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Aliases for CYP3A Gene

Aliases for CYP3A Gene

  • Cytochrome P450, Family 3, Subfamily A 2 3
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase) 2 3
  • CYP3A43 6
  • CYP3 3

External Ids for CYP3A Gene

Previous HGNC Symbols for CYP3A Gene

  • CYP3

Previous GeneCards Identifiers for CYP3A Gene

  • GC07M099084
  • GC07M099245

Summaries for CYP3A Gene

Entrez Gene Summary for CYP3A Gene

  • The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes, CYP3A43, CYP3A4, CYP3A7 and CYP3A5. The region also contains two pseudogenes, CYP3A5P1 and CYP3A5P2, as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP3A Gene

CYP3A (Cytochrome P450, Family 3, Subfamily A) is a Genetic Locus. Among its related pathways are Metabolism and Chemical carcinogenesis.

Gene Wiki entry for CYP3A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A Gene

Genomics for CYP3A Gene

Genomic Location for CYP3A Gene

Unknown strand

Genomic View for CYP3A Gene

Cytogenetic band:

No data available for Regulatory Elements and RefSeq DNA sequence for CYP3A Gene

Proteins for CYP3A Gene

Post-translational modifications for CYP3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for CYP3A Gene

Domains for CYP3A Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CYP3A Gene

Function for CYP3A Gene

Molecular function for CYP3A Gene

GENATLAS Biochemistry:
cytochrome P450,family III (niphedipine oxidase),5 genes

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A Gene

Localization for CYP3A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CYP3A Gene

Pathways for CYP3A Gene

genes like me logo Genes that share pathways with CYP3A: view

Pathways by source for CYP3A Gene

Interacting Proteins for CYP3A Gene

Gene Ontology (GO) - Biological Process for CYP3A Gene


Drugs for CYP3A Gene

(2) ApexBio Compounds for CYP3A Gene

Compound Action Cas Number
Clarithromycin [81103-11-9]
Cobicistat (GS-9350) Selective CYP3A inhibitor [1004316-88-4]

(8) Novoseek inferred chemical compound relationships for CYP3A Gene

Compound -log(P) Hits PubMed IDs
pregnenolone 16alpha-carbonitrile 78.1 2
6beta-hydroxycortisol 74.4 3
ketoconazole 49.1 1
rifampicin 46 3
dexamethasone 42 1

(13) PharmGKB related drug/compound annotations for CYP3A Gene

Drug/compound Annotation
bosutinib DrugLabel,Clinical Annotation
clopidogrel DrugLabel,Clinical Annotation
crizotinib DrugLabel,Clinical Annotation
docetaxel DrugLabel,Clinical Annotation
efavirenz DrugLabel,Clinical Annotation
erythromycin DrugLabel,Clinical Annotation
fluoxetine DrugLabel,Clinical Annotation
nelfinavir DrugLabel,Clinical Annotation
nifedipine DrugLabel,Clinical Annotation
olanzapine DrugLabel,Clinical Annotation
paclitaxel DrugLabel,Clinical Annotation
ponatinib DrugLabel,Clinical Annotation
telaprevir DrugLabel,Clinical Annotation
genes like me logo Genes that share compounds with CYP3A: view

Transcripts for CYP3A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A Gene

No ASD Table

Relevant External Links for CYP3A Gene

ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for CYP3A Gene

Expression for CYP3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with CYP3A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CYP3A Gene

Orthologs for CYP3A Gene

No data available for Orthologs and Evolution for CYP3A Gene

Paralogs for CYP3A Gene

No data available for Paralogs for CYP3A Gene

Variants for CYP3A Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CYP3A Gene

Disorders for CYP3A Gene

(1) Novoseek inferred disease relationships for CYP3A Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for CYP3A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYP3A: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CYP3A Gene

Publications for CYP3A Gene

  1. Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy. (PMID: 12237780) MartA-nez C. … AgA_ndez J.A. (Br. J. Cancer 2002) 3 23
  2. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. (PMID: 14977871) Sunman J.A. … Kashuba A.D. (Drug Metab. Dispos. 2004) 3 23
  3. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4- cineole, a monoterpene cyclic ether, by rat and human liver microsomes. (PMID: 11695850) Miyazawa M. … Shimada T. (Xenobiotica 2001) 3 23
  4. CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia. (PMID: 12846892) Aplenc R. … Rebbeck T. (Br. J. Haematol. 2003) 3 48
  5. Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients. (PMID: 14578760) Thervet E. … Daly A.K. (Transplantation 2003) 3 48

Products for CYP3A Gene

Sources for CYP3A Gene

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