP3A43 for ontologies About GeneDecksing

CYP3A43 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CYP3A43
	GenScript Custom Superior Antibodies Services for CYP3A43
	Novus Biologicals CYP3A43 Antibodies
	Search for Antibodies for CYP3A43 at Abcam
	Uscn Antibodies for CYP3A43
	ThermoFisher Antibody for CYP3A43

Assay Products for CYP3A43:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CYP3A43
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYP3A43

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP3A43 for domains About GeneDecksing

4 InterPro domains/families:

IPR008072 Cyt_P450_E_CYP3A

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002402 Cyt_P450_E_grp-II

Graphical View of Domain Structure for InterPro Entry Q9HB55

ProtoNet protein and cluster: Q9HB55

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008072 CYP3A P450 family signature

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55

Function: Exhibits low testosterone 6-beta-hydroxylase activity

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: By rifampicin

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CYP3A43 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP3A43
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CYP3A43:
		hsa-miR-4314 hsa-miR-1256
		SwitchGear 3'UTR luciferase reporter plasmid: CYP3A43 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP3A43 (see all 4) OriGene shRNA RFP: CYP3A43 OriGene siRNA: CYP3A43
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP3A43

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CYP3A43

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP3A43 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP3A43 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CYP3A43 (NM_022820)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP3A43
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP3A43

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYP3A43
		Search LifeMap BioReagents cell lines for CYP3A43

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A43

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	ISS	--
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--
GO:0020037	heme binding	IEA	--

CYP3A43 for ontologies About GeneDecksing

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cyp3a57):

no phenotypic analysis

CYP3A43 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Biological oxidations

Biological oxidations

1.00

metapathway biotransformation

0.41

Miscellaneous substrates

Miscellaneous substrates

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for CYP3A43

	cytochrome P450
	metapathway biotransformation

5 Reactome Pathways for CYP3A43

	Cytochrome P450 - arranged by substrate type
	Miscellaneous substrates
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

5/7 Kegg Pathways (Kegg details for CYP3A43) (see all 7):

	Steroid hormone biosynthesis
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

CYP3A43 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP3A43

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/97 Interacting proteins for CYP3A43 (ENSP00000222382⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 97)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785
ALDH1A2	ENSP00000249750⁴	STRING: ENSP00000249750
ALOX15	ENSP00000293761⁴	STRING: ENSP00000293761
CES2	ENSP00000317842⁴	STRING: ENSP00000317842
CES5A	ENSP00000290567⁴	STRING: ENSP00000290567

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CYP3A43 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP3A43

10/50 HMDB Compounds for CYP3A43 (see all 50) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

10 DrugBank Compounds for CYP3A43 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dexamethasone	Desametasone (see all 9)	50-02-2	enzyme	inducer	19934256
Ethosuximide	Aethosuximide (see all 5)	77-67-8	enzyme	substrate	19934256
Oxazepam	Oxazipam (see all 2)	604-75-1	enzyme	substrate	19934256
Phenelzine	--	51-71-8	enzyme	inhibitor	19934256
Praziquantel	--	55268-74-1	enzyme	substrate	19934256
Rifampin	RFP (see all 3)	13292-46-1	enzyme	inducer	19934256
Rifapentine	--	61379-65-5	enzyme	inducer	19934256
Testosterone	TES (see all 9)	58-22-0	enzyme	substrate	19934256
Troleandomycin	Oleandocetine (see all 5)	2751-09-9	enzyme	inducer	11095572
Zalcitabine	DDC (see all 3)	7481-89-2	enzyme	substrate	19934256

Search CenterWatch for drugs/clinical trials and news about CYP3A43 / CP343

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP3A43 gene (3 alternative transcripts):

NM_022820.3 NM_057095.1 NM_057096.2

Unigene Cluster for CYP3A43:

Cytochrome P450, family 3, subfamily A, polypeptide 43

Hs.306220 [show with all ESTs]

Unigene Representative Sequence: NM_022820

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354829(uc003urx.1 uc003ury.1 uc003urz.1 uc003usa.1 uc010lgi.1)

ENST00000436834 ENST00000417625 ENST00000463915 ENST00000444905 ENST00000415413

ENST00000477658 ENST00000495115 ENST00000433277 ENST00000491648 ENST00000481362

ENST00000434806 ENST00000312017 ENST00000222382 ENST00000472352 ENST00000421837

ENST00000342499(uc003usb.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CYP3A43 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP3A43
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CYP3A43:
		hsa-miR-4314 hsa-miR-1256
		SwitchGear 3'UTR luciferase reporter plasmid: CYP3A43 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP3A43 (see all 4) OriGene shRNA RFP: CYP3A43 OriGene siRNA: CYP3A43
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP3A43

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP3A43 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP3A43 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CYP3A43 (NM_022820)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP3A43
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP3A43

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP3A43 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CYP3A43
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3A43
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3A43

Additional cDNA sequence:

AF280108.1 AF280109.1 AF280110.1 AF280111.1 AF280112.1 AF280113.1 AF319634.1 AF337813.1

AY390423.1 AY390424.1 AY390425.1 AY390426.1 BC100981.3 BC100982.3

3 DOTS entries:

DT.104214 DT.100745110 DT.99960925

20 AceView cDNA sequences:

AY390424 AF280112 NM_057096 AY390425 NM_022820 BX092633 AF280108 NM_057095

AF280109 AF280111 AY390423 AF319634 AY390426 AA417369 AW662829 AF337813

AA416822 BX951468 AF280110 AF280113

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A43 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b
SP1:									-								-
SP2:									-								-						-
SP3:									-								-						-
SP4:									-								-						-										-
SP5:													-		-		-		-		-		-

ECgene alternative splicing isoforms for CYP3A43

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP3A43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCATTTGT

About this image
See CYP3A43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP3A43

SOURCE GeneReport for Unigene cluster: Hs.306220

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55

Tissue specificity: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and

fetal skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including CYP3A43:

Drug Metabolism: Phase I Enzymes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP3A43 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CYP3A43
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3A43
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3A43

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A43

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CYP3A43 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NT18_CHICK⁶	cytochrome P450 A 37	56(a)	1 → many	14(3939211-3948991)
lizard (Anolis carolinensis)	Reptilia	--	--	48(a)	1 → many	GL343987.1(114011-127496)
zebrafish (Danio rerio)	Actinopterygii	BC052130.1²	--	72.92(n)		BC052130.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp6g1³ Cyp9f2¹	DDT resistance cytochrome P450³ CG11466-PA¹	33(a) (best of 34)³ 47.29(n)¹ 35.79(a)¹		2 48E7³ 41520¹ NM_141932.2¹ NP_650189.1¹

ENSEMBL Gene Tree for CYP3A43 (if available)
TreeFam Gene Tree for CYP3A43 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP3A43 gene

CYP4F22² CYP4F3² CYP4F2² CYP4F11² CYP46A1² ENSG00000225607² CYP4B1² CYP3A5²

CYP4X1² TBXAS1² CYP3A4² CYP3A7² CYP4V2² CYP4A22² CYP4A11² CYP4F12²

CYP4Z1²

18 SIMAP similar genes for CYP3A43 using alignment to 12 protein entries: CP343_HUMAN (see all proteins):

CYP3A7 C8orf17 CYP3A43/CYP3A4 CYP3A5 CYP3A4 CYP46A1

CYP4A11 TBXAS1 CYP2U1 CYP19A1 CYP2R1 CYP4B1

thromboxane synthase CYP2D6 CYP1A1 CYP2E1 CYP2C9 CYP26B1

CYP3A43 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55

Polymorphism: At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that

of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs473706^1,2	C,F,H,	--	98784571(-)	`ACCTCC/TGAGGC`	3	--	us2k¹		18		NS EA NA CSA WA	1910
rs61034029^1,2	C,	--	98784933(+)	`TTTGGC/AAACCT`	3	--	us2k¹		2		WA	120
rs76530127^1,2	F,	--	98785154(+)	`TTGAGG/ATTGGA`	3	--	us2k¹		1		WA	118
rs45585936^1,2	C,F,	--	98785318(+)	`AATTAT/GTTGCC`	3	--	us2k¹		2		--	192
rs45600736^1,2	C,F,	--	98785435(+)	`ATATCG/ACTGTT`	3	--	us2k¹		2		--	192
rs45577236^1,2	C,F,	--	98785478(+)	`CAAAGC/TTCTAT`	3	--	ut5¹		20		MN WA EA NA	3004
rs10255255^1,2	C,	--	98785958(+)	`aattaG/Ttcagg`	3	--	int¹		0	--	--	--	--
rs28560287^1,2	F,	--	98786190(+)	`CTGACC/GCTCTT`	3	--	int¹		1		WA	118
rs585071^1,2	C,F,A,H,	--	98786622(-)	`GAATCT/CCTTGG`	3	--	int¹		19		NS EA NA WA CSA	1971
rs60966462^1,2	F,	--	98786670(+)	`ACAGGG/AGAATT`	3	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for CYP3A43 (99425636 - 99464173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CYP3A43
4 CNVs: 94732 64899 82103 94733
Human Gene Mutation Database (HGMD): CYP3A43

Locus Specific Mutation Databases (LSDB): CYP3A43

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP3A43

DNA2.0 Custom Variant and Variant Library Synthesis for CYP3A43

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP3A43 for disorders           About GeneDecksing

OMIM gene information: 606534    OMIM disorders: --

20/23 diseases for CYP3A43 (see all 23):    About MalaCards

antley-bixler syndrome human immunodeficiency virus infectious disease toxic encephalopathy fascioliasis

porphyria aspergillosis constipation candidiasis

cholesterol neurodegenerative disease skin disease cholestasis

brain disease hypercholesterolemia diarrhea hepatocellular carcinoma

lung cancer prostate cancer prostatitis tuberculosis

Genetic Association Database (GAD): CYP3A43
Human Genome Epidemiology (HuGE) Navigator: CYP3A43 (12 documents)

Export disorders for CYP3A43 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP3A43 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with CYP3A43)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (PubMed id 11160876)^{1, 2, 3, 9} Domanski T.L.... Zaphiropoulos P.G. (2001)
First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. (PubMed id 14695544)^{1, 2, 4, 9} Cauffiez C.... Broly F. (2004)
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PubMed id 11266076)^{1, 2, 3, 9} Gellner K....Wojnowski L. (2001)
CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians. (PubMed id 15894682)^{1, 4} Stone A....Lang N.P. (2005)
CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. (PubMed id 15548719)^{1, 4} Zeigler-Johnson C....Rebbeck T.R. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Intergenic mRNA molecules resulting from trans-splicing. (PubMed id 11726664)^{1, 2} Finta C. and Zaphiropoulos P.G. (2002)
Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43. (PubMed id 11243885)^{1, 2} Westlind A.... Oscarson M. (2001)
Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia. (PubMed id 16848237)^{1, 9} Shchepotina E.G....Lyakhovich V.V. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64816	HGNC: 17450	AceView: CYP3A43	Ensembl:ENSG00000021461	euGenes: HUgn64816
ECgene: CYP3A43	Kegg: 64816	H-InvDB: CYP3A43

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP3A43	Pharmacogenomics, SNPs, Pathways
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp3a43.htm

Intellectual Property for CYP3A43 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CYP3A43 gene:
Search GeneIP for patents involving CYP3A43

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CYP3A43
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP3A43		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP3A43
	OriGene Protein Over-expression Lysate for CYP3A43		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CYP3A43		OriGene 3'-UTR Clone for CYP3A43
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP3A43		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP3A43
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CYP3A43		OriGene Custom Protein Services for CYP3A43
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP3A43
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP3A43
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A43
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP3A43
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3A43
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3A43

	GenScript Custom Purified and Recombinant Proteins Services for CYP3A43		GenScript cDNA clones with any tag delivered in your preferred vector for CYP3A43
	GenScript Custom Assay Services for CYP3A43		GenScript Custom Superior Antibodies Services for CYP3A43
	GenScript Custom overexpressing Cell Line Services for CYP3A43		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CYP3A43 promoter
	Search Chromatin IP Primers for CYP3A43
	RT² qPCR Primer Assay in human, mouse, rat CYP3A43
	Search GNC Networks for CYP3A43
	SABiosciences PCR Arrays including human, mouse, rat CYP3A43

Search Tocris compounds for CYP3A43

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CYP3A43 antibodies
	CYP3A43 proteins
	CYP3A43 lysates

	Search for Antibodies for CYP3A43 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CYP3A43
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CYP3A43 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CYP3A43

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A43

	SwitchGear 3'UTR luciferase reporter plasmids for CYP3A43
	SwitchGear Promoter luciferase reporter plasmids for CYP3A43

ThermoFisher Antibody for CYP3A43

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP3A43

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CYP3A43 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CYP3A43 Gene

cytochrome P450, family 3, subfamily A, polypeptide 43

Aliases
for CYP3A43 gene

Summaries
for CYP3A43 gene

Genomic Views
for CYP3A43 gene

Proteins
for CYP3A43 gene

Protein Domains /
Families
for CYP3A43 gene

Function
for CYP3A43 gene

Pathways & Interactions
for CYP3A43 gene

Drugs & Compounds
for CYP3A43 gene

Transcripts
for CYP3A43 gene

Expression
for CYP3A43 gene

Orthologs
for CYP3A43 gene

Paralogs
for CYP3A43 gene

Genomic Variants
for CYP3A43 gene

Disorders / Diseases
for CYP3A43 gene

Publications
for CYP3A43 gene

External Searches for CYP3A43 gene

Genome Databases showing CYP3A43 gene

Other Databases showing CYP3A43 gene

Specialized Databases showing CYP3A43 gene

Intellectual Property
for CYP3A43 gene

Products
for CYP3A43 gene

View Random Gene

Advanced Search

Export list of displayed genes

CYP3A43 Gene

cytochrome P450, family 3, subfamily A, polypeptide 43

Aliasesfor CYP3A43 gene

Summariesfor CYP3A43 gene

Genomic Viewsfor CYP3A43 gene

Proteinsfor CYP3A43 gene

Protein Domains /Familiesfor CYP3A43 gene

Functionfor CYP3A43 gene

Pathways & Interactionsfor CYP3A43 gene

Drugs & Compoundsfor CYP3A43 gene

Transcriptsfor CYP3A43 gene

Expression for CYP3A43 gene

Orthologsfor CYP3A43 gene

Paralogsfor CYP3A43 gene

Genomic Variantsfor CYP3A43 gene

Disorders / Diseasesfor CYP3A43 gene

Publicationsfor CYP3A43 gene

External Searches for CYP3A43 gene

Genome Databases showing CYP3A43 gene

Other Databases showing CYP3A43 gene

Specialized Databases showing CYP3A43 gene

Intellectual Propertyfor CYP3A43 gene

Productsfor CYP3A43 gene

View Random Gene

Aliases
for CYP3A43 gene

Summaries
for CYP3A43 gene

Genomic Views
for CYP3A43 gene

Proteins
for CYP3A43 gene

Protein Domains /
Families
for CYP3A43 gene

Function
for CYP3A43 gene

Pathways & Interactions
for CYP3A43 gene

Drugs & Compounds
for CYP3A43 gene

Transcripts
for CYP3A43 gene

Expression
for CYP3A43 gene

Orthologs
for CYP3A43 gene

Paralogs
for CYP3A43 gene

Genomic Variants
for CYP3A43 gene

Disorders / Diseases
for CYP3A43 gene

Publications
for CYP3A43 gene

Intellectual Property
for CYP3A43 gene

Products
for CYP3A43 gene