Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CYP3A4 Gene

protein-coding   GIFtS: 69
GCID: GC07M099355

Cytochrome P450, Family 3, Subfamily A, Polypeptide 4

(Previous names: cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide...)
(Previous symbol: CYP3A3)
  See CYP3A4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome P450, Family 3, Subfamily A, Polypeptide 41 2     CP342
CYP3A31 2 3     CYP3A2
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 41 2     HLP2
Albendazole Monooxygenase2 3     NF-252
Albendazole Sulfoxidase2 3     P450C32
Cytochrome P450 3A32 3     P450PCN12
Cytochrome P450 HLp2 3     Cytochrome P450 3A42
Cytochrome P450 NF-252 3     Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 32
Cytochrome P450-PCN12 3     Glucocorticoid-Inducible P4502
Nifedipine Oxidase2 3     P450-III, Steroid Inducible2
Quinine 3-Monooxygenase2 3     EC 1.14.13.-3
Taurochenodeoxycholate 6-Alpha-Hydroxylase2 3     EC 1.14.13.1573
1,8-Cineole 2-Exo-Monooxygenase2 3     EC 1.14.13.323
CYPIIIA32 3     EC 1.14.13.673
CYPIIIA42 3     EC 1.14.13.973
CP332     EC 1.14.14.18

External Ids:    HGNC: 26371   Entrez Gene: 15762   Ensembl: ENSG000001608687   OMIM: 1240105   UniProtKB: P086843   

Export aliases for CYP3A4 gene to outside databases

Previous GC identifers: GC07M097889 GC07M098952 GC07M098967 GC07M098968 GC07M098892 GC07M098999 GC07M099192 GC07M093991


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CYP3A4 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half
the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme
also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on
chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that
this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Feb 2011)

GeneCards Summary for CYP3A4 Gene:
CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) is a protein-coding gene. Diseases associated with CYP3A4 include xanthomatosis, and methemoglobinemia. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP4F22.

UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g.
caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of
structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole
2-exo-monooxygenase. The enzyme also hydroxylates etoposide

summary for CYP3A4 Gene:
Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs
are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.
CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate
and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential
for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They
are found at high levels in the liver, where they have an important role in metabolism of drugs and
endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this
accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,
cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP3A4 Gene

PharmGKB "VIP" summary for CYP3A4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP3A4 gene promoter:
         GR   COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   GATA-6   COUP-TF   STAT3   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CYP3A4 promoter sequence
   Search Chromatin IP Primers for CYP3A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.1

CYP3A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP3A4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099355:  view genomic region     (about GC identifiers)

Start:
99,354,583 bp from pter      End:
99,381,888 bp from pter
Size:
27,306 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,714,396-98,741,615     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684 (See protein sequence)
Recommended Name: Cytochrome P450 3A4  
Size: 503 amino acids; 57343 Da
Cofactor: Heme group
Miscellaneous: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct
sets of CYP3A4 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts
exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in
frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform
(CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform
(CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. All chimeric transcripts are expressed at very low levels
in the liver (PubMed:11726664)
Selected PDB 3D structures from and Proteopedia for CYP3A4 (see all 17):
1TQN (3D)        1W0E (3D)        1W0F (3D)        1W0G (3D)        2J0D (3D)        2V0M (3D)    
Secondary accessions: P05184 Q16757 Q9UK50

Explore the universe of human proteins at neXtProt for CYP3A4: NX_P08684

Explore proteomics data for CYP3A4 at MOPED

Post-translational modifications: 

  • Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP3A4 (P08684) (see all 15)
     SVFTNRR  PGPTPLP  LLSPTFT  PTFTSGK 


    See CYP3A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001189784.1  NP_059488.2  

    ENSEMBL proteins: 
     ENSP00000337915   ENSP00000397208   ENSP00000346607  
    Reactome Protein details: P08684

    CYP3A4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CYP3A4
    OriGene Protein Over-expression Lysate for CYP3A4
    OriGene MassSpec for CYP3A4
    OriGene Custom Protein Services for CYP3A4
    GenScript Custom Purified and Recombinant Proteins Services for CYP3A4
    Novus Biologicals CYP3A4 Proteins
    Novus Biologicals CYP3A4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYP3A4

     
    Search eBioscience for Proteins for CYP3A4 

     
    antibodies-online proteins for CYP3A4 (8 products) 

     
    antibodies-online peptides for CYP3A4

    CYP3A4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP3A4
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CYP3A4 
    OriGene Antibodies for CYP3A4
    OriGene Custom Antibody Services for CYP3A4
    Novus Biologicals CYP3A4 Antibodies
    Abcam antibodies for CYP3A4
    Cloud-Clone Corp. Antibodies for CYP3A4
    ThermoFisher Antibody for CYP3A4
    LSBio Antibodies in human, mouse, rat for CYP3A4
    antibodies-online antibodies for CYP3A4 (83 products) 

    CYP3A4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYP3A4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYP3A4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYP3A4
    Cloud-Clone Corp. CLIAs for CYP3A4
    Search eBioscience for ELISAs for CYP3A4 
    antibodies-online kits for CYP3A4 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP3A4
    CYP3 family

    4 InterPro protein domains:
     IPR008072 Cyt_P450_E_CYP3A
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002402 Cyt_P450_E_grp-II

    Graphical View of Domain Structure for InterPro Entry P08684

    ProtoNet protein and cluster: P08684

    3 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB002402 Group II E-class P450 signature
    IPB008072 CYP3A P450 family signature


    UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP3A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP3A4_HUMAN, P08684
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g.
    caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of
    structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole
    2-exo-monooxygenase. The enzyme also hydroxylates etoposide
    Catalytic activity: Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O
    Catalytic activity: Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O
    Catalytic activity: Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O
    Catalytic activity: Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O
    Catalytic activity: 1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O
    Induction: By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign
    compounds, including drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP3A4:
    cytochrome P450,family III,polypeptide 4 (niphedipine oxidase);highly expressed in the liver,see CYP3A@,with a
    significant association of the wild type enzyme with epipodophyllotoxin-induced leukemogenesis

         Enzyme Numbers (IUBMB): EC 1.14.13.321 EC 1.14.13.1571 EC 1.14.14.12 EC 1.14.13.971 EC 1.14.13.-1 EC 1.14.13.671

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ISS--
    GO:0005496steroid binding IDA15256616
    GO:0005506iron ion binding IDA15256616
    GO:0008395steroid hydroxylase activity IMP18356043
    GO:0016491oxidoreductase activity IDA15039299
         
    Find genes that share ontologies with CYP3A4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP3A4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP3A4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP3A4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP3A4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYP3A4:
    hsa-mir-27b-3p (MIRT006510)

    Block miRNA regulation of human, mouse, rat CYP3A4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYP3A4 (see all 10):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-548b-5p
    SwitchGear 3'UTR luciferase reporter plasmidCYP3A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYP3A4
    Predesigned siRNA for gene silencing in human, mouse, rat CYP3A4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYP3A4

    Clone
    Products:
         
    OriGene clones in human, mouse for CYP3A4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CYP3A4 (NM_001202855)
    Sino Biological Human cDNA Clone for CYP3A4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP3A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP3A4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYP3A4
    Browse ESI BIO Cell Lines and PureStem Progenitors for CYP3A4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A4

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10196) for CYP3A4 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CP3A4_HUMAN, P08684: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane;
    Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus3
    cytosol2
    extracellular2
    plasma membrane2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18446064
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle TAS3460094

    Find genes that share ontologies with CYP3A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CYP3A4 About   (see all 33)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Biological oxidations
    Biological oxidations0.56
    Phenytoin Pathway, Pharmacokinetics0.00
    metapathway biotransformation0.42
    Sorafenib Pharmacokinetics0.00
    Benzo(a)pyrene metabolism0.00
    Tamoxifen metabolism0.00
    Benzodiazepine Pathway, Pharmacokinetics0.00
    Estradiol metabolism0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty Acid Omega Oxidation0.00
    Phase 1 - Functionalization of compounds0.75
    Cyclophosphamide Pathway, Pharmacokinetics0.00
    cytochrome P4500.74
    Ifosfamide Pathway, Pharmacokinetics0.00
    Xenobiotics0.00
    Vitamin D2 ergocalciferol metabolism0.00
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Aflatoxin B1 metabolism0.00
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    Drug metabolism - cytochrome P4500.69
    Celecoxib Pathway, Pharmacokinetics0.00
    Retinol metabolism0.35
    Artemisinin and Derivatives Pathway, Pharmacokinetics0.00
    4Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Taxane Pathway, Pharmacokinetics0.30
    5Codeine and Morphine Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics0.33
    Codeine and morphine metabolism0.00
    Tramadol Pharmacokinetics0.33


    Find genes that share SuperPaths with CYP3A4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CYP3A4
        Glucose / Energy Metabolism

    Selected GeneGo (Thomson Reuters) Pathways for CYP3A4 (see all 11)
        Estrogen biosynthesis
    Naphthalene metabolism
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Acetaminophen metabolism
    Estradiol metabolism

    Selected BioSystems Pathways for CYP3A4 (see all 13)
        Aflatoxin B1 metabolism
    cytochrome P450
    Codeine and morphine metabolism
    Irinotecan Pathway
    Tamoxifen metabolism


    1 Reactome Pathway for CYP3A4
        Xenobiotics

    Selected PharmGKB Pathways for CYP3A4 (see all 42)
        Acetaminophen Pathway, Pharmacokinetics
    Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
    Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
    Artemisinin and Derivatives Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP3A4) (see all 9):
        Steroid hormone biosynthesis
    Linoleic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP3A4: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP3A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP3A4 (P086843 ENSP000003379154) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    STUB1Q9UNE73, ENSP000002195484I2D: score=1 STRING: ENSP00000219548
    UGT2B7P166623, ENSP000003048114I2D: score=1 STRING: ENSP00000304811
    BYSLQ138953I2D: score=5 
    C9orf64Q5T6V53I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS2492107
    GO:0006706steroid catabolic process IMP18356043
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IMP3259858
    GO:0008209androgen metabolic process TAS19651758

    Find genes that share ontologies with CYP3A4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CYP3A4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4981517Selective CYP3A4 inhibitor[1390637-82-7]
    MethoxyresorufinFluorometric CYP450 substrate[5725-89-3]
    Letrozole Potent, reversible non-steroidal aromatase inhibitor [112809-51-5]
    ExemestaneSteroidal aromatase (CYP19) inhibitor[107868-30-4]
    PentoxyresorufinFluorometric cytochrome P450 substrate[87687-03-4]

    Selected HMDB Compounds for CYP3A4 (see all 67)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    15H-11,12-EETA15-Hydroxy-11,12-epoxyeicosatrienoic acid (see all 9)877878-78-9--
    16(R)-HETE16R-HETE (see all 4)----

    Selected DrugBank Compounds for CYP3A4 (see all 535)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clopidogrel-- 113665-84-2enzymesubstrate15679472 15604326 19934256 14707025 12925453 14522569 12485953 19515014
    Astemizole-- 68844-77-9enzymesubstrate inhibitor10597902 11259984 15133245 19934256 12662125 10592235 15684493
    MidazolamDea No. 2884 (see all 4)59467-70-8enzymesubstrate inhibitor12124305 15544435 12065442 9890159 20203109 12433827 19934256
    CerivastatinCerivastatin sodium (see all 2)145599-86-6enzymesubstrate inhibitor inducer17178259 12433802 11523064 9172950 19934256 19515014
    Ifosfamide-- 3778-73-2enzymesubstrate inhibitor inducer16702183 15919850 19934256 19515014 12136253 10348794
    Telithromycin-- 191114-48-4enzymesubstrate inhibitor16199242 15598962 15792396 12149046 11601667 19934256
    AmitriptylineAmitriprolidine (see all 5)50-48-6enzymesubstrate11259560 9131945 18359012 19934256 19515014
    Atorvastatin-- 134523-00-5enzymesubstrate inhibitor inducer17178259 11038166 11523064 19934256 19515014
    Citalopram-- 59729-33-8enzymesubstrate10774624 9890159 19934256 11532381 19515014
    Fluvastatin-- 93957-54-1enzymesubstrate inhibitor inducer11368292 19663817 19934256 10064574 19515014

    Selected Novoseek inferred chemical compound relationships for CYP3A4 gene (see all 146)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    troleandomycin 91.4 86 9806945 (3), 8261428 (2), 11125847 (2), 11095572 (2) (see all 50)
    1-hydroxymidazolam 88.3 19 8185679 (4), 15801939 (2), 10741627 (1), 8669558 (1) (see all 12)
    ketoconazole 87.7 171 9929500 (4), 10801218 (4), 19077665 (4), 16133532 (3) (see all 99)
    midazolam 87.2 359 7965755 (5), 8185679 (5), 7828377 (5), 16842393 (5) (see all 99)
    androstane 86.2 25 16513849 (2), 17392393 (2), 17041008 (2), 15466163 (1) (see all 22)
    6beta-hydroxycortisol 85.5 36 9753209 (2), 14605865 (2), 15298747 (2), 10463384 (2) (see all 22)
    rifampicin 85 374 17998298 (5), 16324277 (5), 20201776 (4), 11336975 (4) (see all 99)
    6beta-hydroxytestosterone 84.9 11 17581220 (1), 18094037 (1), 15037195 (1), 10497147 (1) (see all 8)
    citco 84.7 10 17585873 (1), 18347084 (1), 19202563 (1)
    furafylline 82 13 8261428 (2), 15184267 (1), 16510126 (1), 9431831 (1) (see all 7)

    Selected PharmGKB related drug/compound annotations for CYP3A4 gene (see all 85)    About this table
    Drug/compound PharmGKB Annotation
    acetaminophen
    amlodipineCA  
    anastrozole
    aripiprazole
    atorvastatin  CA  
    boceprevir
    bosutinib monohydrate
    brentuximab vedotin
    carbamazepine
    cevimeline



    Find genes that share compounds with CYP3A4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CYP3A4 gene (4 alternative transcripts): 
    NM_001202855.2  NM_017460.5  NM_001202856.1  NM_001202857.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336411 ENST00000480043 ENST00000415003 ENST00000354593(uc003urv.2 uc003urw.2 uc011kiz.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYP3A4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYP3A4 (see all 10):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-548b-5p
    SwitchGear 3'UTR luciferase reporter plasmidCYP3A4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYP3A4
    Predesigned siRNA for gene silencing in human, mouse, rat CYP3A4
    Clone
    Products:
         
    OriGene clones in human, mouse for CYP3A4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CYP3A4 (NM_001202855)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP3A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP3A4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYP3A4
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP3A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP3A4
      QuantiTect SYBR Green Assays in human, mouse, rat CYP3A4
      QuantiFast Probe-based Assays in human, mouse, rat CYP3A4
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10196) for CYP3A4 

    Selected AceView cDNA sequences (see all 189):

    AV646302 NM_017460 CB164407 AV648762 AV657487 CB164067 AV660621 AV650798 
    CB157627 AV657708 AV647783 AV646885 BG215637 BG203510 BG206682 BG182832 
    AV650720 CB157183 BG194899 BX281345 AV652769 M18907 T64744 CB156859 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CYP3A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP3A4 Expression
    About this image


    CYP3A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 6 entries
             Mature Hepatocytes Liver Lobule
             Hepatocytes
             Hepatocyte-like cells
     
     Amnion (Extraembryonic Tissues)
             Amniotic Epithelial Cells Amniotic Membrane
    CYP3A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP3A4 Protein Expression

    UniProtKB/Swiss-Prot: CP3A4_HUMAN, P08684
    Tissue specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain
    (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations
    (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine,
    bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia,
    gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the
    ovary (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP3A4: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYP3A4
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP3A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP3A4
    QuantiTect SYBR Green Assays in human, mouse, rat CYP3A4
    QuantiFast Probe-based Assays in human, mouse, rat CYP3A4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CYP3A4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CYP3A41 cytochrome P450, family 3, subfamily A, polypeptide more 63.04(n)
    61.09(a)
      416477  XM_414782.4  XP_414782.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    60(a)
    52(a)
    many ↔ many
    many ↔ many
    GL343591.1(16157-77793)
    GL343987.1(113184-127496)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688212 hypothetical protein MGC68821 75.25(n)    BC060496.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp3a656
    cyp3c1l26
    (see all 5)
    cytochrome P450, family 3, subfamily A, polypeptid...
    cytochrome P450, family 3, subfamily c, polypeptid...
    (see all 5)
    54(a)
    51(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    1(60208634-60218577) ENSDARG00000045627
    3(40942743-40950564) ENSDARG00000037873
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp6a233
    Cyp9f21
    cytochrome P4503
    Cyp9f21
    35(a)
    (best of 36)3
    47.35(n)1
    35.84(a)1
      51D13
    415201  NM_141932.31  NP_650189.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F14F7.33
    cyp-25A11
    cytochrome P4503
    cyp-25A11
    32(a)
    (best of 14)3
    46.71(n)1
    32.68(a)1
      III(13095916-13099217)3
    1832471  NM_065374.41  NP_497775.31 
            Species with no ortholog for CYP3A4

    ENSEMBL Gene Tree for CYP3A4 (if available)
    TreeFam Gene Tree for CYP3A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CYP3A4 gene
    CYP4F222  TBXAS12  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP4A222  CYP3A72  
    CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
    14 SIMAP similar genes for CYP3A4 using alignment to 5 protein entries:     CP3A4_HUMAN (see all proteins):
    CYP3A43/CYP3A4    CYP3A5    CYP3A7    CYP3A43    CYP4A11    CYP4B1
    thromboxane synthase    TBXAS1    CYP2E1    CYP4V2    CYP19A1    CYP1A1
    CYP2C9    CYP4F12

    Find genes that share paralogs with CYP3A4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CYP3A4
    PGOHUM00000232935 PGOHUM00000263172 PGOHUM00000232936


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CYP3A4 (see all 716)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114051391,2
    C,F--98731737(+) ATTCCG/AGGTCA 2 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs289885831,2
    C,F--99366709(-) CATTAT/CATTTT 2 -- int18Minor allele frequency- C:0.04NS CSA WA 310
    rs133120801,2
    --99366717(+) ATGACA/CAATAA 2 -- int10--------
    rs133120281,2
    --99366721(+) CCAATA/GATGTC 2 -- int10--------
    rs133124421,2
    --99366792(+) ATCCCC/TGGTCT 2 -- int10--------
    rs133121681,2
    --99366793(+) TCCCTG/TGTCTG 2 -- int10--------
    rs133120441,2
    --99366808(+) GGACAA/GACTCA 2 -- int10--------
    rs133120461,2
    --99366809(+) GACAAA/GCTCAG 2 -- int10--------
    rs133124921,2
    --99366827(+) CTGTTG/TTTACT 2 -- int10--------
    rs133120921,2
    --99366830(+) TTTTTA/CCTGCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for CYP3A4 (99354583 - 99381888 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP3A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv888771CNV Loss21882294
    nsv482109CNV Gain20164927

    The Human Cytochrome P450 Allele Nomenclature Database: CYP3A4 
    Human Gene Mutation Database (HGMD): CYP3A4
    Locus Specific Mutation Databases (LSDB): CYP3A4

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A4
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP3A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 124010    OMIM disorders: --

    4 diseases for CYP3A4:    
    About MalaCards
    xanthomatosis    methemoglobinemia    serotonin syndrome    beta thalassemia

    2 diseases from the University of Copenhagen DISEASES database for CYP3A4:
    Liver disease     Diarrhea

    Find genes that share disorders with CYP3A4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP3A4 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetaminophen metabolism 52.5 1 10678302 (1)
    rhabdomyolysis 46.3 5 11856903 (1), 16581331 (1), 11149552 (1), 19734738 (1)
    colon carcinoma 32.8 18 12419308 (2), 14615069 (2), 12625868 (2), 12738030 (1) (see all 13)
    immunodeficiency 30.4 15 12189360 (1), 15657782 (1), 16433896 (1), 14985144 (1) (see all 11)
    torsades de pointes 23.6 5 15762770 (1), 9545159 (1), 12949438 (1)
    liver diseases 21.5 4 7741759 (1), 9131486 (1), 9927612 (1), 19620337 (1)
    colon adenocarcinoma 18.8 4 18332086 (1), 9822896 (1), 10871337 (1), 11602520 (1)
    liver dysfunction 18.7 2 12867215 (1), 18183036 (1)
    neutropenia 17 4 17992531 (2), 19696793 (1), 20068078 (1)
    cholestasis 14.9 5 15454728 (1), 16455805 (1), 15726657 (1), 15708356 (1)

    Genetic Association Database (GAD): CYP3A4
    Human Genome Epidemiology (HuGE) Navigator: CYP3A4 (383 documents)

    Export disorders for CYP3A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CYP3A4 gene, integrated from 10 sources (see all 2287):
    (articles sorted by number of sources associating them with CYP3A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. (PubMed id 15634941)1, 4, 7 Lee S.J....Goldstein J.A. (J. Pharmacol. Exp. Ther. 2005)
    2. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. (PubMed id 11714865)1, 2, 4 Dai D.... Goldstein J.A. (J. Pharmacol. Exp. Ther. 2001)
    3. Novel mutations of CYP3A4 in Chinese. (PubMed id 11181494)1, 2, 4 Hsieh K.-P.... Huang J.-D. (Drug Metab. Dispos. 2001)
    4. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PubMed id 19934400)1, 4, 9 Lamba V....Schuetz E.G. (J. Pharmacol. Exp. Ther. 2010)
    5. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. (PubMed id 15454728)1, 7, 9 Gnerre C....Meyer U.A. (Pharmacogenetics 2004)
    6. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. (PubMed id 18332045)1, 7, 9 Cooper B.W....Wallace A.D. (Toxicol. Sci. 2008)
    7. Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients. (PubMed id 17992531)1, 4, 9 Sai K....Sawada J. (Cancer Chemother. Pharmacol. 2008)
    8. A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan. (PubMed id 20068078)1, 4, 9 van der Bol J.M....de Jong F.A. (Clin. Cancer Res. 2010)
    9. Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients. (PubMed id 17605821)1, 4, 9 Gervasini G....AgA_ndez J.A. (BMC Cancer 2007)
    10. Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population. (PubMed id 16981844)1, 4, 9 Du J....He L. (Pharmacogenomics 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1576 HGNC: 2637 AceView: CYP3A4 Ensembl:ENSG00000160868 euGenes: HUgn1576
    ECgene: CYP3A4 Kegg: 1576 H-InvDB: CYP3A4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CYP3A4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP3A4 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp3a4.htm
    Wikipedia http://en.wikipedia.org/wiki/CYP3A4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CYP3A4 gene:
    Search GeneIP for patents involving CYP3A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP3A4
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CYP3A4   OriGene RNAi products in human, mouse, rat for CYP3A4  
     OriGene qPCR primer pairs and template standards for CYP3A4   OriGene Protein Over-expression Lysate for CYP3A4  
     OriGene MassSpec for CYP3A4   OriGene clones in human, mouse for CYP3A4  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYP3A4   OriGene Purified Protein for CYP3A4  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYP3A4   OriGene Custom Protein Services for CYP3A4  

     
     
     Block miRNA regulation of human, mouse, rat CYP3A4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CYP3A4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A4 Predesigned siRNA for gene silencing in human, mouse, rat CYP3A4
     QuantiFast Probe-based Assays in human, mouse, rat CYP3A4 QuantiTect SYBR Green Assays in human, mouse, rat CYP3A4
     PCR Arrays including human, mouse, rat CYP3A4 Search Chromatin IP Primers for CYP3A4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP3A4  GeneGlobe Interaction Network for CYP3A4
     Regulatory tfbs in CYP3A4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CYP3A4 GenScript cDNA clones with any tag delivered in your preferred vector for CYP3A4
     GenScript Custom Assay Services for CYP3A4 GenScript Custom overexpressing Cell Line Services for CYP3A4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CYP3A4 

     Tocris compounds for CYP3A4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CYP3A4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CYP3A4 antibodies
     CYP3A4 proteins
     CYP3A4 lysates
     Antibodies for CYP3A4
     See all of Abcam's Antibodies, Kits and Proteins for CYP3A4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CYP3A4
     Antibodies for CYP3A4
     ELISAs for CYP3A4
     CLIAs for CYP3A4



     Browse ESI BIO Cell Lines and PureStem Progenitors for CYP3A4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP3A4
     SwitchGear 3'UTR luciferase reporter plasmids for CYP3A4
     SwitchGear Promoter luciferase reporter plasmids for CYP3A4
     ThermoFisher Antibody for CYP3A4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP3A4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP3A4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP3A4
     LSBio Antibodies in human, mouse, rat for CYP3A4
     Browse compounds at ApexBio
     Search Addgene for plasmids for CYP3A4
      Search eBioscience for proteins for CYP3A4
      Search eBioscience for elisas for CYP3A4
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for CYP3A4 (83 products)
     antibodies-online kits for CYP3A4 (17 products)
     antibodies-online peptides for CYP3A4
     antibodies-online proteins for CYP3A4 (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYP3A4 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4