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CYP2J2 Gene

protein-coding   GIFtS: 68
GCID: GC01M060284

Cytochrome P450, Family 2, Subfamily J, Polypeptide 2

(Previous names: cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase)...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily J, Polypeptide 21 2     CPJ22
Cytochrome P450, Subfamily IIJ (Arachidonic Acid Epoxygenase) Polypeptide
21 2
     Cytochrome P450 2J22
Arachidonic Acid Epoxygenase2 3     Flavoprotein-Linked Monooxygenase2
CYPIIJ22 3     Microsomal Monooxygenase2
EC 1.14.14.13 8     

External Ids:    HGNC: 26341   Entrez Gene: 15732   Ensembl: ENSG000001347167   OMIM: 6012585   UniProtKB: P515893   

Export aliases for CYP2J2 gene to outside databases

Previous GC identifers: GC01M059282 GC01M059716 GC01M059728 GC01M060071 GC01M058469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2J2 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme
responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2J2 Gene:
CYP2J2 (cytochrome P450, family 2, subfamily J, polypeptide 2) is a protein-coding gene. Diseases associated with CYP2J2 include fascioliasis, and antley-bixler syndrome. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
Function: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all
four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation
of endogenous cardiac arachidonic acid pools

Gene Wiki entry for CYP2J2 Gene

PharmGKB "VIP" summary for CYP2J2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2J2 gene promoter:
         c-Fos   Sp1   AP-1   ATF-2   RelA   c-Jun   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP2J2 promoter sequence
   Search Chromatin IP Primers for CYP2J2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2J2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3-p31.2   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p31.3-p31.2

CYP2J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2J2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M060284:  view genomic region     (about GC identifiers)

Start:
60,358,980 bp from pter      End:
60,392,462 bp from pter
Size:
33,483 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589 (See protein sequence)
Recommended Name: Cytochrome P450 2J2  
Size: 502 amino acids; 57611 Da
Cofactor: Heme group (By similarity)
Secondary accessions: B2RD33 Q8TF13

Explore the universe of human proteins at neXtProt for CYP2J2: NX_P51589

Explore proteomics data for CYP2J2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2J2 (P51589) (see all 7)
     EERIQEE  PFSIGKR  AGTETTS  EIDRVIG 


    See CYP2J2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000766.2  
    ENSEMBL proteins: 
     ENSP00000360247  
    Reactome Protein details: P51589

    CYP2J2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2J2
    CYP2 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR008071 Cyt_P450_E_grp-I_CYP2J-like
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P51589

    ProtoNet protein and cluster: P51589

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008071 CYP2J P450 family signature


    UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
    Similarity: Belongs to the cytochrome P450 family


    CYP2J2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2J2_HUMAN, P51589
    Function: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all
    four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation
    of endogenous cardiac arachidonic acid pools
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Genatlas biochemistry entry for CYP2J2:
    cytochrome p450,subfamily 2J catalyzing the NADPH-dependent oxidation of arachidonic acid to form
    eicosanoids,highly expressed in heart,airway,pancreatic islet cells,intestinal vascular endothelium,involved in
    the bioactivation of fatty acids

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0008392arachidonic acid epoxygenase activity IDA11901223
    GO:0008404arachidonic acid 14,15-epoxygenase activity IDA11901223
    GO:0008405arachidonic acid 11,12-epoxygenase activity IDA11901223
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
         
    CYP2J2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP2J2
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    miRNA
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    miRTarBase miRNAs that target CYP2J2:
    hsa-let-7b-5p (MIRT006875)

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    1 qRT-PCR Assays for microRNA that regulate CYP2J2:
    hsa-miR-584
    SwitchGear 3'UTR luciferase reporter plasmidCYP2J2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CYP2J2 (NM_000775)
    Sino Biological Human cDNA Clone for CYP2J2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2J2_HUMAN, P51589: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    CYP2J2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2J2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    HETE and HPETE biosynthesis and metabolism0.33
    Arachidonic acid metabolism0.41
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.00
    Arachidonic acid metabolism0.40
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty acids0.00
    cytochrome P4500.74
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    5Tryptophan metabolism
    Tryptophan metabolism0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CYP2J2
        HETE and HPETE biosynthesis and metabolism

    4 BioSystems Pathways for CYP2J2
        cytochrome P450
    Arachidonate Epoxygenase / Epoxide Hydrolase
    metapathway biotransformation
    Tryptophan metabolism


    3 Reactome Pathways for CYP2J2
        Fatty acids
    Xenobiotics
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)


    Selected Kegg Pathways  (Kegg details for CYP2J2) (see all 6):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Metabolic pathways
    Serotonergic synapse
    Inflammatory mediator regulation of TRP channels


    CYP2J2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP2J2: 
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP2J2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2J2 (ENSP000003602474) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX15BENSP000003695304STRING: ENSP00000369530
    ALOX5ENSP000003635124STRING: ENSP00000363512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006690icosanoid metabolic process TAS8631948
    GO:0006805xenobiotic metabolic process TAS11901223
    GO:0008016regulation of heart contraction TAS8631948
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019373epoxygenase P450 pathway TAS--

    CYP2J2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2J2 (CP2J2)

    Selected HMDB Compounds for CYP2J2 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    7 DrugBank Compounds for CYP2J2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholecalciferol(+)-vitamin D3 (see all 5)67-97-0enzymesubstrate20619365 16842832
    Astemizole-- 68844-77-9enzymesubstrate19934256
    MasoprocolDihydronorguaiaretic acid (see all 7)500-38-9enzymeinhibitor19934256
    Rivaroxaban-- 366789-02-8enzymesubstrate20135071
    Terfenadine-- 50679-08-8enzymeinhibitor19934256
    Apixaban-- 503612-47-3enzymesubstrate--
    Levomilnacipran-- 96847-55-1enzymesubstrate--

    7 Novoseek inferred chemical compound relationships for CYP2J2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ebastine 86.7 13 16896065 (4), 12386130 (1), 16997912 (1), 15861034 (1)
    arachidonic acid 79.3 46 11901223 (2), 8631948 (2), 16480681 (2), 18675280 (2) (see all 30)
    astemizole 67.9 7 12386130 (5), 15861034 (1)
    terfenadine 63.8 2 19289568 (2)
    20-hydroxyeicosatetraenoic acid 60 1 16868033 (1)
    anti-histamine 50.2 2 16182271 (1), 12386130 (1)
    epoxide 48.8 3 18216721 (2), 10828211 (1)



    CYP2J2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP2J2 gene: 
    NM_000775.2  

    Unigene Cluster for CYP2J2:

    Cytochrome P450, family 2, subfamily J, polypeptide 2
    Hs.152096  [show with all ESTs]
    Unigene Representative Sequence: AK055088
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371204(uc001czq.3) ENST00000492633 ENST00000466095 ENST00000469406
    ENST00000468257

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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CYP2J2
      QuantiFast Probe-based Assays in human, mouse, rat CYP2J2

    Additional mRNA sequence: 

    AB080265.1 AF144566.1 AK055088.1 AK315387.1 BC032594.1 U37143.2 

    9 DOTS entries:

    DT.453753  DT.101978831  DT.100773481  DT.100773483  DT.121406896  DT.92432080  DT.92432077  DT.100838826 
    DT.95376265 

    Selected AceView cDNA sequences (see all 123):

    CD013973 AA377317 AL554497 BI488558 CR614246 NM_000775 AA010263 U37143 
    C21001 CD013972 AI818701 CR623325 AI818696 CR614399 BM980074 AJ706696 
    CR596384 CB161875 BX089976 CR600649 CB157402 AL543751 AL047430 BU622942 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP2J2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -     -     -           -                                                                     
    SP2:                    -     -     -           -                                               -                     
    SP3:                                                                                                                  
    SP4:                    -     -     -           -                                         -     -                     
    SP5:                          -     -           -                                                                     


    ECgene alternative splicing isoforms for CYP2J2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CYP2J2 expression in normal human tissues (normalized intensities)      CYP2J2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACGTGTTC
    CYP2J2 Expression
    About this image


    CYP2J2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
    CYP2J2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2J2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.152096

    UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589
    Tissue specificity: Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYP2J2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2j61 , 5 cytochrome P450, family 2, subfamily j, polypeptide more1, 5 78.4(n)1
    76.6(a)1
      4 (44.62 cM)5
    131101  NM_010008.41  NP_034138.31 
     965161385 
    chicken
    (Gallus gallus)
    Aves LOC4247291 cytochrome P450 2J2-like 61.08(n)
    55.97(a)
      424729  XM_422553.3  XP_422553.2 
    lizard
    (Anolis carolinensis)
    Reptilia CYP2J26
    cytochrome P450, family 2, subfamily J, polypeptid...
    54(a)
    1 ↔ 1
    4(101402466-101430317)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX707908.12   -- 75.45(n)    BX707908.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.254262 Danio rerio mRNA similar to cytochrome P450 (cDNA clone more 76.18(n)    BC049521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp18a13
    Cyp305a11
    steroid biosynthesis cytochrome P4503
    Cyp305a11
    33(a)
    (best of 5)3
    45.06(n)1
    34.75(a)1
      17D13
    401611  NM_140894.31  NP_649151.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R08F11.33
    cyp-14A31
    cytochrome P4503
    cyp-14A31
    36(a)
    (best of 29)3
    46.7(n)1
    37.42(a)1
      V(3800680-3803258)3
    1871851  NM_077804.11  NP_510205.11 


    ENSEMBL Gene Tree for CYP2J2 (if available)
    TreeFam Gene Tree for CYP2J2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2J2 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  
    CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  CYP2A132  
    Selected SIMAP similar genes for CYP2J2 using alignment to 3 protein entries:     CP2J2_HUMAN (see all proteins) (see all similar genes):
    CYP2R1    CYP2A13    CYP2A6    CYP2B6    CYP2A7    CYP2B
    CYP2B7    CYP2A6V2    CYP2E1    CYP2U1    CYP2F1    CYP2D6
    CYP2C8    CYP 2C    CYP2S1    CYP2C9    CYP2C19    CYP2C18

    CYP2J2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP2J2 (see all 747)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs721804021,2
    C--60361977(+) ATAAA-/ATATATA 1 -- int10--------
    rs346921761,2
    C--60361978(+) ATATATA/-CACAC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs115722971,2
    C,F,H--60369147(-) CTATCC/TGATGT 1 -- int112Minor allele frequency- T:0.02NS EA NA 1382
    rs115722481,2
    C,F--60380332(-) CACAGT/CGCATT 1 -- int12Minor allele frequency- C:0.02NS WA 150
    rs49157841,2
    C,F,H--60380886(+) agaccG/Agtgcc 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1137525971,2
    C,F--60387235(+) TAGGGC/TTATAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs787982231,2
    --60434427(+) GAAACC/TGTTTC 1 -- ds50010--------
    rs115723271,2
    C,F,H--60434661(-) GTGAGA/GTATGT 1 -- ds500117Minor allele frequency- G:0.09NS EA NA WA 2006
    rs22802731,2
    C,F,A,H--60434693(+) CACTAT/CAGATA 1 -- ut3132Minor allele frequency- C:0.16EA NS NA WA CSA 4004
    rs412877221,2
    --60434747(+) TCACCA/TTTTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CYP2J2 (60358980 - 60392462 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CYP2J2: --
    The Human Cytochrome P450 Allele Nomenclature Database: CYP2J2 
    Human Gene Mutation Database (HGMD): CYP2J2
    Locus Specific Mutation Databases (LSDB): CYP2J2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601258    OMIM disorders: --

    Selected diseases for CYP2J2 (see all 29):    About MalaCards
    fascioliasis    antley-bixler syndrome    human immunodeficiency virus infectious disease    toxic encephalopathy
    constipation    aspergillosis    porphyria    coronary artery disease
    candidiasis    brain disease    diarrhea    cholestasis
    hypercholesterolemia    skin disease    essential hypertension    coronary heart disease
    atherosclerosis    labyrinthitis    hypertension    nasopharyngitis

    1 disease from the University of Copenhagen DISEASES database for CYP2J2:
    Hypertension

    CYP2J2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for CYP2J2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiovascular diseases 21.9 1 16182271 (1)
    coronary artery disease 11.2 2 15466638 (1), 16839864 (1)
    carcinoma 4.01 8 15930289 (3), 19550113 (3)
    atherosclerosis 0 2 17429317 (2)
    tumors 0 8 19550113 (3), 15930289 (2), 19289568 (1)
    cancer 0 5 16182271 (1), 19289568 (1), 19851119 (1), 19550113 (1) (see all 5)

    Genetic Association Database (GAD): CYP2J2
    Human Genome Epidemiology (HuGE) Navigator: CYP2J2 (33 documents)

    Export disorders for CYP2J2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2J2 gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with CYP2J2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. (PubMed id 15861034)1, 4, 9 Lee S.S....Shin J.G. (Pharmacogenet. Genomics 2005)
    2. Cloning of CYP2J2 gene and identification of functional polymorphisms. (PubMed id 11901223)1, 2, 9 King L.M.... Zeldin D.C. (Mol. Pharmacol. 2002)
    3. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. (PubMed id 8631948)1, 2, 9 Wu S.... Zeldin D.C. (J. Biol. Chem. 1996)
    4. Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. (PubMed id 12386130)1, 2, 9 Matsumoto S.... Yamazoe Y. (Drug Metab. Dispos. 2002)
    5. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. (PubMed id 15466638)1, 4, 9 Spiecker M....Liao J.K. (Circulation 2004)
    6. Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke. (PubMed id 18496133)1, 4, 9 Marciante K.D....Psaty B.M. (Pharmacogenet. Genomics 2008)
    7. Promoter polymorphism G-50T of a human CYP2J2 epoxygenase gene is associated with common susceptibility to asthma. (PubMed id 17475630)1, 4, 9 Polonikov A.V....Panfilov V.I. (Chest 2007)
    8. The common functional polymorphism -50G&gt;T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes. (PubMed id 19851119)1, 4, 9 Fava C....Melander O. (J. Hypertens. 2010)
    9. CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 17429317)1, 4, 9 Lee C.R....Zeldin D.C. (Pharmacogenet. Genomics 2007)
    10. The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile. (PubMed id 19105833)1, 4, 9 BAPrgel J....Spiecker M. (BMC Cardiovasc Disord 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1573 HGNC: 2634 AceView: CYP2J2 Ensembl:ENSG00000134716 euGenes: HUgn1573
    ECgene: CYP2J2 Kegg: 1573 H-InvDB: CYP2J2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP2J2 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2j2.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp2j2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2J2 gene:
    Search GeneIP for patents involving CYP2J2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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