Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYP2W1 Gene

Aliases for CYP2W1 Gene

  • Cytochrome P450 Family 2 Subfamily W Member 1 2 3 5
  • Cytochrome P450, Family 2, Subfamily W, Polypeptide 1 2 3
  • CYPIIW1 3 4
  • Cytochrome P450 2W1 3
  • EC 1.14.14.1 61
  • EC 1.14.14.5 61
  • EC 1.14.14.- 4

External Ids for CYP2W1 Gene

Previous GeneCards Identifiers for CYP2W1 Gene

  • GC00U916974
  • GC07P000796
  • GC07P000989
  • GC07P000939
  • GC07P001022

Summaries for CYP2W1 Gene

Entrez Gene Summary for CYP2W1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2W1 Gene

CYP2W1 (Cytochrome P450 Family 2 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2F1.

UniProtKB/Swiss-Prot for CYP2W1 Gene

  • Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).

Gene Wiki entry for CYP2W1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2W1 Gene

Genomics for CYP2W1 Gene

Regulatory Elements for CYP2W1 Gene

Enhancers for CYP2W1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G000971 1.9 FANTOM5 Ensembl ENCODE dbSUPER 45.7 -6.9 -6913 8.8 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 ENSG00000225146 C7orf50 COX19 LOC101927021 GPER1
GH07G000981 1.6 Ensembl ENCODE dbSUPER 44.7 +2.1 2143 7.1 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 YBX1 ZBTB7B ZNF143 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 COX19 ENSG00000225146 C7orf50 LOC101927021 GC07M001007
GH07G000990 1.4 Ensembl ENCODE 41.1 +9.0 9036 3.4 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CYP2W1 LOC105375120 GPR146 GC07M001007
GH07G001022 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25 +43.3 43317 7.4 HDGF FOXA2 MLX CREB3L1 ARNT AGO1 WRNIP1 SIN3A ARID4B DMAP1 LOC105375120 LOC101927021 CYP2W1 ZFAND2A COX19 GPER1 FAM20C PIR42102 MIR339
GH07G000962 1.3 Ensembl ENCODE dbSUPER 25.3 -18.7 -18655 3.4 ELF3 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF48 RAD21 GLIS2 CREM CYP2W1 LOC101927021 LOC105375120 C7orf50 ZFAND2A COX19 GPER1 PIR60263 PIR61474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP2W1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2W1 Gene

Chromosome:
7
Start:
983,156 bp from pter
End:
989,640 bp from pter
Size:
6,485 bases
Orientation:
Plus strand

Genomic View for CYP2W1 Gene

Genes around CYP2W1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2W1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2W1 Gene

Proteins for CYP2W1 Gene

  • Protein details for CYP2W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAV3-CP2W1_HUMAN
    Recommended name:
    Cytochrome P450 2W1
    Protein Accession:
    Q8TAV3

    Protein attributes for CYP2W1 Gene

    Size:
    490 amino acids
    Molecular mass:
    53844 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2W1 Gene

Selected DME Specific Peptides for CYP2W1 Gene

Q8TAV3:
  • EAFLPFS
  • PGPRPLP
  • KIEEVRA
  • AGTETTS

Post-translational modifications for CYP2W1 Gene

  • Glycosylation at Asn177
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP2W1 Gene

Domains & Families for CYP2W1 Gene

Gene Families for CYP2W1 Gene

Protein Domains for CYP2W1 Gene

Suggested Antigen Peptide Sequences for CYP2W1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAV3

UniProtKB/Swiss-Prot:

CP2W1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2W1: view

Function for CYP2W1 Gene

Molecular function for CYP2W1 Gene

UniProtKB/Swiss-Prot Function:
Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).

Enzyme Numbers (IUBMB) for CYP2W1 Gene

Gene Ontology (GO) - Molecular Function for CYP2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP2W1: view
genes like me logo Genes that share phenotypes with CYP2W1: view

Animal Model Products

CRISPR Products

miRNA for CYP2W1 Gene

miRTarBase miRNAs that target CYP2W1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2W1 Gene

Localization for CYP2W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2W1 Gene

Endoplasmic reticulum lumen. Cell membrane. Note=About 8% are expressed on the cell surface. {ECO:0000269 PubMed:20805301}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2W1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CYP2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IDA,IEA 20805301
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 20805301
genes like me logo Genes that share ontologies with CYP2W1: view

Pathways & Interactions for CYP2W1 Gene

genes like me logo Genes that share pathways with CYP2W1: view

Gene Ontology (GO) - Biological Process for CYP2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process IDA 16551781
GO:0019373 epoxygenase P450 pathway IBA --
GO:0043390 aflatoxin B1 metabolic process IDA 16551781
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP2W1: view

No data available for SIGNOR curated interactions for CYP2W1 Gene

Drugs & Compounds for CYP2W1 Gene

(1) Drugs for CYP2W1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYP2W1: view

Transcripts for CYP2W1 Gene

Unigene Clusters for CYP2W1 Gene

Cytochrome P450, family 2, subfamily W, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2W1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5:

Relevant External Links for CYP2W1 Gene

GeneLoc Exon Structure for
CYP2W1
ECgene alternative splicing isoforms for
CYP2W1

Expression for CYP2W1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2W1 Gene

mRNA differential expression in normal tissues according to GTEx for CYP2W1 Gene

This gene is overexpressed in Adrenal Gland (x17.2), Skin - Not Sun Exposed (Suprapubic) (x9.4), Skin - Sun Exposed (Lower leg) (x7.3), and Nerve - Tibial (x6.7).

Protein differential expression in normal tissues from HIPED for CYP2W1 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP2W1 Gene



Protein tissue co-expression partners for CYP2W1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP2W1 Gene:

CYP2W1

SOURCE GeneReport for Unigene cluster for CYP2W1 Gene:

Hs.272795

mRNA Expression by UniProt/SwissProt for CYP2W1 Gene:

Q8TAV3-CP2W1_HUMAN
Tissue specificity: Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors.

Evidence on tissue expression from TISSUES for CYP2W1 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with CYP2W1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2W1 Gene

Orthologs for CYP2W1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP2W1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2W1 34 35
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia CYP2W1 34 35
  • 83.23 (n)
cow
(Bos Taurus)
Mammalia LOC618939 34
  • 81.77 (n)
CYP2W1 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2w1 34 16 35
  • 78.65 (n)
rat
(Rattus norvegicus)
Mammalia Cyp2w1 34
  • 77.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYP2W1 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP2W1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP2W1 34 35
  • 61.91 (n)
lizard
(Anolis carolinensis)
Reptilia CYP2W1 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyp2k16 35
  • 40 (a)
OneToMany
cyp2k17 35
  • 40 (a)
OneToMany
cyp2k19 35
  • 40 (a)
OneToMany
cyp2k6 35
  • 40 (a)
OneToMany
cyp2k8 35
  • 40 (a)
OneToMany
cyp2k21 35
  • 39 (a)
OneToMany
cyp2k22 35
  • 39 (a)
OneToMany
cyp2k18 35
  • 38 (a)
OneToMany
cyp2k20 35
  • 38 (a)
OneToMany
cyp2k31 35
  • 38 (a)
OneToMany
Species where no ortholog for CYP2W1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP2W1 Gene

ENSEMBL:
Gene Tree for CYP2W1 (if available)
TreeFam:
Gene Tree for CYP2W1 (if available)

Paralogs for CYP2W1 Gene

Variants for CYP2W1 Gene

Sequence variations from dbSNP and Humsavar for CYP2W1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000364274 -- 986,510(+) CCAGC(A/G)CATCC intron-variant
rs1000379585 -- 983,726(+) GGGCC(G/T)GTCGG intron-variant
rs1000530616 -- 989,336(+) AGACT(C/G)TGAGC intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1000742327 -- 985,846(+) ACGGC(C/T)GGACC intron-variant
rs1000862456 -- 987,683(+) AGCAG(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2W1 Gene

Variant ID Type Subtype PubMed ID
esv3571557 CNV loss 25503493
esv3571559 CNV loss 25503493
nsv1024118 CNV gain 25217958
nsv1028282 CNV gain 25217958
nsv1161477 CNV deletion 26073780
nsv464245 CNV gain 19166990
nsv477026 CNV novel sequence insertion 20440878
nsv482099 CNV gain 20164927
nsv509182 CNV insertion 20534489
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv605720 CNV loss 21841781
nsv950784 CNV deletion 24416366

Variation tolerance for CYP2W1 Gene

Gene Damage Index Score: 6.66; 78.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2W1 Gene

Human Gene Mutation Database (HGMD)
CYP2W1
The Human Cytochrome P450 Allele Nomenclature Database
CYP2W1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2W1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2W1 Gene

Disorders for CYP2W1 Gene

Relevant External Links for CYP2W1

Genetic Association Database (GAD)
CYP2W1
Human Genome Epidemiology (HuGE) Navigator
CYP2W1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2W1

No disorders were found for CYP2W1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2W1 Gene

Publications for CYP2W1 Gene

  1. CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk. (PMID: 20602611) Gervasini G. … AgA_ndez J.A. (Pharmacogenomics 2010) 3 4 46 64
  2. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. (PMID: 16551781) Wu Z.L. … Guengerich F.P. (Mol. Pharmacol. 2006) 3 4 22 64
  3. Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. (PMID: 22591743) Xiao Y. … Guengerich F.P. (J. Lipid Res. 2012) 3 4 64
  4. Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity. (PMID: 20805301) Gomez A. … Ingelman-Sundberg M. (Mol. Pharmacol. 2010) 3 4 64
  5. Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. (PMID: 16426568) Karlgren M. … Ingelman-Sundberg M. (Biochem. Biophys. Res. Commun. 2006) 3 4 64

Products for CYP2W1 Gene

Sources for CYP2W1 Gene

Content
Loading form....