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CYP3A43 Gene

protein-coding   GIFtS: 62
GCID: GC07P099426

Cytochrome P450, Family 3, Subfamily A, Polypeptide 43

(Previous names: cytochrome P450, subfamily IIIA, polypeptide 43)
  Search for CYP3A43
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 431 2
Cytochrome P450, Subfamily IIIA, Polypeptide 431 2
EC 1.14.14.13 8
Cytochrome P450 3A432

External Ids:    HGNC: 174501   Entrez Gene: 648162   Ensembl: ENSG000000214617   OMIM: 6065345   UniProtKB: Q9HB553   

Export aliases for CYP3A43 gene to outside databases

Previous GC identifers: GC07P097960 GC07P099023 GC07P099037 GC07P099070 GC07P099263 GC07P094062


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP3A43 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role
in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome
7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2013)

GeneCards Summary for CYP3A43 Gene:
CYP3A43 (cytochrome P450, family 3, subfamily A, polypeptide 43) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
Function: Exhibits low testosterone 6-beta-hydroxylase activity

Gene Wiki entry for CYP3A43 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP3A43 gene promoter:
         CHOP-10   PPAR-gamma1   PPAR-gamma2   Ik-3   GATA-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP3A43 promoter sequence
   Search Chromatin IP Primers for CYP3A43

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.1

CYP3A43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A43 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099426:  view genomic region     (about GC identifiers)

Start:
99,425,636 bp from pter      End:
99,464,173 bp from pter
Size:
38,538 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,785,456-98,823,992     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55 (See protein sequence)
Recommended Name: Cytochrome P450 3A43  
Size: 503 amino acids; 57670 Da
Cofactor: Heme group (By similarity)
Miscellaneous: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct
sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4
chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13,
CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The
longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while
a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts
exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined
in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver
(PubMed:11726664)
Secondary accessions: Q75MK2 Q9HB52 Q9HB53 Q9HB54 Q9HB57
Alternative splicing: 4 isoforms:  Q9HB55-1   Q9HB55-2   Q9HB55-3   Q9HB55-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CYP3A43: NX_Q9HB55

Explore proteomics data for CYP3A43 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP3A43 (Q9HB55) (see all 8)
     PGPTPLP  KESRLKD  LFPFLTP  EEWKRIR 


    See CYP3A43 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265850.1  NP_073731.1  NP_476436.1  NP_476437.1  

    ENSEMBL proteins: 
     ENSP00000346887   ENSP00000415221   ENSP00000416581   ENSP00000405557   ENSP00000401521  
     ENSP00000400316   ENSP00000411653   ENSP00000312110   ENSP00000222382   ENSP00000397332  
     ENSP00000345351  
    Reactome Protein details: Q9HB55

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A43
    CYP3 family

    4 InterPro protein domains:
     IPR008072 Cyt_P450_E_CYP3A
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002402 Cyt_P450_E_grp-II

    Graphical View of Domain Structure for InterPro Entry Q9HB55

    ProtoNet protein and cluster: Q9HB55

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008072 CYP3A P450 family signature


    UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP3A43           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP343_HUMAN, Q9HB55
    Function: Exhibits low testosterone 6-beta-hydroxylase activity
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By rifampicin

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ISS--
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
    GO:0070330aromatase activity IEA--
         
    Find genes that share ontologies with CYP3A43           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cyp3a57):
     no phenotypic analysis 

    Find genes that share phenotypes with CYP3A43           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP343_HUMAN, Q9HB55: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with CYP3A43           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP3A43 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Miscellaneous substrates0.00
    cytochrome P4500.74
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    4Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with CYP3A43           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP3A43
        cytochrome P450
    metapathway biotransformation

    2 Reactome Pathways for CYP3A43
        Miscellaneous substrates
    Xenobiotics


    1 Kegg Pathway  (Kegg details for CYP3A43):
        Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP3A43: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP3A43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP3A43 (ENSP000002223824) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALOX15ENSP000002937614STRING: ENSP00000293761
    CES2ENSP000003178424STRING: ENSP00000317842
    CES5AENSP000002905674STRING: ENSP00000290567
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYP3A43 (CP343)

    Selected HMDB Compounds for CYP3A43 (see all 50)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    10 DrugBank Compounds for CYP3A43    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DexamethasoneDesametasone (see all 9)50-02-2enzymeinducer19934256
    EthosuximideAethosuximide (see all 5)77-67-8enzymesubstrate19934256
    OxazepamOxazipam (see all 3)604-75-1enzymesubstrate19934256
    Phenelzine-- 51-71-8enzymeinhibitor19934256
    Praziquantel-- 55268-74-1enzymesubstrate19934256
    RifampinRFP (see all 3)13292-46-1enzymeinducer19934256
    Rifapentine-- 61379-65-5enzymeinducer19934256
    TestosteroneTES (see all 9)58-22-0enzymesubstrate19934256
    TroleandomycinOleandocetine (see all 5)2751-09-9enzymeinducer11095572
    ZalcitabineDDC (see all 3)7481-89-2enzymesubstrate19934256



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP3A43 gene (4 alternative transcripts): 
    NM_001278921.1  NM_022820.4  NM_057095.2  NM_057096.3  

    Unigene Cluster for CYP3A43:

    Cytochrome P450, family 3, subfamily A, polypeptide 43
    Hs.306220  [show with all ESTs]
    Unigene Representative Sequence: NM_022820
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354829(uc003urx.1 uc003ury.1 uc003urz.1 uc003usa.1 uc010lgi.1)
    ENST00000436834 ENST00000417625 ENST00000463915 ENST00000444905 ENST00000415413
    ENST00000477658 ENST00000495115 ENST00000433277 ENST00000491648 ENST00000481362
    ENST00000434806 ENST00000312017 ENST00000222382 ENST00000472352 ENST00000421837
    ENST00000342499(uc003usb.1)
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    Additional mRNA sequence: 

    AF280108.1 AF280109.1 AF280110.1 AF280111.1 AF280112.1 AF280113.1 AF319634.1 AF337813.1 
    AY390423.1 AY390424.1 AY390425.1 AY390426.1 BC100981.3 BC100982.3 

    3 DOTS entries:

    DT.104214  DT.100745110  DT.99960925 

    20 AceView cDNA sequences:

    BX092633 AF280112 AF280108 AY390424 NM_022820 AF319634 AF280109 NM_057096 
    AY390423 AF280111 AY390425 NM_057095 AF280113 AA417369 AA416822 AF280110 
    BX951468 AF337813 AW662829 AY390426 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A43 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                          -                       -                                                               
    SP2:                          -                       -                 -                                             
    SP3:                          -                       -                 -                                             
    SP4:                          -                       -                 -                             -               
    SP5:                                      -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for CYP3A43

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP3A43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCATTTGT
    CYP3A43 Expression
    About this image

    CYP3A43 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP3A43 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306220

    UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55
    Tissue specificity: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver
    and fetal skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP3A43: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP3A43 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp3a575 cytochrome P450, family 3, subfamily a, polypeptide more   --   5 (85.17 cM) 145345279 
    chicken
    (Gallus gallus)
    Aves CYP3A376
    Gallus gallus cytochrome P450 A 37 (CYP3A7), mRNA....
    55(a)
    1 → many
    14(3919206-3928547) ENSGALG00000004449
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    47(a)
    many ↔ many
    many ↔ many
    GL343591.1(16157-77793)
    GL343987.1(113184-127496)
    zebrafish
    (Danio rerio)
    Actinopterygii BC052130.12   -- 72.92(n)    BC052130.1 


    ENSEMBL Gene Tree for CYP3A43 (if available)
    TreeFam Gene Tree for CYP3A43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP3A43 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A42  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    18 SIMAP similar genes for CYP3A43 using alignment to 12 protein entries:     CP343_HUMAN (see all proteins):
    CYP3A7    C8orf17    CYP3A43/CYP3A4    CYP3A5    CYP3A4    CYP46A1
    CYP4A11    CYP2U1    TBXAS1    CYP19A1    CYP2R1    CYP4B1
    thromboxane synthase    CYP2D6    CYP1A1    CYP2E1    CYP2C9    CYP26B1

    Find genes that share paralogs with CYP3A43           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CP343_HUMAN, Q9HB55: At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is
    that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional


    Selected SNPs for CYP3A43 (see all 908)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507474641,2
    C--98816109(+) TGCTG-/TATTATTA
    TTATTATTAT
    TATTA
    3 -- int10--------
    rs1510112041,2
    C--98816109(+) TGCTG-/TATTATTATTATTA
    TTATTATTATTATTAT
    TATTA
    3 -- int10--------
    rs2015163021,2
    C--98816109(+) TGCTG-/TATTAT
            
    TATTA
    3 -- int10--------
    rs341077141,2
    C--98822726(+) TTGGG-/TAGAAT 3 -- int10--------
    rs601756491,2
    C--99430947(+) GGGGG-/GGAGATC 3 -- int10--------
    rs30322511,2
    C--99451116(+) CTCTT-/TTT   
      
    /TTTTT
    ATTTC
    6 -- int1 cds11CSA 2
    rs558923041,2
    C--99456332(+) TTATT-/ATT/ATTATT/ATTATTATTA
    TTATT
    /ATTATTATTATTATTATT
    TGAGA
    15 -- int1 cds11NA 2
    rs1387220001,2
    --102727647(+) ACCCAC/GCCAGT 3 -- us2k10--------
    rs1492955281,2
    --102727749(+) GGTAAA/GAAGGG 3 -- us2k10--------
    rs1445266591,2
    --102727759(+) GAAAAA/GTGGAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP3A43 (99425636 - 99464173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP3A43:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670223CNV Deletion23128226
    esv29538CNV Loss19812545

    The Human Cytochrome P450 Allele Nomenclature Database: CYP3A43 
    Human Gene Mutation Database (HGMD): CYP3A43
    Locus Specific Mutation Databases (LSDB): CYP3A43

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A43
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606534    OMIM disorders: --


    Find genes that share disorders with CYP3A43           About GenesLikeMe

    Genetic Association Database (GAD): CYP3A43
    Human Genome Epidemiology (HuGE) Navigator: CYP3A43 (12 documents)

    Export disorders for CYP3A43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP3A43 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CYP3A43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (PubMed id 11160876)1, 2, 3, 9 Domanski T.L.... Zaphiropoulos P.G. (Mol. Pharmacol. 2001)
    2. First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. (PubMed id 14695544)1, 2, 4, 9 Cauffiez C.... Broly F. (Hum. Mutat. 2004)
    3. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PubMed id 11266076)1, 2, 3, 9 Gellner K....Wojnowski L. (Pharmacogenetics 2001)
    4. Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia. (PubMed id 16848237)1, 4, 9 Shchepotina E.G....Lyakhovich V.V. (Bull. Exp. Biol. Med. 2005)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    7. Joint effects of inflammation and androgen metabolism on prostate cancer severity. (PubMed id 18566991)1, 4 Rebbeck T.R....Zeigler-Johnson C. (Int. J. Cancer 2008)
    8. CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians. (PubMed id 15894682)1, 4 Stone A....Lang N.P. (amp 2005)
    9. CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. (PubMed id 15548719)1, 4 Zeigler-Johnson C....Rebbeck T.R. (Cancer Res. 2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64816 HGNC: 17450 AceView: CYP3A43 Ensembl:ENSG00000021461 euGenes: HUgn64816
    ECgene: CYP3A43 Kegg: 64816 H-InvDB: CYP3A43

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP3A43 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp3a43.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP3A43 gene:
    Search GeneIP for patents involving CYP3A43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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