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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP2G1P Gene

pseudogene   GIFtS: 34
GCID: GC19P041396

cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene

(Previous names: cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene...)
(Previous symbol: CYP2G1)
  Search for CYP2G1P
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Biological research products
for CYP2G1P    

Aliases
for CYP2G1P gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome P450, Family 2, Subfamily G, Polypeptide 1 Pseudogene1 2
CYP2GP11 2 3
CYP2G11 2
CYP2G2P2
Cytochrome P450 2G1 Pseudogene3

External Ids:    HGNC: 26331   Entrez Gene: 229522   Ensembl: ENSG000001306127   OMIM: 6011335   UniProtKB: Q6ZSU13   
ORGUL members:         
NONCODE:n383512    

Export aliases for CYP2G1P gene to outside databases

Previous GC identifer: GC19P046089


Summaries
for CYP2G1P gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CYP2G1P gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CYP2G1P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CYP2G1P

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2G1P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2G1P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2G1P gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041396:  view genomic region     (about GC identifiers)

Start:
 41,396,731 bp from pter      End:
 41,406,413 bp from pter
Size:
 9,683 bases      Orientation:
 plus strand

Proteins
for CYP2G1P gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: C2G1P_HUMAN, Q6ZSU1 (See protein sequence)
Recommended Name: Putative inactive cytochrome P450 2G1  
Size: 146 amino acids; 16683 Da
Cofactor: Heme group (By similarity)
Caution: Could be the product of a pseudogene. Probable pseudogene which is problably not functional. However,
according to PubMed:11186129, some individuals may have an allele allowing the expression of a functional protein with
an extended N-terminus

Explore the universe of human proteins at neXtProt for CYP2G1P: NX_Q6ZSU1

CYP2G1P Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000252909  

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Protein Domains /
Families
for CYP2G1P gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
CYP2G1P for domains           About GeneDecksing

3 InterPro domains/families:
 IPR001128 Cyt_P450
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q6ZSU1

ProtoNet protein and cluster: Q6ZSU1

UniProtKB/Swiss-Prot: C2G1P_HUMAN, Q6ZSU1
Similarity: Belongs to the cytochrome P450 family


Function
for CYP2G1P gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
Products:   
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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005506iron ion binding IEA--
GO:0009055electron carrier activity IEA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ----
GO:0020037heme binding IEA--


CYP2G1P for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Cyp2g1tm1Ding for CYP2G1P
     8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cyp2g1):
 cellular  craniofacial  hematopoietic system  homeostasis/metabolism  immune system 
 nervous system  respiratory system  taste/olfaction 

CYP2G1P for phenotypes           About GeneDecksing


Pathways & Interactions
for CYP2G1P gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1nicotine degradation III
nicotine degradation III1.00
nicotine degradation IV0.62
2ethanol degradation II
oxidative ethanol degradation III0.57


3 BioSystems Pathways for CYP2G1P 
    nicotine degradation III
nicotine degradation IV
oxidative ethanol degradation III


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2G1P

Drugs & Compounds
for CYP2G1P gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP2G1P
Search CenterWatch for drugs/clinical trials and news about CYP2G1P 

Transcripts
for CYP2G1P gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for CYP2G1P:

Cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene
Hs.738699  [show with all ESTs]
Unigene Representative Sequence: AK127151
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000252909(uc002opp.2)

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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Additional cDNA sequence: 

AK127151.1 NR_040249.1 

2 DOTS entries:

DT.101968489  DT.102836901 

1 AceView cDNA sequence:

AK127151 

GeneLoc Exon Structure


Expression
for CYP2G1P gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2G1P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTCCCTTT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

CYP2G1P expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
LiverLiver LobulePerivenous HepatocytesLiver
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See CYP2G1P Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.738699
    SABiosciences Custom PCR Arrays for CYP2G1P
Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2G1P

Orthologs
for CYP2G1P gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for CYP2G1P gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Cyp2g15 cytochrome P450, family 2, subfamily g, polypeptide more   --   7 (15.50 cM) 26808927 


ENSEMBL Gene Tree for CYP2G1P (if available)
TreeFam Gene Tree for CYP2G1P (if available) 

Paralogs
for CYP2G1P gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CYP2G1P gene
CYP1B12  CYP1A22  CYP17A12  CYP1A12  ENSG000001982512  CYP21A22  
18/26 SIMAP similar genes for CYP2G1P using alignment to 2 protein entries:     C2G1P_HUMAN (see all proteins) (see all similar genes):
CYP2B7    CYP2B6    CYP2A7    CYP2C8    CYP2S1    CYP2U1
CYP2C9    CYP 2C    DKFZp686I24235    CYP2E1    CYP2D7P1    CYP2F1
CYP2W1    CYP2D6    CYP2R1    CYP2J2    CYP1A2    CYP1B1

CYP2G1P for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CYP2G1P
PGOHUM00000259333


Genomic Variants
for CYP2G1P gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/280 NCBI SNPs in CYP2G1P are shown (see all 280)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 19 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1908313311,2
--41394768(+) CCTCCC/TGGGTT 1 -- us2k10--------
rs1460123341,2
--41394844(+) CTAAT-/TGTG  
        TGTGT 		1 -- us2k10--------
rs1829766171,2
--41395025(+) TTTTGA/GTCTCA 1 -- us2k10--------
rs104177391,2
C,H,--41395030(+) ATCTCG/ACTCTG 1 -- us2k113Minor allele frequency- A:0.00NA WA CSA EA 375
rs104183181,2
C,F,A,H,--41395036(+) CTCTGA/GTTCTG 1 -- us2k112Minor allele frequency- G:0.41NA WA CSA EA 374
rs1412523551,2
--41395406(+) GCTGAA/GTCTCT 1 -- us2k10--------
rs129765691,2
C,F,--41395410(+) AGTCTC/GTACTC 1 -- us2k13Minor allele frequency- G:0.33NA 6
rs1882615671,2
--41395513(+) CACAGA/GATGCC 1 -- us2k10--------
rs1929396851,2
--41395523(+) CTCAGC/TTCAGC 1 -- us2k10--------
rs1395350691,2
--41395540(+) AACCCC/GATTCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CYP2G1P (41396731 - 41406413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CYP2G1P: --
Human Gene Mutation Database (HGMD): CYP2G1P

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for CYP2G1P gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
CYP2G1P for disorders           About MalaCards

CYP2G1P for disorders           About GeneDecksing

OMIM gene information: 601133    OMIM disorders: --


Export disorders for CYP2G1P gene to outside databases

Publications
for CYP2G1P gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CYP2G1P gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYP2G1P)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of human CYP2G genes: widespread los s-of-function mutations and genetic polymorphism. (PubMed id 11186129)1, 2, 3, 9 Sheng J....Ding X. (2000)
  2. Identification of human genes related to olfactory-specific CYP2G1. (PubMed id 8561797)1, 3, 9 Sheng J. and Ding X. (1996)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Comparative genomics search for losses of long-established genes on the human lineage. (PubMed id 18085818)1 Zhu J....Haussler D. (2007)
  5. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)

External Searches for CYP2G1P gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing CYP2G1P gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 22952 HGNC: 2633 AceView: CYP2G1 Ensembl:ENSG00000130612 euGenes: HUgn22952
ECgene: CYP2G1P H-InvDB: CYP2G1P

Other Databases showing CYP2G1P gene

(According to HUGE)
About This Section
   --

Specialized Databases showing CYP2G1P gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CYP2G1P Pharmacogenomics, SNPs, Pathways

Intellectual Property
for CYP2G1P gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CYP2G1P gene:
Search GeneIP for patents involving CYP2G1P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for CYP2G1P gene

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About This Section

 
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