CYP3A Gene
uncategorized GIFtS : 19 GCID: GC07 M099245
cytochrome P450, family 3, subfamily A cytochrome P450, subfamily IIIA (niphedipine oxidase) )CYP3 )
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Aliasesfor CYP3A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cytochrome P450, Family 3, Subfamily A 1 2 CYP31 2 Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase)1
Export aliases for CYP3A gene to outside databases Previous GC identifers: GC07U990017 GC07M099084
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Summariesfor CYP3A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CYP3A : The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes, CYP3A43, CYP3A4, CYP3A7 and CYP3A5. The region also contains two pseudogenes, CYP3A5P1 and CYP3A5P2, as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. (provided by RefSeq, Jul 2008) Gene Wiki entry for CYP3A
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Genomic Viewsfor CYP3A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for CYP3A Other transcription factors Search SABiosciences Chromatin IP Primers for CYP3A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q21.3-q22.1 HGNC cytogenetic band: 7q21.3-q22.1 CYP3A Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M099245: view genomic region
(about GC identifiers )
Start: 99,245,813 bp from pter End:
99,464,173 bp from pter
Size: 218,361 bases Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 98,605,608-98,823,992
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Proteinsfor CYP3A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB: --
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Protein
Domains /for CYP3A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Functionfor CYP3A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for CYP3A cytochrome P450,family III (niphedipine oxidase),5 genes
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Pathways & Interactionsfor CYP3A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Estrogen metabolism
1 CYP3A Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP3A
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Drugs & Compoundsfor CYP3A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for CYP3A 8 Novoseek chemical compound relationships for CYP3A gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
pregnenolone 16alpha-carbonitrile
78.1
3
15319343 (2)
6beta-hydroxycortisol
74.4
3
10805065 (3)
ketoconazole
49.1
1
11695850 (1)
rifampicin
46
4
15319343 (3)
dexamethasone
42
2
15319343 (1)
testosterone
35.7
1
17914095 (1)
cyclosporin a
18.6
1
8018545 (1)
steroid
11.2
1
9717460 (1)
8 PharmGKB related drug/compound annotations for CYP3A gene About this table
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Transcriptsfor CYP3A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section GeneLoc Exon Structure
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Expression for CYP3A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- CYP3A expression in embryonic tissues and stem cells About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category Hepatocytes (Primary Cell)Liver Immature hepatocyte-like cells (Hepatocyte-like cell... )Expression: Experimental details:
In-situ hybridization
SABiosciences Custom PCR Arrays for CYP3A Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CYP3A Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3A Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3A
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Orthologsfor CYP3A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
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Paralogsfor CYP3A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor CYP3A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor CYP3A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing 9 : About MalaCards cholesterol fatty liver disease viral hepatitis liver disease duodenitis colorectal cancer prostate cancer hepatitis prostatitis 1 Novoseek disease relationship for CYP3A gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cancer
0
1
16314882 (1)
Genetic Association Database (GAD): CYP3A Human Genome Epidemiology (HuGE) Navigator: CYP3A (484 documents) Export disorders for CYP3A gene to outside databases
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Publicationsfor CYP3A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CYP3A gene, integrated from 9 sources (see all 103 ):(articles sorted by number of sources associating them with CYP3A) Utopia : connect your pdf to the dynamic
Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations. (PubMed id 16344723) 1 , 4(2006) Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles. (PubMed id 16171783) 1 , 4(2005) Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes. (PubMed id 15752376) 1 , 4(2005) Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation. (PubMed id 16146556) 1 , 4(2005) CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation. (PubMed id 15226679) 1 , 4(2004) The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation. (PubMed id 15147425) 1 , 4(2004) CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy. (PubMed id 15179407) 1 , 4(2004) CYP3A variation and the evolution of salt-sensitivity variants. (PubMed id 15492926) 1 , 4(2004) Genotype relationships in the CYP3A locus in Caucasians. (PubMed id 15050738) 1 , 4(2004) CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia. (PubMed id 12846892) 1 , 4(2003)
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External Searches for CYP3A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CYP3A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CYP3A gene
(According to HUGE )
About This Section --
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Specialized Databases showing CYP3A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for CYP3A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CYP3A gene: CYP3A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CYP3A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP3A Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP3A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP3A Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP3A Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP3A Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP3A
Search Tocris compounds for CYP3A
Search ThermoFisher Antibodies for CYP3A
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CYP3A
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Aliases for CYP3A
Databases for CYP3A
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Function for CYP3A
Genomic Views for CYP3A
Intellectual Property for CYP3A
Orthologs for CYP3A
Paralogs for CYP3A
Pathways / Interactions for CYP3A
Products for CYP3A
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Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Microarrays
In-situ hybridization
