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CYP3A4 Gene

protein-coding GIFtS: 68

GC07M099192

cytochrome P450, family 3, subfamily A, polypeptide 4
(Previous names: cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP3A3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CP33 ^²
CP34 ^²
CYP3A ^²
CYP3A3 ^², ³
CYPIIIA3 ^³
CYPIIIA4 ^³
EC 1.14.13.67,EC 1.14.13.97,EC 1.14.13.32 ^³
HLP ^²
HLp ^³
MGC126680 ^²
NF-25 ^², ³
P450-PCN1 ^³
P450C3 ^²
P450PCN1 ^²

Descriptions
Albendazole monooxygenase ^³
Albendazole sulfoxidase ^³
Cytochrome P450 3A3 ^³
Nifedipine oxidase ^², ³
P450-III, steroid inducible ^²
Quinine 3-monooxygenase ^³
Taurochenodeoxycholate 6-alpha-hydroxylase ^³
cytochrome P450, family 3, subfamily A, polypeptide 4 ^²
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 ^²
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 ^¹, ²
glucocorticoid-inducible P450 ^²

External Ids
HGNC: 2637¹
Entrez Gene: 1576²
UniProtKB: P08684³
Ensembl: ENSG00000160868⁷

Search outside databases for aliases for CYP3A4 gene

Previous GC identifers: GC07M097889 GC07M098952 GC07M098967 GC07M098968 GC07M098892 GC07M098999

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CYP3A4:

This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome

P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and

synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic

reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This

enzyme is involved in the metabolism of approximately half the drugs which are are used today,

including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also

metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes

on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is

now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]

UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this

enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of

oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam

1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide

Gene Wiki entry for CYP3A4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CYP3A4 gene

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.1

CYP3A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M099192: (about GC identifiers)

Start:	99,192,540 bp from pter
End:	99,219,744 bp from pter
Size:	27,205 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 98,714,417-98,741,612

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684 (See protein sequence)

Recommended Name: Cytochrome P450 3A4

Size: 503 amino acids; 57343 Da

Cofactor: Heme group

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome

membrane; Single-pass membrane protein

PDB structures from and Proteopedia :

1TQN (3D)

1W0E (3D)

1W0F (3D)

1W0G (3D)

2J0D (3D)

2V0M (3D)

Secondary accessions: P05184 Q16757 Q9UK50

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_059488.2

ENSEMBL proteins:

ENSP00000337915 ENSP00000346607

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for CYP3A4
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cytochrome P450 3A4 )
	Human Recombinant Proteins from Abnova (CYP3A4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	TAS	3460094
GO:0009986	cell surface	IDA	12493773
GO:0016020	membrane	IEA	--

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Antibodies for CYP3A4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CYP3A4
	Sigma-Aldrich Antibodies for CYP3A4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cytochrome P450 3A4 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CYP3A4)
	Novus Biologicals Antibodies for CYP3A4

Assays for CYP3A4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08684

ProtoNet protein and cluster: P08684

3 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB002402 Group II E-class P450 signature

IPB008072 CYP3A P450 family signature

UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684

Similarity: Belongs to the cytochrome P450 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP3A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP3A4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017460

Applied Biosystems Silencer® siRNAs for CYP3A4

Sigma-Aldrich siRNA and siRNA Panels for CYP3A4

Sigma-Aldrich shRNA for CYP3A4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CYP3A4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017460
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017460
untagged cDNA clone in CMV expression vector: NM_017460

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017460

UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this

enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of

oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam

1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide

Catalytic activity: Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O

Catalytic activity: Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O

Catalytic activity: Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O

Catalytic activity: Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O

Induction: By glucocorticoids. Also induced to high levels in liver and other tissues by various

foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Number (IUBMB): EC 1.14.13.67,EC

Genatlas biochemistry entry for CYP3A4:

cytochrome P450,family III,polypeptide 4 (niphedipine oxidase);highly expressed in the liver,see

CYP3A@,with a significant association of the wild type enzyme with epipodophyllotoxin-induced

leukemogenesis

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009055	electron carrier activity	IEA	--
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	--
GO:0019825	oxygen binding	TAS	2492107 3460094
GO:0020037	heme binding	IEA	--
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for CYP3A4 (Your Favorite Gene powered by Ingenuity) (see all 9 )

Arachidonic Acid Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Xenobiotic Metabolism Signaling
Linoleic Acid Metabolism
Tryptophan Metabolism

GeneDecks CYP3A4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CYP3A4

5/98 Interacting proteins for CYP3A4 (ENSP00000337915³) via UniProtKB, MINT, and/or STRING (see all 98 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR1I2	ENSP00000336528³	STRING (score=.99)
GSTT1	ENSP00000248935³	STRING (score=.981)
GSTP1	ENSP00000196968³	STRING (score=.98)
UGT2B7	ENSP00000304811³	STRING (score=.98)
EPHX1	ENSP00000355802³	STRING (score=.975)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	2492107
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CYP3A4

Sigma-Aldrich Small Molecules for CYP3A4:

Inhibitor

Browse Tocris compounds for CYP3A4
10/45 Novoseek chemical compound relationships for CYP3A4 gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1-hydroxymidazolam	87.77	17	8185679 (4), 15801939 (2), 10741627 (1), 8669558 (1) (see all 11)
citco	86.20	10	17585873 (1), 18347084 (1), 19202563 (1)
androstane	86.16	24	16513849 (2), 17392393 (2), 17041008 (2), 15466163 (1) (see all 21)
6beta-hydroxycortisol	84.92	36	9753209 (2), 14605865 (2), 15298747 (2), 10463384 (2) (see all 22)
6beta-hydroxytestosterone	84.32	11	17581220 (1), 18094037 (1), 15037195 (1), 10497147 (1) (see all 8)
alpha-naphthoflavone	81.16	34	17459328 (4), 10548449 (3), 10022752 (2), 9473295 (1) (see all 14)
4-hydroxymidazolam	79.60	6	8185679 (4), 15735612 (1)
lapachenole	78.41	3	16959210 (1), 15697209 (1), 15697210 (1)
7-benzyloxyquinoline	77.96	6	11602524 (2), 15870379 (1)
norcisapride	75.87	4	11717173 (2), 10859153 (1), 11454912 (1)

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10/34 PharmGKB drug compound relationships for CYP3A4 gene (see all 34 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
alprazolam	PK	12196913
anthracycline	CO GN	12439220
asparaginase	CO	15713801
cisapride	PK FA	11717173
citalopram	PK FA	9110356 12975335
codeine	PK GN	15625333
cytarabine	CO	15713801
daunorubicin	CO	15713801
dexamethasone	PK FA	8114683
docetaxel	PK	15116057

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP3A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP3A4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017460

Sigma-Aldrich siRNA and siRNA Panels for CYP3A4

Sigma-Aldrich shRNA for CYP3A4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017460

REFSEQ mRNAs for CYP3A4 gene:

NM_017460.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017460

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017460
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017460
                                 untagged cDNA clone in CMV expression vector: NM_017460

Additional cDNA sequence:

AF182273.1 AJ563375.1 AJ563376.1 AJ563377.1 AK298451.1 AK298462.1 AK312967.1 AY606313.2

BC069352.1 BC069418.1 BC101631.1 DQ924960.1 M13785.1 M14096.1 M18907.1 X12387.1

19 DOTS entries:

DT.86852386 DT.91933736 DT.92456503 DT.86855768 DT.100808524 DT.100808520 DT.92456533 DT.100775927

DT.100808527 DT.91804891 DT.95370344 DT.92456519 DT.100643862 DT.100742103 DT.92456530 DT.100775926

DT.102845494 DT.313245 DT.95370347

24/189 AceView cDNA sequences (see all 189 ):

BG194899 CB156859 AV648960 BG215637 AV650291 AV657487 AV659157 AV650321

NM_017460 CB157183 AV646885 BG206682 CB157627 AV654109 AV647087 AV650252

BG194898 BG220280 CB164067 AV660672 AV659777 AV648762 CB157672 T27857

highest scoring ESTs for CYP3A4:

AV655749 AF182273 AU076847 AV655529 AV657487 AV657523 AV660310 BC069352 BC069418 BX506284

Unigene Cluster for CYP3A4:

Cytochrome P450, family 3, subfamily A, polypeptide 4

Hs.654391 [show with all ESTs]

Unigene Representative Sequence: NM_017460

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000336411 ENST00000354593

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CYP3A4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP3A4

¹ / ² / ³

11 probe-sets matching CYP3A4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1755_i_at²^{, 3}	U95-A	1	1.00	1.00	-0.20	0.14	D00003	0.60	0.83	0.73	1
270_at²^{, 3}	U95-A	1	1.00	1.00	0.61	0.29	J04449	0.80	0.68	0.74	1
1756_f_at²^{, 3}	U95-A	4	1.00	0.69	1.00	1.00	D00003	0.60	0.83	0.73	1
210726_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J04449	0.80	0.68	0.74	1
208367_x_at²^{, 3}	U133-A	3	1.00	0.89	--	--	NM_000776	0.20	1.00	0.72	1
205998_x_at²^{, 3}	U133-A	35	1.00	0.80	--	--	NM_017460	0.60	0.73	0.67	1
205999_x_at²^{, 3}	U133-A	4	1.00	0.70	--	--	AF182273	0.80	0.68	0.74	1
210726_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208367_x_at²	U133Plus2	3	1.00	0.89	--	--	--	--	--	--	--
205998_x_at²	U133Plus2	35	1.00	0.80	--	--	--	--	--	--	--
205999_x_at²	U133Plus2	4	1.00	0.70	--	--	--	--	--	--	--

GeneDecks CYP3A4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.654391
Expression variation in blood from EXPOLDB for CYP3A4
UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684
Tissue specificity: Expressed in prostate and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CYP3A4 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC479740¹	--	hypothetical LOC479740	84.56(n) 80.52(a)	479740 XM_536868.2 XP_536868.2
chimpanzee (Pan troglodytes)	CYP3A4¹	--	cytochrome P450, family 3, subfamily A, polypeptide more	99.4(n) 98.41(a)	463582 XM_001142380.1 XP_001142380.1
cow (Bos taurus)	CYP3A4¹	--	cytochrome P450, subfamily IIIA (niphedipine oxidase), more	81.45(n) 72.98(a)	282214 NM_174531.2 NP_776956.2
rat (Rattus norvegicus)	Cyp3a1¹	--	cytochrome P450, family 3, subfamily a, polypeptide more	78.26(n) 73.56(a)	286929 NM_173144.1 NP_775167.1
mouse (Mus musculus)	Cyp3a11¹	--	cytochrome P450, family 3, subfamily a, polypeptide more	78.13(n) 72.76(a)	13112 NM_007818.3 NP_031844.1

About this table Species with no ortholog for CYP3A4

ENSEMBL Gene Tree for CYP3A4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CYP3A4 gene

TBXAS1² CYP3A5² CYP3A43² CYP3A7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/322 NCBI SNPs in CYP3A4 are shown (see all 322 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 113)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1851426^1,2	A,C,F,H,O	99220872(-)	`TCTTAC/TTGGAG`	1	--	ng3¹		21	NA NS EU EA WA MN CSAM	1564
--	rs12333983^1,2	A,C,F,H	99192050(+)	`cacggT/Atacat`	1	--	ng5¹		9	EU EA WA NS	608
--	rs2740574^1,2	A,C,F,H	99220032(-)	`GGGCAA/GGAGAG`	1	--	ng3¹ trp³		25	CSA EU CSAM NA MN EA WA NS	2368
--	rs12721631^1,2	C,F,H	99193363(-)	`AATTTC/TCTCCA`	1	--	ut3¹		10	MN CSAM EA EU WA	1006
	rs11773597^1,2	C,F,H	99220387(+)	`ACCAGG/CGTGCT`	1	--	ng3¹		9	EU EA WA NS	584
--	rs12721626^1,2	C,F,H	99193214(-)	`CTGCAC/TATTAA`	1	--	ut3¹		10	MN CSAM EA EU WA	996
	rs4986910^1,2	C,F,H	99196460(-)	`TGGCAT/CGAGGT`	1	T/M	mis¹ ese³		16	MN CSAM EA NS EU WA	1330
	rs4986907^1,2	C,F,H	99205363(-)	`GAGGCG/AGGAAG`	1	Q/R	mis¹		16	MN CSAM EA NS EU NA	1512
	rs12721636^1,2	C,F,H	99219702(-)	`CCCAGC/AAAAGA`	1	--	ut5¹		10	MN CSAM EA EU WA	1202
	rs28371763^1,2	C,F	99192744(-)	`AAAAAA/TATATG`	1	--	ut3¹		11	NS MN CSAM EA	792

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HapMap Linkage Disequilibrium images for CYP3A4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 124010

10/87 Novoseek disease relationships for CYP3A4 gene (see all 87 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acetaminophen metabolism	54.38	1	10678302 (1)
rhabdomyolysis	45.73	4	11856903 (1), 16581331 (1), 11149552 (1)
colon carcinoma	34.80	18	12419308 (2), 14615069 (2), 12625868 (2), 12738030 (1) (see all 13)
immunodeficiency	27.49	14	12189360 (1), 15657782 (1), 16433896 (1), 14985144 (1) (see all 11)
torsades de pointes	25.94	5	15762770 (1), 9545159 (1), 12949438 (1)
liver dysfunction	17.82	2	12867215 (1), 18183036 (1)
cholestasis	17.15	5	15454728 (1), 16455805 (1), 15726657 (1), 15708356 (1)
myopathy	16.81	7	10513779 (3), 12904106 (1), 16581331 (1), 15843281 (1)
xanthomatosis cerebrotendinous	16.58	1	12509506 (1)
liver diseases	16.25	3	7741759 (1), 9131486 (1), 9927612 (1)

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10/10 PharmGKB disease relationships for CYP3A4 gene (see all 10 )

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	PK FA	12971802
Hepatitis C, Chronic	PK	12087352
Leukemia	PD GN	9789061
Leukemia, Lymphocytic, Acute, L1	CO GN	12439220 15713801
Leukemia, Myeloid	CO GN	12439220
Migraine	CO PD PK	14511273
Neoplasms	PK	15116057
Prostatic Neoplasms	PD GN	9719084
Rhabdomyolysis	PK	15518608
helicobacter pylori, gastric ulcers	PD PK	11925851

About this table

Human Gene Mutation Database: CYP3A4
Genetic Association Database: CYP3A4
Human Genome Epidemiology Navigator: CYP3A4 (242 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1275 PubMed articles for CYP3A4 gene (see all 1275 ):

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. (PubMed id 11875366)^{1, 3, 4, 7} Lamba J.K.... Schuetz E.G. (2002)
Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies. (PubMed id 12439220)^{1, 3, 6, 7} Blanco J.G....Relling M.V. (2002)
Association of CYP3A4 genotype with treatment-related leukemia. (PubMed id 9789061)^{1, 3, 6, 7} Felix C.A....Rebbeck T.R. (1998)
Pharmacokinetics of citalopram in relation to genetic polymorphism of CYP2C19. (PubMed id 12975335)^{3, 6, 7} Yu B.N....Zhou H.H. (2003)
CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity. (PubMed id 11907494)^{3, 6, 7} Garcia-Martin E....Agundez J.A. (2002)
Novel mutations of CYP3A4 in Chinese. (PubMed id 11181494)^{3, 4, 6} Hsieh K.-P.... Huang J.-D. (2001)
Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. (PubMed id 11714865)^{3, 4, 6} Dai D.... Goldstein J.A. (2001)
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. (PubMed id 10668853)^{3, 4, 7} Sata F.... Gonzalez F.J. (2000)
Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients. (PubMed id 16243813)^{1, 3, 6} Lepper E.R....Sparreboom A. (2005)
The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. (PubMed id 16321621)^{1, 3, 6} Fiegenbaum M....Hutz M.H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1576	HGNC: 2637	AceView: CYP3A4	Ensembl:ENSG00000160868	euGenes: HUgn1576
ECgene: CYP3A4	H-InvDB: CYP3A4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CYP3A4	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp3a4.htm
Wikipedia	http://en.wikipedia.org/wiki/CYP3A4

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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CYP3A4 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CYP3A4

Summaries
for CYP3A4

Genomic Location
for CYP3A4

Proteins
for CYP3A4

Protein Domains/
Families
for CYP3A4

Gene Function
for CYP3A4

Pathways & Interactions
for CYP3A4

Drugs & Compounds
for CYP3A4

Transcripts
for CYP3A4

Expression
for CYP3A4

Orthologs
for CYP3A4

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for CYP3A4

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CYP3A4 (Gene Symbol)
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
EC 1.14.13.67,EC 1.14.13.97,EC 1.14.13.32
HLP
HLp
MGC126680
NF-25
P450-PCN1
P450C3
P450PCN1
Albendazole monooxygenase
Albendazole sulfoxidase
Cytochrome P450 3A3
Nifedipine oxidase
P450-III, steroid inducible
Quinine 3-monooxygenase
Taurochenodeoxycholate 6-alpha-hydroxylase
cytochrome P450, family 3, subfamily A, polypeptide 4
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
glucocorticoid-inducible P450

CYP3A4 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CYP3A4

Summariesfor CYP3A4

Genomic Locationfor CYP3A4

Proteinsfor CYP3A4

Protein Domains/Familiesfor CYP3A4

Gene Functionfor CYP3A4

Pathways & Interactionsfor CYP3A4

Drugs & Compoundsfor CYP3A4

Transcriptsfor CYP3A4

Expression for CYP3A4

Orthologsfor CYP3A4

Paralogsfor CYP3A4

SNPs/Variantsfor CYP3A4

Disorders & Mutationsfor CYP3A4

Medical Newsfor CYP3A4

Publicationsfor CYP3A4

Search for CYP3A4

Genome Databases showing CYP3A4

Other Databases showing CYP3A4

Specialized Databases showing CYP3A4

Licensable Technologiesfor CYP3A4

Servicesfor CYP3A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CYP3A4

Summaries
for CYP3A4

Genomic Location
for CYP3A4

Proteins
for CYP3A4

Protein Domains/
Families
for CYP3A4

Gene Function
for CYP3A4

Pathways & Interactions
for CYP3A4

Drugs & Compounds
for CYP3A4

Transcripts
for CYP3A4

Expression
for CYP3A4

Orthologs
for CYP3A4

Paralogs
for CYP3A4

SNPs/Variants
for CYP3A4

Disorders & Mutations
for CYP3A4

Medical News
for CYP3A4

Publications
for CYP3A4

Licensable Technologies
for CYP3A4

Services
for CYP3A4