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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP2J2 Gene

protein-coding GIFtS: 67
GCID: GC01M060284

cytochrome P450, family 2, subfamily J, polypeptide 2

(Previous names: cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase)...)

Explore 32 diseases affiliated with
CYP2J2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily J, Polypeptide 2¹ ²		CPJ2²
Cytochrome P450, Subfamily IIJ (Arachidonic Acid Epoxygenase) Polypeptide 2¹ ²		Cytochrome P450 2J2²
Arachidonic Acid Epoxygenase² ³		Flavoprotein-Linked Monooxygenase²
CYPIIJ2² ³		Microsomal Monooxygenase²
EC 1.14.14.1³ ⁸

External Ids:	HGNC: 2634¹	Entrez Gene: 1573²	Ensembl: ENSG00000134716⁷	OMIM: 601258⁵	UniProtKB: P51589³

Export aliases for CYP2J2 gene to outside databases

Previous GC identifers: GC01M059282 GC01M059716 GC01M059728 GC01M060071 GC01M058469

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2J2:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme

responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589

Function: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four

regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of

endogenous cardiac arachidonic acid pools

Gene Wiki entry for CYP2J2

PharmGKB "VIP" summary for CYP2J2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2J2 gene promoter:
c-Fos Sp1 AP-1 ATF-2 RelA c-Jun YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP2J2 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP2J2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2J2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3-p31.2 Ensembl cytogenetic band: 1p32.1 HGNC cytogenetic band: 1p31.3-p31.2

CYP2J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2J2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M060284: view genomic region (about GC identifiers)

Start:	60,358,980 bp from pter	End:	60,392,462 bp from pter
Size:	33,483 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589 (See protein sequence)

Recommended Name: Cytochrome P450 2J2

Size: 502 amino acids; 57611 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Explore the universe of human proteins at neXtProt for CYP2J2: NX_P51589

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51589

4/7 DME Specific Peptides for CYP2J2 (P51589) (see all 7)

EERIQEE

PFSIGKR

AGTETTS

EIDRVIG

CYP2J2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000766.2

ENSEMBL proteins:

ENSP00000360247

Reactome Protein details: P51589
Human Recombinant Protein Products for CYP2J2:

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	Uscn Proteins for CYP2J2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP2J2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2J2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR008071 Cyt_P450_E_grp-I_CYP2J-like

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P51589

ProtoNet protein and cluster: P51589

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008071 CYP2J P450 family signature

UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP2J2_HUMAN, P51589

Function: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four

regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of

endogenous cardiac arachidonic acid pools

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Genatlas biochemistry entry for CYP2J2:

cytochrome p450,subfamily 2J catalyzing the NADPH-dependent oxidation of arachidonic acid to form eicosanoids,highly

expressed in heart,airway,pancreatic islet cells,intestinal vascular endothelium,involved in the bioactivation of

fatty acids

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0008392	arachidonic acid epoxygenase activity	IDA	11901223
GO:0008404	arachidonic acid 14,15-epoxygenase activity	IDA	11901223
GO:0008405	arachidonic acid 11,12-epoxygenase activity	IDA	11901223
GO:0009055	electron carrier activity	IEA	--

CYP2J2 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2J2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Arachidonic acid metabolism

	Arachidonic acid metabolism	1.00			HETE and HPETE biosynthesis and metabolism	0.39
	Arachidonic acid metabolism	0.42			HETE and HPETE biosynthesis and metabolism	0.39

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

1.00

Arachidonate Epoxygenase / Epoxide Hydrolase

0.36

Biological oxidations

Biological oxidations

1.00

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CYP2J2

HETE and HPETE biosynthesis and metabolism

1 GeneGo (Thomson Reuters) Pathway for CYP2J2

HETE and HPETE biosynthesis and metabolism

4 BioSystems Pathways for CYP2J2

	cytochrome P450
	Arachidonate Epoxygenase / Epoxide Hydrolase
	Tryptophan metabolism
	metapathway biotransformation

5/8 Reactome Pathways for CYP2J2 (see all 8)

	Cytochrome P450 - arranged by substrate type
	Fatty acids
	Metabolism
	Arachidonic acid metabolism
	Biological oxidations

3 Kegg Pathways (Kegg details for CYP2J2):

	Arachidonic acid metabolism
	Linoleic acid metabolism
	Metabolic pathways

CYP2J2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP2J2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for CYP2J2 (ENSP00000360247⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALOX12	ENSP00000251535⁴	STRING: ENSP00000251535
ALOX12B	ENSP00000315167⁴	STRING: ENSP00000315167
ALOX15	ENSP00000293761⁴	STRING: ENSP00000293761
ALOX15B	ENSP00000369530⁴	STRING: ENSP00000369530
ALOX5	ENSP00000363512⁴	STRING: ENSP00000363512

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006690	icosanoid metabolic process	TAS	8631948
GO:0006805	xenobiotic metabolic process	TAS	11901223
GO:0008016	regulation of heart contraction	TAS	8631948
GO:0019373	epoxygenase P450 pathway	IDA	11901223
GO:0043651	linoleic acid metabolic process	IDA	11901223

CYP2J2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP2J2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP2J2

10/49 HMDB Compounds for CYP2J2 (see all 49) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

5 DrugBank Compounds for CYP2J2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cholecalciferol	(+)-vitamin D3 (see all 5)	67-97-0	enzyme	substrate	20619365 16842832
Astemizole	--	68844-77-9	enzyme	substrate	19934256
Masoprocol	Dihydronorguaiaretic acid (see all 7)	500-38-9	enzyme	inhibitor	19934256
Rivaroxaban	--	366789-02-8	enzyme	substrate	20135071
Terfenadine	--	50679-08-8	enzyme	inhibitor	19934256

7 Novoseek chemical compound relationships for CYP2J2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ebastine	86.7	13	16896065 (4), 12386130 (1), 16997912 (1), 15861034 (1)
arachidonic acid	79.3	46	11901223 (2), 8631948 (2), 16480681 (2), 18675280 (2) (see all 30)
astemizole	67.9	7	12386130 (5), 15861034 (1)
terfenadine	63.8	2	19289568 (2)
20-hydroxyeicosatetraenoic acid	60	1	16868033 (1)
anti-histamine	50.2	2	16182271 (1), 12386130 (1)
epoxide	48.8	3	18216721 (2), 10828211 (1)

Search CenterWatch for drugs/clinical trials and news about CYP2J2 / CP2J2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP2J2 gene:

NM_000775.2

Unigene Cluster for CYP2J2:

Cytochrome P450, family 2, subfamily J, polypeptide 2

Hs.152096 [show with all ESTs]

Unigene Representative Sequence: AK055088

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371204(uc001czq.3) ENST00000492633 ENST00000466095 ENST00000469406

ENST00000468257

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Additional cDNA sequence:

AB080265.1 AF144566.1 AK055088.1 AK315387.1 BC032594.1 U37143.2

9 DOTS entries:

DT.453753 DT.101978831 DT.100773481 DT.100773483 DT.121406896 DT.92432080 DT.92432077 DT.100838826

DT.95376265

24/123 AceView cDNA sequences (see all 123):

AJ706696 CB157402 AA010263 BM452945 CR614399 AL543751 C21001 AA377317

AL047430 CD013973 CD013972 NM_000775 BI488558 AI818701 BU622942 CR600649

BX089976 CR623325 CR614246 AL554497 CR596384 BM980074 BX366118 U37143

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2J2 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:							-		-		-				-
SP2:							-		-		-				-																-
SP3:
SP4:							-		-		-				-														-		-
SP5:									-		-				-

ECgene alternative splicing isoforms for CYP2J2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2J2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACGTGTTC

About this image

CYP2J2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

See CYP2J2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2J2

SOURCE GeneReport for Unigene cluster: Hs.152096

UniProtKB/Swiss-Prot: CP2J2_HUMAN, P51589

Tissue specificity: Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney

SABiosciences Expression via Pathway-Focused PCR Array including CYP2J2:

Drug Metabolism in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP2J2 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC424729¹	cytochrome P450 2J2-like	61.2(n) 56.09(a)		424729 XM_422553.2 XP_422553.2
lizard (Anolis carolinensis)	Reptilia	CYP2J2⁶	--	58(a)	1 ↔ 1	4(101409935-101430317)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX707908.1²	--	75.45(n)		BX707908.1
zebrafish (Danio rerio)	Actinopterygii	Dr.25426²	Danio rerio mRNA similar to cytochrome P450 (cDNA clone more	76.18(n)		BC049521.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp18a1³ Cyp305a1¹	steroid biosynthesis cytochrome P450³ CG8733-PA¹	33(a) (best of 5)³ 45.3(n)¹ 35.04(a)¹		17D1³ 40161¹ NM_140894.2¹ NP_649151.1¹
worm (Caenorhabditis elegans)	Secernentea	R08F11.3³	cytochrome P450	36(a) (best of 29)		V(3800680-3803258) --
thale cress (Arabidopsis thaliana)	eudicotyledons	FAH1¹	ferulic acid 5-hydroxylase 1	42.13(n) 29.94(a)		829779 NM_119790.2 NP_195345.1

ENSEMBL Gene Tree for CYP2J2 (if available)
TreeFam Gene Tree for CYP2J2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2J2 gene

CYP2W1² CYP2C8² CYP2F1² CYP2A7² CYP2R1² CYP2U1² CYP2E1² CYP2D6²

CYP2B7P1² CYP2A6² CYP2B6² CYP2C19² CYP2S1² CYP2C9² CYP2A13² CYP2C18²

18/30 SIMAP similar genes for CYP2J2 using alignment to 4 protein entries: CP2J2_HUMAN (see all proteins) (see all similar genes):

CYP2R1 CYP2A13 CYP2A6 CYP2B CYP2B6 CYP2G1P

CYP2A7 CYP2B7 CYP2A6V2 CYP2U1 CYP2D6 CYP2E1

CYP2F1 CYP2C8 CYP 2C CYP2C9 CYP2S1 CYP2W1

CYP2J2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78798223^1,2		--	58469696(+)	`GAAACC/TGTTTC`	1	--	ds500¹		0	--	--	--	--
rs41287722^1,2		--	58470016(+)	`TCACCA/TTTTCT`	1	--	ut3¹		0	--	--	--	--
rs77511546^1,2	F	--	58471156(+)	`TCCCTG/ATTATG`	1	--	int¹		1		WA	118
rs77403553^1,2		--	58472184(+)	`CTTTTT/GCTCTG`	1	--	int¹		2		CSA WA	120
rs11572324^1,2	C,F,H	--	58472773(-)	`TTTGGA/GAAAAA`	1	--	int¹		14		NS EA NA WA	1396
rs12038104^1,2	C,F,H	--	58473051(+)	`TTCACA/C/TTATTG`	1	--	int¹		7		NS EA NA	702
rs11572323^1,2	C	--	58473165(-)	`ATAAGT/GAAATA`	1	--	int¹		1		NS	118
rs11572322^1,2	C,F	--	58473292(-)	`TCACAT/CAGGGG`	1	--	int¹		2		NS WA	126
rs72925823^1,2	C	--	58473704(+)	`TATGCG/AAAAAT`	1	--	int¹		1		WA	2
rs11572319^1,2	C	--	58474645(-)	`AAATGG/CATCAG`	1	--	int¹		1		NS	138

HapMap Linkage Disequilibrium report for CYP2J2 (60358980 - 60392462 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP2J2: --
Human Gene Mutation Database (HGMD): CYP2J2

Locus Specific Mutation Databases (LSDB): CYP2J2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2J2

DNA2.0 Custom Variant and Variant Library Synthesis for CYP2J2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP2J2 for disorders           About GeneDecksing

OMIM gene information: 601258    OMIM disorders: --

20/32 diseases for CYP2J2 (see all 32):    About MalaCards

antley-bixler syndrome human immunodeficiency virus infectious disease cholesterol toxic encephalopathy

coronary heart disease fascioliasis essential hypertension myocardial infarction

porphyria aspergillosis constipation diabetes mellitus

candidiasis atherosclerosis neurodegenerative disease skin disease

cholestasis brain disease hypercholesterolemia kidney disease

1 disease from the University of Copenhagen DISEASES database for CYP2J2:

Hypertension

6 Novoseek disease relationships for CYP2J2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cardiovascular diseases	21.9	1	16182271 (1)
coronary artery disease	11.2	2	15466638 (1), 16839864 (1)
carcinoma	4.01	8	15930289 (3), 19550113 (3)
atherosclerosis	0	2	17429317 (2)
tumors	0	8	19550113 (3), 15930289 (2), 19289568 (1)
cancer	0	5	16182271 (1), 19289568 (1), 19851119 (1), 19550113 (1) (see all 5)

Genetic Association Database (GAD): CYP2J2
Human Genome Epidemiology (HuGE) Navigator: CYP2J2 (33 documents)

Export disorders for CYP2J2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP2J2 gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with CYP2J2)

Utopia: connect your pdf to the dynamic
world of online information

Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. (PubMed id 15861034)^{1, 4, 9} Lee S.S....Shin J.G. (2005)
Cloning of CYP2J2 gene and identification of functional polymorphisms. (PubMed id 11901223)^{1, 2, 9} King L.M.... Zeldin D.C. (2002)
Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. (PubMed id 8631948)^{1, 2, 9} Wu S.... Zeldin D.C. (1996)
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. (PubMed id 15466638)^{1, 4, 9} Spiecker M....Liao J.K. (2004)
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. (PubMed id 15864120)^{1, 4, 9} King L.M....Zeldin D.C. (2005)
CYP2J2*7 single nucleotide polymorphism in a Chinese population. (PubMed id 16182271)^{1, 4, 9} Wang H....He F. (2006)
Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus. (PubMed id 14575523)^{1, 4, 9} Pucci L....Longo V. (2003)
Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. (PubMed id 9570962)^{1, 3, 9} Ma J....Zeldin D.C. (1998)
The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension. (PubMed id 16202848)^{1, 4} Dreisbach A.W....Lertora J.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1573	HGNC: 2634	AceView: CYP2J2	Ensembl:ENSG00000134716	euGenes: HUgn1573
ECgene: CYP2J2	Kegg: 1573	H-InvDB: CYP2J2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP2J2	Pharmacogenomics, SNPs, Pathways
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2j2.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2j2/

Intellectual Property for CYP2J2 gene
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CYP2J2 Gene

cytochrome P450, family 2, subfamily J, polypeptide 2

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CYP2J2 Gene

cytochrome P450, family 2, subfamily J, polypeptide 2

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