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Aliases for CYP3A43 Gene

Aliases for CYP3A43 Gene

  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 43 2 3
  • EC 1.14.14.1 4 63
  • Cytochrome P450, Subfamily IIIA, Polypeptide 43 2

External Ids for CYP3A43 Gene

Previous GeneCards Identifiers for CYP3A43 Gene

  • GC07P097960
  • GC07P099023
  • GC07P099037
  • GC07P099070
  • GC07P099263
  • GC07P099426
  • GC07P094062

Summaries for CYP3A43 Gene

Entrez Gene Summary for CYP3A43 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CYP3A43 Gene

CYP3A43 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 43) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP3A43 Gene

  • Exhibits low testosterone 6-beta-hydroxylase activity

Gene Wiki entry for CYP3A43 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A43 Gene

Genomics for CYP3A43 Gene

Regulatory Elements for CYP3A43 Gene

Genomic Location for CYP3A43 Gene

Start:
99,828,013 bp from pter
End:
99,866,104 bp from pter
Size:
38,092 bases
Orientation:
Plus strand

Genomic View for CYP3A43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP3A43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A43 Gene

Proteins for CYP3A43 Gene

  • Protein details for CYP3A43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB55-CP343_HUMAN
    Recommended name:
    Cytochrome P450 3A43
    Protein Accession:
    Q9HB55
    Secondary Accessions:
    • Q495Y1
    • Q75MK2
    • Q75MK3
    • Q9HB52
    • Q9HB53
    • Q9HB54
    • Q9HB57

    Protein attributes for CYP3A43 Gene

    Size:
    503 amino acids
    Molecular mass:
    57670 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Alternative splice isoforms for CYP3A43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A43 Gene

Proteomics data for CYP3A43 Gene at MOPED

Selected DME Specific Peptides for CYP3A43 Gene

Post-translational modifications for CYP3A43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for CYP3A43 Gene

Gene Families for CYP3A43 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q9HB55

UniProtKB/Swiss-Prot:

CP343_HUMAN :
  • Q9HB55
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A43: view

Function for CYP3A43 Gene

Molecular function for CYP3A43 Gene

UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Exhibits low testosterone 6-beta-hydroxylase activity
UniProtKB/Swiss-Prot Induction: By rifampicin

Enzyme Numbers (IUBMB) for CYP3A43 Gene

Gene Ontology (GO) - Molecular Function for CYP3A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP3A43: view

Phenotypes for CYP3A43 Gene

MGI mutant phenotypes for CYP3A43:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CYP3A43: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP3A43 Gene

Localization for CYP3A43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A43 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP3A43 Gene COMPARTMENTS Subcellular localization image for CYP3A43 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP3A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with CYP3A43: view

Pathways for CYP3A43 Gene

genes like me logo Genes that share pathways with CYP3A43: view

Pathways by source for CYP3A43 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CYP3A43 Gene

Gene Ontology (GO) - Biological Process for CYP3A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP3A43: view

Compounds for CYP3A43 Gene

(50) HMDB Compounds for CYP3A43 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(10) Drugbank Compounds for CYP3A43 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dexamethasone
  • Desametasone
50-02-2 enzyme inducer
Ethosuximide
  • Aethosuximide
77-67-8 enzyme substrate
Oxazepam
  • Oxazipam
604-75-1 enzyme substrate
Phenelzine
51-71-8 enzyme inhibitor
Praziquantel
55268-74-1 enzyme substrate
genes like me logo Genes that share compounds with CYP3A43: view

Transcripts for CYP3A43 Gene

Unigene Clusters for CYP3A43 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 43:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP3A43

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CYP3A43

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A43 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -

Relevant External Links for CYP3A43 Gene

GeneLoc Exon Structure for
CYP3A43
ECgene alternative splicing isoforms for
CYP3A43

Expression for CYP3A43 Gene

mRNA expression in normal human tissues for CYP3A43 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A43 Gene

This gene is overexpressed in Liver (23.8) and Pancreas (16.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP3A43 Gene

SOURCE GeneReport for Unigene cluster for CYP3A43 Gene Hs.306220

mRNA Expression by UniProt/SwissProt for CYP3A43 Gene

Q9HB55-CP343_HUMAN
Tissue specificity: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
genes like me logo Genes that share expressions with CYP3A43: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CYP3A43 Gene

Orthologs for CYP3A43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYP3A43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A43 35
  • 99.14 (n)
  • 99.01 (a)
CYP3A43 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
ManyToMany
CYP3A5 36
  • 67 (a)
ManyToMany
CYP3A5 36
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
CYP3A12 36
  • 74 (a)
ManyToMany
CYP3A26 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 36
  • 64 (a)
ManyToMany
Cyp3a13 36
  • 67 (a)
ManyToMany
Cyp3a16 36
  • 63 (a)
ManyToMany
Cyp3a25 36
  • 66 (a)
ManyToMany
Cyp3a41a 36
  • 63 (a)
ManyToMany
Cyp3a41b 36
  • 63 (a)
ManyToMany
Cyp3a44 36
  • 63 (a)
ManyToMany
Cyp3a57 16
Cyp3a57 36
  • 66 (a)
ManyToMany
Cyp3a59 36
  • 64 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A37 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 36
  • 51 (a)
ManyToMany
cyp3c1 36
  • 43 (a)
ManyToMany
cyp3c1l2 36
  • 45 (a)
ManyToMany
cyp3c4 36
  • 44 (a)
ManyToMany
si:dkey-21n8.3 36
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp6a17 37
  • 32 (a)
Cyp6d2 37
  • 26 (a)
Cyp9b1 37
  • 28 (a)
Cyp313a2 37
  • 27 (a)
Cyp6a2 37
  • 29 (a)
Cyp6g1 37
  • 33 (a)
Cyp6a21 37
  • 28 (a)
Cyp28d2 37
  • 28 (a)
Cyp6a9 37
  • 31 (a)
Cyp6t3 37
  • 27 (a)
Cyp6w1 37
  • 28 (a)
Cyp28a5 37
  • 25 (a)
Cyp6a19 37
  • 30 (a)
Cyp6d5 37
  • 28 (a)
Cyp9f2 37
  • 33 (a)
Cyp9c1 37
  • 29 (a)
Cyp309a2 37
  • 26 (a)
Cyp6t1 37
  • 25 (a)
Cyp9h1 37
  • 29 (a)
Cyp6a23 37
  • 32 (a)
Cyp6a8 37
  • 27 (a)
Cyp6a13 37
  • 30 (a)
Cyp6v1 37
  • 30 (a)
Cyp9b2 37
  • 29 (a)
Cyp28d1 37
  • 26 (a)
Cyp6a14 37
  • 31 (a)
Cyp309a1 37
  • 24 (a)
Cyp6g2 37
  • 28 (a)
Cyp6a18 37
  • 30 (a)
Cyp6d4 37
  • 30 (a)
Cyp6a20 37
  • 31 (a)
Cyp6u1 37
  • 26 (a)
Cyp28c1 37
  • 24 (a)
Cyp6a22 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea T10B9.8 37
  • 28 (a)
K06G5.2 37
  • 25 (a)
T10B9.1 37
  • 30 (a)
T10B9.5 37
  • 28 (a)
F14F7.2 37
  • 30 (a)
F42A6.4 37
  • 28 (a)
C36A4.1 37
  • 29 (a)
ZK1320.4 37
  • 26 (a)
T10B9.2 37
  • 29 (a)
F14F7.3 37
  • 29 (a)
T10B9.7 37
  • 30 (a)
T10B9.3 37
  • 28 (a)
C36A4.6 37
  • 28 (a)
C36A4.2 37
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG5 38
Species with no ortholog for CYP3A43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP3A43 Gene

ENSEMBL:
Gene Tree for CYP3A43 (if available)
TreeFam:
Gene Tree for CYP3A43 (if available)

Paralogs for CYP3A43 Gene

genes like me logo Genes that share paralogs with CYP3A43: view

Variants for CYP3A43 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A43 Gene

Q9HB55-CP343_HUMAN
At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional

Sequence variations from dbSNP and Humsavar for CYP3A43 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs472660 -- 99,862,484(-) GAGTA(C/T)AAGGG intron-variant
rs472667 -- 99,845,096(-) gcatt(A/G)aacca intron-variant
rs473706 -- 99,827,128(-) ACCTC(C/T)GAGGC upstream-variant-2KB
rs475262 -- 99,835,389(-) gtttg(A/G)cacga intron-variant
rs480596 -- 99,858,788(-) ttgaa(C/T)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A43 Gene

Variant ID Type Subtype PubMed ID
esv2670223 CNV Deletion 23128226
esv29538 CNV Loss 19812545

Relevant External Links for CYP3A43 Gene

HapMap Linkage Disequilibrium report
CYP3A43
Human Gene Mutation Database (HGMD)
CYP3A43
Locus Specific Mutation Databases (LSDB)
CYP3A43
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A43

Disorders for CYP3A43 Gene

Relevant External Links for CYP3A43

Genetic Association Database (GAD)
CYP3A43
Human Genome Epidemiology (HuGE) Navigator
CYP3A43
genes like me logo Genes that share disorders with CYP3A43: view

No data available for UniProtKB/Swiss-Prot for CYP3A43 Gene

Publications for CYP3A43 Gene

  1. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (PMID: 11160876) Domanski T.L. … Zaphiropoulos P.G. (Mol. Pharmacol. 2001) 2 3 4 23
  2. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PMID: 11266076) Gellner K. … Wojnowski L. (Pharmacogenetics 2001) 2 3 4 23
  3. First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. (PMID: 14695544) Cauffiez C. … Broly F. (Hum. Mutat. 2004) 3 4 23 48
  4. Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia. (PMID: 16848237) Shchepotina E.G. … Lyakhovich V.V. (Bull. Exp. Biol. Med. 2005) 3 23 48
  5. Joint effects of inflammation and androgen metabolism on prostate cancer severity. (PMID: 18566991) Rebbeck T.R. … Zeigler-Johnson C. (Int. J. Cancer 2008) 3 48

Products for CYP3A43 Gene

Sources for CYP3A43 Gene

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