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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP39A1 Gene

protein-coding   GIFtS: 56
GCID: GC06M046564

Cytochrome P450, Family 39, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 39, Subfamily A, Polypeptide 11 2     Cytochrome P450 39A13
Cytochrome P450, Subfamily XXXIX (Oxysterol 7 Alpha-Hydroxylase),
Polypeptide 11 2
     hCYP39A13
24-Hydroxycholesterol 7-Alpha-Hydroxylase2     Oxysterol 7-Alpha-Hydroxylase3
EC 1.14.13.993     

External Ids:    HGNC: 174491   Entrez Gene: 513022   Ensembl: ENSG000001462337   OMIM: 6059945   UniProtKB: Q9NYL53   

Export aliases for CYP39A1 gene to outside databases

Previous GC identifers: GC06M046519 GC06M046625 GC06M046240


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP39A1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids.
Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol.
Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for CYP39A1 Gene: 
CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP39A1 include cytochrome p450, and open-angle glaucoma, and among its related super-pathways are Synthesis of bile acids and bile salts and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is PTGIS.

UniProtKB/Swiss-Prot: CP39A_HUMAN, Q9NYL5
Function: Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a
7-alpha-hydroxylated product

Gene Wiki entry for CYP39A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP39A1 gene promoter:
         Sox5   HOXA3   STAT5A   CUTL1   MIF-1   PPAR-alpha   FAC1   Cart-1   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP39A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP39A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP39A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1-p11.2   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.1-p11.2

CYP39A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP39A1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M046564:  view genomic region     (about GC identifiers)

Start:
46,517,445 bp from pter      End:
46,620,523 bp from pter
Size:
103,079 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP39A_HUMAN, Q9NYL5 (See protein sequence)
Recommended Name: 24-hydroxycholesterol 7-alpha-hydroxylase  
Size: 469 amino acids; 54116 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: Q5VTT0 Q96FW5

Explore the universe of human proteins at neXtProt for CYP39A1: NX_Q9NYL5

Explore proteomics data for CYP39A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYL5

  • CYP39A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP39A1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265667.1  NP_001265668.1  NP_057677.2  

    ENSEMBL proteins: 
     ENSP00000275016  
    Reactome Protein details: Q9NYL5
    Human Recombinant Protein Products for CYP39A1: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle TAS10748047

    CYP39A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP39A1  
    CYP39, CYP46 and CYP51 families

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR002403 Cyt_P450_E_grp-IV
     IPR024204 Cyt_P450_CYP7A1-type

    Graphical View of Domain Structure for InterPro Entry Q9NYL5

    ProtoNet protein and cluster: Q9NYL5

    1 Blocks protein domain: IPB002403 E-class P450 group IV signature

    UniProtKB/Swiss-Prot: CP39A_HUMAN, Q9NYL5
    Similarity: Belongs to the cytochrome P450 family


    CYP39A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP39A_HUMAN, Q9NYL5
    Function: Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a
    7-alpha-hydroxylated product
    Catalytic activity: (24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) =
    (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O

         Enzyme Number (IUBMB): EC 1.14.13.991

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0008387steroid 7-alpha-hydroxylase activity IEA--
    GO:0008396oxysterol 7-alpha-hydroxylase activity IDA10748047
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
         
    CYP39A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cyp39a1 (no phenotypes)

    CYP39A1 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP39A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts0.87
    Primary bile acid biosynthesis0.74
    Bile acid and bile salt metabolism0.74
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol0.61
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    3Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    4Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    5Endogenous sterols
    Endogenous sterols

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP39A1
        cytochrome P450
    metapathway biotransformation


    5/9        Reactome Pathways for CYP39A1 (see all 9)
        Cytochrome P450 - arranged by substrate type
    Bile acid and bile salt metabolism
    Metabolism
    Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol


    1         Kegg Pathway  (Kegg details for CYP39A1):
        Primary bile acid biosynthesis


    CYP39A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP39A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for CYP39A1 (ENSP000002750164) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP46A1ENSP000002618354STRING: ENSP00000261835
    HSD3B7ENSP000002976794STRING: ENSP00000297679
    GLULENSP000003079004STRING: ENSP00000307900
    ORM2ENSP000003949364STRING: ENSP00000394936
    SERINC1ENSP000003429624STRING: ENSP00000342962
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006699bile acid biosynthetic process TAS--
    GO:0006707cholesterol catabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007586digestion TAS10748047
    GO:0008206bile acid metabolic process TAS--

    CYP39A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYP39A1 (CP39A)

    5 HMDB Compounds for CYP39A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    (24R)-Cholest-5-ene-3-beta,24-diolCholest-5-ene-3,24-diol (see all 6)----
    (24R)-Cholest-5-ene-3-beta,7-alpha,24-triol5a-cholesta-7,24-dien-3-b-ol (see all 4)----
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    Search CenterWatch for drugs/clinical trials and news about CYP39A1 / CP39A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP39A1 gene (3 alternative transcripts): 
    NM_001278738.1  NM_001278739.1  NM_016593.4  

    Unigene Cluster for CYP39A1:

    Cytochrome P450, family 39, subfamily A, polypeptide 1
    Hs.387367  [show with all ESTs]
    Unigene Representative Sequence: NM_016593
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275016(uc003oyf.1 uc011dwa.1 uc010jzd.1) ENST00000489657
    ENST00000476076 ENST00000480804
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    Additional mRNA sequence: 

    AK292263.1 AK301604.1 AK307986.1 BC010358.1 

    6 DOTS entries:

    DT.110931  DT.91894346  DT.75154156  DT.95101542  DT.121359465  DT.95101543 

    24/81 AceView cDNA sequences (see all 81):

    BG679299 AA811280 AI370326 AF237982 AI628701 BF063625 CA391326 AI084834 
    NM_016593 AI051214 BG697296 CB128756 AV649791 CD628064 BM906039 BX284107 
    CD628052 AI560102 BG211724 BG192090 BP377615 AA890449 BU678389 AA682428 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP39A1 expression in normal human tissues (normalized intensities)      CYP39A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAACTGTA
    CYP39A1 Expression
    About this image


    CYP39A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland   
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             sensory organ/ear/inner ear   

    See CYP39A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP39A1

    SOURCE GeneReport for Unigene cluster: Hs.387367

    UniProtKB/Swiss-Prot: CP39A_HUMAN, Q9NYL5
    Tissue specificity: Liver specific

        SABiosciences Expression via Pathway-Focused PCR Array including CYP39A1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYP39A1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp39a11 , 5 cytochrome P450, family 39, subfamily a, polypeptide more1, 5 80.69(n)1
    75.75(a)1
      17 (19.75 cM)5
    560501  NM_018887.31  NP_061375.11 
     436674255 
    chicken
    (Gallus gallus)
    Aves CYP39A11 cytochrome P450, family 39, subfamily A, polypeptide more 63.69(n)
    58.12(a)
      422058  XM_420063.3  XP_420063.3 
    lizard
    (Anolis carolinensis)
    Reptilia CYP39A16
    Uncharacterized protein
    52(a)
    1 ↔ 1
    1(138598295-138632236)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp39a11 cytochrome P450, family 39, subfamily A, polypeptide more 57.33(n)
    49.57(a)
      564475  NM_001030189.1  NP_001025360.1 


    ENSEMBL Gene Tree for CYP39A1 (if available)
    TreeFam Gene Tree for CYP39A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP39A1 gene
    PTGIS2  CYP7A12  CYP7B12  CYP8B12  
    1 SIMAP similar gene for CYP39A1 using alignment to 1 protein entry:     CP39A_HUMAN:
    CYP7B1

    CYP39A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2129 SNPs in CYP39A1 are shown (see all 2129)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928009351,2
    --46427613(+) ATTAGA/TCTGGA 1 -- ds50010--------
    rs1399372621,2
    --46427696(+) TAAGCA/TATCAT 1 -- ds50010--------
    rs1453641471,2
    C--46427718(+) TGGGAC/TAATTC 1 -- ds50010--------
    rs8065091,2
    C,F,H--46427806(-) AAGTGC/TTGCTT 1 -- ds500119Minor allele frequency- T:0.09NS EA NA WA 2198
    rs1510295171,2
    C--46428029(+) TATAAC/TTGCAA 1 -- ds50010--------
    rs1404086831,2
    --46428097(+) TCAACA/GTACAT 1 -- ut310--------
    rs1164381371,2
    C,F--46428109(+) TATTGA/GATATA 1 -- ut311Minor allele frequency- G:0.05WA 118
    rs93814611,2
    C,F,A,H--46428385(+) TGCTGC/TCTTCA 1 -- ut3121Minor allele frequency- T:0.20NS EA NA CSA WA 2453
    rs1115978961,2
    C,F--46428390(+) CCTTCG/ACAGTG 1 -- ut313Minor allele frequency- A:0.50WA CSA 6
    rs758171501,2
    C--46428423(+) ATTCAA/TATGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CYP39A1 (46517445 - 46620523 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CYP39A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662881CNV Deletion23128226
    nsv348640CNV Loss16902084
    nsv885868CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605994    OMIM disorders: --

    8 diseases for CYP39A1:    About MalaCards
    cytochrome p450    open-angle glaucoma    primary open angle glaucoma    glaucoma
    esophageal adenocarcinoma    tuberculosis    esophagitis    adenocarcinoma


    CYP39A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYP39A1
    Human Genome Epidemiology (HuGE) Navigator: CYP39A1 (2 documents)

    Export disorders for CYP39A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP39A1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CYP39A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. (PubMed id 10748047)1, 2, 3 Li-Hawkins J.... Russell D.W. (2000)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    6. Primary open-angle glaucoma: association with cholest erol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholester ol levels. (PubMed id 19553612)1 Fourgeux C....Bretillon L. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51302 HGNC: 17449 AceView: CYP39A1 Ensembl:ENSG00000146233 euGenes: HUgn51302
    ECgene: CYP39A1 Kegg: 51302 H-InvDB: CYP39A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP39A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP39A1 gene:
    Search GeneIP for patents involving CYP39A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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