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Aliases for CYP2W1 Gene

Aliases for CYP2W1 Gene

  • Cytochrome P450, Family 2, Subfamily W, Polypeptide 1 2 3
  • CYPIIW1 3 4
  • Cytochrome P450 2W1 3
  • EC 1.14.14.1 63
  • EC 1.14.14.5 63
  • EC 1.14.14.- 4

External Ids for CYP2W1 Gene

Previous GeneCards Identifiers for CYP2W1 Gene

  • GC00U916974
  • GC07P000796
  • GC07P000989
  • GC07P000939
  • GC07P001022

Summaries for CYP2W1 Gene

Entrez Gene Summary for CYP2W1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2W1 Gene

CYP2W1 (Cytochrome P450, Family 2, Subfamily W, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2W1 Gene

  • Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Actives also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).

Gene Wiki entry for CYP2W1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2W1 Gene

Genomics for CYP2W1 Gene

Regulatory Elements for CYP2W1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP2W1 Gene

Start:
980,464 bp from pter
End:
989,640 bp from pter
Size:
9,177 bases
Orientation:
Plus strand

Genomic View for CYP2W1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2W1 Gene

Proteins for CYP2W1 Gene

  • Protein details for CYP2W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAV3-CP2W1_HUMAN
    Recommended name:
    Cytochrome P450 2W1
    Protein Accession:
    Q8TAV3
    Secondary Accessions:

    Protein attributes for CYP2W1 Gene

    Size:
    490 amino acids
    Molecular mass:
    53844 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2W1 Gene

Proteomics data for CYP2W1 Gene at MOPED

Selected DME Specific Peptides for CYP2W1 Gene

Post-translational modifications for CYP2W1 Gene

No Post-translational modifications

Other Protein References for CYP2W1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for CYP2W1 Gene

Gene Families for CYP2W1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP2W1 Gene

Suggested Antigen Peptide Sequences for CYP2W1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAV3

UniProtKB/Swiss-Prot:

CP2W1_HUMAN :
  • Q8TAV3
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2W1: view

Function for CYP2W1 Gene

Molecular function for CYP2W1 Gene

UniProtKB/Swiss-Prot Function:
Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Actives also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).

Enzyme Numbers (IUBMB) for CYP2W1 Gene

Gene Ontology (GO) - Molecular Function for CYP2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA --
genes like me logo Genes that share ontologies with CYP2W1: view

Phenotypes for CYP2W1 Gene

GenomeRNAi human phenotypes for CYP2W1:
genes like me logo Genes that share phenotypes with CYP2W1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2W1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2W1 Gene

Localization for CYP2W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2W1 Gene

Endoplasmic reticulum lumen. Cell membrane. Note=About 8% are expressed on the cell surface. {ECO:0000269 PubMed:20805301}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2W1 Gene COMPARTMENTS Subcellular localization image for CYP2W1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005788 endoplasmic reticulum lumen IDA 20805301
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 20805301
genes like me logo Genes that share ontologies with CYP2W1: view

Pathways for CYP2W1 Gene

genes like me logo Genes that share pathways with CYP2W1: view

Pathways by source for CYP2W1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat

Interacting Proteins for CYP2W1 Gene

Gene Ontology (GO) - Biological Process for CYP2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0042738 exogenous drug catabolic process IBA --
GO:0043390 aflatoxin B1 metabolic process IDA 16551781
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CYP2W1: view

Compounds for CYP2W1 Gene

(1) HMDB Compounds for CYP2W1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with CYP2W1: view

Transcripts for CYP2W1 Gene

Unigene Clusters for CYP2W1 Gene

Cytochrome P450, family 2, subfamily W, polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2W1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2W1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5:

Relevant External Links for CYP2W1 Gene

GeneLoc Exon Structure for
CYP2W1
ECgene alternative splicing isoforms for
CYP2W1

Expression for CYP2W1 Gene

mRNA expression in normal human tissues for CYP2W1 Gene

mRNA differential expression in normal tissues according to GTEx for CYP2W1 Gene

This gene is overexpressed in Adrenal Gland (17.2), Skin - Not Sun Exposed (Suprapubic) (9.4), Skin - Sun Exposed (Lower leg) (7.3), and Nerve - Tibial (6.7).

Protein differential expression in normal tissues for CYP2W1 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP2W1 Gene

SOURCE GeneReport for Unigene cluster for CYP2W1 Gene Hs.272795

mRNA Expression by UniProt/SwissProt for CYP2W1 Gene

Q8TAV3-CP2W1_HUMAN
Tissue specificity: Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors.
genes like me logo Genes that share expressions with CYP2W1: view

Expression partners for CYP2W1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CYP2W1 Gene

Orthologs for CYP2W1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP2W1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC618939 35
  • 81.77 (n)
  • 80.98 (a)
CYP2W1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2W1 35
  • 83.23 (n)
  • 84.93 (a)
CYP2W1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2w1 35
  • 78.65 (n)
  • 77.87 (a)
Cyp2w1 16
Cyp2w1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYP2W1 35
  • 98.64 (n)
  • 98.78 (a)
CYP2W1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2w1 35
  • 77.61 (n)
  • 77.4 (a)
oppossum
(Monodelphis domestica)
Mammalia CYP2W1 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYP2W1 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP2W1 35
  • 61.91 (n)
  • 55.96 (a)
CYP2W1 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP2W1 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyp2k16 36
  • 40 (a)
OneToMany
cyp2k17 36
  • 40 (a)
OneToMany
cyp2k18 36
  • 38 (a)
OneToMany
cyp2k19 36
  • 40 (a)
OneToMany
cyp2k20 36
  • 38 (a)
OneToMany
cyp2k21 36
  • 39 (a)
OneToMany
cyp2k22 36
  • 39 (a)
OneToMany
cyp2k31 36
  • 38 (a)
OneToMany
cyp2k6 36
  • 40 (a)
OneToMany
cyp2k8 36
  • 40 (a)
OneToMany
Species with no ortholog for CYP2W1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP2W1 Gene

ENSEMBL:
Gene Tree for CYP2W1 (if available)
TreeFam:
Gene Tree for CYP2W1 (if available)

Paralogs for CYP2W1 Gene

Pseudogenes.org Pseudogenes for CYP2W1 Gene

genes like me logo Genes that share paralogs with CYP2W1: view

Variants for CYP2W1 Gene

Sequence variations from dbSNP and Humsavar for CYP2W1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs879745 -- 986,006(-) GGGCC(C/T)GCCTG intron-variant
rs2091482 -- 985,642(-) GGGGG(A/G)CAGAC intron-variant
rs2272375 -- 983,377(+) GGTCC(C/T)TGATG reference, synonymous-codon
rs3735681 -- 986,152(-) GTCCG(C/T)GATCG intron-variant
rs3735683 -- 985,897(-) ATCAC(A/G)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2W1 Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
dgv7080n71 CNV Loss 21882294
nsv509182 CNV Insertion 20534489
nsv464245 CNV Gain 19166990
nsv887140 CNV Loss 21882294
nsv887141 CNV Loss 21882294
nsv887142 CNV Gain 21882294
dgv7081n71 CNV Loss 21882294
dgv7082n71 CNV Loss 21882294
dgv7083n71 CNV Loss 21882294
nsv887149 CNV Loss 21882294
dgv7084n71 CNV Loss 21882294
dgv7085n71 CNV Loss 21882294
nsv482099 CNV Gain 20164927

Relevant External Links for CYP2W1 Gene

HapMap Linkage Disequilibrium report
CYP2W1
Human Gene Mutation Database (HGMD)
CYP2W1
Locus Specific Mutation Databases (LSDB)
CYP2W1
The Human Cytochrome P450 Allele Nomenclature Database
CYP2W1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2W1 Gene

Disorders for CYP2W1 Gene

Relevant External Links for CYP2W1

Genetic Association Database (GAD)
CYP2W1
Human Genome Epidemiology (HuGE) Navigator
CYP2W1

No disorders were found for CYP2W1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CYP2W1 Gene

Publications for CYP2W1 Gene

  1. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. (PMID: 16551781) Wu Z.L. … Guengerich F.P. (Mol. Pharmacol. 2006) 3 4 23
  2. CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk. (PMID: 20602611) Gervasini G. … AgA_ndez J.A. (Pharmacogenomics 2010) 3 4 48
  3. Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity. (PMID: 20805301) Gomez A. … Ingelman-Sundberg M. (Mol. Pharmacol. 2010) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. (PMID: 16426568) Karlgren M. … Ingelman-Sundberg M. (Biochem. Biophys. Res. Commun. 2006) 3 4

Products for CYP2W1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP2W1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2W1
    • Block miRNA regulation of CYP2W1 using miScript Target Protectors

    Sources for CYP2W1 Gene

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