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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP2S1 Gene

protein-coding   GIFtS: 64
GCID: GC19P041699

cytochrome P450, family 2, subfamily S, polypeptide 1

(Previous names: cytochrome P450, subfamily IIS, polypeptide 1 )
 Explore 5 diseases affiliated with
CYP2S1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYP2S1    

Aliases
for CYP2S1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome P450, Family 2, Subfamily S, Polypeptide 11 2     Cytochrome P450 2S12
Cytochrome P450, Subfamily IIS, Polypeptide 11 2     Cytochrome P450 Family Member Predicted From ESTs2
CYPIIS12 3     Cytochrome P540, Subfamily IIS, Polypeptide 12
EC 1.14.14.13 8     

External Ids:    HGNC: 156541   Entrez Gene: 297852   Ensembl: ENSG000001676007   OMIM: 6115295   UniProtKB: Q96SQ93   

Export aliases for CYP2S1 gene to outside databases

Previous GC identifers: GC19P042338 GC19P042090 GC19P046375 GC19P046390 GC19P046391 GC19P038131


Summaries
for CYP2S1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP2S1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown
to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
Function: Has a potential importance for extrahepatic xenobiotic metabolism

Gene Wiki entry for CYP2S1


Genomic Views
for CYP2S1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP2S1 gene promoter:
         AREB6   HEN1   AhR   HOXA5   ATF-2   AP-4   c-Jun   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2S1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP2S1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2S1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

CYP2S1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2S1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041699:  view genomic region     (about GC identifiers)

Start:
 41,699,115 bp from pter      End:
 41,713,444 bp from pter
Size:
 14,330 bases      Orientation:
 plus strand

Proteins
for CYP2S1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9 (See protein sequence)
Recommended Name: Cytochrome P450 2S1  
Size: 504 amino acids; 55817 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: Q9BZ66
Alternative splicing: 2 isoforms:  Q96SQ9-1   Q96SQ9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP2S1: NX_Q96SQ9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96SQ9

    • 4 DME Specific Peptides for CYP2S1 (Q96SQ9)
     EAFLPFS  PGPTPLP  EEFSGRG  ELFLFFTTILQ 

    CYP2S1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_085125.1  
    ENSEMBL proteins: 
     ENSP00000308032   ENSP00000445299  
    Reactome Protein details: Q96SQ9
    Human Recombinant Protein Products: 
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    Novus Biologicals CYP2S1 Lysate
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    Uscn Proteins for CYP2S1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum NAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----


    CYP2S1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CYP2S1

    Protein Domains /
    Families
    for CYP2S1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYP2S1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008067 Cyt_P450_E_grp-I_CYP2A-like

    Graphical View of Domain Structure for InterPro Entry Q96SQ9

    ProtoNet protein and cluster: Q96SQ9

    2 Blocks protein families:
    IPB002401 E-class P450 group I signature
    IPB008067 CYP2A P450 family signature


    UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
    Similarity: Belongs to the cytochrome P450 family


    Function
    for CYP2S1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
    Function: Has a potential importance for extrahepatic xenobiotic metabolism
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

    Enzyme Number (IUBMB): EC 1.14.14.11 2

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    SwitchGear 3'UTR luciferase reporter plasmid: CYP2S1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity NAS--
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--


    CYP2S1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CYP2S1:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Increased number of cells in m 

    Animal Models:
         Mouse knock-out Cyp2s1tm1Ding for CYP2S1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cyp2s1):
     normal 

    CYP2S1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CYP2S1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type1.00
    		cytochrome P4500.73
    		Phase 1 - Functionalization of compounds0.74
    2Xenobiotics
    		Xenobiotics1.00
    		CYP2E1 reactions0.65
    3Naphthalene metabolism
    		Naphthalene metabolism1.00
    		Naphthalene metabolism1.00
    4superpathway of melatonin degradation
    		superpathway of melatonin degradation1.00
    		melatonin degradation I0.85
    5nicotine degradation III
    		nicotine degradation III1.00
    		nicotine degradation IV0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CYP2S1
        Naphthalene metabolism


    1 GeneGo (Thomson Reuters) Pathway for CYP2S1
        Naphthalene metabolism

    5/8 BioSystems Pathways for CYP2S1 (see all 8) 
        cytochrome P450
    melatonin degradation I
    bupropion degradation
    nicotine degradation III
    nicotine degradation IV

    5/7        Reactome Pathways for CYP2S1 (see all 7)
        Cytochrome P450 - arranged by substrate type
    Miscellaneous substrates
    Xenobiotics
    Metabolism
    Biological oxidations


    1         Kegg Pathway  (Kegg details for CYP2S1):
        Metabolism of xenobiotics by cytochrome P450


    CYP2S1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2S1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for CYP2S1 (Q96SQ93 ENSP000003080324) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAMTSL4Q6UY143I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    CYP2E1ENSP000002529454STRING: ENSP00000252945
    CYP2U1ENSP000003332124STRING: ENSP00000333212
    CYP4X1ENSP000003609684STRING: ENSP00000360968
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process NAS--


    CYP2S1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYP2S1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP2S1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYP2S1

    10/49 HMDB Compounds for CYP2S1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    2 Novoseek chemical compound relationships for CYP2S1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naphthalene 75.3 2 16054184 (1), 15987645 (1)
    retinoic acid 49.4 1 15987645 (1)

    Search CenterWatch for drugs/clinical trials and news about CYP2S1 / CP2S1 

    Transcripts
    for CYP2S1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYP2S1 gene: 
    NM_030622.6  

    Unigene Cluster for CYP2S1:

    Cytochrome P450, family 2, subfamily S, polypeptide 1
    Hs.98370  [show with all ESTs]
    Unigene Representative Sequence: NM_030622
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310054(uc002opw.3 uc010xvx.2) ENST00000542619

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF335278.1 AK027605.1 AK296087.1 AY358603.1 BC033691.1 

    6 DOTS entries:

    DT.109819  DT.100776892  DT.97847700  DT.95299004  DT.91747679  DT.121435287 

    24/157 AceView cDNA sequences (see all 157):

    AA971278 BM770748 NM_030622 BM743865 BM760193 BM739256 BM770694 BM044271 
    AA301039 BQ001642 BM771424 BG123000 BM853712 AK027605 AW351530 BM771002 
    BM044172 BM771818 BQ928732 BU552425 BM756232 BM752045 BM771239 BM771940 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2S1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -                                                               
    SP2:                    -     -     -                                       
    SP3:                                                  -                     
    SP4:        -     -     -     -     -                                       


    ECgene alternative splicing isoforms for CYP2S1

    Expression
    for CYP2S1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP2S1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCCTCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CYP2S1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CYP2S1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP2S1

    SOURCE GeneReport for Unigene cluster: Hs.98370

    UniProtKB/Swiss-Prot: CP2S1_HUMAN, Q96SQ9
    Tissue specificity: High level of expression in trachea, lung, stomach, small intestine, and spleen

        SABiosciences Expression via Pathway-Focused PCR Array including CYP2S1: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    Orthologs
    for CYP2S1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CYP2S1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cyp2s11 , 5 cytochrome P450, family 2, subfamily s, polypeptide more1, 5 81.08(n)1
    78.99(a)1    		   7 (14.05 cM)5
    741341  NM_028775.31  NP_083051.11 
     258024755 
    lizard
    (Anolis carolinensis)    		 Reptilia CYP2A7P16
    --
    (see all 13)    		 --
    		 49(a)
    48(a)
    (see all 13)    		 many ↔ many
    possible ortholog
    (see all 13)    		 AAWZ02041178(4195-5719)
    LGf(2965993-2976553)
    zebrafish
    (Danio rerio)    		 Actinopterygii CU928854.16
    cyp2y36
    		 --
    cytochrome P450, family 2, subfamily Y, polypeptid...
    		 42(a)
    42(a)
    		 many ↔ many
    many ↔ many
    		 15(54297-58832)
    15(65144-71354)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cyp304a11 , 3 insecticide metabolism cytochrome P4503
    CG7241-PA1    		 28(a)3
    46.13(n)1
    31.22(a)1    		   87D53
    415861  NM_169484.11  NP_731751.11 


    ENSEMBL Gene Tree for CYP2S1 (if available)
    TreeFam Gene Tree for CYP2S1 (if available) 

    Paralogs
    for CYP2S1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP2S1 gene
    CYP2W12  CYP2C82  CYP2F12  CYP2A72  CYP2R12  CYP2J22  CYP2U12  CYP2E12  
    CYP2D62  CYP2B7P12  CYP2A62  CYP2B62  CYP2C192  CYP2C92  CYP2A132  CYP2C182  
    18/28 SIMAP similar genes for CYP2S1 using alignment to 7 protein entries:     CP2S1_HUMAN (see all proteins) (see all similar genes):
    CYP2G1P    CYP2B7    CYP2A13    CYP2A6    CYP2A6V2    CYP2B
    CYP2A7    CYP2F1    CYP2C18    CYP2B6    CYP2C9    CYP2C19
    CYP2C8    CYP 2C    CYP2E1    CYP2U1    CYP2W1    CYP2J2

    CYP2S1 for paralogs           About GeneDecksing



    Genomic Variants
    for CYP2S1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/382 NCBI SNPs in CYP2S1 are shown (see all 382)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs730432291,2
    		C,F,--38129833(+) TAATAA/GAATGG 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs739314411,2
    		C,--38129965(+) CAGCTT/GCCGTT 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs118787821,2
    		C,H,--38130280(+) CCAGAA/GCCCTT 1 -- us2k10--------
    rs766886091,2
    		--38130350(+) CCTCAA/GTAACA 1 -- us2k13Minor allele frequency- G:0.03CSA WA NA 240
    rs72495541,2
    		C,F,A,H,--38130710(+) CTCTCA/GGTTCG 1 -- us2k116Minor allele frequency- G:0.10NS EA NA WA CSA 1043
    rs739314421,2
    		C,--38130715(+) AGTTCG/ATGAAG 1 -- us2k12Minor allele frequency- A:0.12WA 120
    rs124601961,2
    		H--38131464(+) GGGAGG/CAGGCA 1 -- int1 trp34Minor allele frequency- C:0.00NS EA 384
    rs752748971,2
    		--38132255(+) TGGGGA/GATGCC 1 -- int10--------
    rs169750521,2
    		C,F,H,--38134652(+) GGGAAG/TGTCTG 1 -- int119Minor allele frequency- T:0.10NA NS EA WA CSA 1637
    rs735487521,2
    		C,F,--38134776(+) ATGGGA/GTGGGT 1 -- int14Minor allele frequency- G:0.18WA CSA 124

    HapMap Linkage Disequilibrium report for CYP2S1 (41699115 - 41713444 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CYP2S1
         4 CNVs: 89246 89247 78199 78198
    Locus Specific Mutation Databases (LSDB): CYP2S1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2S1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2S1

    Disorders / Diseases
    for CYP2S1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYP2S1 for disorders           About GeneDecksing

    OMIM gene information: 611529    OMIM disorders: --

    5 diseases for CYP2S1:    About MalaCards
    cholesterol    skin disease    psoriasis    hypoxia
    hepatitis

    Genetic Association Database (GAD): CYP2S1
    Human Genome Epidemiology (HuGE) Navigator: CYP2S1 (4 documents)

    Export disorders for CYP2S1 gene to outside databases

    Publications
    for CYP2S1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP2S1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with CYP2S1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). (PubMed id 11181079)1, 2, 3, 9 Rylander T.... Oscarson M. (2001)
    2. Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population. (PubMed id 15450424)1, 4 Saarikoski S.T....Husgafvel-Pursiainen K. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. CYP2S1 gene polymorphisms in a Korean population. (PubMed id 17529885)1, 9 Jang Y.J....Shin J.G. (2007)
    7. Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. (PubMed id 19713358)1, 9 Bui P.H. and Hankinson O. (2009)
    8. Characterization of a human keratinocyte HaCaT cell li ne model to study the regulation of CYP2S1. (PubMed id 22039172)1 McNeilly A.D....Smith G. (2012)
    9. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    10. [Polymorphic markers of the CYP1B1 (4326C > G), CY P2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induce d by smoking and occupational factors]. (PubMed id 22232929)1 Akhmadishina L.A....Victorova T.V. (2011)

    External Searches for CYP2S1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CYP2S1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29785 HGNC: 15654 AceView: CYP2S1 Ensembl:ENSG00000167600 euGenes: HUgn29785
    ECgene: CYP2S1 Kegg: 29785 H-InvDB: CYP2S1

    Other Databases showing CYP2S1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP2S1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP2S1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2S1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CYP2S1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP2S1 gene:
    Search GeneIP for patents involving CYP2S1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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