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CYP2F1 Gene

protein-coding   GIFtS: 61

GC19P041620
cytochrome P450, family 2, subfamily F, polypeptide 1
(Previous names: cytochrome P450, subfamily IIF, polypeptide 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP2F)
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Aliases &
Descriptions
for CYP2F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
cytochrome P450, family 2, subfamily F, polypeptide 11 2     xenobiotic monooxygenase2
cytochrome P450, subfamily IIF, polypeptide 11 2     MGC1261212
CYPIIF12 3     cytochrome P450 2F12
CYP2F2     flavoprotein-linked monooxygenase2
C2F12     EC 1.14.14.13
microsomal monooxygenase2     

External Ids:    HGNC: 26321   Entrez Gene: 15722   Ensembl: ENSG000001974467   UniProtKB: P249033   

Search outside databases for aliases for CYP2F1 gene

Previous GC identifers: GC19P042259 GC19P042012 GC19P046109 GC19P046125 GC19P046129 GC19P046312

Summaries
for CYP2F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  User Feedback		 Entrez Gene summary for CYP2F1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an
endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and
ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F
subfamilies on chromosome 19q. (provided by RefSeq)

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate
ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace
dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative
electrophile 3-methylene-indolenine

Gene Wiki entry for CYP2F1

Genomic Views
for CYP2F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CYP2F1 gene upstream (promoter) region "":
Sp1   PPAR-gamma1   PPAR-gamma2   CUTL1   RFX1   HNF-4alpha2   STAT5A   c-Rel   RelA   IRF-7A   

Epigenetics:
"" Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP2F1 ""

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

CYP2F1 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041620:  view genomic region     (about GC identifiers)

Start:
 41,620,353 bp from pter
End:
 41,634,281 bp from pter
Size:
 13,929 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

Proteins
for CYP2F1 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903 (See protein sequence)
Recommended Name: Cytochrome P450 2F1  
Size: 491 amino acids; 55501 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Microsome membrane;
Peripheral membrane protein
Secondary accessions: A7KAU6 A7KAU7 A7KAU8 A7KAU9 A7KAV0 Q8WWJ2

REFSEQ proteins: NP_000765.2  

ENSEMBL proteins: 
ENSP00000333534 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Enzo Life Sciences proteins for CYP2F1
""HuPro® and/or Recombinant Proteins from Abnova for CYP2F1 ""
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Novus Biologicals Protein for CYP2F1  ""
""Browse Sino Biological Recombinant Proteins  ""

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane EXP10383923
GO:0005792 microsome IDA10383923
GO:0016020 membrane IEA--
GO:0019898 extrinsic to membrane ----
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Antibodies for CYP2F1: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for CYP2F1
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (CYP2F1)
""Browse Origene Antibodies ""
""Novus Biologicals Antibody for CYP2F1
""Browse antibodies at Epitomics

Assays for CYP2F1: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Enzo Life Sciences assays for CYP2F1

Protein Domains/
Families
for CYP2F1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR001128 Cyt_P450
 IPR017973 Cyt_P450_C
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I
 IPR020469 Cytochrome_P450_CYP2_fam

Graphical View of Domain Structure for InterPro Entry P24903

ProtoNet protein and cluster: P24903

2 Blocks protein families:
IPB002401 E-class P450 group I signature
IPB008068 CYP2B P450 family signature


UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
Similarity: Belongs to the cytochrome P450 family

Gene Function
for CYP2F1 gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (CYP2F1)
"" Origene 29mer shRNA kits in GFP-retroviral vector: CYP2F1
Origene shRNA RFP: CYP2F1
Origene basic RS shRNA: CYP2F1

""Applied Biosystems Silencer® siRNAs for CYP2F1
""Sigma-Aldrich siRNA Panels and siRNA for CYP2F1
Sigma-Aldrich shRNA for CYP2F1
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2F1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2F1
Origene untagged cDNA clones in CMV expression vector (see all 3): CYP2F1
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate
ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace
dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative
electrophile 3-methylene-indolenine
Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
Biophysicochemical properties: Kinetic parameters: KM=0.018 mM for 3-methylindole; Vmax=51.2 pmol/min/mg enzyme toward
ethoxy-coumarin; Vmax=24.3 pmol/min/mg enzyme toward propoxy-coumarin; Vmax=22 pmol/min/mg enzyme toward
pentoxy-resorufin; Vmax=2.29 pmol/min/mg enzyme toward benzyloxy-resorufin;
Enzyme Number (IUBMB): EC 1.14.14.1 

Genatlas biochemistry entry for CYP2F1:
cytochrome P450,subfamily IIF,member 1,tightly linked to a full size LTR of human endogenous retroviruses
HERV-K,component of a CYP2@ within 240kb,?order

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0004497 monooxygenase activity TAS1974816
GO:0005506 iron ion binding ----
GO:0009055 electron carrier activity IEA--
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA10383923
GO:0019825 oxygen binding EXP10383923
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Pathways & Interactions
for CYP2F1 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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"" CYP2F1 for pathways           About GeneDecksing

3 "" Millipore Pathways for CYP2F1
  ""  Dichloroethylene metabolism
2-Naphthylamine and 2-Nitronaphtalene metabolism
Naphthalene metabolism

5 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  CYP2F1  (Your Favorite Gene powered by Ingenuity)
  ""  Linoleic Acid Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Tryptophan Metabolism
Arachidonic Acid Metabolism
Fatty Acid Metabolism

1 "" Kegg Pathway  (Kegg details for CYP2F1):
  ""  hsa00980 Metabolism of xenobiotics by cytochrome P450

"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2F1

5/50 Interacting proteins for CYP2F1 (ENSP000003335343) via UniProtKB, MINT, and/or STRING (see all 50 ) ""
InteractantInteraction Details
GeneCardExternal ID(s)
ADHFE1ENSP000002765763STRING: ENSP00000276576
AKR1C2ENSP000003701293STRING: ENSP00000370129
AKR1C3ENSP000003699273STRING: ENSP00000369927
ALDH1A3ENSP000003322563STRING: ENSP00000332256
DHDHENSP000002214033STRING: ENSP00000221403
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0009636 response to toxin IEA--
GO:0018931 naphthalene metabolic process IDA10383923
GO:0055114 oxidation reduction IEA--
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Drugs & Compounds
for CYP2F1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" CYP2F1 for compounds           About GeneDecksing

"" Enzo Life Sciences drugs & compounds for CYP2F1
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for CYP2F1
10/15 ""Novoseek chemical compound relationships for CYP2F1 gene (see all 15 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
3-methylindole 18.28 7 17962375 (5), 20187624 (2)
naphthalene 7.06 4 15509722 (2), 17962375 (1), 14724224 (1)
chloralhydrate 5.98 3 15987776 (3)
polystyrene 5.71 5 12202046 (4), 17962375 (1)
trichloroethylene 4.49 3 15987776 (3)
5-phenyl-1-pentyne 3.79 1 12202046 (1)
3-methyleneindolenine 3.62 1 20187624 (1)
1-nitronaphthalene 2.94 1 15509722 (1)
p-ethylphenol 2.61 1 12202046 (1)
1,1-dichloroethylene 2.25 1 17962375 (1)
About this table


Transcripts
for CYP2F1 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (CYP2F1)
""Applied Biosystems Silencer® siRNAs:  NM_000774  
"" Origene 29mer shRNA kits in GFP-retroviral vector: CYP2F1
Origene shRNA RFP: CYP2F1
Origene basic RS shRNA: CYP2F1

""Sigma-Aldrich siRNA Panels and siRNA for CYP2F1
Sigma-Aldrich shRNA for CYP2F1
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate CYP2F1: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_000774  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: CYP2F1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CYP2F1
Origene untagged cDNA clones in CMV expression vector (see all 3): CYP2F1
Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2F1
""SABiosciences RT2 qPCR Primer Assay for CYP2F1: PPH01272A ""

REFSEQ mRNAs for CYP2F1 gene: 

NM_000774.3  

Additional cDNA sequence: 

AK296884.1 AK298082.1 AK316498.1 BC109056.1 BC109057.1 J02906.1 

4 DOTS entries:

DT.102624  DT.121503462  DT.99996904  DT.95094345 

7 AceView cDNA sequences:

NM_000774 CB306453 J02906 BI063387 BE829867 BM968957 CD688412 

"" highest scoring ESTs for CYP2F1:

J02906 BM980187 CA312356 CB306453 CB851670 NM_000774 BC109056 BC109057 BM968957 CD688412 

Unigene Cluster for CYP2F1:

Cytochrome P450, family 2, subfamily F, polypeptide 1
Hs.558318  [show with all ESTs]
Unigene Representative Sequence: AK298082


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2F1

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:                                                                        
SP2:                                                                        

About this scheme

ECgene alternative splicing isoforms for CYP2F1

1 Ensembl transcript including schematic representation:
ENST00000331105  

Expression
for CYP2F1 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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CYP2F1 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for CYP2F1

1""  / 2""  / 3""

3 probe-sets matching CYP2F1 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1517_at2, 3 U95-A 2 0.50 0.72 1.00 1.00 J02906 0.80 0.88 0.84 1
207913_at2, 3 U133-A 2 0.64 0.75 -- -- NM_000774 0.60 1.00 0.82 1
207913_at2 U133Plus2 2 0.64 0.75 -- -- -- -- -- -- --
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Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.558318

Expression variation in blood from EXPOLDB for CYP2F1

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
Tissue specificity: Expressed in lung. Rarely detected in liver and placenta

Primers:"" Origene genome-wide validated SYBR primer pairs: CYP2F1 ""
""SABiosciences RT2 qPCR Primer Assay for CYP2F1: PPH01272A ""

Orthologs
for CYP2F1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CYP2F1 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC6124771   -- similar to cytochrome P450, family 2, subfamily F, more 88.12(n)
88.8(a)		 612477  XM_850208.1  XP_855301.1 
rat
(Rattus norvegicus)		 Cyp2f41   -- cytochrome P450, family 2, subfamily f, polypeptide more 82.76(n)
83.06(a)		 54246  NM_019303.1  NP_062176.1 
mouse
(Mus musculus)		 Cyp2f21, 5 75
 cytochrome P450, family 2, subfamily f, polypeptide more1, 5 82.62(n)1
81.87(a)1		 131071  NM_007817.21  NP_031843.21 
 AK0869075  BC0110895  (see all 11)
fruit fly
(Drosophila melanogaster)		 Cyp18a13 17D1 steroid biosynthesis cytochrome P450 34(a)
(best of 3)		   --
worm
(Caenorhabditis elegans)		 K09A11.43 X(13307102-13309423) cytochrome p450 34(a)
(best of 21)		   --
About this table        Species with no ortholog for CYP2F1

ENSEMBL Gene Tree for CYP2F1

Paralogs
for CYP2F1 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for CYP2F1 gene
CYP2W12  CYP2C82  CYP2G1P2  CYP2R12  CYP2J22  CYP2U12  CYP2E12  CYP2D62  
CYP2D7P12  CYP2A62  CYP2B62  CYP2C192  CYP2S12  CYP2C92  CYP2C182  CYP2A132  

"" CYP2F1 for paralogs           About GeneDecksing


Genomic Variants
for CYP2F1 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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  User Feedback		UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
Polymorphism: Eight non disease-associated alleles are known: CYP2F1*1, CYP2F1*2A, CYP2F1*2B, CYP2F1*3, CYP2F1*4,
CYP2F1*5A, CYP2F1*5B and CYP2F1*6. The sequence shown corresponds to allele CYP2F1*1


10/171 NCBI SNPs in CYP2F1 are shown (see all 171 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 43)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs17091181,2
C,F,A,H38066403(-) acctcG/Acctgg 1 -- ng31""4Minor allele frequency- A:0.30NA 10""
--
rs16456731,2
C,O,A,H38066208(+) GTGAGA/GATGAG 1 -- ng31""0--------
--
rs39201,2
C,F,A,H41634151(+) TCTGTA/GCCCCG 1 -- ut31 ese3""4Minor allele frequency- G:0.23MN NA 192""
""
rs17091151,2
C,F,A,H38051475(-) AGCCAA/GGCTGA 1 -- ng51""6Minor allele frequency- G:0.10NS EA WA NA 464""
--
rs48020921,2
C,F,A,H38066359(-) GCCTCT/ACTGGC 1 -- ng31""3Minor allele frequency- A:0.50NA 8""
--
rs124614121,2
C,F,H41634036(+) CCATGC/TGGGTT 1 -- ut31 ese3""1Minor allele frequency- T:0.50NA 4""
--
rs124614281,2
C,F,H41634155(+) TGCCCC/TGTCTG 1 -- ut31 ese3""1Minor allele frequency- T:0.50NA 4""
--
rs26048651,2
C,A,H38066296(+) GCTAGA/GGTGGG 1 -- ng31""0--------
""
rs17091141,2
C,F,A38051651(-) tccttT/Cggtgt 1 -- ng51 trp3""8Minor allele frequency- C:0.08NS EA NA WA 624""
--
rs124614141,2
C,F,H41634073(+) CTGCCC/TTCATC 1 -- ut31""1Minor allele frequency- T:0.50NA 4""
About this table

HapMap Linkage Disequilibrium images for CYP2F1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
Database of Genomic Variants (DGV): 1 variation for CYP2F1
     1 CNV: 67548

Disorders & Mutations
for CYP2F1 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 124070

9 ""Novoseek disease relationships for CYP2F1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma; nasopharyngeal 3.66 3 16883522 (3)
lung tumor 2.83 2 12202046 (2)
copd 2.36 3 20198857 (3)
disease obstructive lung 1.69 1 20198857 (1)
lung cancer 1.54 3 17327131 (2), 17943660 (1)
arthritis 1.53 2 14962958 (2)
lymph node metastasis 0.81 1 15897573 (1)
primary tumor 0.77 1 15897573 (1)
ovarian cancer 0.50 1 16243809 (1)
About this table

Locus Specific Mutation Databases: CYP2F1
Human Gene Mutation Database: CYP2F1
Human Genome Epidemiology Navigator: CYP2F1 (5 documents)

Medical News
for CYP2F1 gene

(Possibly Related Articles in Doctor's Guide)
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Publications
for CYP2F1 gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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  User Feedback		10/40 PubMed articles for CYP2F1 gene (see all 40 ):

Search for CYP2F1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing CYP2F1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1572 HGNC: 2632 AceView: CYP2F1 Ensembl:ENSG00000197446 euGenes: HUgn1572
ECgene: CYP2F1 Kegg: 1572 H-InvDB: CYP2F1

Other Databases showing CYP2F1 gene

(According to HUGE)
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Specialized Databases showing CYP2F1 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2f1.htm

Intellectual Property
for CYP2F1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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  User Feedback		Patent Information for CYP2F1 gene: ""
Search GeneIP for patents involving CYP2F1

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Services
for CYP2F1 gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CYP2F1:
"" TaqMan ® Gene Expression Assays
"" TaqMan ® Genotyping Assays
 "" Free SNP selection tool

""
"" Millipore Custom Antibody & Bulk Services
"" Millipore Preclinical / Clinical Development Services
"" Millipore Immunoassay Services
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""
"" Predesigned and custom siRNAs for CYP2F1"" Antibodies for CYP2F1
"" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
"" Lentivirus-delivered shRNAs for CYP2F1"" Browse small molecules at Sigma-Aldrich
"" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
"" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


 ""  ""
"" Antibodies  "" Primer Pairs  
"" Cell Culture Products  "" ELISAs  
"" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
"" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
"" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
"" Recombinant & Natural Proteins  

"" Recombinant Proteins (CYP2F1)
"" Antibodies (CYP2F1)
"" Chimera RNAi (CYP2F1)
"" Custom Service for Mouse Mab
"" Custom Service for Rabbit Pab from Full-length Protein


""""""""
"" Search for Antibodies & Assays

"" Tagged/untagged cDNA clones
"" Validated SYBR primer pairs
"" Purified proteins from HEK293T cells
"" Western blot validated antibodies
"" shRNA in GFP-retroviral vector
"" Custom immunoassay development
"" Search Tocris compounds for CYP2F1
"" Regulatory tfbs in CYP2F1 upstream (promoter) region
"" Search Chromatin IP Primers for CYP2F1
"" Search DNA Methylation qPCR Primer Assays for CYP2F1
"" RT2 qPCR Primer Assay for CYP2F1
"" Search GNC Networks for CYP2F1
"" Search for microRNAs that regulate CYP2F1
""""""""
"" Assays/Drugs/Proteins for CYP2F1
"" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
"" Novus Tissue Slides
"" Antibodies for CYP2F1
"" Proteins for CYP2F1
"" Browse antibodies at Epitomics
"" Browse Sino Biological Proteins and Antibodies
"" Browse Sino Biological cDNA Clones
"" Antibodies/Proteins Production Services
"" Rabbit Monoclonal Antibody Platform
"" Bulk Purchasing
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