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Aliases for CYP2S1 Gene

Aliases for CYP2S1 Gene

  • Cytochrome P450 Family 2 Subfamily S Member 1 2 3 5
  • Cytochrome P450, Family 2, Subfamily S, Polypeptide 1 2 3
  • EC 4 63
  • CYPIIS1 3 4
  • Cytochrome P450, Subfamily IIS, Polypeptide 1 2
  • Cytochrome P540, Subfamily IIS, Polypeptide 1 3

External Ids for CYP2S1 Gene

Previous GeneCards Identifiers for CYP2S1 Gene

  • GC19P042338
  • GC19P042090
  • GC19P046375
  • GC19P046390
  • GC19P046391
  • GC19P041699
  • GC19P038131

Summaries for CYP2S1 Gene

Entrez Gene Summary for CYP2S1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2S1 Gene

CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and nicotine degradation IV. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2S1 Gene

  • Has a potential importance for extrahepatic xenobiotic metabolism.

Gene Wiki entry for CYP2S1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2S1 Gene

Genomics for CYP2S1 Gene

Regulatory Elements for CYP2S1 Gene

Enhancers for CYP2S1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP2S1 on UCSC Golden Path with GeneCards custom track

Promoters for CYP2S1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYP2S1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2S1 Gene

41,193,049 bp from pter
41,207,539 bp from pter
14,491 bases
Plus strand

Genomic View for CYP2S1 Gene

Genes around CYP2S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2S1 Gene

Proteins for CYP2S1 Gene

  • Protein details for CYP2S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 2S1
    Protein Accession:
    Secondary Accessions:
    • Q9BZ66

    Protein attributes for CYP2S1 Gene

    504 amino acids
    Molecular mass:
    55817 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP2S1 Gene


neXtProt entry for CYP2S1 Gene

Proteomics data for CYP2S1 Gene at MOPED

Selected DME Specific Peptides for CYP2S1 Gene

Post-translational modifications for CYP2S1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2S1 Gene

Domains & Families for CYP2S1 Gene

Gene Families for CYP2S1 Gene

Suggested Antigen Peptide Sequences for CYP2S1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2S1: view

Function for CYP2S1 Gene

Molecular function for CYP2S1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Has a potential importance for extrahepatic xenobiotic metabolism.

Enzyme Numbers (IUBMB) for CYP2S1 Gene

Gene Ontology (GO) - Molecular Function for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008401 retinoic acid 4-hydroxylase activity TAS --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP2S1: view
genes like me logo Genes that share phenotypes with CYP2S1: view

Animal Models for CYP2S1 Gene

MGI Knock Outs for CYP2S1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP2S1

miRNA for CYP2S1 Gene

miRTarBase miRNAs that target CYP2S1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2S1 Gene

Localization for CYP2S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2S1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CYP2S1 Gene COMPARTMENTS Subcellular localization image for CYP2S1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2S1 Gene

Pathways & Interactions for CYP2S1 Gene

genes like me logo Genes that share pathways with CYP2S1: view

Gene Ontology (GO) - Biological Process for CYP2S1 Gene


No data available for SIGNOR curated interactions for CYP2S1 Gene

Drugs & Compounds for CYP2S1 Gene

(17) Drugs for CYP2S1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 497
Codeine Approved, Illicit Pharma Full agonist, Agonist 69
Estradiol Approved, Investigational Pharma Sex hormone 1235
Estrone Approved Pharma Agonist Estrogenic hormone 19
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519

(26) Additional Compounds for CYP2S1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2S1: view

Transcripts for CYP2S1 Gene

Unigene Clusters for CYP2S1 Gene

Cytochrome P450, family 2, subfamily S, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2S1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3: -
SP4: - - - - -

Relevant External Links for CYP2S1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP2S1 Gene

mRNA expression in normal human tissues for CYP2S1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2S1 Gene

This gene is overexpressed in Stomach (x13.9), Small Intestine - Terminal Ileum (x5.8), Esophagus - Mucosa (x4.5), and Colon - Transverse (x4.5).

Protein differential expression in normal tissues from HIPED for CYP2S1 Gene

This gene is overexpressed in Nasal epithelium (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP2S1 Gene

SOURCE GeneReport for Unigene cluster for CYP2S1 Gene Hs.98370

mRNA Expression by UniProt/SwissProt for CYP2S1 Gene

Tissue specificity: High level of expression in trachea, lung, stomach, small intestine, and spleen.
genes like me logo Genes that share expression patterns with CYP2S1: view

Primer Products

No data available for Protein tissue co-expression partners for CYP2S1 Gene

Orthologs for CYP2S1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2S1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYP2S1 35
  • 84.11 (n)
  • 79.72 (a)
CYP2S1 36
  • 80 (a)
(Canis familiaris)
Mammalia CYP2S1 35
  • 84.99 (n)
  • 81.74 (a)
CYP2S1 36
  • 65 (a)
(Mus musculus)
Mammalia Cyp2s1 35
  • 80.76 (n)
  • 78.75 (a)
Cyp2s1 16
Cyp2s1 36
  • 78 (a)
(Pan troglodytes)
Mammalia LOC739649 35
  • 99.57 (n)
  • 99.49 (a)
CYP2S1 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Cyp2s1 35
  • 79.01 (n)
  • 77.13 (a)
(Monodelphis domestica)
Mammalia CYP2S1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia CYP2S1 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 37
  • 28 (a)
(Caenorhabditis elegans)
Secernentea B0213.15 37
  • 30 (a)
T10H4.10 37
  • 32 (a)
Species with no ortholog for CYP2S1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2S1 Gene

Gene Tree for CYP2S1 (if available)
Gene Tree for CYP2S1 (if available)

Paralogs for CYP2S1 Gene

genes like me logo Genes that share paralogs with CYP2S1: view

Variants for CYP2S1 Gene

Sequence variations from dbSNP and Humsavar for CYP2S1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34971233 - 41,206,370(+) GAGCC(C/T)GTGCC nc-transcript-variant, reference, missense
rs8100811 -- 41,200,395(+) tgaga(C/T)gaagt intron-variant
rs12984125 -- 41,205,384(+) tttct(C/T)tctct intron-variant
rs12984386 -- 41,205,482(+) ttctt(C/T)cttcc intron-variant
rs12984393 -- 41,205,489(+) ttcct(C/T)ccttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2S1 Gene

Variant ID Type Subtype PubMed ID
nsv911767 CNV Loss 21882294
nsv523521 CNV Loss 19592680
nsv911768 CNV Loss 21882294

Variation tolerance for CYP2S1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2S1 Gene

The Human Cytochrome P450 Allele Nomenclature Database

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2S1 Gene

Disorders for CYP2S1 Gene

Relevant External Links for CYP2S1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYP2S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2S1 Gene

Publications for CYP2S1 Gene

  1. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). (PMID: 11181079) Rylander T. … Oscarson M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. (PMID: 19713358) Bui P.H. … Hankinson O. (Mol. Pharmacol. 2009) 3 23
  3. CYP2S1 gene polymorphisms in a Korean population. (PMID: 17529885) Jang Y.J. … Shin J.G. (Ther Drug Monit 2007) 3 23
  4. CYP2S1 depletion enhances colorectal cell proliferation is associated with PGE2-mediated activation of I^-catenin signaling. (PMID: 25557876) Yang C. … Wan C. (Exp. Cell Res. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CYP2S1 Gene

Sources for CYP2S1 Gene