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CYP2G1P Gene

pseudogene   GIFtS: 29
GCID: GC19P041396

Cytochrome P450, Family 2, Subfamily G, Polypeptide 1 Pseudogene

(Previous names: cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene)
(Previous symbol: CYP2G1)
  Search for CYP2G1P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily G, Polypeptide 1 Pseudogene1 2
CYP2G11 2
CYP2GP12 3
CYP2G2P2
Cytochrome P450 2G1 Pseudogene3

External Ids:    HGNC: 26331   Entrez Gene: 229522   Ensembl: ENSG000001306127   OMIM: 6011335   UniProtKB: Q6ZSU13   

Export aliases for CYP2G1P gene to outside databases

Previous GC identifer: GC19P046089


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYP2G1P Gene:
CYP2G1P (cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene) is a pseudogene. GO annotations related to this gene include electron carrier activity and heme binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CYP2G1P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CYP2G1P

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2G1P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2G1P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2G1P gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041396:  view genomic region     (about GC identifiers)

Start:
41,396,731 bp from pter      End:
41,406,413 bp from pter
Size:
9,683 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C2G1P_HUMAN, Q6ZSU1 (See protein sequence)
Recommended Name: Putative inactive cytochrome P450 2G1  
Size: 146 amino acids; 16683 Da
Cofactor: Heme group (By similarity)
Caution: Could be the product of a pseudogene. Probable pseudogene which is problably not functional. However,
according to PubMed:11186129, some individuals may have an allele allowing the expression of a functional protein
with an extended N-terminus

Explore the universe of human proteins at neXtProt for CYP2G1P: NX_Q6ZSU1

Explore proteomics data for CYP2G1P at MOPED


See CYP2G1P Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CYP: Cytochrome P450s

3 InterPro protein domains:
 IPR001128 Cyt_P450
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q6ZSU1

ProtoNet protein and cluster: Q6ZSU1

UniProtKB/Swiss-Prot: C2G1P_HUMAN, Q6ZSU1
Similarity: Belongs to the cytochrome P450 family


CYP2G1P for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005506iron ion binding IEA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
GO:0020037heme binding IEA--
     
CYP2G1P for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cyp2g1):
 cellular  craniofacial  hematopoietic system  homeostasis/metabolism  immune system 
 nervous system  respiratory system  taste/olfaction 

CYP2G1P for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Cyp2g1tm1Ding for CYP2G1P

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
golgi apparatus2
endoplasmic reticulum1
mitochondrion1
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CYP2G1P About    
See pathways by source

SuperPathContained pathways About
1acetone degradation I (to methylglyoxal)
nicotine degradation IV0.33
nicotine degradation III0.00
2ethanol degradation II
oxidative ethanol degradation III0.57


3 BioSystems Pathways for CYP2G1P
    nicotine degradation IV
oxidative ethanol degradation III
nicotine degradation III


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYP2G1P
Interactions:

    Search GeneGlobe Interaction Network for CYP2G1P

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CYP2G1P (C2G1P)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000252909(uc002opp.2) ENST00000597833
miRNA
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1 AceView cDNA sequence:

AK127151 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CYP2G1P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGTCCCTTT
CYP2G1P Expression
About this image


CYP2G1P expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Liver (Hepatobiliary System)
         Perivenous Hepatocytes Liver Lobule
CYP2G1P Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CYP2G1P Protein Expression
    Custom PCR Arrays for CYP2G1P
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2G1P

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CYP2G1P gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cyp2g15 cytochrome P450, family 2, subfamily g, polypeptide more   --   7 (15.50 cM) 26808927 


ENSEMBL Gene Tree for CYP2G1P (if available)
TreeFam Gene Tree for CYP2G1P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CYP2G1P gene
Selected SIMAP similar genes for CYP2G1P using alignment to 2 protein entries:     C2G1P_HUMAN (see all proteins) (see all similar genes):
CYP2B7    CYP2B6    CYP2S1    CYP2A7    CYP2C8    CYP2C9
CYP2U1    CYP 2C    DKFZp686I24235    CYP2E1    CYP2D7P1    CYP2F1
CYP2W1    CYP2D6    CYP2R1    CYP1A2    CYP1B1    CYP1A1

CYP2G1P for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CYP2G1P
PGOHUM00000259333


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CYP2G1P (see all 318)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1908313311,2
C--41394768(+) CCTCCC/TGGGTT 1 -- us2k10--------
rs713349531,2
C--41394853(+) GTGTG-/GTGT  
 
/GTGTGT
TGTGT
1 -- us2k11NA 2
rs666895371,2
C--41394880(+) TGTGC-/CA    
   
/TGTG
ATGTA
1 -- us2k10--------
rs1829766171,2
--41395025(+) TTTTGA/GTCTCA 1 -- us2k10--------
rs104177391,2
C,H--41395030(+) ATCTCG/ACTCTG 1 -- us2k113Minor allele frequency- A:0.00NA WA CSA EA 375
rs104183181,2
C,F,A,H--41395036(+) CTCTGA/GTTCTG 1 -- us2k112Minor allele frequency- G:0.41NA WA CSA EA 374
rs1412523551,2
C--41395406(+) GCTGAA/GTCTCT 1 -- us2k10--------
rs129765691,2
C,F--41395410(+) AGTCTC/GTACTC 1 -- us2k13Minor allele frequency- G:0.33NA 6
rs1882615671,2
--41395513(+) CACAGA/GATGCC 1 -- us2k10--------
rs1929396851,2
--41395523(+) CTCAGC/TTCAGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CYP2G1P (41396731 - 41406413 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for CYP2G1P:    About this table    
Variant IDTypeSubtypePubMed ID
esv2718569CNV Deletion23290073
esv2718571CNV Deletion23290073
esv33053CNV Gain17666407
dgv1084e1CNV Complex17122850

Human Gene Mutation Database (HGMD): CYP2G1P
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601133    OMIM disorders: --


CYP2G1P for disorders           About GeneDecksing


Export disorders for CYP2G1P gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CYP2G1P gene integrated from 10 sources:
(articles sorted by number of sources associating them with CYP2G1P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism. (PubMed id 11186129)1, 2, 3, 9 Sheng J.... Ding X. (Pharmacogenetics 2000)
  2. Identification of human genes related to olfactory-specific CYP2G1. (PubMed id 8561797)1, 3, 9 Sheng J. and Ding X. (Biochem. Biophys. Res. Commun. 1996)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Comparative genomics search for losses of long-established genes on the human lineage. (PubMed id 18085818)1 Zhu J....Haussler D. (PLoS Comput. Biol. 2007)
  5. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22952 HGNC: 2633 AceView: CYP2G1 Ensembl:ENSG00000130612 euGenes: HUgn22952
ECgene: CYP2G1P H-InvDB: CYP2G1P

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CYP2G1P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CYP2G1P gene:
Search GeneIP for patents involving CYP2G1P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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