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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP3A43 Gene

protein-coding   GIFtS: 63
GCID: GC07P099426

Cytochrome P450, Family 3, Subfamily A, Polypeptide 43

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 43)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 431 2
Cytochrome P450, Subfamily IIIA, Polypeptide 431 2
EC 1.14.14.13 8
Cytochrome P450 3A432

External Ids:    HGNC: 174501   Entrez Gene: 648162   Ensembl: ENSG000000214617   OMIM: 6065345   UniProtKB: Q9HB553   

Export aliases for CYP3A43 gene to outside databases

Previous GC identifers: GC07P097960 GC07P099023 GC07P099037 GC07P099070 GC07P099263 GC07P094062


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP3A43 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role
in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome
7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2013)

GeneCards Summary for CYP3A43 Gene: 
CYP3A43 (cytochrome P450, family 3, subfamily A, polypeptide 43) is a protein-coding gene. Diseases associated with CYP3A43 include fascioliasis, and human immunodeficiency virus infectious disease, and among its related super-pathways are Cytochrome P450 - arranged by substrate type and Phase II conjugation. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
Function: Exhibits low testosterone 6-beta-hydroxylase activity

Gene Wiki entry for CYP3A43 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP3A43 gene promoter:
         CHOP-10   PPAR-gamma1   PPAR-gamma2   Ik-3   GATA-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP3A43 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP3A43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.1

CYP3A43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A43 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099426:  view genomic region     (about GC identifiers)

Start:
99,425,636 bp from pter      End:
99,464,173 bp from pter
Size:
38,538 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,785,456-98,823,992     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55 (See protein sequence)
Recommended Name: Cytochrome P450 3A43  
Size: 503 amino acids; 57670 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Miscellaneous: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct
sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4
chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13,
CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The
longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while
a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts
exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined
in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver
(PubMed:11726664)
Secondary accessions: Q75MK2 Q9HB52 Q9HB53 Q9HB54 Q9HB57
Alternative splicing: 4 isoforms:  Q9HB55-1   Q9HB55-2   Q9HB55-3   Q9HB55-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CYP3A43: NX_Q9HB55

Explore proteomics data for CYP3A43 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HB55

  • 4/8 DME Specific Peptides for CYP3A43 (Q9HB55) (see all 8)
     PGPTPLP  KESRLKD  LFPFLTP  EEWKRIR 

    CYP3A43 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP3A43 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001265850.1  NP_073731.1  NP_476436.1  NP_476437.1  

    ENSEMBL proteins: 
     ENSP00000346887   ENSP00000415221   ENSP00000416581   ENSP00000405557   ENSP00000401521  
     ENSP00000400316   ENSP00000411653   ENSP00000312110   ENSP00000222382   ENSP00000397332  
     ENSP00000345351  
    Reactome Protein details: Q9HB55
    Human Recombinant Protein Products for CYP3A43: 
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    Cloud-Clone Corp. Proteins for CYP3A43 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    CYP3A43 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A43 
    CYP3 family

    4 InterPro protein domains:
     IPR008072 Cyt_P450_E_CYP3A
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002402 Cyt_P450_E_grp-II

    Graphical View of Domain Structure for InterPro Entry Q9HB55

    ProtoNet protein and cluster: Q9HB55

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008072 CYP3A P450 family signature


    UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
    Similarity: Belongs to the cytochrome P450 family


    CYP3A43 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP343_HUMAN, Q9HB55
    Function: Exhibits low testosterone 6-beta-hydroxylase activity
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By rifampicin

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ISS--
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
         
    CYP3A43 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cyp3a57):
     no phenotypic analysis 

    CYP3A43 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP3A43 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    Retinol metabolism0.39
    5Glucuronidation
    Drug metabolism - other enzymes0.33
    Steroid hormone biosynthesis0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP3A43
        cytochrome P450
    metapathway biotransformation

    5/6        Reactome Pathways for CYP3A43 (see all 6)
        Cytochrome P450 - arranged by substrate type
    Miscellaneous substrates
    Xenobiotics
    Metabolism
    Biological oxidations


    5/8         Kegg Pathways  (Kegg details for CYP3A43) (see all 8):
        Steroid hormone biosynthesis
    Linoleic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450


    CYP3A43 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP3A43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for CYP3A43 (ENSP000002223824) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALOX15ENSP000002937614STRING: ENSP00000293761
    CES2ENSP000003178424STRING: ENSP00000317842
    CES5AENSP000002905674STRING: ENSP00000290567
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    CYP3A43 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP3A43 (CP343)

    10/50 HMDB Compounds for CYP3A43 (see all 50)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    10 DrugBank Compounds for CYP3A43    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DexamethasoneDesametasone (see all 9)50-02-2enzymeinducer19934256
    EthosuximideAethosuximide (see all 5)77-67-8enzymesubstrate19934256
    OxazepamOxazipam (see all 3)604-75-1enzymesubstrate19934256
    Phenelzine-- 51-71-8enzymeinhibitor19934256
    Praziquantel-- 55268-74-1enzymesubstrate19934256
    RifampinRFP (see all 3)13292-46-1enzymeinducer19934256
    Rifapentine-- 61379-65-5enzymeinducer19934256
    TestosteroneTES (see all 9)58-22-0enzymesubstrate19934256
    TroleandomycinOleandocetine (see all 5)2751-09-9enzymeinducer11095572
    ZalcitabineDDC (see all 3)7481-89-2enzymesubstrate19934256

    Search CenterWatch for drugs/clinical trials and news about CYP3A43 / CP343

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section

    REFSEQ mRNAs for CYP3A43 gene (4 alternative transcripts): 
    NM_001278921.1  NM_022820.4  NM_057095.2  NM_057096.3  

    Unigene Cluster for CYP3A43:

    Cytochrome P450, family 3, subfamily A, polypeptide 43
    Hs.306220  [show with all ESTs]
    Unigene Representative Sequence: NM_022820
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354829(uc003urx.1 uc003ury.1 uc003urz.1 uc003usa.1 uc010lgi.1)
    ENST00000436834 ENST00000417625 ENST00000463915 ENST00000444905 ENST00000415413
    ENST00000477658 ENST00000495115 ENST00000433277 ENST00000491648 ENST00000481362
    ENST00000434806 ENST00000312017 ENST00000222382 ENST00000472352 ENST00000421837
    ENST00000342499(uc003usb.1)

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    Additional mRNA sequence: 

    AF280108.1 AF280109.1 AF280110.1 AF280111.1 AF280112.1 AF280113.1 AF319634.1 AF337813.1 
    AY390423.1 AY390424.1 AY390425.1 AY390426.1 BC100981.3 BC100982.3 

    3 DOTS entries:

    DT.104214  DT.100745110  DT.99960925 

    20 AceView cDNA sequences:

    AF280108 AF280112 AY390423 NM_057095 AF280111 AY390424 AF319634 AY390425 
    BX092633 NM_057096 NM_022820 AF280109 AF280113 AF337813 BX951468 AF280110 
    AA416822 AA417369 AY390426 AW662829 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A43 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                          -                       -                                                               
    SP2:                          -                       -                 -                                             
    SP3:                          -                       -                 -                                             
    SP4:                          -                       -                 -                             -               
    SP5:                                      -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for CYP3A43

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP3A43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCATTTGT
    CYP3A43 Expression
    About this image


    See CYP3A43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP3A43

    SOURCE GeneReport for Unigene cluster: Hs.306220

    UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
    Tissue specificity: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver
    and fetal skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including CYP3A43: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CYP3A43 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp3a575
    Cyp3a251
    cytochrome P450, family 3, subfamily a, polypeptide more1, 5 74.3(n)1
    66.53(a)1
      5 (85.17 cM)5
    563881  NM_019792.21  NP_062766.21 
     1453452795 
    chicken
    (Gallus gallus)
    Aves CYP3A46
    CYP3A76
    cytochrome P450 A 37
    55(a)
    55(a)
    possible ortholog
    1 ↔ many
    14(3884372-3894819)
    14(3919206-3928547)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    59(a)
    55(a)
    (see all 4)
    possible ortholog
    many ↔ many
    (see all 4)
    GL343987.1(68581-71922)
    GL343591.1(16157-77793)
    zebrafish
    (Danio rerio)
    Actinopterygii BC052130.12   -- 72.92(n)    BC052130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp6g13
    Cyp9f21
    DDT resistance cytochrome P4503
    CG11466-PA1
    33(a)
    (best of 34)3
    47.29(n)1
    35.79(a)1
      2 48E73
    415201  NM_141932.21  NP_650189.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T10B9.13 cytochrome P450 30(a)
    (best of 14)
      II(9795758-9797650)   --


    ENSEMBL Gene Tree for CYP3A43 (if available)
    TreeFam Gene Tree for CYP3A43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP3A43 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A42  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    18 SIMAP similar genes for CYP3A43 using alignment to 12 protein entries:     CP343_HUMAN (see all proteins):
    CYP3A7    C8orf17    CYP3A43/CYP3A4    CYP3A5    CYP3A4    CYP46A1
    CYP4A11    CYP2U1    TBXAS1    CYP19A1    CYP2R1    CYP4B1
    thromboxane synthase    CYP2D6    CYP1A1    CYP2E1    CYP2C9    CYP26B1

    CYP3A43 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
    Polymorphism: At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is
    that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional


    10/908 SNPs in CYP3A43 are shown (see all 908)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507474641,2
    C--98816109(+) TGCTG-/TATTATTA
    TTATTATTAT
    TATTA
    3 -- int10--------
    rs1510112041,2
    C--98816109(+) TGCTG-/TATTATTATTATTA
    TTATTATTATTATTAT
    TATTA
    3 -- int10--------
    rs2015163021,2
    C--98816109(+) TGCTG-/TATTAT
            
    TATTA
    3 -- int10--------
    rs341077141,2
    C--98822726(+) TTGGG-/TAGAAT 3 -- int10--------
    rs601756491,2
    C--99430947(+) GGGGG-/GGAGATC 3 -- int10--------
    rs30322511,2
    C--99451116(+) CTCTT-/TTT   
      
    /TTTTT
    ATTTC
    6 -- int1 cds11CSA 2
    rs558923041,2
    C--99456332(+) TTATT-/ATT/ATTATT/ATTATTATTA
    TTATT
    /ATTATTATTATTATTATT
    TGAGA
    15 -- int1 cds11NA 2
    rs1387220001,2
    --102727647(+) ACCCAC/GCCAGT 3 -- us2k10--------
    rs1492955281,2
    --102727749(+) GGTAAA/GAAGGG 3 -- us2k10--------
    rs1445266591,2
    --102727759(+) GAAAAA/GTGGAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP3A43 (99425636 - 99464173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP3A43:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670223CNV Deletion23128226
    esv29538CNV Loss19812545


    Human Gene Mutation Database (HGMD): CYP3A43

    Locus Specific Mutation Databases (LSDB): CYP3A43
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A43
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606534    OMIM disorders: --

    17 diseases for CYP3A43:    About MalaCards
    fascioliasis    human immunodeficiency virus infectious disease    toxic encephalopathy    antley-bixler syndrome
    constipation    cytochrome p450    aspergillosis    porphyria
    candidiasis    diarrhea    brain disease    cholestasis
    hypercholesterolemia    skin disease    prostate cancer    lung cancer
    prostatitis


    CYP3A43 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CYP3A43
    Human Genome Epidemiology (HuGE) Navigator: CYP3A43 (12 documents)

    Export disorders for CYP3A43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP3A43 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CYP3A43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (PubMed id 11160876)1, 2, 3, 9 Domanski T.L.... Zaphiropoulos P.G. (2001)
    2. First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. (PubMed id 14695544)1, 2, 4, 9 Cauffiez C.... Broly F. (2004)
    3. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PubMed id 11266076)1, 2, 3, 9 Gellner K....Wojnowski L. (2001)
    4. Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia. (PubMed id 16848237)1, 4, 9 Shchepotina E.G....Lyakhovich V.V. (2005)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    6. A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (2009)
    7. Joint effects of inflammation and androgen metabolism on prostate cancer severity. (PubMed id 18566991)1, 4 Rebbeck T.R....Zeigler-Johnson C. (2008)
    8. CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians. (PubMed id 15894682)1, 4 Stone A....Lang N.P. (2005)
    9. CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. (PubMed id 15548719)1, 4 Zeigler-Johnson C....Rebbeck T.R. (2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64816 HGNC: 17450 AceView: CYP3A43 Ensembl:ENSG00000021461 euGenes: HUgn64816
    ECgene: CYP3A43 Kegg: 64816 H-InvDB: CYP3A43

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP3A43 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp3a43.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP3A43 gene:
    Search GeneIP for patents involving CYP3A43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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