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CYP2J2 Gene

protein-coding   GIFtS: 64

GC01M060284
cytochrome P450, family 2, subfamily J, polypeptide 2
(Previous names: cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for CYP2J2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
cytochrome P450, family 2, subfamily J, polypeptide 21 2     cytochrome P450 2J22
cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 21 2     microsomal monooxygenase2
Arachidonic acid epoxygenase2 3     flavoprotein-linked monooxygenase2
CYPIIJ22 3     EC 1.14.14.13
CPJ22     

External Ids:    HGNC: 26341   Entrez Gene: 15732   Ensembl: ENSG000001347167   UniProtKB: P515893   

Search outside databases for aliases for CYP2J2 gene

Previous GC identifers: GC01M059282 GC01M059716 GC01M059728 GC01M060071

Summaries
for CYP2J2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for CYP2J2:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme
responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. (provided by RefSeq)

UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
Function: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four
regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of
endogenous cardiac arachidonic acid pools

Gene Wiki entry for CYP2J2

Genomic Views
for CYP2J2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CYP2J2 gene upstream (promoter) region "":
AP-1   c-Jun   c-Fos   NF-kappaB   NF-kappaB1   SRY   RelA   YY1   ATF-2   Sp1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP2J2:  ""
MePH01107-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3-p31.2   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p31.3-p31.2

CYP2J2 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M060284:  view genomic region     (about GC identifiers)

Start:
 60,358,980 bp from pter
End:
 60,392,462 bp from pter
Size:
 33,483 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

Proteins
for CYP2J2 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589 (See protein sequence)
Recommended Name: Cytochrome P450 2J2  
Size: 502 amino acids; 57611 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_000766.2  

    ENSEMBL proteins: 
    ENSP00000360247 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for CYP2J2
    ""HuPro® and/or Recombinant Proteins from Abnova for CYP2J2 ""
    "" Origene Purified Recombinant Human Protein: CYP2J2
    ""Novus Biologicals Protein for CYP2J2  ""
    Novus Biologicals Lysates for CYP2J2
    ""Browse Sino Biological Recombinant Proteins  ""

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005792 microsome IDA11901223
    GO:0016020 membrane IEA--
    GO:0019898 extrinsic to membrane ----
    About this table

    "" CYP2J2 for ontologies           About GeneDecksing



    Antibodies for CYP2J2: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for CYP2J2
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (CYP2J2)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for CYP2J2
    ""Browse antibodies at Epitomics

    Assays for CYP2J2: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for CYP2J2

    Protein Domains/
    Families
    for CYP2J2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    "" CYP2J2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR008071 Cyt_P450_E_grp-I_CYP2J-like
     IPR017973 Cyt_P450_C
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P51589

    ProtoNet protein and cluster: P51589

    2 Blocks protein families:
    IPB002401 E-class P450 group I signature
    IPB008071 CYP2J P450 family signature


    UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
    Similarity: Belongs to the cytochrome P450 family

    Gene Function
    for CYP2J2 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

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    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (CYP2J2)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: CYP2J2
    Origene shRNA RFP: CYP2J2
    Origene basic RS shRNA: CYP2J2

    ""Applied Biosystems Silencer® siRNAs for CYP2J2
    ""Sigma-Aldrich siRNA Panels and siRNA for CYP2J2
    Sigma-Aldrich shRNA for CYP2J2
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector: CYP2J2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2J2
    Origene untagged cDNA clones in CMV expression vector: CYP2J2
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
    Function: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four
    regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of
    endogenous cardiac arachidonic acid pools
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Enzyme Number (IUBMB): EC 1.14.14.1 

    Genatlas biochemistry entry for CYP2J2:
    cytochrome p450,subfamily 2J catalyzing the NADPH-dependent oxidation of arachidonic acid to form eicosanoids,highly
    expressed in heart,airway,pancreatic islet cells,intestinal vascular endothelium,involved in the bioactivation of
    fatty acids

    5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497 monooxygenase activity ----
    GO:0005506 iron ion binding ----
    GO:0008392 arachidonic acid epoxygenase activity IDA11901223
    GO:0008404 arachidonic acid 14,15-epoxygenase activity IDA11901223
    GO:0008405 arachidonic acid 11,12-epoxygenase activity IDA11901223
    About this table

    "" CYP2J2 for ontologies           About GeneDecksing

    Pathways & Interactions
    for CYP2J2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

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    "" CYP2J2 for pathways           About GeneDecksing

    1 "" Millipore Pathway for CYP2J2
      ""  HETE and HPETE biosynthesis and metabolism

    5 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  CYP2J2  (Your Favorite Gene powered by Ingenuity)
      ""  Tryptophan Metabolism
    Linoleic Acid Metabolism
    Metabolism of Xenobiotics by Cytochrome P450
    Fatty Acid Metabolism
    Arachidonic Acid Metabolism

    3 "" Kegg Pathways  (Kegg details for CYP2J2):
      ""  hsa00590 Arachidonic acid metabolism
    hsa00591 Linoleic acid metabolism
    hsa01100 Metabolic pathways

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP2J2

    5/37 Interacting proteins for CYP2J2 (ENSP000003602473) via UniProtKB, MINT, and/or STRING (see all 37 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP4F2ENSP000000119893STRING: ENSP00000221700 STRING: ENSP00000011989
    ALOX12ENSP000002515353STRING: ENSP00000251535
    ALOX15ENSP000002937613STRING: ENSP00000293761
    ALOX5ENSP000003635123STRING: ENSP00000363512
    CYP2U1ENSP000003332123STRING: ENSP00000333212
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631 fatty acid metabolic process ----
    GO:0006690 icosanoid metabolic process TAS8631948
    GO:0006805 xenobiotic metabolic process TAS11901223
    GO:0008016 regulation of heart contraction TAS8631948
    GO:0019373 epoxygenase P450 pathway IDA11901223
    About this table

    "" CYP2J2 for ontologies           About GeneDecksing


    Drugs & Compounds
    for CYP2J2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

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    "" CYP2J2 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for CYP2J2
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for CYP2J2
    10/48 ""Novoseek chemical compound relationships for CYP2J2 gene (see all 48 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 93.89 71 8631948 (3), 2358445 (3), 9187259 (2), 9048644 (2) (see all 57)
    ebastine 21.44 9 16896065 (4), 15861034 (2), 16997912 (1), 14622984 (1) (see all 5)
    astemizole 13.69 7 12386130 (5), 15861034 (2)
    carebastine 8.13 3 16896065 (3)
    epoxide 4.63 4 18216721 (2), 8651708 (1), 10828211 (1)
    clotrimazole 4.21 3 3128168 (1), 14622984 (1), 11566953 (1)
    12-hydroxylaurate 3.56 1 9730827 (1)
    11,12-epoxyeicosatrienoic acid 2.65 1 16839864 (1)
    terfenadine 2.62 2 19289568 (2)
    apixaban 2.45 1 19940026 (1)
    About this table


    Transcripts
    for CYP2J2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (CYP2J2)
    ""Applied Biosystems Silencer® siRNAs:  NM_000775  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: CYP2J2
    Origene shRNA RFP: CYP2J2
    Origene basic RS shRNA: CYP2J2

    ""Sigma-Aldrich siRNA Panels and siRNA for CYP2J2
    Sigma-Aldrich shRNA for CYP2J2
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""Search SABiosciences for microRNAs that regulate CYP2J2: ""
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_000775  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2J2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2J2
    Origene untagged cDNA clones in CMV expression vector: CYP2J2
    Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2J2
    ""SABiosciences RT2 qPCR Primer Assay for CYP2J2: PPH01230A ""

    REFSEQ mRNAs for CYP2J2 gene: 

    NM_000775.2  

    Additional cDNA sequence: 

    AB080265.1 AF144566.1 AK055088.1 AK315387.1 BC032594.1 CR596384.1 CR600649.1 CR614246.1 
    CR614399.1 CR623325.1 U37143.2 

    9 DOTS entries:

    DT.453753  DT.101978831  DT.100773481  DT.100773483  DT.121406896  DT.92432080  DT.92432077  DT.100838826 
    DT.95376265 

    24/123 AceView cDNA sequences (see all 123 ):

    AL554497 BX366118 AI818696 CR614246 AJ706696 AA010263 CR623325 BI488558 
    CB161875 BM980074 NM_000775 U37143 CB157402 CR614399 BM452945 C21001 
    AL543751 AL047430 CD013973 AA377317 CD013972 CR600649 BU622942 AI818701 

    "" highest scoring ESTs for CYP2J2:

    U37143 AI263293 H09425 AA010480 AB080265 AF144566 AL047430 AU134771 AV696966 BC032594 

    Unigene Cluster for CYP2J2:

    Cytochrome P450, family 2, subfamily J, polypeptide 2
    Hs.152096  [show with all ESTs]
    Unigene Representative Sequence: AK055088


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2J2 (see all 7 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -     -     -           -                                                                     
    SP2:                    -     -     -           -                                               -                     
    SP3:                                                                                                                  
    SP4:                    -     -     -           -                                         -     -                     
    SP5:                          -     -           -                                                                     

    About this scheme

    ECgene alternative splicing isoforms for CYP2J2

    5 Ensembl transcripts including schematic representations:
    ENST00000371204  ENST00000492633  ENST00000466095  ENST00000468257  ENST00000469406  

    Expression
    for CYP2J2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

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    CYP2J2 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for CYP2J2

    1""  / 2""  / 3""

    4 probe-sets matching CYP2J2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    501_g_at2, 3 U95-A 1 0.81 1.00 0.99 1.16 U37143 1.00 0.90 0.95 1
    500_at2, 3 U95-A 1 0.75 1.00 0.99 0.85 U37143 1.00 0.90 0.95 1
    205073_at2, 3 U133-A 1 0.64 1.00 -- -- NM_000775 0.60 1.00 0.82 1
    205073_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    "" CYP2J2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCACGTGTTC

    SOURCE GeneReport for Unigene cluster: Hs.152096

    Expression variation in blood from EXPOLDB for CYP2J2

    UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
    Tissue specificity: Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney

    Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2J2 ""
    ""SABiosciences RT2 qPCR Primer Assay for CYP2J2: PPH01230A ""

    Orthologs
    for CYP2J2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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    Orthologs for CYP2J2 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC6101951   -- similar to cytochrome P450, family 2, subfamily J, more 84.36(n)
    79.44(a)    		 610195  XM_847632.1  XP_852725.1 
    chimpanzee
    (Pan troglodytes)    		 LOC4568961   -- similar to cytochrome P450 monooxygenase CYP2J2 99.4(n)
    98.8(a)    		 456896  XM_513445.2  XP_513445.2 
    cow
    (Bos taurus)    		 LOC5309291   -- hypothetical LOC530929 82.44(n)
    80.04(a)    		 530929  XM_609410.3  XP_609410.3 
    rat
    (Rattus norvegicus)    		 Cyp2j41   -- cytochrome P450, family 2, subfamily J, polypeptide more 79.93(n)
    76.2(a)    		 65210  NM_023025.2  NP_075414.2 
    mouse
    (Mus musculus)    		 Cyp2j61, 5 4 (46.50 cM)5
    		 cytochrome P450, family 2, subfamily j, polypeptide more1, 5 78.27(n)1
    76.2(a)1    		 131101  NM_010008.31  NP_034138.21 
     AI3239345  AK0336145  (see all 16)
    About this table        Species with no ortholog for CYP2J2

    ENSEMBL Gene Tree for CYP2J2

    Paralogs
    for CYP2J2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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    Paralogs for CYP2J2 gene
    CYP2W12  CYP2C82  CYP2G1P2  CYP2F12  CYP2R12  CYP2U12  CYP2E12  CYP2D62  
    CYP2D7P12  CYP2A62  CYP2B62  CYP2C192  CYP2S12  CYP2C92  CYP2A132  CYP2C182  

    "" CYP2J2 for paralogs           About GeneDecksing


    Genomic Variants
    for CYP2J2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

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    10/40 NCBI SNPs in CYP2J2 are shown (see all 40 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 136)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs22802741,2
    		C,F,O,A60359077(+) AGGAAA/TCATTA 1 -- ut31 ese3""17Minor allele frequency- T:0.14EA NS NA WA 2700""
    ""
    rs22802731,2
    		C,F,A58469962(+) CACTAT/CAGATA 1 -- ng31""21Minor allele frequency- C:0.14EA NS NA WA 2288""
    ""
    rs43887261,2
    		C,F,A60359156(+) CGGACG/AAGACA 1 -- ut31 ese3""15Minor allele frequency- A:0.09NS EA NA WA 1252""
    --
    rs75333591,2
    		C,F,A58504333(+) attttT/Cgtatt 1 -- ng51""1Minor allele frequency- C:0.26NS 106""
    ""
    rs8902931,2
    		C,F58503411(-) GGAGCG/TAGGCG 1 -- ng51""1Minor allele frequency- T:0.10NS 158""
    ""
    rs22281131,2
    		C,F60381612(-) GAAAAA/GTGGTA 2 N S ref1 mis1""26Minor allele frequency- G:0.00MN NS EA NA WA 3856""
    ""
    rs22291901,2
    		C,F60381674(-) ATCCAA/C/G/T 
                ATGGA     		4 Q H mis1 ref1 syn1 ese3""21""MN NS EA WA 3196""
    ""
    rs10565961,2
    		C60370601(-) CCCCCT/AGAACG 2 /Q /L mis1 ref1""4Minor allele frequency- A:0.00NS EA 406""
    ""
    rs22281141,2
    		C,F,H60359335(-) GCTGTT/ACCTCA 2 /V syn1 ref1 ese3""16Minor allele frequency- A:0.00MN NS EA 2358""
    ""
    rs22291911,2
    		C,F60373500(-) CTCTGC/AGATGG 2 /R syn1 ref1 ese3""14Minor allele frequency- A:0.03MN NS EA NA WA 2072""
    About this table

    HapMap Linkage Disequilibrium images for CYP2J2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for CYP2J2: --

    Disorders & Mutations
    for CYP2J2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" CYP2J2 for disorders           About GeneDecksing

    OMIM: 601258

    10/31 ""Novoseek disease relationships for CYP2J2 gene (see all 31 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 4.15 6 18219097 (3), 17286575 (3)
    ischemic stroke 2.56 4 18216721 (3), 18496133 (1)
    coronary; ischemic 2.00 1 19851119 (1)
    asthma intrinsic 1.85 1 17475630 (1)
    hypertension 1.62 11 15864120 (8), 18219097 (1), 17286575 (1), 14575523 (1)
    cad 1.42 8 17429317 (5), 19105833 (1), 16839864 (1), 15466638 (1)
    heart; ischemic 1.35 1 17220242 (1)
    lung metastases 1.22 2 17638876 (2)
    infarction; myocardial 1.16 6 18496133 (5), 19105833 (1)
    inflammatory myofibroblastic tumor 1.05 1 19550113 (1)
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    Locus Specific Mutation Databases: CYP2J2
    Human Gene Mutation Database: CYP2J2
    Genetic Association Database: CYP2J2
    Human Genome Epidemiology Navigator: CYP2J2 (28 documents)

    Medical News
    for CYP2J2 gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for CYP2J2 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/95 PubMed articles for CYP2J2 gene (see all 95 ):

    Search for CYP2J2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CYP2J2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1573 HGNC: 2634 AceView: CYP2J2 Ensembl:ENSG00000134716 euGenes: HUgn1573
    ECgene: CYP2J2 Kegg: 1573 H-InvDB: CYP2J2

    Other Databases showing CYP2J2 gene

    (According to HUGE)
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    Specialized Databases showing CYP2J2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2j2.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp2j2/

    Intellectual Property
    for CYP2J2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for CYP2J2 gene: ""
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