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CYP2S1 Gene

protein-coding   GIFtS: 66
GCID: GC19P041699

Cytochrome P450, Family 2, Subfamily S, Polypeptide 1

(Previous names: cytochrome P450, subfamily IIS, polypeptide 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily S, Polypeptide 11 2     Cytochrome P450 2S12
CYPIIS12 3     Cytochrome P450 Family Member Predicted From ESTs2
EC 1.14.14.13 8     Cytochrome P540, Subfamily IIS, Polypeptide 12
Cytochrome P450, Subfamily IIS, Polypeptide 11     

External Ids:    HGNC: 156541   Entrez Gene: 297852   Ensembl: ENSG000001676007   OMIM: 6115295   UniProtKB: Q96SQ93   

Export aliases for CYP2S1 gene to outside databases

Previous GC identifers: GC19P042338 GC19P042090 GC19P046375 GC19P046390 GC19P046391 GC19P038131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2S1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has
been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2S1 Gene:
CYP2S1 (cytochrome P450, family 2, subfamily S, polypeptide 1) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
Function: Has a potential importance for extrahepatic xenobiotic metabolism

Gene Wiki entry for CYP2S1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2S1 gene promoter:
         AREB6   HEN1   AhR   HOXA5   ATF-2   AP-4   c-Jun   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2S1 promoter sequence
   Search Chromatin IP Primers for CYP2S1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2S1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2S1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2S1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041699:  view genomic region     (about GC identifiers)

Start:
41,698,954 bp from pter      End:
41,713,444 bp from pter
Size:
14,491 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9 (See protein sequence)
Recommended Name: Cytochrome P450 2S1  
Size: 504 amino acids; 55817 Da
Cofactor: Heme group (By similarity)
Secondary accessions: Q9BZ66
Alternative splicing: 2 isoforms:  Q96SQ9-1   Q96SQ9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP2S1: NX_Q96SQ9

Explore proteomics data for CYP2S1 at MOPED

4 DME Specific Peptides for CYP2S1 (Q96SQ9)
 EAFLPFS  PGPTPLP  EEFSGRG  ELFLFFTTILQ 


See CYP2S1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_085125.1  
ENSEMBL proteins: 
 ENSP00000308032   ENSP00000471637   ENSP00000472555   ENSP00000471016   ENSP00000469593  
 ENSP00000469850   ENSP00000445299  
Reactome Protein details: Q96SQ9

CYP2S1 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for CYP2S1

 
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antibodies-online proteins for CYP2S1 (2 products) 

 
antibodies-online peptides for CYP2S1

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antibodies-online antibodies for CYP2S1 (34 products) 

CYP2S1 Assay Products:

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antibodies-online kits for CYP2S1 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2S1
CYP2 family

4 InterPro protein domains:
 IPR001128 Cyt_P450
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I
 IPR008067 Cyt_P450_E_grp-I_CYP2A-like

Graphical View of Domain Structure for InterPro Entry Q96SQ9

ProtoNet protein and cluster: Q96SQ9

2 Blocks protein domains:
IPB002401 E-class P450 group I signature
IPB008067 CYP2A P450 family signature


UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
Similarity: Belongs to the cytochrome P450 family


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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CP2S1_HUMAN, Q96SQ9
Function: Has a potential importance for extrahepatic xenobiotic metabolism
Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

     Enzyme Number (IUBMB): EC 1.14.14.11 2

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004497monooxygenase activity ----
GO:0005506iron ion binding IEA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
GO:0020037heme binding IEA--
GO:0070330aromatase activity IEA--
     
Find genes that share ontologies with CYP2S1           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for CYP2S1:
 Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Increased number of cells in m 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cyp2s1):
 normal 

Find genes that share phenotypes with CYP2S1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cyp2s1tm1Ding for CYP2S1

   genOway: Develop your customized and physiologically relevant rodent model for CYP2S1

miRNA
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hsa-miR-194* hsa-miR-647
SwitchGear 3'UTR luciferase reporter plasmidCYP2S1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for CYP2S1
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2S1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CP2S1_HUMAN, Q96SQ9: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
extracellular2
golgi apparatus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum ----
GO:0005789endoplasmic reticulum membrane TAS--
GO:0043231intracellular membrane-bounded organelle ----

Find genes that share ontologies with CYP2S1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CYP2S1 About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type0.75
Xenobiotics0.00
Phase 1 - Functionalization of compounds0.75
Miscellaneous substrates0.00
cytochrome P4500.74
CYP2E1 reactions0.00
2Biological oxidations
Biological oxidations0.56
metapathway biotransformation0.42
3acetone degradation I (to methylglyoxal)
bupropion degradation0.44
nicotine degradation IV0.33
acetone degradation I (to methylglyoxal)0.44
nicotine degradation III0.00
4tryptophan utilization II
tryptophan utilization I0.71
melatonin degradation I0.00
superpathway of melatonin degradation0.00
5Chemical carcinogenesis
Metabolism of xenobiotics by cytochrome P4500.71
Retinol metabolism0.35


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for CYP2S1
    Naphthalene metabolism

Selected BioSystems Pathways for CYP2S1 (see all 9)
    cytochrome P450
nicotine degradation IV
nicotine degradation III
bupropion degradation
melatonin degradation I


3 Reactome Pathways for CYP2S1
    Miscellaneous substrates
Xenobiotics
CYP2E1 reactions


2 Kegg Pathways  (Kegg details for CYP2S1):
    Retinol metabolism
Metabolism of xenobiotics by cytochrome P450

    Pathway & Disease-focused RT2 Profiler PCR Array including CYP2S1: 
          Drug Metabolism: Phase I Enzymes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CYP2S1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CYP2S1 (Q96SQ93 ENSP000003080324) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
InteractantInteraction Details
GeneCardExternal ID(s)
ADAMTSL4Q6UY143I2D: score=1 
FYCO1Q9BQS83I2D: score=1 
CYP2E1ENSP000002529454STRING: ENSP00000252945
CYP2U1ENSP000003332124STRING: ENSP00000333212
CYP4X1ENSP000003609684STRING: ENSP00000360968
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006805xenobiotic metabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:0055114oxidation-reduction process ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CYP2S1 (CP2S1)

Selected HMDB Compounds for CYP2S1 (see all 49)    About this table
CompoundSynonyms CAS #PubMed Ids
10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
12,13-EpOMEVernolic acid (see all 12)----
13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

2 Novoseek inferred chemical compound relationships for CYP2S1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
naphthalene 75.3 2 16054184 (1), 15987645 (1)
retinoic acid 49.4 1 15987645 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CYP2S1 gene: 
NM_030622.6  

Unigene Cluster for CYP2S1:

Cytochrome P450, family 2, subfamily S, polypeptide 1
Hs.98370  [show with all ESTs]
Unigene Representative Sequence: NM_030622
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000310054(uc002opw.3 uc010xvx.2) ENST00000597754 ENST00000593545
ENST00000600561 ENST00000595590 ENST00000593890 ENST00000542619
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hsa-miR-194* hsa-miR-647
SwitchGear 3'UTR luciferase reporter plasmidCYP2S1 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat CYP2S1

Additional mRNA sequence: 

AF335278.1 AK027605.1 AK296087.1 AY358603.1 BC033691.1 

6 DOTS entries:

DT.109819  DT.100776892  DT.97847700  DT.95299004  DT.91747679  DT.121435287 

Selected AceView cDNA sequences (see all 157):

AK027605 BM044172 AW351530 NM_030622 BM770714 BM770748 BM743865 BU552425 
BM044271 BM770694 BM756232 BM771424 BQ001642 BM771294 BM853712 AA301039 
BM739256 BM771940 BM771002 BM852089 AA579959 BM752045 BM771239 BM771818 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2S1    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1:        -                                                               
SP2:                    -     -     -                                       
SP3:                                                  -                     
SP4:        -     -     -     -     -                                       


ECgene alternative splicing isoforms for CYP2S1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CYP2S1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCCCTCTCT
CYP2S1 Expression
About this image


CYP2S1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
         Human embryonic stem cells (family)
 
 Ovary (Reproductive System)
         Secondary follicles
 
 NULL (Uncategorized)
         Mesenchymal Progenitor Cells - Passage 2
 
 Blood (Hematopoietic System)
         Monocytes Peripheral Blood
 
 Colon (Gastrointestinal Tract)
CYP2S1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CYP2S1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.98370

UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
Tissue specificity: High level of expression in trachea, lung, stomach, small intestine, and spleen

    Pathway & Disease-focused RT2 Profiler PCR Array including CYP2S1: 
          Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2S1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CYP2S1 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cyp2s11 , 5 cytochrome P450, family 2, subfamily s, polypeptide more1, 5 80.76(n)1
78.75(a)1
  7 (14.05 cM)5
741341  NM_028775.31  NP_083051.11 
 258024755 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
47(a)
many ↔ many
GL343830.1(83411-94389)


ENSEMBL Gene Tree for CYP2S1 (if available)
TreeFam Gene Tree for CYP2S1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CYP2S1 gene
CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  
CYP2J22  CYP2U12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  CYP2A132  
Selected SIMAP similar genes for CYP2S1 using alignment to 7 protein entries:     CP2S1_HUMAN (see all proteins) (see all similar genes):
CYP2G1P    CYP2B7    CYP2A13    CYP2A6    CYP2A6V2    CYP2B
CYP2A7    CYP2B6    CYP2C18    CYP2C9    CYP2F1    CYP2C19
CYP2C8    CYP 2C    CYP2E1    CYP2R1    CYP2U1    CYP2W1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CYP2S1 (see all 498)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1116782931,2
C--38137895(+) ATCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
rs561119891,2
C--38143268(+) TCTTTC/TTTTCT 1 -- int13Minor allele frequency- T:0.20NA CSA 5
rs798712351,2
C--38143275(+) TTTTTT/CTTTCT 1 -- int12Minor allele frequency- C:0.25NA 4
rs560753361,2
--38143297(+) TTTCTC/TTCTTT 1 -- int10--------
rs1996269231,2
--38143322(+) CTCTC-/TTTCTTT 1 -- int10--------
rs3747077751,2
C--38143348(+) TTTCT-/TCTCTC
        
CTCTC
1 -- int10--------
rs113119561,2
C--38143353(+) tttct-/C/    
   CTC
/T
tctct
2 -- int1 cds11NA 2
rs114610081,2
C--38143354(+) TCTCT-/CTCTCTCTTTCTT
TCTCTCTTTCTTG
/G
CTCTC
1 -- int10--------
rs2000822631,2
C--38143375(+) TTTTC-/TTTTTC 1 -- int10--------
rs576015321,2
C--41703604(+) TCTCA-/AAAAAA 1 -- int10--------

HapMap Linkage Disequilibrium report for CYP2S1 (41698954 - 41713444 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CYP2S1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv911768CNV Loss21882294
nsv911767CNV Loss21882294
nsv523521CNV Loss19592680

The Human Cytochrome P450 Allele Nomenclature Database: CYP2S1 
Locus Specific Mutation Databases (LSDB): CYP2S1

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CYP2S1
DNA2.0 Custom Variant and Variant Library Synthesis for CYP2S1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611529    OMIM disorders: --


Find genes that share disorders with CYP2S1           About GenesLikeMe

Genetic Association Database (GAD): CYP2S1
Human Genome Epidemiology (HuGE) Navigator: CYP2S1 (4 documents)

Export disorders for CYP2S1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CYP2S1 gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with CYP2S1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). (PubMed id 11181079)1, 2, 3, 9 Rylander T.... Oscarson M. (Biochem. Biophys. Res. Commun. 2001)
  2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
  3. Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals. (PubMed id 17495422)1, 4 Hanzawa Y....Mizugaki M. (Drug Metab. Pharmacokinet. 2007)
  4. Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population. (PubMed id 15450424)1, 4 Saarikoski S.T....Husgafvel-Pursiainen K. (Mutat. Res. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  8. CYP2S1 gene polymorphisms in a Korean population. (PubMed id 17529885)1, 9 Jang Y.J....Shin J.G. (Ther Drug Monit 2007)
  9. Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. (PubMed id 19713358)1, 9 Bui P.H. and Hankinson O. (Mol. Pharmacol. 2009)
  10. Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. (PubMed id 23224081)1 FrAPmel T....Fleming I. (Basic Res. Cardiol. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29785 HGNC: 15654 AceView: CYP2S1 Ensembl:ENSG00000167600 euGenes: HUgn29785
ECgene: CYP2S1 Kegg: 29785 H-InvDB: CYP2S1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CYP2S1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP2S1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CYP2S1 gene:
Search GeneIP for patents involving CYP2S1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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