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CYP3A Locus

genetic locus   GIFtS: 20
GCID: GC07U990017

Cytochrome P450, Family 3, Subfamily A

(Previous names: cytochrome P450, subfamily IIIA (niphedipine oxidase))
(Previous symbol: CYP3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 3, Subfamily A1 2
CYP31 2
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase)1
CYP3A435

External Ids:    HGNC: 26351   Entrez Gene: 15742   OMIM: 6065345   

Export aliases for CYP3A gene to outside databases

Previous GC identifers: GC07M099084 GC07M099245


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP3A Gene:
The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes.
These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of
cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes, CYP3A43, CYP3A4, CYP3A7 and
CYP3A5. The region also contains two pseudogenes, CYP3A5P1 and CYP3A5P2, as well as several extra exons which may
or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was
thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CYP3A Gene:
CYP3A (cytochrome P450, family 3, subfamily A) is a genetic locus.

Gene Wiki entry for CYP3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CYP3A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP3A promoter sequence
   Search Chromatin IP Primers for CYP3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP3A


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q21.3-q22.1   HGNC cytogenetic band: 7q21.3-q22.1

GeneLoc information about chromosome 7        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CYP: Cytochrome P450s

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for CYP3A:
cytochrome P450,family III (niphedipine oxidase),5 genes

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CYP3A

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CYP3A About    
See pathways by source

SuperPathContained pathways About
1Estrogen metabolism
Estrogen Metabolism Pathway0.43


1 PharmGKB Pathway for CYP3A
    Estrogen Metabolism Pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYP3A
Interactions:

    GeneGlobe Interaction Network for CYP3A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CYP3A

8 Novoseek inferred chemical compound relationships for CYP3A gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pregnenolone 16alpha-carbonitrile 78.1 3 15319343 (2)
6beta-hydroxycortisol 74.4 3 10805065 (3)
ketoconazole 49.1 1 11695850 (1)
rifampicin 46 4 15319343 (3)
dexamethasone 42 2 15319343 (1)
testosterone 35.7 1 17914095 (1)
cyclosporin a 18.6 1 8018545 (1)
steroid 11.2 1 9717460 (1)

Selected PharmGKB related drug/compound annotations for CYP3A gene (see all 13)    About this table
Drug/compound PharmGKB Annotation
bosutinib monohydrate
clopidogrel
crizotinib
docetaxelCA  
efavirenzCA  
erythromycinCA  
fluoxetine
nelfinavir
nifedipineCA  
olanzapine



Find genes that share compounds with CYP3A           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


CYP3A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Liver (Hepatobiliary System)    fully expand to see all 2 entries
         Hepatocytes
         Immature hepatocyte-like cells
CYP3A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CYP3A
DNA2.0 Custom Variant and Variant Library Synthesis for CYP3A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606534    OMIM disorders: --


Find genes that share disorders with CYP3A           About GenesLikeMe

1 Novoseek inferred disease relationship for CYP3A gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cancer 0 1 16314882 (1)

Genetic Association Database (GAD): CYP3A
Human Genome Epidemiology (HuGE) Navigator: CYP3A (484 documents)

Export disorders for CYP3A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CYP3A gene, integrated from 10 sources (see all 112):
(articles sorted by number of sources associating them with CYP3A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
  2. Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. (PubMed id 18183034)1, 4 Wyen C....Jetter A. (Clin. Pharmacol. Ther. 2008)
  3. Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PubMed id 18056193)1, 4 Tham L.S....Goh B.C. (Clin. Cancer Res. 2007)
  4. Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. (PubMed id 16912957)1, 4 Haas D.W....Kim R.B. (Clin. Infect. Dis. 2006)
  5. Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel. (PubMed id 17020985)1, 4 Bosch T.M....Schellens J.H. (Clin. Cancer Res. 2006)
  6. Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. (PubMed id 16754899)1, 4 Suh J.W....Kim H.S. (CMAJ 2006)
  7. Influence of different allelic variants of the CYP3A and ABCB1 genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant recipients. (PubMed id 16753004)1, 4 Cheung C.Y....Bekers O. (Pharmacogenomics 2006)
  8. Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles. (PubMed id 16171783)1, 4 RodrA-guez-Antona C....Ingelman-Sundberg M. (Biochem. Biophys. Res. Commun. 2005)
  9. Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes. (PubMed id 15752376)1, 4 Saito M....Tateishi T. (Br J Clin Pharmacol 2005)
  10. Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation. (PubMed id 16146556)1, 4 Zhang X....Li L.S. (Clin Transplant 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1574 HGNC: 2635 euGenes: HUgn1574 ECgene: CYP3A H-InvDB: CYP3A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CYP3A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CYP3A gene:
Search GeneIP for patents involving CYP3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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