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CYP2W1 Gene

protein-coding   GIFtS: 49

GC07P000989
cytochrome P450, family 2, subfamily W, polypeptide 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for CYP2W1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
cytochrome P450, family 2, subfamily W, polypeptide 11 2
MGC342871 2
CYPIIW12 3
FLJ203591
cytochrome P450 2W12
EC 1.14.14.-3

External Ids:    HGNC: 202431   Entrez Gene: 549052   Ensembl: ENSG000000730677   UniProtKB: Q8TAV33   

Search outside databases for aliases for CYP2W1 gene

Previous GC identifers: GC00U916974 GC07P000796

Summaries
for CYP2W1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  User Feedback		 Entrez Gene summary for CYP2W1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. (provided by RefSeq)

Genomic Views
for CYP2W1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CYP2W1 gene upstream (promoter) region "":
c-Jun   c-Fos   AP-1   Sox9   RREB-1   E47   AP-2rep   AREB6   c-Myc   Max   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP2W1:  ""
MePH28605-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

CYP2W1 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P000989:  view genomic region     (about GC identifiers)

Start:
 1,022,835 bp from pter
End:
 1,029,276 bp from pter
Size:
 6,442 bases
Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 1,077,465-1,083,884     
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NT_079592.2  

Proteins
for CYP2W1 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: CP2W1_HUMAN, Q8TAV3 (See protein sequence)
Recommended Name: Cytochrome P450 2W1  
Size: 490 amino acids; 53844 Da
Cofactor: Heme group (By similarity)
Subcellular location: Membrane; Peripheral membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass
membrane protein (Potential)

REFSEQ proteins: NP_060251.2  

ENSEMBL proteins: 
ENSP00000392581 ENSP00000310149 ENSP00000344178 


Human Recombinant Proteins 
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Novus Biologicals Lysate for CYP2W1
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5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane EXP16677611
GO:0016020 membrane IEA--
GO:0016021 integral to membrane ----
GO:0019898 extrinsic to membrane ----
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Antibodies for CYP2W1: 
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Assays for CYP2W1: 
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""Enzo Life Sciences assays for CYP2W1

Protein Domains/
Families
for CYP2W1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001128 Cyt_P450
 IPR017973 Cyt_P450_C
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q8TAV3

ProtoNet protein and cluster: Q8TAV3

1 Blocks protein family: IPB002401 E-class P450 group I signature

UniProtKB/Swiss-Prot: CP2W1_HUMAN, Q8TAV3
Similarity: Belongs to the cytochrome P450 family

Gene Function
for CYP2W1 gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (CYP2W1)
"" Origene 29mer shRNA kits in GFP-retroviral vector: CYP2W1
Origene shRNA RFP: CYP2W1
Origene basic RS shRNA: CYP2W1

""Applied Biosystems Silencer® siRNAs for CYP2W1
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Sigma-Aldrich shRNA for CYP2W1
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Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2W1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2W1
Origene untagged cDNA clones in CMV expression vector (see all 2): CYP2W1
""Browse Sino Biological Human cDNA Clones  ""

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004497 monooxygenase activity EXP16677611
GO:0005506 iron ion binding ----
GO:0009055 electron carrier activity IEA--
GO:0020037 heme binding IEA--
GO:0046872 metal ion binding IEA--
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Pathways & Interactions
for CYP2W1 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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  User Feedback		"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2W1

1 Interacting protein for CYP2W1 (ENSP000003101493) via UniProtKB, MINT, and/or STRING ""
InteractantInteraction Details
GeneCardExternal ID(s)
AOX1ENSP000003638323STRING: ENSP00000363832
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1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0055114 oxidation reduction IEA--
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Drugs & Compounds
for CYP2W1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" Enzo Life Sciences drugs & compounds for CYP2W1
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for CYP2W1
6 ""Novoseek chemical compound relationships for CYP2W1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
benzphetamine 5.58 2 19596602 (1), 16551781 (1)
indole 3.87 2 19596602 (1), 16677611 (1)
arachidonic acid 3.24 3 16677611 (1), 16551781 (1), 16426568 (1)
chlorzoxazone 2.49 1 16677611 (1)
3-methylindole 2.44 1 16677611 (1)
5-aza-2'deoxycytidine 2.03 1 16426568 (1)
About this table


Transcripts
for CYP2W1 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (CYP2W1)
""Applied Biosystems Silencer® siRNAs:  NM_017781  
"" Origene 29mer shRNA kits in GFP-retroviral vector: CYP2W1
Origene shRNA RFP: CYP2W1
Origene basic RS shRNA: CYP2W1

""Sigma-Aldrich siRNA Panels and siRNA for CYP2W1
Sigma-Aldrich shRNA for CYP2W1
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate CYP2W1: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_017781  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2W1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2W1
Origene untagged cDNA clones in CMV expression vector (see all 2): CYP2W1
Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2W1
""SABiosciences RT2 qPCR Primer Assay for CYP2W1: PPH15517A ""

REFSEQ mRNAs for CYP2W1 gene: 

NM_017781.2  

Additional cDNA sequence: 

AK000366.1 BC025761.1 CR599457.1 

6 DOTS entries:

DT.100751090  DT.97839280  DT.100751088  DT.97839281  DT.97839282  DT.92324190 

24/35 AceView cDNA sequences (see all 35 ):

BM766605 BC025761 BM767876 CR599457 BM767532 BU150425 CD628608 AK000366 
NM_017781 CD628619 BI772553 AL520637 BX439125 CD628616 AL561898 BM738552 
CD628610 CD628614 AU119534 BX281067 BM743596 CD628617 BP351592 BM744050 

"" highest scoring ESTs for CYP2W1:

AI925040 AK000366 AL561898 BC025761 BQ651786 AL520637 AU145848 BI772553 BU150425 BX412172 

Unigene Cluster for CYP2W1:

Cytochrome P450, family 2, subfamily W, polypeptide 1
Hs.272795  [show with all ESTs]
Unigene Representative Sequence: AK000366


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2W1

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1:                          -                                   -                                 
SP2:                          -                                                                     
SP3:                                                              -                                 
SP4:                                            -     -           -                                 
SP5:                                                                                                

About this scheme

ECgene alternative splicing isoforms for CYP2W1

5 Ensembl transcripts including schematic representations:
ENST00000415893  ENST00000468456  ENST00000462453  ENST00000308919  ENST00000340150  

Expression
for CYP2W1 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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CYP2W1 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for CYP2W1

1""  / 2""  / 3""

3 probe-sets matching CYP2W1 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
84033_at2, 3 U95-E 1 0.50 1.00 1.00 1.00 AI925040 0.80 1.00 0.91 1
220562_at2, 3 U133-A 1 0.64 1.00 -- -- NM_017781 0.60 1.00 0.82 1
220562_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
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Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.272795
Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2W1 ""
""SABiosciences RT2 qPCR Primer Assay for CYP2W1: PPH15517A ""

Orthologs
for CYP2W1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CYP2W1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC4916011   -- similar to cytochrome P450, family 2, subfamily W, more 83.27(n)
84.69(a)		 491601  XM_548722.2  XP_548722.2 
chimpanzee
(Pan troglodytes)		 CYP2W11   -- cytochrome P450, family 2, subfamily W, polypeptide more 98.57(n)
98.57(a)		 463213  XM_518926.2  XP_518926.2 
rat
(Rattus norvegicus)		 Cyp2w11   -- cytochrome P450, family 2, subfamily W, polypeptide more 77.39(n)
77.05(a)		 288517  XM_221971.4  XP_221971.3 
mouse
(Mus musculus)		 Cyp2w15
Cyp2w11		 55
 cytochrome P450, family 2, subfamily w, polypeptide more1, 5 78.46(n)1
77.91(a)1		 5458171  XM_620268.41  XP_620268.41 
 CF7291185 
chicken
(Gallus gallus)		 LOC4164541   -- similar to cytochrome P450, family 2, subfamily W, more 61.6(n)
55.65(a)		 416454  XM_414762.2  XP_414762.2 
About this table        Species with no ortholog for CYP2W1

ENSEMBL Gene Tree for CYP2W1

Paralogs
for CYP2W1 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for CYP2W1 gene
CYP2C82  CYP2G1P2  CYP2F12  CYP2R12  CYP2U12  CYP2J22  CYP2E12  CYP2D62  
CYP2D7P12  CYP2A62  CYP2B62  CYP2C192  CYP2S12  CYP2C92  CYP2C182  CYP2A132  

"" CYP2W1 for paralogs           About GeneDecksing


Genomic Variants
for CYP2W1 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/75 NCBI SNPs in CYP2W1 are shown (see all 75 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 17)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs788272731,2
C,F938606(+) CTCTGC/TGGTTC 1 -- ng51""1Minor allele frequency- T:0.17EA 88""
""
rs37356841,2
C,F1024855(-) GAGCGC/TGAAGG 2 T A mis1 ref1""10Minor allele frequency- T:0.02EA NA NS WA 2166""
--
rs38083481,2
C,F1028448(-) GCCTGG/AGCACC 2 /P /L ref1 mis1 ese3""11Minor allele frequency- A:0.04NS EA NA 998""
--
rs793644151,2
C,F1026768(+) GTTTGC/TTGAGG 2 A V ref1 mis1""1Minor allele frequency- T:0.02EA 88""
--
rs574922821,2
C,F938519(+) GAGGCG/ATGCAA 1 -- ng51""2Minor allele frequency- A:0.04NA EA 160""
--
rs97690881,2
C,A946222(+) ggtggC/Tggcgt 1 -- ng31""1Minor allele frequency- T:0.00NA 2""
""
rs127012201,2
C,F939387(+) GCTCGT/CTCCAC 1 -- ng51""7Minor allele frequency- C:0.22NS EA NA 474""
--
rs732579971,2
H937499(+) GGCAGA/GAGGAT 1 -- ng51""0--------
--
rs617463471,2
C1024871(+) CGGCCA/GCCGAT 2 H R mis1 ref1""0--------
--
rs767899521,2
F938441(+) CTCCCT/CCCCCG 1 -- ng51""1Minor allele frequency- C:0.11EA 88""
About this table

HapMap Linkage Disequilibrium images for CYP2W1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
      Database of Genomic Variants (DGV) variations for CYP2W1: --

Disorders & Mutations
for CYP2W1 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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4 ""Novoseek disease relationships for CYP2W1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
colon tumor 17.24 7 17979506 (6), 16426568 (1)
colon cancer 2.21 2 17979506 (2)
adrenal tumor 2.05 1 16426568 (1)
cancer 0.42 3 19596602 (1), 17979506 (1), 16426568 (1)
About this table

Locus Specific Mutation Databases: CYP2W1
Human Genome Epidemiology Navigator: CYP2W1 (1 document)

Medical News
for CYP2W1 gene

(Possibly Related Articles in Doctor's Guide)
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Publications
for CYP2W1 gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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  User Feedback		8 PubMed articles for CYP2W1 gene:

Search for CYP2W1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Search String
Free Text  
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Genome Databases showing CYP2W1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54905 HGNC: 20243 AceView: CYP2W1 Ensembl:ENSG00000073067 euGenes: HUgn54905
ECgene: CYP2W1 H-InvDB: CYP2W1

Other Databases showing CYP2W1 gene

(According to HUGE)
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Specialized Databases showing CYP2W1 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property
for CYP2W1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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  User Feedback		Patent Information for CYP2W1 gene: ""
Search GeneIP for patents involving CYP2W1

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


Services
for CYP2W1 gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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acyl-CoA synthetase family member 3
GIFtS Group
The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CYP2W1 gene at Home site.
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