CYP2R1 Gene
protein-coding GIFtS: 61
GCID: GC11M014856
|
|
cytochrome P450, family 2, subfamily R, polypeptide 1
| |
Aliases
for CYP2R1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 2, Subfamily R, Polypeptide 11 2 | | Cytochrome P450 2R12 3 | | Cytochrome P450, Family 2, R12 | | Vitamin D 25-Hydroxylase2 | | EC 1.14.13.1593 |
Export aliases for CYP2R1 gene to outside databasesPrevious GC identifers: GC11M014938 GC11M014863 GC11M014876 GC11M014581 |
Summaries
for CYP2R1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP2R1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for thevitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0Function: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3)
Gene Wiki entry for CYP2R1
|
Genomic Views
for CYP2R1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP2R1 gene promoter:
NF-1 Pbx1a RelA POU6F1 (c2) HNF-3beta FOXO3b HNF-1A AREB6 S8 HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP2R1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2R1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.2 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p15.2CYP2R1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M014856: view genomic region
(about GC identifiers)
Start:
|
14,899,553 bp from pter |
End:
|
14,913,798 bp from pter |
Size:
|
14,246 bases |
Orientation:
|
minus strand |
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Proteins
for CYP2R1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0 (See
protein sequence)Recommended Name: Vitamin D 25-hydroxylase Size: 501 amino acids; 57359 Da
Cofactor: Heme group (By similarity)
Subunit: Homodimer
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheralmembrane protein
3 PDB 3D structures from  and Proteopedia  for CYP2R1:3C6G (3D)
3CZH (3D)
3DL9 (3D)
Secondary accessions: Q2M3H3 Q5RT65Explore the universe of human proteins at neXtProt for CYP2R1: NX_Q6VVX0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6VVX0
CYP2R1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078790.2
ENSEMBL proteins: ENSP00000465097 ENSP00000466060 ENSP00000432087 ENSP00000466604 ENSP00000435484 ENSP00000334592 Reactome Protein details: Q6VVX0
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0005792 | microsome |
-- | -- |
CYP2R1 for ontologies About GeneDecksing
CYP2R1 Antibody Products:
Assay Products for CYP2R1: |
Protein
Domains /
Families
for CYP2R1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP2R1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6VVX0ProtoNet protein and cluster: Q6VVX0 1 Blocks protein family: IPB002401 E-class P450 group I signature
UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0Similarity: Belongs to the cytochrome P450 family |
Function
for CYP2R1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0Function: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3)Catalytic activity: Calciol + O(2) + NADPH = calcidiol + NADP(+) H(2)OBiophysicochemical properties: Kinetic parameters: KM=0.67 uM for vitamin D(2); KM=0.45 uM for vitamin D(3);Enzyme Number (IUBMB): EC 1.14.13.1591
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2R1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP2R1 (NM_024514) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP2R1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2R1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2R1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004497 | monooxygenase activity |
IEA | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
IEA | -- | | GO:0020037 | heme binding |
IEA | -- |
CYP2R1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYP2R1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Vitamin D2 (ergocalciferol) metabolism | | | 2 | Cytochrome P450 - arranged by substrate type | | | 3 | Vitamin D (calciferol) metabolism | | | 4 | Metabolism | | | 5 | Biological oxidations | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CYP2R1
1  GeneGo (Thomson Reuters) Pathway for CYP2R1
3  BioSystems Pathways for CYP2R1
5/9 
Reactome Pathways for CYP2R1 (see all 9)
2 
Kegg Pathways (Kegg details for CYP2R1):
CYP2R1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP2R1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CYP2R1 (ENSP000003345924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
CYP2R1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP2R1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP2R1 for compounds About GeneDecksing
 Browse Tocris compounds for CYP2R1
6 HMDB Compounds for CYP2R1 About this table
2 DrugBank Compounds for CYP2R1 About this table
2 Novoseek chemical compound relationships for CYP2R1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CYP2R1 / CP2R1
|
Transcripts
for CYP2R1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP2R1 gene: NM_024514.4 Unigene Cluster for CYP2R1: Cytochrome P450, family 2, subfamily R, polypeptide 1 Hs.371427 [show with all ESTs]Unigene Representative Sequence: AK09258410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532805(uc001mls.1) ENST00000530609(uc001mlp.3) ENST00000534686(uc001mlq.3)
ENST00000525015 ENST00000532378 ENST00000334636(uc001mlr.3) ENST00000526489
ENST00000526276 ENST00000532641 ENST00000529043
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2R1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2R1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP2R1 (NM_024514) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP2R1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2R1 |
Additional cDNA sequence: AK092584.1 AK312019.1 AY323817.1 BC052580.1 BC084557.1 BC104907.1 BC104909.1 BC111070.1 12 DOTS entries: DT.91750931 DT.100777563 DT.100803965 DT.101964522 DT.99992814 DT.75102966 DT.100715289 DT.97839895 DT.120680334 DT.86847566 DT.91992241 DT.92062716 24/97 AceView cDNA sequences (see all 97): AW139576 CK904857 CR600246 AW138676 AA115449 BQ706528 BX359739 AY323817 CK430531 AI582291 AI873300 BC003642 CK904856 NM_024514 CB305439 AI221745 BM724854 BX381339 AI735389 BM818896 AW771485 BE294597 AI742255 BE217836
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2R1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYP2R1
|
Expression
for CYP2R1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP2R1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATTGCAGC
About this image
See CYP2R1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2R1
SOURCE GeneReport for Unigene cluster: Hs.371427
SABiosciences Expression via Pathway-Focused PCR Array including CYP2R1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP2R1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2R1 |
Orthologs
for CYP2R1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CYP2R1 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for CYP2R1 (if available)
TreeFam Gene Tree for CYP2R1 (if available) |
Paralogs
for CYP2R1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP2R1 gene
- CYP2W12 CYP2C82 CYP2F12 CYP2A72 CYP2U12 CYP2J22 CYP2E12 CYP2D62
- CYP2B7P12 CYP2A62 CYP2B62 CYP2C192 CYP2S12 CYP2C92 CYP2C182 CYP2A132
18/32 SIMAP similar genes for CYP2R1 using alignment to 4 protein entries: CP2R1_HUMAN (see all proteins)
(see all similar genes):CYP2J2 CYP2G1P CYP2U1 CYP2A13 CYP2C8 CYP 2C
CYP2A7 CYP2D6 CYP2C9 CYP2D7P1 CYP2E1 CYP2A6
CYP2B7 CYP2S1 CYP2W1 CYP2F1 CYP2A6V2 CYP2C19
CYP2R1 for paralogs About GeneDecksing
|
Genomic Variants
for CYP2R1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP2R1 (14899553 - 14913798 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP2R1: --
Human Gene Mutation Database (HGMD): CYP2R1
Locus Specific Mutation Databases (LSDB): CYP2R1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2R1 |
|
Disorders
/ Diseases
for CYP2R1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP2R1 for disorders About GeneDecksing
OMIM gene information: 608713
OMIM disorders: 600081
UniProtKB/Swiss-Prot: CP2R1_HUMAN, Q6VVX0
Defects in CYP2R1 are the cause of rickets vitamin D-dependent type 1B (VDDR1B) [MIM:600081]; also known aspseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. A disorder caused by a selective deficiency ofthe active form of vitamin D (1,25-dihydroxyvitamin D3) and resulting in defective bone mineralization and clinicalfeatures of rickets. The patients sera have low calcium concentrations, low phosphate concentrations, elevatedalkaline phosphatase activityand low levels of 25-hydroxyvitamin D
9  diseases for CYP2R1: About MalaCardsrickets due to defect in vitamin d 25-hydroxylation cholesterol rickets gestational diabetes
diabetes mellitus multiple sclerosis nephropathy rabies
asthma
1 disease from the University of Copenhagen DISEASES database for CYP2R1:Rickets Human Genome Epidemiology (HuGE) Navigator: CYP2R1 (11 documents)
Export disorders for CYP2R1 gene to outside databases
|
Publications
for CYP2R1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP2R1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with CYP2R1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25- hydroxylase. (PubMed id 12867411)1, 2, 3 Cheng J.B.... Russell D.W. (2003)
- CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. (PubMed id 17607662)1, 7, 9 Ramos-Lopez E....Badenhoop K. (2007)
- Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25- hydroxylase. (PubMed id 15128933)1, 2, 9 Cheng J.B.... Russell D.W. (2004)
- Cytochromes P450 are essential players in the vitamin D signaling system. (PubMed id 20619365)1, 7 Schuster I. (2011)
- Structural analysis of CYP2R1 in complex with vitamin D3. (PubMed id 18511070)1, 2 Strushkevich N....Park H.W. (2008)
- CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. (PubMed id 17223345)1, 7 Ramos-Lopez E....Badenhoop K. (2007)
- Metabolism of vitamin D by human microsomal CYP2R1. (PubMed id 15465040)1, 2 Shinkyo R.... Inouye K. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution. (PubMed id 12464240)1, 3 Nelson D.R. (2003)
- The GC, CYP2R1 and DHCR7 genes are associated with vit amin D levels in northeastern Han Chinese children. (PubMed id 22801813)1 Zhang Y....Ren L. (2012)
|
External Searches for CYP2R1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP2R1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP2R1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP2R1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP2R1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYP2R1 gene:
Search GeneIP for patents involving CYP2R1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP2R1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP2R1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP2R1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP2R1 | | | OriGene Protein Over-expression Lysate for CYP2R1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP2R1 | | OriGene 3'-UTR Clone for CYP2R1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2R1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2R1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CYP2R1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP2R1 | | OriGene Custom Protein Services for CYP2R1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP2R1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2R1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2R1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2R1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2R1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2R1 |
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| | | | Search Tocris compounds for CYP2R1 |
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 | | | CYP2R1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2R1 |
|  |  |  | | | | ThermoFisher Antibodies for CYP2R1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2R1 |
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