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Aliases for CYP3A Gene

Aliases for CYP3A Gene

  • Cytochrome P450, Family 3, Subfamily A 2 3
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase) 2 3
  • CYP3 3

External Ids for CYP3A Gene

Previous HGNC Symbols for CYP3A Gene

  • CYP3

Previous GeneCards Identifiers for CYP3A Gene

  • GC07M099084
  • GC07M099245

Summaries for CYP3A Gene

Entrez Gene Summary for CYP3A Gene

  • The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes, CYP3A43, CYP3A4, CYP3A7 and CYP3A5. The region also contains two pseudogenes, CYP3A5P1 and CYP3A5P2, as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP3A Gene

CYP3A (Cytochrome P450, Family 3, Subfamily A) is a Genetic Locus. Among its related pathways are Estrogen metabolism.

Gene Wiki entry for CYP3A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A Gene

Genomics for CYP3A Gene

Genomic Location for CYP3A Gene

Chromosome:
7
Orientation:
Unknown strand

Genomic View for CYP3A Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for CYP3A Gene

Proteins for CYP3A Gene

Post-translational modifications for CYP3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for CYP3A Gene

Domains & Families for CYP3A Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CYP3A Gene

Function for CYP3A Gene

Molecular function for CYP3A Gene

GENATLAS Biochemistry:
cytochrome P450,family III (niphedipine oxidase),5 genes

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A Gene

Localization for CYP3A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CYP3A Gene

Pathways & Interactions for CYP3A Gene

SuperPathways for CYP3A Gene

Superpath Contained pathways
1 Estrogen metabolism
genes like me logo Genes that share pathways with CYP3A: view

Pathways by source for CYP3A Gene

1 PharmGKB pathway for CYP3A Gene

Interacting Proteins for CYP3A Gene

Gene Ontology (GO) - Biological Process for CYP3A Gene

None

No data available for SIGNOR curated interactions for CYP3A Gene

Drugs & Compounds for CYP3A Gene

(44) Drugs for CYP3A Gene - From: ClinicalTrials, PharmGKB, ApexBio, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1792
Clopidogrel Approved Nutra P2Y12 receptor antagonist 674
Ketoconazole Approved, Investigational Pharma Pore Blocker Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 171
Rifampin Approved Pharma Inhibition, Inhibitor 290
bosutinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors, Dual Src-Abl inhibitor; antiproliferative 0

(3) Additional Compounds for CYP3A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6beta-Hydroxycortisol
Pregnenolone 16alpha-carbonitrile
Steroid
genes like me logo Genes that share compounds with CYP3A: view

Transcripts for CYP3A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A Gene

No ASD Table

Relevant External Links for CYP3A Gene

ECgene alternative splicing isoforms for
CYP3A

No data available for mRNA/cDNA for CYP3A Gene

Expression for CYP3A Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYP3A Gene

Orthologs for CYP3A Gene

No data available for Orthologs and Evolution for CYP3A Gene

Paralogs for CYP3A Gene

No data available for Paralogs for CYP3A Gene

Variants for CYP3A Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for CYP3A Gene

Disorders for CYP3A Gene

Relevant External Links for CYP3A

Genetic Association Database (GAD)
CYP3A
Human Genome Epidemiology (HuGE) Navigator
CYP3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A
genes like me logo Genes that share disorders with CYP3A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A Gene

Publications for CYP3A Gene

  1. Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort. (PMID: 19205682) Zhao Y. … Ji H. (Eur. J. Clin. Pharmacol. 2009) 23 67
  2. Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. (PMID: 19651758) Fisher C.D. … Cherrington N.J. (Drug Metab. Dispos. 2009) 23 67
  3. Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies. (PMID: 18059400) Sharma R. … Robertson G. (Br. J. Cancer 2008) 23 67
  4. CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7. (PMID: 18216722) Qiu H. … Wojnowski L. (Pharmacogenet. Genomics 2008) 23 67
  5. Phenotyping of cytochrome P450 3A enzyme in Gujarat population. (PMID: 19356063) Jani A.J. … Mehta A.A. (Drug Metab Lett 2008) 23 67

Products for CYP3A Gene

Sources for CYP3A Gene

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