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Aliases for CYP2F1 Gene

Aliases for CYP2F1 Gene

  • Cytochrome P450 Family 2 Subfamily F Member 1 2 3 5
  • Cytochrome P450, Family 2, Subfamily F, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily IIF, Polypeptide 1 2 3
  • EC 4 58
  • CYPIIF1 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 2F1 3
  • CYP2F 3
  • C2F1 3

External Ids for CYP2F1 Gene

Previous HGNC Symbols for CYP2F1 Gene

  • CYP2F

Previous GeneCards Identifiers for CYP2F1 Gene

  • GC19P042259
  • GC19P042012
  • GC19P046109
  • GC19P046125
  • GC19P046129
  • GC19P046312
  • GC19P041620
  • GC19P038052

Summaries for CYP2F1 Gene

Entrez Gene Summary for CYP2F1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2F1 Gene

CYP2F1 (Cytochrome P450 Family 2 Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A6.

UniProtKB/Swiss-Prot for CYP2F1 Gene

  • May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.

Gene Wiki entry for CYP2F1 Gene

Additional gene information for CYP2F1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2F1 Gene

Genomics for CYP2F1 Gene

Regulatory Elements for CYP2F1 Gene

Enhancers for CYP2F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H041172 1.4 Ensembl ENCODE dbSUPER 11.4 +60.5 60455 5.5 ELF3 KLF17 SIN3A SLC30A9 SCRT2 FOS CREM THAP11 SP5 USF2 CYP2S1 AXL CYP2F1 NUMBL DMAC2 PCAT19 RPL36P16 GC19P041185
GH19H040639 1 Ensembl ENCODE 9.6 -473.3 -473256 3 KLF1 HINFP ETV1 ZMYM3 ZNF121 CC2D1A ZFHX2 GLIS2 ZNF366 NCOR1 NUMBL SHKBP1 RNU6-195P SNRPA C19orf54 SERTAD3 SERTAD1 ENSG00000206925 PLD3 C19orf47
GH19H040962 0.8 ENCODE 11.6 -151.5 -151522 0.2 FOXA2 FEZF1 ZEB1 RARA RCOR1 CEBPB ZNF488 ZNF843 ZFP69B PRDM6 CYP2F1 ENSG00000269353 CYP2B6
GH19H040999 0.8 ENCODE 11.1 -113.6 -113617 1.7 SOX13 CTCF FOXA2 PKNOX1 NFIB CEBPG ZSCAN9 RAD21 ZNF316 GATA3 CYP2G1P CYP2A7P1 CYP2F1 PLEKHA3P1 CYP2B6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP2F1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CYP2F1 Gene

Genomic Locations for CYP2F1 Gene
14,090 bases
Plus strand

Genomic View for CYP2F1 Gene

Genes around CYP2F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2F1 Gene

Proteins for CYP2F1 Gene

  • Protein details for CYP2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 2F1
    Protein Accession:
    Secondary Accessions:
    • A7KAU6
    • A7KAU7
    • A7KAU8
    • A7KAU9
    • A7KAV0
    • Q32MN5
    • Q8WWJ2

    Protein attributes for CYP2F1 Gene

    491 amino acids
    Molecular mass:
    55501 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP2F1 Gene


neXtProt entry for CYP2F1 Gene

Selected DME Specific Peptides for CYP2F1 Gene


Post-translational modifications for CYP2F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CYP2F1 Gene

Gene Families for CYP2F1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CYP2F1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2F1: view

Function for CYP2F1 Gene

Molecular function for CYP2F1 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIF,member 1,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,component of a CYP2@ within 240kb,?order
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.018 mM for 3-methylindole {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=51.2 pmol/min/mg enzyme toward ethoxy-coumarin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=24.3 pmol/min/mg enzyme toward propoxy-coumarin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=22 pmol/min/mg enzyme toward pentoxy-resorufin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=2.29 pmol/min/mg enzyme toward benzyloxy-resorufin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816};
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.

Enzyme Numbers (IUBMB) for CYP2F1 Gene

Gene Ontology (GO) - Molecular Function for CYP2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 1974816
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CYP2F1: view
genes like me logo Genes that share phenotypes with CYP2F1: view

Animal Models for CYP2F1 Gene

MGI Knock Outs for CYP2F1:

Animal Model Products

CRISPR Products

miRNA for CYP2F1 Gene

miRTarBase miRNAs that target CYP2F1

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2F1 Gene

Localization for CYP2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2F1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2F1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CYP2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA,IDA 10383923
genes like me logo Genes that share ontologies with CYP2F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2F1 Gene

Pathways & Interactions for CYP2F1 Gene

genes like me logo Genes that share pathways with CYP2F1: view

Gene Ontology (GO) - Biological Process for CYP2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance IEA --
GO:0018931 naphthalene metabolic process IDA 10383923
GO:0018979 trichloroethylene metabolic process IEA --
GO:0019373 epoxygenase P450 pathway IBA --
genes like me logo Genes that share ontologies with CYP2F1: view

No data available for SIGNOR curated interactions for CYP2F1 Gene

Drugs & Compounds for CYP2F1 Gene

(18) Drugs for CYP2F1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 520
Codeine Approved, Illicit Pharma Full agonist, Agonist 83
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1357
Estrone Approved Pharma Agonist Estrogenic hormone 22
Formaldehyde Approved, Vet_approved Pharma 95

(24) Additional Compounds for CYP2F1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2F1: view

Transcripts for CYP2F1 Gene

mRNA/cDNA for CYP2F1 Gene

(10) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2F1 Gene

Cytochrome P450, family 2, subfamily F, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2F1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10

Relevant External Links for CYP2F1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP2F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2F1 Gene

This gene is overexpressed in Minor Salivary Gland (x14.3), Testis (x12.5), Vagina (x9.1), Lung (x7.5), and Esophagus - Mucosa (x6.0).

Protein differential expression in normal tissues from HIPED for CYP2F1 Gene

This gene is overexpressed in Gallbladder (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2F1 Gene

Protein tissue co-expression partners for CYP2F1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP2F1 Gene:


SOURCE GeneReport for Unigene cluster for CYP2F1 Gene:


mRNA Expression by UniProt/SwissProt for CYP2F1 Gene:

Tissue specificity: Expressed in lung. Rarely detected in liver and placenta.

Evidence on tissue expression from TISSUES for CYP2F1 Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with CYP2F1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2F1 Gene

Orthologs for CYP2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2F1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738883 33
  • 94.77 (n)
(Canis familiaris)
Mammalia CYP2F1 34
  • 89 (a)
LOC612477 33
  • 88.46 (n)
(Bos Taurus)
Mammalia CYP2F1 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Cyp2f4 33
  • 82.76 (n)
(Mus musculus)
Mammalia Cyp2f2 33 16 34
  • 82.62 (n)
(Monodelphis domestica)
Mammalia CYP2F1 34
  • 72 (a)
(Anolis carolinensis)
Reptilia CYP2F1 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 35
  • 34 (a)
Cyp304a1 35
  • 30 (a)
Cyp307a1 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea K09A11.4 35
  • 34 (a)
B0213.11 35
  • 33 (a)
C12D5.7 35
  • 32 (a)
F42A9.5 35
  • 32 (a)
T10H4.11 35
  • 32 (a)
Y49C4A.9 35
  • 32 (a)
B0213.12 35
  • 30 (a)
C25E10.2 35
  • 30 (a)
T09H2.1 35
  • 30 (a)
T10H4.10 35
  • 30 (a)
Y5H2B.6 35
  • 30 (a)
B0213.10 35
  • 29 (a)
B0213.14 35
  • 29 (a)
B0213.16 35
  • 29 (a)
C03G6.15 35
  • 29 (a)
F14H3.10 35
  • 29 (a)
K09D9.2 35
  • 29 (a)
B0213.15 35
  • 28 (a)
C49G7.8 35
  • 28 (a)
K07C6.5 35
  • 27 (a)
C03G6.14 35
  • 26 (a)
Species where no ortholog for CYP2F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2F1 Gene

Gene Tree for CYP2F1 (if available)
Gene Tree for CYP2F1 (if available)

Paralogs for CYP2F1 Gene

Variants for CYP2F1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2F1 Gene

Eight non disease-associated alleles are known: CYP2F1*1, CYP2F1*2A, CYP2F1*2B, CYP2F1*3, CYP2F1*4, CYP2F1*5A, CYP2F1*5B and CYP2F1*6. The sequence shown corresponds to allele CYP2F1*1.

Sequence variations from dbSNP and Humsavar for CYP2F1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000247990 -- 41,118,203(+) AGACC(A/C)AATAA intron-variant
rs1000401024 -- 41,123,814(+) CCACC(A/G)CTCCT intron-variant
rs1000407115 -- 41,119,878(+) GGAGG(G/T)TGCAG intron-variant
rs1000629390 -- 41,124,178(+) ACAAG(C/G)CAAGC intron-variant
rs1001138552 -- 41,117,135(+) TGAAT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2F1 Gene

Variant ID Type Subtype PubMed ID
esv28334 CNV loss 19812545
esv3644372 CNV gain 21293372
nsv1065684 CNV gain 25217958
nsv1125310 OTHER inversion 24896259
nsv2492 CNV insertion 18451855

Variation tolerance for CYP2F1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.24; 97.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2F1 Gene

Human Gene Mutation Database (HGMD)
The Human Cytochrome P450 Allele Nomenclature Database
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for CYP2F1 Gene

Relevant External Links for CYP2F1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYP2F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2F1 Gene

Publications for CYP2F1 Gene

  1. Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. (PMID: 17327131) Tournel G … Lo-Guidice JM (Mutation research 2007) 3 4 45 60
  2. CYP2F1 genetic polymorphism: identification of interethnic variations. (PMID: 17943660) Tournel G … Lo-Guidice J- (Xenobiotica; the fate of foreign compounds in biological systems 2007) 3 22 45 60
  3. Identification and cross-species comparisons of CYP2F subfamily genes in mammals. (PMID: 11827709) Chen N … Hoffman SM (Mutation research 2002) 3 4 22 60
  4. The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. (PMID: 1974816) Nhamburo PT … Gonzalez FJ (Biochemistry 1990) 3 4 22 60
  5. [The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]. (PMID: 20198857) Korytina GF … Viktorova TV (Molekuliarnaia biologiia 2010) 3 45 60

Products for CYP2F1 Gene

Sources for CYP2F1 Gene

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