Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


CYP2R1 Gene

protein-coding   GIFtS: 56

GC11M014856
cytochrome P450, family 2, subfamily R, polypeptide 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for CYP2R1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
cytochrome P450, family 2, subfamily R, polypeptide 11 2
Cytochrome P450 2R12 3
vitamin D 25-hydroxylase2
MGC46632
cytochrome P450, family 2, R12
EC 1.14.13.153

External Ids:    HGNC: 205801   Entrez Gene: 1202272   Ensembl: ENSG000001861047   UniProtKB: Q6VVX03   

Search outside databases for aliases for CYP2R1 gene

Previous GC identifers: GC11M014938 GC11M014863 GC11M014876

Summaries
for CYP2R1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for CYP2R1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the
vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
(provided by RefSeq)

UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0
Function: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3)

Gene Wiki entry for CYP2R1

Genomic Views
for CYP2R1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CYP2R1 gene upstream (promoter) region "":
POU2F1   RSRFC4   GATA-1   MEF-2A   GATA-3   GATA-2   POU2F2C   oct-B2   oct-B3   POU2F2   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP2R1:  ""
MePH14842-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

CYP2R1 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M014856:  view genomic region     (about GC identifiers)

Start:
 14,899,555 bp from pter
End:
 14,913,751 bp from pter
Size:
 14,197 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

Proteins
for CYP2R1 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0 (See protein sequence)
Recommended Name: Vitamin D 25-hydroxylase  
Size: 501 amino acids; 57359 Da
Cofactor: Heme group (By similarity)
Subunit: Homodimer
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
PDB structures from "" and Proteopedia "" :
3C6G (3D) ""    3CZH (3D) ""    3DL9 (3D) ""    
Secondary accessions: Q2M3H3 Q5RT65

REFSEQ proteins: NP_078790.2  

ENSEMBL proteins: 
ENSP00000334592 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Enzo Life Sciences proteins for CYP2R1
""HuPro® and/or Recombinant Proteins from Abnova for CYP2R1 ""
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Novus Biologicals Protein for CYP2R1  ""
Novus Biologicals Lysates for CYP2R1
""Browse Sino Biological Recombinant Proteins  ""

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane EXP15465040
GO:0005792 microsome IEA--
GO:0016020 membrane IEA--
GO:0019898 extrinsic to membrane ----
About this table

"" CYP2R1 for ontologies           About GeneDecksing



Antibodies for CYP2R1: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for CYP2R1
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (CYP2R1)
""Browse Origene Antibodies ""
""Novus Biologicals Antibodies for CYP2R1
""Browse antibodies at Epitomics

Assays for CYP2R1: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Enzo Life Sciences assays for CYP2R1

Protein Domains/
Families
for CYP2R1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

  User Feedback
"" CYP2R1 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001128 Cyt_P450
 IPR017973 Cyt_P450_C
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q6VVX0

ProtoNet protein and cluster: Q6VVX0

1 Blocks protein family: IPB002401 E-class P450 group I signature

UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0
Similarity: Belongs to the cytochrome P450 family

Gene Function
for CYP2R1 gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
About This Section

  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CYP2R1
Origene shRNA RFP (see all 2): CYP2R1
Origene basic RS shRNA (see all 2): CYP2R1

""Applied Biosystems Silencer® siRNAs for CYP2R1
""Sigma-Aldrich siRNA Panels and siRNA for CYP2R1
Sigma-Aldrich shRNA for CYP2R1
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2R1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2R1
Origene untagged cDNA clones in CMV expression vector (see all 2): CYP2R1
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0
Function: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3)
Catalytic activity: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O(2) =
(25R)-5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP(+) + H(2)O
Biophysicochemical properties: Kinetic parameters: KM=0.67 uM for vitamin D(2); KM=0.45 uM for vitamin D(3);
Enzyme Number (IUBMB): EC 1.14.13.15 

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0004497 monooxygenase activity IEA--
GO:0005506 iron ion binding ----
GO:0009055 electron carrier activity IEA--
GO:0020037 heme binding IEA--
GO:0030343 vitamin D3 25-hydroxylase activity EXP15465040
About this table

"" CYP2R1 for ontologies           About GeneDecksing

Animal Models: 1 MGI phenotypic allele "" for Cyp2r1 (no phenotypes)


"" CYP2R1 for phenotypes           About GeneDecksing

Pathways & Interactions
for CYP2R1 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
About This Section

  User Feedback
"" CYP2R1 for pathways           About GeneDecksing

1 "" Millipore Pathway for CYP2R1
  ""  Vitamin D2 (ergocalciferol) metabolism

"" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP2R1

2 Interacting proteins for CYP2R1 (ENSP000003345923) via UniProtKB, MINT, and/or STRING ""
InteractantInteraction Details
GeneCardExternal ID(s)
GCENSP000002739513STRING: ENSP00000273951
PORENSP000002653023STRING: ENSP00000265302
About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0042359 vitamin D metabolic process IEA--
GO:0055114 oxidation reduction IEA--
About this table

"" CYP2R1 for ontologies           About GeneDecksing


Drugs & Compounds
for CYP2R1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

  User Feedback
"" CYP2R1 for compounds           About GeneDecksing

"" Enzo Life Sciences drugs & compounds for CYP2R1
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for CYP2R1
7 ""Novoseek chemical compound relationships for CYP2R1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin d 36.56 19 12867411 (5), 15128933 (3), 17607662 (2), 15544953 (2) (see all 11)
vitamin d3 12.81 6 19783860 (2), 17607662 (1), 16824767 (1), 16598763 (1) (see all 5)
25-hydroxyvitamin d 8.41 4 17607662 (1), 16600026 (1), 15128933 (1), 12867411 (1)
calcitriol 1.40 1 16600026 (1)
proline 1.25 1 15128933 (1)
leucine 1.07 1 15128933 (1)
retinoic acid 0.78 1 15987645 (1)
About this table


Transcripts
for CYP2R1 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
About This Section

  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
""Applied Biosystems Silencer® siRNAs:  NM_024514  
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CYP2R1
Origene shRNA RFP (see all 2): CYP2R1
Origene basic RS shRNA (see all 2): CYP2R1

""Sigma-Aldrich siRNA Panels and siRNA for CYP2R1
Sigma-Aldrich shRNA for CYP2R1
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate CYP2R1: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_024514  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2R1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2R1
Origene untagged cDNA clones in CMV expression vector (see all 2): CYP2R1
Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2R1
""SABiosciences RT2 qPCR Primer Assay for CYP2R1: PPH18346A ""

REFSEQ mRNAs for CYP2R1 gene: 

NM_024514.4  

Additional cDNA sequence: 

AK092584.1 AK312019.1 AY323817.1 BC052580.1 BC084557.1 BC104907.1 BC104909.1 BC111070.1 
CR600246.1 

12 DOTS entries:

DT.91750931  DT.100777563  DT.100803965  DT.101964522  DT.99992814  DT.100715289  DT.75102966  DT.97839895 
DT.120680334  DT.86847566  DT.91992241  DT.92062716 

24/97 AceView cDNA sequences (see all 97 ):

AI221745 CR600246 BM724854 BQ706528 BX359739 CK904856 AY323817 AI873300 
CK430531 BX381339 CK904857 AA115449 AI582291 NM_024514 BC003642 AW138676 
AW139576 CB305439 BM977264 AU253802 AI818612 BM823213 AW771485 BM055218 

"" highest scoring ESTs for CYP2R1:

AY323817 AA099882 AI735389 AU253802 AW845355 BC052580 BE155715 BE294597 BG826721 BI548611 

Unigene Cluster for CYP2R1:

Cytochrome P450, family 2, subfamily R, polypeptide 1
Hs.371427  [show with all ESTs]
Unigene Representative Sequence: AK092584


GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2R1 (see all 8 )

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1:        -     -     -     -     -     -     -     -     -     -                                                         
SP2:                                      -     -     -     -     -                                                         
SP3:                                                                                      -     -     -                     
SP4:                                            -           -     -                                                         
SP5:                                -     -     -     -     -     -                                                         

About this scheme

ECgene alternative splicing isoforms for CYP2R1

1 Ensembl transcript including schematic representation:
ENST00000334636  

Expression
for CYP2R1 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
About This Section

  User Feedback

CYP2R1 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for CYP2R1

1""  / 2""  / 3""

3 probe-sets matching CYP2R1 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
58365_at2, 3 U95-B 1 0.81 1.00 1.00 1.00 AI735389 0.60 1.00 0.82 1
227109_at2, 3 U133-B 1 0.82 1.00 -- -- AV700558 0.40 1.00 0.76 1
227109_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
About this table

"" CYP2R1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACATTGCAGC

SOURCE GeneReport for Unigene cluster: Hs.371427
Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2R1 ""
""SABiosciences RT2 qPCR Primer Assay for CYP2R1: PPH18346A ""

Orthologs
for CYP2R1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

  User Feedback
Orthologs for CYP2R1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC6129931   -- similar to cytochrome P450, family 2, subfamily R, more 92.66(n)
94.14(a)		 612993  XM_849440.1  XP_854533.1 
chimpanzee
(Pan troglodytes)		 LOC4510421   -- similar to cytochrome P450 2R1 99.47(n)
99.4(a)		 451042  XM_001172230.1  XP_001172230.1 
cow
(Bos taurus)		 CYP2R11   -- cytochrome P450, family 2, subfamily R, polypeptide more 90(n)
90.33(a)		 541302  NM_001076267.1  NP_001069735.1 
rat
(Rattus norvegicus)		 Cyp2r11   -- cytochrome P450, family 2, subfamily r, polypeptide more 88.16(n)
87.82(a)		 361631  XM_341909.2  XP_341910.2 
mouse
(Mus musculus)		 Cyp2r11, 5 75
 cytochrome P450, family 2, subfamily r, polypeptide more1, 5 88.96(n)1
88.62(a)1		 2442091  NM_177382.31  NP_796356.21 
 AK0504535  AY3238185  (see all 8)
About this table        Species with no ortholog for CYP2R1

ENSEMBL Gene Tree for CYP2R1

Paralogs
for CYP2R1 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  User Feedback
Paralogs for CYP2R1 gene
CYP2W12  CYP2C82  CYP2G1P2  CYP2F12  CYP2U12  CYP2J22  CYP2E12  CYP2D62  
CYP2D7P12  CYP2A62  CYP2B62  CYP2C192  CYP2S12  CYP2C92  CYP2C182  CYP2A132  

"" CYP2R1 for paralogs           About GeneDecksing


Genomic Variants
for CYP2R1 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
About This Section

  User Feedback
7 NCBI SNPs in CYP2R1 are shown
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
""
rs20607931,2
C,F,A,H14597753(+) atcccG/Aactca 1 -- ng51 tfbs3""10Minor allele frequency- A:0.35NS EA NA WA 566""
""
rs22917811,2
C,F14581949(+) CGACTA/CGTGCT 1 -- ng31""5Minor allele frequency- C:0.01NS EA 506""
""
rs19931161,2
C,F,A,H14592675(-) TAGCAC/TGCAGG 1 -- int1""17Minor allele frequency- T:0.33NS EA NA WA 1346""
--
rs12684871,2
F14594709(+) tttttG/Atattc 1 -- int1""1Minor allele frequency- A:0.11MN 184""
--
rs12697691,2
--14594699(+) cccggC/Gtaatt 1 -- int1""0--------
--
rs12654671,2
--14594680(+) acaggG/Tgcccg 1 -- int1""0--------
--
rs12697701,2
--14594740(+) caccgG/Tgttag 1 -- int1""0--------
About this table
The following additional 44 SNP(s) have been found in Applied Biosystems data source:
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)


"" rs11607383"" rs10500804"" rs12364125"" rs12798338"" rs7129781"" rs10766198"" rs11023370
"" rs7935792"" rs12577735"" rs6486207"" rs12785494"" rs12365707"" rs12364201"" rs12799081
"" rs7949459"" rs11819875"" rs16930609"" rs35572286"" rs11023376"" rs7946722"" rs11023371
"" rs10832313"" rs35586325"" rs16930625"" rs1553006"" rs1562902"" rs11023377"" rs12794714
"" rs3758762"" rs7936142"" rs12295371"" rs10741657"" rs61495246"" rs11023374"" rs12796659
"" rs11023368"" rs1247720"" rs11602384"" rs10766197"" rs1868997"" rs1270458"" rs11820826
"" rs10766196"" rs1247719

HapMap Linkage Disequilibrium images for CYP2R1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
      Database of Genomic Variants (DGV) variations for CYP2R1: --

Disorders & Mutations
for CYP2R1 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  User Feedback
"" CYP2R1 for disorders           About GeneDecksing

OMIM: 608713   disorders: 600081  

UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0

  • Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency (25HOD3D)[MIM:600081]; also known as
    • pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at
    a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low
    phosphate concentrations, elevated alkaline phosphatase activity, and low levels of 25-hydroxyvitamin D

    10 ""Novoseek disease relationships for CYP2R1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes mellitus insulin-dependent 7.76 6 17607662 (3), 17223345 (2), 19783860 (1)
    vitamin d deficiencies 2.02 1 18476984 (1)
    rickets 1.84 1 15544953 (1)
    atopy 1.61 1 19852851 (1)
    diabetes mellitus (gestational) 1.50 1 18476984 (1)
    diabetic nephropathies 1.40 1 19783860 (1)
    chronic hepatitis c 1.39 1 20162613 (1)
    genetic disorder 1.33 1 15128933 (1)
    asthma 1.03 2 19852851 (1), 16600026 (1)
    ms 0.71 1 20007432 (1)
    About this table

    Locus Specific Mutation Databases: CYP2R1
    Human Gene Mutation Database: CYP2R1
    Human Genome Epidemiology Navigator: CYP2R1 (7 documents)

    Medical News
    for CYP2R1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      User Feedback    		   --

    Publications
    for CYP2R1 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/22 PubMed articles for CYP2R1 gene (see all 22 ):

    Search for CYP2R1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

      User Feedback
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYP2R1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

      User Feedback
    Entrez Gene: 120227 HGNC: 20580 AceView: CYP2R1 Ensembl:ENSG00000186104 euGenes: HUgn120227
    ECgene: CYP2R1 H-InvDB: CYP2R1

    Other Databases showing CYP2R1 gene

    (According to HUGE)
    About This Section

      User Feedback    		   --

    Specialized Databases showing CYP2R1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      User Feedback    		   --

    Intellectual Property
    for CYP2R1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section

      User Feedback    		Patent Information for CYP2R1 gene: ""
    Search GeneIP for patents involving CYP2R1

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for CYP2R1 gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section

      User Feedback    		""
    ""
    Products for CYP2R1:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
    		 "" Free SNP selection tool

    ""
    "" Millipore Custom Antibody & Bulk Services
    "" Millipore Preclinical / Clinical Development Services
    "" Millipore Immunoassay Services
    "" Millipore Target Screening & Profiling Services

    ""
    "" Predesigned and custom siRNAs for CYP2R1"" Antibodies for CYP2R1
    "" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
    "" Lentivirus-delivered shRNAs for CYP2R1"" Browse small molecules at Sigma-Aldrich
    "" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
    "" Antibodies  "" Primer Pairs  
    "" Cell Culture Products  "" ELISAs  
    "" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
    "" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (CYP2R1)
    "" Antibodies (CYP2R1)
    "" Search for Chimera RNAi
    "" Custom Service for Mouse Mab
    "" Custom Service for Rabbit Pab from Full-length Protein


    """"""""
    "" Search for Antibodies & Assays

    "" Tagged/untagged cDNA clones
    "" Validated SYBR primer pairs
    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Search Tocris compounds for CYP2R1
    "" Regulatory tfbs in CYP2R1 upstream (promoter) region
    "" Search Chromatin IP Primers for CYP2R1
    "" DNA Methylation qPCR Primer Assays for CYP2R1
    "" RT2 qPCR Primer Assay for CYP2R1
    "" GNC Network for CYP2R1
    "" Search for microRNAs that regulate CYP2R1
    """"""""
    "" Assays/Drugs/Proteins for CYP2R1
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for CYP2R1
    "" Proteins for CYP2R1
    "" Lysates for CYP2R1
    "" Browse antibodies at Epitomics
    "" Browse Sino Biological Proteins and Antibodies
    "" Browse Sino Biological cDNA Clones
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
    "" Bulk Purchasing
      User Feedback        

    GeneCards Homepage - Last full update: 20 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

    View Random Gene

    Category
    acyl-CoA synthetase family member 3
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
    CYP2R1 gene at Home site.
    hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4